Adelbert Bacher

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TOP 3
Lehmann Martin; Degen Simone; Hohmann Hans-Peter; Wyss Markus; Bacher Adelbert; Schramek Nicholas
Biosynthesis of riboflavin. Screening for an improved GTP cyclohydrolase II mutant.
Talukdar Arindam; Breen Meghan; Bacher Adelbert; Illarionov Boris; Fischer Markus; Georg Gunda; Ye Qi-Zhuang; Cushman Mark
Discovery and development of a small molecule library with lumazine synthase inhibitory activity.
Zhao Yujie; Bacher Adelbert; Illarionov Boris; Fischer Markus; Georg Gunda; Ye Qi-Zhuang; Fanwick Phillip E; Franzblau Scott G; Wan Baojie; Cushman Mark
Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis.

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All Publications

2009: Lehmann Martin; Degen Simone; Hohmann Hans-Peter; Wyss Markus; Bacher Adelbert; Schramek Nicholas
Biosynthesis of riboflavin. Screening for an improved GTP cyclohydrolase II mutant.
The FEBS journal 2009;276(15):4119-29.
2009: Talukdar Arindam; Breen Meghan; Bacher Adelbert; Illarionov Boris; Fischer Markus; Georg Gunda; Ye Qi-Zhuang; Cushman Mark
Discovery and development of a small molecule library with lumazine synthase inhibitory activity.
The Journal of organic chemistry 2009;74(15):5123-34.
2009: Zhao Yujie; Bacher Adelbert; Illarionov Boris; Fischer Markus; Georg Gunda; Ye Qi-Zhuang; Fanwick Phillip E; Franzblau Scott G; Wan Baojie; Cushman Mark
Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis.
The Journal of organic chemistry 2009;74(15):5297-303.
2009: Eisenreich Wolfgang; Fischer Markus; Römisch-Margl Werner; Joshi Monika; Richter Gerald; Bacher Adelbert; Weber Stefan
Tryptophan 13C nuclear-spin polarization generated by intraprotein electron transfer in a LOV2 domain of the blue-light receptor phototropin.
Biochemical Society transactions 2009;37(Pt 2):382-6.
2009: Gräwert Tobias; Rohdich Felix; Span Ingrid; Bacher Adelbert; Eisenreich Wolfgang; Eppinger Jörg; Groll Michael
Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction.
Angewandte Chemie (International ed. in English) 2009;48(31):5756-9.
2008: Yu Tsyr-Yan; O'Connor Robert D; Sivertsen Astrid C; Chiauzzi Colby; Poliks Barbara; Fischer Markus; Bacher Adelbert; Haase Ilka; Cushman Mark; Schaefer Jacob
(15)N{(31)P} REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase.
Biochemistry 2008;47(52):13942-51.
2008: Eisenreich Wolfgang; Joshi Monika; Weber Stefan; Bacher Adelbert; Fischer Markus
Natural abundance solution 13C NMR studies of a phototropin with photoinduced polarization.
Journal of the American Chemical Society 2008;130(41):13544-5.
2008: Henbest Kevin B; Maeda Kiminori; Hore P J; Joshi Monika; Bacher Adelbert; Bittl Robert; Weber Stefan; Timmel Christiane R; Schleicher Erik
Magnetic-field effect on the photoactivation reaction of Escherichia coli DNA photolyase.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14395-9.
2008: Römisch-Margl Werner; Eisenreich Wolfgang; Haase Ilka; Bacher Adelbert; Fischer Markus
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthases of fungi and archaea.
The FEBS journal 2008;275(17):4403-14.
2008: Chatwell Lorenz; Illarionova Victoria; Illarionov Boris; Eisenreich Wolfgang; Huber Robert; Skerra Arne; Bacher Adelbert; Fischer Markus
Structure of lumazine protein, an optical transponder of luminescent bacteria.
Journal of molecular biology 2008;382(1):44-55.
2008: Hirsch Anna K H; Alphey Magnus S; Lauw Susan; Seet Michael; Barandun Luzi; Eisenreich Wolfgang; Rohdich Felix; Hunter William N; Bacher Adelbert; Diederich François
Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis.
Organic & biomolecular chemistry 2008;6(15):2719-30.
2008: Eylert Eva; Schär Jennifer; Mertins Sonja; Stoll Regina; Bacher Adelbert; Goebel Werner; Eisenreich Wolfgang
Carbon metabolism of Listeria monocytogenes growing inside macrophages.
Molecular microbiology 2008;69(4):1008-17.
2008: Lauw Susan; Illarionova Victoria; Bacher Adelbert; Rohdich Felix; Eisenreich Wolfgang
Biosynthesis of isoprenoids: studies on the mechanism of 2C-methyl-D-erythritol-4-phosphate synthase.
The FEBS journal 2008;275(16):4060-73.
2008: Rodríguez-Fernández Lidia; López-Jaramillo F Javier; Bacher Adelbert; Fischer Markus; Weinkauf Sevil
Improvement of the quality of lumazine synthase crystals by protein engineering.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 7):625-8.
2008: Sgraja Tanja; Alphey Magnus S; Ghilagaber Stephanos; Marquez Rudi; Robertson Murray N; Hemmings Jennifer L; Lauw Susan; Rohdich Felix; Bacher Adelbert; Eisenreich Wolfgang; Illarionova Victoria; Hunter William N
Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery.
The FEBS journal 2008;275(11):2779-94.
2008: Fischer Markus; Bacher Adelbert
Biosynthesis of vitamin B2: Structure and mechanism of riboflavin synthase.
Archives of biochemistry and biophysics 2008;474(2):252-65.
2008: Zhang Yanlei; Illarionov Boris; Morgunova Ekaterina; Jin Guangyi; Bacher Adelbert; Fischer Markus; Ladenstein Rudolf; Cushman Mark
A new series of N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: design, synthesis, biochemical evaluation, crystallography, and mechanistic implications.
The Journal of organic chemistry 2008;73(7):2715-24.
2008: Crane Christine M; Hirsch Anna K H; Alphey Magnus S; Sgraja Tanja; Lauw Susan; Illarionova Victoria; Rohdich Felix; Eisenreich Wolfgang; Hunter William N; Bacher Adelbert; Diederich François
Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis.
ChemMedChem 2008;3(1):91-101.
2007: Illarionov Boris; Eisenreich Wolfgang; Wirth Martina; Yong Lee Chan; Eun Woo Young; Bacher Adelbert; Fischer Markus
Lumazine proteins from photobacteria: localization of the single ligand binding site to the N-terminal domain.
Biological chemistry 2007;388(12):1313-23.
2007: Eisenreich Wolfgang; Bacher Adelbert
Advances of high-resolution NMR techniques in the structural and metabolic analysis of plant biochemistry.
Phytochemistry 2007;68(22-24):2799-815.
2007: Eisenreich Wolfgang; Joshi Monika; Illarionov Boris; Richter Gerald; Römisch-Margl Werner; Müller Franz; Bacher Adelbert; Fischer Markus
13C Isotopologue editing of FMN bound to phototropin domains.
The FEBS journal 2007;274(22):5876-90.
2007: Ostrozhenkova Elena; Eylert Eva; Schramek Nicholas; Golan-Goldhirsh Avi; Bacher Adelbert; Eisenreich Wolfgang
Biosynthesis of the chromogen hermidin from Mercurialis annua L.
Phytochemistry 2007;68(22-24):2816-24.
2007: Hain Torsten; Chatterjee Som S; Ghai Rohit; Kuenne Carsten Tobias; Billion André; Steinweg Christiane; Domann Eugen; Kärst Uwe; Jänsch Lothar; Wehland Jürgen; Eisenreich Wolfgang; Bacher Adelbert; Joseph Biju; Schär Jennifer; Kreft Jürgen; Klumpp Jochen; Loessner Martin J; Dorscht Julia; Neuhaus Klaus; Fuchs Thilo M; Scherer Siegfried; Doumith Michel; Jacquet Christine; Martin Paul; Cossart Pascale; Rusniock Christophe; Glaser Philippe; Buchrieser Carmen; Goebel Werner; Chakraborty Trinad
Pathogenomics of Listeria spp.
International journal of medical microbiology : IJMM 2007;297(7-8):541-57.
2007: Klinke Sebastián; Zylberman Vanesa; Bonomi Hernán R; Haase Ilka; Guimarães Beatriz G; Braden Bradford C; Bacher Adelbert; Fischer Markus; Goldbaum Fernando A
Structural and kinetic properties of lumazine synthase isoenzymes in the order Rhizobiales.
Journal of molecular biology 2007;373(3):664-80.
2007: Zhang Yanlei; Jin Guangyi; Illarionov Boris; Bacher Adelbert; Fischer Markus; Cushman Mark
A new series of 3-alkyl phosphate derivatives of 4,5,6,7-tetrahydro-1-D-ribityl-1H-pyrazolo[3,4-d]pyrimidinedione as inhibitors of lumazine synthase: design, synthesis, and evaluation.
The Journal of organic chemistry 2007;72(19):7176-84.
2007: Talukdar Arindam; Illarionov Boris; Bacher Adelbert; Fischer Markus; Cushman Mark
Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase.
The Journal of organic chemistry 2007;72(19):7167-75.
2007: Römisch-Margl Werner; Schramek Nicholas; Radykewicz Tanja; Ettenhuber Christian; Eylert Eva; Huber Claudia; Römisch-Margl Lilla; Schwarz Christine; Dobner Maria; Demmel Norbert; Winzenhörlein Bernhard; Bacher Adelbert; Eisenreich Wolfgang
13CO2 as a universal metabolic tracer in isotopologue perturbation experiments.
Phytochemistry 2007;68(16-18):2273-89.
2007: Morgunova Ekaterina; Saller Sabine; Haase Ilka; Cushman Mark; Bacher Adelbert; Fischer Markus; Ladenstein Rudolf
Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design.
The Journal of biological chemistry 2007;282(23):17231-41.
