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Barbara Kahn

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Yossi Dagon; Elizabeth Hur; Kerry Wellenstein; Bin Zheng; Lewis C Cantley; Barbara B Kahn
p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.
Julie Norseen; David A Phillips; Ulf Smith; Anny Usheva; Mark M Yore; Pratik Aryal; Roger J Davis; Ann Hammarstedt; Tetsuya Hosooka; Shashi Kant; Urban A Kiernan; Bettina J Kraus; Hiroshi Maruyama; Barbara B Kahn
Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism.
Mark A Herman; Nada A Abumrad; Matthias Blüher; Samuel Klein; Odile D Peroni; Michael R Schön; Jorge Villoria; Barbara B Kahn
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.

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All Publications

2012: Yossi Dagon; Elizabeth Hur; Kerry Wellenstein; Bin Zheng; Lewis C Cantley; Barbara B Kahn
p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.
Cell metabolism 2012;16(1):104-12.
2012: Julie Norseen; David A Phillips; Ulf Smith; Anny Usheva; Mark M Yore; Pratik Aryal; Roger J Davis; Ann Hammarstedt; Tetsuya Hosooka; Shashi Kant; Urban A Kiernan; Bettina J Kraus; Hiroshi Maruyama; Barbara B Kahn
Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism.
Molecular and cellular biology 2012;32(10):2010-9.
2012: Mark A Herman; Nada A Abumrad; Matthias Blüher; Samuel Klein; Odile D Peroni; Michael R Schön; Jorge Villoria; Barbara B Kahn
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.
Nature 2012;484(7394):333-8.
2012: Ann Hammarstedt; Timothy E Graham; Barbara B Kahn
Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells.
Diabetology & metabolic syndrome 2012;4(1):42.
2012: Junji Kawashima; Odile D Peroni; Youki Tsuji; Thierry Alquier; Barbara B Kahn
Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia.
PloS one 2012;7(5):e36335.
2012: Carl Owen; Andy Welch; Abdelali Agouni; Kendra K Bence; Alicja Czopek; Olga Göransson; Louise Grant; Robert Judson; Barbara B Kahn; Emma K Lees; George D Mcilroy; Nimesh Mody; Benjamin G Neel; Mirela Delibegović
Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.
PloS one 2012;7(2):e32700.
2011: Kim Loh; Benjamin G Neel; Alexander Reichenbach; Stephanie Simonds; Natalie A Sims; Florian Wiede; Sheng Zhang; Xinmei Zhang; Zhong-Yin Zhang; Zane B Andrews; Kendra K Bence; Dana Briggs; Michael Alexander cowley; Pablo J Enriori; Atsushi Fukushima; Sandra Galic; Christine Hauser; Barbara B Kahn; Tony Tiganis
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.
Cell metabolism 2011;14(5):684-99.
2011: THOMAS CHACKO PULINILKUNNIL; Huamei He; Dong Kong; Kenji Asakura; Odile D Peroni; Anna Lee; Barbara B Kahn
Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo.
The Journal of biological chemistry 2011;286(11):8798-809.
2010: Barbara B Kahn; Timothy E McGraw
Rosiglitazone, PPARγ, and type 2 diabetes.
The New England journal of medicine 2010;363(27):2667-9.
2010: Mark A Herman; Pengxiang She; Odile D Peroni; Christopher J Lynch; Barbara B Kahn
Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels.
The Journal of biological chemistry 2010;285(15):11348-56.
2010: Daniel Kraus; Mark A Herman; Barbara B Kahn
Leveraging leptin for type I diabetes?
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):4793-4.
2009: Frederic Preitner; Nimesh Mody; Timothy E Graham; Odile D Peroni; Barbara B Kahn
Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis.
American journal of physiology. Endocrinology and metabolism 2009;297(6):E1420-9.
2009: Jennifer W Hill; Yong Xu; Frederic Preitner; Makota Fukuda; You-Ree Cho; Ji Luo; Nina Balthasar; Roberto Coppari; Lewis C Cantley; Barbara B Kahn; Jean J Zhao; Joel K Elmquist
Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.
