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Ronald Kahn

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

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Ikeda Hiroyuki; Shiojima Ichiro; Ozasa Yukako; Yoshida Masashi; Holzenberger Martin; Kahn C Ronald; Walsh Kenneth; Igarashi Takashi; Abel E Dale; Komuro Issei
Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.
Wang Xiaohui L; Suzuki Ryo; Lee Kevin; Tran Thien; Gunton Jenny E; Saha Asish K; Patti Mary-Elizabeth; Goldfine Allison; Ruderman Neil B; Gonzalez Frank J; Kahn C Ronald
Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones.
Cypess Aaron M; Lehman Sanaz; Williams Gethin; Tal Ilan; Rodman Dean; Goldfine Allison B; Kuo Frank C; Palmer Edwin L; Tseng Yu-Hua; Doria Alessandro; Kolodny Gerald M; Kahn C Ronald
Identification and importance of brown adipose tissue in adult humans.

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All Publications

2009: Ikeda Hiroyuki; Shiojima Ichiro; Ozasa Yukako; Yoshida Masashi; Holzenberger Martin; Kahn C Ronald; Walsh Kenneth; Igarashi Takashi; Abel E Dale; Komuro Issei
Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.
Journal of molecular and cellular cardiology 2009;47(5):664-75.
2009: Wang Xiaohui L; Suzuki Ryo; Lee Kevin; Tran Thien; Gunton Jenny E; Saha Asish K; Patti Mary-Elizabeth; Goldfine Allison; Ruderman Neil B; Gonzalez Frank J; Kahn C Ronald
Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones.
Cell metabolism 2009;9(5):428-39.
2009: Cypess Aaron M; Lehman Sanaz; Williams Gethin; Tal Ilan; Rodman Dean; Goldfine Allison B; Kuo Frank C; Palmer Edwin L; Tseng Yu-Hua; Doria Alessandro; Kolodny Gerald M; Kahn C Ronald
Identification and importance of brown adipose tissue in adult humans.
The New England journal of medicine 2009;360(15):1509-17.
2008: Norris Andrew W; Hirshman Michael F; Yao Jianrong; Jessen Niels; Musi Nicolas; Chen Lihong; Sivitz William I; Goodyear Laurie J; Kahn C Ronald
Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle.
Endocrinology 2008;149(11):5374-83.
2008: Kahn C Ronald
Medicine. Can we nip obesity in its vascular bud?
Science (New York, N.Y.) 2008;322(5901):542-3.
2008: Doria Alessandro; Patti Mary-Elizabeth; Kahn C Ronald
The emerging genetic architecture of type 2 diabetes.
Cell metabolism 2008;8(3):186-200.
2008: Tseng Yu-Hua; Kokkotou Efi; Schulz Tim J; Huang Tian Lian; Winnay Jonathon N; Taniguchi Cullen M; Tran T Thien; Suzuki Ryo; Espinoza Daniel O; Yamamoto Yuji; Ahrens Molly J; Dudley Andrew T; Norris Andrew W; Kulkarni Rohit N; Kahn C Ronald
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.
Nature 2008;454(7207):1000-4.
2008: Biddinger Sudha B; Haas Joel T; Yu Bian B; Bezy Olivier; Jing Enxuan; Zhang Wenwei; Unterman Terry G; Carey Martin C; Kahn C Ronald
Hepatic insulin resistance directly promotes formation of cholesterol gallstones.
Nature medicine 2008;14(7):778-82.
2008: Rajala Ammaji; Tanito Masaki; Le Yun Z; Kahn C Ronald; Rajala Raju V S
Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells.
The Journal of biological chemistry 2008;283(28):19781-92.
2008: Koch Linda; Wunderlich F Thomas; Seibler Jost; Könner A Christine; Hampel Brigitte; Irlenbusch Sigrid; Brabant Georg; Kahn C Ronald; Schwenk Frieder; Brüning Jens C
Central insulin action regulates peripheral glucose and fat metabolism in mice.
The Journal of clinical investigation 2008;118(6):2132-47.
2008: Tran Thien T; Yamamoto Yuji; Gesta Stephane; Kahn C Ronald
Beneficial effects of subcutaneous fat transplantation on metabolism.
Cell metabolism 2008;7(5):410-20.
2008: Tiwari Swasti; Sharma Nikhil; Gill Pritmohinder S; Igarashi Peter; Kahn C Ronald; Wade James B; Ecelbarger Carolyn M A
Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(17):6469-74.
2008: Emanuelli Brice; Eberlé Delphine; Suzuki Ryo; Kahn C Ronald
Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3545-50.
2008: Krüger Marcus; Kratchmarova Irina; Blagoev Blagoy; Tseng Yu-Hua; Kahn C Ronald; Mann Matthias
Dissection of the insulin signaling pathway via quantitative phosphoproteomics.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2451-6.
2008: Biddinger Sudha B; Hernandez-Ono Antonio; Rask-Madsen Christian; Haas Joel T; Alemán José O; Suzuki Ryo; Scapa Erez F; Agarwal Chhavi; Carey Martin C; Stephanopoulos Gregory; Cohen David E; King George L; Ginsberg Henry N; Kahn C Ronald
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.
Cell metabolism 2008;7(2):125-34.
2007: Chang Lin; Zhang Jifeng; Tseng Yu-Hua; Xie Chang-Qing; Ilany Jacob; Brüning Jens C; Sun Zhongcui; Zhu Xiaojun; Cui Taixing; Youker Keith A; Yang Qinglin; Day Sharlene M; Kahn C Ronald; Chen Y Eugene
Rad GTPase deficiency leads to cardiac hypertrophy.
Circulation 2007;116(25):2976-83.
2007: Page Kathleen A; Dejardin Stephanie; Kahn C Ronald; Kulkarni Rohit N; Herold Kevan C; Inzucchi Silvio E
A patient with type B insulin resistance syndrome, responsive to immune therapy.
Nature clinical practice. Endocrinology & metabolism 2007;3(12):835-40.
2007: Katic Masa; Kennedy Adam R; Leykin Igor; Norris Andrew; McGettrick Aileen; Gesta Stephane; Russell Steven J; Bluher Matthias; Maratos-Flier Eleftheria; Kahn C Ronald
Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice.
Aging cell 2007;6(6):827-39.
2007: Murata Yusuke; Tsuruzoe Kaku; Kawashima Junji; Furukawa Noboru; Kondo Tatsuya; Motoshima Hiroyuki; Igata Motoyuki; Taketa Kayo; Sasaki Kazunari; Kishikawa Hideki; Kahn C Ronald; Toyonaga Tetsushi; Araki Eiichi
IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance.
Biochemical and biophysical research communications 2007;364(2):301-7.
2007: Pospisilik J Andrew; Knauf Claude; Joza Nicholas; Benit Paule; Orthofer Michael; Cani Patrice D; Ebersberger Ingo; Nakashima Tomoki; Sarao Renu; Neely Gregory; Esterbauer Harald; Kozlov Andrey; Kahn C Ronald; Kroemer Guido; Rustin Pierre; Burcelin Remy; Penninger Josef M
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes.
Cell 2007;131(3):476-91.
2007: Fink Brian D; Herlein Judy A; Almind Katrine; Cinti Saverio; Kahn C Ronald; Sivitz William I
Mitochondrial proton leak in obesity-resistant and obesity-prone mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(5):R1773-80.
2007: Gesta Stephane; Tseng Yu-Hua; Kahn C Ronald
Developmental origin of fat: tracking obesity to its source.
Cell 2007;131(2):242-56.
2007: Bezy Olivier; Vernochet Cecile; Gesta Stephane; Farmer Stephen R; Kahn C Ronald
TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity.
Molecular and cellular biology 2007;27(19):6818-31.
2007: Russell Steven J; Kahn C Ronald
Endocrine regulation of ageing.
Nature reviews. Molecular cell biology 2007;8(9):681-91.
2007: Jing Enxuan; Gesta Stephane; Kahn C Ronald
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.
Cell metabolism 2007;6(2):105-14.
2007: Farese Robert V; Sajan Mini P; Yang Hong; Li Pengfei; Mastorides Steven; Gower William R; Nimal Sonali; Choi Cheol Soo; Kim Sheene; Shulman Gerald I; Kahn C Ronald; Braun Ursula; Leitges Michael
Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.
The Journal of clinical investigation 2007;117(8):2289-301.
2007: Cohen Shmuel E; Kokkotou Efi; Biddinger Sudha B; Kondo Tatsuya; Gebhardt Rolf; Kratzsch Juergen; Mantzoros Christos S; Kahn C Ronald
High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice.
The Journal of biological chemistry 2007;282(32):23672-8.
2007: Xue Bingzhong; Kim Young-Bum; Lee Anna; Toschi Elena; Bonner-Weir Susan; Kahn C Ronald; Neel Benjamin G; Kahn Barbara B
Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
The Journal of biological chemistry 2007;282(33):23829-40.
