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T Kalland

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M Søgaard; Lennart Ohlsson; K Kristensson; Ann Rosendahl; A Sjoberg; Göran Forsberg; T Kalland; M Dohlsten
Treatment with tumor-reactive Fab-IL-2 and Fab-staphylococcal enterotoxin A fusion proteins leads to sustained T cell activation, and long-term survival of mice with established tumors.
L Grosse-Hovest; M Brandl; M Dohlsten; T Kalland; W Wilmanns; Gundram Jung
Tumor-growth inhibition with bispecific antibody fragments in a syngeneic mouse melanoma model: the role of targeted T-cell co-stimulation via CD28.
U Srinivas; M Dohlsten; T Kalland; Arne Lundblad
Staphylococcal enterotoxin-A-induced in-vitro adhesion of HL-60 cells to endothelial cells involves both selectin and integrin families of cell adhesion molecules.

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1999: M Søgaard; Lennart Ohlsson; K Kristensson; Ann Rosendahl; A Sjoberg; Göran Forsberg; T Kalland; M Dohlsten
Treatment with tumor-reactive Fab-IL-2 and Fab-staphylococcal enterotoxin A fusion proteins leads to sustained T cell activation, and long-term survival of mice with established tumors.
International journal of oncology 1999;15(5):873-82.
1999: L Grosse-Hovest; M Brandl; M Dohlsten; T Kalland; W Wilmanns; Gundram Jung
Tumor-growth inhibition with bispecific antibody fragments in a syngeneic mouse melanoma model: the role of targeted T-cell co-stimulation via CD28.
International journal of cancer. Journal international du cancer 1999;80(1):138-44.
1998: U Srinivas; M Dohlsten; T Kalland; Arne Lundblad
Staphylococcal enterotoxin-A-induced in-vitro adhesion of HL-60 cells to endothelial cells involves both selectin and integrin families of cell adhesion molecules.
Scandinavian journal of immunology 1998;48(2):127-35.
1998: Ann Rosendahl; K Kristensson; J Hansson; K Riesbeck; T Kalland; M Dohlsten
Perforin and IFN-gamma are involved in the antitumor effects of antibody-targeted superantigens.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5309-13.
1998: Ann Rosendahl; K Kristensson; J Hansson; Lennart Ohlsson; T Kalland; M Dohlsten
Repeated treatment with antibody-targeted superantigens strongly inhibits tumor growth.
International journal of cancer. Journal international du cancer 1998;76(2):274-83.
1998: Duane W Newton; M Dohlsten; PA Lando; T Kalland; C Olsson; Malak Kotb
MHC class II-independent, Vbeta-specific activation of T cells by superantigen mutants fused to anti-tumor Fab fragments: implications for use in treatment of human colon carcinoma.
International journal of molecular medicine 1998;1(1):157-62.
1998: Thomas H Tötterman; C Gidlöf; L Ragnarsson; E Högbom; M Lindeberg; N von der Lehr; A Einarsson; M Soegaard; K Kristensson; T Kalland; M Dohlsten
Targeted superantigens for immunotherapy of haematopoietic tumours.
Vox sanguinis 1998;74 Suppl 2():483-7.
1997: Ann Rosendahl; J Hansson; Per Antonsson; Rafick-Pierre Sékaly; T Kalland; M Dohlsten
A mutation of F47 to A in staphylococcus enterotoxin A activates the T-cell receptor Vbeta repertoire in vivo.
Infection and immunity 1997;65(12):5118-24.
1997: F Krull; Ursula Holzer; J Ihle; W Bethge; G Fierlbeck; T Kalland; M Dohlsten; Dietrich Niethammer; Guenther E Dannecker
Superantigen-induced lysis of melanoma cells.
Melanoma research 1997;7(3):214-22.
1997: LA Svensson; E M Schad; M Sundström; Per Antonsson; T Kalland; M Dohlsten
Staphylococcal enterotoxins A, D, and E. Structure and function, including mechanism of T-cell superantigenicity.
Preparative biochemistry & biotechnology 1997;27(2-3):111-41.
