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Ronald Kahn

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Matthew J Rardin; Birgit Schilling; Dylan J Sorensen; Eric Verdin; Jason M Held; C Ronald Kahn; Biao Li; Sean D Mooney; John C Newman; Michael P Cusack; Bradford W Gibson
Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
Ryo Suzuki; Eleftheria Maratos-Flier; Melissa J Chee; Heather A Ferris; C Ronald Kahn
Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function.
Helge Raeder; Mette Vesterhus; Abdelfattah El Ouaamari; Steven P Gygi; Jiang Hu; C Ronald Kahn; Dan Kawamori; Chong Wee Liew; Fiona E McAllister; Anders Molven; Pål R Njølstad; Joao A Paulo; Rohit N Kulkarni
Absence of Diabetes and Pancreatic Exocrine Dysfunction in a Transgenic Model of Carboxyl-Ester Lipase-MODY (Maturity-Onset Diabetes of the Young).

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2013: Matthew J Rardin; Birgit Schilling; Dylan J Sorensen; Eric Verdin; Jason M Held; C Ronald Kahn; Biao Li; Sean D Mooney; John C Newman; Michael P Cusack; Bradford W Gibson
Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):6601-6.
2013: Ryo Suzuki; Eleftheria Maratos-Flier; Melissa J Chee; Heather A Ferris; C Ronald Kahn
Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function.
PLoS biology 2013;11(4):e1001532.
2013: Helge Raeder; Mette Vesterhus; Abdelfattah El Ouaamari; Steven P Gygi; Jiang Hu; C Ronald Kahn; Dan Kawamori; Chong Wee Liew; Fiona E McAllister; Anders Molven; Pål R Njølstad; Joao A Paulo; Rohit N Kulkarni
Absence of Diabetes and Pancreatic Exocrine Dysfunction in a Transgenic Model of Carboxyl-Ester Lipase-MODY (Maturity-Onset Diabetes of the Young).
PloS one 2013;8(4):e60229.
2012: Cecile VERNOCHET; Cristina M Zingaretti; Nils-Göran Larsson; Kevin Y Lee; Yazmín Macotela; Arnaud Mourier; Christopher B Newgard; Matthew J Rardin; Graham Smyth; Ding An; Olivier Bezy; Jeremie Boucher; Saverio Cinti; Brice Emanuelli; Bradford W Gibson; Olga R Ilkayeva; C Ronald Kahn
Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance.
Cell metabolism 2012;16(6):765-76.
2012: Cecile VERNOCHET; C Ronald Kahn
Mitochondria, obesity and aging.
Aging 2012;4(12):859-60.
2012: Kevin Y Lee; C Ronald Kahn
Turning on brown fat and muscle metabolism: hedging your bets.
Cell 2012;151(2):248-50.
2012: Marcelo A Mori; Prashant Raghavan; Stacey Robida-Stubbs; Steven J Russell; Thomas Thomou; T Keith Blackwell; Jeremie Boucher; James L Kirkland; Yazmin Macotela; C Ronald Kahn
Role of microRNA processing in adipose tissue in stress defense and longevity.
Cell metabolism 2012;16(3):336-47.
2012: Christian Rask-Madsen; C Ronald Kahn
Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(9):2052-9.
2012: Aaron M Cypess; Jeffrey English; Ashley R Holman; Gerald M Kolodny; Matthew R Palmer; Cathy Sze; Ilan Tal; Ke Wang; Onyee Chan; Yih-Chieh Chen; C Ronald Kahn
Cold but not sympathomimetics activates human brown adipose tissue in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(25):10001-5.
2012: Florian W Kiefer; Shriram Nallamshetty; Patrick O'Brien; Steffen Spoerl; Thomas M Stulnig; Cecile VERNOCHET; Maximilian Zeyda; Jonathan D Brown; David E Cohen; C Ronald Kahn; Jorge Plutzky
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue.
Nature medicine 2012;18(6):918-25.
2012: Birgit Schilling; Dylan J Sorensen; Eric Verdin; Christine C Wu; Anna M Zawadzka; Michael S Bereman; Michael P Cusack; Barbara E Frewen; Enxuan Jing; C Ronald Kahn; Michael J Maccoss; Brendan X MacLean; Matthew J Rardin; Bradford W Gibson
Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation.
Molecular & cellular proteomics : MCP 2012;11(5):202-14.
2012: Jane Palsgaard; Grzegorz Sumara; Jonathon N Winnay; Brice Emanuelli; Gerard Karsenty; C Ronald Kahn
Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5).
The Journal of biological chemistry 2012;287(15):12016-26.
2012: Kim Zarse; Sebastian Schmeisser; Gregor Beuster; Marco Groth; Reinhard Guthke; C Ronald Kahn; Doreen Kuhlow; Matthias Platzer; Steffen Priebe; Michael Ristow
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal.
Cell metabolism 2012;15(4):451-65.
2012: Mini Sajan; Mildred Acevedo-Duncan; Ursula Braun; Alan P Fields; C Ronald Kahn; Michael Leitges; Stephen Mastorides; Sonali Nimal; Robert V Farese
Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι.
Metabolism: clinical and experimental 2012;61(4):459-69.
2012: Mingjian Lu; Bobby R Monks; Kohjiro Ueki; Min Wan; Qingwei Chu; Sully Fernandez; C Ronald Kahn; Karla F Leavens; Rexford S Ahima; Morris J Birnbaum
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1.
Nature medicine 2012;18(3):388-95.
2012: Jeremie Boucher; Matthias Blüher; Kevin Y Lee; Chong Wee Liew; Yazmin Macotela; Marcelo A Mori; Michael Rourk; Steven J Russell; Graham Smyth; C Ronald Kahn
Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling.
Nature communications 2012;3():902.
2011: Matthew David Hirschey; Enxuan Jing; C Ronald Kahn; Sanjay Kakar; Johanna Kuusisto; Markku Laakso; Maggie M Lam; Michael J Muehlbauer; Christopher B Newgard; Bjoern Schwer; Tadahiro Shimazu; Alena Stančáková; Robert D Stevens; Frederick W Alt; Bradley Aouizerat; Nathan M Bass; Amy M Collins; Robert V Farese; Eric Goetzman; Carrie A Grueter; Eric Verdin
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Molecular cell 2011;44(2):177-90.
2011: Kevin Y Lee; Xiaohui L Wang; Jeremie Boucher; Stephane Gesta; C Ronald Kahn
The differential role of Hif1β/Arnt and the hypoxic response in adipose function, fibrosis, and inflammation.
Cell metabolism 2011;14(4):491-503.
2011: Enxuan Jing; Jeremie Boucher; Brice Emanuelli; Matthew David Hirschey; Kevin Y Lee; David Lombard; Eric M Verdin; C Ronald Kahn
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(35):14608-13.
2011: Olivier Bezy; Thien T Tran; Jussi Pihlajamäki; Ryo Suzuki; Brice Emanuelli; Jonathan Winnay; Marcelo A Mori; Joel Haas; Sudha B Biddinger; Michael Leitges; Allison B Goldfine; Mary Elizabeth Patti; George L King; C Ronald Kahn
PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans.
The Journal of clinical investigation 2011;121(6):2504-17.
2011: Marcelo A Mori; Olivier Bezy; C Ronald Kahn
Metabolic syndrome: is Nlrp3 inflammasome a trigger or a target of insulin resistance?
Circulation research 2011;108(10):1160-2.
2011: Stephane Gesta; Olivier Bezy; Marcelo A Mori; Yazmin Macotela; Kevin Y Lee; C Ronald Kahn
Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(7):2771-6.
2011: Agnieszka A Kendrick; Mahua Choudhury; Rahman Shaikh; Carrie E McCurdy; Marisa Friederich; Johan L K Van Hove; Peter A Watson; Nicholas Birdsey; Jianjun Bao; David Gius; Michael N Sack; Enxuan Jing; C Ronald Kahn; Jacob E Friedman; Karen R Jonscher
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.
The Biochemical journal 2011;433(3):505-14.
2011: Yazmin Macotela; Anneli M Bång; Kirk Beebe; Jeremie Boucher; Brice Emanuelli; Daniel O Espinoza; Walter Gall; C Ronald Kahn
Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism.
PloS one 2011;6(6):e21187.
2010: Kazuma Kaneko; Kohjiro Ueki; Noriko Takahashi; Shinji Hashimoto; Masayuki Okamoto; Motoharu Awazawa; Yukiko Okazaki; Miho Ohsugi; Kazunori Inabe; Toshihiro Umehara; Masashi Yoshida; Masafumi Kakei; Tadahiro Kitamura; Ji Luo; Rohit N Kulkarni; C Ronald Kahn; Haruo Kasai; Lewis C Cantley; Takashi Kadowaki
Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms.
Cell metabolism 2010;12(6):619-32.
2010: Ryo Suzuki; Kevin Lee; Enxuan Jing; Sudha B Biddinger; Jeffrey G McDonald; Thomas J Montine; Suzanne Craft; C Ronald Kahn
Diabetes and insulin in regulation of brain cholesterol metabolism.
Cell metabolism 2010;12(6):567-79.
2010: Aaron M Cypess; C Ronald Kahn
The role and importance of brown adipose tissue in energy homeostasis.
Current opinion in pediatrics 2010;22(4):478-84.
2010: Cullen M Taniguchi; Jonathon Winnay; Tatsuya Kondo; Roderick T Bronson; Alexander R Guimaraes; José O Alemán; Ji Luo; Gregory Stephanopoulos; Ralph Weissleder; Lewis C Cantley; C Ronald Kahn
The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.
Cancer research 2010;70(13):5305-15.
2010: Shuji Ueda; Sohei Kitazawa; Kota Ishida; Yuki Nishikawa; Megumi Matsui; Hikaru Matsumoto; Takuji Aoki; Shinsuke Nozaki; Tomoya Takeda; Yoshikazu Tamori; Atsu Aiba; C Ronald Kahn; Tohru Kataoka; Takaya Satoh
Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(7):2254-61.
2010: Yu-Hua Tseng; Aaron M Cypess; C Ronald Kahn
Cellular bioenergetics as a target for obesity therapy.
Nature reviews. Drug discovery 2010;9(6):465-82.
2010: Christian Rask-Madsen; Qian Li; Bryn Freund; Danielle Feather; Roman Abramov; I-Hsien Wu; Kai Chen; Junko Yamamoto-Hiraoka; Jan Goldenbogen; Konstantinos B Sotiropoulos; Allen Clermont; Pedro Geraldes; Claudia Dall'Osso; Amy J Wagers; Paul L Huang; Mark Rekhter; Rosario Scalia; C Ronald Kahn; George L King
Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice.
Cell metabolism 2010;11(5):379-89.
2010: Jan Mauer; Bhagirath Chaurasia; Leona Plum; Thomas Quast; Brigitte Hampel; Matthias Blüher; Waldemar Kolanus; C Ronald Kahn; Jens C Brüning
Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance.
PLoS genetics 2010;6(5):e1000938.
