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Hiroaki Kajiyama

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Akira Iwase; Hiroaki Kajiyama; Maki Goto; Wakana Hirokawa; Yoshinari Nagatomo; Tatsuo Nakahara; Kiyosumi Shibata; Atsuko Sugita; Fumitaka Kikkawa
Anti-Müllerian hormone as a marker of ovarian reserve in patients with ovarian malignancies who have undergone fertility-preserving surgery and chemotherapy.
Hong Yuan; Kiyosumi Shibata; Nobuhisa Yoshikawa; Eri Asano; Michinari Hamaguchi; Hitoki Hasegawa; Toshinori Hyodo; Satoko Ito; Hiroaki Kajiyama; Fumitaka Kikkawa; Masao Maeda; Takeshi Senga
ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian cancer cells.
Hiroaki Kajiyama; Sawako Fujiwara; Mika Mizuno; Kiyosumi Shibata; Shiro Suzuki; Tomokazu Umezu; Eiko Yamamoto; Fumitaka Kikkawa
Expression of Twist enhances risk of poor oncologic outcome in patients with stage Ib to II cervical carcinoma with lymphovascular space involvement.

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2013: Akira Iwase; Hiroaki Kajiyama; Maki Goto; Wakana Hirokawa; Yoshinari Nagatomo; Tatsuo Nakahara; Kiyosumi Shibata; Atsuko Sugita; Fumitaka Kikkawa
Anti-Müllerian hormone as a marker of ovarian reserve in patients with ovarian malignancies who have undergone fertility-preserving surgery and chemotherapy.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2013;29(4):357-60.
2013: Hong Yuan; Kiyosumi Shibata; Nobuhisa Yoshikawa; Eri Asano; Michinari Hamaguchi; Hitoki Hasegawa; Toshinori Hyodo; Satoko Ito; Hiroaki Kajiyama; Fumitaka Kikkawa; Masao Maeda; Takeshi Senga
ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian cancer cells.
Cancer research 2013;73(5):1581-90.
2013: Hiroaki Kajiyama; Sawako Fujiwara; Mika Mizuno; Kiyosumi Shibata; Shiro Suzuki; Tomokazu Umezu; Eiko Yamamoto; Fumitaka Kikkawa
Expression of Twist enhances risk of poor oncologic outcome in patients with stage Ib to II cervical carcinoma with lymphovascular space involvement.
Human pathology 2013;44(2):181-8.
2012: K Niimi; Kiyosumi Shibata; K Shinjo; T Umezu; Eiko Yamamoto; S Fujiwara; Kazuhiko Ino; Hiroaki Kajiyama; T Kotani; Fumitaka Kikkawa
High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma.
British journal of cancer 2012;107(12):1969-77.
2012: Kotaro Sakai; Kiyosumi Shibata; Shiro Suzuki; Tomokazu Umezu; Hiroaki Kajiyama; Michiyasu Kawai; Mika Mizuno; Tetsuro Nagasaka; Fumitaka Kikkawa
Is there any association between retroperitoneal lymphadenectomy and survival benefit in advanced stage epithelial ovarian carcinoma patients?
The journal of obstetrics and gynaecology research 2012;38(7):1018-23.
2012: Hiroaki Kajiyama; Kiyosumi Shibata; Fumitaka Kikkawa
[Fertility-sparing surgery in epithelial ovarian cancer].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 4():589-93.
2012: Ryuichiro Sekiya; Kiyosumi Shibata; Tomokazu Umezu; Eiko Yamamoto; Sawako Fujiwara; Hiroaki Kajiyama; Mika Mizuno; Tetsuro Nagasaka; Kotaro Sakai; Fumitaka Kikkawa
Expression of CXCR4 indicates poor prognosis in patients with clear cell carcinoma of the ovary.
Human pathology 2012;43(6):904-10.
2012: Dat Tien Trinh; Tomokazu Umezu; Tomoya Hirosawa; Hiroaki Kajiyama; Mika Mizuno; Kiyosumi Shibata; Fumitaka Kikkawa
Diagnostic utility of CD117, CD133, SALL4, OCT4, TCL1 and glypican-3 in malignant germ cell tumors of the ovary.
The journal of obstetrics and gynaecology research 2012;38(5):841-8.
2012: Osamu Maeda; Akihiro Nawa; Kiyosumi Shibata; Koji Tamakoshi; Sawako Fujiwara; Satoyo Hosono; Kazuhiko Ino; Hiroaki Kajiyama; Fumitaka Kikkawa
Spectrin αII and βII tetramers contribute to platinum anticancer drug resistance in ovarian serous adenocarcinoma.
International journal of cancer. Journal international du cancer 2012;130(1):113-21.
2011: Hiroaki Kajiyama; Michiyasu Kawai; Mika Mizuno; Tetsuro Nagasaka; Kiyosumi Shibata; Satoyo Hosono; Fumitaka Kikkawa
Fertility-sparing surgery in patients with clear-cell carcinoma of the ovary: is it possible?
Human reproduction (Oxford, England) 2011;26(12):3297-302.