1997: Bruce Giantonio; R Katherine Alpaugh; J Schultz; Cecilia McAleer; Duane W Newton; B Shannon; Y Guedez; Malak Kotb; L Vitek; Robert Persson; Per Olov Gunnarsson; T Kalland; M Dohlsten; B Persson; Louis M Weiner
Superantigen-based immunotherapy: a phase I trial of PNU-214565, a monoclonal antibody-staphylococcal enterotoxin A recombinant fusion protein, in advanced pancreatic and colorectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(5):1994-2007.
1997: MJ Litton; M Dohlsten; J Hansson; Ann Rosendahl; Lennart Ohlsson; T Kalland; Jan Andersson; U Andersson
Tumor therapy with an antibody-targeted superantigen generates a dichotomy between local and systemic immune responses.
The American journal of pathology 1997;150(5):1607-18.
1997: Per Antonsson; AG Wingren; J Hansson; T Kalland; M Varga; M Dohlsten
Functional characterization of the interaction between the superantigen staphylococcal enterotoxin A and the TCR.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4245-51.
1997: Jacques Thibodeau; M Dohlsten; I Cloutier; Pauline Lavoie; P Bjork; F Michel; Claire Léveillé; Walid Mourad; T Kalland; Rafick-Pierre Sékaly
Molecular characterization and role in T cell activation of staphylococcal enterotoxin A binding to the HLA-DR alpha-chain.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3698-704.
1997: H Belfrage; M Dohlsten; G Hedlund; T Kalland
Prevention of superantigen-induced tolerance in vivo by interleukin-2 treatment.
Cancer immunology, immunotherapy : CII 1997;44(2):77-82.
1997: J Hansson; Lennart Ohlsson; Robert Persson; G Andersson; Nils-Gunnar Ilbäck; MJ Litton; T Kalland; M Dohlsten
Genetically engineered superantigens as tolerable antitumor agents.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2489-94.
1997: C Gidlöf; M Dohlsten; PA Lando; T Kalland; Christer Sundström; Thomas H Tötterman
A superantigen-antibody fusion protein for T-cell immunotherapy of human B-lineage malignancies.
Blood 1997;89(6):2089-97.
1997: E Parra; M Varga; G Hedlund; T Kalland; M Dohlsten
Costimulation by B7-1 and LFA-3 targets distinct nuclear factors that bind to the interleukin-2 promoter: B7-1 negatively regulates LFA-3-induced NF-AT DNA binding.
Molecular and cellular biology 1997;17(3):1314-23.
1997: tord labuda; E Parra; G Hedlund; T Kalland; M Dohlsten
The tumour associated cell surface antigen A6H is costimulatory for human CD4+ but not CD8+ T cells.
Immunology 1997;90(2):236-43.
1997: H Belfrage; M Dohlsten; G Hedlund; T Kalland
Prevention of superantigen-induced down-regulation of T-cell mediated cytotoxic activity by IL-2 in vivo.
Immunology 1997;90(2):183-8.
1997: E Parra; AG Wingren; G Hedlund; T Kalland; M Dohlsten
The role of B7-1 and LFA-3 in costimulation of CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):637-42.
1997: Ursula Holzer; Thorsten W Orlikowsky; C Zehrer; W Bethge; M Dohlsten; T Kalland; Dietrich Niethammer; Guenther E Dannecker
T-cell stimulation and cytokine release induced by staphylococcal enterotoxin A (SEA) and the SEAD227A mutant.
Immunology 1997;90(1):74-80.
1997: Anette Sundstedt; I Höiden; Ann Rosendahl; T Kalland; N van Rooijen; M Dohlsten
Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):180-6.
1996: C Zehrer; J Beck; V Gekeler; J Ihle; Ursula Holzer; M Dohlsten; T Kalland; Dietrich Niethammer; Guenther E Dannecker
Superantigen-mediated cellular cytotoxicity is dependent on antigen expression, but independent of the P-glycoprotein multidrug resistance phenotype.
British journal of haematology 1996;95(3):452-6.
