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Kozo Kaibuchi

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Daisuke Ibi; Kozo Kaibuchi; Shin-Ichi Kano; Takahiro Kawase; Ulrike C Lange; Hiroyuki Mizoguchi; Toshitaka Nabeshima; Taku Nagai; Akira Nakajima; Yoshiaki Sato; Takaya Satoh; Akira Sawa; M Azim Surani; Daisuke Tsuboi; David J Adams; Masahiro Hayakawa; Kiyofumi Yamada
Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.
Branko Aleksic; Motoyuki Fukumoto; Yasuhisa Fukuo; Ryota Hashimoto; Masashi Ikeda; Toshiya Inada; Yoshihito Ito; Nakao Iwata; Kozo Kaibuchi; Itaru Kushima; Yukako Nakamura; Kazutaka Ohi; Tomo Okochi; Michio Suzuki; Masatoshi Takeda; Hiroshi Ujike; Hidenaga Yamamori; Yuka Yasuda; Akira Yoshimi; Norio Ozaki
Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel-based morphometry and mutation screening.
Mikito Takefuji; Kozo Kaibuchi; Marcus Krüger; Stefan Offermanns; Kishor K Sivaraj; Nina Wettschureck
RhoGEF12 controls cardiac remodeling by integrating G protein- and integrin-dependent signaling cascades.

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All Publications

2013: Daisuke Ibi; Kozo Kaibuchi; Shin-Ichi Kano; Takahiro Kawase; Ulrike C Lange; Hiroyuki Mizoguchi; Toshitaka Nabeshima; Taku Nagai; Akira Nakajima; Yoshiaki Sato; Takaya Satoh; Akira Sawa; M Azim Surani; Daisuke Tsuboi; David J Adams; Masahiro Hayakawa; Kiyofumi Yamada
Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.
Glia 2013;61(5):679-93.
2013: Branko Aleksic; Motoyuki Fukumoto; Yasuhisa Fukuo; Ryota Hashimoto; Masashi Ikeda; Toshiya Inada; Yoshihito Ito; Nakao Iwata; Kozo Kaibuchi; Itaru Kushima; Yukako Nakamura; Kazutaka Ohi; Tomo Okochi; Michio Suzuki; Masatoshi Takeda; Hiroshi Ujike; Hidenaga Yamamori; Yuka Yasuda; Akira Yoshimi; Norio Ozaki
Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel-based morphometry and mutation screening.
Schizophrenia bulletin 2013;39(3):720-8.
2013: Mikito Takefuji; Kozo Kaibuchi; Marcus Krüger; Stefan Offermanns; Kishor K Sivaraj; Nina Wettschureck
RhoGEF12 controls cardiac remodeling by integrating G protein- and integrin-dependent signaling cascades.
The Journal of experimental medicine 2013;210(4):665-73.
2013: Chunsheng Liu; Vijay H Shah; Liu Yang; Edward Leof; Haitham Abdelhakim; Carmelo Bernabeu; Daniel D Billadeau; George S Bloom; Lisa Boardman; Kozo Kaibuchi; Ningling Kang
IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver.
The Journal of clinical investigation 2013;123(3):1138-56.
2013: Masanori Nakayama; Shigeo Ohno; Max van Lessen; Dietmar Vestweber; Hiroyuki Yamamoto; Georg Breier; Jonathan A Cooper; Hannes C A Drexler; Tomonori Hirose; Sarah Hoffmann; Norimichi Itoh; Kozo Kaibuchi; Akiko Nakayama; Ralf H Adams
Spatial regulation of VEGF receptor endocytosis in angiogenesis.
Nature cell biology 2013;15(3):249-60.
2013: Jaesuk Yun; Yoko Furukawa-Hibi; Michael E Greenberg; Kozo Kaibuchi; Keisuke Kuroda; Taku Nagai; Kiyofumi Yamada
Neuronal Per Arnt Sim (PAS) domain protein 4 (NPAS4) regulates neurite outgrowth and phosphorylation of synapsin I.
The Journal of biological chemistry 2013;288(4):2655-64.
2012: Wenjing Li; Takashi Moriwaki; Tomomi Tani; Takashi Watanabe; Kozo Kaibuchi; Gohta Goshima
Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin.
The Journal of cell biology 2012;199(5):849-62.
2012: Katsuhiro Kato; Mutsuki Amano; Kozo Kaibuchi
[Small GTPases and their effectors].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 8():67-70.
2012: Shujie Wang; Takashi Watanabe; Feng Ye; John G Collard; Mark H Ginsberg; Mai Kakeno; Akira Katsumi; Kazushi Kimura; Toshinori Matsui; Kenji Matsuzawa; Akira Mizoguchi; Kiyoko Murase; Kazuhide Sato; Ikuko Sugiyama; Kozo Kaibuchi
Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration.
The Journal of cell biology 2012;199(2):331-45.
2012: Katsuhiro Kato; Yoshiharu Matsuura; Kazutaka Mori; Toyoaki Murohara; Tomoki Nishioka; Tadaomi Takenawa; Kentaro Taki; Shujie Wang; Tsubasa Yazawa; Mutsuki Amano; Tomonari Hamaguchi; Toshiki Itoh; Chikako Kataoka; Kozo Kaibuchi
The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.
Molecular biology of the cell 2012;23(13):2593-604.
2012: Tatsuyuki Chiyoda; Yasushi Ishihama; Jo Ishizawa; Masaaki Ito; Kozo Kaibuchi; Yusuke Kobayashi; Hideaki Naoe; Hideyuki Saya; Takatsune Shimizu; Naoyuki Sugiyama; Hiroshi Tsuda; Daisuke Aoki; Yoshimi Arima; Shinji Kuninaka
LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression.
The Journal of cell biology 2012;197(5):625-41.
2012: Kanako Watanabe; Katsuyuki Yugi; Shinichi Nakamuta; Shinsuke Uda; Yuki Akimoto; Jaehoon Chung; Kozo Kaibuchi; Shinya Kuroda
Latent process genes for cell differentiation are common decoders of neurite extension length.
Journal of cell science 2012;125(Pt 9):2198-211.
2012: Itaru Kushima; Yukako Nakamura; Tomo Okochi; Tomoko Shiino; Michio Suzuki; Masatoshi Takeda; Hiroshi Ujike; Branko Aleksic; Yasuhisa Fukuo; Ryota Hashimoto; Masashi Ikeda; Toshiya Inada; Yoshihito Ito; Nakao Iwata; Kozo Kaibuchi; Norio Ozaki
Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility.
Schizophrenia bulletin 2012;38(3):552-60.
2012: Masashi Okada; Matthew K Topham; Takashi Watanabe; Hitoshi Yagisawa; Mitsuaki Yanagida; Yasukazu Hozumi; Kiyoshi Iwazaki; Kozo Kaibuchi; Kentaro Misaki; Yoshihiko Araki; Kaoru Goto
DGKζ is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway.
Biochemical and biophysical research communications 2012;420(2):479-84.
2012: Michiro Iizuka; Kozo Kaibuchi; Katsuhiro Kato; Kazushi Kimura; Mutsuki Amano; Shujie Wang; Akira Mizoguchi
Distinct distribution and localization of Rho-kinase in mouse epithelial, muscle and neural tissues.
Cell structure and function 2012;37(2):155-75.
2012: Maki Ishida-Takagishi; Kozo Kaibuchi; Takuya Kato; Akira Kikuchi; Shinji Matsumoto; Yoshiki Murakumo; Masato Asai; Naoya Asai; Atsushi Enomoto; Takahiko Hashimoto; Kaori Ushida; Takashi Watanabe; Liang Weng; Masahide Takahashi
The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility.
Nature communications 2012;3():859.
2012: Kei Ohara; Takashi Watanabe; Liang Weng; Naoya Asai; Atsushi Enomoto; Hidemi Goto; Takahiko Hashimoto; Yoshiki Hirooka; Maki Ishida-Takagishi; Mayu Isotani-Sakakibara; Kozo Kaibuchi; Katsuhiro Kato; Takuya Kato; Yoshiki Murakumo; Masanori Nakayama; Masahide Takahashi
Involvement of Girdin in the determination of cell polarity during cell migration.
PloS one 2012;7(5):e36681.
2012: Tomoki Nishioka; Masanori Nakayama; Mutsuki Amano; Kozo Kaibuchi
Proteomic screening for Rho-kinase substrates by combining kinase and phosphatase inhibitors with 14-3-3ζ affinity chromatography.
Cell structure and function 2012;37(1):39-48.
2011: Keisuke Kuroda; Akira Mizoguchi; Daisuke Mori; Taku Nagai; Takashi Namba; Tomoki Nishioka; Masahiro Sokabe; Masahide Takahashi; Motoki Tanaka; Daisuke Tsuboi; Rui Wang; Kiyofumi Yamada; Shinnosuke Yamada; Hisashi Yano; Takaya Abe; Naoya Asai; Atsushi Enomoto; Daisuke Ibi; Michiro Iizuka; Yukihiko Iizuka; Mayu Isotani-Sakakibara; Kazushi Kimura; Hiroshi Kiyonari; Shimpei Kubota; Kozo Kaibuchi
Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.
Human molecular genetics 2011;20(23):4666-83.
2011: Francois Renault-Mihara; Ken Saito; Shinsuke Shibata; Hirobumi Tada; Yoshiaki Toyama; Akimasa Yasuda; Takeshi Ikegami; Akio Iwanami; Kozo Kaibuchi; Hiroyuki Katoh; Yo Mabuchi; Masayuki Matsushita; Masahiko Mukaino; Masaya Nakamura; Satoshi Nori; Seiji Okada; Hideyuki Okano
Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition.
EMBO molecular medicine 2011;3(11):682-96.
2011: Kazuhide Sato; Ikuko Sugiyama; Shujie Wang; Takashi Watanabe; Keiko Yokoi; Mai Kakeno; Toshinori Matsui; Kenji Matsuzawa; Kiyoko Murase; Masayuki Ozawa; Kozo Kaibuchi
Numb controls E-cadherin endocytosis through p120 catenin with aPKC.
Molecular biology of the cell 2011;22(17):3103-19.
