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Steven Kahn

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Anatomy

Disorders

Procedures

Glucose Tolerance Test

Activities & Behaviors

Fasting

Living Beings

Geographic Areas

Japan

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Co-Publications
Name
34
Fujimoto, Wilfred
29
Boyko, Edward
29
Hull, Rebecca
28
Utzschneider, Kristina
27
Porte, Daniel
23
Prigeon, Ronald
20
Leonetti, Donna
19
Schwartz, Michael
18
Carr, Darcy
16
Schwartz, Robert
16
Verchere, Bruce
16
Zraika, Sakeneh
16
Tong, Jenny
14
McNeely, Marguerite
13
Knopp, Robert

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Publications

TOP 3
Gerchman Fernando; Tong Jenny; Utzschneider Kristina M; Zraika Sakeneh; Udayasankar Jayalakshmi; McNeely Marguerite J; Carr Darcy B; Leonetti Donna L; Young Bessie A; de Boer Ian H; Boyko Edward J; Fujimoto Wilfred Y; Kahn Steven E
Body mass index is associated with increased creatinine clearance by a mechanism independent of body fat distribution.
Hull R L; Zraika S; Udayasankar J; Aston-Mourney K; Subramanian S L; Kahn S E
Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress.
Kahn S E; Zraika S; Utzschneider K M; Hull R L
The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality.