1996: Duane W Newton; M Dohlsten; C Olsson; S Segrén; K E Lundin; PA Lando; T Kalland; Malak Kotb
Mutations in the MHC class II binding domains of staphylococcal enterotoxin A differentially affect T cell receptor Vbeta specificity.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):3988-94.
1996: PA Lando; C Olsson; T Kalland; Duane W Newton; Malak Kotb; M Dohlsten
Regulation of superantigen-induced T cell activation in the absence and the presence of MHC class II.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(7):2857-63.
1996: Ann Rosendahl; J Hansson; A Sundstedt; T Kalland; M Dohlsten
Immune response during tumor therapy with antibody-superantigen fusion proteins.
International journal of cancer. Journal international du cancer 1996;68(1):109-13.
1996: M Søgaard; J Hansson; M J Litton; Lennart Ohlsson; Ann Rosendahl; PA Lando; Per Antonsson; T Kalland; M Dohlsten
Antibody-targeted superantigens in cancer immunotherapy.
Immunotechnology : an international journal of immunological engineering 1996;2(3):151-62.
1996: A G Wingren; O Björkdahl; tord labuda; Lars Björk; U Andersson; Urban Gullberg; G Hedlund; Hans Sjögren; T Kalland; B Widegren; M Dohlsten
Fusion of a signal sequence to the interleukin-1 beta gene directs the protein from cytoplasmic accumulation to extracellular release.
Cellular immunology 1996;169(2):226-37.
1996: A Sundstedt; Mikael Sigvardsson; Tomas Leanderson; G Hedlund; T Kalland; M Dohlsten
In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):979-84.
1996: Per Antonsson; J Hansson; T Kalland; PA Lando; Lennart Ohlsson; E Schad; A Svensson; M Dohlsten
Genetically engineered superantigens in experimental tumor therapy.
Springer seminars in immunopathology 1996;17(4):397-410.
1996: M J Litton; M Dohlsten; PA Lando; T Kalland; Lennart Ohlsson; J Andersson; U Andersson
Antibody-targeted superantigen therapy induces tumor-infiltrating lymphocytes, excessive cytokine production, and apoptosis in human colon carcinoma.
European journal of immunology 1996;26(1):1-9.
1995: M Dohlsten; J Hansson; Lennart Ohlsson; M Litton; T Kalland
Antibody-targeted superantigens are potent inducers of tumor-infiltrating T lymphocytes in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9791-5.
1995: M Dohlsten; PA Lando; P Björk; L Abrahmsén; Lennart Ohlsson; P Lind; T Kalland
Immunotherapy of human colon cancer by antibody-targeted superantigens.
Cancer immunology, immunotherapy : CII 1995;41(3):162-8.
1995: C Gidlöf; M Dohlsten; T Kalland; Thomas H Tötterman
Antibodies are capable of directing superantigen-mediated T cell killing of chronic B lymphocytic leukemia cells.
Leukemia 1995;9(9):1534-42.
1995: tord labuda; PA Lando; O Björkdahl; T Kalland; R Vessella; G Hedlund; H Eriksson; Hans Sjögren; M Dohlsten
A novel co-stimulatory T cell antigen co-expressed on renal cell carcinoma.
International immunology 1995;7(9):1425-32.
1995: PA Lando; M Dohlsten; Lennart Ohlsson; T Kalland
Tumor-reactive superantigens suppress tumor growth in humanized SCID mice.
International journal of cancer. Journal international du cancer 1995;62(4):466-71.
1995: H Belfrage; M Dohlsten; G Hedlund; T Kalland
Enhanced and prolonged efficacy of superantigen-induced cytotoxic T lymphocyte activity by interleukin-2 in vivo.
Cancer immunology, immunotherapy : CII 1995;41(2):87-94.
1995: Ursula Holzer; Wolfgang A Bethge; F Krull; J Ihle; Rupert Handgretinger; R A Reisfeld; M Dohlsten; T Kalland; Dietrich Niethammer; Guenther E Dannecker
Superantigen-staphylococcal-enterotoxin-A-dependent and antibody-targeted lysis of GD2-positive neuroblastoma cells.
Cancer immunology, immunotherapy : CII 1995;41(2):129-36.