2007: Kaiser Johannes; Illarionov Boris; Rohdich Felix; Eisenreich Wolfgang; Saller Sabine; den Brulle Jan Van; Cushman Mark; Bacher Adelbert; Fischer Markus
A high-throughput screening platform for inhibitors of the riboflavin biosynthesis pathway.
Analytical biochemistry 2007;365(1):52-61.
2007: Hirsch Anna K H; Lauw Susan; Gersbach Philipp; Schweizer W Bernd; Rohdich Felix; Eisenreich Wolfgang; Bacher Adelbert; Diederich François
Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy.
ChemMedChem 2007;2(6):806-10.
2007: Zhang Yanlei; Illarionov Boris; Bacher Adelbert; Fischer Markus; Georg Gunda I; Ye Qi-Zhuang; Vander Velde David; Fanwick Phillip E; Song Yunlong; Cushman Mark
A novel lumazine synthase inhibitor derived from oxidation of 1,3,6,8-tetrahydroxy-2,7-naphthyridine to a tetraazaperylenehexaone derivative.
The Journal of organic chemistry 2007;72(8):2769-76.
2007: Kaiser J; Yassin M; Prakash S; Safi N; Agami M; Lauw S; Ostrozhenkova E; Bacher A; Rohdich F; Eisenreich W; Safi J; Golan-Goldhirsh A
Anti-malarial drug targets: screening for inhibitors of 2C-methyl-D-erythritol 4-phosphate synthase (IspC protein) in Mediterranean plants.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2007;14(4):242-9.
2007: Lee Chan Yong; Illarionov Boris; Woo Young-Eun; Kemter Kristina; Kim Ryu-Ryun; Eberhardt Sabine; Cushman Mark; Eisenreich Wolfgang; Fischer Markus; Bacher Adelbert
Ligand binding properties of the N-terminal domain of riboflavin synthase from Escherichia coli.
Journal of biochemistry and molecular biology 2007;40(2):239-46.
2007: Amslinger Sabine; Hecht Stefan; Rohdich Felix; Eisenreich Wolfgang; Adam Petra; Bacher Adelbert; Bauer Stefan
Stimulation of Vgamma9/Vdelta2 T-lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate.
Immunobiology 2007;212(1):47-55.
2006: Illarionova Victoria; Kaiser Johannes; Ostrozhenkova Elena; Bacher Adelbert; Fischer Markus; Eisenreich Wolfgang; Rohdich Felix
Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods.
The Journal of organic chemistry 2006;71(23):8824-34.
2006: Morgunova Ekaterina; Illarionov Boris; Sambaiah Thota; Haase Ilka; Bacher Adelbert; Cushman Mark; Fischer Markus; Ladenstein Rudolf
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis.
The FEBS journal 2006;273(20):4790-804.
2006: Rohdich Felix; Lauw Susan; Kaiser Johannes; Feicht Richard; Köhler Peter; Bacher Adelbert; Eisenreich Wolfgang
Isoprenoid biosynthesis in plants - 2C-methyl-D-erythritol-4-phosphate synthase (IspC protein) of Arabidopsis thaliana.
The FEBS journal 2006;273(19):4446-58.
2006: Zhang Xiaofeng; Konarev Petr V; Petoukhov Maxim V; Svergun Dmitri I; Xing Li; Cheng R Holland; Haase Ilka; Fischer Markus; Bacher Adelbert; Ladenstein Rudolf; Meining Winfried
Multiple assembly states of lumazine synthase: a model relating catalytic function and molecular assembly.
Journal of molecular biology 2006;362(4):753-70.
2006: Zylberman Vanesa; Klinke Sebastián; Haase Ilka; Bacher Adelbert; Fischer Markus; Goldbaum Fernando Alberto
Evolution of vitamin B2 biosynthesis: 6,7-dimethyl-8-ribityllumazine synthases of Brucella.
Journal of bacteriology 2006;188(17):6135-42.
2006: Spielbauer Gertraud; Margl Lilla; Hannah L Curtis; Römisch Werner; Ettenhuber Christian; Bacher Adelbert; Gierl Alfons; Eisenreich Wolfgang; Genschel Ulrich
Robustness of central carbohydrate metabolism in developing maize kernels.
Phytochemistry 2006;67(14):1460-75.
2006: Chatwell Lorenz; Krojer Tobias; Fidler Alexander; Römisch Werner; Eisenreich Wolfgang; Bacher Adelbert; Huber Robert; Fischer Markus
Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii.
Journal of molecular biology 2006;359(5):1334-51.
2006: Gabrielsen Mads; Kaiser Johannes; Rohdich Felix; Eisenreich Wolfgang; Laupitz Ralf; Bacher Adelbert; Bond Charles S; Hunter William N
The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate.
The FEBS journal 2006;273(5):1065-73.
2006: Eisenreich Wolfgang; Slaghuis Jörg; Laupitz Ralf; Bussemer Johanna; Stritzker Jochen; Schwarz Christine; Schwarz Roland; Dandekar Thomas; Goebel Werner; Bacher Adelbert
13C isotopologue perturbation studies of Listeria monocytogenes carbon metabolism and its modulation by the virulence regulator PrfA.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2040-5.
2006: Crane Christine M; Kaiser Johannes; Ramsden Nicola L; Lauw Susan; Rohdich Felix; Eisenreich Wolfgang; Hunter William N; Bacher Adelbert; Diederich François
Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy.
Angewandte Chemie (International ed. in English) 2006;45(7):1069-74.
2006: Ramsperger Arne; Augustin Martin; Schott Ann-Kathrin; Gerhardt Stefan; Krojer Tobias; Eisenreich Wolfgang; Illarionov Boris; Cushman Mark; Bacher Adelbert; Huber Robert; Fischer Markus
Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: stereochemical implications.
The Journal of biological chemistry 2006;281(2):1224-32.
2005: Richter Gerald; Weber Stefan; Römisch Werner; Bacher Adelbert; Fischer Markus; Eisenreich Wolfgang
Photochemically induced dynamic nuclear polarization in a C450A mutant of the LOV2 domain of the Avena sativa blue-light receptor phototropin.
Journal of the American Chemical Society 2005;127(49):17245-52.
2005: Illarionov Boris; Lee Chan Yong; Bacher Adelbert; Fischer Markus; Eisenreich Wolfgang
Random isotopolog libraries for protein perturbation studies. 13C NMR studies on lumazine protein of Photobacterium leiognathi.
The Journal of organic chemistry 2005;70(24):9947-54.
2005: Ettenhuber Christian; Spielbauer Gertraud; Margl Lilla; Hannah L Curtis; Gierl Alfons; Bacher Adelbert; Genschel Ulrich; Eisenreich Wolfgang
Changes in flux pattern of the central carbohydrate metabolism during kernel development in maize.
Phytochemistry 2005;66(22):2632-42.
2005: Zepeck Ferdinand; Gräwert Tobias; Kaiser Johannes; Schramek Nicholas; Eisenreich Wolfgang; Bacher Adelbert; Rohdich Felix
Biosynthesis of isoprenoids. purification and properties of IspG protein from Escherichia coli.
The Journal of organic chemistry 2005;70(23):9168-74.
2005: Cushman Mark; Jin Guangyi; Sambaiah Thota; Illarionov Boris; Fischer Markus; Ladenstein Rudolf; Bacher Adelbert
Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase.
The Journal of organic chemistry 2005;70(20):8162-70.
2005: Kay Christopher W M; Bittl Robert; Bacher Adelbert; Richter Gerald; Weber Stefan
Unambiguous determination of the g-matrix orientation in a neutral flavin radical by pulsed electron-nuclear double resonance at 94 GHz.
Journal of the American Chemical Society 2005;127(31):10780-1.
2005: Rohdich F; Bacher A; Eisenreich W
Isoprenoid biosynthetic pathways as anti-infective drug targets.
Biochemical Society transactions 2005;33(Pt 4):785-91.
2005: Fischer M; Römisch W; Illarionov B; Eisenreich W; Bacher A
Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.
Biochemical Society transactions 2005;33(Pt 4):780-4.
2005: Illarionov Boris; Eisenreich Wolfgang; Schramek Nicholas; Bacher Adelbert; Fischer Markus
Biosynthesis of vitamin B2: diastereomeric reaction intermediates of archaeal and non-archaeal riboflavin synthases.
The Journal of biological chemistry 2005;280(31):28541-6.
2005: Fischer Markus; Bacher Adelbert
Biosynthesis of flavocoenzymes.
Natural product reports 2005;22(3):324-50.
2005: Gescher Johannes; Eisenreich Wolfgang; Wörth Jürgen; Bacher Adelbert; Fuchs Georg
Aerobic benzoyl-CoA catabolic pathway in Azoarcus evansii: studies on the non-oxygenolytic ring cleavage enzyme.
Molecular microbiology 2005;56(6):1586-600.
2005: Fischer Markus; Haase Ilka; Feicht Richard; Schramek Nicholas; Köhler Peter; Schieberle Peter; Bacher Adelbert
Evolution of vitamin B2 biosynthesis: riboflavin synthase of Arabidopsis thaliana and its inhibition by riboflavin.
Biological chemistry 2005;386(5):417-28.
2005: Margl Lilla; Ettenhuber Christian; Gyurján István; Zenk Meinhart H; Bacher Adelbert; Eisenreich Wolfgang
Biosynthesis of benzofuran derivatives in root cultures of Tagetes patula via phenylalanine and 1-deoxy-D-xylulose 5-phosphate.
Phytochemistry 2005;66(8):887-99.
2005: Schleicher Erik; Hessling Benedikt; Illarionova Viktoria; Bacher Adelbert; Weber Stefan; Richter Gerald; Gerwert Klaus
Light-induced reactions of Escherichia coli DNA photolyase monitored by Fourier transform infrared spectroscopy.
The FEBS journal 2005;272(8):1855-66.
2005: Gliko Olga; Neumaier Nikolaus; Pan Weichun; Haase Ilka; Fischer Markus; Bacher Adelbert; Weinkauf Sevil; Vekilov Peter G
A metastable prerequisite for the growth of lumazine synthase crystals.