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All Publications

2009: Gerchman Fernando; Tong Jenny; Utzschneider Kristina M; Zraika Sakeneh; Udayasankar Jayalakshmi; McNeely Marguerite J; Carr Darcy B; Leonetti Donna L; Young Bessie A; de Boer Ian H; Boyko Edward J; Fujimoto Wilfred Y; Kahn Steven E
Body mass index is associated with increased creatinine clearance by a mechanism independent of body fat distribution.
The Journal of clinical endocrinology and metabolism 2009;94(10):3781-8.
2009: Hull R L; Zraika S; Udayasankar J; Aston-Mourney K; Subramanian S L; Kahn S E
Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress.
Diabetologia 2009;52(6):1102-11.
2009: Kahn S E; Zraika S; Utzschneider K M; Hull R L
The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality.
Diabetologia 2009;52(6):1003-12.
2009: Kahn Steven E
Glucose control in type 2 diabetes: still worthwhile and worth pursuing.
JAMA : the journal of the American Medical Association 2009;301(15):1590-2.
2009: Zraika S; Hull R L; Udayasankar J; Aston-Mourney K; Subramanian S L; Kisilevsky R; Szarek W A; Kahn S E
Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis.
Diabetologia 2009;52(4):626-35.
2009: Utzschneider Kristina M; Prigeon Ronald L; Faulenbach Mirjam V; Tong Jenny; Carr Darcy B; Boyko Edward J; Leonetti Donna L; McNeely Marguerite J; Fujimoto Wilfred Y; Kahn Steven E
Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels.
Diabetes care 2009;32(2):335-41.
2009: Udayasankar J; Kodama K; Hull R L; Zraika S; Aston-Mourney K; Subramanian S L; Tong J; Faulenbach M V; Vidal J; Kahn S E
Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets.
Diabetologia 2009;52(1):145-53.
2008: Hayashi Tomoshige; Boyko Edward J; McNeely Marguerite J; Leonetti Donna L; Kahn Steven E; Fujimoto Wilfred Y
Visceral adiposity, not abdominal subcutaneous fat area, is associated with an increase in future insulin resistance in Japanese Americans.
Diabetes 2008;57(5):1269-75.
2008: Kahn Steven E; Zinman Bernard; Lachin John M; Haffner Steven M; Herman William H; Holman Rury R; Kravitz Barbara G; Yu Dahong; Heise Mark A; Aftring R Paul; Viberti Giancarlo;
Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from A Diabetes Outcome Progression Trial (ADOPT).
Diabetes care 2008;31(5):845-51.
2008: Kratz Mario; Purnell Jonathan Q; Breen Patricia A; Thomas Katherine K; Utzschneider Kristina M; Carr Darcy B; Kahn Steven E; Hughes James P; Rutledge Elizabeth A; Van Yserloo Brian; Yukawa Michi; Weigle David S
Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy.
The Journal of clinical endocrinology and metabolism 2008;93(3):959-66.
2008: Utzschneider Kristina M; Tong Jenny; Montgomery Brenda; Udayasankar Jayalakshmi; Gerchman Fernando; Marcovina Santica M; Watson Catherine E; Ligueros-Saylan Monica A; Foley James E; Holst Jens J; Deacon Carolyn F; Kahn Steven E
The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose.
Diabetes care 2008;31(1):108-13.
2007: Utzschneider K M; Prigeon R L; Tong J; Gerchman F; Carr D B; Zraika S; Udayasankar J; Montgomery B; Mari A; Kahn S E
Within-subject variability of measures of beta cell function derived from a 2 h OGTT: implications for research studies.
Diabetologia 2007;50(12):2516-25.
2007: Hull Rebecca L; Zraika Sakeneh; Udayasankar Jayalakshmi; Kisilevsky Robert; Szarek Walter A; Wight Thomas N; Kahn Steven E
Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro.
American journal of physiology. Cell physiology 2007;293(5):C1586-93.
2007: Wallace Tara M; Utzschneider Kristina M; Tong Jenny; Carr Darcy B; Zraika Sakeneh; Bankson Daniel D; Knopp Robert H; Kahn Steven E
Relationship of liver enzymes to insulin sensitivity and intra-abdominal fat.
Diabetes care 2007;30(10):2673-8.
2007: Gerchman Fernando; Tong Jenny; Utzschneider Kristina M; Hull Rebecca L; Zraika Sakeneh; Udayasankar Jayalakshmi; McNeely Marguerite J; Andress Dennis L; Leonetti Donna L; Boyko Edward J; Fujimoto Wilfred Y; Kahn Steven E
Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans.
Diabetes research and clinical practice 2007;77(2):320-6.
2007: Tong J; Boyko E J; Utzschneider K M; McNeely M J; Hayashi T; Carr D B; Wallace T M; Zraika S; Gerchman F; Leonetti D L; Fujimoto W Y; Kahn S E
Intra-abdominal fat accumulation predicts the development of the metabolic syndrome in non-diabetic Japanese-Americans.
Diabetologia 2007;50(6):1156-60.
2007: Cnop Miriam; Vidal Josep; Hull Rebecca L; Utzschneider Kristina M; Carr Darcy B; Schraw Todd; Scherer Philipp E; Boyko Edward J; Fujimoto Wilfred Y; Kahn Steven E
Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes.
Diabetes care 2007;30(3):677-82.
2007: Zraika Sakeneh; Hull Rebecca L; Udayasankar Jayalakshmi; Utzschneider Kristina M; Tong Jenny; Gerchman Fernando; Kahn Steven E
Glucose- and time-dependence of islet amyloid formation in vitro.
