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Bernd Kaina

Research Profile

Chemicals & Drugs

Physiology

Disorders

DNA Damage

Living Beings

Anatomy

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Ultraviolet Rays

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TOP 3
Wynand P Roos; Bernd Kaina
DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis.
Dagmar Faust; Eva Hrubá; Petra Hulinková; Bernd Kaina; Pavel Krčmář; Jiřina Procházková; Lenka Smerdová; Jan Vondráček; Cornelia Dietrich; Miroslav Machala
AhR-mediated changes in global gene expression in rat liver progenitor cells.
Adam D Thomas; Karl-Heinz Tomaszowski; Bernd Kaina; Paul D Lewis; Owen G Bodger; Shareen H Doak; G J S Jenkins; George E Johnson
Influence of DNA repair on nonlinear dose-responses for mutation.

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All Publications

2013: Wynand P Roos; Bernd Kaina
DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis.
Cancer letters 2013;332(2):237-48.
2013: Dagmar Faust; Eva Hrubá; Petra Hulinková; Bernd Kaina; Pavel Krčmář; Jiřina Procházková; Lenka Smerdová; Jan Vondráček; Cornelia Dietrich; Miroslav Machala
AhR-mediated changes in global gene expression in rat liver progenitor cells.
Archives of toxicology 2013;87(4):681-98.
2013: Adam D Thomas; Karl-Heinz Tomaszowski; Bernd Kaina; Paul D Lewis; Owen G Bodger; Shareen H Doak; G J S Jenkins; George E Johnson
Influence of DNA repair on nonlinear dose-responses for mutation.
Toxicological sciences : an official journal of the Society of Toxicology 2013;132(1):87-95.
2013: Anna V Knizhnik; Teodora Nikolova; Steve Quiros; Wynand P Roos; Karl-Heinz Tomaszowski; Markus Christmann; Bernd Kaina
Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage.
PloS one 2013;8(1):e55665.
2013: Maja T Tomicic; Bernd Kaina
Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors.
Biochimica et biophysica acta 2013;1835(1):11-27.
2012: Stefanie C Huelsenbeck; Bernd Kaina; Wynand P Roos; Anne Schorr; Christian Henninger; Johannes Huelsenbeck; Gerhard Fritz
Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.
The Journal of biological chemistry 2012;287(46):38590-9.
2012: Terezie T Mosby; Karl L Platt; Samiramis Sarkardei; Maeve Cosgrove; Bernd Kaina
Nutrition in adult and childhood cancer: role of carcinogens and anti-carcinogens.
Anticancer research 2012;32(10):4171-92.
2012: Markus Christmann; Bernd Kaina
O(6)-methylguanine-DNA methyltransferase (MGMT): impact on cancer risk in response to tobacco smoke.
Mutation research 2012;736(1-2):64-74.
2012: Teodora Nikolova; Anita Bhatti; Frank Hennekes; Bernd Kaina
Chloroethylnitrosourea-induced cell death and genotoxicity: cell cycle dependence and the role of DNA double-strand breaks, HR and NHEJ.
Cell cycle (Georgetown, Tex.) 2012;11(14):2606-19.
2012: Ruth Meise; Maja T Tomicic; Bernd Kaina; Markus Christmann
The chloroethylating anticancer drug ACNU induces FRA1 that is involved in drug resistance of glioma cells.
Biochimica et biophysica acta 2012;1823(7):1199-207.
2012: Herwig M Strik; Bernd Kaina; Christine Marosi; Bart Neyns
Temozolomide dosing regimens for glioma patients.
Current neurology and neuroscience reports 2012;12(3):286-93.
2012: Christian Henninger; Johannes Huelsenbeck; Stefanie Huelsenbeck; Bernd Kaina; Karl J Lackner; Arno Schad; Sabine Grösch; Gerhard Fritz
The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity.
Toxicology and applied pharmacology 2012;261(1):66-73.
2012: Martina Bauer; Michael Goldstein; Daniel Heylmann; Bernd Kaina
Human monocytes undergo excessive apoptosis following temozolomide activating the ATM/ATR pathway while dendritic cells and macrophages are resistant.
PloS one 2012;7(6):e39956.
2011: Markus Christmann; Wynand Roos; Barbara Verbeek; Bernd Kaina
O(6)-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: enzyme activity, promoter methylation and immunohistochemistry.
Biochimica et biophysica acta 2011;1816(2):179-90.
2011: Sebastian Reichert; Claus Rödel; Maja T Tomicic; Patrick N Harter; Bernd Kaina; Johanna Mirsch; Michel Mittelbronn; Franz Rödel
Survivin inhibition and DNA double-strand break repair: a molecular mechanism to overcome radioresistance in glioblastoma.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011;101(1):51-8.
2011: Wynand Roos; Georg Nagel; Christina Belohlavek; Gerhard Fritz; Eva Jöst; Bernd Kaina
Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-β and valproic acid.
Cancer research 2011;71(12):4150-60.
2011: Maja T Tomicic; Patricia Reischmann; Birgit Rasenberger; Ruth Meise; Bernd Kaina; Markus Christmann
Delayed c-Fos activation in human cells triggers XPF induction and an adaptive response to UVC-induced DNA damage and cytotoxicity.
Cellular and molecular life sciences : CMLS 2011;68(10):1785-98.
2011: Lars Helbig; Julia Damrot; Johannes Hülsenbeck; Beate Köberle; Anamaria Brozovic; Maja Osmak; Zeljka Fiket; Bernd Kaina; Gerhard Fritz
Late activation of stress-activated protein kinases/c-Jun N-terminal kinases triggered by cisplatin-induced DNA damage in repair-defective cells.
The Journal of biological chemistry 2011;286(15):12991-3001.
2011: Davide Sciuscio; Annie-Claire Diserens; Kristof van Dommelen; Danielle Martinet; Greg Jones; Robert-Charles Janzer; Claudio Pollo; Marie-France Hamou; Bernd Kaina; Roger Stupp; Marc Levivier; Monika E Hegi
Extent and patterns of MGMT promoter methylation in glioblastoma- and respective glioblastoma-derived spheres.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(2):255-66.
2011: Steve Quiros; Wynand Roos; Bernd Kaina
Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.
PloS one 2011;6(11):e27183.
