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Tsuneyasu Kaisho

Research Profile

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Chemicals & Drugs

Anatomy

Dendritic Cells

Physiology

Signal Transduction

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Kanako Shimizu; Jun Shinga; Miki Asakura; Taichi Ezaki; Katsuaki Hoshino; Tsuneyasu Kaisho; Shuji Kitahara; Yusuke Sato; Stephen P Schoenberger; Shin-Ichiro Fujii
Invariant NKT Cells Induce Plasmacytoid Dendritic Cell (DC) Cross-Talk with Conventional DCs for Efficient Memory CD8+ T Cell Induction.
Atsushi Okuma; Masao Ono; Tomoyuki Ohba; Setsuya Aiba; Shizuo Akira; Sawako Fukushi; Katsuaki Hoshino; Tsuneyasu Kaisho; Tatsushi Muta
Enhanced apoptosis by disruption of the STAT3-IκB-ζ signaling pathway in epithelial cells induces Sjögren's syndrome-like autoimmune disease.
Tsuneyasu Kaisho
Pathogen sensors and chemokine receptors in dendritic cell subsets.

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2013: Kanako Shimizu; Jun Shinga; Miki Asakura; Taichi Ezaki; Katsuaki Hoshino; Tsuneyasu Kaisho; Shuji Kitahara; Yusuke Sato; Stephen P Schoenberger; Shin-Ichiro Fujii
Invariant NKT Cells Induce Plasmacytoid Dendritic Cell (DC) Cross-Talk with Conventional DCs for Efficient Memory CD8+ T Cell Induction.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(11):5609-19.
2013: Atsushi Okuma; Masao Ono; Tomoyuki Ohba; Setsuya Aiba; Shizuo Akira; Sawako Fukushi; Katsuaki Hoshino; Tsuneyasu Kaisho; Tatsushi Muta
Enhanced apoptosis by disruption of the STAT3-IκB-ζ signaling pathway in epithelial cells induces Sjögren's syndrome-like autoimmune disease.
Immunity 2013;38(3):450-60.
2012: Tsuneyasu Kaisho
Pathogen sensors and chemokine receptors in dendritic cell subsets.
Vaccine 2012;30(52):7652-7.
2012: Izumi Sasaki; Katsuaki Sato; Masanaka Sugiyama; Takahiro Sugiyama; Tadaki Suzuki; Takashi Tanaka; Noriko Toyama-Sorimachi; Chihiro Yamazaki; Takahiro Yano; Akira Ainai; Yuri Fukuda; Hideki Hasegawa; Hiroaki Hemmi; Katsuaki Hoshino; Akihiko Iizuka; Hiroshi Kohara; Takashi Nagasawa; Tomokazu Ohta; Masuyoshi Saito; Tsuneyasu Kaisho
Spi-B is critical for plasmacytoid dendritic cell function and development.
Blood 2012;120(24):4733-43.
2012: Akemi Kosaka; Satoshi Ohashi; Ami Sato; Toshiya Toda; Yayoi Gotoh; Tsuneyasu Kaisho; Hiroko Tsutsui; Huimin Yan; Noriko M Tsuji
Lactococcus lactis subsp. cremoris FC triggers IFN-γ production from NK and T cells via IL-12 and IL-18.
International immunopharmacology 2012;14(4):729-33.
2012: Tomohiro Kurosaki; Takashi Saito; Kiyoshi Takeda; Atsushi Kumanogoh; Tsuneyasu Kaisho
Dynamism of immune reactions and regulation.
International immunology 2012;24(8):473-5.
2012: Takashi Kanaya; Tatsuro Katsuno; Yuuki Kitahara; Kathryn A Knoop; Nachiket Kumar; Stephen J McSorley; Kumiko Nakai; Shinji Fukuda; Koji Hase; Hiroaki Hemmi; Katsuaki Hoshino; Toshi Jinnohara; Tsuneyasu Kaisho; Ayako Sakamoto; Izumi Sasaki; Mayuko Sato; Daisuke Takahashi; Kiminori Toyooka; Ifor R Williams; Osamu Yokosuka; Hiroshi Ohno
The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.