Journal of the American Chemical Society 2005;127(10):3433-8.
2005: Morgunova Ekaterina; Meining Winfried; Illarionov Boris; Haase Ilka; Jin Guangyi; Bacher Adelbert; Cushman Mark; Fischer Markus; Ladenstein Rudolf
Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors.
Biochemistry 2005;44(8):2746-58.
2005: Chen Jinhua; Illarionov Boris; Bacher Adelbert; Fischer Markus; Haase Ilka; Georg Gunda; Ye Qi-Zhuang; Ma Zeqiang; Cushman Mark
A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors.
Analytical biochemistry 2005;338(1):124-30.
2005: Illarionov Boris; Haase Ilka; Fischer Markus; Bacher Adelbert; Schramek Nicholas
Pre-steady-state kinetic analysis of riboflavin synthase using a pentacyclic reaction intermediate as substrate.
Biological chemistry 2005;386(2):127-36.
2005: Weber Stefan; Kay Christopher W M; Bacher Adelbert; Richter Gerald; Bittl Robert
Probing the N(5)-H bond of the isoalloxazine moiety of flavin radicals by X- and W-band pulsed electron-nuclear double resonance.
Chemphyschem : a European journal of chemical physics and physical chemistry 2005;6(2):292-9.
2005: Ettenhuber Christian; Radykewicz Tanja; Kofer Waltraud; Koop Hans-Ulrich; Bacher Adelbert; Eisenreich Wolfgang
Metabolic flux analysis in complex isotopolog space. Recycling of glucose in tobacco plants.
Phytochemistry 2005;66(3):323-35.
2005: Kemp Lauris E; Alphey Magnus S; Bond Charles S; Ferguson Michael A J; Hecht Stefan; Bacher Adelbert; Eisenreich Wolfgang; Rohdich Felix; Hunter William N
The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 1):45-52.
2005: Adam Petra; Gütlich Markus; Oschkinat Hartmut; Bacher Adelbert; Eisenreich Wolfgang
Studies of the intermediary metabolism in cultured cells of the insect Spodoptera frugiperda using 13C- or 15N-labelled tracers.
BMC biochemistry 2005;6():24.
2004: Gabrielsen Mads; Bond Charles S; Hallyburton Irene; Hecht Stefan; Bacher Adelbert; Eisenreich Wolfgang; Rohdich Felix; Hunter William N
Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis.
The Journal of biological chemistry 2004;279(50):52753-61.
2004: Bonin Irena; Robelek Rudolf; Benecke Heike; Urlaub Henning; Bacher Adelbert; Richter Gerald; Wahl Markus C
Crystal structures of the antitermination factor NusB from Thermotoga maritima and implications for RNA binding.
The Biochemical journal 2004;383(Pt. 3):419-28.
2004: Werner Roland A; Rossmann Andreas; Schwarz Christine; Bacher Adelbert; Schmidt Hanns-Ludwig; Eisenreich Wolfgang
Biosynthesis of gallic acid in Rhus typhina: discrimination between alternative pathways from natural oxygen isotope abundance.
Phytochemistry 2004;65(20):2809-13.
2004: Chen Jinhua; Sambaiah Thota; Illarionov Boris; Fischer Markus; Bacher Adelbert; Cushman Mark
Design, synthesis, and evaluation of acyclic C-nucleoside and N-methylated derivatives of the ribitylaminopyrimidine substrate of lumazine synthase as potential enzyme inhibitors and mechanistic probes.
The Journal of organic chemistry 2004;69(21):6996-7003.
2004: Gräwert Tobias; Kaiser Johannes; Zepeck Ferdinand; Laupitz Ralf; Hecht Stefan; Amslinger Sabine; Schramek Nicholas; Schleicher Erik; Weber Stefan; Haslbeck Martin; Buchner Johannes; Rieder Christoph; Arigoni Duilio; Bacher Adelbert; Eisenreich Wolfgang; Rohdich Felix
IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis.
Journal of the American Chemical Society 2004;126(40):12847-55.
2004: Zaar Annette; Gescher Johannes; Eisenreich Wolfgang; Bacher Adelbert; Fuchs Georg
New enzymes involved in aerobic benzoate metabolism in Azoarcus evansii.
Molecular microbiology 2004;54(1):223-38.
2004: Fischer Markus; Schott Anne-Kathrin; Römisch Werner; Ramsperger Arne; Augustin Martin; Fidler Alexander; Bacher Adelbert; Richter Gerald; Huber Robert; Eisenreich Wolfgang
Evolution of vitamin B2 biosynthesis. A novel class of riboflavin synthase in Archaea.
Journal of molecular biology 2004;343(1):267-78.
2004: Rohdich Felix; Bacher Adelbert; Eisenreich Wolfgang
Perspectives in anti-infective drug design. The late steps in the biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate.
Bioorganic chemistry 2004;32(5):292-308.
2004: Laupitz Ralf; Gräwert Tobias; Rieder Christoph; Zepeck Ferdinand; Bacher Adelbert; Arigoni Duilio; Rohdich Felix; Eisenreich Wolfgang
Stereochemical studies on the making and unmaking of isopentenyl diphosphate in different biological systems.
Chemistry & biodiversity 2004;1(9):1367-76.
2004: Bonin Irena; Mühlberger Rene; Bourenkov Gleb P; Huber Robert; Bacher Adelbert; Richter Gerald; Wahl Markus C
Structural basis for the interaction of Escherichia coli NusA with protein N of phage lambda.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(38):13762-7.
2004: Schleicher Erik; Kowalczyk Radoslaw M; Kay Christopher W M; Hegemann Peter; Bacher Adelbert; Fischer Markus; Bittl Robert; Richter Gerald; Weber Stefan
On the reaction mechanism of adduct formation in LOV domains of the plant blue-light receptor phototropin.
Journal of the American Chemical Society 2004;126(35):11067-76.
2004: Echt Stefanie; Bauer Stefanie; Steinbacher Stefan; Huber Robert; Bacher Adelbert; Fischer Markus
Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans.
Journal of molecular biology 2004;341(4):1085-96.
2004: Illarionov Boris; Fischer Markus; Lee Chan Yong; Bacher Adelbert; Eisenreich Wolfgang
Rapid preparation of isotopolog libraries by in vivo transformation of 1)C-glucose. Studies on 6,7-dimethyl-8-ribityllumazine, a biosynthetic precursor of vitamin B2.
The Journal of organic chemistry 2004;69(17):5588-94.
2004: Koch Michael; Breithaupt Constanze; GerhardtHaase StefanIlka; Weber Stefan; Cushman Mark; Huber Robert; Bacher Adelbert; Fischer Markus
Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase.
European journal of biochemistry / FEBS 2004;271(15):3208-14.
2004: Fischer Markus; Römisch Werner; Saller Sabine; Illarionov Boris; Richter Gerald; Rohdich Felix; Eisenreich Wolfgang; Bacher Adelbert
Evolution of vitamin B2 biosynthesis: structural and functional similarity between pyrimidine deaminases of eubacterial and plant origin.
The Journal of biological chemistry 2004;279(35):36299-308.
2004: Güldener Ulrich; Koehler Gabriele J; Haussmann Christoph; Bacher Adelbert; Kricke Jörn; Becher Dietmar; Hegemann Johannes H
Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth.
Molecular biology of the cell 2004;15(8):3811-28.
2004: Gabrielsen Mads; Rohdich Felix; Eisenreich Wolfgang; Gräwert Tobias; Hecht Stefan; Bacher Adelbert; Hunter William N
Biosynthesis of isoprenoids: a bifunctional IspDF enzyme from Campylobacter jejuni.
European journal of biochemistry / FEBS 2004;271(14):3028-35.
2004: Steinbacher Stefan; Schiffmann Susanne; Bacher Adelbert; Fischer Markus
Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 7):1338-40.
2004: Laupitz Ralf; Hecht Stefan; Amslinger Sabine; Zepeck Ferdinand; Kaiser Johannes; Richter Gerald; Schramek Nicholas; Steinbacher Stefan; Huber Robert; Arigoni Duilio; Bacher Adelbert; Eisenreich Wolfgang; Rohdich Felix
Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways.
European journal of biochemistry / FEBS 2004;271(13):2658-69.
2004: Eisenreich W; Bacher A; Arigoni D; Rohdich F
Biosynthesis of isoprenoids via the non-mevalonate pathway.
Cellular and molecular life sciences : CMLS 2004;61(12):1401-26.
2004: Bauer Stefanie; Schott Ann-Kathrin; Illarionova Victoria; Bacher Adelbert; Huber Robert; Fischer Markus
Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class.
Journal of molecular biology 2004;339(4):967-79.
2004: Bader Gerd; Gomez-Ortiz Mariola; Haussmann Christoph; Bacher Adelbert; Huber Robert; Fischer Markus
Structure of the molybdenum-cofactor biosynthesis protein MoaB of Escherichia coli.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 6):1068-75.
2004: Goyer Aymeric; Illarionova Victoria; Roje Sanja; Fischer Markus; Bacher Adelbert; Hanson Andrew D
Folate biosynthesis in higher plants. cDNA cloning, heterologous expression, and characterization of dihydroneopterin aldolases.
Plant physiology 2004;135(1):103-11.
2004: Hecht Stefan; Kammhuber Klaus; Reiner Josef; Bacher Adelbert; Eisenreich Wolfgang
Biosynthetic experiments with tall plants under field conditions. 18O2 incorporation into humulone from Humulus lupulus.
Phytochemistry 2004;65(8):1057-60.
2004: Eisenreich Wolfgang; Ettenhuber Christian; Laupitz Ralf; Theus Cornelia; Bacher Adelbert
Isotopolog perturbation techniques for metabolic networks: metabolic recycling of nutritional glucose in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6764-9.
2004: Eisenreich Wolfgang; Kemter Kristina; Bacher Adelbert; Mulrooney Scott B; Williams Charles H; Müller Franz
13C-, 15N- and 31P-NMR studies of oxidized and reduced low molecular mass thioredoxin reductase and some mutant proteins.