2011: Takashi Namba; Hongjun Song; Chikako Waga; Atsushi Enomoto; Kozo Kaibuchi; Shinichi Kohsaka; Guo-Li Ming; Shigeo Uchino
NMDA receptor regulates migration of newly generated neurons in the adult hippocampus via Disrupted-In-Schizophrenia 1 (DISC1).
Journal of neurochemistry 2011;118(1):34-44.
2011: Chittaranjan Routray; Vijay H Shah; Usman Yaqoob; Chunsheng Liu; Daniel D Billadeau; Kenneth D Bloch; Kozo Kaibuchi; Ningling Kang
Protein kinase G signaling disrupts Rac1-dependent focal adhesion assembly in liver specific pericytes.
American journal of physiology. Cell physiology 2011;301(1):C66-74.
2011: Saori Takeda; Takashi Watanabe; Emiko Yamauchi; Takeshi Ohta; Ai Fujimoto; Mineyoshi Hiyoshi; Kozo Kaibuchi; Hiroshi Kido; Hiroaki Konishi
Role of a tyrosine phosphorylation of SMG-9 in binding of SMG-9 to IQGAP and the NMD complex.
Biochemical and biophysical research communications 2011;410(1):29-33.
2011: Wenjing Li; Tomohiro Miki; Ikuko Sugiyama; Takashi Watanabe; Kozo Kaibuchi; Mai Kakeno; Gohta Goshima
EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells.
The Journal of cell biology 2011;193(6):973-83.
2011: Yun Wang; Masato Asai; Naoya Asai; Atsushi Enomoto; Takao Hikita; Mayu Isotani-Sakakibara; Kozo Kaibuchi; Naoko Kaneko; Takuya Kato; Keisuke Kuroda; Guo-Li Ming; Yoshiki Murakumo; Takashi Namba; Haruko Ota; Kazunobu Sawamoto; Hongjun Song; Masahide Takahashi
Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(22):8109-22.
2011: Chris Q Doe; Kozo Kaibuchi
Neuronal polarity in 2011.
Developmental neurobiology 2011;71(6):401-2.
2011: Takashi Namba; Shinichi Nakamuta; Yasuhiro Funahashi; Kozo Kaibuchi
The role of selective transport in neuronal polarization.
Developmental neurobiology 2011;71(6):445-57.
2011: Hirotaka Sekiguchi; Shuji Iritani; Chikako Habuchi; Yohta Torii; Keisuke Kuroda; Kozo Kaibuchi; Norio Ozaki
Impairment of the tyrosine hydroxylase neuronal network in the orbitofrontal cortex of a genetically modified mouse model of schizophrenia.
Brain research 2011;1392():47-53.
2011: Hiroshi Qadota; Takayuki Miyauchi; John F Nahabedian; Jeffrey N Stirman; Hang Lu; Mutsuki Amano; Guy M Benian; Kozo Kaibuchi
PKN-1, a homologue of mammalian PKN, is involved in the regulation of muscle contraction and force transmission in C. elegans.
Journal of molecular biology 2011;407(2):222-31.
2011: Annika Heil; Ali Reza Nazmi; Max Koltzscher; Michaela Poeter; Judith Austermann; Nicole Assard; Jacques Baudier; Kozo Kaibuchi; Volker Gerke
S100P is a novel interaction partner and regulator of IQGAP1.
The Journal of biological chemistry 2011;286(9):7227-38.
2011: Akira Katsumi; Hitoshi Kiyoi; Akihiro Abe; Ryohei Tanizaki; Toshihiro Iwasaki; Miki Kobayashi; Tadashi Matsushita; Kozo Kaibuchi; Takeshi Senga; Tetsuhito Kojima; Takayuki Kohno; Michinari Hamaguchi; Tomoki Naoe
FLT3/ ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signalling.
European journal of haematology 2011;86(3):191-8.
2011: Masashi Ikeda; Branko Aleksic; Yoko Kinoshita; Tomo Okochi; Kunihiro Kawashima; Itaru Kushima; Yoshihito Ito; Yukako Nakamura; Taro Kishi; Takenori Okumura; Yasuhisa Fukuo; Hywel J Williams; Marian L Hamshere; Dobril Ivanov; Toshiya INADA; Michio Suzuki; Ryota Hashimoto; Hiroshi Ujike; Masatoshi Takeda; Nick Craddock; Kozo Kaibuchi; Michael J Owen; Norio Ozaki; Michael C O'Donovan; Nakao Iwata
Genome-wide association study of schizophrenia in a Japanese population.
Biological psychiatry 2011;69(5):472-8.
2011: Kenta Kobayashi; Tomoyuki Masuda; Masanori Takahashi; Jun-ichi Miyazaki; Masahiro Nakagawa; Motokazu Uchigashima; Masahiko Watanabe; Hiroyuki Yaginuma; Noriko Osumi; Kozo Kaibuchi; Kazuto Kobayashi
Rho/Rho-kinase signaling pathway controls axon patterning of a specified subset of cranial motor neurons.
The European journal of neuroscience 2011;33(4):612-21.
2011: Shinichi Nakamuta; Takashi Namba; Marina R Picciotto; Akira Sakakibara; thomas r soderling; Hiroshi Tokumitsu; Nariko Arimura; Yasuhiro Funahashi; Hiroyuki Kamiguchi; Takaki Miyata; Kozo Kaibuchi
Local application of neurotrophins specifies axons through inositol 1,4,5-trisphosphate, calcium, and Ca2+/calmodulin-dependent protein kinases.
Science signaling 2011;4(199):ra76.
2011: Honda Naoki; Shinichi Nakamuta; Kozo Kaibuchi; Shin Ishii
Flexible search for single-axon morphology during neuronal spontaneous polarization.
PloS one 2011;6(4):e19034.
2011: Akifumi Morinaka; Mayumi Yamada; Rurika Itofusa; Yosuke Funato; Yuta Yoshimura; Fumio Nakamura; Takeshi Yoshimura; Kozo Kaibuchi; Yoshio Goshima; Mikio Hoshino; Hiroyuki Kamiguchi; Hiroaki Miki
Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse.
Science signaling 2011;4(170):ra26.
2010: Shuji Iritani; Hirotaka Sekiguchi; Chikako Habuchi; Takao Hikita; Shinichiro Taya; Kozo Kaibuchi; Norio Ozaki
Immunohistochemical study of vesicle monoamine transporter 2 in the hippocampal region of genetic animal model of schizophrenia.
Synapse (New York, N.Y.) 2010;64(12):948-53.
2010: Ken-Ichiro Kubo; Kenji Tomita; Asuka Uto; Keisuke Kuroda; Saurav Seshadri; Jared Cohen; Kozo Kaibuchi; Atsushi Kamiya; Kazunori Nakajima
Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi.
Biochemical and biophysical research communications 2010;400(4):631-7.
2010: Mutsuki Amano; Masanori Nakayama; Kozo Kaibuchi
Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.
Cytoskeleton (Hoboken, N.J.) 2010;67(9):545-54.
2010: Takashi Namba; Kozo Kaibuchi
Switching DISC1 function in neurogenesis: Dixdc1 selects DISC1 binding partners.
Developmental cell 2010;19(1):7-8.
2010: Kozo Kaibuchi; Daisuke Tsuboi
[Current perspective on the pathogenesis of schizophrenia from the viewpoint of risk factors such as DISC1 (corrected)].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 2010;30(3):149-52.
2010: Atsushi Nakano; Hisakazu Kato; Takashi Watanabe; Kyung-Duk Min; Satoru Yamazaki; Yoshihiro Asano; Osamu Seguchi; Shuichiro Higo; Yasunori Shintani; Hiroshi Asanuma; Masanori Asakura; Tetsuo Minamino; Kozo Kaibuchi; Naoki Mochizuki; Masafumi Kitakaze; Seiji Takashima
AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.
Nature cell biology 2010;12(6):583-90.
2010: Norimichi Itoh; Masanori Nakayama; Takashi Nishimura; Shin Fujisue; Tomoki Nishioka; Takashi Watanabe; Kozo Kaibuchi
Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis.
Cytoskeleton (Hoboken, N.J.) 2010;67(5):297-308.
2010: Shinji Matsumoto; Katsumi Fumoto; Tetsuji Okamoto; Kozo Kaibuchi; Akira Kikuchi
Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells.
The EMBO journal 2010;29(7):1192-204.
2010: Taku Nagai; Yuko Kitahara; Anna Shiraki; Takao Hikita; Shinichiro Taya; Kozo Kaibuchi; Kiyofumi Yamada
Dysfunction of dopamine release in the prefrontal cortex of dysbindin deficient sandy mice: an in vivo microdialysis study.
Neuroscience letters 2010;470(2):134-8.
2010: Shin-ichi Terawaki; Ken Kitano; Tomoyuki Mori; Yan Zhai; Yoshiki Higuchi; Norimichi Itoh; Takashi Watanabe; Kozo Kaibuchi; Toshio Hakoshima
The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module.
The EMBO journal 2010;29(1):236-50.
2010: Mutsuki Amano; Yuta Tsumura; Kentaro Taki; Hidenori Harada; Kazutaka Mori; Tomoki Nishioka; Katsuhiro Kato; Takeshi Suzuki; Yosuke Nishioka; Akihiro Iwamatsu; Kozo Kaibuchi
A proteomic approach for comprehensively screening substrates of protein kinases such as Rho-kinase.
PloS one 2010;5(1):e8704.
2010: Mikito Takefuji; Hiroyuki Asano; Kazutaka Mori; Mutsuki Amano; Katsuhiro Kato; Takashi Watanabe; Yasuhiro Morita; Akira Katsumi; Toshiki Itoh; Tadaomi Takenawa; Akihiro Hirashiki; Hideo Izawa; Kozo Nagata; Haruo Hirayama; Fumimaro Takatsu; Tomoki Naoe; Mitsuhiro Yokota; Kozo Kaibuchi
Mutation of ARHGAP9 in patients with coronary spastic angina.
Journal of human genetics 2010;55(1):42-9.