2011: Melanie Hamalukic; Johannes Huelsenbeck; Bernd Kaina; Arno Schad; Stefan Wirtz; Gerhard Fritz
Rac1-regulated endothelial radiation response stimulates extravasation and metastasis that can be blocked by HMG-CoA reductase inhibitors.
PloS one 2011;6(10):e26413.
2010: Stefan Wirtz; Georg Nagel; Leonid Eshkind; Markus F Neurath; Leona D Samson; Bernd Kaina
Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.
Carcinogenesis 2010;31(12):2111-7.
2010: Beate Köberle; Maja T Tomicic; Svetlana Usanova; Bernd Kaina
Cisplatin resistance: preclinical findings and clinical implications.
Biochimica et biophysica acta 2010;1806(2):172-82.
2010: Marcus Eich; Wynand Roos; Grigory L Dianov; Martin Digweed; Bernd Kaina
Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide.
Molecular pharmacology 2010;78(5):943-51.
2010: Bernd Kaina; Geoffrey P Margison; Markus Christmann
Targeting O⁶-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy.
Cellular and molecular life sciences : CMLS 2010;67(21):3663-81.
2010: Markus Christmann; Georg Nagel; Sigrid Horn; Ulrike Krahn; Dorothee Wiewrodt; Clemens Sommer; Bernd Kaina
MGMT activity, promoter methylation and immunohistochemistry of pretreatment and recurrent malignant gliomas: a comparative study on astrocytoma and glioblastoma.
International journal of cancer. Journal international du cancer 2010;127(9):2106-18.
2010: Teodora Nikolova; Michael Ensminger; Markus Löbrich; Bernd Kaina
Homologous recombination protects mammalian cells from replication-associated DNA double-strand breaks arising in response to methyl methanesulfonate.
DNA repair 2010;9(10):1050-63.
2010: Markus Christmann; Maja T Tomicic; Dorthe Aasland; Nicole Berdelle; Bernd Kaina
Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage.
Nucleic acids research 2010;38(19):6418-32.
2010: Eva Jöst; Wynand Roos; Bernd Kaina; Heinz Schmidberger
Response of pancreatic cancer cells treated with interferon-alpha or beta and co-exposed to ionising radiation.
International journal of radiation biology 2010;86(9):732-41.
2010: Cornelia Dietrich; Bernd Kaina
The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth.
Carcinogenesis 2010;31(8):1319-28.
2010: Fanny Lemée; Valérie Bergoglio; Anne Fernandez-Vidal; Alice Machado-Silva; Marie-Jeanne Pillaire; Anne Bieth; Catherine Gentil; Lee Baker; Anne-Laure Martin; Claire Leduc; Elena Lam; Eddy Magdeleine; Thomas Filleron; Naïma Oumouhou; Bernd Kaina; Mineaki Seki; Fanny Grimal; Magali Lacroix-Triki; Alastair Thompson; Henri Roché; Jean-Christophe Bourdon; Richard D Wood; Jean-Sébastien Hoffmann; Christophe Cazaux
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(30):13390-5.
2010: Roland Jacob; Navid Shafiei; Georg Nagel; Hans Jürgen Welkoborsky; Wolf Mann; Bernd Kaina
MGMT activity in mucosal epithelium and squamous cell carcinoma of the head and neck.
Anticancer research 2010;30(7):2561-6.
2010: Thomas Efferth; Bernd Kaina
Toxicity of the antimalarial artemisinin and its dervatives.
Critical reviews in toxicology 2010;40(5):405-21.
2010: Svetlana Usanova; Andrea Piée-Staffa; Ulrike Sied; Jürgen Thomale; Astrid Schneider; Bernd Kaina; Beate Köberle
Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression.
Molecular cancer 2010;9():248.
2010: Steve Quiros; Wynand Roos; Bernd Kaina
Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles.
Cell cycle (Georgetown, Tex.) 2010;9(1):168-78.
2010: Beate Köberle; Walburgis Brenner; Andreas Albers; Svetlana Usanova; Joachim W Thüroff; Bernd Kaina
ERCC1 and XPF expression in human testicular germ cell tumors.
Oncology reports 2010;23(1):223-7.
2010: Maja T Tomicic; Markus Christmann; Bernd Kaina
Topotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3-mediated Bid cleavage.
The Journal of pharmacology and experimental therapeutics 2010;332(1):316-25.
2009: Anamaria Brozovic; Julia Damrot; Roman Tsaryk; Lars Helbig; Teodora Nikolova; Cornelia Hartig; Maja Osmak; Wynand Roos; Bernd Kaina; Gerhard Fritz
Cisplatin sensitivity is related to late DNA damage processing and checkpoint control rather than to the early DNA damage response.
Mutation research 2009;670(1-2):32-41.
2009: Wynand Roos; Anastasia Tsaalbi-Shtylik; Roman Tsaryk; Fatma Güvercin; Niels De Wind; Bernd Kaina
The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs.
Molecular pharmacology 2009;76(4):927-34.
2009: Ernesto Bockamp; Cecilia Antunes; Stefan Liebner; Steffen Schmitt; Nina Cabezas-Wallscheid; Rosario Heck; Svetlana Ohnngemach; Barbara Oesch-Bartlomowicz; Christof Rickert; Maria José Sanchez; Jan G Hengstler; Bernd Kaina; Anne Wilson; Andreas Trumpp; Leonid Eshkind
In vivo fate mapping with SCL regulatory elements identifies progenitors for primitive and definitive hematopoiesis in mice.
Mechanisms of development 2009;126(10):863-72.
2009: Teodora Nikolova; Markus Christmann; Bernd Kaina
FEN1 is overexpressed in testis, lung and brain tumors.
Anticancer research 2009;29(7):2453-9.
2009: Luís F Z Batista; Bernd Kaina; Rogério Meneghini; Carlos F M Menck
How DNA lesions are turned into powerful killing structures: insights from UV-induced apoptosis.
Mutation research 2009;681(2-3):197-208.
2009: Julia Damrot; Lars Helbig; Wynand Roos; Steve Q Barrantes; Bernd Kaina; Gerhard Fritz
DNA replication arrest in response to genotoxic stress provokes early activation of stress-activated protein kinases (SAPK/JNK).
Journal of molecular biology 2009;385(5):1409-21.
2009: Luis F Z Batista; Wynand Roos; Bernd Kaina; Carlos F M Menck
p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal.
Molecular cancer research : MCR 2009;7(2):237-46.