2007: Mouche Sarah; Mkaddem Sanae Ben; Wang Wei; Katic Masa; Tseng Yu-Hua; Carnesecchi Stephanie; Steger Klaus; Foti Michelangelo; Meier Christoph A; Muzzin Patrick; Kahn C Ronald; Ogier-Denis Eric; Szanto Ildiko
Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation.
Biochimica et biophysica acta 2007;1773(7):1015-27.
2007: Könner A Christine; Janoschek Ruth; Plum Leona; Jordan Sabine D; Rother Eva; Ma Xiaosong; Xu Chun; Enriori Pablo; Hampel Brigitte; Barsh Gregory S; Kahn C Ronald; Cowley Michael A; Ashcroft Frances M; Brüning Jens C
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.
Cell metabolism 2007;5(6):438-49.
2007: Kulkarni Rohit N; Kahn C Ronald
Ephs and ephrins keep pancreatic Beta cells connected.
Cell 2007;129(2):241-3.
2007: Taniguchi Cullen M; Aleman José O; Ueki Kohjiro; Luo Ji; Asano Tomoichiro; Kaneto Hideaki; Stephanopoulos Gregory; Cantley Lewis C; Kahn C Ronald
The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
Molecular and cellular biology 2007;27(8):2830-40.
2007: Laustsen Palle G; Russell Steven J; Cui Lei; Entingh-Pearsall Amelia; Holzenberger Martin; Liao Ronglih; Kahn C Ronald
Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function.
Molecular and cellular biology 2007;27(5):1649-64.
2007: Almind Katrine; Manieri Monia; Sivitz William I; Cinti Saverio; Kahn C Ronald
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2366-71.
2006: Koh Ho-Jin; Arnolds David E; Fujii Nobuharu; Tran Thien T; Rogers Marc J; Jessen Niels; Li Yangfeng; Liew Chong Wee; Ho Richard C; Hirshman Michael F; Kulkarni Rohit N; Kahn C Ronald; Goodyear Laurie J
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.
Molecular and cellular biology 2006;26(22):8217-27.
2006: Taniguchi Cullen M; Tran Thien T; Kondo Tatsuya; Luo Ji; Ueki Kohjiro; Cantley Lewis C; Kahn C Ronald
Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):12093-7.
2006: Biddinger Sudha B; Miyazaki Makoto; Boucher Jeremie; Ntambi James M; Kahn C Ronald
Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c.
Diabetes 2006;55(7):2032-41.
2006: Taniguchi Cullen M; Kondo Tatsuya; Sajan Mini; Luo Ji; Bronson Roderick; Asano Tomoichiro; Farese Robert; Cantley Lewis C; Kahn C Ronald
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.
Cell metabolism 2006;3(5):343-53.
2006: Ueki Kohjiro; Okada Terumasa; Hu Jiang; Liew Chong Wee; Assmann Anke; Dahlgren Gabriella M; Peters Jennifer L; Shackman Jonathan G; Zhang Min; Artner Isabella; Satin Leslie S; Stein Roland; Holzenberger Martin; Kennedy Robert T; Kahn C Ronald; Kulkarni Rohit N
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.
Nature genetics 2006;38(5):583-8.
2006: Gesta Stephane; Blüher Matthias; Yamamoto Yuji; Norris Andrew W; Berndt Janin; Kralisch Susan; Boucher Jeremie; Lewis Choy; Kahn C Ronald
Evidence for a role of developmental genes in the origin of obesity and body fat distribution.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(17):6676-81.
2006: Inoue Hiroshi; Ogawa Wataru; Asakawa Akihiro; Okamoto Yasuo; Nishizawa Akihiko; Matsumoto Michihiro; Teshigawara Kiyoshi; Matsuki Yasushi; Watanabe Eijiro; Hiramatsu Ryuji; Notohara Kenji; Katayose Koji; Okamura Hitoshi; Kahn C Ronald; Noda Tetsuo; Takeda Kiyoshi; Akira Shizuo; Inui Akio; Kasuga Masato
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.
Cell metabolism 2006;3(4):267-75.
2006: Baumgartl Julia; Baudler Stephanie; Scherner Maximilian; Babaev Vladimir; Makowski Liza; Suttles Jill; McDuffie Marcia; Tobe Kazuyuki; Kadowaki Takashi; Fazio Sergio; Kahn C Ronald; Hotamisligil Gökhan S; Krone Wilhelm; Linton Macrae; Brüning Jens C
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.
Cell metabolism 2006;3(4):247-56.
2006: He Zhiheng; Opland Darren M; Way Kerrie J; Ueki Kohjiro; Bodyak Natalya; Kang Peter M; Izumo Seigo; Kulkarni Rohit N; Wang Bo; Liao Ronglih; Kahn C Ronald; King George L
Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):787-93.
2006: Ilany Jacob; Bilan Philip J; Kapur Sonia; Caldwell James S; Patti Mary-Elizabeth; Marette Andre; Kahn C Ronald
Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4481-6.
2006: Taniguchi Cullen M; Emanuelli Brice; Kahn C Ronald
Critical nodes in signalling pathways: insights into insulin action.
Nature reviews. Molecular cell biology 2006;7(2):85-96.
2006: Norris Andrew W; Kahn C Ronald
Analysis of gene expression in pathophysiological states: balancing false discovery and false negative rates.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(3):649-53.
2006: Biddinger Sudha B; Kahn C Ronald
From mice to men: insights into the insulin resistance syndromes.
Annual review of physiology 2006;68():123-58.
2005: Knauf Claude; Cani Patrice D; Perrin Christophe; Iglesias Miguel A; Maury Jean François; Bernard Elodie; Benhamed Fadilha; Grémeaux Thierry; Drucker Daniel J; Kahn C Ronald; Girard Jean; Tanti Jean François; Delzenne Nathalie M; Postic Catherine; Burcelin Rémy
Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage.
The Journal of clinical investigation 2005;115(12):3554-63.
2005: Kim Young-Bum; Peroni Odile D; Aschenbach William G; Minokoshi Yasuhiko; Kotani Ko; Zisman Ariel; Kahn C Ronald; Goodyear Laurie J; Kahn Barbara B
Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism.
Molecular and cellular biology 2005;25(21):9713-23.
2005: Barbour Linda A; Mizanoor Rahman Shaikh; Gurevich Inga; Leitner J Wayne; Fischer Stephanie J; Roper Michael D; Knotts Trina A; Vo Yen; McCurdy Carrie E; Yakar Shoshana; Leroith Derek; Kahn C Ronald; Cantley Lewis C; Friedman Jacob E; Draznin Boris
Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.
The Journal of biological chemistry 2005;280(45):37489-94.
2005: Ueki Kohjiro; Kadowaki Takashi; Kahn C Ronald
Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome.
Hepatology research : the official journal of the Japan Society of Hepatology 2005;33(2):185-92.
2005: Kurosu Hiroshi; Yamamoto Masaya; Clark Jeremy D; Pastor Johanne V; Nandi Animesh; Gurnani Prem; McGuinness Owen P; Chikuda Hirotaka; Yamaguchi Masayuki; Kawaguchi Hiroshi; Shimomura Iichiro; Takayama Yoshiharu; Herz Joachim; Kahn C Ronald; Rosenblatt Kevin P; Kuro-o Makoto
Suppression of aging in mice by the hormone Klotho.
Science (New York, N.Y.) 2005;309(5742):1829-33.
2005: Gunton Jenny E; Kulkarni Rohit N; Yim SunHee; Okada Terumasa; Hawthorne Wayne J; Tseng Yu-Hua; Roberson Russell S; Ricordi Camillo; O'Connell Philip J; Gonzalez Frank J; Kahn C Ronald
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.
Cell 2005;122(3):337-49.
2005: Tseng Yu-Hua; Butte Atul J; Kokkotou Efi; Yechoor Vijay K; Taniguchi Cullen M; Kriauciunas Kristina M; Cypess Aaron M; Niinobe Michio; Yoshikawa Kazuaki; Patti Mary Elizabeth; Kahn C Ronald
Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin.
Nature cell biology 2005;7(6):601-11.
2005: Fisher Simon J; Brüning Jens C; Lannon Scott; Kahn C Ronald
Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia.
Diabetes 2005;54(5):1447-51.
2005: Biddinger Sudha B; Almind Katrine; Miyazaki Makoto; Kokkotou Efi; Ntambi James M; Kahn C Ronald
Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome.
Diabetes 2005;54(5):1314-23.
2005: Fu Mingui; Zhang Jifeng; Tseng Yu-Hua; Cui Taixing; Zhu Xiaojun; Xiao Yan; Mou Yongshan; De Leon Hector; Chang Mary M J; Hamamori Yasuo; Kahn C Ronald; Chen Yuqing E
Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration.
Circulation 2005;111(8):1071-7.
2005: Wijesekara Nadeeja; Konrad Daniel; Eweida Mohamed; Jefferies Craig; Liadis Nicole; Giacca Adria; Crackower Mike; Suzuki Akira; Mak Tak W; Kahn C Ronald; Klip Amira; Woo Minna
Muscle-specific Pten deletion protects against insulin resistance and diabetes.
Molecular and cellular biology 2005;25(3):1135-45.