2009: Sheng T Hou; Susan X Jiang; Amy Aylsworth; Graeme Ferguson; Jacqueline Slinn; Houwen Hu; Thomas Leung; Joachim Kappler; Kozo Kaibuchi
CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity.
Journal of neurochemistry 2009;111(3):870-81.
2009: Nariko Arimura; Atsushi Hattori; Toshihide Kimura; Shinichi Nakamuta; Yasuhiro Funahashi; Shinji Hirotsune; Kenya Furuta; Takashi Urano; Yoko Y Toyoshima; Kozo Kaibuchi
CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity.
Journal of neurochemistry 2009;111(2):380-90.
2009: Atsushi Enomoto; Naoya Asai; Takashi Namba; Yun Wang; Takuya Kato; Motoki Tanaka; Hitoshi Tatsumi; Shinichiro Taya; Daisuke Tsuboi; Keisuke Kuroda; Naoko Kaneko; Kazunobu Sawamoto; Rieko Miyamoto; Mayumi Jijiwa; Yoshiki Murakumo; Masahiro Sokabe; Tatsunori Seki; Kozo Kaibuchi; Masahide Takahashi
Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.
Neuron 2009;63(6):774-87.
2009: Takashi Watanabe; Kazuhide Sato; Kozo Kaibuchi
Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases.
Cold Spring Harbor perspectives in biology 2009;1(3):a003020.
2009: Takao Hikita; Shinichiro Taya; Yasutaka Fujino; Setsuko Taneichi-Kuroda; Kanae Ohta; Daisuke Tsuboi; Tomoyasu Shinoda; Keisuke Kuroda; Yusuke Funahashi; Junko Uraguchi-Asaki; Ryota Hashimoto; Kozo Kaibuchi
Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related protein.
Journal of neurochemistry 2009;110(5):1567-74.
2009: Ryota Hashimoto; Kazutaka Ohi; Takeya Okada; Yuka Yasuda; Hidenaga Yamamori; Hiroaki Hori; Tachio Hikita; Shinichiro Taya; Osamu Saitoh; Asako Kosuga; Masahiko Tatsumi; Kunitoshi Kamijima; Kozo Kaibuchi; Masatoshi Takeda; Hiroshi Kunugi
Association analysis between schizophrenia and the AP-3 complex genes.
Neuroscience research 2009;65(1):113-5.
2009: Takashi Watanabe; Jun Noritake; Mai Kakeno; Toshinori Matsui; Takumi Harada; Shujie Wang; Norimichi Itoh; Kazuhide Sato; Kenji Matsuzawa; Akihiro Iwamatsu; Niels Galjart; Kozo Kaibuchi
Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules.
Journal of cell science 2009;122(Pt 16):2969-79.
2009: Yohei Iguchi; Masahisa Katsuno; Jun-ichi Niwa; Shin-ichi Yamada; Jun Sone; Masahiro Waza; Hiroaki Adachi; Fumiaki Tanaka; Koh-ichi Nagata; Nariko Arimura; Takashi Watanabe; Kozo Kaibuchi; Gen Sobue
TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases.
The Journal of biological chemistry 2009;284(33):22059-66.
2009: Setsuko Taneichi-Kuroda; Shinichiro Taya; Takao Hikita; Yasutaka Fujino; Kozo Kaibuchi
Direct interaction of Dysbindin with the AP-3 complex via its mu subunit.
Neurochemistry international 2009;54(7):431-8.
2009: Nariko Arimura; Toshihide Kimura; Shinichi Nakamuta; Shinichiro Taya; Yasuhiro Funahashi; Atsushi Hattori; Akiko Shimada; Céline Ménager; Saeko Kawabata; Kayo Fujii; Akihiro Iwamatsu; Rosalind A Segal; M Fukuda; Kozo Kaibuchi
Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.
Developmental cell 2009;16(5):675-86.
2009: Katsuhiko Hata; Kozo Kaibuchi; Shinobu Inagaki; Toshihide Yamashita
Unc5B associates with LARG to mediate the action of repulsive guidance molecule.
The Journal of cell biology 2009;184(5):737-50.
2009: Kazutaka Mori; Mutsuki Amano; Mikito Takefuji; Katsuhiro Kato; Yasuhiro Morita; Tomoki Nishioka; Yoshiharu Matsuura; Toyoaki Murohara; Kozo Kaibuchi
Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP.
The Journal of biological chemistry 2009;284(8):5067-76.
2008: Toshihiro Iwasaki; Akira Katsumi; Hitoshi Kiyoi; Ryohei Tanizaki; Yuichi Ishikawa; Kazutaka Ozeki; Miki Kobayashi; Akihiro Abe; Tadashi Matsushita; Takashi Watanabe; Mutsuki Amano; Tetsuhito Kojima; Kozo Kaibuchi; Tomoki Naoe
Prognostic implication and biological roles of RhoH in acute myeloid leukaemia.
European journal of haematology 2008;81(6):454-60.
2008: Ryohei Tanizaki; Akira Katsumi; Hitoshi Kiyoi; Shinji Kunishima; Toshihiro Iwasaki; Yuichi Ishikawa; Miki Kobayashi; Akihiro Abe; Tadashi Matsushita; Takashi Watanabe; Tetsuhito Kojima; Kozo Kaibuchi; Seiji Kojima; Tomoki Naoe
Mutational analysis of SOS1 gene in acute myeloid leukemia.
International journal of hematology 2008;88(4):460-2.
2008: Masashi Ikeda; Takao Hikita; Shinichiro Taya; Junko Uraguchi-Asaki; Kazuhito Toyo-oka; Anthony Wynshaw-Boris; Hiroshi Ujike; Toshiya Inada; Keizo Takao; Tsuyoshi Miyakawa; Norio Ozaki; Kozo Kaibuchi; Nakao Iwata
Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia.
Human molecular genetics 2008;17(20):3212-22.
2008: Masahiko Sugimoto; Akihito Inoko; Takashi Shiromizu; Masanori Nakayama; Peng Zou; Shigenobu Yonemura; Yuko Hayashi; Ichiro Izawa; Mikio Sasoh; Yukitaka Uji; Kozo Kaibuchi; Tohru Kiyono; Masaki Inagaki
The keratin-binding protein Albatross regulates polarization of epithelial cells.
The Journal of cell biology 2008;183(1):19-28.
2008: Shigeko Yamashiro; Yoshihiko Yamakita; Go Totsukawa; Hidemasa Goto; Kozo Kaibuchi; Masaaki Ito; David J Hartshorne; Fumio Matsumura
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1.
Developmental cell 2008;14(5):787-97.
2008: Siriporn Patrakitkomjorn; Daiki Kobayashi; Takashi Morikawa; Masayo Morifuji Wilson; Nobuyuki Tsubota; Atsushi Irie; Tatsuya Ozawa; Masashi Aoki; Nariko Arimura; Kozo Kaibuchi; Hideyuki Saya; Norie Araki
Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2.
The Journal of biological chemistry 2008;283(14):9399-413.
2008: Nariko Arimura; Takeshi Yoshimura; Kozo Kaibuchi
[Neuronal polarity].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2008;53(4 Suppl):386-92.
2008: Masanori Nakayama; Takaaki M Goto; Masayuki Sugimoto; Takashi Nishimura; Takafumi Shinagawa; Sigeo Ohno; Mutsuki Amano; Kozo Kaibuchi
Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation.
Developmental cell 2008;14(2):205-15.
2008: Masaru Yamamoto; Servio Ramirez; Shinji Sato; Tomomi Kiyota; Ronald L Cerny; Kozo Kaibuchi; Yuri Persidsky; Tsuneya Ikezu
Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.
The American journal of pathology 2008;172(2):521-33.
2008: Takashi Watanabe; Shujie Wang; Mai Kakeno; Jiro Usukura; Kozo Kaibuchi
Ultrastructural study of Rac1 and its effectors beneath the substratum-facing membrane.
Cell structure and function 2008;33(1):101-7.
2007: Hiroshi Qadota; Kristina B Mercer; Rachel K Miller; Kozo Kaibuchi; Guy M Benian
Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle.
Molecular biology of the cell 2007;18(11):4317-26.
2007: Hiroshi Qadota; Makiko Inoue; Takao Hikita; Mathias Köppen; Jeffrey D Hardin; Mutsuki Amano; Donald G Moerman; Kozo Kaibuchi
Establishment of a tissue-specific RNAi system in C. elegans.
Gene 2007;400(1-2):166-73.
2007: Masayuki Sugimoto; Masanori Nakayama; Takaaki M Goto; Mutsuki Amano; Kimihiro Komori; Kozo Kaibuchi
Rho-kinase phosphorylates eNOS at threonine 495 in endothelial cells.
Biochemical and biophysical research communications 2007;361(2):462-7.
2007: Yoshiki Yagita; Kazuo Kitagawa; Tsutomu Sasaki; Yasukazu Terasaki; Kenichi Todo; Emi Omura-Matsuoka; Kozo Kaibuchi; Masatsugu Hori
Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.
Journal of neuroscience research 2007;85(11):2460-9.
2007: Dominique T Brandt; Sabrina Marion; Gareth Griffiths; Takashi Watanabe; Kozo Kaibuchi; Robert Grosse
Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation.
The Journal of cell biology 2007;178(2):193-200.
2007: Takashi Nishimura; Kozo Kaibuchi
Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3.
Developmental cell 2007;13(1):15-28.
2007: Masaki Mishima; Ryoko Maesaki; Miyuki Kasa; Takashi Watanabe; Masaki Fukata; Kozo Kaibuchi; Toshio Hakoshima
Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10346-51.
2007: Mikiya Otsuji; Shuji Ishihara; Carl Co; Kozo Kaibuchi; Atsushi Mochizuki; Shinya Kuroda
A mass conserved reaction-diffusion system captures properties of cell polarity.
PLoS computational biology 2007;3(6):e108.
2007: Takeshi Yoshimura; Nariko Arimura; Atsushi Hattori; Kozo Kaibuchi
[Molecular mechanisms regulating neuronal polarity via phosphorylation signaling].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2007;52(7):753-9.
2007: Mikito Takefuji; Kazutaka Mori; Yasuhiro Morita; Nariko Arimura; Takashi Nishimura; Masanori Nakayama; Mikio Hoshino; Akihiro Iwamatsu; Toyoaki Murohara; Kozo Kaibuchi; Mutsuki Amano
Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation.