2011: Makiko Higashi; Satoyo Hosono; Hiroaki Kajiyama; Michiyasu Kawai; Kimio Mizuno; Mika Mizuno; Tetsuro Nagasaka; Toru Nakanishi; Kiyosumi Shibata; Fumitaka Kikkawa
Survival impact of capsule rupture in stage I clear cell carcinoma of the ovary in comparison with other histological types.
Gynecologic oncology 2011;123(3):474-8.
2011: Hiroaki Kajiyama; Michiyasu Kawai; Satoyo Hosono; Katsuji Matsuzawa; Kimio Mizuno; Mika Mizuno; Tetsuro Nagasaka; Akihiro Nawa; Kiyosumi Shibata; Fumitaka Kikkawa
Fertility-sparing surgery in young women with mucinous adenocarcinoma of the ovary.
Gynecologic oncology 2011;122(2):334-8.
2011: Kiyosumi Shibata; Tomokazu Umezu; Maiko Sakurai; Hiroaki Kajiyama; Eiko Yamamoto; Kazuhiko Ino; Akihiro Nawa; Fumitaka Kikkawa
Establishment of cisplatin-resistant ovarian yolk sac tumor cells and investigation of the mechanism of cisplatin resistance using this cell line.
Gynecologic and obstetric investigation 2011;71(2):104-11.
2010: Tomokazu Umezu; Kiyosumi Shibata; Hiroaki Kajiyama; Eiko Yamamoto; Akihiro Nawa; Fumitaka Kikkawa
Glypican-3 expression predicts poor clinical outcome of patients with early-stage clear cell carcinoma of the ovary.
Journal of clinical pathology 2010;63(11):962-6.
2010: Shiro Suzuki; Mikio Terauchi; Tomokazu Umezu; Hiroaki Kajiyama; Kiyosumi Shibata; Akihiro Nawa; Fumitaka Kikkawa
Identification and characterization of cancer stem cells in ovarian yolk sac tumors.
Cancer science 2010;101(10):2179-85.
2010: Tomoko Inaba; Kazuhiko Ino; Hiroaki Kajiyama; Kiyosumi Shibata; Eiko Yamamoto; Shinji Kondo; Tomokazu Umezu; Akihiro Nawa; Osamu Takikawa; Fumitaka Kikkawa
Indoleamine 2,3-dioxygenase expression predicts impaired survival of invasive cervical cancer patients treated with radical hysterectomy.
Gynecologic oncology 2010;117(3):423-8.
2010: Hiroaki Kajiyama; Kiyosumi Shibata; S Suzuki; Kazuhiko Ino; Akihiro Nawa; Michiyasu Kawai; T Nagasaka; Fumitaka Kikkawa
Fertility-sparing surgery in young women with invasive epithelial ovarian cancer.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2010;36(4):404-8.
2010: Sawako Fujiwara; Akihiro Nawa; Toru Nakanishi; Yoshie Shimoyama; Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Shigeo Nakamura; Fumitaka Kikkawa; Yasushi Yatabe
Thyroid transcription factor 1 expression in ovarian carcinomas is an independent prognostic factor.
Human pathology 2010;41(4):560-5.
2010: Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Shigehiko Mizutani; Akihiro Nawa; Fumitaka Kikkawa
The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells.
Cancer science 2010;101(2):347-54.
2010: Daisuke Ishida; Akihiro Nawa; Tadatoshi Tanino; Fumi Goshima; Chen Hong Luo; Masahiro Iwaki; Hiroaki Kajiyama; Kiyosumi Shibata; Eiko Yamamoto; Kazuhiko Ino; Tatsuya Tsurumi; Yukihiro Nishiyama; Fumitaka Kikkawa
Enhanced cytotoxicity with a novel system combining the paclitaxel-2'-ethylcarbonate prodrug and an HSV amplicon with an attenuated replication-competent virus, HF10 as a helper virus.
Cancer letters 2010;288(1):17-27.
2010: Satoyo Hosono; Takakazu Kawase; Keitaro Matsuo; Miki Watanabe; Hiroaki Kajiyama; Kaoru Hirose; Takeshi Suzuki; Kumiko Kidokoro; Hidemi Ito; Toru Nakanishi; Yasushi Yatabe; Nobuyuki Hamajima; Fumitaka Kikkawa; Kazuo Tajima; Hideo Tanaka
HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women.
Journal of epidemiology / Japan Epidemiological Association 2010;20(4):295-301.
2010: Tomokazu Umezu; Kiyosumi Shibata; Maiko Shimaoka; Hiroaki Kajiyama; Eiko Yamamoto; Kazuhiko Ino; Akihiro Nawa; Takeshi Senga; Fumitaka Kikkawa
Gene silencing of glypican-3 in clear cell carcinoma of the ovary renders it more sensitive to the apoptotic agent paclitaxel in vitro and in vivo.
Cancer science 2010;101(1):143-8.
2009: Noriko Takahashi; Eiko Yamamoto; Kazuhiko Ino; Eiji Miyoshi; Tetsuro Nagasaka; Hiroaki Kajiyama; Kiyosumi Shibata; Akihiro Nawa; Fumitaka Kikkawa
High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary.