2010: Ippei Shimizu; Tohru Minamino; Haruhiro Toko; Sho Okada; Hiroyuki Ikeda; Noritaka Yasuda; Kaoru Tateno; Junji Moriya; Masataka Yokoyama; Aika Nojima; Gou Young Koh; Hiroshi Akazawa; Ichiro Shiojima; C Ronald Kahn; E Dale Abel; Issei Komuro
Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents.
The Journal of clinical investigation 2010;120(5):1506-14.
2010: Yuji Yamamoto; Stephane Gesta; Kevin Y Lee; Thien Tran; Parshin Saadatirad; C Ronald Kahn
Adipose depots possess unique developmental gene signatures.
Obesity (Silver Spring, Md.) 2010;18(5):872-8.
2010: Jonathon N Winnay; Jeremie Boucher; Marcelo A Mori; Kohjiro Ueki; C Ronald Kahn
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response.
Nature medicine 2010;16(4):438-45.
2010: Thien T Tran; C Ronald Kahn
Transplantation of adipose tissue and stem cells: role in metabolism and disease.
Nature reviews. Endocrinology 2010;6(4):195-213.
2010: Aaron M Cypess; C Ronald Kahn
Brown fat as a therapy for obesity and diabetes.
Current opinion in endocrinology, diabetes, and obesity 2010;17(2):143-9.
2010: Clara Bouche; Ximena Lopez; Amy Fleischman; Aaron M Cypess; Sheila O'Shea; Darko Stefanovski; Richard N Bergman; Eduard Rogatsky; Daniel Stein; C Ronald Kahn; Rohit N Kulkarni; Allison B Goldfine
Insulin enhances glucose-stimulated insulin secretion in healthy humans.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(10):4770-5.
2010: Matthew David Hirschey; Tadahiro Shimazu; Eric Goetzman; Enxuan Jing; Bjoern Schwer; David Lombard; Carrie A Grueter; Charles Harris; Sudha Biddinger; Olga R Ilkayeva; Robert D Stevens; Yu Li; Asish K Saha; Neil B Ruderman; James R Bain; Christopher B Newgard; Robert V Farese; Frederick W Alt; C Ronald Kahn; Eric Verdin
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Nature 2010;464(7285):121-5.
2010: Victoria Rotter Sopasakis; Pixu Liu; Ryo Suzuki; Tatsuya Kondo; Jonathon Winnay; Thien T Tran; Tomoichiro Asano; Graham Smyth; Mini P Sajan; Robert V Farese; C Ronald Kahn; Jean J Zhao
Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.
Cell metabolism 2010;11(3):220-30.
2010: Jeremie Boucher; Yazmin Macotela; Olivier Bezy; Marcelo A Mori; Kristina Kriauciunas; C Ronald Kahn
A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.
Science signaling 2010;3(151):ra87.
2009: Hiroyuki Ikeda; Ichiro Shiojima; Yukako Ozasa; Masashi Yoshida; Martin Holzenberger; C Ronald Kahn; Kenneth Walsh; Takashi Igarashi; E Dale Abel; Issei Komuro
Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.
Journal of molecular and cellular cardiology 2009;47(5):664-75.
2009: C Ronald Kahn
Health care reform--need for less emotion and more science.
The Journal of clinical investigation 2009;119(10):2856-7.
2009: Xiaohui L Wang; Ryo Suzuki; Kevin Lee; Thien Tran; Jenny Gunton; Asish K Saha; Mary-Elizabeth Patti; Allison B Goldfine; Neil B Ruderman; Frank J Gonzalez; C Ronald Kahn
Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones.
Cell metabolism 2009;9(5):428-39.
2009: Aaron M Cypess; Sanaz Lehman; Gethin Williams; Ilan Tal; Dean Rodman; Allison B Goldfine; Frank C Kuo; Edwin L Palmer; Yu-Hua Tseng; Alessandro Doria; Gerald M Kolodny; C Ronald Kahn
Identification and importance of brown adipose tissue in adult humans.
The New England journal of medicine 2009;360(15):1509-17.
2008: Andrew W Norris; Michael F Hirshman; Jianrong Yao; Niels Jessen; Nicolas Musi; Lihong Chen; William I Sivitz; Laurie J Goodyear; C Ronald Kahn
Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle.
Endocrinology 2008;149(11):5374-83.
2008: C Ronald Kahn
Medicine. Can we nip obesity in its vascular bud?
Science (New York, N.Y.) 2008;322(5901):542-3.
2008: Alessandro Doria; Mary-Elizabeth Patti; C Ronald Kahn
The emerging genetic architecture of type 2 diabetes.
Cell metabolism 2008;8(3):186-200.
2008: Yu-Hua Tseng; Efi Kokkotou; Tim J Schulz; Tian Lian Huang; Jonathon N Winnay; Cullen M Taniguchi; Thien Tran; Ryo Suzuki; Daniel O Espinoza; Yuji Yamamoto; Molly J Ahrens; Andrew T Dudley; Andrew W Norris; Rohit N Kulkarni; C Ronald Kahn
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.
Nature 2008;454(7207):1000-4.
2008: Ammaji Rajala; Masaki Tanito; Yun Z Le; C Ronald Kahn; Raju V S Rajala
Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells.
The Journal of biological chemistry 2008;283(28):19781-92.
2008: Sudha B Biddinger; Joel T Haas; Bian B Yu; Olivier Bezy; Enxuan Jing; Wenwei Zhang; Terry G Unterman; Martin C Carey; C Ronald Kahn
Hepatic insulin resistance directly promotes formation of cholesterol gallstones.
Nature medicine 2008;14(7):778-82.
2008: Linda Koch; F Thomas Wunderlich; Jost Seibler; A Christine Könner; Brigitte Hampel; Sigrid Irlenbusch; Georg Brabant; C Ronald Kahn; Frieder Schwenk; Jens C Brüning
Central insulin action regulates peripheral glucose and fat metabolism in mice.
The Journal of clinical investigation 2008;118(6):2132-47.
2008: Thien Tran; Yuji Yamamoto; Stephane Gesta; C Ronald Kahn
Beneficial effects of subcutaneous fat transplantation on metabolism.
Cell metabolism 2008;7(5):410-20.
2008: Swasti Tiwari; Nikhil Sharma; pritmohinder Gill; Peter Igarashi; C Ronald Kahn; James B Wade; Carolyn M A Ecelbarger
Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(17):6469-74.
2008: Brice Emanuelli; Delphine Eberlé; Ryo Suzuki; C Ronald Kahn
Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3545-50.
2008: Marcus Krüger; Irina Kratchmarova; Blagoy Blagoev; Yu-Hua Tseng; C Ronald Kahn; Matthias Mann
Dissection of the insulin signaling pathway via quantitative phosphoproteomics.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2451-6.
2008: Sudha B Biddinger; Antonio Hernandez-Ono; Christian Rask-Madsen; Joel T Haas; José O Alemán; Ryo Suzuki; Erez F Scapa; Chhavi Agarwal; Martin C Carey; Gregory Stephanopoulos; David E Cohen; George L King; Henry N Ginsberg; C Ronald Kahn
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.
Cell metabolism 2008;7(2):125-34.
2007: Lin Chang; Jifeng Zhang; Yu-Hua Tseng; Changqing Xie; Jacob Ilany; Jens C Brüning; Zhongcui Sun; Xiaojun Zhu; Taixing Cui; Keith A Youker; Qinglin Yang; Sharlene M Day; C Ronald Kahn; Chen Lab
Rad GTPase deficiency leads to cardiac hypertrophy.
Circulation 2007;116(25):2976-83.
2007: Yusuke Murata; Kaku Tsuruzoe; Junji Kawashima; Noboru Furukawa; Tatsuya Kondo; Hiroyuki Motoshima; Motoyuki Igata; Kayo Taketa; Kazunari Sasaki; Hideki Kishikawa; C Ronald Kahn; Tetsushi Toyonaga; Eiichi Araki
IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance.
Biochemical and biophysical research communications 2007;364(2):301-7.
2007: Kathleen A Page; Stephanie Dejardin; C Ronald Kahn; Rohit N Kulkarni; Kevan C Herold; Silvio E Inzucchi
A patient with type B insulin resistance syndrome, responsive to immune therapy.
Nature clinical practice. Endocrinology & metabolism 2007;3(12):835-40.
2007: Masa Katic; Adam R Kennedy; Igor Leykin; Andrew Norris; Aileen McGettrick; Stephane Gesta; Steven J Russell; Matthias Blüher; Eleftheria Maratos-Flier; C Ronald Kahn
Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice.
Aging cell 2007;6(6):827-39.
2007: J Andrew Pospisilik; Claude Knauf; Nicholas Joza; Paule Benit; Michael Orthofer; Patrice Cani; Ingo Ebersberger; Tomoki Nakashima; Renu Sarao; Gregory Neely; Harald Esterbauer; Andrey Kozlov; C Ronald Kahn; Guido Kroemer; Pierre Rustin; Rémy Burcelin; Josef M Penninger
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes.
Cell 2007;131(3):476-91.
2007: Brian D Fink; Judy A Herlein; Katrine Almind; Saverio Cinti; C Ronald Kahn; William I Sivitz
Mitochondrial proton leak in obesity-resistant and obesity-prone mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(5):R1773-80.
2007: Stephane Gesta; Yu-Hua Tseng; C Ronald Kahn
Developmental origin of fat: tracking obesity to its source.
Cell 2007;131(2):242-56.
2007: Olivier Bezy; Cecile VERNOCHET; Stephane Gesta; Stephen R Farmer; C Ronald Kahn
TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity.
Molecular and cellular biology 2007;27(19):6818-31.
2007: Steven J Russell; C Ronald Kahn
Endocrine regulation of ageing.
Nature reviews. Molecular cell biology 2007;8(9):681-91.
2007: Bingzhong Xue; Young-Bum Kim; Anna Lee; Elena Toschi; Susan Bonner-Weir; C Ronald Kahn; Benjamin G Neel; Barbara B Kahn
Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
The Journal of biological chemistry 2007;282(33):23829-40.
2007: Shmuel E Cohen; Efi Kokkotou; Sudha B Biddinger; Tatsuya Kondo; Rolf Gebhardt; Jürgen Kratzsch; Christos S Mantzoros; C Ronald Kahn
High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice.
The Journal of biological chemistry 2007;282(32):23672-8.
2007: Enxuan Jing; Stephane Gesta; C Ronald Kahn
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.
Cell metabolism 2007;6(2):105-14.
2007: Robert V Farese; Mini P Sajan; Hong Yang; Pengfei Li; Steven Mastorides; William R Gower; Sonali Nimal; Cheol Soo Choi; Sheene Kim; Gerald I Shulman; C Ronald Kahn; Ursula Braun; Michael Leitges
Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.
The Journal of clinical investigation 2007;117(8):2289-301.
2007: Sarah Mouche; Sanae Ben Mkaddem; Wei Wang; Masa Katic; Yu-Hua Tseng; Stephanie Carnesecchi; Klaus Steger; Michelangelo Foti; Christoph A Meier; Patrick Muzzin; C Ronald Kahn; Eric Ogier-Denis; Ildiko Szanto
Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation.
Biochimica et biophysica acta 2007;1773(7):1015-27.
