FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Tetsuya Kamataki

Research Profile

Chemicals & Drugs

Anatomy

Co-author Network

Publications

TOP 3
Miyuki Kimura; Kazuma Kiyotani; Kazuko Nakagawa; Makiko Shimizu; Tetsuya Kamataki; Hiroshi Yamazaki
Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokers.
Tomohisa Nakada; Tetsuya Saito; Takahiko Uno; Keiko Yamakawa; Hiroshi Yamazaki; Masanao Yokohira; Masaki Fujieda; Katsumi Imaida; Shunsuke Iwano; Kazuma Kiyotani; Tetsuya Kamataki
Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway.
Ken-Ichi Azuma; Alexander Lezhava; Makiko Shimizu; Yasumasa Kimura; Yuri Ishizu; Toshihisa Ishikawa; Tetsuya Kamataki; Yoshihide Hayashizaki; Hiroshi Yamazaki
Direct genotyping of Cytochrome P450 2A6 whole gene deletion from human blood samples by the SmartAmp method.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Tetsuya Kamataki (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Miyuki Kimura; Kazuma Kiyotani; Kazuko Nakagawa; Makiko Shimizu; Tetsuya Kamataki; Hiroshi Yamazaki
Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokers.
Drug metabolism letters 2012;6(2):67-72.
2012: Tomohisa Nakada; Tetsuya Saito; Takahiko Uno; Keiko Yamakawa; Hiroshi Yamazaki; Masanao Yokohira; Masaki Fujieda; Katsumi Imaida; Shunsuke Iwano; Kazuma Kiyotani; Tetsuya Kamataki
Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway.
The Journal of toxicological sciences 2012;37(3):555-63.
2011: Ken-Ichi Azuma; Alexander Lezhava; Makiko Shimizu; Yasumasa Kimura; Yuri Ishizu; Toshihisa Ishikawa; Tetsuya Kamataki; Yoshihide Hayashizaki; Hiroshi Yamazaki
Direct genotyping of Cytochrome P450 2A6 whole gene deletion from human blood samples by the SmartAmp method.
Clinica chimica acta; international journal of clinical chemistry 2011;412(13-14):1249-51.
2011: Norihito Shibahara; Hiroshi Yamazaki; Shunsuke Iwano; Kazuma Kiyotani; Yuiko Masunaga; Tetsuya Kamataki
Human cytochrome P450 1A1 is a novel target gene of liver X receptor α.
Drug metabolism and pharmacokinetics 2011;26(5):451-7.
2010: Kazuma Kiyotani; Makiko Shimizu; Toshio Kumai; Tetsuya Kamataki; Shinichi Kobayashi; Hiroshi Yamazaki
Limited effects of frequent CYP2D6*36-*10 tandem duplication allele on in vivo dextromethorphan metabolism in a Japanese population.
European journal of clinical pharmacology 2010;66(10):1065-8.
2010: Taku Nagano; Makiko Shimizu; Kazuma Kiyotani; Tetsuya Kamataki; Ryohji Takano; Norie Murayama; Fumiaki Shono; Hiroshi Yamazaki
Biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male Japanese population.
International journal of environmental research and public health 2010;7(7):2953-64.
2009: K Murai; Hiroshi Yamazaki; Kazuko Nakagawa; R Kawai; Tetsuya Kamataki
Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes.
Xenobiotica; the fate of foreign compounds in biological systems 2009;39(11):795-802.
2009: Hijiri Takeuchi; Kousuke Saoo; Yoko Matsuda; Masanao Yokohira; Keiko Yamakawa; Yu Zeng; Toshiya Kuno; Tetsuya Kamataki; Katsumi Imaida
8-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.
Molecular medicine reports 2009;2(4):585-8.
2009: Masayuki Matsunaga; Hiroshi Yamazaki; Kazuma Kiyotani; Shunsuke Iwano; Jyunji Saruwatari; Kazuko Nakagawa; Akiko Soyama; Shogo Ozawa; Jun-Ichi Sawada; Eiji Kashiyama; Moritoshi Kinoshita; Tetsuya Kamataki
Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(4):699-701.
2009: Yasuhiro Uno; Tsukasa Ohuchi; Shotaro Uehara; Go Kito; Tetsuya Kamataki; Ryoichi Nagata
Sex-related differences in the expression of mfGSTA2, a novel GST identified in cynomolgus monkey (Macaca fascicularis).
Drug metabolism and disposition: the biological fate of chemicals 2009;37(3):453-6.
2009: Shunji Kuribayashi; Kiyoto Goto; Shinsaku Naito; Tetsuya Kamataki; Hiroshi Yamazaki