Biochemical and biophysical research communications 2007;355(3):788-94.
2007: Nariko Arimura; Kozo Kaibuchi
Neuronal polarity: from extracellular signals to intracellular mechanisms.
Nature reviews. Neuroscience 2007;8(3):194-205.
2007: Shujie Wang; Takashi Watanabe; Jun Noritake; Masaki Fukata; Takeshi Yoshimura; Norimichi Itoh; Takumi Harada; Masato Nakagawa; Yoshiharu Matsuura; Nariko Arimura; Kozo Kaibuchi
IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth.
Journal of cell science 2007;120(Pt 4):567-77.
2007: Masayuki Iwakubo; Atsuya Takami; Yuji Okada; Takehisa Kawata; Yoshimichi Tagami; Motoko Sato; Terumi Sugiyama; Kayoko Fukushima; Shinichiro Taya; Mutsuki Amano; Kozo Kaibuchi; Hiroshi Iijima
Design and synthesis of rho kinase inhibitors (III).
Bioorganic & medicinal chemistry 2007;15(2):1022-33.
2007: Shinichiro Taya; Tomoyasu Shinoda; Daisuke Tsuboi; Junko Asaki; Kumiko Nagai; Takao Hikita; Setsuko Kuroda; Keisuke Kuroda; Mariko Shimizu; Shinji Hirotsune; Akihiro Iwamatsu; Kozo Kaibuchi
DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(1):15-26.
2007: Tomoyasu Shinoda; Shinichiro Taya; Daisuke Tsuboi; Takao Hikita; Reiko Matsuzawa; Setsuko Kuroda; Akihiro Iwamatsu; Kozo Kaibuchi
DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(1):4-14.
2006: Woo-Yang Kim; Fengquan Zhou; Jiang Zhou; Yukako Yokota; Yan-Min Wang; Takeshi Yoshimura; Kozo Kaibuchi; James R Woodgett; Eva Anton; William D Snider
Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth.
Neuron 2006;52(6):981-96.
2006: Kohtaro Abe; Shunsuke Tawara; Keiji Oi; Takatoshi Hizume; Toyokazu Uwatoku; Yoshihiro Fukumoto; Kozo Kaibuchi; Hiroaki Shimokawa
Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice.
Journal of cardiovascular pharmacology 2006;48(6):280-5.
2006: Zhiyong Ma; Masayuki Kanai; Kenji Kawamura; Kozo Kaibuchi; Keqiang Ye; Kenji Fukasawa
Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication.
Molecular and cellular biology 2006;26(23):9016-34.
2006: Hong Guo Jin; Hiroshi Yamashita; Yoshito Nagano; Hiromasa Fukuba; Masanori Hiji; Toshiho Ohtsuki; Tetsuya Takahashi; Tatsuo Kohriyama; Kozo Kaibuchi; Masayasu Matsumoto
Hypoxia-induced upregulation of endothelial small G protein RhoA and Rho-kinase/ROCK2 inhibits eNOS expression.
Neuroscience letters 2006;408(1):62-7.
2006: Takeshi Yoshimura; Nariko Arimura; Kozo Kaibuchi
Molecular mechanisms of axon specification and neuronal disorders.
Annals of the New York Academy of Sciences 2006;1086():116-25.
2006: Takeshi Yoshimura; Nariko Arimura; Kozo Kaibuchi
Signaling networks in neuronal polarization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(42):10626-30.
2006: Takatoshi Hizume; Keiko Morikawa; Aya Takaki; Kohtaro Abe; Kenji Sunagawa; Mutsuki Amano; Kozo Kaibuchi; Chiharu Kubo; Hiroaki Shimokawa
Sustained elevation of serum cortisol level causes sensitization of coronary vasoconstricting responses in pigs in vivo: a possible link between stress and coronary vasospasm.
Circulation research 2006;99(7):767-75.
2006: Akio Maeda; Yu-ichi Ozaki; Sudhir Sivakumaran; Tetsuro Akiyama; Hidetoshi Urakubo; Ayako Usami; Miharu Sato; Kozo Kaibuchi; Shinya Kuroda
Ca2+ -independent phospholipase A2-dependent sustained Rho-kinase activation exhibits all-or-none response.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(9):1071-83.
2006: Hiroto Yamaguchi; Yukiko Miwa; Miyuki Kasa; Ken Kitano; Mutsuki Amano; Kozo Kaibuchi; Toshio Hakoshima
Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y-27632.
Journal of biochemistry 2006;140(3):305-11.
2006: Ryuji Okamoto; Takaaki Kato; Akira Mizoguchi; Nobuaki Takahashi; Tetsuya Nakakuki; Hideo Mizutani; Naoki Isaka; Kyoko Imanaka-Yoshida; Kozo Kaibuchi; Zhaojiang Lu; Katsuhide Mabuchi; Terenc Tao; David J Hartshorne; Takeshi Nakano; Masaaki Ito
Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart.
Cellular signalling 2006;18(9):1408-16.
2006: Yuri Ito; Izumi Oinuma; Hironori Katoh; Kozo Kaibuchi; Manabu Negishi
Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapse.
EMBO reports 2006;7(7):704-9.
2006: Yuri Persidsky; David Heilman; James Haorah; Marina Zelivyanskaya; Raisa Persidsky; Gregory A Weber; Hiroaki Shimokawa; Kozo Kaibuchi; Tsuneya Ikezu
Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE).
Blood 2006;107(12):4770-80.
2006: Fumiaki Mimura; Satoru Yamagishi; Nariko Arimura; Masashi Fujitani; Takekazu Kubo; Kozo Kaibuchi; Toshihide Yamashita
Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism.
The Journal of biological chemistry 2006;281(23):15970-9.
2006: Toru Tanaka; Dai Nishimura; Ray-Chang Wu; Mutsuki Amano; Tatsuya Iso; Larry Kedes; Hiroshi Nishida; Kozo Kaibuchi; Yasuo Hamamori
Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase.
The Journal of biological chemistry 2006;281(22):15320-9.
2006: Nariko Arimura; Takeshi Yoshimura; Kozo Kaibuchi
[Neuronal polarity].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2006;51(6 Suppl):789-95.
2006: Takashi Watanabe; Jun Noritake; Shujie Wang; Takumi Harada; Kozo Kaibuchi
[Motility of fibroblast cells and its regulatory mechanisms].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2006;51(6 Suppl):715-20.
2006: Jun Noritake; Takashi Watanabe; Shujie Wang; Takumi Harada; Kozo Kaibuchi
[Roles of IQGAP1 in E-cadherin-mediated cell-cell adhesion].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2006;51(6 Suppl):648-53.
2006: Takashi Oguri; Akihito Inoko; Hiroshi Shima; Ichiro Izawa; Nariko Arimura; Tomoya Yamaguchi; Naoyuki Inagaki; Kozo Kaibuchi; Kunimi Kikuchi; Masaki Inagaki
Vimentin-Ser82 as a memory phosphorylation site in astrocytes.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(5):531-40.
2006: Hiroto Yamaguchi; Miyuki Kasa; Mutsuki Amano; Kozo Kaibuchi; Toshio Hakoshima
Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil.
Structure (London, England : 1993) 2006;14(3):589-600.
2006: Takashi Nishimura; Tomoya Yamaguchi; Akinori Tokunaga; Akitoshi Hara; Tomonari Hamaguchi; Katsuhiro Kato; Akihiro Iwamatsu; Hideyuki Okano; Kozo Kaibuchi
Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2.
Molecular biology of the cell 2006;17(3):1273-85.
2006: Candice G T Tahimic; Nozomi Tomimatsu; Ryuichi Nishigaki; Akiko Fukuhara; Tosifusa Toda; Kozo Kaibuchi; Goshi Shiota; Mitsuo Oshimura; Akihiro Kurimasa
Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells.
Biochemical and biophysical research communications 2006;340(4):1244-50.
2006: Takeshi Yoshimura; Nariko Arimura; Yoji Kawano; Saeko Kawabata; Shujie Wang; Kozo Kaibuchi
Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway.
Biochemical and biophysical research communications 2006;340(1):62-8.
2005: Nariko Arimura; Kozo Kaibuchi
Key regulators in neuronal polarity.
Neuron 2005;48(6):881-4.
2005: Daisuke Tsuboi; Takao Hikita; Hiroshi Qadota; Mutsuki Amano; Kozo Kaibuchi
Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans.
Journal of neurochemistry 2005;95(6):1629-41.
2005: Nariko Arimura; Céline Ménager; Yoji Kawano; Takeshi Yoshimura; Saeko Kawabata; Atsushi Hattori; Yuko Fukata; Mutsuki Amano; Yoshio Goshima; Masaki Inagaki; Nobuhiro Morone; Jiro Usukura; Kozo Kaibuchi
Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones.
Molecular and cellular biology 2005;25(22):9973-84.
2005: Yoji Kawano; Takeshi Yoshimura; Daisuke Tsuboi; Saeko Kawabata; Takako Kaneko-Kawano; Hiromichi Shirataki; Tadaomi Takenawa; Kozo Kaibuchi
CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.
Molecular and cellular biology 2005;25(22):9920-35.
2005: Takako Kaneko; Akio Maeda; Mikito Takefuji; Hiroki Aoyama; Masanori Nakayama; Saeko Kawabata; Yoji Kawano; Akihiro Iwamatsu; Mutsuki Amano; Kozo Kaibuchi
Rho mediates endocytosis of epidermal growth factor receptor through phosphorylation of endophilin A1 by Rho-kinase.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(10):973-87.
2005: Takao Hikita; Hiroshi Qadota; Daisuke Tsuboi; Shinichiro Taya; Donald G Moerman; Kozo Kaibuchi
Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure.
Biochemical and biophysical research communications 2005;335(1):139-45.
2005: Atsushi Enomoto; Hideki Murakami; Naoya Asai; Nobuhiro Morone; Takashi Watanabe; Kumi Kawai; Yoshiki Murakumo; Jiro Usukura; Kozo Kaibuchi; Masahide Takahashi
Akt/PKB regulates actin organization and cell motility via Girdin/APE.