Endocrinology 2009;150(11):4874-82.
2009: Jian Liu; Adeline Divoux; Jiusong Sun; Jie Zhang; Karine Clément; Jonathan N Glickman; Galina K Sukhova; Paul J Wolters; Juan Du; Cem Z Gorgun; Alessandro Doria; Peter Libby; Richard S Blumberg; Barbara B Kahn; Gökhan S Hotamisligil; Guo-Ping Shi
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.
Nature medicine 2009;15(8):940-5.
2009: Bingzhong Xue; THOMAS CHACKO PULINILKUNNIL; Incoronata Murano; Kendra K Bence; Huamei He; Yasuhiko Minokoshi; Kenji Asakura; Anna Lee; Fawaz Haj; Noboru Furukawa; Karyn J Catalano; Mirela Delibegovic; James A Balschi; Saverio Cinti; Benjamin G Neel; Barbara B Kahn
Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.
Molecular and cellular biology 2009;29(16):4563-73.
2009: Mirela Delibegovic; Derek Zimmer; Caitlin Kauffman; Kimberly Rak; Eun-Gyoung Hong; You-Ree Cho; Jason K Kim; Barbara B Kahn; Benjamin G Neel; Kendra K Bence
Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress.
Diabetes 2009;58(3):590-9.
2008: Janice M Zabolotny; Young-Bum Kim; Laura A Welsh; Erin E Kershaw; Benjamin G Neel; Barbara B Kahn
Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.
The Journal of biological chemistry 2008;283(21):14230-41.
2008: Ann Hammarstedt; J Pihlajamäki; Timothy E Graham; S Kainulainen; Barbara B Kahn; Markku Laakso; Ulf Smith
High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects.
Journal of internal medicine 2008;263(4):440-9.
2008: Nimesh Mody; Timothy E Graham; Yuki Tsuji; Qin Yang; Barbara B Kahn
Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice.
American journal of physiology. Endocrinology and metabolism 2008;294(4):E785-93.
2007: Peter Kovacs; Michaela Geyer; Janin Berndt; Nora Klöting; Timothy E Graham; Yvonne Böttcher; Beate Enigk; Anke Tönjes; Dorit Schleinitz; Michael R Schön; Barbara B Kahn; Matthias Blüher; Michael Stumvoll
Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression.
Diabetes 2007;56(12):3095-100.
2007: Mirela Delibegovic; Kendra K Bence; Nimesh Mody; Eun-Gyoung Hong; Hwi Jin Ko; Jason K Kim; Barbara B Kahn; Benjamin G Neel
Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.
Molecular and cellular biology 2007;27(21):7727-34.
2007: Qing-Wu Yan; Qin Yang; Nimesh Mody; Timothy E Graham; Chung-Hsin Hsu; Zhao Xu; Nicholas E Houstis; Barbara B Kahn; Evan D Rosen
The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance.
Diabetes 2007;56(10):2533-40.
2007: Bingzhong Xue; Young-Bum Kim; Anna Lee; Elena Toschi; Susan Bonner-Weir; C Ronald Kahn; Benjamin G Neel; Barbara B Kahn
Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
The Journal of biological chemistry 2007;282(33):23829-40.
2007: Min Yang; Yaou Zhang; Jiehong Pan; Jiusong Sun; Jian Liu; Peter Libby; Galina K Sukhova; Alessandro Doria; Nobuhiko Katunuma; Odile D Peroni; Michèle Guerre-Millo; Barbara B Kahn; Karine Clement; Guo-Ping Shi
Cathepsin L activity controls adipogenesis and glucose tolerance.
Nature cell biology 2007;9(8):970-7.
2007: Kitt Falk Petersen; Sylvie Dufour; David B Savage; Stefan Bilz; Gina Solomon; Shin Yonemitsu; Gary W Cline; Douglas Befroy; Laura Zemany; Barbara B Kahn; Xenophon Papademetris; Douglas L Rothman; Gerald I Shulman
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12587-94.