Biochemical and biophysical research communications 2007;354(1):234-9.
2007: Zraika Sakeneh; Hull Rebecca L; Udayasankar Jayalakshmi; Clark Anne; Utzschneider Kristina M; Tong Jenny; Gerchman Fernando; Kahn Steven E
Identification of the amyloid-degrading enzyme neprilysin in mouse islets and potential role in islet amyloidogenesis.
Diabetes 2007;56(2):304-10.
2007: Tong J; Utzschneider K M; Carr D B; Zraika S; Udayasankar J; Gerchman F; Knopp R H; Kahn S E
Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects.
Diabetologia 2007;50(2):439-42.
2007: Hayashi Tomoshige; Boyko Edward J; McNeely Marguerite J; Leonetti Donna L; Kahn Steven E; Fujimoto Wilfred Y
Minimum waist and visceral fat values for identifying Japanese Americans at risk for the metabolic syndrome.
Diabetes care 2007;30(1):120-7.
2006: Kahn Steven E; Hull Rebecca L; Utzschneider Kristina M
Mechanisms linking obesity to insulin resistance and type 2 diabetes.
Nature 2006;444(7121):840-6.
2006: Kahn Steven E; Haffner Steven M; Heise Mark A; Herman William H; Holman Rury R; Jones Nigel P; Kravitz Barbara G; Lachin John M; O'Neill M Colleen; Zinman Bernard; Viberti Giancarlo;
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.
The New England journal of medicine 2006;355(23):2427-43.
2006: van Genugten Renate E; Utzschneider Kristina M; Tong Jenny; Gerchman Fernando; Zraika Sakeneh; Udayasankar Jayalakshmi; Boyko Edward J; Fujimoto Wilfred Y; Kahn Steven E;
Effects of sex and hormone replacement therapy use on the prevalence of isolated impaired fasting glucose and isolated impaired glucose tolerance in subjects with a family history of type 2 diabetes.
Diabetes 2006;55(12):3529-35.
2006: Viberti G; Lachin J; Holman R; Zinman B; Haffner S; Kravitz B; Heise M A; Jones N P; O'Neill M C; Freed M I; Kahn S E; Herman W H;
A Diabetes Outcome Progression Trial (ADOPT): baseline characteristics of Type 2 diabetic patients in North America and Europe.
Diabetic medicine : a journal of the British Diabetic Association 2006;23(12):1289-94.
2006: Utzschneider Kristina M; Kahn Steven E
Review: The role of insulin resistance in nonalcoholic fatty liver disease.
The Journal of clinical endocrinology and metabolism 2006;91(12):4753-61.
2006: Krudys Kevin M; Kahn Steven E; Vicini Paolo
Population approaches to estimate minimal model indexes of insulin sensitivity and glucose effectiveness using full and reduced sampling schedules.
American journal of physiology. Endocrinology and metabolism 2006;291(4):E716-23.
2006: Carr Darcy B; Utzschneider Kristina M; Hull Rebecca L; Tong Jenny; Wallace Tara M; Kodama Keiichi; Shofer Jane B; Heckbert Susan R; Boyko Edward J; Fujimoto Wilfred Y; Kahn Steven E
Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes.
Diabetes care 2006;29(9):2078-83.
2006: Kahn Steven E; Zinman Bernard; Haffner Steven M; O'Neill M Colleen; Kravitz Barbara G; Yu Dahong; Freed Martin I; Herman William H; Holman Rury R; Jones Nigel P; Lachin John M; Viberti Giancarlo C;
Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetes.
Diabetes 2006;55(8):2357-64.
2006: Utzschneider Kristina M; Prigeon Ronald L; Carr Darcy B; Hull Rebecca L; Tong Jenny; Shofer Jane B; Retzlaff Barbara M; Knopp Robert H; Kahn Steven E
Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between insulin sensitivity and insulin responses.
Diabetes care 2006;29(2):356-62.
2005: Utzschneider K M; Carr D B; Tong J; Wallace T M; Hull R L; Zraika S; Xiao Q; Mistry J S; Retzlaff B M; Knopp R H; Kahn S E
Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans.
Diabetologia 2005;48(11):2330-3.
2005: Hull Rebecca L; Watts Melissah R; Kodama Keiichi; Shen Zhen-ping; Utzschneider Kristina M; Carr Darcy B; Vidal Josep; Kahn Steven E
Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice.
American journal of physiology. Endocrinology and metabolism 2005;289(4):E703-9.
2005: Hull Rebecca L; Shen Zhen-Ping; Watts Melissah R; Kodama Keiichi; Carr Darcy B; Utzschneider Kristina M; Zraika Sakeneh; Wang Feng; Kahn Steven E
Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide.
Diabetes 2005;54(7):2235-44.
2005: Hull R L; Kodama K; Utzschneider K M; Carr D B; Prigeon R L; Kahn S E
Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation.
Diabetologia 2005;48(7):1350-8.
2005: Tannock Lisa R; O'Brien Kevin D; Knopp Robert H; Retzlaff Barbara; Fish Brian; Wener Mark H; Kahn Steven E; Chait Alan
Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjects.
Circulation 2005;111(23):3058-62.
2005: Tong Jenny; Fujimoto Wilfred Y; Kahn Steven E; Weigle David S; McNeely Marguerite J; Leonetti Donna L; Shofer Jane B; Boyko Edward J
Insulin, C-peptide, and leptin concentrations predict increased visceral adiposity at 5- and 10-year follow-ups in nondiabetic Japanese Americans.
Diabetes 2005;54(4):985-90.