Nature immunology 2012;13(8):729-36.
2012: Shusaku Mizukami; Masato Tanaka; Tsuneyasu Kaisho; Chiaki Kajiwara; Heiichiro Udono
Differential MyD88/IRAK4 requirements for cross-priming and tumor rejection induced by heat shock protein 70-model antigen fusion protein.
Cancer science 2012;103(5):851-9.
2012: Hiroaki Hemmi; Christopher Fiorese; Tsuneyasu Kaisho; Ashira Lubkin; Ines Matos; Masaki Noda; Ralph M Steinman; Koji Suda; Bei Wang; Neeha Zaidi; Lori Zbytnuik; Kenneth Zhang; Juliana Idoyaga
Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(3):1147-55.
2011: Tsuneyasu Kaisho
[Molecular mechanisms for dendritic cell subset functions].
Arerugī = [Allergy] 2011;60(5):559-65.
2010: Tsuneyasu Kaisho
Molecular mechanisms for plasmacytoid dendritic cell function and development.
Vaccine 2010;28(50):8046-7.
2010: Chihiro Yamazaki; Rie Miyamoto; Katsuaki Hoshino; Yuri Fukuda; Izumi Sasaki; Masuyoshi Saito; Hironori Ishiguchi; Takahiro Yano; Takahiro Sugiyama; Hiroaki Hemmi; Takashi Tanaka; Eri Hamada; Takeshi Hirashima; Ryuichi Amakawa; Shirou Fukuhara; Shosaku Nomura; Tomoki Ito; Tsuneyasu Kaisho
Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice.
Biochemical and biophysical research communications 2010;397(4):756-61.
2010: Hideki Amuro; Tomoki Ito; Rie Miyamoto; Hiroyuki Sugimoto; Yoshitaro Torii; Yonsu Son; Naoto Nakamichi; Chihiro Yamazaki; Katsuaki Hoshino; Tsuneyasu Kaisho; Yoshio Ozaki; Muneo Inaba; Ryuichi Amakawa; Shirou Fukuhara
Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, function as inhibitors of cellular and molecular components involved in type I interferon production.
Arthritis and rheumatism 2010;62(7):2073-85.
2010: Kazuhito Gotoh; Yoshihiko Tanaka; Akihiko Nishikimi; Risa Nakamura; Hisakata Yamada; Naoyoshi Maeda; Takahiro Ishikawa; Katsuaki Hoshino; Takehito Uruno; Qinhong Cao; Sadayuki Higashi; Yasushi Kawaguchi; Munechika Enjoji; Ryoichi Takayanagi; Tsuneyasu Kaisho; Yasunobu Yoshikai; Yoshinori Fukui
Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.
The Journal of experimental medicine 2010;207(4):721-30.
2010: Katsuaki Hoshino; Izumi Sasaki; Takahiro Sugiyama; Takahiro Yano; Chihiro Yamazaki; Teruhito Yasui; Hitoshi Kikutani; Tsuneyasu Kaisho
Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3341-5.
2010: Rie Miyamoto; Tomoki Ito; Shosaku Nomura; Ryuichi Amakawa; Hideki Amuro; Yuichi Katashiba; Makoto Ogata; Naoko Murakami; Keiko Shimamoto; Chihiro Yamazaki; Katsuaki Hoshino; Tsuneyasu Kaisho; Shirou Fukuhara
Inhibitor of IkappaB kinase activity, BAY 11-7082, interferes with interferon regulatory factor 7 nuclear translocation and type I interferon production by plasmacytoid dendritic cells.
Arthritis research & therapy 2010;12(3):R87.
2010: Tsuneyasu Kaisho
[Features and molecular mechanisms of nucleic acid adjuvants].
Arerugī = [Allergy] 2010;59(1):14-9.