2009: Steffen Naumann; Wynand Roos; E Jöst; C Belohlavek; Volker Lennerz; C W Schmidt; Markus Christmann; Bernd Kaina
Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53.
British journal of cancer 2009;100(2):322-33.
2009: Wynand Roos; Teodora Nikolova; Steve Quiros; Steffen Naumann; Olivia Kiedron; Malgorzata Z Zdzienicka; Bernd Kaina
Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs.
DNA repair 2009;8(1):72-86.
2008: Markus Christmann; Maja T Tomicic; Christopher Gestrich; Wynand Roos; Vilhelm A Bohr; Bernd Kaina
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation.
DNA repair 2008;7(12):1999-2009.
2008: Ori Staszewski; Teodora Nikolova; Bernd Kaina
Kinetics of gamma-H2AX focus formation upon treatment of cells with UV light and alkylating agents.
Environmental and molecular mutagenesis 2008;49(9):734-40.
2008: Verena Voelter; Annie-Claire Diserens; Alexandre Moulin; Georg Nagel; Pu Yan; Eugenia Migliavacca; Donata Rimoldi; Marie-France Hamou; Bernd Kaina; Serge Leyvraz; Monika E Hegi
Infrequent promoter methylation of the MGMT gene in liver metastases from uveal melanoma.
International journal of cancer. Journal international du cancer 2008;123(5):1215-8.
2008: Paul C H Li; Elena Lam; Wynand Roos; Malgorzata Z Zdzienicka; Bernd Kaina; Thomas Efferth
Artesunate derived from traditional Chinese medicine induces DNA damage and repair.
Cancer research 2008;68(11):4347-51.
2008: Michael Goldstein; Wynand Roos; Bernd Kaina
Apoptotic death induced by the cyclophosphamide analogue mafosfamide in human lymphoblastoid cells: contribution of DNA replication, transcription inhibition and Chk/p53 signaling.
Toxicology and applied pharmacology 2008;229(1):20-32.
2008: Badireenath Konkimalla; Bernd Kaina; Thomas Efferth
Role of transporter genes in cisplatin resistance.
In vivo (Athens, Greece) 2008;22(3):279-83.
2008: Dorothee Wiewrodt; Georg Nagel; Nadine Dreimüller; Thomas Hundsberger; Axel Perneczky; Bernd Kaina
MGMT in primary and recurrent human glioblastomas after radiation and chemotherapy and comparison with p53 status and clinical outcome.
International journal of cancer. Journal international du cancer 2008;122(6):1391-9.
2008: Badireenath Konkimalla; Gan Wang; Bernd Kaina; Thomas Efferth
Microarray-based expression of DNA repair genes does not correlate with growth inhibition of cancer cells by natural products derived from traditional Chinese medicine.
Cancer genomics & proteomics 2008;5(2):79-84.
2008: Thomas Efferth; Stefan Kahl; Kerstin Paulus; Michael Adams; Rolf Rauh; Herbert Boechzelt; Xiaojiang Hao; Bernd Kaina; Rudolf Bauer
Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells.
Molecular cancer therapeutics 2008;7(1):152-61.
2007: Luis Batista; Wynand Roos; Markus Christmann; Carlos F M Menck; Bernd Kaina
Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks.
Cancer research 2007;67(24):11886-95.
2007: Manuela Briegert; Alexander H Enk; Bernd Kaina
Change in expression of MGMT during maturation of human monocytes into dendritic cells.
DNA repair 2007;6(9):1255-63.
2007: Amélie Rebillard; Xavier Tekpli; Olivier Meurette; Odile Sergent; Gwenaëlle LeMoigne-Muller; Laurent Vernhet; Morgane Gorria; Martine Chevanne; Markus Christmann; Bernd Kaina; Laurent Counillon; Erich Gulbins; Dominique Lagadic-Gossmann; Marie-Thérèse Dimanche-Boitrel
Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells.
Cancer research 2007;67(16):7865-74.
2007: Thomas Efferth; Paul C H Li; Badireenath Konkimalla; Bernd Kaina
From traditional Chinese medicine to rational cancer therapy.
Trends in molecular medicine 2007;13(8):353-61.
2007: Bernd Kaina; Markus Christmann; Steffen Naumann; Wynand Roos
MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.
DNA repair 2007;6(8):1079-99.
2007: Wynand Roos; Markus Christmann; S T Fraser; Bernd Kaina
Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair.
Cell death and differentiation 2007;14(8):1422-32.
2007: Ernesto Bockamp; Cerstin Christel; Dorothe Hameyer; Andriy Khobta; Marko Maringer; Marco Reis; Rosario Heck; Nina Cabezas-Wallscheid; Bernd Epe; Barbara Oesch-Bartlomowicz; Bernd Kaina; Steffen Schmitt; Leonid Eshkind
Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system.
The journal of gene medicine 2007;9(4):308-18.
2007: Dorothee Koch; Thomas Hundsberger; Stephan Boor; Bernd Kaina
Local intracerebral administration of O(6)-benzylguanine combined with systemic chemotherapy with temozolomide of a patient suffering from a recurrent glioblastoma.
Journal of neuro-oncology 2007;82(1):85-9.
2007: Wynand Roos; Luis Batista; Steffen Naumann; W Wick; Michael Weller; Carlos F M Menck; Bernd Kaina
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.
Oncogene 2007;26(2):186-97.
2007: Rolf Rauh; Stefan Kahl; Herbert Boechzelt; Rudolf Bauer; Bernd Kaina; Thomas Efferth
Molecular biology of cantharidin in cancer cells.
Chinese medicine 2007;2():8.
2007: Manuela Briegert; Bernd Kaina
Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents.
Cancer research 2007;67(1):26-31.
2007: Markus Christmann; Maja T Tomicic; Dorthe Aasland; Bernd Kaina
A role for UV-light-induced c-Fos: Stimulation of nucleotide excision repair and protection against sustained JNK activation and apoptosis.
Carcinogenesis 2007;28(1):183-90.
2006: J Damrot; Tobias Nübel; Bernd Epe; Wynand Roos; Bernd Kaina; Gerhard Fritz
Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide.
British journal of pharmacology 2006;149(8):988-97.
2006: Wynand Roos; Bernd Kaina
DNA damage-induced cell death by apoptosis.
Trends in molecular medicine 2006;12(9):440-50.