2005: Carr Darcy B; Utzschneider Kristina M; Boyko Edward J; Asberry Pamela J; Hull Rebecca L; Kodama Keiichi; Callahan Holly S; Matthys Colleen C; Leonetti Donna L; Schwartz Robert S; Kahn Steven E; Fujimoto Wilfred Y
A reduced-fat diet and aerobic exercise in Japanese Americans with impaired glucose tolerance decreases intra-abdominal fat and improves insulin sensitivity but not beta-cell function.
Diabetes 2005;54(2):340-7.
2004: Zinman Bernard; Kahn Steven E; Haffner Steven M; O'Neill M Colleen; Heise Mark A; Freed Martin I;
Phenotypic characteristics of GAD antibody-positive recently diagnosed patients with type 2 diabetes in North America and Europe.
Diabetes 2004;53(12):3193-200.
2004: Røder Michael E; Kahn Steven E
Suppression of Beta-cell secretion by somatostatin does not fully reverse the disproportionate proinsulinemia of type 2 diabetes.
Diabetes 2004;53 Suppl 3():S22-5.
2004: Utzschneider Kristina M; Carr Darcy B; Hull Rebecca L; Kodama Keiichi; Shofer Jane B; Retzlaff Barbara M; Knopp Robert H; Kahn Steven E
Impact of intra-abdominal fat and age on insulin sensitivity and beta-cell function.
Diabetes 2004;53(11):2867-72.
2004: Hull Rebecca L; Westermark Gunilla T; Westermark Per; Kahn Steven E
Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2004;89(8):3629-43.
2004: Carr Darcy B; Utzschneider Kristina M; Hull Rebecca L; Kodama Keiichi; Retzlaff Barbara M; Brunzell John D; Shofer Jane B; Fish Brian E; Knopp Robert H; Kahn Steven E
Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome.
Diabetes 2004;53(8):2087-94.
2004: Hayashi Tomoshige; Boyko Edward J; Leonetti Donna L; McNeely Marguerite J; Newell-Morris Laura; Kahn Steven E; Fujimoto Wilfred Y
Visceral adiposity is an independent predictor of incident hypertension in Japanese Americans.
Annals of internal medicine 2004;140(12):992-1000.
2004: Utzschneider Kristina M; Carr Darcy B; Barsness Suzanne M; Kahn Steven E; Schwartz Robert S
Diet-induced weight loss is associated with an improvement in beta-cell function in older men.
The Journal of clinical endocrinology and metabolism 2004;89(6):2704-10.
2004: Kahn Steven E
Engineering a new beta-cell: a critical venture requiring special attention to constantly changing physiological needs.
Seminars in cell & developmental biology 2004;15(3):359-70.
2004: Pajvani Utpal B; Hawkins Meredith; Combs Terry P; Rajala Michael W; Doebber Tom; Berger Joel P; Wagner John A; Wu Margaret; Knopps Annemie; Xiang Anny H; Utzschneider Kristina M; Kahn Steven E; Olefsky Jerrold M; Buchanan Thomas A; Scherer Philipp E
Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity.
The Journal of biological chemistry 2004;279(13):12152-62.
2004: Andrikopoulos Sofianos; Hull Rebecca L; Verchere C Bruce; Wang Feng; Wilbur Shani M; Wight Thomas N; Marzban Lucy; Kahn Steven E
Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide.
American journal of physiology. Endocrinology and metabolism 2004;286(3):E418-24.
2003: Hayashi Tomoshige; Boyko Edward J; Leonetti Donna L; McNeely Marguerite J; Newell-Morris Laura; Kahn Steven E; Fujimoto Wilfred Y
Visceral adiposity and the prevalence of hypertension in Japanese Americans.
Circulation 2003;108(14):1718-23.
2003: Murdoch Susan J; Kahn Steven E; Albers John J; Brunzell John D; Purnell Jonathan Q
PLTP activity decreases with weight loss: changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity.
Journal of lipid research 2003;44(9):1705-12.
2003: Knopp Robert H; Retzlaff Barbara; Fish Brian; Walden Carolyn; Wallick Shari; Anderson Melissa; Aikawa Keiko; Kahn Steven E
Effects of insulin resistance and obesity on lipoproteins and sensitivity to egg feeding.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(8):1437-43.
2003: Potter-Perigo Susan; Hull Rebecca L; Tsoi Christina; Braun Kathleen R; Andrikopoulos Sofianos; Teague Jeanette; Bruce Verchere C; Kahn Steven E; Wight Thomas N
Proteoglycans synthesized and secreted by pancreatic islet beta-cells bind amylin.
Archives of biochemistry and biophysics 2003;413(2):182-90.
2003: Cnop M; Havel P J; Utzschneider K M; Carr D B; Sinha M K; Boyko E J; Retzlaff B M; Knopp R H; Brunzell J D; Kahn S E
Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex.
Diabetologia 2003;46(4):459-69.
2003: Knopp Robert H; Retzlaff Barbara; Aikawa Keiko; Kahn Steven E
Management of patients with diabetic hyperlipidemia.
The American journal of cardiology 2003;91(7A):24E-28E.
2003: McNeely Marguerite J; Boyko Edward J; Leonetti Donna L; Kahn Steven E; Fujimoto Wilfred Y
Comparison of a clinical model, the oral glucose tolerance test, and fasting glucose for prediction of type 2 diabetes risk in Japanese Americans.
Diabetes care 2003;26(3):758-63.
2003: Hayashi Tomoshige; Boyko Edward J; Leonetti Donna L; McNeely Marguerite J; Newell-Morris Laura; Kahn Steven E; Fujimoto Wilfred Y
Visceral adiposity and the risk of impaired glucose tolerance: a prospective study among Japanese Americans.
Diabetes care 2003;26(3):650-5.