European journal of biochemistry / FEBS 2004;271(8):1437-52.
2004: Cushman Mark; Sambaiah Thota; Jin Guangyi; Illarionov Boris; Fischer Markus; Bacher Adelbert
Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of tiboflavin synthase and lumazine synthase.
The Journal of organic chemistry 2004;69(3):601-12.
2003: Fischer Markus; Schott Ann-Kathrin; Kemter Kristina; Feicht Richard; Richter Gerald; Illarionov Boris; Eisenreich Wolfgang; Gerhardt Stefan; Cushman Mark; Steinbacher Stefan; Huber Robert; Bacher Adelbert
Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments.
BMC biochemistry 2003;4():18.
2003: Illarionov Boris; Haase Ilka; Bacher Adelbert; Fischer Markus; Schramek Nicholas
Presteady state kinetic analysis of riboflavin synthase.
The Journal of biological chemistry 2003;278(48):47700-6.
2003: Steinbacher Stefan; Schiffmann Susanne; Richter Gerald; Huber Robert; Bacher Adelbert; Fischer Markus
Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism.
The Journal of biological chemistry 2003;278(43):42256-65.
2003: Eisenreich Wolfgang; Kupfer Ernst; Stohler Peter; Weber Wolfgang; Bacher Adelbert
Biosynthetic origin of a branched chain analogue of the lipase inhibitor, lipstatin.
Journal of medicinal chemistry 2003;46(19):4209-12.
2003: Haase Ilka; Fischer Markus; Bacher Adelbert; Schramek Nicholas
Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
The Journal of biological chemistry 2003;278(39):37909-15.
2003: Meining Winfried; Eberhardt Sabine; Bacher Adelbert; Ladenstein Rudolf
The structure of the N-terminal domain of riboflavin synthase in complex with riboflavin at 2.6A resolution.
Journal of molecular biology 2003;331(5):1053-63.
2003: Gerhardt Stefan; Echt Stefanie; Busch Marco; Freigang Jörg; Auerbach Günter; Bader Gerd; Martin William F; Bacher Adelbert; Huber Robert; Fischer Markus
Structure and properties of an engineered transketolase from maize.
Plant physiology 2003;132(4):1941-9.
2003: Miallau Linda; Alphey Magnus S; Kemp Lauris E; Leonard Gordon A; McSweeney Sean M; Hecht Stefan; Bacher Adelbert; Eisenreich Wolfgang; Rohdich Felix; Hunter William N
Biosynthesis of isoprenoids: crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9173-8.
2003: Ismail Wael; El-Said Mohamed Magdy; Wanner Barry L; Datsenko Kirill A; Eisenreich Wolfgang; Rohdich Felix; Bacher Adelbert; Fuchs Georg
Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli.
European journal of biochemistry / FEBS 2003;270(14):3047-54.
2003: Wang Chang-Zeng; Maier Ulrich H; Keil Michael; Zenk Meinhart H; Bacher Adelbert; Rohdich Felix; Eisenreich Wolfgang
Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone. A retrobiosynthetic NMR study with root cultures of Swertia chirata.
European journal of biochemistry / FEBS 2003;270(14):2950-8.
2003: Steinbacher Stefan; Kaiser Johannes; Gerhardt Stefan; Eisenreich Wolfgang; Huber Robert; Bacher Adelbert; Rohdich Felix
Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis.
Journal of molecular biology 2003;329(5):973-82.
2003: Steinbacher Stefan; Kaiser Johannes; Eisenreich Wolfgang; Huber Robert; Bacher Adelbert; Rohdich Felix
Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.
The Journal of biological chemistry 2003;278(20):18401-7.
2003: Zhang Xiaofeng; Meining Winfried; Cushman Mark; Haase Ilka; Fischer Markus; Bacher Adelbert; Ladenstein Rudolf
A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus.
Journal of molecular biology 2003;328(1):167-82.
2003: Schramek Nicholas; Haase Ilka; Fischer Markus; Bacher Adelbert
Biosynthesis of riboflavin. Single turnover kinetic analysis of 6,7-dimethyl-8-ribityllumazine synthase.
Journal of the American Chemical Society 2003;125(15):4460-6.
2003: Mühlberger René; Robelek Rudolf; Eisenreich Wolfgang; Ettenhuber Christian; Sinner Eva Kathrin; Kessler Horst; Bacher Adelbert; Richter Gerald
RNA DNA discrimination by the antitermination protein NusB.
Journal of molecular biology 2003;327(5):973-83.
2003: Haase Ilka; Mörtl Simone; Köhler Peter; Bacher Adelbert; Fischer Markus
Biosynthesis of riboflavin in archaea. 6,7-dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii.
European journal of biochemistry / FEBS 2003;270(5):1025-32.
2003: Bauer Stefanie; Kemter Kristina; Bacher Adelbert; Huber Robert; Fischer Markus; Steinbacher Stefan
Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold.
Journal of molecular biology 2003;326(5):1463-73.
2003: Kay Christopher W M; Schleicher Erik; Kuppig Andreas; Hofner Heidi; Rüdiger Wolfhart; Schleicher Michael; Fischer Markus; Bacher Adelbert; Weber Stefan; Richter Gerald
Blue light perception in plants. Detection and characterization of a light-induced neutral flavin radical in a C450A mutant of phototropin.
The Journal of biological chemistry 2003;278(13):10973-82.
2003: Fischer Markus; Haase Ilka; Kis Klaus; Meining Winfried; Ladenstein Rudolf; Cushman Mark; Schramek Nicholas; Huber Robert; Bacher Adelbert
Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase.
Journal of molecular biology 2003;326(3):783-93.
2003: Rohdich Felix; Zepeck Ferdinand; Adam Petra; Hecht Stefan; Kaiser Johannes; Laupitz Ralf; Gräwert Tobias; Amslinger Sabine; Eisenreich Wolfgang; Bacher Adelbert; Arigoni Duilio
The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1586-91.
2003: Rebelo Jorge; Auerbach Günter; Bader Gerd; Bracher Andreas; Nar Herbert; Hösl Cornelia; Schramek Nicholas; Kaiser Johannes; Bacher Adelbert; Huber Robert; Fischer Markus
Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I.
Journal of molecular biology 2003;326(2):503-16.
2002: Glawischnig Erich; Gierl Alfons; Tomas Adriana; Bacher Adelbert; Eisenreich Wolfgang
Starch biosynthesis and intermediary metabolism in maize kernels. Quantitative analysis of metabolite flux by nuclear magnetic resonance.
Plant physiology 2002;130(4):1717-27.
2002: Römisch Werner; Eisenreich Wolfgang; Richter Gerald; Bacher Adelbert
Rapid one-pot synthesis of riboflavin isotopomers.
The Journal of organic chemistry 2002;67(25):8890-4.
2002: Kaiser Johannes; Schramek Nicholas; Eberhardt Sabine; Püttmer Stefanie; Schuster Michael; Bacher Adelbert
Biosynthesis of vitamin B2.
European journal of biochemistry / FEBS 2002;269(21):5264-70.
2002: Fischer Markus; Romisch Werner; Schiffmann Susanne; Kelly Mark; Oschkinat Hartmut; Steinbacher Stefan; Huber Robert; Eisenreich Wolfgang; Richter Gerald; Bacher Adelbert
Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii.
The Journal of biological chemistry 2002;277(44):41410-6.
2002: Gerhardt Stefan; Schott Ann-Kathrin; Kairies Norman; Cushman Mark; Illarionov Boris; Eisenreich Wolfgang; Bacher Adelbert; Huber Robert; Steinbacher Stefan; Fischer Markus
Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine.
Structure (London, England : 1993) 2002;10(10):1371-81.
2002: Adam Petra; Arigoni Duilio; Bacher Adelbert; Eisenreich Wolfgang
Biosynthesis of hyperforin in Hypericum perforatum.
Journal of medicinal chemistry 2002;45(21):4786-93.
2002: Cushman Mark; Yang Donglai; Mihalic Jeffrey T; Chen Jinhua; Gerhardt Stefan; Huber Robert; Fischer Markus; Kis Klaus; Bacher Adelbert
Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase.
The Journal of organic chemistry 2002;67(20):6871-7.
2002: Basset Gilles; Quinlivan Eoin P; Ziemak Michael J; Diaz De La Garza Rocio; Fischer Markus; Schiffmann Susi; Bacher Adelbert; Gregory Jesse F; Hanson Andrew D
Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12489-94.
2002: Adam Petra; Hecht Stefan; Eisenreich Wolfgang; Kaiser Johannes; Grawert Tobias; Arigoni Duilio; Bacher Adelbert; Rohdich Felix
Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12108-13.
2002: Cushman Mark; Yang Donglai; Gerhardt Stefan; Huber Robert; Fischer Markus; Kis Klaus; Bacher Adelbert
Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase.
The Journal of organic chemistry 2002;67(16):5807-16.
2002: Braun Nathalie; Meining Winfried; Hars Ulrike; Fischer Markus; Ladenstein Rudolf; Huber Robert; Bacher Adelbert; Weinkauf Sevil; Bachmann Luis
Formation of metal nanoclusters on specific surface sites of protein molecules.
Journal of molecular biology 2002;321(2):341-53.
2002: Illarionova Victoria; Eisenreich Wolfgang; Fischer Markus; Haussmann Christoph; Romisch Werner; Richter Gerald; Bacher Adelbert
Biosynthesis of tetrahydrofolate. Stereochemistry of dihydroneopterin aldolase.
The Journal of biological chemistry 2002;277(32):28841-7.
2002: Amslinger Sabine; Kis Klaus; Hecht Stefan; Adam Petra; Rohdich Felix; Arigoni Duilio; Bacher Adelbert; Eisenreich Wolfgang
Biosynthesis of terpenes. Preparation of (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate, an intermediate of the deoxyxylulose phosphate pathway.
The Journal of organic chemistry 2002;67(13):4590-4.
2002: Herter Sylvia; Fuchs Georg; Bacher Adelbert; Eisenreich Wolfgang
A bicyclic autotrophic CO2 fixation pathway in Chloroflexus aurantiacus.