Oncology reports 2009;22(5):1027-32.
2009: Tomoko Inaba; Kazuhiko Ino; Hiroaki Kajiyama; Eiko Yamamoto; Kiyosumi Shibata; Akihiro Nawa; Tetsuro Nagasaka; Hidetoshi Akimoto; Osamu Takikawa; Fumitaka Kikkawa
Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma.
Gynecologic oncology 2009;115(2):185-92.
2009: Kiyosumi Shibata; Hiroaki Kajiyama; Eiko Yamamoto; Mikio Terauchi; Kazuhiko Ino; Seiji Nomura; Akihiro Nawa; Michiyasu Kawai; Fumitaka Kikkawa
Effectiveness of preoperative concurrent chemoradiation therapy (CCRT) for locally advanced adenocarcinoma of cervix.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2009;35(7):768-72.
2009: Eiko Yamamoto; Kazuhiko Ino; Eiji Miyoshi; Kei-ichiro Inamori; Akihiro Abe; Seiji Sumigama; Akira Iwase; Hiroaki Kajiyama; Kiyosumi Shibata; Akihiro Nawa; Fumitaka Kikkawa
N-acetylglucosaminyltransferase V regulates extravillous trophoblast invasion through glycosylation of alpha5beta1 integrin.
Endocrinology 2009;150(2):990-9.
2009: Yukio Mano; Kiyosumi Shibata; Seiji Sumigama; Hiromi Hayakawa; Kazuhiko Ino; Eiko Yamamoto; Hiroaki Kajiyama; Akihiro Nawa; Fumitaka Kikkawa
Tocilizumab inhibits interleukin-6-mediated matrix metalloproteinase-2 and -9 secretions from human amnion cells in preterm premature rupture of membranes.
Gynecologic and obstetric investigation 2009;68(3):145-53.
2008: Hiroaki Kajiyama; Kiyosumi Shibata; Shiro Suzuki; Kazuhiko Ino; Eiko Yamamoto; Kimio Mizuno; Katsumi Sakakibara; Katsuji Matsuzawa; Akihiro Takeda; Yoshito Kinoshita; Michiyasu Kawai; Tetsuro Nagasaka; Akihiro Nawa; Fumitaka Kikkawa
Is there any possibility of fertility-sparing surgery in patients with clear-cell carcinoma of the ovary?
Gynecologic oncology 2008;111(3):523-6.
2008: Norio Yoshida; Kazuhiko Ino; Yoshiyuki Ishida; Hiroaki Kajiyama; Eiko Yamamoto; Kiyosumi Shibata; Mikio Terauchi; Akihiro Nawa; Hidetoshi Akimoto; Osamu Takikawa; Ken-Ichi Isobe; Fumitaka Kikkawa
Overexpression of indoleamine 2,3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(22):7251-9.
2008: S Suzuki; Hiroaki Kajiyama; K Shibata; Kazuhiko Ino; Akihiro Nawa; K Sakakibara; Katsuji Matsuzawa; A Takeda; Y Kinoshita; Michiyasu Kawai; Tetsuro Nagasaka; Fumitaka Kikkawa
Is there any association between retroperitoneal lymphadenectomy and survival benefit in ovarian clear cell carcinoma patients?
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(7):1284-7.
2008: Kiyosumi Shibata; Hiroaki Kajiyama; Mikio Terauchi; Eiko Yamamoto; Kazuhiko Ino; Akihiro Nawa; Fumitaka Kikkawa
Feasibility and effectiveness of postoperative adjuvant concurrent chemoradiation therapy in Japanese patients with high-risk early-stage cancer of the uterine cervix.
International journal of clinical oncology 2008;13(3):233-8.
2008: Satoyo Hosono; Keitaro Matsuo; Hiroaki Kajiyama; Kaoru Hirose; Takeshi Suzuki; Akio Hiraki; Takakazu Kawase; Kumiko Kidokoro; Toru Nakanishi; Nobuyuki Hamajima; Fumitaka Kikkawa; Kazuo Tajima; Hideo Tanaka
Reduced risk of endometrial cancer from alcohol drinking in Japanese.
Cancer science 2008;99(6):1195-201.
2008: Kazuhiko Ino; Eiko Yamamoto; Kiyosumi Shibata; Hiroaki Kajiyama; Norio Yoshida; Mikio Terauchi; Akihiro Nawa; Tetsuro Nagasaka; Osamu Takikawa; Fumitaka Kikkawa
Inverse correlation between tumoral indoleamine 2,3-dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer: its association with disease progression and survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(8):2310-7.
2008: Tomokazu Umezu; Kiyosumi Shibata; Hiroaki Kajiyama; Mikio Terauchi; Kazuhiko Ino; Akihiro Nawa; Fumitaka Kikkawa
Taxol resistance among the different histological subtypes of ovarian cancer may be associated with the expression of class III beta-tubulin.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2008;27(2):207-12.