2003: Hull Rebecca L; Andrikopoulos Sofianos; Verchere C Bruce; Vidal Josep; Wang Feng; Cnop Miriam; Prigeon Ronald L; Kahn Steven E
Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid.
Diabetes 2003;52(2):372-9.
2003: Vidal J; Verchere C Bruce; Andrikopoulos S; Wang F; Hull R L; Cnop M; Olin K L; LeBoeuf R C; O'Brien K D; Chait A; Kahn S E
The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice.
Diabetologia 2003;46(1):71-9.
2003: Kahn S E
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes.
Diabetologia 2003;46(1):3-19.
2003: Nieves Delma J; Cnop Miriam; Retzlaff Barbara; Walden Carolyn E; Brunzell John D; Knopp Robert H; Kahn Steven E
The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat.
Diabetes 2003;52(1):172-9.
2002: Viberti Giancarlo; Kahn Steven E; Greene Douglas A; Herman William H; Zinman Bernard; Holman Rury R; Haffner Steven M; Levy Daniel; Lachin John M; Berry Rhona A; Heise Mark A; Jones Nigel P; Freed Martin I
A diabetes outcome progression trial (ADOPT): an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetes.
Diabetes care 2002;25(10):1737-43.
2002: Liao David; Asberry Pamela J; Shofer Jane B; Callahan Holly; Matthys Colleen; Boyko Edward J; Leonetti Donna; Kahn Steven E; Austin Melissa; Newell Laura; Schwartz Robert S; Fujimoto Wilfred Y
Improvement of BMI, body composition, and body fat distribution with lifestyle modification in Japanese Americans with impaired glucose tolerance.
Diabetes care 2002;25(9):1504-10.
2002: Jensen Christine C; Cnop Miriam; Hull Rebecca L; Fujimoto Wilfred Y; Kahn Steven E;
Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S.
Diabetes 2002;51(7):2170-8.
2002: Cnop Miriam; Landchild Melinda J; Vidal Josep; Havel Peter J; Knowles Negar G; Carr Darcy R; Wang Feng; Hull Rebecca L; Boyko Edward J; Retzlaff Barbara M; Walden Carolyn E; Knopp Robert H; Kahn Steven E
The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments.
Diabetes 2002;51(4):1005-15.
2002: Knowles Negar G; Landchild Melinda A; Fujimoto Wilfred Y; Kahn Steven E
Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes.
Diabetes care 2002;25(2):292-7.
2002: Sweet Ian R; Khalil Gamal; Wallen Angela R; Steedman Mark; Schenkman Kenneth A; Reems Jo Anna; Kahn Steven E; Callis James B
Continuous measurement of oxygen consumption by pancreatic islets.
Diabetes technology & therapeutics 2002;4(5):661-72.
2001: Kahn S E; Montgomery B; Howell W; Ligueros-Saylan M; Hsu C H; Devineni D; McLeod J F; Horowitz A; Foley J E
Importance of early phase insulin secretion to intravenous glucose tolerance in subjects with type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2001;86(12):5824-9.
2001: Wang F; Hull R L; Vidal J; Cnop M; Kahn S E
Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.
Diabetes 2001;50(11):2514-20.
2001: Kahn S E
Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2001;86(9):4047-58.
2001: Purnell J Q; Kahn S E; Schwartz R S; Brunzell J D
Relationship of insulin sensitivity and ApoB levels to intra-abdominal fat in subjects with familial combined hyperlipidemia.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(4):567-72.
2001: Hull R L; Verchere C B; Andrikopoulos S; Wang F; Vidal J; Kahn S E
Oophorectomy promotes islet amyloid formation in human islet amyloid polypeptide transgenic mice.
Diabetes 2001;50 Suppl 1():S184-5.
2001: Kahn S E; Prigeon R L; Schwartz R S; Fujimoto W Y; Knopp R H; Brunzell J D; Porte D
Obesity, body fat distribution, insulin sensitivity and Islet beta-cell function as explanations for metabolic diversity.
The Journal of nutrition 2001;131(2):354S-60S.
2001: Liao D; Shofer J B; Boyko E J; McNeely M J; Leonetti D L; Kahn S E; Fujimoto W Y
Abnormal glucose tolerance and increased risk for cardiovascular disease in Japanese-Americans with normal fasting glucose.
Diabetes care 2001;24(1):39-44.
2000: Fujimoto W Y; Bergstrom R W; Boyko E J; Chen K W; Kahn S E; Leonetti D L; McNeely M J; Newell L L; Shofer J B; Tsunehara C H; Wahl P W
Preventing diabetes--applying pathophysiological and epidemiological evidence.
The British journal of nutrition 2000;84 Suppl 2():S173-6.
2000: Andrikopoulos S; Verchere C B; Terauchi Y; Kadowaki T; Kahn S E
beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.
Diabetes 2000;49(12):2056-62.
2000: Kahn S E; Andrikopoulos S; Verchere C B; Wang F; Hull R L; Vidal J
Oophorectomy promotes islet amyloid formation in a transgenic mouse model of Type II diabetes.
Diabetologia 2000;43(10):1309-12.
2000: Fujimoto W Y; Bergstrom R W; Boyko E J; Chen K; Kahn S E; Leonetti D L; McNeely M J; Newell L L; Shofer J B; Wahl P W
Type 2 diabetes and the metabolic syndrome in Japanese Americans.
Diabetes research and clinical practice 2000;50 Suppl 2():S73-6.
2000: Kaiyala K J; Prigeon R L; Kahn S E; Woods S C; Schwartz M W
Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs.
Diabetes 2000;49(9):1525-33.