The Journal of biological chemistry 2002;277(23):20277-83.
2002: Gerhardt Stefan; Haase Ilka; Steinbacher Stefan; Kaiser Jens T; Cushman Mark; Bacher Adelbert; Huber Robert; Fischer Markus
The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase.
Journal of molecular biology 2002;318(5):1317-29.
2002: Herz Stefan; Kis Klaus; Bacher Adelbert; Rohdich Felix
A tomato enzyme catalyzing the phosphorylation of 3,4-dihydroxy-2-butanone.
Phytochemistry 2002;60(1):3-11.
2002: Schuhr Christoph A; Eisenreich Wolfgang; Goese Markus; Stohler Peter; Weber Wolfgang; Kupfer Ernst; Bacher Adelbert
Biosynthetic precursors of the lipase inhibitor lipstatin.
The Journal of organic chemistry 2002;67(7):2257-62.
2002: Mehta Anil K; Studelska Daniel R; Fischer Markus; Giessauf Andreas; Kemter Kristina; Bacher Adelbert; Cushman Mark; Schaefer Jacob
Investigation of the binding of epimer A of the covalent hydrate of 6,7-bis(trifluoromethyl)-8-D-ribityllumazine to a recombinant F22W Bacillus subtilis lumazine synthase mutant by (15)N[(19)F] REDOR NMR.
The Journal of organic chemistry 2002;67(7):2087-92.
2002: Lüttgen Holger; Robelek Rudolf; Mühlberger René; Diercks Tammo; Schuster Stephan C; Köhler Peter; Kessler Horst; Bacher Adelbert; Richter Gerald
Transcriptional regulation by antitermination. Interaction of RNA with NusB protein and NusB/NusE protein complex of Escherichia coli.
Journal of molecular biology 2002;316(4):875-85.
2002: Schramek Nicholas; Bracher Andreas; Fischer Markus; Auerbach Günter; Nar Herbert; Huber Robert; Bacher Adelbert
Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate.
Journal of molecular biology 2002;316(3):829-37.
2002: Eisenreich Wolfgang; Bacher Adelbert; Berry Alan; Bretzel Werner; Hümbelin Markus; Lopez-Ulibarri Rual; Mayer Anne F; Yeliseev Alexei
Biosynthesis of zeaxanthin via mevalonate in Paracoccus species strain PTA-3335. A product-based retrobiosynthetic study.
The Journal of organic chemistry 2002;67(3):871-5.
2002: Steinbacher Stefan; Kaiser Johannes; Wungsintaweekul Juraithip; Hecht Stefan; Eisenreich Wolfgang; Gerhardt Stefan; Bacher Adelbert; Rohdich Felix
Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids.
Journal of molecular biology 2002;316(1):79-88.
2002: Rohdich Felix; Hecht Stefan; Gärtner Katrin; Adam Petra; Krieger Cornelia; Amslinger Sabine; Arigoni Duilio; Bacher Adelbert; Eisenreich Wolfgang
Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1158-63.
2002: Holdengreber Vered; Krieger Cornelia; Gütlich Markus; Schramek Nikolas; Vechoropoulos Michal; Fischer Markus; Bacher Adelbert; Ben-Shaul Yehuda
Localization of two enzymes of the tetrahydrobiopterin biosynthetic pathway in embryonic chick retina.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002;50(2):265-74.
2002: Fischer Markus; Haase Ilka; Feicht Richard; Richter Gerald; Gerhardt Stefan; Changeux Jean-Pierre; Huber Robert; Bacher Adelbert
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
European journal of biochemistry / FEBS 2002;269(2):519-26.
2001: Hecht S; Eisenreich W; Adam P; Amslinger S; Kis K; Bacher A; Arigoni D; Rohdich F
Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14837-42.
2001: Cushman M; Yang D; Kis K; Bacher A
Design, synthesis, and evaluation of 9-D-ribityl-1,3,7-trihydro-2,6,8-purinetrione, a potent inhibitor of riboflavin synthase and lumazine synthase.
The Journal of organic chemistry 2001;66(25):8320-7.
2001: Fellermeier M; Raschke M; Sagner S; Wungsintaweekul J; Schuhr C A; Hecht S; Kis K; Radykewicz T; Adam P; Rohdich F; Eisenreich W; Bacher A; Arigoni D; Zenk M H
Studies on the nonmevalonate pathway of terpene biosynthesis. The role of 2C-methyl-D-erythritol 2,4-cyclodiphosphate in plants.
European journal of biochemistry / FEBS 2001;268(23):6302-10.
2001: Hecht S; Wungsintaweekul J; Rohdich F; Kis K; Radykewicz T; Schuhr C A; Eisenreich W; Richter G; Bacher A
Biosynthesis of terpenoids: efficient multistep biotransformation procedures affording isotope-labeled 2C-methyl-D-erythritol 4-phosphate using recombinant 2C-methyl-D-erythritol 4-phosphate synthase.
The Journal of organic chemistry 2001;66(23):7770-5.
2001: Kelly M J; Ball L J; Krieger C; Yu Y; Fischer M; Schiffmann S; Schmieder P; Kühne R; Bermel W; Bacher A; Richter G; Oschkinat H
The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13025-30.
2001: Margl L; Eisenreich W; Adam P; Bacher A; Zenk M H
Biosynthesis of thiophenes in Tagetes patula.
Phytochemistry 2001;58(6):875-81.
2001: Schramek N; Bracher A; Bacher A
Biosynthesis of riboflavin. Single turnover kinetic analysis of GTP cyclohydrolase II.
The Journal of biological chemistry 2001;276(47):44157-62.
2001: Salomon M; Eisenreich W; Dürr H; Schleicher E; Knieb E; Massey V; Rüdiger W; Müller F; Bacher A; Richter G
An optomechanical transducer in the blue light receptor phototropin from Avena sativa.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12357-61.
2001: Bader G; Schiffmann S; Herrmann A; Fischer M; Gütlich M; Auerbach G; Ploom T; Bacher A; Huber R; Lemm T
Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP.
Journal of molecular biology 2001;312(5):1051-7.
2001: Rohdich F; Kis K; Bacher A; Eisenreich W
The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates.
Current opinion in chemical biology 2001;5(5):535-40.
2001: Meining W; Eberhardt S; Bacher A; Ladenstein R
Crystallization and preliminary crystallographic analysis of the recombinant N-terminal domain of riboflavin synthase.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 9):1296-9.
2001: Eberhardt S; Zingler N; Kemter K; Richter G; Cushman M; Bacher A
Domain structure of riboflavin synthase.
European journal of biochemistry / FEBS 2001;268(15):4315-23.
2001: Weber S; Richter G; Schleicher E; Bacher A; Möbius K; Kay C W
Substrate binding to DNA photolyase studied by electron paramagnetic resonance spectroscopy.
Biophysical journal 2001;81(2):1195-204.
2001: Bracher A; Schramek N; Bacher A
Biosynthesis of pteridines. Stopped-flow kinetic analysis of GTP cyclohydrolase I.
Biochemistry 2001;40(26):7896-902.
2001: Herter S; Farfsing J; Gad'On N; Rieder C; Eisenreich W; Bacher A; Fuchs G
Autotrophic CO(2) fixation by Chloroflexus aurantiacus: study of glyoxylate formation and assimilation via the 3-hydroxypropionate cycle.
Journal of bacteriology 2001;183(14):4305-16.
2001: Zaar A; Eisenreich W; Bacher A; Fuchs G
A novel pathway of aerobic benzoate catabolism in the bacteria Azoarcus evansii and Bacillus stearothermophilus.
The Journal of biological chemistry 2001;276(27):24997-5004.
2001: Goese M; Eisenreich W; Kupfer E; Stohler P; Weber W; Leuenberger H G; Bacher A
Biosynthesis of lipstatin. Incorporation of multiply deuterium-labeled (5Z,8Z)-tetradeca-5,8-dienoic acid and octanoic acid.
The Journal of organic chemistry 2001;66(13):4673-8.
2001: Illarionov B; Eisenreich W; Bacher A
A pentacyclic reaction intermediate of riboflavin synthase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7224-9.
2001: Truffault V; Coles M; Diercks T; Abelmann K; Eberhardt S; Lüttgen H; Bacher A; Kessler H
The solution structure of the N-terminal domain of riboflavin synthase.
Journal of molecular biology 2001;309(4):949-60.
2001: Rohdich F; Eisenreich W; Wungsintaweekul J; Hecht S; Schuhr C A; Bacher A
Biosynthesis of terpenoids. 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum.
European journal of biochemistry / FEBS 2001;268(11):3190-7.
2001: Hecht S; Kis K; Eisenreich W; Amslinger S; Wungsintaweekul J; Herz S; Rohdich F; Bacher A
Enzyme-assisted preparation of isotope-labeled 1-deoxy-d-xylulose 5-phosphate.
The Journal of organic chemistry 2001;66(11):3948-52.
2001: Scheuring J; Kugelbrey K; Weinkauf S; Cushman M; Bacher A; Fischer M
19F NMR ligand perturbation studies on 6,7-bis(trifluoromethyl)-8-ribityllumazine-7-hydrates and the lumazine synthase complex of Bacillus subtilis. Site-directed mutagenesis changes the mechanism and the stereoselectivity of the catalyzed haloform-type reaction.
The Journal of organic chemistry 2001;66(11):3811-9.
2001: Ritz H; Schramek N; Bracher A; Herz S; Eisenreich W; Richter G; Bacher A
Biosynthesis of riboflavin: studies on the mechanism of GTP cyclohydrolase II.
The Journal of biological chemistry 2001;276(25):22273-7.
2001: Kis K; Kugelbrey K; Bacher A
Biosynthesis of riboflavin. The reaction catalyzed by 6,7-dimethyl-8-ribityllumazine synthase can proceed without enzymatic catalysis under physiological conditions.
The Journal of organic chemistry 2001;66(8):2555-9.