2007: Nora Klöting; Timothy E Graham; Janin Berndt; Susan Kralisch; Peter Kovacs; Christopher J Wason; Mathias Fasshauer; Michael R Schön; Michael Stumvoll; Matthias Blüher; Barbara B Kahn
Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass.
Cell metabolism 2007;6(1):79-87.
2007: Adam R Kennedy; Pavlos Pissios; Hasan H Otu; Russell Roberson; Bingzhong Xue; Kenji Asakura; Noburu Furukawa; Frank E Marino; Fen-Fen Liu; Barbara B Kahn; Towia Libermann; Eleftheria Maratos-Flier
A high-fat, ketogenic diet induces a unique metabolic state in mice.
American journal of physiology. Endocrinology and metabolism 2007;292(6):E1724-39.
2007: Susan Gray; Baiqiu Wang; Yvette Orihuela; Eun-Gyoung Hong; Sudeshna Fisch; Saptarsi Haldar; Gary W Cline; Jason K Kim; Odile D Peroni; Barbara B Kahn; Mukesh K Jain
Regulation of gluconeogenesis by Krüppel-like factor 15.
Cell metabolism 2007;5(4):305-12.
2007: Timothy E Graham; Christopher J Wason; Matthias Blüher; Barbara B Kahn
Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects.
Diabetologia 2007;50(4):814-23.
2007: Thierry Alquier; Junji Kawashima; Youki Tsuji; Barbara B Kahn
Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia.
Endocrinology 2007;148(3):1367-75.
2006: Kendra K Bence; Mirela Delibegovic; Bingzhong Xue; Cem Z Gorgun; Gökhan S Hotamisligil; Benjamin G Neel; Barbara B Kahn
Neuronal PTP1B regulates body weight, adiposity and leptin action.
Nature medicine 2006;12(8):917-24.
2006: Tonya L Martin; Thierry Alquier; Kenji Asakura; Noboru Furukawa; Frederic Preitner; Barbara B Kahn
Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle.
The Journal of biological chemistry 2006;281(28):18933-41.
2006: Mark A Herman; Barbara B Kahn
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony.
The Journal of clinical investigation 2006;116(7):1767-75.
2006: Bingzhong Xue; Barbara B Kahn
AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues.
The Journal of physiology 2006;574(Pt 1):73-83.
2006: Timothy E Graham; Qin Yang; Matthias Blüher; Ann Hammarstedt; Theodore P Ciaraldi; Robert R Henry; Christopher J Wason; Andreas Oberbach; Per-Anders Jansson; Ulf Smith; Barbara B Kahn
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.
The New England journal of medicine 2006;354(24):2552-63.
2005: Young-Bum Kim; Odile D Peroni; william aschenbach; Yasuhiko Minokoshi; Ko Kotani; Ariel Zisman; C Ronald Kahn; Laurie J Goodyear; Barbara B Kahn
Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism.
Molecular and cellular biology 2005;25(21):9713-23.
2005: Eugenia Carvalho; Ko Kotani; Odile D Peroni; Barbara B Kahn
Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle.
American journal of physiology. Endocrinology and metabolism 2005;289(4):E551-61.
2005: Noboru Furukawa; Pat Ongusaha; Wan Jin Jahng; Kazushi Araki; Cheol Soo Choi; Hyo-Jeong Kim; Yong Hee Lee; Kozo Kaibuchi; Barbara B Kahn; Hiroaki Masuzaki; Jason K Kim; Sam W Lee; Young-Bum Kim
Role of Rho-kinase in regulation of insulin action and glucose homeostasis.
Cell metabolism 2005;2(2):119-29.
2005: Qin Yang; Timothy E Graham; Nimesh Mody; Frederic Preitner; Odile D Peroni; Janice M Zabolotny; Ko Kotani; Loredana Quadro; Barbara B Kahn
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.
Nature 2005;436(7049):356-62.
2005: Julie R Jones; Cordelia Barrick; Kyoung-Ah Kim; Jill Lindner; bertrand blondeau; Yuka Fujimoto; Masakazu Shiota; Robert A Kesterson; Barbara B Kahn; Mark Magnuson
Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):6207-12.