2005: McGettrick Aileen J; Feener Edward P; Kahn C Ronald
Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation.
The Journal of biological chemistry 2005;280(8):6441-6.
2005: Ehrenkranz Joel R L; Lewis Norman G; Kahn C Ronald; Roth Jesse
Phlorizin: a review.
Diabetes/metabolism research and reviews 2005;21(1):31-8.
2004: Miura Atsushi; Sajan Mini P; Standaert Mary L; Bandyopadhyay Gautam; Kahn C Ronald; Farese Robert V
Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes.
Biochemistry 2004;43(49):15503-9.
2004: Almind Katrine; Kahn C Ronald
Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice.
Diabetes 2004;53(12):3274-85.
2004: Yechoor Vijay K; Patti Mary-Elizabeth; Ueki Kohjiro; Laustsen Palle G; Saccone Robert; Rauniyar Ravi; Kahn C Ronald
Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16525-30.
2004: Kahn C Ronald; Roth Jesse
Berson, Yalow, and the JCI: the agony and the ecstasy.
The Journal of clinical investigation 2004;114(8):1051-4.
2004: Bouché Clara; Serdy Shanti; Kahn C Ronald; Goldfine Allison B
The cellular fate of glucose and its relevance in type 2 diabetes.
Endocrine reviews 2004;25(5):807-30.
2004: Mason Steven D; Howlett Richard A; Kim Matthew J; Olfert I Mark; Hogan Michael C; McNulty Wayne; Hickey Reed P; Wagner Peter D; Kahn C Ronald; Giordano Frank J; Johnson Randall S
Loss of skeletal muscle HIF-1alpha results in altered exercise endurance.
PLoS biology 2004;2(10):e288.
2004: Kulkarni Rohit N; Jhala Ulupi S; Winnay Jonathon N; Krajewski Stan; Montminy Marc; Kahn C Ronald
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance.
The Journal of clinical investigation 2004;114(6):828-36.
2004: Entingh-Pearsall Amelia; Kahn C Ronald
Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I.
The Journal of biological chemistry 2004;279(36):38016-24.
2004: Kondo Tatsuya; Kahn C Ronald
Altered insulin signaling in retinal tissue in diabetic states.
The Journal of biological chemistry 2004;279(36):37997-8006.
2004: Ueki Kohjiro; Kondo Tatsuya; Tseng Yu-Hua; Kahn C Ronald
Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(28):10422-7.
2004: Blüher Matthias; Wilson-Fritch Leanne; Leszyk John; Laustsen Palle G; Corvera Silvia; Kahn C Ronald
Role of insulin action and cell size on protein expression patterns in adipocytes.
The Journal of biological chemistry 2004;279(30):31902-9.
2004: Blüher Matthias; Patti Mary-Elizabeth; Gesta Stephane; Kahn Barbara B; Kahn C Ronald
Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression.
The Journal of biological chemistry 2004;279(30):31891-901.
2004: Goren H Joseph; Kulkarni Rohit N; Kahn C Ronald
Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1.
Endocrinology 2004;145(7):3307-23.
2004: Ueki Kohjiro; Kondo Tatsuya; Kahn C Ronald
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms.
Molecular and cellular biology 2004;24(12):5434-46.
2004: Kondo Tatsuya; Hafezi-Moghadam Ali; Thomas Kennard; Wagner Denisa D; Kahn C Ronald
Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier.
Biochemical and biophysical research communications 2004;317(2):315-20.
2004: Nandi Anindita; Kitamura Yukari; Kahn C Ronald; Accili Domenico
Mouse models of insulin resistance.
Physiological reviews 2004;84(2):623-47.
2004: Cariou Bertrand; Postic Catherine; Boudou Philippe; Burcelin Rémy; Kahn C Ronald; Girard Jean; Burnol Anne-Françoise; Mauvais-Jarvis Franck
Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice.
Endocrinology 2004;145(4):1926-32.
2004: Schubert Markus; Gautam Dinesh; Surjo David; Ueki Kojihiko; Baudler Stephanie; Schubert Dominic; Kondo Tatsuya; Alber Jens; Galldiks Norbert; Küstermann Eckehardt; Arndt Saskia; Jacobs Andreas H; Krone Wilhelm; Kahn C Ronald; Brüning Jens C
Role for neuronal insulin resistance in neurodegenerative diseases.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3100-5.
2004: Tseng Yu-Hua; Kriauciunas Kristina M; Kokkotou Efi; Kahn C Ronald
Differential roles of insulin receptor substrates in brown adipocyte differentiation.
Molecular and cellular biology 2004;24(5):1918-29.
2004: Cohen S E; Tseng Y-H; Michael M D; Kahn C R
Effects of insulin-sensitising agents in mice with hepatic insulin resistance.
Diabetologia 2004;47(3):407-11.
2004: Kulkarni Rohit N; Kahn C Ronald
Molecular biology. HNFs--linking the liver and pancreatic islets in diabetes.
Science (New York, N.Y.) 2004;303(5662):1311-2.
2004: Asilmaz Esra; Cohen Paul; Miyazaki Makoto; Dobrzyn Pawel; Ueki Kohjiro; Fayzikhodjaeva Gulnorakhon; Soukas Alexander A; Kahn C Ronald; Ntambi James M; Socci Nicholas D; Friedman Jeffrey M
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy.
The Journal of clinical investigation 2004;113(3):414-24.
2004: Kitamura Tadahiro; Kitamura Yukari; Nakae Jun; Giordano Antonio; Cinti Saverio; Kahn C Ronald; Efstratiadis Argiris; Accili Domenico
Mosaic analysis of insulin receptor function.
The Journal of clinical investigation 2004;113(2):209-19.
2004: Chen Dong; Mauvais-Jarvis Franck; Bluher Matthias; Fisher Simon J; Jozsi Alison; Goodyear Laurie J; Ueki Kohjiro; Kahn C Ronald
p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity.
Molecular and cellular biology 2004;24(1):320-9.
2004: Otani Kenichi; Kulkarni Rohit N; Baldwin Aaron C; Krutzfeldt Jan; Ueki Kohjiro; Stoffel Markus; Kahn C Ronald; Polonsky Kenneth S
Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice.
American journal of physiology. Endocrinology and metabolism 2004;286(1):E41-9.
2003: Goldfine Allison B; Kahn C Ronald
Adiponectin: linking the fat cell to insulin sensitivity.
Lancet 2003;362(9394):1431-2.
2003: Hirashima Y; Tsuruzoe K; Kodama S; Igata M; Toyonaga T; Ueki K; Kahn C R; Araki E
Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway.
The Journal of endocrinology 2003;179(2):253-66.
2003: Ueki Kohjiro; Fruman David A; Yballe Claudine M; Fasshauer Mathias; Klein Johannes; Asano Tomoichiro; Cantley Lewis C; Kahn C Ronald
Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling.
The Journal of biological chemistry 2003;278(48):48453-66.
2003: Rosen Evan D; Kulkarni Rohit N; Sarraf Pasha; Ozcan Umut; Okada Terumasa; Hsu Chung-Hsin; Eisenman Daniel; Magnuson Mark A; Gonzalez Frank J; Kahn C Ronald; Spiegelman Bruce M
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis.
Molecular and cellular biology 2003;23(20):7222-9.
2003: Tai Yu-Tzu; Podar Klaus; Catley Laurence; Tseng Yu-Hua; Akiyama Masaharu; Shringarpure Reshma; Burger Renate; Hideshima Teru; Chauhan Dharminder; Mitsiades Nicholas; Richardson Paul; Munshi Nikhil C; Kahn C Ronald; Mitsiades Constantine; Anderson Kenneth C
Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.
Cancer research 2003;63(18):5850-8.
2003: Mora Alfonso; Davies Anthony M; Bertrand Luc; Sharif Isam; Budas Grant R; Jovanovic Sofija; Mouton Véronique; Kahn C Ronald; Lucocq John M; Gray Gillian A; Jovanovic Aleksandar; Alessi Dario R
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia.
The EMBO journal 2003;22(18):4666-76.
2003: Minokoshi Yasuhiko; Kahn C Ronald; Kahn Barbara B
Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis.
The Journal of biological chemistry 2003;278(36):33609-12.
2003: Norris Andrew W; Chen Lihong; Fisher Simon J; Szanto Ildiko; Ristow Michael; Jozsi Alison C; Hirshman Michael F; Rosen Evan D; Goodyear Laurie J; Gonzalez Frank J; Spiegelman Bruce M; Kahn C Ronald
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.
The Journal of clinical investigation 2003;112(4):608-18.
2003: Wolfrum Christian; Shih David Q; Kuwajima Satoru; Norris Andrew W; Kahn C Ronald; Stoffel Markus
Role of Foxa-2 in adipocyte metabolism and differentiation.
The Journal of clinical investigation 2003;112(3):345-56.
2003: Entingh Amelia J; Taniguchi Cullen M; Kahn C Ronald
Bi-directional regulation of brown fat adipogenesis by the insulin receptor.
The Journal of biological chemistry 2003;278(35):33377-83.