2001: Illarionov B; Kemter K; Eberhardt S; Richter G; Cushman M; Bacher A
Riboflavin synthase of Escherichia coli. Effect of single amino acid substitutions on reaction rate and ligand binding properties.
The Journal of biological chemistry 2001;276(15):11524-30.
2001: Fellermeier M; Eisenreich W; Bacher A; Zenk M H
Biosynthesis of cannabinoids. Incorporation experiments with (13)C-labeled glucoses.
European journal of biochemistry / FEBS 2001;268(6):1596-604.
2001: Fischer M; Corringer P J; Schott K; Bacher A; Changeux J P
A method for soluble overexpression of the alpha7 nicotinic acetylcholine receptor extracellular domain.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3567-70.
2001: Glawischnig E; Gierl A; Tomas A; Bacher A; Eisenreich W
Retrobiosynthetic nuclear magnetic resonance analysis of amino acid biosynthesis and intermediary metabolism. Metabolic flux in developing maize kernels.
Plant physiology 2001;125(3):1178-86.
2001: Zhang X; Meining W; Fischer M; Bacher A; Ladenstein R
X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 A resolution: determinants of thermostability revealed from structural comparisons.
Journal of molecular biology 2001;306(5):1099-114.
2001: Eisenreich W; Rohdich F; Bacher A
Deoxyxylulose phosphate pathway to terpenoids.
Trends in plant science 2001;6(2):78-84.
2001: Rohdich F; Wiese A; Feicht R; Simon H; Bacher A
Enoate reductases of Clostridia. Cloning, sequencing, and expression.
The Journal of biological chemistry 2001;276(8):5779-87.
2001: Wungsintaweekul J; Herz S; Hecht S; Eisenreich W; Feicht R; Rohdich F; Bacher A; Zenk M H
Phosphorylation of 1-deoxy-D-xylulose by D-xylulokinase of Escherichia coli.
European journal of biochemistry / FEBS 2001;268(2):310-6.
2001: Schramek N; Bracher A; Bacher A
Ring opening is not rate-limiting in the GTP cyclohydrolase I reaction.
The Journal of biological chemistry 2001;276(4):2622-6.
2001: Bacher A; Eberhardt S; Eisenreich W; Fischer M; Herz S; Illarionov B; Kis K; Richter G
Biosynthesis of riboflavin.
Vitamins and hormones 2001;61():1-49.
2000: Auerbach G; Herrmann A; Bracher A; Bader G; Gutlich M; Fischer M; Neukamm M; Garrido-Franco M; Richardson J; Nar H; Huber R; Bacher A
Zinc plays a key role in human and bacterial GTP cyclohydrolase I.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13567-72.
2000: Glawischnig E; Tomas A; Eisenreich W; Spiteller P; Bacher A; Gierl A
Auxin biosynthesis in maize kernels.
Plant physiology 2000;123(3):1109-19.
2000: Rohdich F; Wungsintaweekul J; Luttgen H; Fischer M; Eisenreich W; Schuhr C A; Fellermeier M; Schramek N; Zenk M H; Bacher A
Biosynthesis of terpenoids: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from tomato.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8251-6.
2000: Goese M; Eisenreich W; Kupfer E; Weber W; Bacher A
Biosynthetic origin of hydrogen atoms in the lipase inhibitor lipstatin.
The Journal of biological chemistry 2000;275(28):21192-6.
2000: Boll M; Laempe D; Eisenreich W; Bacher A; Mittelberger T; Heinze J; Fuchs G
Nonaromatic products from anoxic conversion of benzoyl-CoA with benzoyl-CoA reductase and cyclohexa-1,5-diene-1-carbonyl-CoA hydratase.
The Journal of biological chemistry 2000;275(29):21889-95.
2000: Rohdich F; Wungsintaweekul J; Eisenreich W; Richter G; Schuhr C A; Hecht S; Zenk M H; Bacher A
Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6451-6.
2000: Meining W; Mörtl S; Fischer M; Cushman M; Bacher A; Ladenstein R
The atomic structure of pentameric lumazine synthase from Saccharomyces cerevisiae at 1.85 A resolution reveals the binding mode of a phosphonate intermediate analogue.
Journal of molecular biology 2000;299(1):181-97.
2000: Herz S; Eberhardt S; Bacher A
Biosynthesis of riboflavin in plants. The ribA gene of Arabidopsis thaliana specifies a bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase.
Phytochemistry 2000;53(7):723-31.
2000: Herz S; Wungsintaweekul J; Schuhr C A; Hecht S; Luttgen H; Sagner S; Fellermeier M; Eisenreich W; Zenk M H; Bacher A; Rohdich F
Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2486-90.
2000: Lüttgen H; Rohdich F; Herz S; Wungsintaweekul J; Hecht S; Schuhr C A; Fellermeier M; Sagner S; Zenk M H; Bacher A; Eisenreich W
Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1062-7.
2000: Radykewicz T; Rohdich F; Wungsintaweekul J; Herz S; Kis K; Eisenreich W; Bacher A; Zenk M H; Arigoni D
Biosynthesis of terpenoids: 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Escherichia coli is a class B dehydrogenase.
FEBS letters 2000;465(2-3):157-60.
2000: Bacher A; Eberhardt S; Fischer M; Kis K; Richter G
Biosynthesis of vitamin b2 (riboflavin).
Annual review of nutrition 2000;20():153-67.
1999: Kay C W; Feicht R; Schulz K; Sadewater P; Sancar A; Bacher A; Möbius K; Richter G; Weber S
EPR, ENDOR, and TRIPLE resonance spectroscopy on the neutral flavin radical in Escherichia coli DNA photolyase.
Biochemistry 1999;38(51):16740-8.
1999: Eisenreich W; Rieder C; Grammes C; Hessler G; Adam K P; Becker H; Arigoni D; Bacher A
Biosynthesis of a neo-epi-verrucosane diterpene in the liverwort Fossombronia alaskana. A retrobiosynthetic NMR study.
The Journal of biological chemistry 1999;274(51):36312-20.
1999: Rohdich F; Wungsintaweekul J; Fellermeier M; Sagner S; Herz S; Kis K; Eisenreich W; Bacher A; Zenk M H
Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11758-63.
1999: Goese M; Kammhuber K; Bacher A; Zenk M H; Eisenreich W
Biosynthesis of bitter acids in hops. A (13)C-NMR and (2)H-NMR study on the building blocks of humulone.
European journal of biochemistry / FEBS 1999;263(2):447-54.
1999: Bracher A; Fischer M; Eisenreich W; Ritz H; Schramek N; Boyle P; Gentili P; Huber R; Nar H; Auerbach G; Bacher A
Histidine 179 mutants of GTP cyclohydrolase I catalyze the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone triphosphate.
The Journal of biological chemistry 1999;274(24):16727-35.
1999: Kelly M J; Krieger C; Ball L J; Yu Y; Richter G; Schmieder P; Bacher A; Oschkinat H
Application of amino acid type-specific 1H- and 14N-labeling in a 2H-, 15N-labeled background to a 47 kDa homodimer: potential for NMR structure determination of large proteins.
Journal of biomolecular NMR 1999;14(1):79-83.
1999: Ploom T; Haussmann C; Hof P; Steinbacher S; Bacher A; Richardson J; Huber R
Crystal structure of 7,8-dihydroneopterin triphosphate epimerase.
Structure (London, England : 1993) 1999;7(5):509-16.
1999: Richter G; Kelly M; Krieger C; Yu Y; Bermel W; Karlsson G; Bacher A; Oschkinat H
NMR studies on the 46-kDa dimeric protein, 3,4-dihydroxy-2-butanone 4-phosphate synthase, using 2H, 13C, and 15N-labelling.
European journal of biochemistry / FEBS 1999;261(1):57-65.
1999: Mancini R; Saracino F; Buscemi G; Fischer M; Schramek N; Bracher A; Bacher A; Gütlich M; Carbone M L
Complementation of the fol2 deletion in Saccharomyces cerevisiae by human and Escherichia coli genes encoding GTP cyclohydrolase I.
Biochemical and biophysical research communications 1999;255(2):521-7.
1999: Arigoni D; Eisenreich W; Latzel C; Sagner S; Radykewicz T; Zenk M H; Bacher A
Dimethylallyl pyrophosphate is not the committed precursor of isopentenyl pyrophosphate during terpenoid biosynthesis from 1-deoxyxylulose in higher plants.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1309-14.
1999: Cushman M; Mihalic J T; Kis K; Bacher A
Design and synthesis of 6-(6-D-ribitylamino-2,4-dihydroxypyrimidin-5-yl)-1-hexyl phosphonic acid, a potent inhibitor of lumazine synthase.
Bioorganic & medicinal chemistry letters 1999;9(1):39-42.
1998: Fellermeier M A; Maier U H; Sagner S; Bacher A; Zenk M H
(-)-2C-methyl-D-erythrono-1,4-lactone is formed after application of the terpenoid precursor 1-deoxy-D-xylulose.
FEBS letters 1998;437(3):278-80.
1998: Bracher A; Eisenreich W; Schramek N; Ritz H; Götze E; Herrmann A; Gütlich M; Bacher A
Biosynthesis of pteridines. NMR studies on the reaction mechanisms of GTP cyclohydrolase I, pyruvoyltetrahydropterin synthase, and sepiapterin reductase.
The Journal of biological chemistry 1998;273(43):28132-41.
1998: Eisenreich W; Schwarz M; Cartayrade A; Arigoni D; Zenk M H; Bacher A
The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganisms.
Chemistry & biology 1998;5(9):R221-33.
1998: Laempe D; Eisenreich W; Bacher A; Fuchs G
Cyclohexa-1,5-diene-1-carbonyl-CoA hydratase [corrected], an enzyme involved in anaerobic metabolism of benzoyl-CoA in the denitrifying bacterium Thauera aromatica.
European journal of biochemistry / FEBS 1998;255(3):618-27.
1998: Rieder C; Eisenreich W; O'Brien J; Richter G; Götze E; Boyle P; Blanchard S; Bacher A; Simon H
Rearrangement reactions in the biosynthesis of molybdopterin--an NMR study with multiply 13C/15N labelled precursors.