Developmental cell 2005;9(3):389-402.
2005: Takeshi Yoshimura; Yoji Kawano; Nariko Arimura; Saeko Kawabata; Kozo Kaibuchi
[Molecular mechanisms of neuronal polarity].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 2005;25(4):169-74.
2005: Noboru Furukawa; Pat Ongusaha; Wan Jin Jahng; Kazushi Araki; Cheol Soo Choi; Hyo-Jeong Kim; Yong Hee Lee; Kozo Kaibuchi; Barbara B Kahn; Hiroaki Masuzaki; Jason K Kim; Sam W Lee; Young-Bum Kim
Role of Rho-kinase in regulation of insulin action and glucose homeostasis.
Cell metabolism 2005;2(2):119-29.
2005: Satoshi Tamaru; Tetsu Fukuta; Kozo Kaibuchi; Yoichiro Matsuoka; Hiroshi Shiku; Masakatsu Nishikawa
Rho-kinase induces association of adducin with the cytoskeleton in platelet activation.
Biochemical and biophysical research communications 2005;332(2):347-51.
2005: Jun Xu; S Taya; Kozo Kaibuchi; Arthur P Arnold
Sexually dimorphic expression of Usp9x is related to sex chromosome complement in adult mouse brain.
The European journal of neuroscience 2005;21(11):3017-22.
2005: Toshihide Kimura; Hiroyasu Watanabe; Akihiro Iwamatsu; Kozo Kaibuchi
Tubulin and CRMP-2 complex is transported via Kinesin-1.
Journal of neurochemistry 2005;93(6):1371-82.
2005: Jun Noritake; Takashi Watanabe; Kazumasa Sato; Shujie Wang; Kozo Kaibuchi
IQGAP1: a key regulator of adhesion and migration.
Journal of cell science 2005;118(Pt 10):2085-92.
2005: Akira Katsumi; Tomoki Naoe; Tadashi Matsushita; Kozo Kaibuchi; Martin A Schwartz
Integrin activation and matrix binding mediate cellular responses to mechanical stretch.
The Journal of biological chemistry 2005;280(17):16546-9.
2005: Jun Xu; Shinichiro Taya; Kozo Kaibuchi; Arthur P Arnold
Spatially and temporally specific expression in mouse hippocampus of Usp9x, a ubiquitin-specific protease involved in synaptic development.
Journal of neuroscience research 2005;80(1):47-55.
2005: Takashi Nishimura; Tomoya Yamaguchi; Katsuhiro Kato; Masato Yoshizawa; Yo-ichi Nabeshima; Shigeo Ohno; Mikio Hoshino; Kozo Kaibuchi
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
Nature cell biology 2005;7(3):270-7.
2005: Takashi Watanabe; Jun Noritake; Kozo Kaibuchi
Regulation of microtubules in cell migration.
Trends in cell biology 2005;15(2):76-83.
2005: Masanori Nakayama; Mutsuki Amano; Akira Katsumi; Takako Kaneko; Saeko Kawabata; Mikito Takefuji; Kozo Kaibuchi
Rho-kinase and myosin II activities are required for cell type and environment specific migration.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(2):107-17.
2005: Kohtaro Abe; Keiko Morikawa; Takatoshi Hizume; Toyokazu Uwatoku; Keiji Oi; Minoru Seto; Ichiro Ikegaki; Toshio Asano; Kozo Kaibuchi; Hiroaki Shimokawa
Prostacyclin does not inhibit rho-kinase: an implication for the treatment of pulmonary hypertension.
Journal of cardiovascular pharmacology 2005;45(2):120-4.
2005: Takeshi Yoshimura; Yoji Kawano; Nariko Arimura; Saeko Kawabata; Akira Kikuchi; Kozo Kaibuchi
GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.
Cell 2005;120(1):137-49.
2005: Takashi Watanabe; Jun Noritake; Kozo Kaibuchi
Roles of IQGAP1 in cell polarization and migration.
Novartis Foundation symposium 2005;269():92-101; discussion 101-5, 223-30.
2004: Anna A Birukova; Konstantin G Birukov; Ksenya Smurova; Djanybek Adyshev; Kozo Kaibuchi; Irina B Alieva; Joe G. N. Garcia; Alexander Dmitriyevich Verin
Novel role of microtubules in thrombin-induced endothelial barrier dysfunction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(15):1879-90.
2004: Takashi Watanabe; Shujie Wang; Jun Noritake; Kazumasa Sato; Masaki Fukata; Mikito Takefuji; Masato Nakagawa; Nanae Izumi; Tetsu Akiyama; Kozo Kaibuchi
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration.
Developmental cell 2004;7(6):871-83.
2004: Takeshi Sato; Yoshiakira Kanai; Takashi Noma; Masami Kanai-Azuma; Shinichiro Taya; Toshiyasu Matsui; Maki Ishii; Hayato Kawakami; Masamichi Kurohmaru; Kozo Kaibuchi; Stephen A Wood; Yoshihiro Hayashi
A close correlation in the expression patterns of Af-6 and Usp9x in Sertoli and granulosa cells of mouse testis and ovary.
Reproduction (Cambridge, England) 2004;128(5):583-94.
2004: Koji Ito; Yoshitaka Hirooka; Yoji Sagara; Yoshikuni Kimura; Kozo Kaibuchi; Hiroaki Shimokawa; Akira Takeshita; Kenji Sunagawa
Inhibition of Rho-kinase in the brainstem augments baroreflex control of heart rate in rats.
Hypertension 2004;44(4):478-83.
2004: Anna A Birukova; Ksenya Smurova; Konstantin G Birukov; Peter Usatyuk; Feng Liu; Kozo Kaibuchi; Anila Ricks-Cord; Viswanathan Natarajan; Irina B Alieva; Joe G. N. Garcia; Alexander Dmitriyevich Verin
Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms.
Journal of cellular physiology 2004;201(1):55-70.
2004: Yukiko Nakaya; Shinya Kuroda; Yuji T Katagiri; Kozo Kaibuchi; Yoshiko Takahashi
Mesenchymal-epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1.
Developmental cell 2004;7(3):425-38.
2004: Junko Hiroki; Hiroaki Shimokawa; Midoriko Higashi; Keiko Morikawa; Tadashi Kandabashi; Natsumi Kawamura; Toru Kubota; Toshihiro Ichiki; Mutsuki Amano; Kozo Kaibuchi; Akira Takeshita
Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells.
Journal of molecular and cellular cardiology 2004;37(2):537-46.
2004: Xiang-dong D Ren; Ruixue Wang; Qinyuan Li; Lobna A F Kahek; Kozo Kaibuchi; Richard A F Clark
Disruption of Rho signal transduction upon cell detachment.
Journal of cell science 2004;117(Pt 16):3511-8.
2004: Saeko Kawabata; Jiro Usukura; Nobuhiro Morone; Masaaki Ito; Akihiro Iwamatsu; Kozo Kaibuchi; Mutsuki Amano
Interaction of Rho-kinase with myosin II at stress fibres.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(7):653-60.
2004: Tsuyoshi Hattori; Hiroaki Shimokawa; Midoriko Higashi; Junko Hiroki; Yasushi Mukai; Hiroyuki Tsutsui; Kozo Kaibuchi; Akira Takeshita
Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.
Circulation 2004;109(18):2234-9.
2004: Atsuya Takami; Masayuki Iwakubo; Yuji Okada; Takehisa Kawata; Hideharu Odai; Nobuaki Takahashi; Kazutoshi Shindo; Kaname Kimura; Yoshimichi Tagami; Mika Miyake; Kayoko Fukushima; Masaki Inagaki; Mutsuki Amano; Kozo Kaibuchi; Hiroshi Iijima
Design and synthesis of Rho kinase inhibitors (I).
Bioorganic & medicinal chemistry 2004;12(9):2115-37.
2004: Kenta Kobayashi; Masanori Takahashi; Natsuki Matsushita; Jun-ichi Miyazaki; Masato Koike; Hiroyuki Yaginuma; Noriko Osumi; Kozo Kaibuchi; Kazuto Kobayashi
Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(14):3480-8.
2004: Nobuyuki Moriki; Masaaki Ito; Tetsuya Seko; Yasuko Kureishi; Ryuji Okamoto; Tetsuya Nakakuki; Mariko Kongo; Naoki Isaka; Kozo Kaibuchi; Takeshi Nakano
RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2004;27(4):263-70.
2004: Takashi Nishimura; Katsuhiro Kato; Tomoya Yamaguchi; Yuko Fukata; Shigeo Ohno; Kozo Kaibuchi
Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity.
Nature cell biology 2004;6(4):328-34.
2004: Céline Ménager; Nariko Arimura; Yuko Fukata; Kozo Kaibuchi
PIP3 is involved in neuronal polarization and axon formation.
Journal of neurochemistry 2004;89(1):109-18.
2004: Masanori Nakayama; Mutsuki Amano; Saeko Kawabata; Kozo Kaibuchi; Mikito Takefuji
[Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 3():202-6.
2004: Jun Noritake; Masaki Fukata; Kazumasa Sato; Masato Nakagawa; Takashi Watanabe; Nanae Izumi; Shujie Wang; Yuko Fukata; Kozo Kaibuchi
Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact.
Molecular biology of the cell 2004;15(3):1065-76.
2004: Kohtaro Abe; Hiroaki Shimokawa; Keiko Morikawa; Toyokazu Uwatoku; Keiji Oi; Yasuharu Matsumoto; Tsuyoshi Hattori; Yutaka Nakashima; Kozo Kaibuchi; Katsuo Sueishi; Akira Takeshit
Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.
Circulation research 2004;94(3):385-93.
2004: Koji Ito; Yoshitaka Hirooka; Takuya Kishi; Yoshikuni Kimura; Kozo Kaibuchi; Hiroaki Shimokawa; Akira Takeshita
Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition.
Hypertension 2004;43(2):156-62.
2004: Tsuyoshi Hattori; Hiroaki Shimokawa; Midoriko Higashi; Junko Hiroki; Yasushi Mukai; Kozo Kaibuchi; Akira Takeshita
Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice.