2006: Ernesto Bockamp; Cecilia Antunes; Marko Maringer; Rosario Heck; Katrin Presser; Sven Beilke; Svetlana Ohngemach; Rudiger Alt; Michael Cross; Rolf Sprengel; Udo Hartwig; Bernd Kaina; Steffen Schmitt; Leonid Eshkind
Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes, and c-kit-expressing lineage-negative hematopoietic cells.
Blood 2006;108(5):1533-41.
2006: Roman Tsaryk; Kerstin Fabian; John Thacker; Bernd Kaina
Xrcc2 deficiency sensitizes cells to apoptosis by MNNG and the alkylating anticancer drugs temozolomide, fotemustine and mafosfamide.
Cancer letters 2006;239(2):305-13.
2006: Martin Holtmann; Bernd Kaina; Fritz Poustka
[Methylphenidate-induced cytogenetic alterations?].
Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie 2006;34(3):215-20.
2006: Gerhard Fritz; Bernd Kaina
Rho GTPases: promising cellular targets for novel anticancer drugs.
Current cancer drug targets 2006;6(1):1-14.
2006: Tobias Nübel; Julia Damrot; Wynand Roos; Bernd Kaina; Gerhard Fritz
Lovastatin protects human endothelial cells from killing by ionizing radiation without impairing induction and repair of DNA double-strand breaks.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(3 Pt 1):933-9.
2006: Mirjam Hermisson; Andrea Klumpp; Wolfgang Wick; Jörg Wischhusen; Georg Nagel; Wynand Roos; Bernd Kaina; Michael Weller
O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells.
Journal of neurochemistry 2006;96(3):766-76.
2006: Gerhard Fritz; Bernd Kaina
Late activation of stress kinases (SAPK/JNK) by genotoxins requires the DNA repair proteins DNA-PKcs and CSB.
Molecular biology of the cell 2006;17(2):851-61.
2006: Ute Mühlhausen; Ralf Schirrmacher; Markus Piel; Bernd Lecher; Manuela Briegert; Andrea Piee-Staffa; Bernd Kaina; Frank Rösch
Synthesis of 131I-labeled glucose-conjugated inhibitors of O6-methylguanine-DNA methyltransferase (MGMT) and comparison with nonconjugated inhibitors as potential tools for in vivo MGMT imaging.
Journal of medicinal chemistry 2006;49(1):263-72.
2006: Markus Christmann; Maja T Tomicic; Judith Origer; Dorthe Aasland; Bernd Kaina
c-Fos is required for excision repair of UV-light induced DNA lesions by triggering the re-synthesis of XPF.
Nucleic acids research 2006;34(22):6530-9.
2005: Markus Christmann; Maja T Tomicic; Judith Origer; Bernd Kaina
Fen1 is induced p53 dependently and involved in the recovery from UV-light-induced replication inhibition.
Oncogene 2005;24(56):8304-13.
2005: Tobias Nübel; Steffen Schmitt; Bernd Kaina; Gerhard Fritz
Lovastatin stimulates p75 TNF receptor (TNFR2) expression in primary human endothelial cells.
International journal of molecular medicine 2005;16(6):1139-45.
2005: Maja T Tomicic; Markus Christmann; Bernd Kaina
Apoptosis in UV-C light irradiated p53 wild-type, apaf-1 and p53 knockout mouse embryonic fibroblasts: interplay of receptor and mitochondrial pathway.
Apoptosis : an international journal on programmed cell death 2005;10(6):1295-304.
2005: Maja T Tomicic; Markus Christmann; Bernd Kaina
Topotecan-triggered degradation of topoisomerase I is p53-dependent and impacts cell survival.
Cancer research 2005;65(19):8920-6.
2005: Sonja M Schwarzl; Jeremy Smith; Bernd Kaina; Thomas Efferth
Molecular modeling of O6-methylguanine-DNA methyltransferase mutant proteins encoded by single nucleotide polymorphisms.
International journal of molecular medicine 2005;16(4):553-7.
2005: Maja T Tomicic; Markus Christmann; Kerstin Fabian; Bernd Kaina
Apaf-1 deficient mouse fibroblasts are resistant to MNNG and MMS-induced apoptotic death without attenuation of Bcl-2 decline.
Toxicology and applied pharmacology 2005;207(2 Suppl):117-22.
2005: Thomas Efferth; Rolf Rauh; Stefan Kahl; Maja T Tomicic; Herbert Böchzelt; Margaret E Tome; Margaret M Briehl; Rudolf Bauer; Bernd Kaina
Molecular modes of action of cantharidin in tumor cells.
Biochemical pharmacology 2005;69(5):811-8.
2004: Anamaria Brozovic; Gerhard Fritz; Markus Christmann; Jochen Zisowsky; Ulrich Jaehde; Maja Osmak; Bernd Kaina
Long-term activation of SAPK/JNK, p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance.
International journal of cancer. Journal international du cancer 2004;112(6):974-85.
2004: Bernd Kaina; Ute Mühlhausen; Andrea Piee-Staffa; Markus Christmann; Regine Garcia Boy; Frank Rösch; Ralf Schirrmacher
Inhibition of O6-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors: comparison with nonconjugated inhibitors and effect on fotemustine and temozolomide-induced cell death.
The Journal of pharmacology and experimental therapeutics 2004;311(2):585-93.
2004: Thomas Efferth; Achille Benakis; Marta R Romero; Maja T Tomicic; Rolf Rauh; Daniel Steinbach; Ralf Häfer; Thomas Stamminger; Franz Oesch; Bernd Kaina; Manfred Marschall
Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron.
Free radical biology & medicine 2004;37(7):998-1009.
2004: Tobias Nübel; Wolfgang Dippold; Bernd Kaina; Gerhard Fritz
Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid.
Carcinogenesis 2004;25(8):1335-44.
2004: Malgorzata Debiak; Teodora Nikolova; Bernd Kaina
Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations.
DNA repair 2004;3(4):359-68.
2004: Berno Tanner; Stephan Grimme; Ilka B Schiffer; Carolin K Heimerdinger; Markus Schmidt; Philipp Dutkowski; Susanne Neubert; Franz Oesch; Arno Franzen; Heinz Kölbl; Gerhard Fritz; Bernd Kaina; Jan G Hengstler
Nuclear expression of apurinic/apyrimidinic endonuclease increases with progression of ovarian carcinomas.
Gynecologic oncology 2004;92(2):568-77.
2004: Wynand Roos; Manuela Baumgartner; Bernd Kaina
Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.