European journal of biochemistry / FEBS 1998;255(1):24-36.
1998: Huenges M; Rölz C; Gschwind R; Peteranderl R; Berglechner F; Richter G; Bacher A; Kessler H; Gemmecker G
Solution structure of the antitermination protein NusB of Escherichia coli: a novel all-helical fold for an RNA-binding protein.
The EMBO journal 1998;17(14):4092-100.
1998: Rieder C; Strauss G; Fuchs G; Arigoni D; Bacher A; Eisenreich W
Biosynthesis of the diterpene verrucosan-2beta-ol in the phototrophic eubacterium Chloroflexus aurantiacus. A retrobiosynthetic NMR study.
The Journal of biological chemistry 1998;273(29):18099-108.
1998: Haussmann C; Rohdich F; Schmidt E; Bacher A; Richter G
Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase.
The Journal of biological chemistry 1998;273(28):17418-24.
1998: Cushman M; Mavandadi F; Kugelbrey K; Bacher A
Synthesis of 2,6-dioxo-(1H,3H)-9-N-ribitylpurine and 2,6-dioxo-(1H,3H)-8-aza-9-N-ribitylpurine as inhibitors of lumazine synthase and riboflavin synthase.
Bioorganic & medicinal chemistry 1998;6(4):409-15.
1998: Meining W; Tibbelin G; Ladenstein R; Eberhardt S; Fischer M; Bacher A
Evidence for local 32 symmetry in homotrimeric riboflavin synthase of Escherichia coli.
Journal of structural biology 1998;121(1):53-60.
1997: Auerbach G; Herrmann A; Gütlich M; Fischer M; Jacob U; Bacher A; Huber R
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.
The EMBO journal 1997;16(24):7219-30.
1997: Werner I; Bacher A; Eisenreich W
Retrobiosynthetic NMR studies with 13C-labeled glucose. Formation of gallic acid in plants and fungi.
The Journal of biological chemistry 1997;272(41):25474-82.
1997: Arigoni D; Sagner S; Latzel C; Eisenreich W; Bacher A; Zenk M H
Terpenoid biosynthesis from 1-deoxy-D-xylulose in higher plants by intramolecular skeletal rearrangement.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10600-5.
1997: Berglechner F; Richter G; Fischer M; Bacher A; Gschwind R M; Huenges M; Gemmecker G; Kessler H
Studies on the NusB protein of Escherichia coli--expression and determination of secondary-structure elements by multinuclear NMR spectroscopy.
European journal of biochemistry / FEBS 1997;248(2):338-46.
1997: Frey M; Chomet P; Glawischnig E; Stettner C; Grün S; Winklmair A; Eisenreich W; Bacher A; Meeley R B; Briggs S P; Simcox K; Gierl A
Analysis of a chemical plant defense mechanism in grasses.
Science (New York, N.Y.) 1997;277(5326):696-9.
1997: Eberhardt S; Korn S; Lottspeich F; Bacher A
Biosynthesis of riboflavin: an unusual riboflavin synthase of Methanobacterium thermoautotrophicum.
Journal of bacteriology 1997;179(9):2938-43.
1997: Richter G; Fischer M; Krieger C; Eberhardt S; Lüttgen H; Gerstenschläger I; Bacher A
Biosynthesis of riboflavin: characterization of the bifunctional deaminase-reductase of Escherichia coli and Bacillus subtilis.
Journal of bacteriology 1997;179(6):2022-8.
1997: Haussmann C; Rohdich F; Lottspeich F; Eberhardt S; Scheuring J; Mackamul S; Bacher A
Dihydroneopterin triphosphate epimerase of Escherichia coli: purification, genetic cloning, and expression.
Journal of bacteriology 1997;179(3):949-51.
1997: Eisenreich W; Kupfer E; Weber W; Bacher A
Tracer studies with crude U-13C-lipid mixtures. Biosynthesis of the lipase inhibitor lipstatin.
The Journal of biological chemistry 1997;272(2):867-74.
1997: Bacher A; Eberhardt S; Fischer M; Mörtl S; Kis K; Kugelbrey K; Scheuring J; Schott K
Biosynthesis of riboflavin: lumazine synthase and riboflavin synthase.
Methods in enzymology 1997;280():389-99.
1997: Bacher A; Richter G; Ritz H; Eberhardt S; Fischer M; Krieger C
Biosynthesis of riboflavin: GTP cyclohydrolase II, deaminase, and reductase.
Methods in enzymology 1997;280():382-9.
1997: Richter G; Krieger C; Volk R; Kis K; Ritz H; Götze E; Bacher A
Biosynthesis of riboflavin: 3,4-dihydroxy-2-butanone-4-phosphate synthase.
Methods in enzymology 1997;280():374-82.
1996: Eberhardt S; Richter G; Gimbel W; Werner T; Bacher A
Cloning, sequencing, mapping and hyperexpression of the ribC gene coding for riboflavin synthase of Escherichia coli.
European journal of biochemistry / FEBS 1996;242(3):712-9.
1996: Mörtl S; Fischer M; Richter G; Tack J; Weinkauf S; Bacher A
Biosynthesis of riboflavin. Lumazine synthase of Escherichia coli.
The Journal of biological chemistry 1996;271(52):33201-7.
1996: Witter K; Cahill D J; Werner T; Ziegler I; Rödl W; Bacher A; Gütlich M
Molecular cloning of a cDNA coding for GTP cyclohydrolase I from Dictyostelium discoideum.
The Biochemical journal 1996;319 ( Pt 1)():27-32.
1996: Scheuring J; Fischer M; Cushman M; Lee J; Bacher A; Oschkinat H
NMR analysis of site-specific ligand binding in oligomeric proteins. Dynamic studies on the interaction of riboflavin synthase with trifluoromethyl-substituted intermediates.
Biochemistry 1996;35(30):9637-46.
1996: Eisenreich W; Menhard B; Hylands P J; Zenk M H; Bacher A
Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6431-6.
1996: Witter K; Werner T; Blusch J H; Schneider E M; Riess O; Ziegler I; Rödl W; Bacher A; Gütlich M
Cloning, sequencing and functional studies of the gene encoding human GTP cyclohydrolase I.
Gene 1996;171(2):285-90.
1996: Bacher A; Fischer M; Kis K; Kugelbrey K; Mörtl S; Scheuring J; Weinkauf S; Eberhardt S; Schmidt-Bäse K; Huber R; Ritsert K; Cushman M; Ladenstein R
Biosynthesis of riboflavin: structure and mechanism of lumazine synthase.
Biochemical Society transactions 1996;24(1):89-94.
1996: Nar H; Huber R; Meining W; Bracher A; Fischer M; Hösl C; Ritz H; Schmid C; Weinkauf S; Bacher A
Structure and mechanism of GTP cyclohydrolase I of Escherichia coli.
Biochemical Society transactions 1996;24(1):37S.
1996: Fischer M; Eberhardt S; Richter G; Krieger C; Gerstenschlåger I; Bacher A
Biosynthesis of riboflavin. Bifunctional pyrimidine deaminase/reductase of Escherichia coli and Bacillus subtilis.
Biochemical Society transactions 1996;24(1):35S.
1996: Tibbelin G; Eberhardt S; Richter G; Bacher A; Ladenstein R
Structural investigation on recombinant riboflavin synthase from E. coli.
Biochemical Society transactions 1996;24(1):34S.
1995: Nar H; Huber R; Auerbach G; Fischer M; Hösl C; Ritz H; Bracher A; Meining W; Eberhardt S; Bacher A
Active site topology and reaction mechanism of GTP cyclohydrolase I.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12120-5.
1995: Meining W; Bacher A; Bachmann L; Schmid C; Weinkauf S; Huber R; Nar H
Elucidation of crystal packing by X-ray diffraction and freeze-etching electron microscopy. Studies on GTP cyclohydrolase I of Escherichia coli.
Journal of molecular biology 1995;253(1):208-18.
1995: Ritsert K; Huber R; Turk D; Ladenstein R; Schmidt-Bäse K; Bacher A
Studies on the lumazine synthase/riboflavin synthase complex of Bacillus subtilis: crystal structure analysis of reconstituted, icosahedral beta-subunit capsids with bound substrate analogue inhibitor at 2.4 A resolution.
Journal of molecular biology 1995;253(1):151-67.
1995: Kis K; Bacher A
Substrate channeling in the lumazine synthase/riboflavin synthase complex of Bacillus subtilis.
The Journal of biological chemistry 1995;270(28):16788-95.
1995: Nar H; Huber R; Meining W; Schmid C; Weinkauf S; Bacher A
Atomic structure of GTP cyclohydrolase I.
Structure (London, England : 1993) 1995;3(5):459-66.
1995: Kis K; Volk R; Bacher A
Biosynthesis of riboflavin. Studies on the reaction mechanism of 6,7-dimethyl-8-ribityllumazine synthase.
Biochemistry 1995;34(9):2883-92.
1994: Gütlich M; Ziegler I; Witter K; Hemmens B; Hültner L; McDonald J D; Werner T; Rödl W; Bacher A
Molecular characterization of HPH-1: a mouse mutant deficient in GTP cyclohydrolase I activity.
Biochemical and biophysical research communications 1994;203(3):1675-81.
1994: Gütlich M; Jaeger E; Rücknagel K P; Werner T; Rödl W; Ziegler I; Bacher A
Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme.
The Biochemical journal 1994;302 ( Pt 1)():215-21.
1994: Ladenstein R; Ritsert K; Huber R; Richter G; Bacher A
The lumazine synthase/riboflavin synthase complex of Bacillus subtilis. X-ray structure analysis of hollow reconstituted beta-subunit capsids.
European journal of biochemistry / FEBS 1994;223(3):1007-17.
1994: Scheuring J; Lee J; Cushman M; Patel H; Patrick D A; Bacher A
(Trifluoromethyl)lumazine derivatives as 19F NMR probes for lumazine protein.