2003: Jiang Zhen Y; He Zhiheng; King Benjamin L; Kuroki Tatsuya; Opland Darren M; Suzuma Kiyoshi; Suzuma Izumi; Ueki Kohjiro; Kulkarni Rohit N; Kahn C Ronald; King George L
Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis.
The Journal of biological chemistry 2003;278(34):31964-71.
2003: Kahn C Ronald
Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes.
Experimental diabesity research 2003;4(3):169-82.
2003: Patti Mary Elizabeth; Butte Atul J; Crunkhorn Sarah; Cusi Kenneth; Berria Rachele; Kashyap Sangeeta; Miyazaki Yoshinori; Kohane Isaac; Costello Maura; Saccone Robert; Landaker Edwin J; Goldfine Allison B; Mun Edward; DeFronzo Ralph; Finlayson Jean; Kahn C Ronald; Mandarino Lawrence J
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8466-71.
2003: Kondo Tatsuya; Vicent David; Suzuma Kiyoshi; Yanagisawa Masashi; King George L; Holzenberger Martin; Kahn C Ronald
Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.
The Journal of clinical investigation 2003;111(12):1835-42.
2003: Magré Jocelyne; Delépine Marc; Van Maldergem Lionel; Robert Jean-Jacques; Maassen J Antonie; Meier Muriel; Panz Vanessa R; Kim Chong Ae; Tubiana-Rufi Nadia; Czernichow Paul; Seemanova Eva; Buchanan Charles R; Lacombe Didier; Vigouroux Corinne; Lascols Olivier; Kahn C Ronald; Capeau Jacqueline; Lathrop Mark
Prevalence of mutations in AGPAT2 among human lipodystrophies.
Diabetes 2003;52(6):1573-8.
2003: Almind Katrine; Kulkarni Rohit N; Lannon Scott M; Kahn C Ronald
Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance.
Diabetes 2003;52(6):1535-43.
2003: Kulkarni Rohit N; Almind Katrine; Goren H Joseph; Winnay Jonathon N; Ueki Kohjiro; Okada Terumasa; Kahn C Ronald
Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice.
Diabetes 2003;52(6):1528-34.
2003: Burcelin Rémy; Crivelli Valerie; Perrin Christophe; Da Costa Anabela; Mu James; Kahn Barbara B; Birnbaum Morris J; Kahn C Ronald; Vollenweider Peter; Thorens Bernard
GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization.
The Journal of clinical investigation 2003;111(10):1555-62.
2003: Vicent David; Ilany Jacob; Kondo Tatsuya; Naruse Keiko; Fisher Simon J; Kisanuki Yaz Y; Bursell Sven; Yanagisawa Masashi; King George L; Kahn C Ronald
The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance.
The Journal of clinical investigation 2003;111(9):1373-80.
2003: Goldfine Allison B; Bouche Clara; Parker Robert A; Kim Caroline; Kerivan Amy; Soeldner J Stuart; Martin Blaise C; Warram James H; Kahn C Ronald
Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2724-9.
2003: Valverde Angela M; Arribas Monica; Mur Cecilia; Navarro Paloma; Pons Sebastián; Cassard-Doulcier Anne-Marie; Kahn C Ronald; Benito Manuel
Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes.
The Journal of biological chemistry 2003;278(12):10221-31.
2003: Fisher Simon J; Kahn C Ronald
Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production.
The Journal of clinical investigation 2003;111(4):463-8.
2003: Hallmann Daniel; Trümper Katja; Trusheim Heidi; Ueki Kohjiro; Kahn C Ronald; Cantley Lewis C; Fruman David A; Hörsch Dieter
Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha.
The Journal of biological chemistry 2003;278(7):5099-108.
2003: Blüher Matthias; Kahn Barbara B; Kahn C Ronald
Extended longevity in mice lacking the insulin receptor in adipose tissue.
Science (New York, N.Y.) 2003;299(5606):572-4.
2003: Kahn C Ronald
The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice.
Transactions of the American Clinical and Climatological Association 2003;114():125-48.
2003: Kitamura Tadahiro; Kahn C Ronald; Accili Domenico
Insulin receptor knockout mice.
Annual review of physiology 2003;65():313-32.
2002: Laustsen Palle G; Michael M Dodson; Crute Barbara E; Cohen Shmuel E; Ueki Kohjiro; Kulkarni Rohit N; Keller Susanna R; Lienhard Gustav E; Kahn C Ronald
Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice.
Genes & development 2002;16(24):3213-22.
2002: Shiojima Ichiro; Yefremashvili Mikkael; Luo Zhengyu; Kureishi Yasuko; Takahashi Akihiro; Tao Jingzang; Rosenzweig Anthony; Kahn C Ronald; Abel E Dale; Walsh Kenneth
Akt signaling mediates postnatal heart growth in response to insulin and nutritional status.
The Journal of biological chemistry 2002;277(40):37670-7.
2002: Crackower Michael A; Oudit Gavin Y; Kozieradzki Ivona; Sarao Renu; Sun Hui; Sasaki Takehiko; Hirsch Emilio; Suzuki Akira; Shioi Tetsuo; Irie-Sasaki Junko; Sah Rajan; Cheng Hai-Ying M; Rybin Vitalyi O; Lembo Giuseppe; Fratta Luigi; Oliveira-dos-Santos Antonio J; Benovic Jeffery L; Kahn C Ronald; Izumo Seigo; Steinberg Susan F; Wymann Matthias P; Backx Peter H; Penninger Josef M
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.
Cell 2002;110(6):737-49.
2002: Shirakami A; Toyonaga T; Tsuruzoe K; Shirotani T; Matsumoto K; Yoshizato K; Kawashima J; Hirashima Y; Miyamura N; Kahn C R; Araki E
Heterozygous knockout of the IRS-1 gene in mice enhances obesity-linked insulin resistance: a possible model for the development of type 2 diabetes.
The Journal of endocrinology 2002;174(2):309-19.
2002: Yechoor Vijay K; Patti Mary-Elizabeth; Saccone Robert; Kahn C Ronald
Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10587-92.
2002: Tseng Yu-Hua; Ueki Kohjiro; Kriauciunas Kristina M; Kahn C Ronald
Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin.
The Journal of biological chemistry 2002;277(35):31601-11.
2002: Blüher Matthias; Michael M Dodson; Peroni Odile D; Ueki Kohjiro; Carter Nathan; Kahn Barbara B; Kahn C Ronald
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance.
Developmental cell 2002;3(1):25-38.
2002: Mauvais-Jarvis Franck; Kulkarni Rohit N; Kahn C Ronald
Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance.
Clinical endocrinology 2002;57(1):1-9.
2002: Jost Petra; Fasshauer Mathias; Kahn C Ronald; Benito Manuel; Meyer Marco; Ott Volker; Lowell Bradford B; Klein H Harald; Klein Johannes
Atypical beta-adrenergic effects on insulin signaling and action in beta(3)-adrenoceptor-deficient brown adipocytes.
American journal of physiology. Endocrinology and metabolism 2002;283(1):E146-53.
2002: Hamer I; Foti M; Emkey R; Cordier-Bussat M; Philippe J; De Meyts P; Maeder C; Kahn C R; Carpentier J-L
An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events.
Diabetologia 2002;45(5):657-67.
2002: Kulkarni R N; Holzenberger M; Shih D Q; Ozcan U; Stoffel M; Magnuson M A; Kahn C R
beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.
Nature genetics 2002;31(1):111-5.
2002: Klein Johannes; Fasshauer Mathias; Klein Harald H; Benito Manuel; Kahn C Ronald
Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action.
BioEssays : news and reviews in molecular, cellular and developmental biology 2002;24(4):382-8.
2002: Shoichet Sarah A; Bäumer Anselm T; Stamenkovic Djordje; Sauer Heinrich; Pfeiffer Andreas F H; Kahn C Ronald; Müller-Wieland Dirk; Richter Christoph; Ristow Michael
Frataxin promotes antioxidant defense in a thiol-dependent manner resulting in diminished malignant transformation in vitro.
Human molecular genetics 2002;11(7):815-21.
2002: Belke Darrell D; Betuing Sandrine; Tuttle Martin J; Graveleau Christophe; Young Martin E; Pham Mark; Zhang Dongfang; Cooksey Robert C; McClain Donald A; Litwin Sheldon E; Taegtmeyer Heinrich; Severson David; Kahn C Ronald; Abel E Dale
Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression.
The Journal of clinical investigation 2002;109(5):629-39.
2002: Mur Cecilia; Valverde Angela M; Kahn C Ronald; Benito Manuel
Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes.
Diabetes 2002;51(3):743-54.
2002: Almind Katrine; Delahaye Laurent; Hansen Torben; Van Obberghen Emmanuel; Pedersen Oluf; Kahn C Ronald
Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2124-8.
2002: Roper Michael G; Qian Wei-jun; Zhang Bei B; Kulkarni Rohit N; Kahn C Ronald; Kennedy Robert T
Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells.
Diabetes 2002;51 Suppl 1():S43-9.