2005: Fawaz G Haj; Janice M Zabolotny; Young-Bum Kim; Barbara B Kahn; Benjamin G Neel
Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice.
The Journal of biological chemistry 2005;280(15):15038-46.
2005: Kazuhisa Maeda; Haiming Cao; Keita Kono; Cem Z Gorgun; Masato Furuhashi; Teo Uysal; Qiong Cao; Genichi Atsumi; Harry Malone; Bala Krishnan; Yasuhiko Minokoshi; Barbara B Kahn; Rex A Parker; Gökhan S Hotamisligil
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.
Cell metabolism 2005;1(2):107-19.
2005: Barbara B Kahn; Thierry Alquier; David Carling; D Grahame Hardie
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
Cell metabolism 2005;1(1):15-25.
2005: Sandra Galic; Christine Hauser; Barbara B Kahn; Fawaz G Haj; Benjamin G Neel; Nicholas K Tonks; Tony Tiganis
Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.
Molecular and cellular biology 2005;25(2):819-29.
2004: Ko Kotani; Odile D Peroni; Yasuhiko Minokoshi; Olivier Boss; Barbara B Kahn
GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.
The Journal of clinical investigation 2004;114(11):1666-75.
2004: Thierry Alquier; Barbara B Kahn
Peripheral signals set the tone for central regulation of metabolism.
Endocrinology 2004;145(9):4022-4.
2004: Matthias Blüher; Mary-Elizabeth Patti; Stephane Gesta; Barbara B Kahn; C Ronald Kahn
Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression.
The Journal of biological chemistry 2004;279(30):31891-901.
2004: Janice M Zabolotny; Fawaz G Haj; Young-Bum Kim; Hyo-Jeong Kim; Gerald I Shulman; Jason K Kim; Benjamin G Neel; Barbara B Kahn
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.
The Journal of biological chemistry 2004;279(23):24844-51.
2004: Katja A Lamia; Odile D Peroni; Young-Bum Kim; Lucia E Rameh; Barbara B Kahn; Lewis C Cantley
Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.
Molecular and cellular biology 2004;24(11):5080-7.
2004: Eugenia Carvalho; Sarah E Schellhorn; Janice M Zabolotny; Sally Martin; Effie Tozzo; Odile D Peroni; Karen L Houseknecht; Adrian Mundt; David E James; Barbara B Kahn
GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase.
The Journal of biological chemistry 2004;279(20):21598-605.
2004: Yasuhiko Minokoshi; Thierry Alquier; Noboru Furukawa; Yong-Bum Kim; Anna Lee; Bingzhong Xue; James Mu; Fabienne Foufelle; Pascal Ferré; Morris J Birnbaum; Bettina J Stuck; Barbara B Kahn
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.
Nature 2004;428(6982):569-74.
2004: Christian Bjørbaek; Barbara B Kahn
Leptin signaling in the central nervous system and the periphery.
Recent progress in hormone research 2004;59():305-31.
2004: Jake A Kushner; Fawaz G Haj; Lori D Klaman; Matthew A Dow; Barbara B Kahn; Benjamin G Neel; Morris F White
Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.
Diabetes 2004;53(1):61-6.
2003: Yasuhiko Minokoshi; C Ronald Kahn; Barbara B Kahn
Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis.
The Journal of biological chemistry 2003;278(36):33609-12.
2003: Young-Bum Kim; Ko Kotani; Theodore P Ciaraldi; Robert R Henry; Barbara B Kahn
Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction.
Diabetes 2003;52(8):1935-42.
2003: Matthias Blüher; Barbara B Kahn; C Ronald Kahn
Extended longevity in mice lacking the insulin receptor in adipose tissue.
Science (New York, N.Y.) 2003;299(5606):572-4.
2002: Young-Bum Kim; Gerald I Shulman; Barbara B Kahn
Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3.
The Journal of biological chemistry 2002;277(36):32915-22.