2007: A Christine Könner; Ruth Janoschek; Leona Plum; Sabine D Jordan; Eva Rother; Xiaosong Ma; Chun Xu; Pablo J Enriori; Brigitte Hampel; Gregory S Barsh; C Ronald Kahn; Michael Alexander cowley; Frances M Ashcroft; Jens C Brüning
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.
Cell metabolism 2007;5(6):438-49.
2007: Rohit N Kulkarni; C Ronald Kahn
Ephs and ephrins keep pancreatic Beta cells connected.
Cell 2007;129(2):241-3.
2007: Cullen M Taniguchi; José O Aleman; Kohjiro Ueki; Ji Luo; Tomoichiro Asano; Hideaki Kaneto; Gregory Stephanopoulos; Lewis C Cantley; C Ronald Kahn
The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
Molecular and cellular biology 2007;27(8):2830-40.
2007: Palle G Laustsen; Steven J Russell; Lei Cui; Amelia Entingh-Pearsall; Martin Holzenberger; Ronglih Liao; C Ronald Kahn
Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function.
Molecular and cellular biology 2007;27(5):1649-64.
2007: Katrine Almind; Monia Manieri; William I Sivitz; Saverio Cinti; C Ronald Kahn
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2366-71.
2006: Ho-Jin Koh; David E Arnolds; Nobuharu Fujii; Thien Tran; Marc J Rogers; Niels Jessen; Yangfeng Li; Chong Wee Liew; Richard C Ho; Michael F Hirshman; Rohit N Kulkarni; C Ronald Kahn; Laurie J Goodyear
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.
Molecular and cellular biology 2006;26(22):8217-27.
2006: Cullen M Taniguchi; Thien Tran; Tatsuya Kondo; Ji Luo; Kohjiro Ueki; Lewis C Cantley; C Ronald Kahn
Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):12093-7.
2006: Sudha B Biddinger; Makoto Miyazaki; Jeremie Boucher; James M Ntambi; C Ronald Kahn
Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c.
Diabetes 2006;55(7):2032-41.
2006: Cullen M Taniguchi; Tatsuya Kondo; Mini P Sajan; Ji Luo; Roderick Bronson; Tomoichiro Asano; Robert Farese; Lewis C Cantley; C Ronald Kahn
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.
Cell metabolism 2006;3(5):343-53.
2006: Kohjiro Ueki; Terumasa Okada; Jiang Hu; Chong Wee Liew; Anke Assmann; Gabriella M Dahlgren; Jennifer L Peters; Jonathan G Shackman; Min Zhang; Isabella Artner; Leslie S Satin; Roland Stein; Martin Holzenberger; Robert T Kennedy ; C Ronald Kahn; Rohit N Kulkarni
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.
Nature genetics 2006;38(5):583-8.
2006: Stephane Gesta; Matthias Blüher; Yuji Yamamoto; Andrew W Norris; Janin Berndt; Susan Kralisch; Jeremie Boucher; Choy Lewis; C Ronald Kahn
Evidence for a role of developmental genes in the origin of obesity and body fat distribution.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(17):6676-81.
2006: Hiroshi Inoue; Wataru Ogawa; Akihiro Asakawa; Yasuo Okamoto; Akihiko Nishizawa; Michihiro Matsumoto; Kiyoshi Teshigawara; Yasushi Matsuki; Eijiro Watanabe; Ryuji Hiramatsu; Kenji Notohara; Koji Katayose; Hitoshi Okamura; C Ronald Kahn; Tetsuo Noda; Kiyoshi Takeda; Shizuo Akira; Akio Inui; Masato Kasuga
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.
Cell metabolism 2006;3(4):267-75.
2006: Julia Baumgartl; Stephanie Baudler; Maximilian Scherner; Vladimir Babaev; Liza Hayes; Jill Suttles; Marcia McDuffie; Kazuyuki Tobe; Takashi Kadowaki; Sergio Fazio; C Ronald Kahn; Gökhan S Hotamisligil; Wilhelm Krone; MacRae F Linton; Jens C Brüning
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.
Cell metabolism 2006;3(4):247-56.
2006: Zhiheng He; Darren M Opland; Kerrie J Way; Kohjiro Ueki; Natalya Bodyak; Peter M Kang; Seigo Izumo; Rohit N Kulkarni; Bo Wang; Ronglih Liao; C Ronald Kahn; George L King
Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):787-93.
2006: Jacob Ilany; Philip J Bilan; Sonia Kapur; James S Caldwell; Mary-Elizabeth Patti; André Marette; C Ronald Kahn
Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4481-6.
2006: Cullen M Taniguchi; Brice Emanuelli; C Ronald Kahn
Critical nodes in signalling pathways: insights into insulin action.
Nature reviews. Molecular cell biology 2006;7(2):85-96.
2006: Andrew W Norris; C Ronald Kahn
Analysis of gene expression in pathophysiological states: balancing false discovery and false negative rates.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(3):649-53.
2006: Sudha B Biddinger; C Ronald Kahn
From mice to men: insights into the insulin resistance syndromes.
Annual review of physiology 2006;68():123-58.
2005: Claude Knauf; Patrice Cani; Christophe Perrin; Miguel A Iglesias; Jean François Maury; Elodie Bernard; Fadila Benhamed; Thierry Grémeaux; Daniel J Drucker; C Ronald Kahn; JEAN R GIRARD; Jean-François Tanti; Nathalie M Delzenne; Catherine Postic; Rémy Burcelin
Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage.
The Journal of clinical investigation 2005;115(12):3554-63.
2005: Linda A Barbour; Shaikh Mizanoor Rahman; Inga Gurevich; J Wayne Leitner; Stephanie J Fischer; Michael D Roper; Trina A Knotts; Yen Vo; Carrie E McCurdy; Shoshana Yakar; Derek LeRoith; C Ronald Kahn; Lewis C Cantley; Jacob E Friedman; Boris Draznin
Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.
The Journal of biological chemistry 2005;280(45):37489-94.
2005: Young-Bum Kim; Odile D Peroni; william aschenbach; Yasuhiko Minokoshi; Ko Kotani; Ariel Zisman; C Ronald Kahn; Laurie J Goodyear; Barbara B Kahn
Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism.
Molecular and cellular biology 2005;25(21):9713-23.
2005: Kohjiro Ueki; Takashi Kadowaki; C Ronald Kahn
Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome.
Hepatology research : the official journal of the Japan Society of Hepatology 2005;33(2):185-92.
2005: Hiroshi Kurosu; Masaya Yamamoto; Jeremy D Clark; Johanne V Pastor; Animesh Nandi; Prem Gurnani; Owen P McGuinness; Hirotaka Chikuda; Masayuki Yamaguchi; Hiroshi Kawaguchi; Iichiro Shimomura; Yoshiharu Takayama; Joachim Herz; C Ronald Kahn; Kevin P Rosenblatt; Makoto Kuro-o
Suppression of aging in mice by the hormone Klotho.
Science (New York, N.Y.) 2005;309(5742):1829-33.
2005: Jenny Gunton; Rohit N Kulkarni; SunHee Yim; Terumasa Okada; Wayne J Hawthorne; Yu-Hua Tseng; Russell S Roberson; Camillo Ricordi; Philip J O'Connell; Frank J Gonzalez; C Ronald Kahn
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.
Cell 2005;122(3):337-49.
2005: Yu-Hua Tseng; Atul Butte; Efi Kokkotou; Vijay K Yechoor; Cullen M Taniguchi; Kristina M Kriauciunas; Aaron M Cypess; Michio Niinobe; Kazuaki Yoshikawa; Mary-Elizabeth Patti; C Ronald Kahn
Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin.
Nature cell biology 2005;7(6):601-11.
2005: Simon J Fisher; Jens C Brüning; Scott Lannon; C Ronald Kahn
Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia.
Diabetes 2005;54(5):1447-51.
2005: Sudha B Biddinger; Katrine Almind; Makoto Miyazaki; Efi Kokkotou; James M Ntambi; C Ronald Kahn
Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome.
Diabetes 2005;54(5):1314-23.
2005: Mingui Fu; Jifeng Zhang; Yu-Hua Tseng; Taixing Cui; Xiaojun Zhu; Yan Xiao; Yongshan Mou; Hector De Leon; Mary M J Chang; Yasuo Hamamori; C Ronald Kahn; Chen Lab
Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration.
Circulation 2005;111(8):1071-7.
2005: Aileen McGettrick; Edward P Feener; C Ronald Kahn
Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation.
The Journal of biological chemistry 2005;280(8):6441-6.
2005: Nadeeja Wijesekara; Daniel Konrad; Mohamed Eweida; Craig Jefferies; Nicole Liadis; Adria Giacca; Michael A Crackower; Akira Suzuki; Tak W Mak; C Ronald Kahn; Amira Klip; Minna Woo
Muscle-specific Pten deletion protects against insulin resistance and diabetes.
Molecular and cellular biology 2005;25(3):1135-45.
2005: Joel R L Ehrenkranz; Norman G Lewis; C Ronald Kahn; Jesse Roth
Phlorizin: a review.
Diabetes/metabolism research and reviews 2005;21(1):31-8.
2004: Atsushi Miura; Mini P Sajan; Mary L Standaert; Gautam Bandyopadhyay; C Ronald Kahn; Robert V Farese
Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes.
Biochemistry 2004;43(49):15503-9.
2004: Katrine Almind; C Ronald Kahn
Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice.
Diabetes 2004;53(12):3274-85.
2004: Vijay K Yechoor; Mary-Elizabeth Patti; Kohjiro Ueki; Palle G Laustsen; Robert Saccone; Ravi Rauniyar; C Ronald Kahn
Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16525-30.
2004: C Ronald Kahn; Jesse Roth
Berson, Yalow, and the JCI: the agony and the ecstasy.
The Journal of clinical investigation 2004;114(8):1051-4.
2004: Clara Bouché; Shanti Serdy; C Ronald Kahn; Allison B Goldfine
The cellular fate of glucose and its relevance in type 2 diabetes.
Endocrine reviews 2004;25(5):807-30.
2004: Steven D Mason; Richard A Howlett; Matthew J Kim; I Mark Olfert; Michael C Hogan; Wayne McNulty; Reed P Hickey; Peter D Wagner; C Ronald Kahn; Frank J Giordano; Randall S Johnson
Loss of skeletal muscle HIF-1alpha results in altered exercise endurance.
PLoS biology 2004;2(10):e288.
2004: Amelia Entingh-Pearsall; C Ronald Kahn
Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I.
The Journal of biological chemistry 2004;279(36):38016-24.
2004: Tatsuya Kondo; C Ronald Kahn
Altered insulin signaling in retinal tissue in diabetic states.
The Journal of biological chemistry 2004;279(36):37997-8006.
2004: Rohit N Kulkarni; Ulupi S Jhala; Jonathon Winnay; Stan Krajewski; Marc Montminy; C Ronald Kahn
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance.
The Journal of clinical investigation 2004;114(6):828-36.
2004: Matthias Blüher; Leanne Wilson-Fritch; John Leszyk; Palle G Laustsen; Silvia Corvera; C Ronald Kahn
Role of insulin action and cell size on protein expression patterns in adipocytes.
The Journal of biological chemistry 2004;279(30):31902-9.