2010: Tomokazu Matsuda; Yoshiaki Kido; Shun-ichiro Asahara; Tsuneyasu Kaisho; Takashi Tanaka; Naoko Hashimoto; Yutaka Shigeyama; Akihiko Takeda; T Inoue; Yuki Shibutani; Maki Koyanagi; Tetsuya Hosooka; Michihiro Matsumoto; Hiroshi Inoue; Tohru Uchida; Masato Koike; Yasuo Uchiyama; Shizuo Akira; Masato Kasuga
Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice.
The Journal of clinical investigation 2010;120(1):115-26.
2009: Takahiro Nagatake; Satoshi Fukuyama; Dong-Young Kim; Kaoru Goda; Osamu Igarashi; Shintaro Sato; Tomonori Nochi; Hiroshi Sagara; Yoshifumi Yokota; Anton M Jetten; Tsuneyasu Kaisho; Shizuo Akira; Hitomi Mimuro; Chihiro Sasakawa; Yoshinori Fukui; Kohtaro Fujihashi; Taishin Akiyama; Jun-Ichiro Inoue; Josef M Penninger; Jun Kunisawa; Hiroshi Kiyono
Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
The Journal of experimental medicine 2009;206(11):2351-64.
2009: Tsuneyasu Kaisho; Kiyoshi Takeda
The study of innate immunity in Japan: a historical perspective.
International immunology 2009;21(4):313-6.
2009: Yumiko Tsukamoto; Yoshinori Nagai; Ai Kariyone; Takuma Shibata; Tsuneyasu Kaisho; Shizuo Akira; Kensuke Miyake; Kiyoshi Takatsu
Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production.
Molecular immunology 2009;46(7):1278-88.
2009: Takashi Kobayashi; Tae Soo Kim; Anand Jacob; Matthew C Walsh; Yuho Kadono; Ezequiel Fuentes-Pananá; Tomoko Yoshioka; Akihiko Yoshimura; Masahiro Yamamoto; Tsuneyasu Kaisho; Shizuo Akira; John G Monroe; Yongwon Choi
TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses.
PloS one 2009;4(3):e4736.
2008: Tsuneyasu Kaisho; Hermann Wagner
Host-pathogen interactions.
Current opinion in immunology 2008;20(4):369-70.
2008: Katsuaki Hoshino; Tsuneyasu Kaisho
Nucleic acid sensing Toll-like receptors in dendritic cells.
Current opinion in immunology 2008;20(4):408-13.
2008: Tsuneyasu Kaisho; Takashi Tanaka
Turning NF-kappaB and IRFs on and off in DC.
Trends in immunology 2008;29(7):329-36.
2008: Hiroshi Watarai; Etsuko Sekine; Sayo Inoue; Ryusuke Nakagawa; Tsuneyasu Kaisho; Masaru Taniguchi
PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):2993-8.
2008: Hiromichi Taneichi; Hirokazu Kanegane; Mostafa Sira; Takeshi Futatani; Kazunaga Agematsu; Masahiro Sako; Hideo Kaneko; Naomi Kondo; Tsuneyasu Kaisho; Toshio Miyawaki
Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia.
Clinical immunology (Orlando, Fla.) 2008;126(2):148-54.
2008: Tsuneyasu Kaisho
Type I interferon production by nucleic acid-stimulated dendritic cells.
Frontiers in bioscience : a journal and virtual library 2008;13():6034-42.
2008: Takahiro Sugiyama; Katsuaki Hoshino; Masuyoshi Saito; Takahiro Yano; Izumi Sasaki; Chihiro Yamazaki; Shizuo Akira; Tsuneyasu Kaisho
Immunoadjuvant effects of polyadenylic:polyuridylic acids through TLR3 and TLR7.
International immunology 2008;20(1):1-9.
2007: Shintaro Ichikawa; Rei Fujii; Daisuke Fujiwara; Yutaka Komiyama; Tsuneyasu Kaisho; Masahiro Sakaguchi; Yutaka Konishi
MyD88 but not TLR2, 4 or 9 is essential for IL-12 induction by lactic acid bacteria.