2002: Ueki Kohjiro; Fruman David A; Brachmann Saskia M; Tseng Yu-Hua; Cantley Lewis C; Kahn C Ronald
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.
Molecular and cellular biology 2002;22(3):965-77.
2002: Mauvais-Jarvis Franck; Ueki Kohjiro; Fruman David A; Hirshman Michael F; Sakamoto Kei; Goodyear Laurie J; Iannacone Matteo; Accili Domenico; Cantley Lewis C; Kahn C Ronald
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.
The Journal of clinical investigation 2002;109(1):141-9.
2002: Maeshima Yohei; Sudhakar Akulapalli; Lively Julie C; Ueki Kohjiro; Kharbanda Surender; Kahn C Ronald; Sonenberg Nahum; Hynes Richard O; Kalluri Raghu
Tumstatin, an endothelial cell-specific inhibitor of protein synthesis.
Science (New York, N.Y.) 2002;295(5552):140-3.
2002: Ueki Kohjiro; Yballe Claudine M; Brachmann Saskia M; Vicent David; Watt John M; Kahn C Ronald; Cantley Lewis C
Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):419-24.
2001: Saltiel A R; Kahn C R
Insulin signalling and the regulation of glucose and lipid metabolism.
Nature 2001;414(6865):799-806.
2001: Guerra C; Navarro P; Valverde A M; Arribas M; Brüning J; Kozak L P; Kahn C R; Benito M
Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.
The Journal of clinical investigation 2001;108(8):1205-13.
2001: Kim J K; Zisman A; Fillmore J J; Peroni O D; Kotani K; Perret P; Zong H; Dong J; Kahn C R; Kahn B B; Shulman G I
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4.
The Journal of clinical investigation 2001;108(1):153-60.
2001: Flier S N; Kulkarni R N; Kahn C R
Evidence for a circulating islet cell growth factor in insulin-resistant states.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7475-80.
2001: Valverde A M; Mur C; Pons S; Alvarez A M; White M F; Kahn C R; Benito M
Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis.
Molecular and cellular biology 2001;21(7):2269-80.
2001: Tseng Y H; Vicent D; Zhu J; Niu Y; Adeyinka A; Moyers J S; Watson P H; Kahn C R
Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23.
Cancer research 2001;61(5):2071-9.
2001: Reynet C; Kahn C R
Unbalanced expression of the different subunits of elongation factor 1 in diabetic skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3422-7.
2001: Fasshauer M; Klein J; Kriauciunas K M; Ueki K; Benito M; Kahn C R
Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes.
Molecular and cellular biology 2001;21(1):319-29.
2001: Tsuruzoe K; Emkey R; Kriauciunas K M; Ueki K; Kahn C R
Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling.
Molecular and cellular biology 2001;21(1):26-38.
2000: Mauvais-Jarvis F; Virkamaki A; Michael M D; Winnay J N; Zisman A; Kulkarni R N; Kahn C R
A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.
Diabetes 2000;49(12):2126-34.
2000: Kahn C R; Chen L; Cohen S E
Unraveling the mechanism of action of thiazolidinediones.
The Journal of clinical investigation 2000;106(11):1305-7.
2000: Fruman D A; Mauvais-Jarvis F; Pollard D A; Yballe C M; Brazil D; Bronson R T; Kahn C R; Cantley L C
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha.
Nature genetics 2000;26(3):379-82.
2000: Ueki K; Algenstaedt P; Mauvais-Jarvis F; Kahn C R
Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit.
Molecular and cellular biology 2000;20(21):8035-46.
2000: Ristow M; Pfister M F; Yee A J; Schubert M; Michael L; Zhang C Y; Ueki K; Michael M D; Lowell B B; Kahn C R
Frataxin activates mitochondrial energy conversion and oxidative phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12239-43.
2000: Brüning J C; Gautam D; Burks D J; Gillette J; Schubert M; Orban P C; Klein R; Krone W; Müller-Wieland D; Kahn C R
Role of brain insulin receptor in control of body weight and reproduction.
Science (New York, N.Y.) 2000;289(5487):2122-5.
2000: Hebinck J; Hardt C; Schöls L; Vorgerd M; Briedigkeit L; Kahn C R; Ristow M
Heterozygous expansion of the GAA tract of the X25/frataxin gene is associated with insulin resistance in humans.
Diabetes 2000;49(9):1604-7.
2000: Kriauciunas K M; Myers M G; Kahn C R
Cellular compartmentalization in insulin action: altered signaling by a lipid-modified IRS-1.
Molecular and cellular biology 2000;20(18):6849-59.
2000: Zisman A; Peroni O D; Abel E D; Michael M D; Mauvais-Jarvis F; Lowell B B; Wojtaszewski J F; Hirshman M F; Virkamaki A; Goodyear L J; Kahn C R; Kahn B B
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.
Nature medicine 2000;6(8):924-8.
2000: Fasshauer M; Klein J; Ueki K; Kriauciunas K M; Benito M; White M F; Kahn C R
Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes.
The Journal of biological chemistry 2000;275(33):25494-501.
2000: Michael M D; Kulkarni R N; Postic C; Previs S F; Shulman G I; Magnuson M A; Kahn C R
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.
Molecular cell 2000;6(1):87-97.
2000: Aspinwall C A; Qian W J; Roper M G; Kulkarni R N; Kahn C R; Kennedy R T
Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells.
The Journal of biological chemistry 2000;275(29):22331-8.
2000: Kim J K; Michael M D; Previs S F; Peroni O D; Mauvais-Jarvis F; Neschen S; Kahn B B; Kahn C R; Shulman G I
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle.
The Journal of clinical investigation 2000;105(12):1791-7.
2000: Winnay J N; Brüning J C; Burks D J; Kahn C R
Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts.
The Journal of biological chemistry 2000;275(14):10545-50.
2000: Goldfine A B; Patti M E; Zuberi L; Goldstein B J; LeBlanc R; Landaker E J; Jiang Z Y; Willsky G R; Kahn C R
Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies.
Metabolism: clinical and experimental 2000;49(3):400-10.
2000: Bruning J C; Gillette J A; Zhao Y; Bjorbaeck C; Kotzka J; Knebel B; Avci H; Hanstein B; Lingohr P; Moller D E; Krone W; Kahn C R; Muller-Wieland D
Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2462-7.
2000: Vicent D; Maratos-Flier E; Kahn C R
The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis.
Molecular and cellular biology 2000;20(6):2158-66.
2000: Szanto I; Kahn C R
Selective interaction between leptin and insulin signaling pathways in a hepatic cell line.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2355-60.
2000: Kahn C R; Brüning J C; Michael M D; Kulkarni R N
Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus.
Journal of pediatric endocrinology & metabolism : JPEM 2000;13 Suppl 6():1377-84.
1999: Inoue G; Cheatham B; Kahn C R
Development of an in vitro reconstitution assay for glucose transporter 4 translocation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):14919-24.
1999: Zhu J; Tseng Y H; Kantor J D; Rhodes C J; Zetter B R; Moyers J S; Kahn C R
Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):14911-8.
1999: Kulkarni R N; Winnay J N; Daniels M; Brüning J C; Flier S N; Hanahan D; Kahn C R
Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.
The Journal of clinical investigation 1999;104(12):R69-75.
1999: Klein J; Fasshauer M; Ito M; Lowell B B; Benito M; Kahn C R
beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes.
The Journal of biological chemistry 1999;274(49):34795-802.
1999: Hörsch D; Kahn C R
Region-specific mRNA expression of phosphatidylinositol 3-kinase regulatory isoforms in the central nervous system of C57BL/6J mice.
The Journal of comparative neurology 1999;415(1):105-20.
1999: Wojtaszewski J F; Higaki Y; Hirshman M F; Michael M D; Dufresne S D; Kahn C R; Goodyear L J
Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice.
The Journal of clinical investigation 1999;104(9):1257-64.
1999: Valverde A M; Kahn C R; Benito M
Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.
Diabetes 1999;48(11):2122-31.
1999: Patti M E; Virkamäki A; Landaker E J; Kahn C R; Yki-Järvinen H
Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.
Diabetes 1999;48(8):1562-71.
1999: Virkamäki A; Ueki K; Kahn C R
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance.
The Journal of clinical investigation 1999;103(7):931-43.
1999: Kulkarni R N; Brüning J C; Winnay J N; Postic C; Magnuson M A; Kahn C R
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
Cell 1999;96(3):329-39.
1998: Brüning J C; Michael M D; Winnay J N; Hayashi T; Hörsch D; Accili D; Goodyear L J; Kahn C R
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.
Molecular cell 1998;2(5):559-69.
1998: Vicent D; Piper M; Gammeltoft S; Maratos-Flier E; Kahn C R
Alterations in skeletal muscle gene expression of ob/ob mice by mRNA differential display.
Diabetes 1998;47(9):1451-8.
1998: Bilan P J; Moyers J S; Kahn C R
The ras-related protein rad associates with the cytoskeleton in a non-lipid-dependent manner.
Experimental cell research 1998;242(2):391-400.
