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Hideaki Kakeya

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Chemicals & Drugs

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Aspergillus fumigatus

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Rafael Atillo Espiritu; Hideaki Kakeya; Nobuaki Matsumori; Shigeki Matsunaga; Michio Murata; Shinichi Nishimura; Minoru Yoshida
Interaction between the marine sponge cyclic peptide theonellamide A and sterols in lipid bilayers as viewed by surface plasmon resonance and solid-state (2)H nuclear magnetic resonance.
Yuuki Nagamoto; Akira Hattori; Hideaki Kakeya; Yoshiji Takemoto; Kiyosei Takasu
pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols.
Satsuki Otsuki; Yuki Sakai; Hisae Takabatake; Yasuaki Takasu; Toru Yagura; Akira Hattori; Kozue Nakajima; Shinichi Nishimura; Hideaki Kakeya
Chemical tagging of a drug target using 5-sulfonyl tetrazole.

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2013: Rafael Atillo Espiritu; Hideaki Kakeya; Nobuaki Matsumori; Shigeki Matsunaga; Michio Murata; Shinichi Nishimura; Minoru Yoshida
Interaction between the marine sponge cyclic peptide theonellamide A and sterols in lipid bilayers as viewed by surface plasmon resonance and solid-state (2)H nuclear magnetic resonance.
Biochemistry 2013;52(14):2410-8.
2013: Yuuki Nagamoto; Akira Hattori; Hideaki Kakeya; Yoshiji Takemoto; Kiyosei Takasu
pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols.
Chemical communications (Cambridge, England) 2013;49(26):2622-4.
2013: Satsuki Otsuki; Yuki Sakai; Hisae Takabatake; Yasuaki Takasu; Toru Yagura; Akira Hattori; Kozue Nakajima; Shinichi Nishimura; Hideaki Kakeya
Chemical tagging of a drug target using 5-sulfonyl tetrazole.
Bioorganic & medicinal chemistry letters 2013;23(6):1608-11.
2012: Yuji Ohno; Akira Hattori; Hideaki Kakeya
[C7orf24/gamma-glutamyl cyclotransferase as a molecular target for cancer chemotherapy].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 8():723-7.
2012: Yoichi Sunagawa; Hidetoshi Suzuki; Hiromichi Wada; Hiroki Sasaki; Akira Shimatsu; Masatoshi Fujita; Hiroyuki Fukuda; Koji Hasegawa; Tadashi Hashimoto; Atsushi Imaizumi; Hideaki Kakeya; Yasufumi Katanasaka; Takeshi Kimura; Tatsuya Morimoto
A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats.
Biological & pharmaceutical bulletin 2012;35(2):139-44.
2011: Yuji Ohno; Masamichi Ueda; Tatsuhiro Yoshiki; Akira Hattori; Susumu Kageyama; Hideaki Kakeya
Multiple NF-Y-binding CCAAT boxes are essential for transcriptional regulation of the human C7orf24 gene, a novel tumor-associated gene.
The FEBS journal 2011;278(21):4088-99.
2011: Yoichi Sunagawa; Tomohide Takaya; Hiromichi Wada; Shigeki Yanagi; Masatoshi Fujita; Hideaki Kakeya; Yasufumi Katanasaka; Teruhisa Kawamura; Takeshi Kimura; Akira Marui; Tatsuya Morimoto; Ryuzo Sakata; Akira Shimatsu; Koji Hasegawa
A natural p300-specific histone acetyltransferase inhibitor, curcumin, in addition to angiotensin-converting enzyme inhibitor, exerts beneficial effects on left ventricular systolic function after myocardial infarction in rats.
Circulation journal : official journal of the Japanese Circulation Society 2011;75(9):2151-9.
2011: Hiroki Sasaki; Yoichi Sunagawa; Kenji Takahashi; Atsushi Imaizumi; Hiroyuki Fukuda; Tadashi Hashimoto; Hiromichi Wada; Yasufumi Katanasaka; Hideaki Kakeya; Masatoshi Fujita; Koji Hasegawa; Tatsuya Morimoto
Innovative preparation of curcumin for improved oral bioavailability.
Biological & pharmaceutical bulletin 2011;34(5):660-5.
2010: Lisa Lindqvist; Francis Robert; William Merrick; Hideaki Kakeya; Christopher Fraser; Hiroyuki Osada; Jerry Pelletier
Inhibition of translation by cytotrienin A--a member of the ansamycin family.
RNA (New York, N.Y.) 2010;16(12):2404-13.