Bioscience, biotechnology, and biochemistry 2007;71(12):3026-32.
2007: Satoshi Uematsu; Tsuneyasu Kaisho; Takashi Tanaka; Makoto Matsumoto; Megumi Yamakami; Hiroko Omori; Masahiro Yamamoto; Tamotsu Yoshimori; Shizuo Akira
The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5378-86.
2007: Sushil Kumar Pathak; Sanchita Basu; Kunal Kumar Basu; Anirban Banerjee; Shresh Pathak; Asima Bhattacharyya; Tsuneyasu Kaisho; Manikuntala Kundu; Joyoti Basu
Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages.
Nature immunology 2007;8(6):610-8.
2007: Takashi Tanaka; Michael J Grusby; Tsuneyasu Kaisho
PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit.
Nature immunology 2007;8(6):584-91.
2006: Ranmal Samarasinghe; Prafullakumar Tailor; Tomohiko Tamura; Tsuneyasu Kaisho; Shizuo Akira; Keiko Ozato
Induction of an anti-inflammatory cytokine, IL-10, in dendritic cells after toll-like receptor signaling.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2006;26(12):893-900.
2006: Seon-Ah Ha; Masayuki Tsuji; Keiichiro Suzuki; Bob Meek; Nobutaka Yasuda; Tsuneyasu Kaisho; Sidonia Fagarasan
Regulation of B1 cell migration by signals through Toll-like receptors.
The Journal of experimental medicine 2006;203(11):2541-50.
2006: Satoshi Fukuyama; Tsuyoshi Nagatake; Dong-Young Kim; Kaoru Takamura; Eun Jeong Park; Tsuneyasu Kaisho; Norimitsu Tanaka; Yuichi Kurono; Hiroshi Kiyono
Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4276-80.
2006: Hokuto Kamon; Takaya Kawabe; Hidemitsu Kitamura; Jihye Lee; Daisuke Kamimura; Tsuneyasu Kaisho; Shizuo Akira; Akihiro Iwamatsu; Hisashi Koga; Masaaki Murakami; Toshio Hirano
TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation.
The EMBO journal 2006;25(17):4108-19.
2006: Hidemitsu Kitamura; Hideyuki Morikawa; Hokuto Kamon; Megumi Iguchi; Shintaro Hojyo; Toshiyuki Fukada; Susumu Yamashita; Tsuneyasu Kaisho; Shizuo Akira; Masaaki Murakami; Toshio Hirano
Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function.
Nature immunology 2006;7(9):971-7.
2006: Tsuneyasu Kaisho; Shizuo Akira
Toll-like receptor function and signaling.
The Journal of allergy and clinical immunology 2006;117(5):979-87; quiz 988.
2006: Katsuaki Hoshino; Takahiro Sugiyama; Mitsuru Matsumoto; Takashi Tanaka; Masuyoshi Saito; Hiroaki Hemmi; Osamu Ohara; Shizuo Akira; Tsuneyasu Kaisho
IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9.
Nature 2006;440(7086):949-53.
2006: Dan Kinoshita; Fumiko Hirota; Tsuneyasu Kaisho; Michiyuki Kasai; Keisuke Izumi; Yoshimi Bando; Yasuhiro Mouri; Akemi Matsushima; Shino Niki; Hongwei Han; Kiyotaka Oshikawa; Noriyuki Kuroda; Masahiko Maegawa; Minoru Irahara; Kiyoshi Takeda; Shizuo Akira; Mitsuru Matsumoto
Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):3995-4002.
2005: Naotoshi Kanemitsu; Yukihiko Ebisuno; Toshiyuki Tanaka; Kazuhiro Otani; Haruko Hayasaka; Tsuneyasu Kaisho; Shizuo Akira; Koko Katagiri; Tatsuo Kinashi; Naoya Fujita; Takashi Tsuruo; Masayuki Miyasaka
CXCL13 is an arrest chemokine for B cells in high endothelial venules.