2000: Verchere C B; D'Alessio D A; Prigeon R L; Hull R L; Kahn S E
The constitutive secretory pathway is a major route for islet amyloid polypeptide secretion in neonatal but not adult rat islet cells.
Diabetes 2000;49(9):1477-84.
2000: Røder M E; Schwartz R S; Prigeon R L; Kahn S E
Reduced pancreatic B cell compensation to the insulin resistance of aging: impact on proinsulin and insulin levels.
The Journal of clinical endocrinology and metabolism 2000;85(6):2275-80.
2000: Purnell J Q; Kahn S E; Albers J J; Nevin D N; Brunzell J D; Schwartz R S
Effect of weight loss with reduction of intra-abdominal fat on lipid metabolism in older men.
The Journal of clinical endocrinology and metabolism 2000;85(3):977-82.
1999: Kaiyala K J; Prigeon R L; Kahn S E; Woods S C; Porte D; Schwartz M W
Reduced beta-cell function contributes to impaired glucose tolerance in dogs made obese by high-fat feeding.
The American journal of physiology 1999;277(4 Pt 1):E659-67.
1999: Andrikopoulos S; Verchere C B; Teague J C; Howell W M; Fujimoto W Y; Wight T N; Kahn S E
Two novel immortal pancreatic beta-cell lines expressing and secreting human islet amyloid polypeptide do not spontaneously develop islet amyloid.
Diabetes 1999;48(10):1962-70.
1999: Kahn S E; Andrikopoulos S; Verchere C B
Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.
Diabetes 1999;48(2):241-53.
1999: Greenbaum C J; Sears K L; Kahn S E; Palmer J P
Relationship of beta-cell function and autoantibodies to progression and nonprogression of subclinical type 1 diabetes: follow-up of the Seattle Family Study.
Diabetes 1999;48(1):170-5.
1998: Dechenes C J; Verchere C B; Andrikopoulos S; Kahn S E
Human aging is associated with parallel reductions in insulin and amylin release.
The American journal of physiology 1998;275(5 Pt 1):E785-91.
1998: Kahn S E; Verchere C B; Andrikopoulos S; Asberry P J; Leonetti D L; Wahl P W; Boyko E J; Schwartz R S; Newell-Morris L; Fujimoto W Y
Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans.
Diabetes 1998;47(4):640-5.
1998: Prigeon R L; Kahn S E; Porte D
Effect of troglitazone on B cell function, insulin sensitivity, and glycemic control in subjects with type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1998;83(3):819-23.
1998: Røder M E; Porte D; Schwartz R S; Kahn S E
Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1998;83(2):604-8.
1997: Ensinck J W; Vogel R E; Laschansky E C; Koerker D J; Prigeon R L; Kahn S E; D'Alessio D A
Endogenous somatostatin-28 modulates postprandial insulin secretion. Immunoneutralization studies in baboons.
The Journal of clinical investigation 1997;100(9):2295-302.
1997: Kahn S E; Halban P A
Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM.
Diabetes 1997;46(11):1725-32.
1997: Schwartz M W; Prigeon R L; Kahn S E; Nicolson M; Moore J; Morawiecki A; Boyko E J; Porte D
Evidence that plasma leptin and insulin levels are associated with body adiposity via different mechanisms.
Diabetes care 1997;20(9):1476-81.
1996: Verchere C B; Paoletta M; Neerman-Arbez M; Rose K; Irminger J C; Gingerich R L; Kahn S E; Halban P A
Des-(27-31)C-peptide. A novel secretory product of the rat pancreatic beta cell produced by truncation of proinsulin connecting peptide in secretory granules.
The Journal of biological chemistry 1996;271(44):27475-81.
1996: Greenbaum C J; Kahn S E; Palmer J P
Nicotinamide's effects on glucose metabolism in subjects at risk for IDDM.
Diabetes 1996;45(11):1631-4.
1996: Kahn S E; Leonetti D L; Prigeon R L; Boyko E J; Bergstom R W; Fujimoto W Y
Proinsulin levels predict the development of non-insulin-dependent diabetes mellitus (NIDDM) in Japanese-American men.
Diabetic medicine : a journal of the British Diabetic Association 1996;13(9 Suppl 6):S63-6.
1996: Prigeon R L; Jacobson R K; Porte D; Kahn S E
Effect of sulfonylurea withdrawal on proinsulin levels, B cell function, and glucose disposal in subjects with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1996;81(9):3295-8.
1996: Verchere C B; D'Alessio D A; Palmiter R D; Weir G C; Bonner-Weir S; Baskin D G; Kahn S E
Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3492-6.
1996: Stone L M; Kahn S E; Fujimoto W Y; Deeb S S; Porte D
A variation at position -30 of the beta-cell glucokinase gene promoter is associated with reduced beta-cell function in middle-aged Japanese-American men.
Diabetes 1996;45(4):422-8.
1996: Prigeon R L; Røder M E; Porte D; Kahn S E
The effect of insulin dose on the measurement of insulin sensitivity by the minimal model technique. Evidence for saturable insulin transport in humans.
The Journal of clinical investigation 1996;97(2):501-7.
1996: Baura G D; Foster D M; Kaiyala K; Porte D; Kahn S E; Schwartz M W
Insulin transport from plasma into the central nervous system is inhibited by dexamethasone in dogs.
Diabetes 1996;45(1):86-90.
1995: Prigeon R L; Kahn S E; Porte D