Oncogene 2004;23(2):359-67.
2004: Bernd Kaina
Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go.
Cytogenetic and genome research 2004;104(1-4):77-86.
2004: Susanne Brendler-Schwaab; Andreas Czich; Bernd Epe; Elmar Gocke; Bernd Kaina; Lutz Müller; Dieter Pollet; Dietmar Utesch
Photochemical genotoxicity: principles and test methods. Report of a GUM task force.
Mutation research 2004;566(1):65-91.
2004: Rudolf Thust; Maja T Tomicic; Rolf Gräbner; Claudia Friedrichs; Peter Wutzler; Bernd Kaina
Cytogenetic detection of a trans-species bystander effect: induction of sister chromatid exchanges in murine 3T3 cells by ganciclovir metabolized in HSV thymidine kinase gene-transfected Chinese hamster ovary cells.
Mutagenesis 2004;19(1):27-33.
2004: Tobias Nübel; Wolfgang Dippold; Hartmut Kleinert; Bernd Kaina; Gerhard Fritz
Lovastatin inhibits Rho-regulated expression of E-selectin by TNFalpha and attenuates tumor cell adhesion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):140-2.
2003: Gerhard Fritz; Sabine Grösch; Maja T Tomicic; Bernd Kaina
APE/Ref-1 and the mammalian response to genotoxic stress.
Toxicology 2003;193(1-2):67-78.
2003: Markus Christmann; Maja T Tomicic; Wynand Roos; Bernd Kaina
Mechanisms of human DNA repair: an update.
Toxicology 2003;193(1-2):3-34.
2003: Bernd Kaina
On the 50th anniversary of the elucidation of the DNA structure.
Toxicology 2003;193(1-2):1-2.
2003: Torsten R Dunkern; Wynand Roos; Bernd Kaina
Apoptosis induced by MNNG in human TK6 lymphoblastoid cells is p53 and Fas/CD95/Apo-1 related.
Mutation research 2003;544(2-3):167-72.
2003: Bernd Kaina
DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling.
Biochemical pharmacology 2003;66(8):1547-54.
2003: Georg Nagel; Walburgis Brenner; Kai Johnsson; Bernd Kaina
DNA repair protein O6-methylguanine-DNA methyltransferase in testis and testicular tumors as determined by a novel nonradioactive assay.
Analytical biochemistry 2003;321(1):38-43.
2003: Gerhard Fritz; C Brachetti; Bernd Kaina
Lovastatin causes sensitization of HeLa cells to ionizing radiation-induced apoptosis by the abrogation of G2 blockage.
International journal of radiation biology 2003;79(8):601-10.
2003: Renate v Bardeleben; Bernd Kaina; Gerhard Fritz
Ultraviolet light-induced apoptotic death is impaired by the HMG-CoA reductase inhibitor lovastatin.
Biochemical and biophysical research communications 2003;307(2):401-7.
2003: Geoffrey P Margison; Andrew C Povey; Bernd Kaina; Mauro F Santibáñez-Koref
Variability and regulation of O6-alkylguanine-DNA alkyltransferase.
Carcinogenesis 2003;24(4):625-35.
2003: Klaus Becker; Cornelia Gregel; Christa Fricke; Dymitr Komitowski; Jörg Dosch; Bernd Kaina
DNA repair protein MGMT protects against N-methyl-N-nitrosourea-induced conversion of benign into malignant tumors.
Carcinogenesis 2003;24(3):541-6.
2003: Maja T Tomicic; Claudia Friedrichs; Markus Christmann; Peter Wutzler; Rudolf Thust; Bernd Kaina
Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8.
Molecular pharmacology 2003;63(2):439-49.
2003: Wolfgang W Huber; Gerlinde Scharf; Georg Nagel; Sonja Prustomersky; Rolf Schulte-Hermann; Bernd Kaina
Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver--comparison with phase II xenobiotic metabolism.
Mutation research 2003;522(1-2):57-68.
2003: Torsten R Dunkern; Inga Wedemeyer; Manuela Baumgärtner; Gerhard Fritz; Bernd Kaina
Resistance of p53 knockout cells to doxorubicin is related to reduced formation of DNA strand breaks rather than impaired apoptotic signaling.
DNA repair 2003;2(1):49-60.
2002: Renate V Bardeleben; Torsten R Dunkern; Bernd Kaina; Gerhard Fritz
The HMG-CoA reductase inhibitor lovastatin protects cells from the antineoplastic drugs doxorubicin and etoposide.
International journal of molecular medicine 2002;10(4):473-9.
2002: Gerhard Fritz; C Brachetti; F Bahlmann; Martina Schmidt; Bernd Kaina
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters.
British journal of cancer 2002;87(6):635-44.
2002: Maja T Tomicic; Erato Bey; Peter Wutzler; Rudolf Thust; Bernd Kaina
Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir.
Mutation research 2002;505(1-2):1-11.
2002: Bernd Kaina; Markus Christmann
DNA repair in resistance to alkylating anticancer drugs.
International journal of clinical pharmacology and therapeutics 2002;40(8):354-67.
2002: Katherine J Kim; Indraneel Chakrabarty; Guang-Zhi Li; Sabine Grösch; Bernd Kaina; Thomas M. Ruenger
Modulation of base excision repair alters cellular sensitivity to UVA1 but not to UVB1.
Photochemistry and photobiology 2002;75(5):507-12.
2002: Markus Christmann; Maja T Tomicic; Bernd Kaina
Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutSalpha mismatch-binding activity.
Nucleic acids research 2002;30(9):1959-66.
2002: Maja T Tomicic; Rudolf Thust; Bernd Kaina
Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation.
Oncogene 2002;21(14):2141-53.
2002: Ralf Schirrmacher; Esther Nesseler; Wilhelm Hamkens; Uta Eichhorn; Mathias Schreckenberger; Bernd Kaina; Frank Rösch
An approach to the evaluation of the activity of the DNA repair enzyme O6-methylguanine-DNA-methyl-transferase in tumor tissue in vivo: syntheses of 6-benzyloxy-9-(2-[18F]fluoroethyl)-9H-purin-2-yl-amine and 6-benzyloxy-7-(2-[18F]fluoroethyl)-7H-purin-2-yl-amine.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2002;56(3):511-7.