Blood 2005;106(8):2613-8.
2005: Yoshinori Nagai; Toshihiko Kobayashi; Yuji Motoi; Kohtaroh Ishiguro; Sachiko Akashi; Shin-ichiroh Saitoh; Yutaka Kusumoto; Tsuneyasu Kaisho; Shizuo Akira; Mitsuru Matsumoto; Kiyoshi Takatsu; Kensuke Miyake
The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7043-9.
2005: Takahiro Sugiyama; Tsuneyasu Kaisho
[Biological function of Toll-like receptors].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 4():97-101.
2005: Takahiro Sugiyama; Mayda Gursel; Fumihiko Takeshita; Cevayir Coban; Jacqueline Conover; Tsuneyasu Kaisho; Shizuo Akira; Dennis M Klinman; Ken J Ishii
CpG RNA: identification of novel single-stranded RNA that stimulates human CD14+CD11c+ monocytes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2273-9.
2004: Tsuneyasu Kaisho; Shizuo Akira
Pleiotropic function of Toll-like receptors.
Microbes and infection / Institut Pasteur 2004;6(15):1388-94.
2004: Masahiro Yamamoto; Soh Yamazaki; Satoshi Uematsu; Shintaro Sato; Hiroaki Hemmi; Katsuaki Hoshino; Tsuneyasu Kaisho; Hirotaka Kuwata; Osamu Takeuchi; Koichiro Takeshige; Tatsuya Saitoh; Shoji Yamaoka; Naoki Yamamoto; Shunsuke Yamamoto; Tatsushi Muta; Kiyoshi Takeda; Shizuo Akira
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.
Nature 2004;430(6996):218-22.
2004: Noriko Okazaki; Reiko F-Kikuno; Reiko Ohara; Susumu Inamoto; Haruhiko Koseki; Shuichi Hiraoka; Yumiko Saga; Susumu Seino; Motoi Nishimura; Tsuneyasu Kaisho; Katsuaki Hoshino; Hiroshi Kitamura; Takahiro Nagase; Osamu Ohara; Hisashi Koga
Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
DNA research : an international journal for rapid publication of reports on genes and genomes 2004;11(3):205-18.
2004: Hiroaki Hemmi; Osamu Takeuchi; Shintaro Sato; Masahiro Yamamoto; Tsuneyasu Kaisho; Hideki Sanjo; Taro Kawai; Katsuaki Hoshino; Kiyoshi Takeda; Shizuo Akira
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.
The Journal of experimental medicine 2004;199(12):1641-50.
2004: Sandra S Diebold; Tsuneyasu Kaisho; Hiroaki Hemmi; Shizuo Akira; Caetano Reis e Sousa
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.
Science (New York, N.Y.) 2004;303(5663):1529-31.
2004: Masahide Yamada; Kenji Oritani; Tsuneyasu Kaisho; Jun Ishikawa; Hitoshi Yoshida; Ichiro Takahashi; Shinichirou Kawamoto; Naoko Ishida; Hidetoshi Ujiie; Hiroaki Masaie; Marina Botto; Yoshiaki Tomiyama; Yuji Matsuzawa
Complement C1q regulates LPS-induced cytokine production in bone marrow-derived dendritic cells.
European journal of immunology 2004;34(1):221-30.
2003: Tsuneyasu Kaisho; Shizuo Akira
Regulation of dendritic cell function through toll-like receptors.
Current molecular medicine 2003;3(8):759-71.
2003: Hirotaka Kuwata; Yasuyuki Watanabe; Hiroyuki Miyoshi; Masahiro Yamamoto; Tsuneyasu Kaisho; Kiyoshi Takeda; Shizuo Akira
IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages.
Blood 2003;102(12):4123-9.
2003: Masahiro Yamamoto; Shintaro Sato; Hiroaki Hemmi; Satoshi Uematsu; Katsuaki Hoshino; Tsuneyasu Kaisho; Osamu Takeuchi; Kiyoshi Takeda; Shizuo Akira
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.