Changes in insulin sensitivity, glucose effectiveness, and B-cell function in regularly exercising subjects.
Metabolism: clinical and experimental 1995;44(10):1259-63.
1995: Schwartz M W; Boyko E J; Kahn S E; Ravussin E; Bogardus C
Reduced insulin secretion: an independent predictor of body weight gain.
The Journal of clinical endocrinology and metabolism 1995;80(5):1571-6.
1995: Kahn S E; Leonetti D L; Prigeon R L; Boyko E J; Bergstrom R W; Fujimoto W Y
Relationship of proinsulin and insulin with noninsulin-dependent diabetes mellitus and coronary heart disease in Japanese-American men: impact of obesity--clinical research center study.
The Journal of clinical endocrinology and metabolism 1995;80(4):1399-406.
1995: Kahn S E; Leonetti D L; Prigeon R L; Boyko E J; Bergstrom R W; Fujimoto W Y
Proinsulin as a marker for the development of NIDDM in Japanese-American men.
Diabetes 1995;44(2):173-9.
1994: D'Alessio D A; Verchere C B; Kahn S E; Hoagland V; Baskin D G; Palmiter R D; Ensinck J W
Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.
Diabetes 1994;43(12):1457-61.
1994: Stone L M; Kahn S E; Deeb S S; Fujimoto W Y; Porte D
Glucokinase gene variations in Japanese-Americans with a family history of NIDDM.
Diabetes care 1994;17(12):1480-3.
1994: Fujimoto W Y; Abbate S L; Kahn S E; Hokanson J E; Brunzell J D
The visceral adiposity syndrome in Japanese-American men.
Obesity research 1994;2(4):364-71.
1994: Verchere C B; D'Alessio D A; Palmiter R D; Kahn S E
Transgenic mice overproducing islet amyloid polypeptide have increased insulin storage and secretion in vitro.
Diabetologia 1994;37(7):725-8.
1994: D'Alessio D A; Kahn S E; Leusner C R; Ensinck J W
Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal.
The Journal of clinical investigation 1994;93(5):2263-6.
1994: Kahn S E; Prigeon R L; McCulloch D K; Boyko E J; Bergman R N; Schwartz M W; Neifing J L; Ward W K; Beard J C; Palmer J P
The contribution of insulin-dependent and insulin-independent glucose uptake to intravenous glucose tolerance in healthy human subjects.
Diabetes 1994;43(4):587-92.
1994: Prigeon R L; Kahn S E; Porte D
Reliability of error estimates from the minimal model: implications for measurements in physiological studies.
The American journal of physiology 1994;266(2 Pt 1):E279-86.
1993: Kahn S E; Prigeon R L; McCulloch D K; Boyko E J; Bergman R N; Schwartz M W; Neifing J L; Ward W K; Beard J C; Palmer J P
Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function.
Diabetes 1993;42(11):1663-72.
1993: Baura G D; Foster D M; Porte D; Kahn S E; Bergman R N; Cobelli C; Schwartz M W
Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.
The Journal of clinical investigation 1993;92(4):1824-30.
1993: Kahn S E; Horber F F; Prigeon R L; Haymond M W; Porte D
Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans.
Diabetes 1993;42(7):1082-5.
1993: Kahn S E; Verchere C B; D'Alessio D A; Cook D L; Fujimoto W Y
Evidence for selective release of rodent islet amyloid polypeptide through the constitutive secretory pathway.
Diabetologia 1993;36(6):570-3.
1993: Neifing J L; Greenbaum C J; Kahn S E; McCulloch D K; Barmeier H; Lernmark A; Palmer J P
Prospective evaluation of beta-cell function in insulin autoantibody-positive relatives of insulin-dependent diabetic patients.
Metabolism: clinical and experimental 1993;42(4):482-6.
1993: Abbate S L; Fujimoto W Y; Brunzell J D; Kahn S E
Effect of heparin on insulin-glucose interactions measured by the minimal model technique: implications for reproducibility using this method.
Metabolism: clinical and experimental 1993;42(3):353-7.
1992: Stratton J R; Cerqueira M D; Schwartz R S; Levy W C; Veith R C; Kahn S E; Abrass I B
Differences in cardiovascular responses to isoproterenol in relation to age and exercise training in healthy men.
Circulation 1992;86(2):504-12.
1992: Schwartz R S; Cain K C; Shuman W P; Larson V; Stratton J R; Beard J C; Kahn S E; Cerqueira M D; Abrass I B
Effect of intensive endurance training on lipoprotein profiles in young and older men.
Metabolism: clinical and experimental 1992;41(6):649-54.
1992: Schwartz M W; Sipols A J; Marks J L; Sanacora G; White J D; Scheurink A; Kahn S E; Baskin D G; Woods S C; Figlewicz D P
Inhibition of hypothalamic neuropeptide Y gene expression by insulin.
Endocrinology 1992;130(6):3608-16.
1992: Chandler W L; Veith R C; Fellingham G W; Levy W C; Schwartz R S; Cerqueira M D; Kahn S E; Larson V G; Cain K C; Beard J C
Fibrinolytic response during exercise and epinephrine infusion in the same subjects.
Journal of the American College of Cardiology 1992;19(7):1412-20.
1992: Kahn S E; Larson V G; Schwartz R S; Beard J C; Cain K C; Fellingham G W; Stratton J R; Cerqueira M D; Abrass I B
Exercise training delineates the importance of B-cell dysfunction to the glucose intolerance of human aging.
The Journal of clinical endocrinology and metabolism 1992;74(6):1336-42.