Biochemistry 1994;33(24):7634-40.
1993: Eisenreich W; Strauss G; Werz U; Fuchs G; Bacher A
Retrobiosynthetic analysis of carbon fixation in the phototrophic eubacterium Chloroflexus aurantiacus.
European journal of biochemistry / FEBS 1993;215(3):619-32.
1993: Richter G; Ritz H; Katzenmeier G; Volk R; Kohnle A; Lottspeich F; Allendorf D; Bacher A
Biosynthesis of riboflavin: cloning, sequencing, mapping, and expression of the gene coding for GTP cyclohydrolase II in Escherichia coli.
Journal of bacteriology 1993;175(13):4045-51.
1993: Ritz H; Keller G; Richter G; Katzenmeier G; Bacher A
Location of the gene coding for GTP cyclohydrolase I on the physical map of Escherichia coli.
Journal of bacteriology 1993;175(5):1553.
1993: Maier J; Schott K; Werner T; Bacher A; Ziegler I
Detection of a novel sepiapterin reductase mRNA: assay of mRNA in various cells and tissues of various species.
Experimental cell research 1993;204(2):217-22.
1993: Koch J; Eisenreich W; Bacher A; Fuchs G
Products of enzymatic reduction of benzoyl-CoA, a key reaction in anaerobic aromatic metabolism.
European journal of biochemistry / FEBS 1993;211(3):649-61.
1993: Maier J; Schott K; Werner T; Bacher A; Ziegler I
Northern blot analysis of sepiapterin reductase mRNA in mammalian cell lines and tissues.
Advances in experimental medicine and biology 1993;338():195-8.
1993: Gütlich M; Schott K; Werner T; Bacher A; Ziegler I
Detection and quantification of GTP cyclohydrolase I mRNA.
Advances in experimental medicine and biology 1993;338():167-70.
1992: Gütlich M; Schott K; Werner T; Bacher A; Ziegler I
Species and tissue specificity of mammalian GTP cyclohydrolase I messenger RNA.
Biochimica et biophysica acta 1992;1171(2):133-40.
1992: Schmid C; Ladenstein R; Luecke H; Huber R; Bacher A
Crystallization and preliminary crystallographic characterization of GTP cyclohydrolase I from Escherichia coli.
Journal of molecular biology 1992;226(4):1279-81.
1992: Bacher A; Weinkauf S; Bachmann L; Ritsert K; Baumeister W; Huber R; Ladenstein R
Electron microscopy of decorated crystals for the determination of crystallographic rotation and translation parameters in large protein complexes.
Journal of molecular biology 1992;225(4):1065-73.
1992: Richter G; Volk R; Krieger C; Lahm H W; Röthlisberger U; Bacher A
Biosynthesis of riboflavin: cloning, sequencing, and expression of the gene coding for 3,4-dihydroxy-2-butanone 4-phosphate synthase of Escherichia coli.
Journal of bacteriology 1992;174(12):4050-6.
1992: Reuke B; Korn S; Eisenreich W; Bacher A
Biosynthetic precursors of deazaflavins.
Journal of bacteriology 1992;174(12):4042-9.
1992: Bacher A; Griebl K; Mackamul S; Mitreiter R; Mückter H; Ben-Shaul Y
Protease inhibitors suppress the formation of tight junctions in gastrointestinal cell lines.
Experimental cell research 1992;200(1):97-104.
1992: Keller G; Ben-Shaul Y; Bacher A
Influence of metabolic inhibitors on the degradation of tight junctions in HT29 cells.
Experimental cell research 1992;200(1):16-25.
1992: Strauss G; Eisenreich W; Bacher A; Fuchs G
13C-NMR study of autotrophic CO2 fixation pathways in the sulfur-reducing Archaebacterium Thermoproteus neutrophilus and in the phototrophic Eubacterium Chloroflexus aurantiacus.
European journal of biochemistry / FEBS 1992;205(2):853-66.
1991: Eisenreich W; Bacher A
Biosynthesis of 5-hydroxybenzimidazolylcobamid (factor III) in Methanobacterium thermoautotrophicum.
The Journal of biological chemistry 1991;266(35):23840-9.
1991: Volk R; Bacher A
Biosynthesis of riboflavin. Studies on the mechanism of L-3,4-dihydroxy-2-butanone 4-phosphate synthase.
The Journal of biological chemistry 1991;266(31):20610-8.
1991: Katzenmeier G; Schmid C; Kellermann J; Lottspeich F; Bacher A
Biosynthesis of tetrahydrofolate. Sequence of GTP cyclohydrolase I from Escherichia coli.
Biological chemistry Hoppe-Seyler 1991;372(11):991-7.
1991: Weinkauf S; Bacher A; Baumeister W; Ladenstein R; Huber R; Bachmann L
Correlation of metal decoration and topochemistry on protein surfaces.
Journal of molecular biology 1991;221(2):637-45.
1991: Eisenreich W; Schwarzkopf B; Bacher A
Biosynthesis of nucleotides, flavins, and deazaflavins in Methanobacterium thermoautotrophicum.
The Journal of biological chemistry 1991;266(15):9622-31.
1990: Volk R; Bacher A
Studies on the 4-carbon precursor in the biosynthesis of riboflavin. Purification and properties of L-3,4-dihydroxy-2-butanone-4-phosphate synthase.
The Journal of biological chemistry 1990;265(32):19479-85.
1990: Ziegler I; Schott K; Lübbert M; Herrmann F; Schwuléra U; Bacher A
Control of tetrahydrobiopterin synthesis in T lymphocytes by synergistic action of interferon-gamma and interleukin-2.
The Journal of biological chemistry 1990;265(28):17026-30.
1990: Kerler F; Ziegler I; Schmid C; Bacher A
Synthesis of tetrahydrobiopterin in Friend erythroleukemia cells and its modulator effect on cell proliferation.
Experimental cell research 1990;189(2):151-6.
1990: Schott K; Ladenstein R; König A; Bacher A
The lumazine synthase-riboflavin synthase complex of Bacillus subtilis. Crystallization of reconstituted icosahedral beta-subunit capsids.
The Journal of biological chemistry 1990;265(21):12686-9.
1990: Schott K; Kellermann J; Lottspeich F; Bacher A
Riboflavin synthases of Bacillus subtilis. Purification and amino acid sequence of the alpha subunit.
The Journal of biological chemistry 1990;265(8):4204-9.
1990: Kerler F; Hültner L; Ziegler I; Katzenmaier G; Bacher A
Analysis of the tetrahydrobiopterin synthesizing system during maturation of murine reticulocytes.
Journal of cellular physiology 1990;142(2):268-71.
1990: Katzenmeier G; Schmid C; Bacher A
Cloning and expression of the putative gene coding for GTP cyclohydrolase I from Escherichia coli.
FEMS microbiology letters 1990;54(1-3):231-4.
1989: Schäfer S; Götz M; Eisenreich W; Bacher A; Fuchs G
13C-NMR study of autotrophic CO2 fixation in Thermoproteus neutrophilus.
European journal of biochemistry / FEBS 1989;184(1):151-6.
1989: Kerler F; Ziegler I; Schwarzkopf B; Bacher A
Regulation of tetrahydrobiopterin synthesis during lectin stimulation of human peripheral blood lymphocytes.
FEBS letters 1989;250(2):622-4.
1989: Bachmann L; Weinkauf S; Baumeister W; Wildhaber I; Bacher A
Electron microscopy of subnanometer surface features on metal-decorated protein crystals.
Journal of molecular biology 1989;207(3):575-84.
1989: Kerler F; Schwarzkopf B; Katzenmaier G; Le Van Q; Schmid C; Ziegler I; Bacher A
Biosynthesis of tetrahydrobiopterin: a sensitive assay of 6-pyruvoyltetrahydropterin synthase using [2'-3H]dihydroneopterin 3'-triphosphate as substrate.
Biochimica et biophysica acta 1989;990(1):15-7.
1988: Ladenstein R; Schneider M; Huber R; Bartunik H D; Wilson K; Schott K; Bacher A
Heavy riboflavin synthase from Bacillus subtilis. Crystal structure analysis of the icosahedral beta 60 capsid at 3.3 A resolution.
Journal of molecular biology 1988;203(4):1045-70.
1988: Faff O; Mitreiter R; Mückter H; Ben-Shaul Y; Bacher A
Rapid formation of tight junctions in HT 29 human adenocarcinoma cells by hypertonic salt solutions.
Experimental cell research 1988;177(1):60-72.
1988: Le Van Q; Katzenmeier G; Schwarzkopf B; Schmid C; Bacher A
Biosynthesis of biopterin. Studies on the mechanism of 6-pyruvoyltetrahydropteridine synthase.
Biochemical and biophysical research communications 1988;151(1):512-7.
1987: Faff O; Cohen E; Bacher A; Ben-Shaul Y
Proteinase-induced formation of focal tight junctions in HT 29 adenocarcinoma cells does not require extracellular calcium.
Biochimica et biophysica acta 1987;905(1):48-56.
1987: Mückter H; Ben-Shaul Y; Bacher A
ATP requirement for induced tight junction formation in HT 29 adenocarcinoma cells.
European journal of cell biology 1987;44(2):258-64.
1987: Ladenstein R; Bacher A; Huber R
Some observations of a correlation between the symmetry of large heavy-atom complexes and their binding sites on proteins.
Journal of molecular biology 1987;195(3):751-3.
1986: Ben-Shaul Y; Cohen E; Faff O; Mückter H; Bacher A
Assembly of tight junctions in cultured human epithelial cells.
Progress in clinical and biological research 1986;217A():349-52.
1985: Cohen E; Talmon A; Faff O; Bacher A; Ben-Shaul Y
Formation of tight junctions in epithelial cells. I. Induction by proteases in a human colon carcinoma cell line.
Experimental cell research 1985;156(1):103-16.
1984: Talmon A; Cohen E; Bacher A; Ben-Shaul Y
Separation of induction and expression of tight junction formation mediated by proteinases.
Biochimica et biophysica acta 1984;769(2):505-7.

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