Nature immunology 2003;4(11):1144-50.
2003: Kenya Honda; Shinya Sakaguchi; Chigusa Nakajima; Ai Watanabe; Hideyuki Yanai; Misako Matsumoto; Toshiaki Ohteki; Tsuneyasu Kaisho; Akinori Takaoka; Shizuo Akira; Tsukasa Seya; Tadatsugu Taniguchi
Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10872-7.
2003: Yukihiko Ebisuno; Toshiyuki Tanaka; Naotoshi Kanemitsu; Hidenobu Kanda; Kazuhito Yamaguchi; Tsuneyasu Kaisho; Shizuo Akira; Masayuki Miyasaka
Cutting edge: the B cell chemokine CXC chemokine ligand 13/B lymphocyte chemoattractant is expressed in the high endothelial venules of lymph nodes and Peyer's patches and affects B cell trafficking across high endothelial venules.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1642-6.
2003: Tsuneyasu Kaisho; Shizuo Akira
[Host defence mechanisms against infections: Innate immunity and adaptive immunity].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2003;92(8):1546-51.
2003: Masahiro Yamamoto; Shintaro Sato; Hiroaki Hemmi; Katsuaki Hoshino; Tsuneyasu Kaisho; Hideki Sanjo; Osamu Takeuchi; Masanaka Sugiyama; Masaru Okabe; Kiyoshi Takeda; Shizuo Akira
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
Science (New York, N.Y.) 2003;301(5633):640-3.
2003: Tsuneyasu Kaisho; Shizuo Akira
Regulation of dendritic cell function through Toll-like receptors.
Current molecular medicine 2003;3(4):373-85.
2003: Alexander D Edwards; Sandra S Diebold; Emma M C Slack; Hideyuki Tomizawa; Hiroaki Hemmi; Tsuneyasu Kaisho; Shizuo Akira; Caetano Reis e Sousa
Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines.
European journal of immunology 2003;33(4):827-33.
2003: Hiroaki Hemmi; Tsuneyasu Kaisho; Kiyoshi Takeda; Shizuo Akira
The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3059-64.
2003: Akira Suzuki; Tsuneyasu Kaisho; Minako Ohishi; Manae Tsukio-Yamaguchi; Takeshi Tsubata; Pandelakis Koni; Takehiko Sasaki; Tak Wah Mak; Toru Nakano
Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.
The Journal of experimental medicine 2003;197(5):657-67.
2003: Kiyoshi Takeda; Tsuneyasu Kaisho; Shizuo Akira
Toll-like receptors.
Annual review of immunology 2003;21():335-76.
2002: Masahiro Yamamoto; Shintaro Sato; Hiroaki Hemmi; Hideki Sanjo; Satoshi Uematsu; Tsuneyasu Kaisho; Katsuaki Hoshino; Osamu Takeuchi; Masaya Kobayashi; Takashi Fujita; Kiyoshi Takeda; Shizuo Akira
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
Nature 2002;420(6913):324-9.
2002: Katsuaki Hoshino; Tsuneyasu Kaisho; Tomio Iwabe; Osamu Takeuchi; Shizuo Akira
Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation.
International immunology 2002;14(10):1225-31.
2002: Alexander D Edwards; Shivanthi P Manickasingham; Roman Spörri; Sandra S Diebold; Oliver Schulz; Alan Sher; Tsuneyasu Kaisho; Shizuo Akira; Caetano Reis e Sousa
Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3652-60.
2002: Tsuneyasu Kaisho; Katsuaki Hoshino; Tomio Iwabe; Osamu Takeuchi; Teruhito Yasui; Shizuo Akira
Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation.
International immunology 2002;14(7):695-700.
2002: Tomoki Ito; Ryuichi Amakawa; Tsuneyasu Kaisho; Hiroaki Hemmi; Kenichirou Tajima; Kazutaka Uehira; Yoshio Ozaki; Hideyuki Tomizawa; Shizuo Akira; Shirou Fukuhara
Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets.