2010: Shinichi Nishimura; Yuko Arita; Miyuki Honda; Kunihiko Iwamoto; Akihisa Matsuyama; Atsuko Shirai; Hisashi Kawasaki; Hideaki Kakeya; Toshihide Kobayashi; Shigeki Matsunaga; Minoru Yoshida
Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling.
Nature chemical biology 2010;6(7):519-26.
2009: Yujiro Hayashi; Kuppusamy Sankar; Hayato Ishikawa; Yuriko Nozawa; Kazutoshi Mizoue; Hideaki Kakeya
Total synthesis and determination of the absolute configuration of FD-838, a naturally occurring azaspirobicyclic product.
Bioorganic & medicinal chemistry letters 2009;19(14):3863-5.
2009: Naoki Kato; Hirokazu Suzuki; Hiroshi Takagi; Yukihiro Asami; Hideaki Kakeya; Masakazu Uramoto; Takeo Usui; Shunji Takahashi; Yoshikazu Sugimoto; Hiroyuki Osada
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.
Chembiochem : a European journal of chemical biology 2009;10(5):920-8.
2008: Yukihiro Asami; Hideaki Kakeya; Yusuke Komi; Soichi Kojima; Kiyohiro Nishikawa; Kristin Beebe; Len Neckers; Hiroyuki Osada
Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation.
Cancer science 2008;99(9):1853-8.
2008: Hiroshi Kamiyama; Takeo Usui; Hiroaki Sakurai; Mitsuru Shoji; Yujiro Hayashi; Hideaki Kakeya; Hiroyuki Osada
Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.
Bioscience, biotechnology, and biochemistry 2008;72(7):1894-900.
2008: Hiteshkumar D Jain; Chunchun Zhang; Shuo Zhou; Hao Zhou; Jun Ma; Xiaoxiang Liu; Xuebin Liao; Amy M Deveau; Christine M Dieckhaus; Michael A Johnson; Kirsten S Smith; Timothy L MacDonald; Hideaki Kakeya; Hiroyuki Osada; James M Cook
Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein.
Bioorganic & medicinal chemistry 2008;16(8):4626-51.
2008: Hiroshi Kamiyama; Takeo Usui; Masakazu Uramoto; Hiroshi Takagi; Mitsuru Shoji; Yujiro Hayashi; Hideaki Kakeya; Hiroyuki Osada
Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation.
The Journal of antibiotics 2008;61(2):94-7.
2008: Yujiro Hayashi; Mitsuru Shoji; Hayato Ishikawa; Junichiro Yamaguchi; Tomohiro Tamura; Hiroki Imai; Yosuke Nishigaya; Kenichi Takabe; Hideaki Kakeya; Hiroyuki Osada
The asymmetric total synthesis of (+)-cytotrienin a, an ansamycin-type anticancer drug.
Angewandte Chemie (International ed. in English) 2008;47(35):6657-60.
2008: Hiroshi Kamiyama; Hideaki Kakeya; Takeo Usui; Kiyohiro Nishikawa; Mitsuru Shoji; Yujiro Hayashi; Hiroyuki Osada
Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR.
Oncology research 2008;17(1):11-21.
2007: Hideaki Kakeya
[Discovery of novel bioactive small molecules from microbial metabolites and chemical biology research].
The Japanese journal of antibiotics 2007;60(3):181-7.
2006: Masayoshi Matsuzawa; Hideaki Kakeya; Junichiro Yamaguchi; Mitsuru Shoji; Rie Onose; Hiroyuki Osada; Yujiro Hayashi
Enantio- and diastereoselective total synthesis of (+)-panepophenanthrin, a ubiquitin-activating enzyme inhibitor, and biological properties of its new derivatives.
Chemistry, an Asian journal 2006;1(6):845-51.
2006: Yukihiro Asami; Hideaki Kakeya; Gen Okada; Masakazu Toi; Hiroyuki Osada
RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus.
The Journal of antibiotics 2006;59(11):724-8.
2006: Kazuya Kikuchi; Hideaki Kakeya
A bridge between chemistry and biology.
Nature chemical biology 2006;2(8):392-4.
2006: Nobumoto Watanabe; Yoshifumi Nishihara; Tomoyuki Yamaguchi; Atsushi Koito; Hiroyuki Miyoshi; Hideaki Kakeya; Hiroyuki Osada
Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity.
FEBS letters 2006;580(11):2598-602.
2006: Isamu Shiina; Tadafumi Uchimaru; Mitsuru Shoji; Hideaki Kakeya; Hiroyuki Osada; Yujiro Hayashi
Computational study on the reaction mechanism of the key thermal [4 + 4] cycloaddition reaction in the biosynthesis of epoxytwinol A.