Circulation research 2004;94(1):46-52.
2004: Anna A Birukova; Ksenya Smurova; Konstantin G Birukov; Kozo Kaibuchi; Joe G. N. Garcia; Alexander Dmitriyevich Verin
Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction.
Microvascular research 2004;67(1):64-77.
2004: Nariko Arimura; Celine Menager; Yuko Fukata; Kozo Kaibuchi
Role of CRMP-2 in neuronal polarity.
Journal of neurobiology 2004;58(1):34-47.
2003: Brian Becknell; Tiansheng Shen; Eman Maghraby; Shinichiro Taya; Kozo Kaibuchi; Michael A Caligiuri; Guido Marcucci
Characterization of leukemia-associated Rho guanine nucleotide exchange factor (LARG) expression during murine development.
Cell and tissue research 2003;314(3):361-6.
2003: Toshiyuki Shimizu; Kentaro Ihara; Ryoko Maesaki; Mutsuki Amano; Kozo Kaibuchi; Toshio Hakoshima
Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase.
The Journal of biological chemistry 2003;278(46):46046-51.
2003: Mutsuki Amano; Takako Kaneko; Akio Maeda; Masanori Nakayama; Masaaki Ito; Takashi Yamauchi; Hideyuki Goto; Yuko Fukata; Noriko Oshiro; Azusa Shinohara; Akihiro Iwamatsu; Kozo Kaibuchi
Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase.
Journal of neurochemistry 2003;87(3):780-90.
2003: Masaki Fukata; Masato Nakagawa; Kozo Kaibuchi
Roles of Rho-family GTPases in cell polarisation and directional migration.
Current opinion in cell biology 2003;15(5):590-7.
2003: Takashi Nishimura; Yuko Fukata; Katsuhiro Kato; Tomoya Yamaguchi; Yoshiharu Matsuura; Hiroyuki Kamiguchi; Kozo Kaibuchi
CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth.
Nature cell biology 2003;5(9):819-26.
2003: Yasuhiro Suzuki; Saya Nakagomi; Kazuhiko Namikawa; Sumiko Kiryu-Seo; Naoyuki Inagaki; Kozo Kaibuchi; Hitoshi Aizawa; Kenjiro Kikuchi; Hiroshi Kiyama
Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured motor neurons of rat.
Journal of neurochemistry 2003;86(4):1042-50.
2003: Harald Genth; Ralf Gerhard; Akio Maeda; Mutsuki Amano; Kozo Kaibuchi; Klaus Aktories; Ingo Just
Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 exoenzyme in the Rho-guanine nucleotide dissociation inhibitor-1 complex.
The Journal of biological chemistry 2003;278(31):28523-7.
2003: Pierre-Louis Tharaux; Richard C Bukoski; Paulo N Rocha; Steven D Crowley; Phillip Ruiz; Chandra Nataraj; David N Howell; Kozo Kaibuchi; Robert F Spurney; Thomas M Coffman
Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):96-105.
2003: Koji Ito; Yoshitaka Hirooka; Koji Sakai; Takuya Kishi; Kozo Kaibuchi; Hiroaki Shimokawa; Akira Takeshita
Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: possible involvement in neural mechanisms of hypertension.
Circulation research 2003;92(12):1337-43.
2003: Li Su; Masakazu Hattori; Masaki Moriyama; Norihito Murata; Masashi Harazaki; Kozo Kaibuchi; Nagahiro Minato
AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1.
The Journal of biological chemistry 2003;278(17):15232-8.
2003: Céline Ménager; Kozo Kaibuchi
[Rho proteins: their function in neurons].
Médecine sciences : M/S 2003;19(3):358-63.
2002: Xiu-Fen Ming; Hema Viswambharan; Christine Barandier; Jean Ruffieux; Kozo Kaibuchi; Sandro Rusconi; Zhihong Yang
Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells.
Molecular and cellular biology 2002;22(24):8467-77.
2002: Akio Maeda; Mutsuki Amano; Yuko Fukata; Kozo Kaibuchi
Translocation of Na(+),K(+)-ATPase is induced by Rho small GTPase in renal epithelial cells.
Biochemical and biophysical research communications 2002;297(5):1231-7.
2002: Yoji Kawano; Takeshi Yoshimura; Kozo Kaibuchi
[Involvement of small GTPase Rho in cardiovascular diseases].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2002;120(3):149-58.
2002: Yuko Fukata; Toshihide Kimura; Kozo Kaibuchi
Axon specification in hippocampal neurons.
Neuroscience research 2002;43(4):305-15.
2002: Yuko Fukata; Tomohiko J Itoh; Toshihide Kimura; Céline Ménager; Takashi Nishimura; Takashi Shiromizu; Hiroyasu Watanabe; Naoyuki Inagaki; Akihiro Iwamatsu; Hirokazu Hotani; Kozo Kaibuchi
CRMP-2 binds to tubulin heterodimers to promote microtubule assembly.
Nature cell biology 2002;4(8):583-91.
2002: Masaki Fukata; Takashi Watanabe; Jun Noritake; Masato Nakagawa; Masaki Yamaga; Shinya Kuroda; Yoshiharu Matsuura; Akihiro Iwamatsu; Franck Perez; Kozo Kaibuchi
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170.
Cell 2002;109(7):873-85.
2002: Yoji Kawano; Takeshi Yoshimura; Kozo Kaibuchi
Smooth muscle contraction by small GTPase Rho.
Nagoya journal of medical science 2002;65(1-2):1-8.
2002: Daisuke Tsuboi; Hiroshi Qadota; Katsuhisa Kasuya; Mutsuki Amano; Kozo Kaibuchi
Isolation of the interacting molecules with GEX-3 by a novel functional screening.
Biochemical and biophysical research communications 2002;292(3):697-701.
2002: Martha C Soto; Hiroshi Qadota; Katsuhisa Kasuya; Makiko Inoue; Daisuke Tsuboi; Craig C Mello; Kozo Kaibuchi
The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans.
Genes & development 2002;16(5):620-32.
2002: Chu Kataoka; Kensuke Egashira; Shujiro Inoue; Masao Takemoto; Weihua Ni; Masamichi Koyanagi; Shiro Kitamoto; Makoto Usui; Kozo Kaibuchi; Hiroaki Shimokawa; Akira Takeshita
Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats.
Hypertension 2002;39(2):245-50.
2002: Tadashi Kandabashi; Hiroaki Shimokawa; Yasushi Mukai; Tetsuya Matoba; Ikuko Kunihiro; Keiko Morikawa; Masaaki Ito; Shosuke Takahashi; Kozo Kaibuchi; Akira Takeshita
Involvement of rho-kinase in agonists-induced contractions of arteriosclerotic human arteries.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(2):243-8.
2002: Masaki Fukata; Masato Nakagawa; Shinya Kuroda; Kozo Kaibuchi
Effects of Rho family GTPases on cell-cell adhesion.
Methods in molecular biology (Clifton, N.J.) 2002;189():121-8.
2001: Kunio Morishige; Hiroaki Shimokawa; Yasuhiro Eto; M Hoshijima; Kozo Kaibuchi; Akira Takeshita
In vivo gene transfer of dominant-negative rho-kinase induces regression of coronary arteriosclerosis in pigs.
Annals of the New York Academy of Sciences 2001;947():407-11.
2001: Masaki Fukata; Kozo Kaibuchi
Rho-family GTPases in cadherin-mediated cell-cell adhesion.
Nature reviews. Molecular cell biology 2001;2(12):887-97.
2001: Marie Pantaleon; Masami Kanai-Azuma; John S Mattick; Kozo Kaibuchi; Peter L Kaye; Stephen A Wood
FAM deubiquitylating enzyme is essential for preimplantation mouse embryo development.
Mechanisms of development 2001;109(2):151-60.
2001: M Kato; N Seki; S Sugano; Katsuyuki Hashimoto; Y Masuho; M Muramatsu; Kozo Kaibuchi; M Nakafuku
Identification of sonic hedgehog-responsive genes using cDNA microarray.
Biochemical and biophysical research communications 2001;289(2):472-8.
2001: Shinichiro Taya; Naoyuki Inagaki; H Sengiku; H Makino; Akihiro Iwamatsu; I Urakawa; K Nagao; S Kataoka; Kozo Kaibuchi
Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF.
The Journal of cell biology 2001;155(5):809-20.
2001: Keizo Ohnaka; Seiko Shimoda; Hajime Nawata; Hiroaki Shimokawa; Kozo Kaibuchi; Y Iwamoto; Ryoichi Takayanagi
Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts.
Biochemical and biophysical research communications 2001;287(2):337-42.
2001: Naoyuki Inagaki; K Chihara; Nariko Arimura; Céline Ménager; Y Kawano; N Matsuo; Takashi Nishimura; Mutsuki Amano; Kozo Kaibuchi
CRMP-2 induces axons in cultured hippocampal neurons.
Nature neuroscience 2001;4(8):781-2.
2001: Yuko Funakoshi; Toshihiro Ichiki; Hiroaki Shimokawa; Kensuke Egashira; Kiyoshi Takeda; Kozo Kaibuchi; M Takeya; T Yoshimura; Akira Takeshita
Rho-kinase mediates angiotensin II-induced monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells.
Hypertension 2001;38(1):100-4.
2001: Hiroaki Shimokawa; Kunio Morishige; Kenji Miyata; Tadashi Kandabashi; Yasuhiro Eto; Ichiro Ikegaki; Toshio Asano; Kozo Kaibuchi; Akira Takeshita
Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo.
Cardiovascular research 2001;51(1):169-77.
2001: Masato Nakagawa; Masaki Fukata; Masaki Yamaga; N Itoh; Kozo Kaibuchi
Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites.
Journal of cell science 2001;114(Pt 10):1829-38.
2001: Kunio Morishige; Hiroaki Shimokawa; Yasuhiro Eto; Tadashi Kandabashi; Kenji Miyata; Yasuharu Matsumoto; M Hoshijima; Kozo Kaibuchi; Akira Takeshita
Adenovirus-mediated transfer of dominant-negative rho-kinase induces a regression of coronary arteriosclerosis in pigs in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(4):548-54.