2002: Cheol Soo Choi; Young-Bum Kim; Felix N Lee; Janice M Zabolotny; Barbara B Kahn; Jang H Youn
Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling.
American journal of physiology. Endocrinology and metabolism 2002;283(2):E233-40.
2002: Matthias Blüher; M Dodson Michael; Odile D Peroni; Kohjiro Ueki; Nathan Carter; Barbara B Kahn; C Ronald Kahn
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance.
Developmental cell 2002;3(1):25-38.
2002: Janice M Zabolotny; Kendra K Bence-Hanulec; Alain Stricker-Krongrad; Fawaz G Haj; Yongping Wang; Yasuhiko Minokoshi; Young-Bum Kim; Joel K Elmquist; Louis A Tartaglia; Barbara B Kahn; Benjamin G Neel
PTP1B regulates leptin signal transduction in vivo.
Developmental cell 2002;2(4):489-95.
2002: Young-Bum Kim; Theodore P Ciaraldi; Alice Kong; Dennis Kim; Neelima Chu; Pharis Mohideen; Sunder Mudaliar; Robert R Henry; Barbara B Kahn
Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects.
Diabetes 2002;51(2):443-8.
2002: Yasuhiko Minokoshi; Young-Bum Kim; Odile D Peroni; Lee G D Fryer; Corinna Müller; David Carling; Barbara B Kahn
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase.
Nature 2002;415(6869):339-43.
2001: Jason K Kim; Ariel Zisman; Jonathan J Fillmore; Odile D Peroni; Ko Kotani; Pascale Perret; Haihong Zong; Jianying Dong; C Ronald Kahn; Barbara B Kahn; Gerald I Shulman
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4.
The Journal of clinical investigation 2001;108(1):153-60.
2001: Janice M Zabolotny; Young-Bum Kim; Odile D Peroni; Jason K Kim; Michael Aleksander Pani; Olivier Boss; Lori D Klaman; S Kamatkar; Gerald I Shulman; Barbara B Kahn; Benjamin G Neel
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5187-92.
2001: E Dale Abel; Odile D Peroni; J K Kim; Y B Kim; Olivier Boss; E Hadro; T Minnemann; Gerald I Shulman; Barbara B Kahn
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver.
Nature 2001;409(6821):729-33.
2000: Barbara B Kahn; Jeffrey S Flier
Obesity and insulin resistance.
The Journal of clinical investigation 2000;106(4):473-81.
2000: Ariel Zisman; Odile D Peroni; E Dale Abel; M Dodson Michael; Franck Mauvais-Jarvis; Bradford B Lowell; J F Wojtaszewski; Michael F Hirshman; A Virkamaki; Laurie J Goodyear; C Ronald Kahn; Barbara B Kahn
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.
Nature medicine 2000;6(8):924-8.
2000: Lori D Klaman; Olivier Boss; Odile D Peroni; Jason K Kim; J L Martino; Janice M Zabolotny; N Moghal; M Lubkin; Young-Bum Kim; A H Sharpe; Alain Stricker-Krongrad; Gerald I Shulman; Benjamin G Neel; Barbara B Kahn
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.
Molecular and cellular biology 2000;20(15):5479-89.
2000: Y B Kim; S Uotani; D D Pierroz; Jeffrey S Flier; Barbara B Kahn
In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin.
Endocrinology 2000;141(7):2328-39.
2000: C L Venable; EU Frevert; Young-Bum Kim; B M Fischer; S Kamatkar; Benjamin G Neel; Barbara B Kahn
Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation.
The Journal of biological chemistry 2000;275(24):18318-26.
2000: S K Rasmussen; L Hansen; EU Frevert; P T Cohen; Barbara B Kahn; Oluf Pedersen
Adenovirus-mediated expression of a naturally occurring Asp905Tyr variant of the glycogen-associated regulatory subunit of protein phosphatase-1 in L6 myotubes.
Diabetologia 2000;43(6):718-22.
2000: Jason K Kim; M Dodson Michael; Stephen Previs; Odile D Peroni; Franck Mauvais-Jarvis; Susanne Neschen; Barbara B Kahn; C Ronald Kahn; Gerald I Shulman
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle.