2004: Matthias Blüher; Mary-Elizabeth Patti; Stephane Gesta; Barbara B Kahn; C Ronald Kahn
Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression.
The Journal of biological chemistry 2004;279(30):31891-901.
2004: Kohjiro Ueki; Tatsuya Kondo; Yu-Hua Tseng; C Ronald Kahn
Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(28):10422-7.
2004: H Joseph Goren; Rohit N Kulkarni; C Ronald Kahn
Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1.
Endocrinology 2004;145(7):3307-23.
2004: Kohjiro Ueki; Tatsuya Kondo; C Ronald Kahn
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms.
Molecular and cellular biology 2004;24(12):5434-46.
2004: Tatsuya Kondo; Ali Hafezi-Moghadam; Kennard Thomas; Denisa D Wagner; C Ronald Kahn
Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier.
Biochemical and biophysical research communications 2004;317(2):315-20.
2004: Anindita Nandi; Yukari Kitamura; C Ronald Kahn; Domenico Accili
Mouse models of insulin resistance.
Physiological reviews 2004;84(2):623-47.
2004: Bertrand Cariou; Catherine Postic; Philippe Boudou; Rémy Burcelin; C Ronald Kahn; JEAN R GIRARD; Anne-Françoise Burnol; Franck Mauvais-Jarvis
Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice.
Endocrinology 2004;145(4):1926-32.
2004: Markus Schubert; Dinesh Gautam; David Surjo; Kojihiko Ueki; Stephanie Baudler; Dominic Schubert; Tatsuya Kondo; Jens Alber; Norbert Galldiks; Eckehardt Küstermann; Saskia Arndt; Andreas H Jacobs; Wilhelm Krone; C Ronald Kahn; Jens C Brüning
Role for neuronal insulin resistance in neurodegenerative diseases.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3100-5.
2004: Yu-Hua Tseng; Kristina M Kriauciunas; Efi Kokkotou; C Ronald Kahn
Differential roles of insulin receptor substrates in brown adipocyte differentiation.
Molecular and cellular biology 2004;24(5):1918-29.
2004: Shmuel E Cohen; Yu-Hua Tseng; M Dodson Michael; C Ronald Kahn
Effects of insulin-sensitising agents in mice with hepatic insulin resistance.
Diabetologia 2004;47(3):407-11.
2004: Rohit N Kulkarni; C Ronald Kahn
Molecular biology. HNFs--linking the liver and pancreatic islets in diabetes.
Science (New York, N.Y.) 2004;303(5662):1311-2.
2004: Esra Asilmaz; Paul Cohen; Makoto Miyazaki; Pawel Dobrzyn; Kohjiro Ueki; Gulnorakhon Fayzikhodjaeva; Alexander A Soukas; C Ronald Kahn; James M Ntambi; Nicholas D Socci; Jeffrey M Friedman
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy.
The Journal of clinical investigation 2004;113(3):414-24.
2004: Tadahiro Kitamura; Yukari Kitamura; Jun Nakae; Antonio Giordano; Saverio Cinti; C Ronald Kahn; Argiris Efstratiadis; Domenico Accili
Mosaic analysis of insulin receptor function.
The Journal of clinical investigation 2004;113(2):209-19.
2004: Dong Chen; Franck Mauvais-Jarvis; Matthias Blüher; Simon J Fisher; Alison C Jozsi; Laurie J Goodyear; Kohjiro Ueki; C Ronald Kahn
p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity.
Molecular and cellular biology 2004;24(1):320-9.
2004: Kenichi Otani; Rohit N Kulkarni; Aaron C Baldwin; Jan Krutzfeldt; Kohjiro Ueki; Markus Stoffel; C Ronald Kahn; Kenneth S Polonsky
Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice.
American journal of physiology. Endocrinology and metabolism 2004;286(1):E41-9.
2003: Kohjiro Ueki; David A Fruman; Claudine M Yballe; Mathias Fasshauer; Johannes Klein; Tomoichiro Asano; Lewis C Cantley; C Ronald Kahn
Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling.
The Journal of biological chemistry 2003;278(48):48453-66.
2003: Allison B Goldfine; C Ronald Kahn
Adiponectin: linking the fat cell to insulin sensitivity.
Lancet 2003;362(9394):1431-2.
2003: Yoshiaki Hirashima; Kaku Tsuruzoe; Shoko Kodama; Motoyuki Igata; Tetsushi Toyonaga; K Ueki; C Ronald Kahn; Eiichi Araki
Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway.
The Journal of endocrinology 2003;179(2):253-66.
2003: Evan D Rosen; Rohit N Kulkarni; pasha sarraf; Umut Ozcan; Terumasa Okada; Chung-Hsin Hsu; Daniel Eisenman; Mark Magnuson; Frank J Gonzalez; C Ronald Kahn; Bruce M Spiegelman
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis.
Molecular and cellular biology 2003;23(20):7222-9.
2003: Yu-Tzu Tai; klaus podar; Laurence Catley; Yu-Hua Tseng; Masaharu Akiyama; Reshma Shringarpure; Renate Burger; Teru Hideshima; Dharminder Chauhan; Nicholas Mitsiades; Paul Richardson; Nikhil C Munshi; C Ronald Kahn; Constantine S Mitsiades; Kenneth C Anderson
Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.
Cancer research 2003;63(18):5850-8.
2003: Alfonso Mora; Anthony M Davies; Luc Bertrand; Isam Sharif; Grant R Budas; Sofija Jovanović; Véronique Mouton; C Ronald Kahn; John M Lucocq; Gillian A Gray; Aleksandar Jovanović; Dario R Alessi
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia.
The EMBO journal 2003;22(18):4666-76.
2003: Yasuhiko Minokoshi; C Ronald Kahn; Barbara B Kahn
Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis.
The Journal of biological chemistry 2003;278(36):33609-12.
2003: Amelia J Entingh; Cullen M Taniguchi; C Ronald Kahn
Bi-directional regulation of brown fat adipogenesis by the insulin receptor.
The Journal of biological chemistry 2003;278(35):33377-83.
2003: Zhen Y Jiang; Zhiheng He; Benjamin L King; Tatsuya Kuroki; Darren M Opland; Kiyoshi Suzuma; Izumi Suzuma; Kohjiro Ueki; Rohit N Kulkarni; C Ronald Kahn; George L King
Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis.
The Journal of biological chemistry 2003;278(34):31964-71.
2003: Andrew W Norris; Lihong Chen; Simon J Fisher; Ildiko Szanto; Michael Ristow; Alison C Jozsi; Michael F Hirshman; Evan D Rosen; Laurie J Goodyear; Frank J Gonzalez; Bruce M Spiegelman; C Ronald Kahn
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.
The Journal of clinical investigation 2003;112(4):608-18.
2003: Christian Wolfrum; David Q Shih; Satoru Kuwajima; Andrew W Norris; C Ronald Kahn; Markus Stoffel
Role of Foxa-2 in adipocyte metabolism and differentiation.
The Journal of clinical investigation 2003;112(3):345-56.
2003: Mary-Elizabeth Patti; Atul Butte; Sarah Crunkhorn; Kenneth Cusi; Rachele Berria; Sangeeta Kashyap; Yoshinori Miyazaki; Isaac Kohane; Maura Costello; Robert Saccone; Edwin J Landaker; Allison B Goldfine; Edward C Mun; Ralph DeFronzo; Jean Finlayson; C Ronald Kahn; Lawrence J. Manderino
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8466-71.
2003: C Ronald Kahn
Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes.
Experimental diabesity research 2003;4(3):169-82.
2003: Tatsuya Kondo; David Vicent; Kiyoshi Suzuma; Masashi Yanagisawa; George L King; Martin Holzenberger; C Ronald Kahn
Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.
The Journal of clinical investigation 2003;111(12):1835-42.
2003: Jocelyne Magré; Marc Delépine; Lionel Van Maldergem; Jean-Jacques Robert; J Antonie Maassen; Muriel Meier; Vanessa R Panz; Chong A Kim; Nadia Tubiana-Rufi; Paul Czernichow; Eva Seemanova; Charles R Buchanan; Didier Lacombe; Corinne Vigouroux; Olivier Lascols; C Ronald Kahn; Jacqueline Capeau; Mark Lathrop
Prevalence of mutations in AGPAT2 among human lipodystrophies.
Diabetes 2003;52(6):1573-8.
2003: Katrine Almind; Rohit N Kulkarni; Scott M Lannon; C Ronald Kahn
Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance.
Diabetes 2003;52(6):1535-43.
2003: Rohit N Kulkarni; Katrine Almind; H Joseph Goren; Jonathon Winnay; Kohjiro Ueki; Terumasa Okada; C Ronald Kahn
Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice.
Diabetes 2003;52(6):1528-34.
2003: Rémy Burcelin; Valérie Crivelli; Christophe Perrin; Anabela Da Costa; James Mu; Barbara B Kahn; Morris J Birnbaum; C Ronald Kahn; Peter Vollenweider; Bernard Thorens
GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization.
The Journal of clinical investigation 2003;111(10):1555-62.
2003: David Vicent; Jacob Ilany; Tatsuya Kondo; Keiko Naruse; Simon J Fisher; Yaz Y Kisanuki; Sven-Erik Bursell; Masashi Yanagisawa; George L King; C Ronald Kahn
The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance.
The Journal of clinical investigation 2003;111(9):1373-80.
2003: Angela M Valverde; Mónica Arribas; Cecilia Mur; Paloma Navarro; Sebastián Pons; Anne-Marie Cassard-Doulcier; C Ronald Kahn; Manuel Benito
Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes.
The Journal of biological chemistry 2003;278(12):10221-31.
2003: Allison B Goldfine; Clara Bouche; Robert A Parker; Caroline Kim; Amy Kerivan; J Stuart Soeldner; Blaise C Martin; James H Warram; C Ronald Kahn
Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2724-9.
2003: Daniel Hallmann; Katja Trümper; Heidi Trusheim; Kohjiro Ueki; C Ronald Kahn; Lewis C Cantley; David A Fruman; Dieter Hörsch
Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha.
The Journal of biological chemistry 2003;278(7):5099-108.
2003: Simon J Fisher; C Ronald Kahn
Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production.
The Journal of clinical investigation 2003;111(4):463-8.
2003: Matthias Blüher; Barbara B Kahn; C Ronald Kahn
Extended longevity in mice lacking the insulin receptor in adipose tissue.
Science (New York, N.Y.) 2003;299(5606):572-4.
2003: C Ronald Kahn
The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice.
Transactions of the American Clinical and Climatological Association 2003;114():125-48.
2003: Tadahiro Kitamura; C Ronald Kahn; Domenico Accili
Insulin receptor knockout mice.
Annual review of physiology 2003;65():313-32.
2002: Palle G Laustsen; M Dodson Michael; Barbara E Crute; Shmuel E Cohen; Kohjiro Ueki; Rohit N Kulkarni; Susanna R Keller; Gustav E Lienhard; C Ronald Kahn
Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice.
Genes & development 2002;16(24):3213-22.