Human cytochrome P450 1A2 involvement in the formation of reactive metabolites from a species-specific hepatotoxic pyrazolopyrimidine derivative, 5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidine.
Chemical research in toxicology 2009;22(2):323-31.
2008: Ken-ichi Fujita; Wataru Yamamoto; Shoji Endo; Hisashi Endo; Fumio Nagashima; Wataru Ichikawa; Ryuhei Tanaka; Toshimichi Miya; Kazuhiro Araki; Keiji Kodama; Yu Sunakawa; Masaru Narabayashi; Keisuke Miwa; Yuichi Ando; Yuko Akiyama; Kaori Kawara; Tetsuya Kamataki; Yasutsuna Sasaki
CYP2A6 and the plasma level of 5-chloro-2, 4-dihydroxypyridine are determinants of the pharmacokinetic variability of tegafur and 5-fluorouracil, respectively, in Japanese patients with cancer given S-1.
Cancer science 2008;99(5):1049-54.
2007: Yasuhiro Uno; Shinya Hosaka; Kiyomi Matsuno; Chika Nakamura; Go Kito; Tetsuya Kamataki; Ryoichi Nagata
Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: is CYP2C76 the only monkey-specific CYP gene responsible for species differences in drug metabolism?
Archives of biochemistry and biophysics 2007;466(1):98-105.
2007: Yoko Matsuda; Kousuke Saoo; Keiko Yamakawa; Masanao Yokohira; Satoshi Suzuki; Toshiya Kuno; Tetsuya Kamataki; Katsumi Imaida
Overexpression of CYP2A6 in human colorectal tumors.
Cancer science 2007;98(10):1582-5.
2007: Yoko Matsuda; Keiko Yamakawa; Kousuke Saoo; Kyoko Hosokawa; Masanao Yokohira; Toshiya Kuno; Junko Iwai; Takatoshi Shirai; Kaoru Obika; Tetsuya Kamataki; Katsumi Imaida
CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
Oncology reports 2007;18(1):53-7.
2007: Yasumasa Mitani; Alexander Lezhava; Yuki Kawai; Takeshi Kikuchi; Atsuko Oguchi-Katayama; Yasushi Kogo; Masayoshi Itoh; Toru Miyagi; Hideki Takakura; Kanako Hoshi; Chiaki Kato; Takahiro Arakawa; Kazuhiro Shibata; Kenji Fukui; Ryoji Masui; Seiki Kuramitsu; Kazuma Kiyotani; Alistair Chalk; Katsuhiko Tsunekawa; Masami Murakami; Tetsuya Kamataki; Takanori Oka; Hiroshi Shimada; Paul E Cizdziel; Yoshihide Hayashizaki
Rapid SNP diagnostics using asymmetric isothermal amplification and a new mismatch-suppression technology.
Nature methods 2007;4(3):257-62.
2007: Yasuhiro Uno; T Kumano; Go Kito; Ryoichi Nagata; Tetsuya Kamataki; H Fujino
CYP2C76-mediated species difference in drug metabolism: a comparison of pitavastatin metabolism between monkeys and humans.
Xenobiotica; the fate of foreign compounds in biological systems 2007;37(1):30-43.
2007: Hiroshi Yamazaki; Haruka Fujita; Takaaki Gunji; Jun Zhang; Tetsuya Kamataki; John R Cashman; Makiko Shimizu
Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.
Molecular genetics and metabolism 2007;90(1):58-63.
2006: Sompop Peamkrasatam; Kampon Sriwatanakul; Kazuma Kiyotani; Masaki Fujieda; Hiroshi Yamazaki; Tetsuya Kamataki; Krongtong Yoovathaworn
In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais.
Drug metabolism and pharmacokinetics 2006;21(6):475-84.
2006: Tetsuya Kamataki
[How I was enticed into molecular toxicology].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2006;126(12):1309-18.
2006: Junji Saruwatari; Masayuki Matsunaga; Kazuyuki Ikeda; Masashi Nakao; Kentaro Oniki; Takayuki Seo; Shuichi Mihara; Toru Marubayashi; Tetsuya Kamataki; Kazuko Nakagawa
Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia.
European journal of clinical pharmacology 2006;62(12):995-1001.
2006: Devrim Sarikaya; Cem Bilgen; Tetsuya Kamataki; Zeki Topcu
Comparative cytochrome P450 -1A1, -2A6, -2B6, -2C, -2D6, -2E1, -3A5 and -4B1 expressions in human larynx tissue analysed at mRNA level.
Biopharmaceutics & drug disposition 2006;27(8):353-9.
2006: Yasuhiro Uno; Hideki Fujino; Go Kito; Tetsuya Kamataki; Ryoichi Nagata
CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone.
Molecular pharmacology 2006;70(2):477-86.