1998: Moyers J S; Zhu J; Kahn C R
Effects of phosphorylation on function of the Rad GTPase.
The Biochemical journal 1998;333 ( Pt 3)():609-14.
1998: Ristow M; Giannakidou E; Hebinck J; Busch K; Vorgerd M; Kotzka J; Knebel B; Mueller-Berghaus J; Epplen C; Pfeiffer A; Kahn C R; Doria A; Krone W; Mueller-Wieland D
An association between NIDDM and a GAA trinucleotide repeat polymorphism in the X25/frataxin (Friedreich's ataxia) gene.
Diabetes 1998;47(5):851-4.
1998: Inoue G; Cheatham B; Emkey R; Kahn C R
Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2.
The Journal of biological chemistry 1998;273(19):11548-55.
1998: Patti M E; Brambilla E; Luzi L; Landaker E J; Kahn C R
Bidirectional modulation of insulin action by amino acids.
The Journal of clinical investigation 1998;101(7):1519-29.
1998: Patti M E; Kahn C R
The insulin receptor--a critical link in glucose homeostasis and insulin action.
Journal of basic and clinical physiology and pharmacology 1998;9(2-4):89-109.
1997: Kerouz N J; Hörsch D; Pons S; Kahn C R
Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.
The Journal of clinical investigation 1997;100(12):3164-72.
1997: Emkey R; Kahn C R
Cross-talk between phorbol ester-mediated signaling and tyrosine kinase proto-oncogenes. II. Comparison of phorbol ester and sphingomyelinase-induced phosphorylation of ErbB2 and ErbB3.
The Journal of biological chemistry 1997;272(49):31182-9.
1997: Emkey R; Kahn C R
Cross-talk between phorbol ester-mediated signaling and tyrosine kinase proto-oncogenes. I. Activation of protein kinase C stimulates tyrosine phosphorylation and activation of ErbB2 and ErbB3.
The Journal of biological chemistry 1997;272(49):31172-81.
1997: Zhu J; Kahn C R
Analysis of a peptide hormone-receptor interaction in the yeast two-hybrid system.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13063-8.
1997: Algenstaedt P; Antonetti D A; Yaffe M B; Kahn C R
Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart.
The Journal of biological chemistry 1997;272(38):23696-702.
1997: Smith-Hall J; Pons S; Patti M E; Burks D J; Yenush L; Sun X J; Kahn C R; White M F
The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells.
Biochemistry 1997;36(27):8304-10.
1997: Kim S J; Kahn C R
Insulin stimulates p70 S6 kinase in the nucleus of cells.
Biochemical and biophysical research communications 1997;234(3):681-5.
1997: Moyers J S; Bilan P J; Zhu J; Kahn C R
Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II.
The Journal of biological chemistry 1997;272(18):11832-9.
1997: Brüning J C; Winnay J; Cheatham B; Kahn C R
Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells.
Molecular and cellular biology 1997;17(3):1513-21.
1997: Brüning J C; Winnay J; Bonner-Weir S; Taylor S I; Accili D; Kahn C R
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.
Cell 1997;88(4):561-72.
1996: Cheatham B; Volchuk A; Kahn C R; Wang L; Rhodes C J; Klip A
Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15169-73.
1996: Patti M E; Kahn C R
Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus.
Trends in endocrinology and metabolism: TEM 1996;7(9):311-9.
1996: Inoue G; Cheatham B; Kahn C R
Different pathways of postreceptor desensitization following chronic insulin treatment and in cells overexpressing constitutively active insulin receptors.
The Journal of biological chemistry 1996;271(45):28206-11.
1996: Folli F; Ghidella S; Bonfanti L; Kahn C R; Merighi A
The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system.
Molecular neurobiology 1996;13(2):155-83.
1996: Velloso L A; Folli F; Sun X J; White M F; Saad M J; Kahn C R
Cross-talk between the insulin and angiotensin signaling systems.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12490-5.
1996: Folli F; Saad M J; Kahn C R
Insulin receptor/IRS-1/PI 3-kinase signaling system in corticosteroid-induced insulin resistance.
Acta diabetologica 1996;33(3):185-92.
1996: Moyers J S; Bilan P J; Reynet C; Kahn C R
Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells.
The Journal of biological chemistry 1996;271(38):23111-6.
1996: Almind K; Inoue G; Pedersen O; Kahn C R
A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies.
The Journal of clinical investigation 1996;97(11):2569-75.
1996: Antonetti D A; Algenstaedt P; Kahn C R
Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain.
Molecular and cellular biology 1996;16(5):2195-203.
1996: Reynet C; Kahn C R; Loeken M R
Expression of the gene encoding glycogen phosphorylase is elevated in diabetic rat skeletal muscle and is regulated by insulin and cyclic AMP.
Diabetologia 1996;39(2):183-9.
1996: Zhu J; Bilan P J; Moyers J S; Antonetti D A; Kahn C R
Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin.
The Journal of biological chemistry 1996;271(2):768-73.
1995: Goldfine A B; Simonson D C; Folli F; Patti M E; Kahn C R
In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus.
Molecular and cellular biochemistry 1995;153(1-2):217-31.
1995: Goldfine A B; Simonson D C; Folli F; Patti M E; Kahn C R
Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies.
The Journal of clinical endocrinology and metabolism 1995;80(11):3311-20.
1995: Araki E; Haag B L; Matsuda K; Shichiri M; Kahn C R
Characterization and regulation of the mouse insulin receptor substrate gene promoter.
Molecular endocrinology (Baltimore, Md.) 1995;9(10):1367-79.
1995: Patti M E; Sun X J; Bruening J C; Araki E; Lipes M A; White M F; Kahn C R
4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice.
The Journal of biological chemistry 1995;270(42):24670-3.
1995: Myers M G; Cheatham B; Fisher T L; Jachna B R; Kahn C R; Backer J M; White M F
Common and distinct elements in insulin and PDGF signaling.
Annals of the New York Academy of Sciences 1995;766():369-87.
1995: Magré J; Goldfine A B; Warram J H; Krolewski A S; Kahn C R
Analysis of the insulin receptor gene in noninsulin-dependent diabetes mellitus by denaturing gradient gel blots: a clinical research center study.
The Journal of clinical endocrinology and metabolism 1995;80(6):1882-7.
1995: Saad M J; Folli F; Kahn C R
Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells.
Endocrinology 1995;136(4):1579-88.
1995: Cheatham B; Kahn C R
Insulin action and the insulin signaling network.
Endocrine reviews 1995;16(2):117-42.
1995: Zhu J; Reynet C; Caldwell J S; Kahn C R
Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity.
The Journal of biological chemistry 1995;270(9):4805-12.
1995: Antonetti D A; Reynet C; Kahn C R
Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus.
The Journal of clinical investigation 1995;95(3):1383-8.
1995: Doria A; Caldwell J S; Ji L; Reynet C; Rich S S; Weremowicz S; Morton C C; Warram J H; Kahn C R; Krolewski A S
Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q.
Diabetes 1995;44(2):243-7.
1995: Yamada K; Carpentier J L; Cheatham B; Goncalves E; Shoelson S E; Kahn C R
Role of the transmembrane domain and flanking amino acids in internalization and down-regulation of the insulin receptor.
The Journal of biological chemistry 1995;270(7):3115-22.
1995: Yamada K; Goncalves E; Carpentier J L; Kahn C R; Shoelson S E
Transmembrane domain inversion blocks ER release and insulin receptor signaling.
Biochemistry 1995;34(3):946-54.
1994: Ferber S; Meyerovitch J; Kriauciunas K M; Kahn C R
Vanadate normalizes hyperglycemia and phosphoenolpyruvate carboxykinase mRNA levels in ob/ob mice.
Metabolism: clinical and experimental 1994;43(11):1346-54.
1994: Folli F; Bonfanti L; Renard E; Kahn C R; Merighi A
Insulin receptor substrate-1 (IRS-1) distribution in the rat central nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(11 Pt 1):6412-22.
1994: Chuang L M; Hausdorff S F; Myers M G; White M F; Birnbaum M J; Kahn C R
Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes.
The Journal of biological chemistry 1994;269(44):27645-9.
1994: Araki E; Lipes M A; Patti M E; Brüning J C; Haag B; Johnson R S; Kahn C R
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.
Nature 1994;372(6502):186-90.
1994: Kahn C R
Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes.
Diabetes 1994;43(8):1066-84.
1994: Alarcón C; Cheatham B; Lincoln B; Kahn C R; Siddle K; Rhodes C J
A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor.
The Biochemical journal 1994;301 ( Pt 1)():257-65.
1994: Cheatham B; Vlahos C J; Cheatham L; Wang L; Blenis J; Kahn C R
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.
Molecular and cellular biology 1994;14(7):4902-11.
1994: Wilden P A; Kahn C R
The level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase, microtubule-associated protein, and S6 kinases.
Molecular endocrinology (Baltimore, Md.) 1994;8(5):558-67.
1994: Saad M J; Folli F; Araki E; Hashimoto N; Csermely P; Kahn C R
Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone.
Molecular endocrinology (Baltimore, Md.) 1994;8(5):545-57.