2002: Ichiro Shiojima; Mikkael Yefremashvili; Zhengyu Luo; Yasuko Kureishi; Akihiro Takahashi; Jingzang Tao; Anthony Rosenzweig; C Ronald Kahn; E Dale Abel; Kenneth Walsh
Akt signaling mediates postnatal heart growth in response to insulin and nutritional status.
The Journal of biological chemistry 2002;277(40):37670-7.
2002: Michael A Crackower; Gavin Y Oudit; Ivona Kozieradzki; Renu Sarao; Hui Sun; Takehiko Sasaki; Emilio Hirsch; Akira Suzuki; Tetsuo Shioi; Junko Irie-Sasaki; Rajan Sah; Hai-Ying M Cheng; Vitalyi O Rybin; Giuseppe Lembo; Luigi Fratta; Antonio J Oliveira-dos-Santos; Jeffery L Benovic; C Ronald Kahn; Seigo Izumo; Susan F Steinberg; Matthias P Wymann; Peter H Backx; Josef M Penninger
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.
Cell 2002;110(6):737-49.
2002: Yu-Hua Tseng; Kohjiro Ueki; Kristina M Kriauciunas; C Ronald Kahn
Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin.
The Journal of biological chemistry 2002;277(35):31601-11.
2002: Vijay K Yechoor; Mary-Elizabeth Patti; Robert Saccone; C Ronald Kahn
Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10587-92.
2002: Atsuhisa Shirakami; Tetsushi Toyonaga; Kaku Tsuruzoe; Tetsuya Shirotani; Kazuya Matsumoto; Kazuaki Yoshizato; Junji Kawashima; Yoshiaki Hirashima; Nobuhiro Miyamura; C Ronald Kahn; Eiichi Araki
Heterozygous knockout of the IRS-1 gene in mice enhances obesity-linked insulin resistance: a possible model for the development of type 2 diabetes.
The Journal of endocrinology 2002;174(2):309-19.
2002: Matthias Blüher; M Dodson Michael; Odile D Peroni; Kohjiro Ueki; Nathan Carter; Barbara B Kahn; C Ronald Kahn
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance.
Developmental cell 2002;3(1):25-38.
2002: Franck Mauvais-Jarvis; Rohit N Kulkarni; C Ronald Kahn
Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance.
Clinical endocrinology 2002;57(1):1-9.
2002: Petra Jost; Mathias Fasshauer; C Ronald Kahn; Manuel Benito; Marco Meyer; Volker Ott; Bradford B Lowell; Harald H Klein; Johannes Klein
Atypical beta-adrenergic effects on insulin signaling and action in beta(3)-adrenoceptor-deficient brown adipocytes.
American journal of physiology. Endocrinology and metabolism 2002;283(1):E146-53.
2002: Isabelle Hamer; Michelangelo Foti; R Emkey; Martine Cordier-Bussat; Jacques Philippe; Pierre De Meyts; Christine Maeder; C Ronald Kahn; Jean-Louis Carpentier
An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events.
Diabetologia 2002;45(5):657-67.
2002: Rohit N Kulkarni; Martin Holzenberger; D Q Shih; Umut Ozcan; M Stoffel; Mark Magnuson; C Ronald Kahn
beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.
Nature genetics 2002;31(1):111-5.
2002: Johannes Klein; Mathias Fasshauer; Harald H Klein; Manuel Benito; C Ronald Kahn
Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action.
BioEssays : news and reviews in molecular, cellular and developmental biology 2002;24(4):382-8.
2002: Sarah A Shoichet; Anselm T Bäumer; Djordje Stamenkovic; Heinrich Sauer; Andreas F H Pfeiffer; C Ronald Kahn; Dirk Müller-Wieland; Christoph Richter; Michael Ristow
Frataxin promotes antioxidant defense in a thiol-dependent manner resulting in diminished malignant transformation in vitro.
Human molecular genetics 2002;11(7):815-21.
2002: Darrell D Belke; Sandrine Betuing; Martin J Tuttle; Christophe Graveleau; Martin E Young; Mark Pham; Dongfang Zhang; Robert C Cooksey; Donald A McClain; Sheldon E Litwin; Heinrich Taegtmeyer; David L Severson; C Ronald Kahn; E Dale Abel
Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression.
The Journal of clinical investigation 2002;109(5):629-39.
2002: Cecilia Mur; Angela M Valverde; C Ronald Kahn; Manuel Benito
Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes.
Diabetes 2002;51(3):743-54.
2002: Katrine Almind; Laurent Delahaye; Torben Hansen; Emmanuel Van Obberghen; Oluf Pedersen; C Ronald Kahn
Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2124-8.
2002: Michael G Roper; Wei-Jun Qian; Bei B Zhang; Rohit N Kulkarni; C Ronald Kahn; Robert T Kennedy
Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells.
Diabetes 2002;51 Suppl 1():S43-9.
2002: Kohjiro Ueki; David A Fruman; Saskia M Brachmann; Yu-Hua Tseng; Lewis C Cantley; C Ronald Kahn
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.
Molecular and cellular biology 2002;22(3):965-77.
2002: Kohjiro Ueki; Claudine M Yballe; Saskia M Brachmann; David Vicent; John M Watt; C Ronald Kahn; Lewis C Cantley
Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):419-24.
2002: Yohei Maeshima; Akulapalli Sudhakar; Julie C Lively; Kohjiro Ueki; Surender Kharbanda; C Ronald Kahn; Nahum Sonenberg; Richard O Hynes; Raghu Kalluri
Tumstatin, an endothelial cell-specific inhibitor of protein synthesis.
Science (New York, N.Y.) 2002;295(5552):140-3.
2002: Franck Mauvais-Jarvis; Kohjiro Ueki; David A Fruman; Michael F Hirshman; Kei Sakamoto; Laurie J Goodyear; Matteo Iannacone; Domenico Accili; Lewis C Cantley; C Ronald Kahn
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.
The Journal of clinical investigation 2002;109(1):141-9.
2001: Alan Saltiel; C Ronald Kahn
Insulin signalling and the regulation of glucose and lipid metabolism.
Nature 2001;414(6865):799-806.
2001: C Guerra; Paloma Navarro; Angela M Valverde; Mónica Arribas; J Brüning; Leslie P Kozak; C Ronald Kahn; Manuel Benito
Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.
The Journal of clinical investigation 2001;108(8):1205-13.
2001: Jason K Kim; Ariel Zisman; Jonathan J Fillmore; Odile D Peroni; Ko Kotani; Pascale Perret; Haihong Zong; Jianying Dong; C Ronald Kahn; Barbara B Kahn; Gerald I Shulman
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4.
The Journal of clinical investigation 2001;108(1):153-60.
2001: S N Flier; Rohit N Kulkarni; C Ronald Kahn
Evidence for a circulating islet cell growth factor in insulin-resistant states.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7475-80.
2001: Angela M Valverde; Cecilia Mur; Sebastián Pons; Alberto M Alvarez; Morris F White; C Ronald Kahn; Manuel Benito
Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis.
Molecular and cellular biology 2001;21(7):2269-80.
2001: C Reynet; C Ronald Kahn
Unbalanced expression of the different subunits of elongation factor 1 in diabetic skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3422-7.
2001: Yu-Hua Tseng; David Vicent; Jun Zhu; Y Niu; Adewale Adeyinka; JS Moyers; P H Watson; C Ronald Kahn
Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23.
Cancer research 2001;61(5):2071-9.
2001: Mathias Fasshauer; Johannes Klein; Kristina M Kriauciunas; Kohjiro Ueki; M Benito; C Ronald Kahn
Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes.
Molecular and cellular biology 2001;21(1):319-29.
2001: K Tsuruzoe; R Emkey; Kristina M Kriauciunas; Kohjiro Ueki; C Ronald Kahn
Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling.
Molecular and cellular biology 2001;21(1):26-38.
2000: Franck Mauvais-Jarvis; A Virkamaki; M Dodson Michael; Jonathon Winnay; A Zisman; Rohit N Kulkarni; C Ronald Kahn
A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.
Diabetes 2000;49(12):2126-34.
2000: C Ronald Kahn; Lu Chen; Shmuel E Cohen
Unraveling the mechanism of action of thiazolidinediones.
The Journal of clinical investigation 2000;106(11):1305-7.
2000: David A Fruman; Franck Mauvais-Jarvis; D A Pollard; Claudine M Yballe; Derek Brazil; R T Bronson; C Ronald Kahn; Lewis C Cantley
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha.
Nature genetics 2000;26(3):379-82.
2000: Kohjiro Ueki; P Algenstaedt; Franck Mauvais-Jarvis; C Ronald Kahn
Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit.
Molecular and cellular biology 2000;20(21):8035-46.
2000: Michael Ristow; M F Pfister; Andrew J Yee; M Schubert; L Michael; Chen-Yu zhang; Kohjiro Ueki; M Dodson Michael; Bradford B Lowell; C Ronald Kahn
Frataxin activates mitochondrial energy conversion and oxidative phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12239-43.
2000: Jens C Brüning; Dinesh Gautam; Deborah J Burks; Jennifer A Gillette; Markus Schubert; P C Orban; R Klein; Wilhelm Krone; Dirk Müller-Wieland; C Ronald Kahn
Role of brain insulin receptor in control of body weight and reproduction.
Science (New York, N.Y.) 2000;289(5487):2122-5.
2000: J Hebinck; Cornelia Hardt; Ludger Schöls; Matthias Vorgerd; L Briedigkeit; C Ronald Kahn; Michael Ristow
Heterozygous expansion of the GAA tract of the X25/frataxin gene is associated with insulin resistance in humans.
Diabetes 2000;49(9):1604-7.
2000: Kristina M Kriauciunas; Martin G Myers Jr; C Ronald Kahn
Cellular compartmentalization in insulin action: altered signaling by a lipid-modified IRS-1.
Molecular and cellular biology 2000;20(18):6849-59.
2000: Mathias Fasshauer; Johannes Klein; Kohjiro Ueki; Kristina M Kriauciunas; M Benito; Morris F White; C Ronald Kahn
Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes.
The Journal of biological chemistry 2000;275(33):25494-501.
2000: Ariel Zisman; Odile D Peroni; E Dale Abel; M Dodson Michael; Franck Mauvais-Jarvis; Bradford B Lowell; J F Wojtaszewski; Michael F Hirshman; A Virkamaki; Laurie J Goodyear; C Ronald Kahn; Barbara B Kahn
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.
Nature medicine 2000;6(8):924-8.
2000: CA Aspinwall; Wei-Jun Qian; Michael G Roper; Rohit N Kulkarni; C Ronald Kahn; Robert T Kennedy
Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells.
The Journal of biological chemistry 2000;275(29):22331-8.
2000: M Dodson Michael; Rohit N Kulkarni; C Postic; Stephen Previs; Gerald I Shulman; Mark Magnuson; C Ronald Kahn
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.
Molecular cell 2000;6(1):87-97.
2000: Jason K Kim; M Dodson Michael; Stephen Previs; Odile D Peroni; Franck Mauvais-Jarvis; Susanne Neschen; Barbara B Kahn; C Ronald Kahn; Gerald I Shulman
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle.
The Journal of clinical investigation 2000;105(12):1791-7.