2002: Kirsten Ochs; Jochen Lips; Simone Profittlich; Bernd Kaina
Deficiency in DNA polymerase beta provokes replication-dependent apoptosis via DNA breakage, Bcl-2 decline and caspase-3/9 activation.
Cancer research 2002;62(5):1524-30.
2002: R Becker; A Ritter; Uta Eichhorn; Jochen Lips; Barbara Bertram; M Wiessler; M Z Zdzienicka; Bernd Kaina
Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug beta-D-glucosyl-ifosfamide mustard.
British journal of cancer 2002;86(1):130-5.
2002: Torsten R Dunkern; Bernd Kaina
Cell proliferation and DNA breaks are involved in ultraviolet light-induced apoptosis in nucleotide excision repair-deficient Chinese hamster cells.
Molecular biology of the cell 2002;13(1):348-61.
2001: J Reinhard; William E Hull; Claus-W von der Lieth; Uta Eichhorn; Hans-Christian Kliem; Bernd Kaina; Manfred Wiessler
Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships.
Journal of medicinal chemistry 2001;44(24):4050-61.
2001: Jochen Lips; Bernd Kaina
Repair of O(6)-methylguanine is not affected by thymine base pairing and the presence of MMR proteins.
Mutation research 2001;487(1-2):59-66.
2001: Maja T Tomicic; Rudolf Thust; Robert W Sobol; Bernd Kaina
DNA polymerase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage.
Cancer research 2001;61(20):7399-403.
2001: Torsten R Dunkern; Gerhard Fritz; Bernd Kaina
Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation.
Oncogene 2001;20(42):6026-38.
2001: Torsten R Dunkern; Gerhard Fritz; Bernd Kaina
Cisplatin-induced apoptosis in 43-3B and 27-1 cells defective in nucleotide excision repair.
Mutation research 2001;486(4):249-58.
2001: Kai Janssen; Kirsten Schlink; W Götte; B Hippler; Bernd Kaina; Franz Oesch
DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326.
Mutation research 2001;486(3):207-16.
2001: J Reinhard; Uta Eichhorn; Manfred Wiessler; Bernd Kaina
Inactivation of O(6)-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors.
International journal of cancer. Journal international du cancer 2001;93(3):373-9.
2001: Kai Janssen; U Eichhorn-Grombacher; Kirsten Schlink; S Nitzsche; Franz Oesch; Bernd Kaina
Long-time expression of DNA repair enzymes MGMT and APE in human peripheral blood mononuclear cells.
Archives of toxicology 2001;75(5):306-12.
2001: D Lackinger; Uta Eichhorn; Bernd Kaina
Effect of ultraviolet light, methyl methanesulfonate and ionizing radiation on the genotoxic response and apoptosis of mouse fibroblasts lacking c-Fos, p53 or both.
Mutagenesis 2001;16(3):233-41.
2001: Jochen Lips; Bernd Kaina
DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts.
Carcinogenesis 2001;22(4):579-85.
2001: Markus Christmann; M Pick; Hermann Lage; Dirk Schadendorf; Bernd Kaina
Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT.
International journal of cancer. Journal international du cancer 2001;92(1):123-9.
2001: R Gnad; Bernd Kaina; Gerhard Fritz
Rho GTPases are involved in the regulation of NF-kappaB by genotoxic stress.
Experimental cell research 2001;264(2):244-9.
2001: Jan G Hengstler; Henryk Pilch; Martina Schmidt; H Dahlenburg; Jens Sagemüller; Ilka B Schiffer; Franz Oesch; Paul Georg Knapstein; Bernd Kaina; Berno Tanner
Metallothionein expression in ovarian cancer in relation to histopathological parameters and molecular markers of prognosis.
International journal of cancer. Journal international du cancer 2001;95(2):121-7.
2001: Maja T Tomicic; Bernd Kaina
Hamster Bcl-2 protein is cleaved in vitro and in cells by caspase-9 and caspase-3.
Biochemical and biophysical research communications 2001;281(2):404-8.
2001: Gerhard Fritz; Bernd Kaina
Ras-related GTPase Rhob represses NF-kappaB signaling.
The Journal of biological chemistry 2001;276(5):3115-22.
2001: Gerhard Fritz; Bernd Kaina
Transcriptional activation of the small GTPase gene rhoB by genotoxic stress is regulated via a CCAAT element.
Nucleic acids research 2001;29(3):792-8.
2001: Bernd Kaina; Kirsten Ochs; Sabine Grösch; Gerhard Fritz; Jochen Lips; Maja T Tomicic; Torsten R Dunkern; Markus Christmann
BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis.
Progress in nucleic acid research and molecular biology 2001;68():41-54.
2000: D Lackinger; Bernd Kaina
Primary mouse fibroblasts deficient for c-Fos, p53 or for both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis.
Mutation research 2000;457(1-2):113-23.
2000: R Gnad; K Aktories; Bernd Kaina; Gerhard Fritz
Inhibition of protein isoprenylation impairs rho-regulated early cellular response to genotoxic stress.
Molecular pharmacology 2000;58(6):1389-97.
2000: Markus Christmann; Bernd Kaina
Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents.
The Journal of biological chemistry 2000;275(46):36256-62.
2000: Kirsten Ochs; Bernd Kaina
Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent.
Cancer research 2000;60(20):5815-24.
2000: Günter Speit; Claudia Dennog; Uta Eichhorn; Andreas Rothfuss; Bernd Kaina
Induction of heme oxygenase-1 and adaptive protection against the induction of DNA damage after hyperbaric oxygen treatment.
Carcinogenesis 2000;21(10):1795-9.
2000: Maja T Tomicic; Markus Christmann; Bernd Kaina
Cloning and functional analysis of cDNA encoding the hamster Bcl-2 protein.
Biochemical and biophysical research communications 2000;275(3):899-903.
2000: Rudolf Thust; Maja T Tomicic; R Klöcking; Peter Wutzler; Bernd Kaina
Cytogenetic genotoxicity of anti-herpes purine nucleoside analogues in CHO cells expressing the thymidine kinase gene of herpes simplex virus type 1: comparison of ganciclovir, penciclovir and aciclovir.
Mutagenesis 2000;15(2):177-84.
2000: Gerhard Fritz; Bernd Kaina
Ras-related GTPase RhoB forces alkylation-induced apoptotic cell death.
Biochemical and biophysical research communications 2000;268(3):784-9.