2001: Yasushi Mukai; Hiroaki Shimokawa; Tetsuya Matoba; Tadashi Kandabashi; S Satoh; Junko Hiroki; Kozo Kaibuchi; Akira Takeshita
Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(6):1062-4.
2001: Masaki Fukata; Masato Nakagawa; N Itoh; A Kawajiri; Masaki Yamaga; Shinya Kuroda; Kozo Kaibuchi
Involvement of IQGAP1, an effector of Rac1 and Cdc42 GTPases, in cell-cell dissociation during cell scattering.
Molecular and cellular biology 2001;21(6):2165-83.
2001: S Araki; Masaaki Ito; Yasuko Kureishi; J Feng; H Machida; Naoki Isaka; M Amano; Kozo Kaibuchi; David J Hartshorne; Takeshi Nakano
Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase.
Pflügers Archiv : European journal of physiology 2001;441(5):596-603.
2001: Yuko Fukata; Mutsuki Amano; Kozo Kaibuchi
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells.
Trends in pharmacological sciences 2001;22(1):32-9.
2000: Mutsuki Amano; Yuko Fukata; Kozo Kaibuchi
Regulation and functions of Rho-associated kinase.
Experimental cell research 2000;261(1):44-51.
2000: T Izawa; Yuko Fukata; T Kimura; Akihiro Iwamatsu; K Dohi; Kozo Kaibuchi
Elongation factor-1 alpha is a novel substrate of rho-associated kinase.
Biochemical and biophysical research communications 2000;278(1):72-8.
2000: Kenji Miyata; Hiroaki Shimokawa; Tadashi Kandabashi; T Higo; Kunio Morishige; Yasuhiro Eto; Kensuke Egashira; Kozo Kaibuchi; Akira Takeshita
Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(11):2351-8.
2000: T Hamaguchi; Masaaki Ito; J Feng; Tetsuya Seko; M Koyama; H Machida; K Takase; M Amano; Kozo Kaibuchi; David J Hartshorne; Takeshi Nakano
Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N.
Biochemical and biophysical research communications 2000;274(3):825-30.
2000: Nariko Arimura; Naoyuki Inagaki; K Chihara; Céline Ménager; N Nakamura; Mutsuki Amano; Akihiro Iwamatsu; Yoshio Goshima; Kozo Kaibuchi
Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse.
The Journal of biological chemistry 2000;275(31):23973-80.
2000: Kentaro Ihara; Toshiyuki Shimizu; Ryoko Maesaki; Kengo Okada; Mutsuki Amano; Kozo Kaibuchi; Toshio Hakoshima
Crystallization and preliminary crystallographic analysis of the Rho-binding domain of bovine Rho-kinase.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 8):1042-4.
2000: A Kawajiri; N Itoh; Masaki Fukata; Masato Nakagawa; Masaki Yamaga; Akihiro Iwamatsu; Kozo Kaibuchi
Identification of a novel beta-catenin-interacting protein.
Biochemical and biophysical research communications 2000;273(2):712-7.
2000: N Nakamura; Noriko Oshiro; Yuko Fukata; Mutsuki Amano; Masaki Fukata; Shinya Kuroda; Y Matsuura; T Leung; L Lim; Kozo Kaibuchi
Phosphorylation of ERM proteins at filopodia induced by Cdc42.
Genes to cells : devoted to molecular & cellular mechanisms 2000;5(7):571-81.
2000: Ryota Hashimoto; Yusuke Nakamura; S Komai; Y Kashiwagi; K Tamura; T Goto; Saburo Aimoto; Kozo Kaibuchi; Sadao Shiosaka; Masatoshi Takeda
Site-specific phosphorylation of neurofilament-L is mediated by calcium/calmodulin-dependent protein kinase II in the apical dendrites during long-term potentiation.
Journal of neurochemistry 2000;75(1):373-82.
2000: T Kaneko; Mutsuki Amano; A Maeda; H Goto; K Takahashi; M Ito; Kozo Kaibuchi
Identification of calponin as a novel substrate of Rho-kinase.
Biochemical and biophysical research communications 2000;273(1):110-6.
2000: Toshiyuki Shimizu; Kentaro Ihara; Ryoko Maesaki; S Kuroda; Kozo Kaibuchi; Toshio Hakoshima
An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism.
The Journal of biological chemistry 2000;275(24):18311-7.
2000: Yasuhiro Eto; Hiroaki Shimokawa; Junko Hiroki; Kunio Morishige; Tadashi Kandabashi; Yasuharu Matsumoto; Mutsuki Amano; M Hoshijima; Kozo Kaibuchi; Akira Takeshita
Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs.
American journal of physiology. Heart and circulatory physiology 2000;278(6):H1744-50.
2000: Tadashi Kandabashi; Hiroaki Shimokawa; Kenji Miyata; Ikuko Kunihiro; Y Kawano; Y Fukata; T Higo; Kensuke Egashira; Shosuke Takahashi; Kozo Kaibuchi; Akira Takeshita
Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta.
Circulation 2000;101(11):1319-23.
2000: Masami Kanai-Azuma; John S Mattick; Kozo Kaibuchi; Stephen A Wood
Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development.
Mechanisms of development 2000;91(1-2):383-6.
2000: Mutsuki Amano; Yuko Fukata; H Shimokawa; Kozo Kaibuchi
Purification and in vitro activity of Rho-associated kinase.
Methods in enzymology 2000;325():149-55.
1999: Yuko Fukata; Noriko Oshiro; Kozo Kaibuchi
Activation of moesin and adducin by Rho-kinase downstream of Rho.
Biophysical chemistry 1999;82(2-3):139-47.
1999: Hiroyasu Inada; H Togashi; Y Nakamura; Kozo Kaibuchi; Koh-ichi Nagata; Masaki Inagaki
Balance between activities of Rho kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filaments.
The Journal of biological chemistry 1999;274(49):34932-9.
1999: Shinichiro Taya; T Yamamoto; Masami Kanai-Azuma; Stephen A Wood; Kozo Kaibuchi
The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin.
Genes to cells : devoted to molecular & cellular mechanisms 1999;4(12):757-67.
1999: Masaki Fukata; Masato Nakagawa; S Kuroda; Kozo Kaibuchi
Cell adhesion and Rho small GTPases.
Journal of cell science 1999;112 ( Pt 24)():4491-500.
1999: Y Kawano; Yuko Fukata; Noriko Oshiro; Mutsuki Amano; T Nakamura; Masaaki Ito; F Matsumura; M Inagaki; Kozo Kaibuchi
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo.
The Journal of cell biology 1999;147(5):1023-38.
1999: Mutsuki Amano; K Chihara; N Nakamura; T Kaneko; Y Matsuura; Kozo Kaibuchi
The COOH terminus of Rho-kinase negatively regulates rho-kinase activity.
The Journal of biological chemistry 1999;274(45):32418-24.
1999: Ryoko Maesaki; Kentaro Ihara; Toshiyuki Shimizu; S Kuroda; Kozo Kaibuchi; Toshio Hakoshima
The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.
Molecular cell 1999;4(5):793-803.
1999: T Yamamoto; Shinichiro Taya; Kozo Kaibuchi
Ras-induced transformation and signaling pathway.
Journal of biochemistry 1999;126(5):799-803.
1999: T Mizuno; Mutsuki Amano; Kozo Kaibuchi; Y Nishida
Identification and characterization of Drosophila homolog of Rho-kinase.
Gene 1999;238(2):437-44.
1999: Ryota Hashimoto; Yusuke Nakamura; H Kosako; M Amano; Kozo Kaibuchi; Maiko Inagaki; Masatoshi Takeda
Distribution of Rho-kinase in the bovine brain.
Biochemical and biophysical research communications 1999;263(2):575-9.
1999: Masaki Fukata; Shinya Kuroda; Masato Nakagawa; A Kawajiri; N Itoh; I Shoji; Y Matsuura; S Yonehara; H Fujisawa; A Kikuchi; Kozo Kaibuchi
Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin.
The Journal of biological chemistry 1999;274(37):26044-50.
1999: Hiroaki Shimokawa; Minoru Seto; N Katsumata; Mutsuki Amano; Toshiyuki Kozai; Tohru Yamawaki; Koichi Kuwata; Tadashi Kandabashi; Kensuke Egashira; Ichiro Ikegaki; Toshio Asano; Kozo Kaibuchi; Akira Takeshita
Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm.
Cardiovascular research 1999;43(4):1029-39.
1999: Shinya Kuroda; Masaki Fukata; Masato Nakagawa; Kozo Kaibuchi
Cdc42, Rac1, and their effector IQGAP1 as molecular switches for cadherin-mediated cell-cell adhesion.
Biochemical and biophysical research communications 1999;262(1):1-6.
1999: Ryoko Maesaki; Toshiyuki Shimizu; Kentaro Ihara; S Kuroda; Kozo Kaibuchi; Toshio Hakoshima
Biochemical and crystallographic characterization of a Rho effector domain of the protein serine/threonine kinase N in a complex with RhoA.
Journal of structural biology 1999;126(2):166-70.
1999: T Yamamoto; N Harada; Y Kawano; Shinichiro Taya; Kozo Kaibuchi
In vivo interaction of AF-6 with activated Ras and ZO-1.
Biochemical and biophysical research communications 1999;259(1):103-7.
1999: Yuko Fukata; Noriko Oshiro; N Kinoshita; Y Kawano; Yasuji Matsuoka; V Bennett; Y Matsuura; Kozo Kaibuchi
Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility.
The Journal of cell biology 1999;145(2):347-61.
1999: K Tsubakimoto; K Matsumoto; H Abe; J Ishii; M Amano; Kozo Kaibuchi; Takeshi Endo
Small GTPase RhoD suppresses cell migration and cytokinesis.
Oncogene 1999;18(15):2431-40.
1999: J Feng; Masaaki Ito; Yasuko Kureishi; K Ichikawa; M Amano; Naoki Isaka; K Okawa; A Iwamatsu; Kozo Kaibuchi; David J Hartshorne; Takeshi Nakano
Rho-associated kinase of chicken gizzard smooth muscle.