1994: Edge A S; Karasik A; Yamada K; Kahn C R
Effect of dexamethasone on the carbohydrate chains of the insulin receptor.
Biochemical and biophysical research communications 1994;200(2):852-9.
1994: Araki E; Haag B L; Kahn C R
Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1.
Biochimica et biophysica acta 1994;1221(3):353-6.
1994: Kim S J; Kahn C R
Insulin stimulates phosphorylation of c-Jun, c-Fos, and Fos-related proteins in cultured adipocytes.
The Journal of biological chemistry 1994;269(16):11887-92.
1994: White M F; Kahn C R
The insulin signaling system.
The Journal of biological chemistry 1994;269(1):1-4.
1993: Chuang L M; Myers M G; Backer J M; Shoelson S E; White M F; Birnbaum M J; Kahn C R
Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase.
Molecular and cellular biology 1993;13(11):6653-60.
1993: Reynet C; Kahn C R
Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans.
Science (New York, N.Y.) 1993;262(5138):1441-4.
1993: Kim S J; Kahn C R
Insulin induces rapid accumulation of insulin receptors and increases tyrosine kinase activity in the nucleus of cultured adipocytes.
Journal of cellular physiology 1993;157(2):217-28.
1993: Saad M J; Folli F; Kahn J A; Kahn C R
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.
The Journal of clinical investigation 1993;92(4):2065-72.
1993: Folli F; Saad M J; Backer J M; Kahn C R
Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.
The Journal of clinical investigation 1993;92(4):1787-94.
1993: Cheatham B; Shoelson S E; Yamada K; Goncalves E; Kahn C R
Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(15):7336-40.
1993: Araki E; Sun X J; Haag B L; Chuang L M; Zhang Y; Yang-Feng T L; White M F; Kahn C R
Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization.
Diabetes 1993;42(7):1041-54.
1993: Goncalves E; Yamada K; Thatte H S; Backer J M; Golan D E; Kahn C R; Shoelson S E
Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(12):5762-6.
1993: Chuang L M; Myers M G; Seidner G A; Birnbaum M J; White M F; Kahn C R
Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5172-5.
1993: Feener E P; Backer J M; King G L; Wilden P A; Sun X J; Kahn C R; White M F
Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor.
The Journal of biological chemistry 1993;268(15):11256-64.
1993: Csermely P; Schnaider T; Cheatham B; Olson M O; Kahn C R
Insulin induces the phosphorylation of nucleolin. A possible mechanism of insulin-induced RNA efflux from nuclei.
The Journal of biological chemistry 1993;268(13):9747-52.
1993: Kahn C R; Goldfine A B
Molecular determinants of insulin action.
Journal of diabetes and its complications 1993;7(2):92-105.
1993: Kriauciunas K M; Goldstein B J; Lipes M A; Kahn C R
Modulation of expression of insulin and IGF-I receptor by Epstein-Barr virus and its gene products LMP and EBNA-2 in lymphocyte cell lines.
Journal of cellular physiology 1993;154(3):486-95.
1993: Kahn C R; White M F; Shoelson S E; Backer J M; Araki E; Cheatham B; Csermely P; Folli F; Goldstein B J; Huertas P
The insulin receptor and its substrate: molecular determinants of early events in insulin action.
Recent progress in hormone research 1993;48():291-339.
1992: Sun X J; Miralpeix M; Myers M G; Glasheen E M; Backer J M; Kahn C R; White M F
Expression and function of IRS-1 in insulin signal transmission.
The Journal of biological chemistry 1992;267(31):22662-72.
1992: Folli F; Saad M J; Backer J M; Kahn C R
Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.
The Journal of biological chemistry 1992;267(31):22171-7.
1992: Saad M J; Araki E; Miralpeix M; Rothenberg P L; White M F; Kahn C R
Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.
The Journal of clinical investigation 1992;90(5):1839-49.
1992: Kahn C R; Saad M J
Alterations in insulin receptor and substrate phosphorylation in hypertensive rats.
Journal of the American Society of Nephrology : JASN 1992;3(4 Suppl):S69-77.
1992: Meyerovitch J; Backer J M; Csermely P; Shoelson S E; Kahn C R
Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells.
Biochemistry 1992;31(42):10338-44.
1992: Csermely P; Kahn C R
Insulin induces the phosphorylation of DNA-binding nuclear proteins including lamins in 3T3-F442A.
Biochemistry 1992;31(41):9940-6.
1992: Wilden P A; Kahn C R; Siddle K; White M F
Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function.
The Journal of biological chemistry 1992;267(23):16660-8.
1992: Wilden P A; Siddle K; Haring E; Backer J M; White M F; Kahn C R
The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies.
The Journal of biological chemistry 1992;267(19):13719-27.
1992: Yamada K; Goncalves E; Kahn C R; Shoelson S E
Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro.
The Journal of biological chemistry 1992;267(18):12452-61.
1992: Cheatham B; Kahn C R
Cysteine 647 in the insulin receptor is required for normal covalent interaction between alpha- and beta-subunits and signal transduction.
The Journal of biological chemistry 1992;267(10):7108-15.
1992: Goldstein B J; Zhang W R; Hashimoto N; Kahn C R
Approaches to the molecular cloning of protein-tyrosine phosphatases in insulin-sensitive tissues.
Molecular and cellular biochemistry 1992;109(2):107-13.
1992: Zoppini G; Kahn C R
Effect of phospholipase treatment on insulin receptor signal transduction.
Diabetologia 1992;35(2):109-15.
1992: Hauguel-DeMouzon S; Csermely P; Zoppini G; Kahn C R
Quantitative dissociation between EGF effects on c-myc and c-fos gene expression, DNA synthesis, and epidermal growth factor receptor tyrosine kinase activity.
Journal of cellular physiology 1992;150(1):180-7.
1992: Backer J M; Schroeder G G; Kahn C R; Myers M G; Wilden P A; Cahill D A; White M F
Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.
The Journal of biological chemistry 1992;267(2):1367-74.
1991: Shoelson S E; Boni-Schnetzler M; Pilch P F; Kahn C R
Autophosphorylation within insulin receptor beta-subunits can occur as an intramolecular process.
Biochemistry 1991;30(31):7740-6.
1991: Sun X J; Rothenberg P; Kahn C R; Backer J M; Araki E; Wilden P A; Cahill D A; Goldstein B J; White M F
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein.
Nature 1991;352(6330):73-7.
1991: Rothenberg P L; Lane W S; Karasik A; Backer J; White M; Kahn C R
Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase.
The Journal of biological chemistry 1991;266(13):8302-11.
1991: Meyerovitch J; Rothenberg P; Shechter Y; Bonner-Weir S; Kahn C R
Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1991;87(4):1286-94.
1991: Csermely P; Kahn C R
The 90-kDa heat shock protein (hsp-90) possesses an ATP binding site and autophosphorylating activity.
The Journal of biological chemistry 1991;266(8):4943-50.
1991: Ferber S; Gross D J; Villa-Komaroff L; Danehy F; Vollenweider F; Meyer K; Loeken M R; Kahn C R; Halban P A
Heterogeneity of expression and secretion of native and mutant [AspB10]insulin in AtT20 cells.
Molecular endocrinology (Baltimore, Md.) 1991;5(3):319-26.
1991: Okamoto M; Karasik A; White M F; Kahn C R
Coordinate phosphorylation of insulin-receptor kinase and its 175,000-Mr endogenous substrate in rat hepatocytes.
Diabetes 1991;40(1):66-72.
1991: Hauguel-de Mouzon S; Kahn C R
Insulin-like growth factor-mediated phosphorylation and protooncogene induction in Madin-Darby canine kidney cells.
Molecular endocrinology (Baltimore, Md.) 1991;5(1):51-60.
1990: Okamoto M; Karasik A; White M F; Kahn C R
Epidermal growth factor stimulated phosphorylation of a 120-kilodalton endogenous substrate protein in rat hepatocytes.
Biochemistry 1990;29(40):9489-94.
1990: Edge A S; Kahn C R; Spiro R G
Insulin receptor carbohydrate units contain poly-N-acetyllactosamine chains.
Endocrinology 1990;127(4):1887-95.
1990: Backer J M; Kahn C R; Cahill D A; Ullrich A; White M F
Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.
The Journal of biological chemistry 1990;265(27):16450-4.
1990: Backer J M; Kahn C R; White M F
The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells.
The Journal of biological chemistry 1990;265(25):14828-35.
1990: Karasik A; Rothenberg P L; Yamada K; White M F; Kahn C R
Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats.
The Journal of biological chemistry 1990;265(18):10226-31.
1990: Wilden P A; Backer J M; Kahn C R; Cahill D A; Schroeder G J; White M F
The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3358-62.
1990: Meyerovitch J; Kahn C R; Shechter Y
A family of polypeptide substrates and inhibitors of insulin receptor kinase.
Biochemistry 1990;29(15):3654-60.
1990: Kruszynska Y T; Halban P A; Kahn C R; White M F
Activation of liver and muscle insulin receptor tyrosine kinase activity during in vivo insulin administration in rats.