2000: H Seker; Barbara Bertram; Alexander Bürkle; Bernd Kaina; J Pohl; H Koepsell; M Wiesser
Mechanistic aspects of the cytotoxic activity of glufosfamide, a new tumour therapeutic agent.
British journal of cancer 2000;82(3):629-34.
2000: Rudolf Thust; Maja T Tomicic; R Klöcking; N Voutilainen; Peter Wutzler; Bernd Kaina
Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: implications for gene therapeutic approaches.
Cancer gene therapy 2000;7(1):107-17.
1999: Jan G Hengstler; Berno Tanner; L Möller; R Meinert; Bernd Kaina
Activity of O(6)-methylguanine-DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer.
International journal of cancer. Journal international du cancer 1999;84(4):388-95.
1999: Sabine Grösch; Bernd Kaina
Transcriptional activation of apurinic/apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREB.
Biochemical and biophysical research communications 1999;261(3):859-63.
1999: Gerhard Fritz; I Just; Bernd Kaina
Rho GTPases are over-expressed in human tumors.
International journal of cancer. Journal international du cancer 1999;81(5):682-7.
1999: T Grombacher; Maja T Tomicic; M Digweed; Bernd Kaina
Overexpression of cDNA encoding FANCC, SPHAR, MPG, SNM1 or HA 3611 does not render CHO cells more resistant to DNA crosslinking agents.
Anticancer research 1999;19(3A):1729-35.
1999: Gerhard Fritz; R Gnad; Bernd Kaina
Cell and tissue-type specific expression of Ras-related GTPase RhoB.
Anticancer research 1999;19(3A):1681-8.
1999: Kirsten Ochs; Robert W Sobol; S H Wilson; Bernd Kaina
Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage.
Cancer research 1999;59(7):1544-51.
1999: Hermann Lage; Markus Christmann; M A Kern; Manfred Dietel; M Pick; Bernd Kaina; Dirk Schadendorf
Expression of DNA repair proteins hMSH2, hMSH6, hMLH1, O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in melanoma cells with acquired drug resistance.
International journal of cancer. Journal international du cancer 1999;80(5):744-50.
1999: Gerhard Fritz; Bernd Kaina
Activation of c-Jun N-terminal kinase 1 by UV irradiation is inhibited by wortmannin without affecting c-iun expression.
Molecular and cellular biology 1999;19(3):1768-74.
1999: Gerhard Fritz; Bernd Kaina
Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1.
Oncogene 1999;18(4):1033-40.
1998: Sabine Grösch; Gerhard Fritz; Bernd Kaina
Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation.
Cancer research 1998;58(19):4410-6.
1998: Bernd Kaina; Gerhard Fritz; Kirsten Ochs; S Haas; T Grombacher; J Dosch; Markus Christmann; Per Lund; Cornelia Gregel; K Becker
Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, thresholds and defense mechanisms.
Mutation research 1998;405(2):179-91.
1998: Jürgen Mattern; Uta Eichhorn; Bernd Kaina; Manfred Volm
O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts.
International journal of cancer. Journal international du cancer 1998;77(6):919-22.
1998: T Grombacher; Uta Eichhorn; Bernd Kaina
p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents.
Oncogene 1998;17(7):845-51.
1998: Bernd Kaina
Critical steps in alkylation-induced aberration formation.
Mutation research 1998;404(1-2):119-24.
1998: J Dosch; Markus Christmann; Bernd Kaina
Mismatch G-T binding activity and MSH2 expression is quantitatively related to sensitivity of cells to methylating agents.
Carcinogenesis 1998;19(4):567-73.
1997: Gerhard Fritz; Bernd Kaina
rhoB encoding a UV-inducible Ras-related small GTP-binding protein is regulated by GTPases of the Rho family and independent of JNK, ERK, and p38 MAP kinase.
The Journal of biological chemistry 1997;272(49):30637-44.
1997: Bernd Kaina; A Ziouta; Kirsten Ochs; T Coquerelle
Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models.
Mutation research 1997;381(2):227-41.
1997: K Becker; Cornelia Gregel; Bernd Kaina
The DNA repair protein O6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineoplastic chloroethylnitrosourea.
Cancer research 1997;57(16):3335-8.
1997: Bernd Kaina; S Haas; H Kappes
A general role for c-Fos in cellular protection against DNA-damaging carcinogens and cytostatic drugs.
Cancer research 1997;57(13):2721-31.
1997: Berno Tanner; Jan G Hengstler; B Dietrich; M Henrich; P Steinberg; Wolfgang Weikel; R Meinert; Bernd Kaina; Franz Oesch; Paul Georg Knapstein
Glutathione, glutathione S-transferase alpha and pi, and aldehyde dehydrogenase content in relationship to drug resistance in ovarian cancer.
Gynecologic oncology 1997;65(1):54-62.
1997: Maja T Tomicic; E Eschbach; Bernd Kaina
Expression of yeast but not human apurinic/apyrimidinic endonuclease renders Chinese hamster cells more resistant to DNA damaging agents.
Mutation research 1997;383(2):155-65.
1997: Gerhard Fritz; Jan G Hengstler; Bernd Kaina
High-dose selection with mafosfamide results in sensitivity to DNA cross-linking agents: characterization of hypersensitive cell lines.
Cancer research 1997;57(3):454-60.
1996: J Dosch; Bernd Kaina
Induction of c-fos, c-jun, junB and junD mRNA and AP-1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and its relationship to cell death, mutation induction and chromosomal instability.
Oncogene 1996;13(9):1927-35.
1996: T Grombacher; Sankar Mitra; Bernd Kaina
Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes.
Carcinogenesis 1996;17(11):2329-36.
1996: K Becker; J Dosch; Cornelia Gregel; B A Martin; Bernd Kaina
Targeted expression of human O(6)-methylguanine-DNA methyltransferase (MGMT) in transgenic mice protects against tumor initiation in two-stage skin carcinogenesis.
Cancer research 1996;56(14):3244-9.
1996: T Grombacher; Bernd Kaina
Isolation and analysis of inducibility of the rat N-methylpurine-DNA glycosylase promoter.
DNA and cell biology 1996;15(7):581-8.
1996: I Preuss; R Thust; Bernd Kaina
Protective effect of O6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs.
International journal of cancer. Journal international du cancer 1996;65(4):506-12.