2008: Tomokazu Umezu; Hiroaki Kajiyama; Mikio Terauchi; Kiyosumi Shibata; Kazuhiko Ino; Akihiro Nawa; Fumitaka Kikkawa
Long-term outcome and prognostic factors for yolk sac tumor of the ovary.
Nagoya journal of medical science 2008;70(1-2):29-34.
2008: Akihiro Nawa; Tadatoshi Tanino; Chenhong Luo; Masahiro Iwaki; Hiroaki Kajiyama; Kiyosumi Shibata; Eiko Yamamoto; Kazuhiko Ino; Yukihiro Nishiyama; Fumitaka Kikkawa
Gene directed enzyme prodrug therapy for ovarian cancer: could GDEPT become a promising treatment against ovarian cancer?
Anti-cancer agents in medicinal chemistry 2008;8(2):232-9.
2008: Masako Araki-Taguchi; Seiji Nomura; Kazuhiko Ino; Seiji Sumigama; Eiko Yamamoto; Tomomi Kotani-Ito; Hiromi Hayakawa; Hiroaki Kajiyama; Kiyosumi Shibata; Atsuo Itakura; Fumitaka Kikkawa
Angiotensin II mimics the hypoxic effect on regulating trophoblast proliferation and differentiation in human placental explant cultures.
Life sciences 2008;82(1-2):59-67.
2008: Kiyosumi Shibata; Hiroaki Kajiyama; Eiko Yamamoto; Mikio Terauchi; Kazuhiko Ino; Akihiro Nawa; Fumitaka Kikkawa
Establishment and characterization of an ovarian yolk sac tumor cell line reveals possible involvement of Nkx2.5 in tumor development.
Oncology 2008;74(1-2):104-11.
2008: Hirohisa Tsukamoto; Kiyosumi Shibata; Hiroaki Kajiyama; Mikio Terauchi; Akihiro Nawa; Fumitaka Kikkawa
Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer.
BMC cancer 2008;8():74.
2008: K Shibata; Hiroaki Kajiyama; Kazuhiko Ino; Mikio Terauchi; Eiko Yamamoto; Akihiro Nawa; S Nomura; Fumitaka Kikkawa
Twist expression in patients with cervical cancer is associated with poor disease outcome.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(1):81-5.
2008: Hiroaki Kajiyama; Kiyosumi Shibata; Mikio Terauchi; Kazuhiko Ino; Akihiro Nawa; Fumitaka Kikkawa
Involvement of SDF-1alpha/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma.
International journal of cancer. Journal international du cancer 2008;122(1):91-9.
2007: Eiko Yamamoto; Kazuhiko Ino; E Miyoshi; Kiyosumi Shibata; N Takahashi; Hiroaki Kajiyama; Akihiro Nawa; Seiji Nomura; Tetsuro Nagasaka; Fumitaka Kikkawa
Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis.
British journal of cancer 2007;97(11):1538-44.
2007: Hirohisa Tsukamoto; Kiyosumi Shibata; Hiroaki Kajiyama; Mikio Terauchi; Akihiro Nawa; Fumitaka Kikkawa
Irradiation-induced epithelial-mesenchymal transition (EMT) related to invasive potential in endometrial carcinoma cells.
Gynecologic oncology 2007;107(3):500-4.
2007: Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Akihiro Nawa; Shigehiko Mizutani; Fumitaka Kikkawa
Possible involvement of SDF-1alpha/CXCR4-DPPIV axis in TGF-beta1-induced enhancement of migratory potential in human peritoneal mesothelial cells.
Cell and tissue research 2007;330(2):221-9.
2007: Tomokazu Umezu; Hiroaki Kajiyama; Mikio Terauchi; Kiyosumi Shibata; Kazuhiko Ino; Akihiro Nawa; Fumitaka Kikkawa
Establishment of a new cell line of endometrioid carcinoma of the ovary and its chemosensitivity.
Human cell 2007;20(3):71-6.
2007: Hiroaki Kajiyama; Kiyosumi Shibata; Mikio Terauchi; Mamoru Yamashita; Kazuhiko Ino; Akihiro Nawa; Fumitaka Kikkawa
Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells.
International journal of oncology 2007;31(2):277-83.
2007: Mamoru Yamashita; Hiroaki Kajiyama; Mikio Terauchi; Kiyosumi Shibata; Kazuhiko Ino; Akihiro Nawa; Shigehiko Mizutani; Fumitaka Kikkawa
Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo.
International journal of cancer. Journal international du cancer 2007;120(10):2243-50.
2007: Satoyo Hosono; Hiroaki Kajiyama; Mikio Terauchi; Kiyosumi Shibata; Kazuhiko Ino; Akihiro Nawa; Fumitaka Kikkawa
Expression of Twist increases the risk for recurrence and for poor survival in epithelial ovarian carcinoma patients.
British journal of cancer 2007;96(2):314-20.
2007: Mikio Terauchi; Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Akihiro Nawa; Shigehiko Mizutani; Fumitaka Kikkawa
Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells.
BMC cancer 2007;7():140.