Organic letters 2006;8(6):1041-4.
2006: Junichiro Yamaguchi; Maya Toyoshima; Mitsuru Shoji; Hideaki Kakeya; Hiroyuki Osada; Yujiro Hayashi
Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin.
Angewandte Chemie (International ed. in English) 2006;45(5):789-93.
2006: Haruhiko Taguchi; Akihiro Ohkubo; Mitsuo Sekine; Kohji Seio; Hideaki Kakeya; Hiroyuki Osada; Takuma Sasaki
Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage.
Nucleosides, nucleotides & nucleic acids 2006;25(4-6):647-54.
2005: Mitsuru Shoji; Takao Uno; Hideaki Kakeya; Rie Onose; Isamu Shiina; Hiroyuki Osada; Yujiro Hayashi
Enantio- and diastereoselective total synthesis of EI-1941-1, -2, and -3, inhibitors of interleukin-1beta converting enzyme, and biological properties of their derivatives.
The Journal of organic chemistry 2005;70(24):9905-15.
2005: Tomokazu Mitsui; Yasunobu Miyake; Hideaki Kakeya; Yujiro Hayashi; Hiroyuki Osada; Takao Kataoka
RKTS-33, an epoxycyclohexenone derivative that specifically inhibits Fas ligand-dependent apoptosis in CTL-mediated cytotoxicity.
Bioscience, biotechnology, and biochemistry 2005;69(10):1923-8.
2005: Ho Jeong Kwon; Hideaki Kakeya
[Chemical genomics on new angiogenesis inhibitors].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2005;50(9):1056-62.
2005: Yujiro Hayashi; Mitsuru Shoji; Takasuke Mukaiyama; Hiroaki Gotoh; Shinpei Yamaguchi; Munetaka Nakata; Hideaki Kakeya; Hiroyuki Osada
First asymmetric total synthesis of synerazol, an antifungal antibiotic, and determination of its absolute stereochemistry.
The Journal of organic chemistry 2005;70(14):5643-54.
2005: Hideaki Kakeya; Rie Onose; Hiroyuki Koshino; Hiroyuki Osada
Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.
Chemical communications (Cambridge, England) 2005;(20):2575-7.
2005: Junichiro Yamaguchi; Hideaki Kakeya; Takao Uno; Mitsuru Shoji; Hiroyuki Osada; Yujiro Hayashi
Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells.
Angewandte Chemie (International ed. in English) 2005;44(20):3110-5.
2005: Yoko Nagumo; Hideaki Kakeya; Mitsuru Shoji; Yujiro Hayashi; Naoshi Dohmae; Hiroyuki Osada
Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity.
The Biochemical journal 2005;387(Pt 3):835-40.
2005: Mitsuru Shoji; Hiroki Imai; Makoto Mukaida; Ken Sakai; Hideaki Kakeya; Hiroyuki Osada; Yujiro Hayashi
Total synthesis of epoxyquinols A, B, and C and epoxytwinol A and the reactivity of a 2H-pyran derivative as the diene component in the Diels-Alder reaction.
The Journal of organic chemistry 2005;70(1):79-91.
2004: Mitsuo Sekine; Kazuhisa Okada; Kohji Seio; Tohru Obata; Takuma Sasaki; Hideaki Kakeya; Hiroyuki Osada
Synthesis of a biotin-conjugate of phosmidosine O-ethyl ester as a G1 arrest antitumor drug.
Bioorganic & medicinal chemistry 2004;12(24):6343-9.
2004: Mitsuo Sekine; Kazuhisa Okada; Kohji Seio; Hideaki Kakeya; Hiroyuki Osada; Takuma Sasaki
Structure-activity relationship of phosmidosine: importance of the 7,8-dihydro-8-oxoadenosine residue for antitumor activity.
Bioorganic & medicinal chemistry 2004;12(19):5193-201.
2004: Yoko Nagumo; Hideaki Kakeya; Junichiro Yamaguchi; Takao Uno; Mitsuru Shoji; Yujiro Hayashi; Hiroyuki Osada
Structure-activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity.
Bioorganic & medicinal chemistry letters 2004;14(17):4425-9.
2004: Yasunobu Miyake; Hideaki Kakeya; Hiroyuki Osada
[Mode of action and molecular target of ECH, a specific inhibitor of death receptor-dependent apoptosis].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(7):1283-9.
2004: Hideaki Kakeya; Hiroyuki Osada
[Development of novel angiogenesis inhibitors targeting VEGF (vascular endothelial growth factor) for cancer chemotherapy].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(7):1264-70.