1996: I Preuss; S Haas; Uta Eichhorn; I Eberhagen; Manfred Kaufmann; T Beck; Robert Eibl; Peter Dall; Thomas Bauknecht; Jan G Hengstler; B M Wittig; W Dippold; Bernd Kaina
Activity of the DNA repair protein O6-methylguanine-DNA methyltransferase in human tumor and corresponding normal tissue.
Cancer detection and prevention 1996;20(2):130-6.
1996: Lorenzo Citti; L Boldrini; I Preuss; Bernd Kaina; L Mariani; Giuseppe Rainaldi
Targeting of O6-methylguanine-DNA methyltransferase (MGMT) activity by antimessenger oligonucleotide sensitizes CHO/Mex+ transfected cells to mitozolomide.
Carcinogenesis 1996;17(1):25-9.
1995: Gerhard Fritz; Bernd Kaina; Klaus Aktories
The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments.
The Journal of biological chemistry 1995;270(42):25172-7.
1995: I Preuss; I Eberhagen; S Haas; Robert Eibl; Manfred Kaufmann; G von Minckwitz; Bernd Kaina
O6-methylguanine-DNA methyltransferase activity in breast and brain tumors.
International journal of cancer. Journal international du cancer 1995;61(3):321-6.
1995: S Haas; Bernd Kaina
c-Fos is involved in the cellular defence against the genotoxic effect of UV radiation.
Carcinogenesis 1995;16(5):985-91.
1995: I Eberhagen; M Bankmann; Bernd Kaina
Detection of O6-methylguanine-DNA methyltransferase-expression in human tumors by means of in situ hybridization.
Anticancer research 1995;15(3):761-7.
1995: T Grombacher; Bernd Kaina
Constitutive expression and inducibility of O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in rat liver cells exhibiting different status of differentiation.
Biochimica et biophysica acta 1995;1270(1):63-72.
1995: T Coquerelle; J Dosch; Bernd Kaina
Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents--a case of imbalanced DNA repair.
Mutation research 1995;336(1):9-17.
1994: Gerhard Fritz; Bernhard Auer; Bernd Kaina
Effect of transfection of human poly(ADP-ribose)polymerase in Chinese hamster cells on mutagen resistance.
Mutation research 1994;308(2):127-33.
1993: Gerhard Fritz; J Dosch; H W Thielmann; Bernd Kaina
Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.
The Journal of biological chemistry 1993;268(28):21102-12.
1993: S van den Berg; HJ Rahmsdorf; Peter Herrlich; Bernd Kaina
Overexpression of c-fos increases recombination frequency in human osteosarcoma cells.
Carcinogenesis 1993;14(5):925-8.
1993: Sankar Mitra; Bernd Kaina
Regulation of repair of alkylation damage in mammalian genomes.
Progress in nucleic acid research and molecular biology 1993;44():109-42.
1993: Bernd Kaina; Gerhard Fritz; T Coquerelle
Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines.
Environmental and molecular mutagenesis 1993;22(4):283-92.
1992: Gerhard Fritz; Bernd Kaina
Stress factors affecting expression of O6-methylguanine-DNA methyltransferase mRNA in rat hepatoma cells.
Biochimica et biophysica acta 1992;1171(1):35-40.
1992: G Ibeanu; B Hartenstein; W C Dunn; L Y Chang; E Hofmann; T Coquerelle; Sankar Mitra; Bernd Kaina
Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells.
Carcinogenesis 1992;13(11):1989-95.
1992: Gerhard Fritz; Bernd Kaina
Genomic differences between O6-methylguanine-DNA methyltransferase proficient (Mex+) and deficient (Mex-) cell lines: possible role of genetic and epigenetic changes in conversion of Mex+ into Mex-.
Biochemical and biophysical research communications 1992;183(3):1184-90.
1991: Bernd Kaina; Gerhard Fritz; Sankar Mitra; T Coquerelle
Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents.
Carcinogenesis 1991;12(10):1857-67.
1991: Gerhard Fritz; K Tano; S Mitra; Bernd Kaina
Inducibility of the DNA repair gene encoding O6-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments.
Molecular and cellular biology 1991;11(9):4660-8.
1991: Bernd Kaina; Gerhard Fritz; T Coquerelle
Identification of human genes involved in repair and tolerance of DNA damage.
Radiation and environmental biophysics 1991;30(1):1-19.
1991: S van den Berg; Bernd Kaina; HJ Rahmsdorf; Helmut Ponta; Peter Herrlich
Involvement of fos in spontaneous and ultraviolet light-induced genetic changes.
Molecular carcinogenesis 1991;4(6):460-6.
1990: Gerhard Fritz; H J Rahmsdorf; Bernd Kaina
Complementation of N-hydroxyethyl-N-chloroethylnitrosourea hypersensitivity of Mex- cells by microinjection of mRNA from Mex+ cells.
Mutation research 1990;244(1):49-53.
1990: Bernd Kaina; H Lohrer; Michael Karin; Peter Herrlich
Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2710-4.
1990: Bernd Kaina; A A van Zeeland; A de Groot; A T Natarajan
DNA repair and chromosomal stability in the alkylating agent-hypersensitive Chinese hamster cell line 27-1.
Mutation research 1990;243(3):219-24.
1989: S Mai; B Stein; S van den Berg; Bernd Kaina; C Lücke-Huhle; Helmut Ponta; HJ Rahmsdorf; M Kraemer; S Gebel; Peter Herrlich
Mechanisms of the ultraviolet light response in mammalian cells.
Journal of cell science 1989;94 ( Pt 4)():609-15.
1989: Gerhard Fürstenberger; B Schurich; Bernd Kaina; R T Petrusevska; Norbert E Fusenig; Friedrich Marks
Tumor induction in initiated mouse skin by phorbol esters and methyl methanesulfonate: correlation between chromosomal damage and conversion ('stage I of tumor promotion') in vivo.
Carcinogenesis 1989;10(4):749-52.
1987: Bernd Kaina; A A Van Zeeland; C Backendorf; H W Thielmann; P Van de Putte
Transfer of human genes conferring resistance to methylating mutagens, but not to UV irradiation and cross-linking agents, into Chinese hamster ovary cells.
Molecular and cellular biology 1987;7(5):2024-30.
1983: R Thust; J Mendel; Bernd Kaina; R Braun
Genetic and cytogenetic effects of 1,3-dimethyl-3-phenyl-1-nitrosourea in Salmonella typhimurium and Chinese hamster V79 cells.
Carcinogenesis 1983;4(4):409-13.