2007: Hirohisa Tsukamoto; Kiyosumi Shibata; Hiroaki Kajiyama; Mikio Terauchi; Akihiro Nawa; Fumitaka Kikkawa
Uterine smooth muscle cells increase invasive ability of endometrial carcinoma cells through tumor-stromal interaction.
Clinical & experimental metastasis 2007;24(6):423-9.
2007: Mikio Terauchi; Hiroaki Kajiyama; Mamoru Yamashita; Mikihiko Kato; Hirohisa Tsukamoto; Tomokazu Umezu; Satoyo Hosono; Eiko Yamamoto; Kiyosumi Shibata; Kazuhiko Ino; Akihiro Nawa; Tetsuro Nagasaka; Fumitaka Kikkawa
Possible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinoma.
Clinical & experimental metastasis 2007;24(5):329-39.
2007: Kiyosumi Shibata; Hiroaki Kajiyama; Kazuhiko Ino; Akihiro Nawa; Seiji Nomura; Shigehiko Mizutani; Fumitaka Kikkawa
P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling.
BMC cancer 2007;7():15.
2006: Kazuhiko Ino; N Yoshida; Hiroaki Kajiyama; Kiyosumi Shibata; Eiko Yamamoto; K Kidokoro; N Takahashi; Mikio Terauchi; Akihiro Nawa; Seiji Nomura; Tetsuro Nagasaka; O Takikawa; Fumitaka Kikkawa
Indoleamine 2,3-dioxygenase is a novel prognostic indicator for endometrial cancer.
British journal of cancer 2006;95(11):1555-61.
2006: Hiroaki Kajiyama; Kiyosumi Shibata; Mikio Terauchi; Kazuhiko Ino; Akihiro Nawa; Fumitaka Kikkawa
Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells.
Annals of the New York Academy of Sciences 2006;1086():233-40.
2006: Fumitaka Kikkawa; Akihiro Nawa; Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Seiji Nomura
Clinical characteristics and prognosis of mucinous tumors of the ovary.
Gynecologic oncology 2006;103(1):171-5.
2006: Mika Mizuno; Fumitaka Kikkawa; Kiyosumi Shibata; Hiroaki Kajiyama; Kazuhiko Ino; Michiyasu Kawai; Tetsuro Nagasaka; Seiji Nomura
Long-term follow-up and prognostic factor analysis in clear cell adenocarcinoma of the ovary.
Journal of surgical oncology 2006;94(2):138-43.
2006: Yuji Shimomura; Hisao Ando; Kazunori Furugori; Hiroaki Kajiyama; Miyabi Suzuki; Akira Iwase; Shigehiko Mizutani; Fumitaka Kikkawa
Possible involvement of crosstalk cell-adhesion mechanism by endometrial CD26/dipeptidyl peptidase IV and embryonal fibronectin in human blastocyst implantation.
Molecular human reproduction 2006;12(8):491-5.
2006: S Ishimatsu; Atsuo Itakura; Mayumi Okada; T Kotani; A Iwase; Hiroaki Kajiyama; Kazuhiko Ino; Fumitaka Kikkawa
Angiotensin II augmented migration and invasion of choriocarcinoma cells involves PI3K activation through the AT1 receptor.
Placenta 2006;27(6-7):587-91.
2006: Chihiro Kondo; Kiyosumi Shibata; Mikio Terauchi; Hiroaki Kajiyama; Kazuhiko Ino; Seiji Nomura; Akihiro Nawa; Shigehiko Mizutani; Fumitaka Kikkawa
A novel role for placental leucine aminopeptidase (P-LAP) as a determinant of chemoresistance in endometrial carcinoma cells.
International journal of cancer. Journal international du cancer 2006;118(6):1390-4.
2006: Kazuhiko Ino; Kiyosumi Shibata; Hiroaki Kajiyama; Akihiro Nawa; Seiji Nomura; Fumitaka Kikkawa
Manipulating the angiotensin system--new approaches to the treatment of solid tumours.
Expert opinion on biological therapy 2006;6(3):243-55.
2006: Kazuhiko Ino; Kiyosumi Shibata; Hiroaki Kajiyama; Eiko Yamamoto; Tetsuro Nagasaka; Akihiro Nawa; Seiji Nomura; Fumitaka Kikkawa
Angiotensin II type 1 receptor expression in ovarian cancer and its correlation with tumour angiogenesis and patient survival.
British journal of cancer 2006;94(4):552-60.
2006: Hiroaki Kajiyama; Satoyo Hosono; Mikio Terauchi; Kiyosumi Shibata; Kazuhiko Ino; Eiko Yamamoto; Seiji Nomura; Akihiro Nawa; Fumitaka Kikkawa
Twist expression predicts poor clinical outcome of patients with clear cell carcinoma of the ovary.
Oncology 2006;71(5-6):394-401.
2006: Seiji Nomura; Takayasu Suganuma; Takahiro Suzuki; Tomomi Ito; Hiroaki Kajiyama; Mayumi Okada; Kiyosumi Shibata; Kazuhiko Ino; Fumitaka Kikkawa; Shigehiko Mizutani
Endometrioid adenocarcinoma arising from endometriosis during 2 years of estrogen replacement therapy after total hysterectomy and bilateral salpingo-oophorectomy.