2004: Hiroyuki Osada; Hideaki Kakeya
[Novel angiogenesis inhibitors for molecular target therapy of cancer].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(7):1257-63.
2004: Tomokazu Mitsui; Yasunobu Miyake; Hideaki Kakeya; Hiroyuki Osada; Takao Kataoka
ECH, an epoxycyclohexenone derivative that specifically inhibits Fas ligand-dependent apoptosis in CTL-mediated cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3428-36.
2004: Mitsuru Shoji; Hiroki Imai; Isamu Shiina; Hideaki Kakeya; Hiroyuki Osada; Yujiro Hayashi
Different reaction modes for the oxidative dimerization of epoxyquinols and epoxyquinones. Importance of intermolecular hydrogen-bonding.
The Journal of organic chemistry 2004;69(5):1548-56.
2004: Mitsuo Sekine; Kazuhisa Okada; Kohji Seio; Hideaki Kakeya; Hiroyuki Osada; Tohru Obata; Takuma Sasaki
Synthesis of chemically stabilized phosmidosine analogues and the structure--activity relationship of phosmidosine.
The Journal of organic chemistry 2004;69(2):314-26.
2003: Hideaki Kakeya; Yasunobu Miyake; Mitsuru Shoji; Satoshi Kishida; Yujiro Hayashi; Takao Kataoka; Hiroyuki Osada
Novel non-peptide inhibitors targeting death receptor-mediated apoptosis.
Bioorganic & medicinal chemistry letters 2003;13(21):3743-6.
2003: Yujiro Hayashi; Mitsuru Shoji; Shinpei Yamaguchi; Takasuke Mukaiyama; Junichiro Yamaguchi; Hideaki Kakeya; Hiroyuki Osada
Asymmetric total synthesis of pseurotin A.
Organic letters 2003;5(13):2287-90.
2003: Yasunobu Miyake; Hideaki Kakeya; Takao Kataoka; Hiroyuki Osada
Epoxycyclohexenone inhibits Fas-mediated apoptosis by blocking activation of pro-caspase-8 in the death-inducing signaling complex.
The Journal of biological chemistry 2003;278(13):11213-20.
2003: Kazuhisa Okada; Haruhiko Taguchi; Kohji Seio; Hideaki Kakeya; Hiroyuki Osada; Takuma Sasaki; Mitsuo Sekine
Synthesis and biological properties of stable phosmidosine analogs.
Nucleic acids research. Supplement (2001) 2003;(3):105-6.
2002: Hideaki Kakeya; Naoko Takahashi-Ando; Makoto Kimura; Rie Onose; Isamu Yamaguchi; Hiroyuki Osada
Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.
Bioscience, biotechnology, and biochemistry 2002;66(12):2723-6.
2002: Yujiro Hayashi; Mitsuru Shoji; Junichiro Yamaguchi; Kenji Sato; Shinpei Yamaguchi; Takasuke Mukaiyama; Ken Sakai; Yukihiro Asami; Hideaki Kakeya; Hiroyuki Osada
Asymmetric total synthesis of (-)-azaspirene, a novel angiogenesis inhibitor.
Journal of the American Chemical Society 2002;124(41):12078-9.
2002: Mitsuru Shoji; Junichiro Yamaguchi; Hideaki Kakeya; Hiroyuki Osada; Yujiro Hayashi
Total synthesis of (+)-epoxyquinols A and B.
Angewandte Chemie (International ed. in English) 2002;41(17):3192-4.
2002: Hideaki Kakeya; Rie Onose; Arika Yoshida; Hiroyuki Koshino; Hiroyuki Osada
Epoxyquinol B, a fungal metabolite with a potent antiangiogenic activity.
The Journal of antibiotics 2002;55(9):829-31.
2002: Yukihiro Asami; Hideaki Kakeya; Rie Onose; Arika Yoshida; Hiroshi Matsuzaki; Hiroyuki Osada
Azaspirene: a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya sp.
Organic letters 2002;4(17):2845-8.
2002: Naoko Takahashi-Ando; Makoto Kimura; Hideaki Kakeya; Hiroyuki Osada; Isamu Yamaguchi
A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning.
The Biochemical journal 2002;365(Pt 1):1-6.
2002: Hideaki Kakeya; Rie Onose; Hiroyuki Koshino; Arika Yoshida; Kimiko Kobayashi; Shun-Ichiro Kageyama; Hiroyuki Osada
Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites.
Journal of the American Chemical Society 2002;124(14):3496-7.
2001: Hideaki Kakeya; S Kageyama; L Nie; Rie Onose; Gen Okada; T Beppu; C J Norbury; Hiroyuki Osada
Lucilactaene, a new cell cycle inhibitor in p53-transfected cancer cells, produced by a Fusarium sp.