2000: Jonathon Winnay; Jens C Brüning; Deborah J Burks; C Ronald Kahn
Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts.
The Journal of biological chemistry 2000;275(14):10545-50.
2000: J C Bruning; Jennifer A Gillette; Y Zhao; C Bjorbaeck; Jorg Kotzka; Birgit Knebel; Haluk Avci; Bettina Hanstein; P Lingohr; D E Moller; Wilhelm Krone; C Ronald Kahn; Dirk Müller-Wieland
Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2462-7.
2000: Allison B Goldfine; Mary-Elizabeth Patti; L Zuberi; B J Goldstein; R LeBlanc; Edwin J Landaker; Z Y Jiang; Gail R Willsky; C Ronald Kahn
Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies.
Metabolism: clinical and experimental 2000;49(3):400-10.
2000: David Vicent; Eleftheria Maratos-Flier; C Ronald Kahn
The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis.
Molecular and cellular biology 2000;20(6):2158-66.
2000: I Szanto; C Ronald Kahn
Selective interaction between leptin and insulin signaling pathways in a hepatic cell line.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2355-60.
2000: C Ronald Kahn; Jens C Brüning; M Dodson Michael; Rohit N Kulkarni
Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus.
Journal of pediatric endocrinology & metabolism : JPEM 2000;13 Suppl 6():1377-84.
1999: G Inoue; Bentley Cheatham; C Ronald Kahn
Development of an in vitro reconstitution assay for glucose transporter 4 translocation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):14919-24.
1999: Jun Zhu; Yu-Hua Tseng; J D Kantor; C J Rhodes; Bruce R Zetter; JS Moyers; C Ronald Kahn
Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):14911-8.
1999: D Hörsch; C Ronald Kahn
Region-specific mRNA expression of phosphatidylinositol 3-kinase regulatory isoforms in the central nervous system of C57BL/6J mice.
The Journal of comparative neurology 1999;415(1):105-20.
1999: Johannes Klein; Mathias Fasshauer; M Ito; Bradford B Lowell; M Benito; C Ronald Kahn
beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes.
The Journal of biological chemistry 1999;274(49):34795-802.
1999: Rohit N Kulkarni; Jonathon Winnay; M Daniels; Jens C Brüning; S N Flier; Douglas Hanahan; C Ronald Kahn
Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.
The Journal of clinical investigation 1999;104(12):R69-75.
1999: J F Wojtaszewski; Y Higaki; Michael F Hirshman; M Dodson Michael; Scott D Dufresne; C Ronald Kahn; Laurie J Goodyear
Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice.
The Journal of clinical investigation 1999;104(9):1257-64.
1999: Angela M Valverde; C Ronald Kahn; Manuel Benito
Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.
Diabetes 1999;48(11):2122-31.
1999: Mary-Elizabeth Patti; A Virkamäki; Edwin J Landaker; C Ronald Kahn; Hannele Yki-Järvinen
Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.
Diabetes 1999;48(8):1562-71.
1999: A Virkamäki; Kohjiro Ueki; C Ronald Kahn
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance.
The Journal of clinical investigation 1999;103(7):931-43.
1999: Rohit N Kulkarni; Jens C Brüning; Jonathon Winnay; C Postic; Mark Magnuson; C Ronald Kahn
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
Cell 1999;96(3):329-39.
1998: Jens C Brüning; M Dodson Michael; Jonathon Winnay; Toshiaki Hayashi; D Hörsch; Domenico Accili; Laurie J Goodyear; C Ronald Kahn
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.
Molecular cell 1998;2(5):559-69.
1998: David Vicent; M Piper; S Gammeltoft; Eleftheria Maratos-Flier; C Ronald Kahn
Alterations in skeletal muscle gene expression of ob/ob mice by mRNA differential display.
Diabetes 1998;47(9):1451-8.
1998: Philip J Bilan; JS Moyers; C Ronald Kahn
The ras-related protein rad associates with the cytoskeleton in a non-lipid-dependent manner.
Experimental cell research 1998;242(2):391-400.
1998: JS Moyers; Jun Zhu; C Ronald Kahn
Effects of phosphorylation on function of the Rad GTPase.
The Biochemical journal 1998;333 ( Pt 3)():609-14.
1998: G Inoue; Bentley Cheatham; R Emkey; C Ronald Kahn
Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2.
The Journal of biological chemistry 1998;273(19):11548-55.
1998: Michael Ristow; Eleni Giannakidou; J Hebinck; K Busch; Matthias Vorgerd; Jorg Kotzka; Birgit Knebel; Jan Muller-Berghaus; C Epplen; A Pfeiffer; C Ronald Kahn; A Doria; Wilhelm Krone; Dirk Müller-Wieland
An association between NIDDM and a GAA trinucleotide repeat polymorphism in the X25/frataxin (Friedreich's ataxia) gene.
Diabetes 1998;47(5):851-4.
1998: Mary-Elizabeth Patti; E Brambilla; Livio Luzi; Edwin J Landaker; C Ronald Kahn
Bidirectional modulation of insulin action by amino acids.
The Journal of clinical investigation 1998;101(7):1519-29.
1998: Mary-Elizabeth Patti; C Ronald Kahn
The insulin receptor--a critical link in glucose homeostasis and insulin action.
Journal of basic and clinical physiology and pharmacology 1998;9(2-4):89-109.
1997: N J Kerouz; D Hörsch; S Pons; C Ronald Kahn
Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.
The Journal of clinical investigation 1997;100(12):3164-72.
1997: R Emkey; C Ronald Kahn
Cross-talk between phorbol ester-mediated signaling and tyrosine kinase proto-oncogenes. II. Comparison of phorbol ester and sphingomyelinase-induced phosphorylation of ErbB2 and ErbB3.
The Journal of biological chemistry 1997;272(49):31182-9.
1997: R Emkey; C Ronald Kahn
Cross-talk between phorbol ester-mediated signaling and tyrosine kinase proto-oncogenes. I. Activation of protein kinase C stimulates tyrosine phosphorylation and activation of ErbB2 and ErbB3.
The Journal of biological chemistry 1997;272(49):31172-81.
1997: Jun Zhu; C Ronald Kahn
Analysis of a peptide hormone-receptor interaction in the yeast two-hybrid system.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13063-8.
1997: P Algenstaedt; David Antonetti; M B Yaffe; C Ronald Kahn
Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart.
The Journal of biological chemistry 1997;272(38):23696-702.
1997: J Smith-Hall; S Pons; Mary-Elizabeth Patti; Deborah J Burks; Lynne Yenush; Xiao Jian Sun; C Ronald Kahn; Morris F White
The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells.
Biochemistry 1997;36(27):8304-10.
1997: S J Kim; C Ronald Kahn
Insulin stimulates p70 S6 kinase in the nucleus of cells.
Biochemical and biophysical research communications 1997;234(3):681-5.
1997: JS Moyers; Philip J Bilan; Jun Zhu; C Ronald Kahn
Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II.
The Journal of biological chemistry 1997;272(18):11832-9.
1997: Jens C Brüning; Jonathon Winnay; Bentley Cheatham; C Ronald Kahn
Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells.
Molecular and cellular biology 1997;17(3):1513-21.
1997: Jens C Brüning; Jonathon Winnay; Susan Bonner-Weir; S I Taylor; Domenico Accili; C Ronald Kahn
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.
Cell 1997;88(4):561-72.
1996: Bentley Cheatham; A Volchuk; C Ronald Kahn; L Wang; Christopher J Rhodes; A Klip
Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15169-73.
1996: G Inoue; Bentley Cheatham; C Ronald Kahn
Different pathways of postreceptor desensitization following chronic insulin treatment and in cells overexpressing constitutively active insulin receptors.
The Journal of biological chemistry 1996;271(45):28206-11.
1996: Mary-Elizabeth Patti; C Ronald Kahn
Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus.
Trends in endocrinology and metabolism: TEM 1996;7(9):311-9.
1996: Lício A Velloso; Franco Folli; Xiao Jian Sun; Morris F White; Mario J A Saad; C Ronald Kahn
Cross-talk between the insulin and angiotensin signaling systems.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12490-5.
1996: Franco Folli; S Ghidella; Luca Bonfanti; C Ronald Kahn; Adalberto Merighi
The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system.
Molecular neurobiology 1996;13(2):155-83.
1996: JS Moyers; P J Bilan; C Reynet; C Ronald Kahn
Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells.
The Journal of biological chemistry 1996;271(38):23111-6.
1996: Franco Folli; Mario J A Saad; C Ronald Kahn
Insulin receptor/IRS-1/PI 3-kinase signaling system in corticosteroid-induced insulin resistance.
Acta diabetologica 1996;33(3):185-92.
1996: Katrine Almind; G Inoue; Oluf Pedersen; C Ronald Kahn
A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies.
The Journal of clinical investigation 1996;97(11):2569-75.
1996: David Antonetti; P Algenstaedt; C Ronald Kahn
Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain.
Molecular and cellular biology 1996;16(5):2195-203.
1996: C Reynet; C Ronald Kahn; M R Loeken
Expression of the gene encoding glycogen phosphorylase is elevated in diabetic rat skeletal muscle and is regulated by insulin and cyclic AMP.
Diabetologia 1996;39(2):183-9.
1996: Jun Zhu; P J Bilan; JS Moyers; David Antonetti; C Ronald Kahn
Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin.
The Journal of biological chemistry 1996;271(2):768-73.
1995: A B Goldfine; DC Simonson; Franco Folli; Mary-Elizabeth Patti; C Ronald Kahn
In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus.
Molecular and cellular biochemistry 1995;153(1-2):217-31.
1995: A B Goldfine; DC Simonson; Franco Folli; Mary-Elizabeth Patti; C Ronald Kahn
Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies.
The Journal of clinical endocrinology and metabolism 1995;80(11):3311-20.
1995: Mary-Elizabeth Patti; Xiao Jian Sun; J C Bruening; E Araki; M A Lipes; Morris F White; C Ronald Kahn
4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice.
The Journal of biological chemistry 1995;270(42):24670-3.
1995: E Araki; B L Haag; K Matsuda; M Shichiri; C Ronald Kahn
Characterization and regulation of the mouse insulin receptor substrate gene promoter.
Molecular endocrinology (Baltimore, Md.) 1995;9(10):1367-79.
1995: Martin G Myers Jr; Bentley Cheatham; T L Fisher; B R Jachna; C Ronald Kahn; Jonathan M Backer; Morris F White
Common and distinct elements in insulin and PDGF signaling.
Annals of the New York Academy of Sciences 1995;766():369-87.
1995: J Magré; A B Goldfine; James H Warram; Andrzej S Krolewski; C Ronald Kahn
Analysis of the insulin receptor gene in noninsulin-dependent diabetes mellitus by denaturing gradient gel blots: a clinical research center study.
The Journal of clinical endocrinology and metabolism 1995;80(6):1882-7.
1995: Mario J A Saad; Franco Folli; C Ronald Kahn
Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells.
Endocrinology 1995;136(4):1579-88.
1995: Bentley Cheatham; C Ronald Kahn
Insulin action and the insulin signaling network.
Endocrine reviews 1995;16(2):117-42.
1995: Jun Zhu; C Reynet; J S Caldwell; C Ronald Kahn
Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity.