Diabetologia 1990;33(2):77-83.
1990: Karasik A; Reddy S S; Pepinsky R B; Brock T; Kahn C R
Augmented desensitization to epidermal growth factor (EGF) immediate actions: a novel mechanism for altered EGF growth response in mutant A431 cells.
Journal of cellular physiology 1990;142(2):231-5.
1989: Reddy S S; Kahn C R
Epidermal growth factor receptor defects in leprechaunism. A multiple growth factor-resistant syndrome.
The Journal of clinical investigation 1989;84(5):1569-76.
1989: Hurrell D G; Pedersen O; Kahn C R
Alterations in the hepatic insulin receptor kinase in genetic and acquired obesity in rats.
Endocrinology 1989;125(5):2454-62.
1989: Kahn C R
Perverted priorities. The physician/scientist as spokesman and salesman for biomedical research. Presidential address to the American Society for Clinical Investigation, Washington, DC, 29 April 1989.
The Journal of clinical investigation 1989;84(3):723-7.
1989: Meyerovitch J; Backer J M; Kahn C R
Hepatic phosphotyrosine phosphatase activity and its alterations in diabetic rats.
The Journal of clinical investigation 1989;84(3):976-83.
1989: Reddy S S; Muller-Wieland D; Kriauciunas K; Kahn C R
Molecular defects in the insulin receptor in patients with leprechaunism and in their parents.
The Journal of laboratory and clinical medicine 1989;114(2):165-70.
1989: Goldstein B J; Kahn C R
Insulin receptor messenger ribonucleic acid sequence alterations detected by ribonuclease cleavage in patients with syndromes of insulin resistance.
The Journal of clinical endocrinology and metabolism 1989;69(1):15-24.
1989: Perlman R; Bottaro D P; White M F; Kahn C R
Conformational changes in the alpha- and beta-subunits of the insulin receptor identified by anti-peptide antibodies.
The Journal of biological chemistry 1989;264(15):8946-50.
1989: Kahn C R; Lauris V; Koch S; Crettaz M; Granner D K
Acute and chronic regulation of phosphoenolpyruvate carboxykinase mRNA by insulin and glucose.
Molecular endocrinology (Baltimore, Md.) 1989;3(5):840-5.
1989: Shoelson S E; White M F; Kahn C R
Nonphosphorylatable substrate analogs selectively block autophosphorylation and activation of the insulin receptor, epidermal growth factor receptor, and pp60v-src kinases.
The Journal of biological chemistry 1989;264(14):7831-6.
1989: Backer J M; Kahn C R; White M F
Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3209-13.
1989: White M F; Kahn C R
Cascade of autophosphorylation in the beta-subunit of the insulin receptor.
Journal of cellular biochemistry 1989;39(4):429-41.
1989: Goldstein B J; Kahn C R
Analysis of mRNA heterogeneity by ribonuclease H mapping: application to the insulin receptor.
Biochemical and biophysical research communications 1989;159(2):664-9.
1989: Kwok C F; Goldstein B J; Muller-Wieland D; Lee T S; Kahn C R; King G L
Identification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats.
The Journal of clinical investigation 1989;83(1):127-36.
1989: Cox N J; Spielman R S; Kahn C R; Muller-Wieland D; Kriauciunas K M; Taub R
Four RFLPs of the human insulin receptor gene: PstI, KpnI, RsaI (2 RFLPs).
Nucleic acids research 1989;17(2):820.
1989: Muller-Wieland D; Taub R; Tewari D S; Kriauciunas K M; Sethu S; Reddy K; Kahn C R
Insulin-receptor gene and its expression in patients with insulin resistance.
Diabetes 1989;38(1):31-8.
1989: Backer J M; Kahn C R; White M F
Tyrosine phosphorylation of the insulin receptor during insulin-stimulated internalization in rat hepatoma cells.
The Journal of biological chemistry 1989;264(3):1694-701.
1988: Karasik A; Pepinsky R B; Kahn C R
Insulin and epidermal growth factor stimulate phosphorylation of a 170-kDa protein in intact hepatocytes immunologically related to lipocortin 1.
The Journal of biological chemistry 1988;263(34):18558-62.
1988: Kriauciunas K M; Kahn C R; Muller-Wieland D; Reddy S S; Taub R
Altered expression and function of the insulin receptor in a family with lipoatrophic diabetes.
The Journal of clinical endocrinology and metabolism 1988;67(6):1284-93.
1988: Karasik A; Kahn C R
Dexamethasone-induced changes in phosphorylation of the insulin and epidermal growth factor receptors and their substrates in intact rat hepatocytes.
Endocrinology 1988;123(5):2214-22.
1988: Warram J H; Krolewski A S; Kahn C R
Determinants of IDDM and perinatal mortality in children of diabetic mothers.
Diabetes 1988;37(10):1328-34.
1988: Rothenberg P L; Kahn C R
Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins.
The Journal of biological chemistry 1988;263(30):15546-52.
1988: Reddy S S; Lauris V; Kahn C R
Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization.
The Journal of clinical investigation 1988;82(4):1359-65.
1988: Kahn C R; White M F
The insulin receptor and the molecular mechanism of insulin action.
The Journal of clinical investigation 1988;82(4):1151-6.
1988: Reddy S S; Kahn C R
Insulin resistance: a look at the role of insulin receptor kinase.
Diabetic medicine : a journal of the British Diabetic Association 1988;5(7):621-9.
1988: Goldstein B J; Kahn C R
Initial processing of the insulin receptor precursor in vivo and in vitro.
The Journal of biological chemistry 1988;263(26):12809-12.
1988: Cox N J; Spielman R S; Kahn C R; Müller-Wieland D; Kriauciunas K M; Taub R
Four RFLPs of the human insulin receptor gene: PstI, KpnI, RsaI (2 RFLPs).
Nucleic acids research 1988;16(16):8204.
1988: White M F; Livingston J N; Backer J M; Lauris V; Dull T J; Ullrich A; Kahn C R
Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity.
Cell 1988;54(5):641-9.
1988: Karasik A; Pepinsky R B; Shoelson S E; Kahn C R
Lipocortins 1 and 2 as substrates for the insulin receptor kinase in rat liver.
The Journal of biological chemistry 1988;263(24):11862-7.
1988: Ludwig S; Muller-Wieland D; Goldstein B J; Kahn C R
The insulin receptor gene and its expression in insulin-resistant mice.
Endocrinology 1988;123(1):594-600.
1988: Takayama S; Kahn C R; Kubo K; Foley J E
Alterations in insulin receptor autophosphorylation in insulin resistance: correlation with altered sensitivity to glucose transport and antilipolysis to insulin.
The Journal of clinical endocrinology and metabolism 1988;66(5):992-9.
1988: Okamoto M; Kahn C R; Maron R; White M F
Decreased autophosphorylation of EGF receptor in insulin-deficient diabetic rats.
The American journal of physiology 1988;254(4 Pt 1):E429-34.
1988: Shoelson S E; White M F; Kahn C R
Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control.
The Journal of biological chemistry 1988;263(10):4852-60.
1988: Takayama S; White M F; Kahn C R
Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.
The Journal of biological chemistry 1988;263(7):3440-7.
1988: White M F; Shoelson S E; Keutmann H; Kahn C R
A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.
The Journal of biological chemistry 1988;263(6):2969-80.
1988: Crettaz M; Muller-Wieland D; Kahn C R
Transcriptional and posttranscriptional regulation of tyrosine aminotransferase by insulin in rat hepatoma cells.
Biochemistry 1988;27(1):495-500.
1987: Goldstein B J; Muller-Wieland D; Kahn C R
Variation in insulin receptor messenger ribonucleic acid expression in human and rodent tissues.
Molecular endocrinology (Baltimore, Md.) 1987;1(11):759-66.
1987: Karasik A; Kahn C R
Antibodies to the insulin receptor as tools in the study of receptor structure and function.
Annals of the New York Academy of Sciences 1987;505():301-12.
1986: Lauris V; Crettaz M; Kahn C R
Coordinate roles of insulin and glucose on the growth of hepatoma cells in culture.
Endocrinology 1986;118(6):2519-24.
1985: Herzberg V L; Grigorescu F; Edge A S; Spiro R G; Kahn C R
Characterization of insulin receptor carbohydrate by comparison of chemical and enzymatic deglycosylation.
Biochemical and biophysical research communications 1985;129(3):789-96.
1983: Fehlmann M; Crettaz M; Kahn C R
Glucagon resistance of hepatoma cells. Evidence for receptor and post-receptor defects.
The Biochemical journal 1983;214(3):845-50.
1983: Kahn C R; Lauris V; Fehlmann M; Crettaz M
Expression of insulin receptors and insulin action in cell hybrids and cybrids.
The Biochemical journal 1983;214(2):309-16.
1983: Crettaz M; Kahn C R; Fehlmann M
Glucagon regulation of amino acid transport in hepatocytes: effect of cell enucleation.
Journal of cellular physiology 1983;115(2):186-90.

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Ronald Kahn

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