The Journal of clinical investigation 2000;105(12):1791-7.
2000: Y B Kim; Odile D Peroni; T F Franke; Barbara B Kahn
Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats.
Diabetes 2000;49(5):847-56.
2000: Z Xie; H Li; L Liu; Barbara B Kahn; S M Najjar; W Shah
Metabolic regulation of Na(+)/P(i)-cotransporter-1 gene expression in H4IIE cells.
American journal of physiology. Endocrinology and metabolism 2000;278(4):E648-55.
1999: Peter R Shepherd; Barbara B Kahn
Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus.
The New England journal of medicine 1999;341(4):248-57.
1999: E S Oh; Haihua Gu; T M Saxton; John Francis Timms; S Hausdorff; EU Frevert; Barbara B Kahn; T Pawson; Benjamin G Neel; Sheila M Thomas
Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.
Molecular and cellular biology 1999;19(4):3205-15.
1999: Brian K Law; Peter Nørgaard; Luigi Gnudi; Barbara B Kahn; H S Poulson; Harold L Moses
Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway.
The Journal of biological chemistry 1999;274(8):4743-8.
1998: EU Frevert; C Bjørbaek; C L Venable; Susanna R Keller; Barbara B Kahn
Targeting of constitutively active phosphoinositide 3-kinase to GLUT4-containing vesicles in 3T3-L1 adipocytes.
The Journal of biological chemistry 1998;273(39):25480-7.
1998: Peter Kometiani; J Li; Luigi Gnudi; Barbara B Kahn; Amir Askari; Zijian Xie
Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases.
The Journal of biological chemistry 1998;273(24):15249-56.
1998: Barbara B Kahn
Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance.
Cell 1998;92(5):593-6.
1998: Calum Sutherland; Mary Waltner-Law; Luigi Gnudi; Barbara B Kahn; Daryl K Granner
Activation of the ras mitogen-activated protein kinase-ribosomal protein kinase pathway is not required for the repression of phosphoenolpyruvate carboxykinase gene transcription by insulin.
The Journal of biological chemistry 1998;273(6):3198-204.
1998: Juleen R Zierath; EU Frevert; Jeffrey W Ryder; Per-Olof Berggren; Barbara B Kahn
Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes.
Diabetes 1998;47(1):1-4.
1997: E Tozzo; Luigi Gnudi; Barbara B Kahn
Amelioration of insulin resistance in streptozotocin diabetic mice by transgenic overexpression of GLUT4 driven by an adipose-specific promoter.
Endocrinology 1997;138(4):1604-11.
1997: Juleen R Zierath; Karen L Houseknecht; Luigi Gnudi; Barbara B Kahn
High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect.
Diabetes 1997;46(2):215-23.
1997: Luigi Gnudi; EU Frevert; Karen L Houseknecht; P Erhardt; Barbara B Kahn
Adenovirus-mediated gene transfer of dominant negative ras(asn17) in 3T3L1 adipocytes does not alter insulin-stimulated P13-kinase activity or glucose transport.
Molecular endocrinology (Baltimore, Md.) 1997;11(1):67-76.
1997: EU Frevert; Barbara B Kahn
Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes.
Molecular and cellular biology 1997;17(1):190-8.
1996: Barbara B Kahn
Lilly lecture 1995. Glucose transport: pivotal step in insulin action.
Diabetes 1996;45(11):1644-54.
1996: Karen L Houseknecht; C S Mantzoros; Regina Kuliawat; E Hadro; Jeffrey S Flier; Barbara B Kahn
Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity.
Diabetes 1996;45(11):1638-43.
1996: EU Frevert; Barbara B Kahn
Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states.
The Biochemical journal 1996;316 ( Pt 3)():865-71.
1996: Karen L Houseknecht; A X Zhu; Luigi Gnudi; A Hamann; Juleen R Zierath; E Tozzo; Jeffrey S Flier; Barbara B Kahn
Overexpression of Ha-ras selectively in adipose tissue of transgenic mice. Evidence for enhanced sensitivity to insulin.