The Journal of biological chemistry 1999;274(6):3744-52.
1999: Kozo Kaibuchi
Regulation of cytoskeleton and cell adhesion by Rho targets.
Progress in molecular and subcellular biology 1999;22():23-38.
1998: Noriko Oshiro; Yuko Fukata; Kozo Kaibuchi
Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures.
The Journal of biological chemistry 1998;273(52):34663-6.
1998: I Izawa; Mutsuki Amano; K Chihara; T Yamamoto; Kozo Kaibuchi
Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation.
Oncogene 1998;17(22):2863-71.
1998: Shinichiro Taya; T Yamamoto; K Kano; Y Kawano; Akihiro Iwamatsu; T Tsuchiya; K Tanaka; Masami Kanai-Azuma; Stephen A Wood; John S Mattick; Kozo Kaibuchi
The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme.
The Journal of cell biology 1998;142(4):1053-62.
1998: Shinya Kuroda; Masaki Fukata; Masato Nakagawa; K Fujii; T Nakamura; T Ookubo; I Izawa; T Nagase; N Nomura; H Tani; I Shoji; Y Matsuura; S Yonehara; Kozo Kaibuchi
Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion.
Science (New York, N.Y.) 1998;281(5378):832-5.
1998: Yuko Fukata; K Kimura; Noriko Oshiro; H Saya; Y Matsuura; Kozo Kaibuchi
Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase.
The Journal of cell biology 1998;141(2):409-18.
1998: Ryota Hashimoto; Yusuke Nakamura; H Goto; Youichiro Wada; Saburo Sakoda; Kozo Kaibuchi; Maiko Inagaki; Masatoshi Takeda
Domain- and site-specific phosphorylation of bovine NF-L by Rho-associated kinase.
Biochemical and biophysical research communications 1998;245(2):407-11.
1998: M Fujioka; N Takahashi; H Odai; S Araki; K Ichikawa; J Feng; M Nakamura; Kozo Kaibuchi; David J Hartshorne; Takeshi Nakano; Masaaki Ito
A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping.
Genomics 1998;49(1):59-68.
1998: Yoshihiro Kita; K D Kimura; Michimoto Kobayashi; Sayoko Ihara; Kozo Kaibuchi; S Kuroda; M Ui; H Iba; Hiroaki Konishi; U Kikkawa; Satoshi Nagata; Yasuhisa Fukui
Microinjection of activated phosphatidylinositol-3 kinase induces process outgrowth in rat PC12 cells through the Rac-JNK signal transduction pathway.
Journal of cell science 1998;111 ( Pt 7)():907-15.
1998: Kazushi Kimura; Yuko Fukata; Yasuji Matsuoka; V Bennett; Y Matsuura; Katsuya Okawa; A Iwamatsu; Kozo Kaibuchi
Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase.
The Journal of biological chemistry 1998;273(10):5542-8.
1998: Mutsuki Amano; K Chihara; N Nakamura; Yuko Fukata; T Yano; M Shibata; M Ikebe; Kozo Kaibuchi
Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase.
Genes to cells : devoted to molecular & cellular mechanisms 1998;3(3):177-88.
1998: Takeshi Matsui; M Maeda; Y Doi; Shigenobu Yonemura; M Amano; Kozo Kaibuchi; Shoichiro Tsukita; S Tsukita
Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association.
The Journal of cell biology 1998;140(3):647-57.
1998: K Kobayashi; Shinya Kuroda; Masaki Fukata; T Nakamura; T Nagase; N Nomura; Y Matsuura; N Yoshida-Kubomura; Akihiro Iwamatsu; Kozo Kaibuchi
p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase.
The Journal of biological chemistry 1998;273(1):291-5.
1997: Masaki Fukata; Shinya Kuroda; K Fujii; T Nakamura; I Shoji; Y Matsuura; K Okawa; Akihiro Iwamatsu; A Kikuchi; Kozo Kaibuchi
Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42.
The Journal of biological chemistry 1997;272(47):29579-83.
1997: Shinya Kuroda; Masaki Fukata; K Fujii; T Nakamura; I Izawa; Kozo Kaibuchi
Regulation of cell-cell adhesion of MDCK cells by Cdc42 and Rac1 small GTPases.
Biochemical and biophysical research communications 1997;240(2):430-5.
1997: K Nakai; Y Suzuki; H Kihira; Hideo Wada; M Fujioka; Masaaki Ito; Takeshi Nakano; Kozo Kaibuchi; Hiroshi Shiku; Masakatsu Nishikawa
Regulation of myosin phosphatase through phosphorylation of the myosin-binding subunit in platelet activation.
Blood 1997;90(10):3936-42.
1997: T Yamamoto; N Harada; K Kano; Shinichiro Taya; E Canaani; Y Matsuura; A Mizoguchi; C Ide; Kozo Kaibuchi
The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells.
The Journal of cell biology 1997;139(3):785-95.
1997: K Chihara; Mutsuki Amano; N Nakamura; T Yano; M Shibata; T Tokui; H Ichikawa; R Ikebe; M Ikebe; Kozo Kaibuchi
Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase.
The Journal of biological chemistry 1997;272(40):25121-7.
1997: Mariko Kobayashi; Satoshi Nagata; Yoshihiro Kita; N Nakatsu; Sayoko Ihara; Kozo Kaibuchi; S Kuroda; Michio Ui; Hideo Iba; H Konishi; U Kikkawa; I Saitoh; Yasuhisa Fukui
Expression of a constitutively active phosphatidylinositol 3-kinase induces process formation in rat PC12 cells. Use of Cre/loxP recombination system.
The Journal of biological chemistry 1997;272(26):16089-92.
1997: Yasuko Kureishi; S Kobayashi; M Amano; K Kimura; H Kanaide; Takeshi Nakano; Kozo Kaibuchi; Masaaki Ito
Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation.
The Journal of biological chemistry 1997;272(19):12257-60.
1997: Keiichi Tanaka; S Imajoh-Ohmi; T Sawada; R Shirai; Yuichi Hashimoto; S Iwasaki; Kozo Kaibuchi; Yasunori Kanaho; T Shirai; Yoshio Terada; K Kimura; Satoshi Nagata; Yasuhisa Fukui
A target of phosphatidylinositol 3,4,5-trisphosphate with a zinc finger motif similar to that of the ADP-ribosylation-factor GTPase-activating protein and two pleckstrin homology domains.
European journal of biochemistry / FEBS 1997;245(2):512-9.
1997: Mutsuki Amano; K Chihara; K Kimura; Yuko Fukata; N Nakamura; Y Matsuura; Kozo Kaibuchi
Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase.
Science (New York, N.Y.) 1997;275(5304):1308-11.
1997: Kozo Kaibuchi
[Regulation of cytoskeleton and cell adhesion by small GTPases].
Seikagaku. The Journal of Japanese Biochemical Society 1997;69(1):16-29.
1996: Shinya Kuroda; Masaki Fukata; K Kobayashi; M Nakafuku; N Nomura; Akihiro Iwamatsu; Kozo Kaibuchi
Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1.
The Journal of biological chemistry 1996;271(38):23363-7.
1996: Mutsuki Amano; M Ito; K Kimura; Yuko Fukata; K Chihara; T Nakano; Y Matsuura; Kozo Kaibuchi
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase).
The Journal of biological chemistry 1996;271(34):20246-9.
1996: K Kimura; M Ito; Mutsuki Amano; K Chihara; Yuko Fukata; M Nakafuku; B Yamamori; J Feng; T Nakano; K Okawa; Akihiro Iwamatsu; Kozo Kaibuchi
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
Science (New York, N.Y.) 1996;273(5272):245-8.
1996: T Matsui; Mutsuki Amano; T Yamamoto; K Chihara; M Nakafuku; M Ito; T Nakano; K Okawa; Akihiro Iwamatsu; Kozo Kaibuchi
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.
The EMBO journal 1996;15(9):2208-16.
1996: Mutsuki Amano; H Mukai; Y Ono; K Chihara; T Matsui; Y Hamajima; K Okawa; Akihiro Iwamatsu; Kozo Kaibuchi
Identification of a putative target for Rho as the serine-threonine kinase protein kinase N.
Science (New York, N.Y.) 1996;271(5249):648-50.
1996: M Kuriyama; N Harada; Shinya Kuroda; T Yamamoto; M Nakafuku; Akihiro Iwamatsu; D Yamamoto; R Prasad; C Croce; E Canaani; Kozo Kaibuchi
Identification of AF-6 and canoe as putative targets for Ras.
The Journal of biological chemistry 1996;271(2):607-10.
1995: T Yamamoto; T Matsui; M Nakafuku; Akihiro Iwamatsu; Kozo Kaibuchi
A novel GTPase-activating protein for R-Ras.
The Journal of biological chemistry 1995;270(51):30557-61.
1995: Shun'ichi Kuroda; Kazuya Shimizu; B Yamamori; S Matsuda; K Imazumi; Kozo Kaibuchi; Yoshimi Takai
Purification and characterization of REKS from Xenopus eggs. Identification of REKS as a Ras-dependent mitogen-activated protein kinase kinase kinase.
The Journal of biological chemistry 1995;270(6):2460-5.
1995: Yoshimi Takai; Kozo Kaibuchi; A Kikuchi; Takuya Sasaki
Effects of prenyl modifications on interactions of small G proteins with regulators.
Methods in enzymology 1995;250():122-33.
1994: M Miyazaki; H Shirataki; H Kohno; Kozo Kaibuchi; A Tsugita; Yoshimi Takai
Identification as beta-adducin of a protein interacting with rabphilin-3A in the presence of Ca2+ and phosphatidylserine.
Biochemical and biophysical research communications 1994;205(1):460-6.
1994: Kazuya Shimizu; Shun'ichi Kuroda; B Yamamori; S Matsuda; Kozo Kaibuchi; T Yamauchi; T Isobe; K Irie; K Matsumoto; Yoshimi Takai
Synergistic activation by Ras and 14-3-3 protein of a mitogen-activated protein kinase kinase kinase named Ras-dependent extracellular signal-regulated kinase kinase stimulator.
The Journal of biological chemistry 1994;269(37):22917-20.