1992: Kahn S E; Bergman R N; Schwartz M W; Taborsky G J; Porte D
Short-term hyperglycemia and hyperinsulinemia improve insulin action but do not alter glucose action in normal humans.
The American journal of physiology 1992;262(4 Pt 1):E518-23.
1992: Kahn S E; McCulloch D K; Schwartz M W; Palmer J P; Porte D
Effect of insulin resistance and hyperglycemia on proinsulin release in a primate model of diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1992;74(1):192-7.
1991: Kahn S E; Fujimoto W Y; D'Alessio D A; Ensinck J W; Porte D
Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1991;23(12):577-80.
1991: Schwartz M W; Bergman R N; Kahn S E; Taborsky G J; Fisher L D; Sipols A J; Woods S C; Steil G M; Porte D
Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport.
The Journal of clinical investigation 1991;88(4):1272-81.
1991: McCulloch D K; Koerker D J; Kahn S E; Bonner-Weir S; Palmer J P
Correlations of in vivo beta-cell function tests with beta-cell mass and pancreatic insulin content in streptozocin-administered baboons.
Diabetes 1991;40(6):673-9.
1991: Porte D; Kahn S E
Mechanisms for hyperglycemia in type II diabetes mellitus: therapeutic implications for sulfonylurea treatment--an update.
The American journal of medicine 1991;90(6A):8S-14S.
1991: Schwartz R S; Shuman W P; Larson V; Cain K C; Fellingham G W; Beard J C; Kahn S E; Stratton J R; Cerqueira M D; Abrass I B
The effect of intensive endurance exercise training on body fat distribution in young and older men.
Metabolism: clinical and experimental 1991;40(5):545-51.
1991: Schwartz M W; Marks J L; Sipols A J; Baskin D G; Woods S C; Kahn S E; Porte D
Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats.
Endocrinology 1991;128(5):2645-7.
1991: Stratton J R; Chandler W L; Schwartz R S; Cerqueira M D; Levy W C; Kahn S E; Larson V G; Cain K C; Beard J C; Abrass I B
Effects of physical conditioning on fibrinolytic variables and fibrinogen in young and old healthy adults.
Circulation 1991;83(5):1692-7.
1991: Kahn S E; Schwartz R S; Porte D; Abrass I B
The glucose intolerance of aging. Implications for intervention.
Hospital practice (Office ed.) 1991;26(4A):29-38.
1991: McCulloch D K; Kahn S E; Schwartz M W; Koerker D J; Palmer J P
Effect of nicotinic acid-induced insulin resistance on pancreatic B cell function in normal and streptozocin-treated baboons.
The Journal of clinical investigation 1991;87(4):1395-401.
1990: Schwartz R S; Shuman W P; Bradbury V L; Cain K C; Fellingham G W; Beard J C; Kahn S E; Stratton J R; Cerqueira M D; Abrass I B
Body fat distribution in healthy young and older men.
Journal of gerontology 1990;45(6):M181-5.
1990: Kahn S E; Klaff L J; Schwartz M W; Beard J C; Bergman R N; Taborsky G J; Porte D
Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose.
The Journal of clinical endocrinology and metabolism 1990;71(4):994-1002.
1990: Schwartz M W; Sipols A; Kahn S E; Lattemann D F; Taborsky G J; Bergman R N; Woods S C; Porte D
Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid.
The American journal of physiology 1990;259(3 Pt 1):E378-83.
1990: Kahn S E; Larson V G; Beard J C; Cain K C; Fellingham G W; Schwartz R S; Veith R C; Stratton J R; Cerqueira M D; Abrass I B
Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging.
The American journal of physiology 1990;258(6 Pt 1):E937-43.
1990: Schwartz M W; Figlewicz D F; Kahn S E; Baskin D G; Greenwood M R; Porte D
Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats.
Peptides 1990;11(3):467-72.
1990: Kahn S E; D'Alessio D A; Schwartz M W; Fujimoto W Y; Ensinck J W; Taborsky G J; Porte D
Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells.
Diabetes 1990;39(5):634-8.
1990: McCulloch D K; Klaff L J; Kahn S E; Schoenfeld S L; Greenbaum C J; Mauseth R S; Benson E A; Nepom G T; Shewey L; Palmer J P
Nonprogression of subclinical beta-cell dysfunction among first-degree relatives of IDDM patients. 5-yr follow-up of the Seattle Family Study.
Diabetes 1990;39(5):549-56.
1989: Porte D; Kahn S E
Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet beta-cell dysfunction?
Diabetes 1989;38(11):1333-6.
1989: Kahn S E; Beard J C; Schwartz M W; Ward W K; Ding H L; Bergman R N; Taborsky G J; Porte D
Increased beta-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance.
Diabetes 1989;38(5):562-8.
1988: Kahn S E; Porte D
Islet dysfunction in non-insulin-dependent diabetes mellitus.
The American journal of medicine 1988;85(5A):4-8.
1988: McCulloch D K; Raghu P K; Johnston C; Klaff L J; Kahn S E; Beard J C; Ward W K; Benson E A; Koerker D J; Bergman R N
Defects in beta-cell function and insulin sensitivity in normoglycemic streptozocin-treated baboons: a model of preclinical insulin-dependent diabetes.
The Journal of clinical endocrinology and metabolism 1988;67(4):785-92.

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