1995: E Parra; M Varga; Mikael Sigvardsson; G Hedlund; T Kalland; Tomas Leanderson; Hans Sjögren; M Dohlsten
Costimulation of human CD4+ T cells with LFA-3 and B7 induce distinct effects on AP-1 and NF-kappa B transcription factors.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1132-40.
1995: E M Schad; I Zaitseva; V N Zaitsev; M Dohlsten; T Kalland; P M Schlievert; D H Ohlendorf; LA Svensson
Crystal structure of the superantigen staphylococcal enterotoxin type A.
The EMBO journal 1995;14(14):3292-301.
1995: L Abrahmsén; M Dohlsten; S Segrén; P Björk; E Jonsson; T Kalland
Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A.
The EMBO journal 1995;14(13):2978-86.
1995: A Sundstedt; I Höidén; J Hansson; G Hedlund; T Kalland; M Dohlsten
Superantigen-induced anergy in cytotoxic CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(12):6306-13.
1995: J Ihle; Ursula Holzer; F Krull; M Dohlsten; T Kalland; Dietrich Niethammer; Guenther E Dannecker
Antibody-targeted superantigens induce lysis of major histocompatibility complex class II-negative T-cell leukemia lines.
Cancer research 1995;55(3):623-8.
1995: A G Wingren; E Parra; M Varga; T Kalland; Hans Sjögren; G Hedlund; M Dohlsten
T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles.
Critical reviews in immunology 1995;15(3-4):235-53.
1994: E Parra; A G Wingren; G Hedlund; M Björklund; Hans Sjögren; T Kalland; D Sansom; M Dohlsten
Costimulation of human CD4+ T lymphocytes with B7 and lymphocyte function-associated antigen-3 results in distinct cell activation profiles.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2479-87.
1994: A Sundstedt; M Dohlsten; G Hedlund; I Höidén; M Björklund; T Kalland
Superantigens anergize cytokine production but not cytotoxicity in vivo.
Immunology 1994;82(1):117-25.
1994: H Belfrage; P Bhiladvala; G Hedlund; M Dohlsten; T Kalland
Combined activation of murine lymphocytes with staphylococcal enterotoxin and interleukin-2 results in additive cytotoxic activity.
Cancer immunology, immunotherapy : CII 1994;38(4):265-71.
1993: E Parra; A G Wingren; G Hedlund; Hans Sjögren; T Kalland; D Sansom; M Dohlsten
Human naive and memory T-helper cells display distinct adhesion properties to ICAM-1, LFA-3 and B7 molecules.
Scandinavian journal of immunology 1993;38(6):508-14.
1993: E Akerblom; M Dohlsten; C Brynö; M Mastej; I Steringer; G Hedlund; PA Lando; T Kalland
Preparation and characterization of conjugates of monoclonal antibodies and staphylococcal enterotoxin A using a new hydrophilic cross-linker.
Bioconjugate chemistry 1993;4(6):455-66.
1993: PA Lando; M Dohlsten; G Hedlund; Thomas Brodin; D Sansom; T Kalland
Co-stimulation with B7 and targeted superantigen is required for MHC class II-independent T-cell proliferation but not cytotoxicity.
Immunology 1993;80(2):236-41.
1993: A Wallgren; R Festin; C Gidlöf; M Dohlsten; T Kalland; Thomas H Tötterman
Efficient killing of chronic B-lymphocytic leukemia cells by superantigen-directed T cells.
Blood 1993;82(4):1230-8.
1993: M Dohlsten; M Björklund; A Sundstedt; G Hedlund; D Samson; T Kalland
Immunopharmacology of the superantigen staphylococcal enterotoxin A in T-cell receptor V beta 3 transgenic mice.
Immunology 1993;79(4):520-7.
1993: A G Wingren; K Dahlenborg; M Björklund; G Hedlund; T Kalland; Hans Sjögren; A Ljungdahl; T Olsson; H P Ekre; D Sansom
Monocyte-regulated IFN-gamma production in human T cells involves CD2 signaling.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1328-36.
1993: M Dohlsten; A Sundstedt; M Björklund; G Hedlund; T Kalland
Superantigen-induced cytokines suppress growth of human colon-carcinoma cells.