Acta obstetricia et gynecologica Scandinavica 2006;85(8):1019-21.
2006: Fumitaka Kikkawa; Akihiro Nawa; Kazuhiko Ino; Kiyosumi Shibata; Hiroaki Kajiyama; Seiji Nomura
Advances in treatment of epithelial ovarian cancer.
Nagoya journal of medical science 2006;68(1-2):19-26.
2005: Fumitaka Kikkawa; Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Seiji Nomura; Shigehiko Mizutani
Dipeptidyl peptidase IV in tumor progression.
Biochimica et biophysica acta 2005;1751(1):45-51.
2005: M Nishikawa; Atsuo Itakura; Mitsuaki Ito; Mikihito Takeuchi; Yuzo Sato; Hiroaki Kajiyama; Shigehiko Mizutani; Fumitaka Kikkawa
Changes in placental dipeptidyl peptidase IV in preeclampsia with intrauterine growth restriction.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2005;37(7):408-13.
2005: Kiyosumi Shibata; Hiroaki Kajiyama; Yayoi Mizokami; Kazuhiko Ino; Seiji Nomura; Shigehiko Mizutani; Mikio Terauchi; Fumitaka Kikkawa
Placental leucine aminopeptidase (P-LAP) and glucose transporter 4 (GLUT4) expression in benign, borderline, and malignant ovarian epithelia.
Gynecologic oncology 2005;98(1):11-8.
2005: Takayasu Suganuma; Kazuhiko Ino; Kiyosumi Shibata; Hiroaki Kajiyama; Tetsuro Nagasaka; Shigehiko Mizutani; Fumitaka Kikkawa
Functional expression of the angiotensin II type 1 receptor in human ovarian carcinoma cells and its blockade therapy resulting in suppression of tumor invasion, angiogenesis, and peritoneal dissemination.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2686-94.
2005: S Arita; Fumitaka Kikkawa; Hiroaki Kajiyama; Kiyosumi Shibata; M Kawai; K Mizuno; Tetsuro Nagasaka; Kazuhiko Ino; Seiji Nomura
Prognostic importance of vascular endothelial growth factor and its receptors in the uterine sarcoma.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2005;15(2):329-36.
2005: Hiroaki Kajiyama; Kiyosumi Shibata; Mikio Terauchi; Takanori Morita; Kazuhiko Ino; Shigehiko Mizutani; Fumitaka Kikkawa
Neutral endopeptidase 24.11/CD10 suppresses progressive potential in ovarian carcinoma in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(5):1798-808.
2005: Mikio Terauchi; Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Shigehiko Mizutani; Fumitaka Kikkawa
Anti-progressive effect of neutral endopeptidase 24.11 (NEP/CD10) on cervical carcinoma in vitro and in vivo.
Oncology 2005;69(1):52-62.
2005: Kiyosumi Shibata; Fumitaka Kikkawa; Yayoi Mizokami; Hiroaki Kajiyama; Kazuhiko Ino; Seiji Nomura; Shigehiko Mizutani
Possible involvement of adipocyte-derived leucine aminopeptidase via angiotensin II in endometrial carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2005;26(1):9-16.
2004: Kiyosumi Shibata; Fumitaka Kikkawa; Chihiro Kondo; Yayoi Mizokami; Hiroaki Kajiyama; Kazuhiko Ino; Seiji Nomura; Shigehiko Mizutani
Placental leucine aminopeptidase (P-LAP) expression is associated with chemosensitivity in human endometrial carcinoma.
Gynecologic oncology 2004;95(2):307-13.
2004: Kazuhiko Ino; Kiyosumi Shibata; Hiroaki Kajiyama; Fumitaka Kikkawa; Shigehiko Mizutani
Regulatory role of membrane-bound peptidases in the progression of gynecologic malignancies.
Biological chemistry 2004;385(8):683-90.
2004: Seiji Sumigama; Tomomi Ito; Hiroaki Kajiyama; Kiyosumi Shibata; Koji Tamakoshi; Fumitaka Kikkawa; Trevor Williams; Michael A Tainsky; Seiji Nomura; Shigehiko Mizutani
Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha.
Oncogene 2004;23(32):5496-504.
2004: Yayoi Mizokami; Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Fumitaka Kikkawa; Shigehiko Mizutani
Stromal cell-derived factor-1alpha-induced cell proliferation and its possible regulation by CD26/dipeptidyl peptidase IV in endometrial adenocarcinoma.
International journal of cancer. Journal international du cancer 2004;110(5):652-9.
2004: Fumitaka Kikkawa; Mika Mizuno; Kiyosumi Shibata; Hiroaki Kajiyama; Takanori Morita; Kazuhiko Ino; Seiji Nomura; Shigehiko Mizutani
Activation of invasiveness of cervical carcinoma cells by angiotensin II.
American journal of obstetrics and gynecology 2004;190(5):1258-63.