The Journal of experimental medicine 2002;195(11):1507-12.
2002: Teruo Iwasaki; Kunihiro Yamashita; Tohru Tsujimura; Shin-ichiro Kashiwamura; Hiroko Tsutsui; Tsuneyasu Kaisho; Ayako Sugihara; Naoko Yamada; Mutsuko Mukai; Toshiyuki Yoneda; Haruki Okamura; Hitoshi Akedo; Nobuyuki Terada
Interleukin-18 inhibits osteolytic bone metastasis by human lung cancer cells possibly through suppression of osteoclastic bone-resorption in nude mice.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2002;25 Suppl 1():S52-60.
2002: Tsuneyasu Kaisho; Shizuo Akira
Toll-like receptors as adjuvant receptors.
Biochimica et biophysica acta 2002;1589(1):1-13.
2002: Hiroaki Hemmi; Tsuneyasu Kaisho; Osamu Takeuchi; Shintaro Sato; Hideki Sanjo; Katsuaki Hoshino; Takao Horiuchi; Hideyuki Tomizawa; Kiyoshi Takeda; Shizuo Akira
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Nature immunology 2002;3(2):196-200.
2001: Shizuo Akira; Kiyoshi Takeda; Tsuneyasu Kaisho
Toll-like receptors: critical proteins linking innate and acquired immunity.
Nature immunology 2001;2(8):675-80.
2001: Tsuneyasu Kaisho; Shizuo Akira
Toll-like receptors and their signaling mechanism in innate immunity.
Acta odontologica Scandinavica 2001;59(3):124-30.
2001: Akira Suzuki; M T Yamaguchi; Toshiaki Ohteki; T Sasaki; Tsuneyasu Kaisho; Y Kimura; R Yoshida; Andrew Wakeham; T Higuchi; M Fukumoto; T Tsubata; P S Ohashi; Shigeo Koyasu; J M Penninger; Toru Nakano; Tak W Mak
T cell-specific loss of Pten leads to defects in central and peripheral tolerance.
Immunity 2001;14(5):523-34.
2001: Tsuneyasu Kaisho; Osamu Takeuchi; Taro Kawai; Katsuaki Hoshino; Shizuo Akira
Endotoxin-induced maturation of MyD88-deficient dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5688-94.
2001: Akemi Matsushima; Tsuneyasu Kaisho; P D Rennert; Hideki Nakano; K Kurosawa; Daisuke Uchida; K Takeda; Shizuo Akira; Mitsuru Matsumoto
Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I.
The Journal of experimental medicine 2001;193(5):631-6.
2001: Tsuneyasu Kaisho; Kiyoshi Takeda; T Tsujimura; Taro Kawai; F Nomura; N Terada; Shizuo Akira
IkappaB kinase alpha is essential for mature B cell development and function.
The Journal of experimental medicine 2001;193(4):417-26.
2001: Tsuneyasu Kaisho; Shizuo Akira
Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice.
Trends in immunology 2001;22(2):78-83.
2000: Hiroaki Hemmi; Osamu Takeuchi; Taro Kawai; Tsuneyasu Kaisho; Shintaro Sato; Hideki Sanjo; Makoto Matsumoto; Katsuaki Hoshino; H Wagner; Kiyoshi Takeda; Shizuo Akira
A Toll-like receptor recognizes bacterial DNA.
Nature 2000;408(6813):740-5.
2000: Shizuo Akira; Katsuaki Hoshino; Tsuneyasu Kaisho
The role of Toll-like receptors and MyD88 in innate immune responses.
Journal of endotoxin research 2000;6(5):383-7.
2000: Tsuneyasu Kaisho; Shizuo Akira
Critical roles of Toll-like receptors in host defense.
Critical reviews in immunology 2000;20(5):393-405.
1999: Makoto Matsumoto; Toshiyuki Tanaka; Tsuneyasu Kaisho; Hideki Sanjo; Neal G Copeland; D J Gilbert; N A Jenkins; Shizuo Akira
A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):5039-48.