International journal of cancer. Journal international du cancer 1993;54(3):482-8.
1993: PA Lando; M Dohlsten; G Hedlund; E Akerblom; T Kalland
T cell killing of human colon carcinomas by monoclonal-antibody-targeted superantigens.
Cancer immunology, immunotherapy : CII 1993;36(4):223-8.
1993: G Hedlund; M Dohlsten; C Petersson; T Kalland
Superantigen-based tumor therapy: in vivo activation of cytotoxic T cells.
Cancer immunology, immunotherapy : CII 1993;36(2):89-93.
1993: T Kalland; M Dohlsten; P Lind; A Sundstedt; L Abrahmsén; G Hedlund; P Björk; PA Lando; M Björklund
Monoclonal antibodies and superantigens: a novel therapeutic approach.
Medical oncology and tumor pharmacotherapy 1993;10(1-2):37-47.
1993: T Kalland; M Dohlsten; L Abrahmsén; G Hedlund; P Björk; PA Lando; A Sundstedt; E Akerblom; P Lind
Targeting of superantigens.
Cell biophysics 1993;22(1-3):147-64.
1992: J Hansson; P O Ericsson; M Dohlsten; Hans Sjögren; T Kalland; G Hedlund
Locally superantigen-activated peritoneal cytolytic T lymphocytes belong to the CD8+ CD45RC- subset and lyse MHC class II+ tumor cells.
Immunology letters 1992;34(3):229-36.
1992: A Gjörloff; G Hedlund; T Kalland; D Sansom; H Fischer; J Trowsdale; Hans Sjögren; M Dohlsten
The LFA-3 adhesion pathway is differently utilized by superantigen-activated human CD4+ T-cell subsets.
Scandinavian journal of immunology 1992;36(2):243-50.
1992: H Fischer; A Gjörloff; G Hedlund; H Hedman; E Lundgren; T Kalland; Hans Sjögren; M Dohlsten
Stimulation of human naive and memory T helper cells with bacterial superantigen. Naive CD4+45RA+ T cells require a costimulatory signal mediated through the LFA-1/ICAM-1 pathway.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):1993-8.
1991: G Hedlund; M Dohlsten; Thomas Herrmann; G Buell; PA Lando; S Segrén; J Schrimsher; H R MacDonald; Hans Sjögren; T Kalland
A recombinant C-terminal fragment of staphylococcal enterotoxin A binds to human MHC class II products but does not activate T cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(12):4082-5.
1991: M Dohlsten; G Hedlund; E Akerblom; PA Lando; T Kalland
Monoclonal antibody-targeted superantigens: a different class of anti-tumor agents.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(20):9287-91.
1991: PA Lando; G Hedlund; M Dohlsten; T Kalland
Bacterial superantigens as anti-tumour agents: induction of tumour cytotoxicity in human lymphocytes by staphylococcal enterotoxin A.
Cancer immunology, immunotherapy : CII 1991;33(4):231-7.
1991: T Kalland; G Hedlund; M Dohlsten; PA Lando
Staphylococcal enterotoxin-dependent cell-mediated cytotoxicity.
Current topics in microbiology and immunology 1991;174():81-92.
1990: H Fischer; G Hedlund; T Kalland; Hans Sjögren; M Dohlsten
Independent regulation of IFN-gamma and tumor necrosis factor by IL-1 in human T helper cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(11):3767-72.
1988: M Dohlsten; T Kalland; Hans Sjögren; R Carlsson
Histamine inhibits interleukin 1 production by lipopolysaccharide-stimulated human peripheral blood monocytes.
Scandinavian journal of immunology 1988;27(5):527-32.
1987: T Kalland; H Belfrage; P Bhiladvala; G Hedlund
Analysis of the murine lymphokine-activated killer (LAK) cell phenomenon: dissection of effectors and progenitors into NK- and T-like cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(11):3640-5.
1987: H Belfrage; P Bhiladvala; T Kalland
Functionally involved cell surface antigens on murine lymphokine activated killer cells.
Immunology letters 1987;14(4):293-8.