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Yoshihiko Kakinuma

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Physiology

Energy Metabolism

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Publications

TOP 3
Michihiko Ueno; Yoshihiko Kakinuma; Koh-ichi Yuhki; Nobuyuki Murakoshi; Motoyuki Iemitsu; Takashi Miyauchi; Iwao Yamaguchi
Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo.
Masakatsu Takanashi; Takashi Miyauchi; Yoshihiko Kakinuma; Katsutoshi Goto; Iwao Yamaguchi
Establishment of hypoxia inducible factor-1alpha overexpressing cells that produce endothelin-1.
Shinichi Maki; Takashi Miyauchi; Yoshihiko Kakinuma; Satoshi Sakai; Tsutomu Kobayashi; Fumihiro Sugiyama; Akiyoshi Fukamizu; Katsutoshi Goto; Iwao Yamaguchi
The endothelin receptor antagonist ameliorates the hypertensive phenotypes of transgenic hypertensive mice with renin-angiotensin genes and discloses roles of organ specific activation of endothelin system in transgenic mice.

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2006: Michihiko Ueno; Yoshihiko Kakinuma; Koh-ichi Yuhki; Nobuyuki Murakoshi; Motoyuki Iemitsu; Takashi Miyauchi; Iwao Yamaguchi
Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo.
Journal of pharmacological sciences 2006;101(2):151-8.
2004: Masakatsu Takanashi; Takashi Miyauchi; Yoshihiko Kakinuma; Katsutoshi Goto; Iwao Yamaguchi
Establishment of hypoxia inducible factor-1alpha overexpressing cells that produce endothelin-1.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S268-73.
2004: Shinichi Maki; Takashi Miyauchi; Yoshihiko Kakinuma; Satoshi Sakai; Tsutomu Kobayashi; Fumihiro Sugiyama; Akiyoshi Fukamizu; Katsutoshi Goto; Iwao Yamaguchi
The endothelin receptor antagonist ameliorates the hypertensive phenotypes of transgenic hypertensive mice with renin-angiotensin genes and discloses roles of organ specific activation of endothelin system in transgenic mice.
Life sciences 2004;74(9):1105-18.
2003: Motoyuki Iemitsu; Takashi Miyauchi; Seiji Maeda; Satoshi Sakai; Nobuharu Fujii; Hitoshi Miyazaki; Yoshihiko Kakinuma; Mitsuo Matsuda; Iwao Yamaguchi
Cardiac hypertrophy by hypertension and exercise training exhibits different gene expression of enzymes in energy metabolism.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26(10):829-37.
2002: Nobuyuki Murakoshi; Takashi Miyauchi; Yoshihiko Kakinuma; Takashi Ohuchi; Katsutoshi Goto; Masashi Yanagisawa; Iwao Yamaguchi
Vascular endothelin-B receptor system in vivo plays a favorable inhibitory role in vascular remodeling after injury revealed by endothelin-B receptor-knockout mice.
Circulation 2002;106(15):1991-8.
2002: Yoshihiko Kakinuma; Takashi Miyauchi; Takahiko Suzuki; Koichi Yuki; Nobuyuki Murakoshi; Katsutoshi Goto; Iwao Yamaguchi
Enhancement of glycolysis in cardiomyocytes elevates endothelin-1 expression through the transcriptional factor hypoxia-inducible factor-1 alpha.
Clinical science (London, England : 1979) 2002;103 Suppl 48():210S-214S.
2001: K I Yuhki; Takashi Miyauchi; Yoshihiko Kakinuma; Nobuyuki Murakoshi; Seiji Maeda; Katsutoshi Goto; Iwao Yamaguchi; Takahiko Suzuki
Endothelin-1 production is enhanced by rotenone, a mitochondrial complex I inhibitor, in cultured rat cardiomyocytes.
Journal of cardiovascular pharmacology 2001;38(6):850-8.
2001: Koichi Yuki; Takahiko Suzuki; S Katoh; Yoshihiko Kakinuma; Takashi Miyauchi; Y Mitsui
Endothelin-1 stimulates cardiomyocyte injury during mitochondrial dysfunction in culture.
European journal of pharmacology 2001;431(2):163-70.
2001: Yoshihiko Kakinuma; Takashi Miyauchi; Koichi Yuki; Nobuyuki Murakoshi; Katsutoshi Goto; Iwao Yamaguchi
Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor hypoxia-inducible factor-1alpha induced for impaired myocardial energy metabolism.
Circulation 2001;103(19):2387-94.
2000: Koichi Yuki; Takashi Miyauchi; Yoshihiko Kakinuma; Nobuyuki Murakoshi; Takahiko Suzuki; J Hayashi; Katsutoshi Goto; Iwao Yamaguchi
Mitochondrial dysfunction increases expression of endothelin-1 and induces apoptosis through caspase-3 activation in rat cardiomyocytes in vitro.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S205-8.
2000: Yoshihiko Kakinuma; Takashi Miyauchi; Koichi Yuki; Nobuyuki Murakoshi; Katsutoshi Goto; Iwao Yamaguchi
Mitochondrial dysfunction of cardiomyocytes causing impairment of cellular energy metabolism induces apoptosis, and concomitant increase in cardiac endothelin-1 expression.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S201-4.
2000: Nobuyuki Murakoshi; Takashi Miyauchi; Yoshihiko Kakinuma; Koichi Yuki; Katsutoshi Goto; Iwao Yamaguchi
Impairment of cardiac energy metabolism in vivo causes hemodynamic abnormality and increases cardiac expression of preproendothelin-1 mRNA.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S128-31.
1999: Yoshihiko Kakinuma; Takashi Miyauchi; Tsutomu Kobayashi; Koichi Yuki; Seiji Maeda; Satoshi Sakai; Katsutoshi Goto; Iwao Yamaguchi
Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro and during heart failure in vivo.
Life sciences 1999;65(16):1671-83.