1999: Tohru Tsujimura; Keiko Hashimoto; H Kitayama; Hirokazu Ikeda; Hiroyuki Sugahara; Itaru Matsumura; Tsuneyasu Kaisho; N Terada; Yukihiko Kitamura; Yuzuru Kanakura
Activating mutation in the catalytic domain of c-kit elicits hematopoietic transformation by receptor self-association not at the ligand-induced dimerization site.
Blood 1999;93(4):1319-29.
1996: B O Lee; K Ishihara; K Denno; Y Kobune; M Itoh; O Muraoka; Tsuneyasu Kaisho; T Sasaki; Takahiro Ochi; Toshio Hirano
Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe rheumatoid arthritis.
Arthritis and rheumatism 1996;39(4):629-37.
1996: Yoshitaka Kajimoto; Jun-ichiro Miyagawa; K Ishihara; Y Okuyama; Yoshio Fujitani; M Itoh; H Yoshida; Tsuneyasu Kaisho; T Matsuoka; Hirotaka Watada; Toshiaki Hanafusa; Yoshimitsu Yamasaki; T Kamada; Yuji Matsuzawa; Toshio Hirano
Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity.
Biochemical and biophysical research communications 1996;219(3):941-6.
1995: Jun Ishikawa; Tsuneyasu Kaisho; H Tomizawa; B O Lee; Y Kobune; Johji Inazawa; Kenji Oritani; M Itoh; Takahiro Ochi; K Ishihara
Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth.
Genomics 1995;26(3):527-34.
1994: M Itoh; K Ishihara; H Tomizawa; H Tanaka; Y Kobune; Jun Ishikawa; Tsuneyasu Kaisho; Toshio Hirano
Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase.
Biochemical and biophysical research communications 1994;203(2):1309-17.
1994: Tsuneyasu Kaisho; Jun Ishikawa; Kenji Oritani; Johji Inazawa; H Tomizawa; O Muraoka; Takahiro Ochi; Toshio Hirano
BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5325-9.
1994: T Nagasawa; Tsuneyasu Kaisho; Tadamitsu Kishimoto; Hitoshi Kikutani
Generation and characterization of a monoclonal antibody that inhibits stromal cell-dependent B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2788-97.
1993: O Muraoka; Tsuneyasu Kaisho; M Tanabe; Toshio Hirano
Transcriptional activation of the interleukin-6 gene by HTLV-1 p40tax through an NF-kappa B-like binding site.
Immunology letters 1993;37(2-3):159-65.
1992: Tsuneyasu Kaisho; Kenji Oritani; Jun Ishikawa; M Tanabe; O Muraoka; Takahiro Ochi; Toshio Hirano
Human bone marrow stromal cell lines from myeloma and rheumatoid arthritis that can support murine pre-B cell growth.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(12):4088-95.
1992: Kenji Oritani; Tsuneyasu Kaisho; K Nakajima; Toshio Hirano
Retinoic acid inhibits interleukin-6-induced macrophage differentiation and apoptosis in a murine hematopoietic cell line, Y6.
Blood 1992;80(9):2298-305.
1992: Tsuneyasu Kaisho; T Nagasawa; Tadamitsu Kishimoto; Hitoshi Kikutani
A stromal cell-specific monoclonal antibody augments the stromal cell-dependent B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(4):989-95.
1990: S Inui; Tsuneyasu Kaisho; Hitoshi Kikutani; I Stamenkovic; B Seed; E A Clark; Tadamitsu Kishimoto
Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40.
European journal of immunology 1990;20(8):1747-53.
1986: Hitoshi Kikutani; S Inui; R Sato; E L Barsumian; Hajime Owaki; K Yamasaki; Tsuneyasu Kaisho; N Uchibayashi; R R Hardy; Toshio Hirano
Molecular structure of human lymphocyte receptor for immunoglobulin E.
Cell 1986;47(5):657-65.