The Journal of antibiotics 2001;54(10):850-4.
2000: M Watabe; Hideaki Kakeya; Rie Onose; Hiroyuki Osada
Activation of MST/Krs and c-Jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis.
The Journal of biological chemistry 2000;275(12):8766-71.
1999: Hideaki Kakeya; Rie Onose; Hiroyuki Osada
Activation of a 36-kD MBP kinase, an active proteolytic fragment of MST/Krs proteins, during anticancer drug-induced apoptosis.
Annals of the New York Academy of Sciences 1999;886():273-5.
1998: Hideaki Kakeya; M Morishita; K Kobinata; M Osono; M Ishizuka; Hiroyuki Osada
Isolation and biological activity of a novel cytokine modulator, cytoxazone.
The Journal of antibiotics 1998;51(12):1126-8.
1998: Hideaki Kakeya; Rie Onose; Hiroyuki Osada
Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis.
Cancer research 1998;58(21):4888-94.
1998: Hideaki Kakeya; M Morishita; A Ikeno; K Kobinata; T Yano; Hiroyuki Osada
Factumycin and its new derivative RK-1009 enhance threonine-phosphorylation of a 60-kDa protein in Streptomyces griseus.
The Journal of antibiotics 1998;51(10):963-6.
1998: Hideaki Kakeya; Rie Onose; P C Liu; C Onozawa; F Matsumura; Hiroyuki Osada
Inhibition of cyclin D1 expression and phosphorylation of retinoblastoma protein by phosmidosine, a nucleotide antibiotic.
Cancer research 1998;58(4):704-10.
1998: K Togashi; Hideaki Kakeya; M Morishita; Y X Song; Hiroyuki Osada
Inhibition of human telomerase activity by alterperylenol.
Oncology research 1998;10(9):449-53.
1997: Hideaki Kakeya; M Morishita; C Onozawa; R Usami; K Horikoshi; K Kimura; M Yoshihama; Hiroyuki Osada
RKS-1778, a new mammalian cell-cycle inhibitor and a key intermediate of the [11]cytochalasin group.
Journal of natural products 1997;60(7):669-72.
1997: Hideaki Kakeya; H P Zhang; K Kobinata; Rie Onose; C Onozawa; T Kudo; Hiroyuki Osada
Cytotrienin A, a novel apoptosis inducer in human leukemia HL-60 cells.
The Journal of antibiotics 1997;50(4):370-2.
1997: Hideaki Kakeya; C Onozawa; M Sato; K Arai; Hiroyuki Osada
Neuritogenic effect of epolactaene derivatives on human neuroblastoma cells which lack high-affinity nerve growth factor receptors.
Journal of medicinal chemistry 1997;40(4):391-4.
1996: M Ubukata; T Morita; Hideaki Kakeya; K Kobinata; T Kudo; Hiroyuki Osada
Sparoxomycins A1 and A2, new inducers of the flat reversion of NRK cells transformed by temperature sensitive Rous sarcoma virus. I. Taxonomy of the producing organism, fermentation and biological activity.
The Journal of antibiotics 1996;49(11):1096-100.
1996: C B Cui; Hideaki Kakeya; Hiroyuki Osada
Spirotryprostatin B, a novel mammalian cell cycle inhibitor produced by Aspergillus fumigatus.
The Journal of antibiotics 1996;49(8):832-5.
1996: C B Cui; Hideaki Kakeya; Hiroyuki Osada
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures.
The Journal of antibiotics 1996;49(6):534-40.
1996: C B Cui; Hideaki Kakeya; G Okada; Rie Onose; Hiroyuki Osada
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties.
The Journal of antibiotics 1996;49(6):527-33.
1996: C B Cui; M Ubukata; Hideaki Kakeya; Rie Onose; G Okada; I Takahashi; K Isono; Hiroyuki Osada
Acetophthalidin, a novel inhibitor of mammalian cell cycle, produced by a fungus isolated from a sea sediment.
The Journal of antibiotics 1996;49(2):216-9.
1995: C B Cui; Hideaki Kakeya; G Okada; Rie Onose; M Ubukata; I Takahashi; K Isono; Hiroyuki Osada
Tryprostatins A and B, novel mammalian cell cycle inhibitors produced by Aspergillus fumigatus.
The Journal of antibiotics 1995;48(11):1382-4.
1995: Hideaki Kakeya; I Takahashi; G Okada; K Isono; Hiroyuki Osada
Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, produced by a marine fungus.
The Journal of antibiotics 1995;48(7):733-5.