The Journal of biological chemistry 1996;271(19):11347-55.
1996: E Tozzo; Barbara B Kahn; P F Pilch; K V Kandror
Glut4 is targeted to specific vesicles in adipocytes of transgenic mice overexpressing Glut4 selectively in adipose tissue.
The Journal of biological chemistry 1996;271(18):10490-4.
1996: Luigi Gnudi; Dalan R Jensen; E Tozzo; Robert H Eckel; Barbara B Kahn
Adipose-specific overexpression of GLUT-4 in transgenic mice alters lipoprotein lipase activity.
The American journal of physiology 1996;270(4 Pt 2):R785-92.
1996: Luigi Gnudi; Peter R Shepherd; Barbara B Kahn
Over-expression of GLUT4 selectively in adipose tissue in transgenic mice: implications for nutrient partitioning.
The Proceedings of the Nutrition Society 1996;55(1B):191-9.
1996: R A Gabbay; Calum Sutherland; Luigi Gnudi; Barbara B Kahn; R M O'Brien; Daryl K Granner; Jeffrey S Flier
Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway.
The Journal of biological chemistry 1996;271(4):1890-7.
1995: VS Susulic; RC Frederich; J Lawitts; E Tozzo; Barbara B Kahn; Mary-Ellen Harper; Jean Himms-Hagen; Jeffrey S Flier; Bradford B Lowell
Targeted disruption of the beta 3-adrenergic receptor gene.
The Journal of biological chemistry 1995;270(49):29483-92.
1995: Juleen R Zierath; L A Nolte; E Wahlström; Dana Galuska; Peter R Shepherd; Barbara B Kahn; Harriet Wallberg-Henriksson
Carrier-mediated fructose uptake significantly contributes to carbohydrate metabolism in human skeletal muscle.
The Biochemical journal 1995;311 ( Pt 2)():517-21.
1995: RC Frederich; B Löllmann; A Hamann; A Napolitano-Rosen; Barbara B Kahn; Bradford B Lowell; Jeffrey S Flier
Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.
The Journal of clinical investigation 1995;96(3):1658-63.
1995: E Tozzo; Peter R Shepherd; Luigi Gnudi; Barbara B Kahn
Transgenic GLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acid synthesis.
The American journal of physiology 1995;268(5 Pt 1):E956-64.
1995: Luigi Gnudi; E Tozzo; Peter R Shepherd; J L Bliss; Barbara B Kahn
High level overexpression of glucose transporter-4 driven by an adipose-specific promoter is maintained in transgenic mice on a high fat diet, but does not prevent impaired glucose tolerance.
Endocrinology 1995;136(3):995-1002.
1995: Henrik Vestergaard; J E Weinreb; A S Rosen; C Bjørbaek; Lars Hansen; Oluf Pedersen; Barbara B Kahn
Sulfonylurea therapy improves glucose disposal without changing skeletal muscle GLUT4 levels in noninsulin-dependent diabetes mellitus subjects: a longitudinal study.
The Journal of clinical endocrinology and metabolism 1995;80(1):270-5.
1993: P H Andersen; S Lund; O Schmitz; S Junker; Barbara B Kahn; O Pedersen
Increased insulin-stimulated glucose uptake in athletes: the importance of GLUT4 mRNA, GLUT4 protein and fibre type composition of skeletal muscle.
Acta physiologica Scandinavica 1993;149(4):393-404.
1993: Peter R Shepherd; Luigi Gnudi; E Tozzo; H Yang; F Leach; Barbara B Kahn
Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.
The Journal of biological chemistry 1993;268(30):22243-6.
1993: P H Andersen; Henrik Vestergaard; S Lund; P Vedel; S Junker; Barbara B Kahn; O Pedersen
The effect of intensive insulin therapy on the insulin-regulatable glucose transporter (GLUT4) expression in skeletal muscle in type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 1993;10(8):699-706.
1993: P H Andersen; S Lund; Henrik Vestergaard; S Junker; Barbara B Kahn; O Pedersen
Expression of the major insulin regulatable glucose transporter (GLUT4) in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion.