The Journal of biological chemistry 1995;270(9):4805-12.
1995: David Antonetti; C Reynet; C Ronald Kahn
Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus.
The Journal of clinical investigation 1995;95(3):1383-8.
1995: K Yamada; J L Carpentier; Bentley Cheatham; E Goncalves; Steven E Shoelson; C Ronald Kahn
Role of the transmembrane domain and flanking amino acids in internalization and down-regulation of the insulin receptor.
The Journal of biological chemistry 1995;270(7):3115-22.
1995: A Doria; J S Caldwell; L Ji; C Reynet; S S Rich; S Weremowicz; C C Morton; James H Warram; C Ronald Kahn; Andrzej S Krolewski
Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q.
Diabetes 1995;44(2):243-7.
1995: K Yamada; E Goncalves; J L Carpentier; C Ronald Kahn; Steven E Shoelson
Transmembrane domain inversion blocks ER release and insulin receptor signaling.
Biochemistry 1995;34(3):946-54.
1994: E Araki; M A Lipes; Mary-Elizabeth Patti; Jens C Brüning; B Haag; R S Johnson; C Ronald Kahn
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.
Nature 1994;372(6502):186-90.
1994: L M Chuang; S F Hausdorff; Martin G Myers Jr; Morris F White; Morris J Birnbaum; C Ronald Kahn
Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes.
The Journal of biological chemistry 1994;269(44):27645-9.
1994: Sarah Ferber; J Meyerovitch; K M Kriauciunas; C Ronald Kahn
Vanadate normalizes hyperglycemia and phosphoenolpyruvate carboxykinase mRNA levels in ob/ob mice.
Metabolism: clinical and experimental 1994;43(11):1346-54.
1994: Franco Folli; Luca Bonfanti; E Renard; C Ronald Kahn; Adalberto Merighi
Insulin receptor substrate-1 (IRS-1) distribution in the rat central nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(11 Pt 1):6412-22.
1994: C Ronald Kahn
Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes.
Diabetes 1994;43(8):1066-84.
1994: C Alarcón; Bentley Cheatham; B Lincoln; C Ronald Kahn; K Siddle; Christopher J Rhodes
A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor.
The Biochemical journal 1994;301 ( Pt 1)():257-65.
1994: Bentley Cheatham; C J Vlahos; L Cheatham; L Wang; John Blenis; C Ronald Kahn
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.
Molecular and cellular biology 1994;14(7):4902-11.
1994: P A Wilden; C Ronald Kahn
The level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase, microtubule-associated protein, and S6 kinases.
Molecular endocrinology (Baltimore, Md.) 1994;8(5):558-67.
1994: Mario J A Saad; Franco Folli; E Araki; N Hashimoto; Péter Csermely; C Ronald Kahn
Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone.
Molecular endocrinology (Baltimore, Md.) 1994;8(5):545-57.
1994: A S Edge; A Karasik; K Yamada; C Ronald Kahn
Effect of dexamethasone on the carbohydrate chains of the insulin receptor.
Biochemical and biophysical research communications 1994;200(2):852-9.
1994: E Araki; B L Haag; C Ronald Kahn
Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1.
Biochimica et biophysica acta 1994;1221(3):353-6.
1994: S J Kim; C Ronald Kahn
Insulin stimulates phosphorylation of c-Jun, c-Fos, and Fos-related proteins in cultured adipocytes.
The Journal of biological chemistry 1994;269(16):11887-92.
1994: Morris F White; C Ronald Kahn
The insulin signaling system.
The Journal of biological chemistry 1994;269(1):1-4.
1993: C Reynet; C Ronald Kahn
Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans.
Science (New York, N.Y.) 1993;262(5138):1441-4.
1993: L M Chuang; Martin G Myers Jr; Jonathan M Backer; Steven E Shoelson; Morris F White; M J Birnbaum; C Ronald Kahn
Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase.
Molecular and cellular biology 1993;13(11):6653-60.
1993: S J Kim; C Ronald Kahn
Insulin induces rapid accumulation of insulin receptors and increases tyrosine kinase activity in the nucleus of cultured adipocytes.
Journal of cellular physiology 1993;157(2):217-28.
1993: Mario J A Saad; Franco Folli; J A Kahn; C Ronald Kahn
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.
The Journal of clinical investigation 1993;92(4):2065-72.
1993: Franco Folli; Mario J A Saad; Jonathan M Backer; C Ronald Kahn
Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.
The Journal of clinical investigation 1993;92(4):1787-94.
1993: Bentley Cheatham; Steven E Shoelson; K Yamada; E Goncalves; C Ronald Kahn
Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(15):7336-40.
1993: E Araki; Xiao Jian Sun; B L Haag; L M Chuang; Y Zhang; T L Yang-Feng; Morris F White; C Ronald Kahn
Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization.
Diabetes 1993;42(7):1041-54.
1993: E Goncalves; K Yamada; Hemant S Thatte; Jonathan M Backer; David E Golan; C Ronald Kahn; Steven E Shoelson
Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(12):5762-6.
1993: L M Chuang; Martin G Myers Jr; G A Seidner; Morris J Birnbaum; Morris F White; C Ronald Kahn
Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5172-5.
1993: Edward P Feener; Jonathan M Backer; George L King; P A Wilden; Xiao Jian Sun; C Ronald Kahn; Morris F White
Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor.
The Journal of biological chemistry 1993;268(15):11256-64.
1993: Péter Csermely; Tamás Schnaider; Bentley Cheatham; M O Olson; C Ronald Kahn
Insulin induces the phosphorylation of nucleolin. A possible mechanism of insulin-induced RNA efflux from nuclei.
The Journal of biological chemistry 1993;268(13):9747-52.
1993: C Ronald Kahn; A B Goldfine
Molecular determinants of insulin action.
Journal of diabetes and its complications 1993;7(2):92-105.
1993: K M Kriauciunas; B J Goldstein; M A Lipes; C Ronald Kahn
Modulation of expression of insulin and IGF-I receptor by Epstein-Barr virus and its gene products LMP and EBNA-2 in lymphocyte cell lines.
Journal of cellular physiology 1993;154(3):486-95.
1993: C Ronald Kahn; Morris F White; Steven E Shoelson; Jonathan M Backer; E Araki; Bentley Cheatham; Péter Csermely; Franco Folli; B J Goldstein; P Huertas
The insulin receptor and its substrate: molecular determinants of early events in insulin action.
Recent progress in hormone research 1993;48():291-339.
1992: Xiao Jian Sun; M Miralpeix; Martin G Myers Jr; E M Glasheen; Jonathan M Backer; C Ronald Kahn; Morris F White
Expression and function of IRS-1 in insulin signal transmission.
The Journal of biological chemistry 1992;267(31):22662-72.
1992: Franco Folli; Mario J A Saad; Jonathan M Backer; C Ronald Kahn
Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.
The Journal of biological chemistry 1992;267(31):22171-7.
1992: Mario J A Saad; E Araki; M Miralpeix; P L Rothenberg; Morris F White; C Ronald Kahn
Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.
The Journal of clinical investigation 1992;90(5):1839-49.
1992: J Meyerovitch; Jonathan M Backer; Péter Csermely; Steven E Shoelson; C Ronald Kahn
Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells.
Biochemistry 1992;31(42):10338-44.
1992: Péter Csermely; C Ronald Kahn
Insulin induces the phosphorylation of DNA-binding nuclear proteins including lamins in 3T3-F442A.
Biochemistry 1992;31(41):9940-6.
1992: C Ronald Kahn; Mario J A Saad
Alterations in insulin receptor and substrate phosphorylation in hypertensive rats.
Journal of the American Society of Nephrology : JASN 1992;3(4 Suppl):S69-77.
1992: P A Wilden; C Ronald Kahn; K Siddle; Morris F White
Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function.
The Journal of biological chemistry 1992;267(23):16660-8.
1992: P A Wilden; K Siddle; E Haring; Jonathan M Backer; Morris F White; C Ronald Kahn
The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies.
The Journal of biological chemistry 1992;267(19):13719-27.
1992: K Yamada; E Goncalves; C Ronald Kahn; Steven E Shoelson
Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro.
The Journal of biological chemistry 1992;267(18):12452-61.
1992: Bentley Cheatham; C Ronald Kahn
Cysteine 647 in the insulin receptor is required for normal covalent interaction between alpha- and beta-subunits and signal transduction.
The Journal of biological chemistry 1992;267(10):7108-15.
1992: B J Goldstein; W R Zhang; N Hashimoto; C Ronald Kahn
Approaches to the molecular cloning of protein-tyrosine phosphatases in insulin-sensitive tissues.
Molecular and cellular biochemistry 1992;109(2):107-13.
1992: G Zoppini; C Ronald Kahn
Effect of phospholipase treatment on insulin receptor signal transduction.
Diabetologia 1992;35(2):109-15.
1992: Jonathan M Backer; G G Schroeder; C Ronald Kahn; Martin G Myers Jr; P A Wilden; D A Cahill; Morris F White
Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.
The Journal of biological chemistry 1992;267(2):1367-74.
1992: S Hauguel-DeMouzon; Péter Csermely; G Zoppini; C Ronald Kahn
Quantitative dissociation between EGF effects on c-myc and c-fos gene expression, DNA synthesis, and epidermal growth factor receptor tyrosine kinase activity.
Journal of cellular physiology 1992;150(1):180-7.
1991: Steven E Shoelson; M Boni-Schnetzler; Paul F Pilch; C Ronald Kahn
Autophosphorylation within insulin receptor beta-subunits can occur as an intramolecular process.
Biochemistry 1991;30(31):7740-6.
1991: Xiao Jian Sun; P Rothenberg; C Ronald Kahn; Jonathan M Backer; E Araki; P A Wilden; D A Cahill; B J Goldstein; Morris F White
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein.
Nature 1991;352(6330):73-7.
1991: P L Rothenberg; William Stratton Lane; A Karasik; Jonathan M Backer; M White; C Ronald Kahn
Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase.
The Journal of biological chemistry 1991;266(13):8302-11.
1991: J Meyerovitch; P Rothenberg; Yoram Shechter; Susan Bonner-Weir; C Ronald Kahn
Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1991;87(4):1286-94.
1991: Péter Csermely; C Ronald Kahn
The 90-kDa heat shock protein (hsp-90) possesses an ATP binding site and autophosphorylating activity.
The Journal of biological chemistry 1991;266(8):4943-50.
1991: Sarah Ferber; D J Gross; L Villa-Komaroff; F Danehy; F Vollenweider; K Meyer; M R Loeken; C Ronald Kahn; Philippe A Halban
Heterogeneity of expression and secretion of native and mutant [AspB10]insulin in AtT20 cells.
Molecular endocrinology (Baltimore, Md.) 1991;5(3):319-26.
1991: M Okamoto; A Karasik; Morris F White; C Ronald Kahn
Coordinate phosphorylation of insulin-receptor kinase and its 175,000-Mr endogenous substrate in rat hepatocytes.
Diabetes 1991;40(1):66-72.
1991: S Hauguel-de Mouzon; C Ronald Kahn
Insulin-like growth factor-mediated phosphorylation and protooncogene induction in Madin-Darby canine kidney cells.