2004: Takayasu Suganuma; Kazuhiko Ino; Kiyosumi Shibata; Seiji Nomura; Hiroaki Kajiyama; Fumitaka Kikkawa; Tsuruoka Nobuo; Shigehiko Mizutani
Regulation of aminopeptidase A expression in cervical carcinoma: role of tumor-stromal interaction and vascular endothelial growth factor.
Laboratory investigation; a journal of technical methods and pathology 2004;84(5):639-48.
2004: Takanori Morita; Kiyosumi Shibata; Fumitaka Kikkawa; Hiroaki Kajiyama; Kazuhiko Ino; Shigehiko Mizutani
Oxytocin inhibits the progression of human ovarian carcinoma cells in vitro and in vivo.
International journal of cancer. Journal international du cancer 2004;109(4):525-32.
2004: Fumitaka Kikkawa; Kiyosumi Shibata; Takahiro Suzuki; Hiroaki Kajiyama; Kazuhiko Ino; Seiji Nomura; Shigehiko Mizutani
Signal pathway involved in increased expression of neutral endopeptidase 24.11 by gonadotropin releasing hormone in choriocarcinoma cells.
Placenta 2004;25(2-3):176-83.
2004: Kiyosumi Shibata; Fumitaka Kikkawa; Yuka Suzuki; Yayoi Mizokami; Hiroaki Kajiyama; Kazuhiko Ino; Seiji Nomura; Tetsuro Nagasaka; Shigehiko Mizutani
Expression of placental leucine aminopeptidase is associated with a poor outcome in endometrial endometrioid adenocarcinoma.
Oncology 2004;66(4):288-95.
2004: Kiyosumi Shibata; Fumitaka Kikkawa; Yuka Suzuki; Mikio Terauchi; Hiroaki Kajiyama; Kazuhiko Ino; Shigehiko Mizutani
Usefulness of preoperative chemoradiation in locally advanced cervical carcinoma.
Gynecologic and obstetric investigation 2004;57(2):93-9.
2003: Yoshiteru Watanabe; Kiyosumi Shibata; Fumitaka Kikkawa; Hiroaki Kajiyama; Kazuhiko Ino; Akira Hattori; Masafumi Tsujimoto; Shigehiko Mizutani
Adipocyte-derived leucine aminopeptidase suppresses angiogenesis in human endometrial carcinoma via renin-angiotensin system.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6497-503.
2003: Kazuhiko Ino; Fumitaka Kikkawa; Takahiro Suzuki; Hiroaki Kajiyama; Kiyosumi Shibata; Seiji Nomura; Atsuo Itakura; Mitsuaki Ito; Tetsuro Nagasaka; Akira Hattori; Masafumi Tsujimoto; Shigehiko Mizutani
Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells.
Laboratory investigation; a journal of technical methods and pathology 2003;83(12):1799-809.
2003: Kiyosumi Shibata; Fumitaka Kikkawa; M Mika; Y Suzuki; Hiroaki Kajiyama; Kazuhiko Ino; Shigehiko Mizutani
Neoadjuvant chemotherapy for FIGO stage III or IV ovarian cancer: Survival benefit and prognostic factors.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2003;13(5):587-92.
2003: Takahiro Suzuki; Kazuhiko Ino; Fumitaka Kikkawa; Kiyosumi Shibata; Hiroaki Kajiyama; Takanori Morita; Tetsuro Nagasaka; Shigehiko Mizutani
Cushing's syndrome due to ovarian serous adenocarcinoma secreting multiple endocrine substances: a case report and immunohistochemical analysis.
Gynecologic oncology 2003;90(3):662-6.
2003: Hideo Kazeto; Seiji Nomura; Norio Ito; Tomomi Ito; Yoshiteru Watanabe; Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Koji Tamakoshi; Akira Hattori; Fumitaka Kikkawa; Tetsuro Nagasaka; Masafumi Tsujimoto; Shigehiko Mizutani
Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer. Association with tumor grade and CA-125.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2003;24(4):203-8.
2003: Kazuhiko Ino; Carlos Uehara; Fumitaka Kikkawa; Hiroaki Kajiyama; Kiyosumi Shibata; Takahiro Suzuki; Ei Ei Khin; Mitsuaki Ito; Mikihito Takeuchi; Atsuo Itakura; Shigehiko Mizutani
Enhancement of aminopeptidase A expression during angiotensin II-induced choriocarcinoma cell proliferation through AT1 receptor involving protein kinase C- and mitogen-activated protein kinase-dependent signaling pathway.
The Journal of clinical endocrinology and metabolism 2003;88(8):3973-82.
2003: Fumitaka Kikkawa; Hiroaki Kajiyama; Kazuhiko Ino; Kiyosumi Shibata; Shigehiko Mizutani
Increased adhesion potency of ovarian carcinoma cells to mesothelial cells by overexpression of dipeptidyl peptidase IV.
International journal of cancer. Journal international du cancer 2003;105(6):779-83.
2003: Hiroaki Kajiyama; Fumitaka Kikkawa; Ei Ei Khin; Kiyosumi Shibata; Kazuhiko Ino; Shigehiko Mizutani
Dipeptidyl peptidase IV overexpression induces up-regulation of E-cadherin and tissue inhibitors of matrix metalloproteinases, resulting in decreased invasive potential in ovarian carcinoma cells.