The Journal of clinical endocrinology and metabolism 1993;77(1):27-32.
1993: Jeffrey S Flier; D E Moller; Alan C Moses; S O'Rahilly; RL Chaiken; FLORIN GRIGORESCU; Dariush Elahi; Barbara B Kahn; J E Weinreb; R Eastman
Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance.
The Journal of clinical endocrinology and metabolism 1993;76(6):1533-41.
1993: Barbara B Kahn; O Pedersen
Suppression of GLUT4 expression in skeletal muscle of rats that are obese from high fat feeding but not from high carbohydrate feeding or genetic obesity.
Endocrinology 1993;132(1):13-22.
1993: Dariush Elahi; M McAloon-Dyke; B A Clark; Barbara B Kahn; J E Weinreb; KL Minaker; G A Wong; L A Morse; R S Brown; M E Shapiro
Sequential evaluation of islet cell responses to glucose in the transplanted pancreas in humans.
American journal of surgery 1993;165(1):15-22.
1992: Peter R Shepherd; G W Gould; C A Colville; S C McCoid; E Michael Gibbs; Barbara B Kahn
Distribution of GLUT3 glucose transporter protein in human tissues.
Biochemical and biophysical research communications 1992;188(1):149-54.
1992: Peter R Shepherd; E Michael Gibbs; C Wesslau; G W Gould; Barbara B Kahn
Human small intestine facilitative fructose/glucose transporter (GLUT5) is also present in insulin-responsive tissues and brain. Investigation of biochemical characteristics and translocation.
Diabetes 1992;41(10):1360-5.
1992: Barbara B Kahn
Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes.
The Journal of clinical investigation 1992;89(5):1367-74.
1992: Barbara B Kahn; A S Rosen; J F Bak; P H Andersen; P Damsbo; S Lund; O Pedersen
Expression of GLUT1 and GLUT4 glucose transporters in skeletal muscle of humans with insulin-dependent diabetes mellitus: regulatory effects of metabolic factors.
The Journal of clinical endocrinology and metabolism 1992;74(5):1101-9.
1992: RC Frederich; Barbara B Kahn; M J Peach; Jeffrey S Flier
Tissue-specific nutritional regulation of angiotensinogen in adipose tissue.
Hypertension 1992;19(4):339-44.
1991: M Tal; Barbara B Kahn; Harvey Lodish
Expression of the low Km GLUT-1 glucose transporter is turned on in perivenous hepatocytes of insulin-deficient diabetic rats.
Endocrinology 1991;129(4):1933-41.
1991: Barbara B Kahn; L Rossetti; Harvey Lodish; Maureen J Charron
Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats.
The Journal of clinical investigation 1991;87(6):2197-206.
1991: Barbara B Kahn; G I Shulman; Ralph DeFronzo; S W Cushman; L Rossetti
Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.
The Journal of clinical investigation 1991;87(2):561-70.
1990: O Pedersen; J F Bak; P H Andersen; S Lund; D E Moller; J S Flier; Barbara B Kahn
Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM.
Diabetes 1990;39(7):865-70.
1990: B Thorens; J S Flier; Harvey Lodish; Barbara B Kahn
Differential regulation of two glucose transporters in rat liver by fasting and refeeding and by diabetes and insulin treatment.
Diabetes 1990;39(6):712-9.
1990: Maureen J Charron; Barbara B Kahn
Divergent molecular mechanisms for insulin-resistant glucose transport in muscle and adipose cells in vivo.
The Journal of biological chemistry 1990;265(14):7994-8000.
1989: Barbara B Kahn; Maureen J Charron; Harvey Lodish; S W Cushman; J S Flier
Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats.
The Journal of clinical investigation 1989;84(2):404-11.
1989: Barbara B Kahn; S W Cushman; Jeffrey S Flier
Regulation of glucose transporter-specific mRNA levels in rat adipose cells with fasting and refeeding. Implications for in vivo control of glucose transporter number.
The Journal of clinical investigation 1989;83(1):199-204.