Molecular endocrinology (Baltimore, Md.) 1991;5(1):51-60.
1990: M Okamoto; A Karasik; Morris F White; C Ronald Kahn
Epidermal growth factor stimulated phosphorylation of a 120-kilodalton endogenous substrate protein in rat hepatocytes.
Biochemistry 1990;29(40):9489-94.
1990: A S Edge; C Ronald Kahn; Robert Spiro
Insulin receptor carbohydrate units contain poly-N-acetyllactosamine chains.
Endocrinology 1990;127(4):1887-95.
1990: Jonathan M Backer; C Ronald Kahn; D A Cahill; A Ullrich; Morris F White
Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.
The Journal of biological chemistry 1990;265(27):16450-4.
1990: Jonathan M Backer; C Ronald Kahn; Morris F White
The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells.
The Journal of biological chemistry 1990;265(25):14828-35.
1990: A Karasik; P L Rothenberg; K Yamada; Morris F White; C Ronald Kahn
Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats.
The Journal of biological chemistry 1990;265(18):10226-31.
1990: P A Wilden; Jonathan M Backer; C Ronald Kahn; D A Cahill; G J Schroeder; Morris F White
The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3358-62.
1990: J Meyerovitch; C Ronald Kahn; Yoram Shechter
A family of polypeptide substrates and inhibitors of insulin receptor kinase.
Biochemistry 1990;29(15):3654-60.
1990: Y T Kruszynska; P A Halban; C Ronald Kahn; Morris F White
Activation of liver and muscle insulin receptor tyrosine kinase activity during in vivo insulin administration in rats.
Diabetologia 1990;33(2):77-83.
1990: A Karasik; S S Reddy; R B Pepinsky; T Brock; C Ronald Kahn
Augmented desensitization to epidermal growth factor (EGF) immediate actions: a novel mechanism for altered EGF growth response in mutant A431 cells.
Journal of cellular physiology 1990;142(2):231-5.
1989: S S Reddy; C Ronald Kahn
Epidermal growth factor receptor defects in leprechaunism. A multiple growth factor-resistant syndrome.
The Journal of clinical investigation 1989;84(5):1569-76.
1989: D G Hurrell; O Pedersen; C Ronald Kahn
Alterations in the hepatic insulin receptor kinase in genetic and acquired obesity in rats.
Endocrinology 1989;125(5):2454-62.
1989: C Ronald Kahn
Perverted priorities. The physician/scientist as spokesman and salesman for biomedical research. Presidential address to the American Society for Clinical Investigation, Washington, DC, 29 April 1989.
The Journal of clinical investigation 1989;84(3):723-7.
1989: J Meyerovitch; Jonathan M Backer; C Ronald Kahn
Hepatic phosphotyrosine phosphatase activity and its alterations in diabetic rats.
The Journal of clinical investigation 1989;84(3):976-83.
1989: S S Reddy; Dirk Müller-Wieland; K Kriauciunas; C Ronald Kahn
Molecular defects in the insulin receptor in patients with leprechaunism and in their parents.
The Journal of laboratory and clinical medicine 1989;114(2):165-70.
1989: B J Goldstein; C Ronald Kahn
Insulin receptor messenger ribonucleic acid sequence alterations detected by ribonuclease cleavage in patients with syndromes of insulin resistance.
The Journal of clinical endocrinology and metabolism 1989;69(1):15-24.
1989: R Perlman; Donald Bottaro; Morris F White; C Ronald Kahn
Conformational changes in the alpha- and beta-subunits of the insulin receptor identified by anti-peptide antibodies.
The Journal of biological chemistry 1989;264(15):8946-50.
1989: Steven E Shoelson; Morris F White; C Ronald Kahn
Nonphosphorylatable substrate analogs selectively block autophosphorylation and activation of the insulin receptor, epidermal growth factor receptor, and pp60v-src kinases.
The Journal of biological chemistry 1989;264(14):7831-6.
1989: C Ronald Kahn; V Lauris; S Koch; M Crettaz; D K Granner
Acute and chronic regulation of phosphoenolpyruvate carboxykinase mRNA by insulin and glucose.
Molecular endocrinology (Baltimore, Md.) 1989;3(5):840-5.
1989: Jonathan M Backer; C Ronald Kahn; Morris F White
Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3209-13.
1989: Morris F White; C Ronald Kahn
Cascade of autophosphorylation in the beta-subunit of the insulin receptor.
Journal of cellular biochemistry 1989;39(4):429-41.
1989: B J Goldstein; C Ronald Kahn
Analysis of mRNA heterogeneity by ribonuclease H mapping: application to the insulin receptor.
Biochemical and biophysical research communications 1989;159(2):664-9.
1989: Nancy J Cox; Richard S Spielman; C Ronald Kahn; Dirk Müller-Wieland; K M Kriauciunas; Rebecca Taub
Four RFLPs of the human insulin receptor gene: PstI, KpnI, RsaI (2 RFLPs).
Nucleic acids research 1989;17(2):820.
1989: Jonathan M Backer; C Ronald Kahn; Morris F White
Tyrosine phosphorylation of the insulin receptor during insulin-stimulated internalization in rat hepatoma cells.
The Journal of biological chemistry 1989;264(3):1694-701.
1989: C F Kwok; B J Goldstein; Dirk Müller-Wieland; T S Lee; C Ronald Kahn; George L King
Identification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats.
The Journal of clinical investigation 1989;83(1):127-36.
1989: Dirk Müller-Wieland; Rebecca Taub; D S Tewari; K M Kriauciunas; S Sethu; K Reddy; C Ronald Kahn
Insulin-receptor gene and its expression in patients with insulin resistance.
Diabetes 1989;38(1):31-8.
1988: A Karasik; R B Pepinsky; C Ronald Kahn
Insulin and epidermal growth factor stimulate phosphorylation of a 170-kDa protein in intact hepatocytes immunologically related to lipocortin 1.
The Journal of biological chemistry 1988;263(34):18558-62.
1988: K M Kriauciunas; C Ronald Kahn; Dirk Müller-Wieland; S S Reddy; Rebecca Taub
Altered expression and function of the insulin receptor in a family with lipoatrophic diabetes.
The Journal of clinical endocrinology and metabolism 1988;67(6):1284-93.
1988: A Karasik; C Ronald Kahn
Dexamethasone-induced changes in phosphorylation of the insulin and epidermal growth factor receptors and their substrates in intact rat hepatocytes.
Endocrinology 1988;123(5):2214-22.
1988: P L Rothenberg; C Ronald Kahn
Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins.
The Journal of biological chemistry 1988;263(30):15546-52.
1988: James H Warram; Andrzej S Krolewski; C Ronald Kahn
Determinants of IDDM and perinatal mortality in children of diabetic mothers.
Diabetes 1988;37(10):1328-34.
1988: S S Reddy; V Lauris; C Ronald Kahn
Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization.
The Journal of clinical investigation 1988;82(4):1359-65.
1988: C Ronald Kahn; Morris F White
The insulin receptor and the molecular mechanism of insulin action.
The Journal of clinical investigation 1988;82(4):1151-6.
1988: S S Reddy; C Ronald Kahn
Insulin resistance: a look at the role of insulin receptor kinase.
Diabetic medicine : a journal of the British Diabetic Association 1988;5(7):621-9.
1988: B J Goldstein; C Ronald Kahn
Initial processing of the insulin receptor precursor in vivo and in vitro.
The Journal of biological chemistry 1988;263(26):12809-12.
1988: Morris F White; J N Livingston; Jonathan M Backer; V Lauris; T J Dull; A Ullrich; C Ronald Kahn
Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity.
Cell 1988;54(5):641-9.
1988: Nancy J Cox; Richard S Spielman; C Ronald Kahn; Dirk Müller-Wieland; K M Kriauciunas; Rebecca Taub
Four RFLPs of the human insulin receptor gene: PstI, KpnI, RsaI (2 RFLPs).
Nucleic acids research 1988;16(16):8204.
1988: A Karasik; R Blake Pepinsky; Steven E Shoelson; C Ronald Kahn
Lipocortins 1 and 2 as substrates for the insulin receptor kinase in rat liver.
The Journal of biological chemistry 1988;263(24):11862-7.
1988: S Ludwig; Dirk Müller-Wieland; B J Goldstein; C Ronald Kahn
The insulin receptor gene and its expression in insulin-resistant mice.
Endocrinology 1988;123(1):594-600.
1988: S Takayama; C Ronald Kahn; K Kubo; J E Foley
Alterations in insulin receptor autophosphorylation in insulin resistance: correlation with altered sensitivity to glucose transport and antilipolysis to insulin.
The Journal of clinical endocrinology and metabolism 1988;66(5):992-9.
1988: Steven E Shoelson; Morris F White; C Ronald Kahn
Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control.
The Journal of biological chemistry 1988;263(10):4852-60.
1988: M Okamoto; C Ronald Kahn; R Maron; Morris F White
Decreased autophosphorylation of EGF receptor in insulin-deficient diabetic rats.
The American journal of physiology 1988;254(4 Pt 1):E429-34.
1988: S Takayama; Morris F White; C Ronald Kahn
Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.
The Journal of biological chemistry 1988;263(7):3440-7.
1988: Morris F White; Steven E Shoelson; H Keutmann; C Ronald Kahn
A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.
The Journal of biological chemistry 1988;263(6):2969-80.
1988: M Crettaz; Dirk Müller-Wieland; C Ronald Kahn
Transcriptional and posttranscriptional regulation of tyrosine aminotransferase by insulin in rat hepatoma cells.
Biochemistry 1988;27(1):495-500.
1987: B J Goldstein; Dirk Müller-Wieland; C Ronald Kahn
Variation in insulin receptor messenger ribonucleic acid expression in human and rodent tissues.
Molecular endocrinology (Baltimore, Md.) 1987;1(11):759-66.
1987: A Karasik; C Ronald Kahn
Antibodies to the insulin receptor as tools in the study of receptor structure and function.
Annals of the New York Academy of Sciences 1987;505():301-12.
1986: V Lauris; M Crettaz; C Ronald Kahn
Coordinate roles of insulin and glucose on the growth of hepatoma cells in culture.
Endocrinology 1986;118(6):2519-24.
1985: V L Herzberg; FLORIN GRIGORESCU; A S Edge; Robert Spiro; C Ronald Kahn
Characterization of insulin receptor carbohydrate by comparison of chemical and enzymatic deglycosylation.
Biochemical and biophysical research communications 1985;129(3):789-96.
1983: M Fehlmann; M Crettaz; C Ronald Kahn
Glucagon resistance of hepatoma cells. Evidence for receptor and post-receptor defects.
The Biochemical journal 1983;214(3):845-50.
1983: C Ronald Kahn; V Lauris; M Fehlmann; M Crettaz
Expression of insulin receptors and insulin action in cell hybrids and cybrids.
The Biochemical journal 1983;214(2):309-16.
1983: M Crettaz; C Ronald Kahn; M Fehlmann
Glucagon regulation of amino acid transport in hepatocytes: effect of cell enucleation.
Journal of cellular physiology 1983;115(2):186-90.