Cancer research 2003;63(9):2278-83.
2003: Yuka Suzuki; Kiyosumi Shibata; Fumitaka Kikkawa; Hiroaki Kajiyama; Kazuhiko Ino; Seiji Nomura; Masafumi Tsujimoto; Shigehiko Mizutani
Possible role of placental leucine aminopeptidase in the antiproliferative effect of oxytocin in human endometrial adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(4):1528-34.
2003: Ei Ei Khin; Fumitaka Kikkawa; Kazuhiko Ino; Takahiro Suzuki; Kiyosumi Shibata; Hiroaki Kajiyama; Koji Tamakoshi; Shigehiko Mizutani
Neutral endopeptidase/CD10 expression in the stroma of epithelial ovarian carcinoma.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2003;22(2):175-80.
2003: Ei Ei Khin; Fumitaka Kikkawa; Kazuhiko Ino; Hiroaki Kajiyama; Takahiro Suzuki; Kiyosumi Shibata; Koji Tamakoshi; Tetsuro Nagasaka; Shigehiko Mizutani
Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade.
American journal of obstetrics and gynecology 2003;188(3):670-6.
2003: Mika Mizuno; Fumitaka Kikkawa; Kiyosumi Shibata; Hiroaki Kajiyama; Takahiro Suzuki; Kazuhiko Ino; Michiyasu Kawai; Shigehiko Mizutani
Long-term prognosis of stage I ovarian carcinoma. Prognostic importance of intraoperative rupture.
Oncology 2003;65(1):29-36.
2003: Shigehiko Mizutani; Hiroaki Kajiyama; Takahiro Suzuki; Kiyosumi Shibata; Kazuhiko Ino; Fumitaka Kikkawa
Survival time and invasive activity due to dipeptidyl peptidase IV overexpression in ovarian carcinoma.
Advances in experimental medicine and biology 2003;524():253-6.
2003: Fumitaka Kikkawa; Hiroaki Kajiyama; Kazuhiko Ino; Kiyosumi Shibata; Shigehiko Mizutani
Adhesion potency to mesothelial cells by overexpression of dipeptidyl peptidase IV.
Advances in experimental medicine and biology 2003;524():249-52.
2003: Hiroaki Kajiyama; Fumitaka Kikkawa; Kazuhiko Ino; Kiyosumi Shibata; Shigehiko Mizutani
Expression of CD26/dipeptidyl peptidase IV in endometrial adenocarcinoma and its negative correlation with tumor grade.
Advances in experimental medicine and biology 2003;524():245-8.
2002: Fumitaka Kikkawa; Hiroaki Kajiyama; Kazuhiko Ino; Yoshiteru Watanabe; Mitsuaki Ito; Seiji Nomura; Atsuo Itakura; Masafumi Tsujimoto; Shigehiko Mizutani
Possible involvement of placental peptidases that degrade gonadotropin-releasing hormone (GnRH) in the dynamic pattern of placental hCG secretion via GnRH degradation.
Placenta 2002;23(6):483-9.
2002: Takahiro Suzuki; Kazuhiko Ino; Fumitaka Kikkawa; Carlos Uehara; Hiroaki Kajiyama; Kiyosumi Shibata; Shigehiko Mizutani
Neutral endopeptidase/CD10 expression during phorbol ester-induced differentiation of choriocarcinoma cells through the protein kinase C- and extracellular signal-regulated kinase-dependent signalling pathway.
Placenta 2002;23(6):475-82.
2002: Hiroaki Kajiyama; Fumitaka Kikkawa; Takahiro Suzuki; Kiyosumi Shibata; Kazuhiko Ino; Shigehiko Mizutani
Prolonged survival and decreased invasive activity attributable to dipeptidyl peptidase IV overexpression in ovarian carcinoma.
Cancer research 2002;62(10):2753-7.
2002: Fumitaka Kikkawa; Kiyosumi Shibata; Kazuhiko Ino; Seiji Nomura; Hiroaki Kajiyama; Takahiro Suzuki; Michiyasu Kawai; Shigehiko Mizutani
Preoperative findings in non-gynecologic carcinomas metastasizing to the ovaries.
Gynecologic and obstetric investigation 2002;54(4):221-7.
2002: Hiroaki Kajiyama; Fumitaka Kikkawa; Osamu Maeda; Takahiro Suzuki; Kazuhiko Ino; Shigehiko Mizutani
Increased expression of dipeptidyl peptidase IV in human mesothelial cells by malignant ascites from ovarian carcinoma patients.
Oncology 2002;63(2):158-65.
2001: Carlos Uehara; Kazuhiko Ino; Takahiro Suzuki; Hiroaki Kajiyama; Fumitaka Kikkawa; Tetsuro Nagasaka; Shigehiko Mizutani
Upregulation of neutral endopeptidase expression and enzymatic activity during the differentiation of human choriocarcinoma cells.
Placenta 2001;22(6):540-9.