2006: S Kuribayashi; N Ueda; S Naito; H Yamazaki; Tetsuya Kamataki
Species differences in hydrolase activities toward OT-7100 responsible for different bioavailability in rats, dogs, monkeys and humans.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(4):301-14.
2006: Hijiri Takeuchi; Kousuke Saoo; Yoko Matsuda; Masanao Yokohira; Keiko Yamakawa; Yu Zeng; Masafumi Miyazaki; Masaki Fujieda; Tetsuya Kamataki; Katsumi Imaida
Dose dependent inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice.
Cancer letters 2006;234(2):232-8.
2006: Shunsuke Iwano; Norihito Shibahara; Tetsuya Saito; Tetsuya Kamataki
Activation of p53 as a causal step for atherosclerosis induced by polycyclic aromatic hydrocarbons.
FEBS letters 2006;580(3):890-3.
2005: Tetsuya Kamataki; Masaki Fujieda; Kazuma Kiyotani; Shunsuke Iwano; Hideo Kunitoh
Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk.
Biochemical and biophysical research communications 2005;338(1):306-10.
2005: Shunsuke Iwano; Fumie Asanuma; Manabu Nukaya; Tetsuya Saito; Tetsuya Kamataki
CYP1A1-mediated mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons.
Biochemical and biophysical research communications 2005;337(2):708-12.
2005: Masafumi Miyazaki; Hiroshi Yamazaki; Hijiri Takeuchi; Kousuke Saoo; Masanao Yokohira; Ken-ichi Masumura; Takehiko Nohmi; Yoshihiko Funae; Katsumi Imaida; Tetsuya Kamataki
Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.
Carcinogenesis 2005;26(11):1947-55.
2005: Shunsuke Iwano; Manabu Nukaya; Tetsuya Saito; Fumie Asanuma; Tetsuya Kamataki
A possible mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons.
Biochemical and biophysical research communications 2005;335(1):220-6.
2005: Miyuki Kimura; Hiroshi Yamazaki; Masaki Fujieda; Kazuma Kiyotani; Goro Honda; Junji Saruwatari; Kazuko Nakagawa; Takashi Ishizaki; Tetsuya Kamataki
Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(9):1361-6.
2005: Tetsuya Kamataki
[Tailor-made medicine].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2005;126(1):60-5.
2005: Hiroshi Yamazaki; Masaki Fujieda; John R Cashman; Tetsuya Kamataki
Mild trimethylaminuria observed in a Japanese cohort with liver damage.
The American journal of medicine 2005;118(7):803-5.
2005: Katsunori Nakamura; Noritaka Ariyoshi; Takafumi Iwatsubo; Yasuhisa Fukunaga; Saburou Higuchi; Kunio Itoh; Noriaki Shimada; Kazuo Nagashima; Tsuyoshi Yokoi; Koujirou Yamamoto; Ryuya Horiuchi; Tetsuya Kamataki
Inhibitory effects of nicardipine to cytochrome P450 (CYP) in human liver microsomes.
Biological & pharmaceutical bulletin 2005;28(5):882-5.
2005: Megumi Endo; Yoshiki Takahashi; Yasumasa Sasaki; Tetsuya Saito; Tetsuya Kamataki
Novel gender-related regulation of CYP2C12 gene expression in rats.
Molecular endocrinology (Baltimore, Md.) 2005;19(5):1181-90.
2005: Masafumi Miyazaki; Eika Sugawara; Teruki Yoshimura; Hiroshi Yamazaki; Tetsuya Kamataki
Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108.
Mutation research 2005;581(1-2):165-71.
2005: Maxwell Afari Gyamfi; Masaki Fujieda; Kazuma Kiyotani; Hiroshi Yamazaki; Tetsuya Kamataki
High prevalence of cytochrome P450 2A6*1A alleles in a black African population of Ghana.
European journal of clinical pharmacology 2005;60(12):855-7.
2005: Satoshi Yamaori; Hiroshi Yamazaki; Shunsuke Iwano; Kazuma Kiyotani; Keiko Matsumura; Tetsuya Saito; Andrew Parkinson; Kazuko Nakagawa; Tetsuya Kamataki
Ethnic differences between Japanese and Caucasians in the expression levels of mRNAs for CYP3A4, CYP3A5 and CYP3A7: lack of co-regulation of the expression of CYP3A in Japanese livers.
Xenobiotica; the fate of foreign compounds in biological systems 2005;35(1):69-83.
2004: Masuhiro Nishimura; Teruko Imai; Yujiro Morioka; Shunji Kuribayashi; Tetsuya Kamataki; Shinsaku Naito
Effects of NO-1886 (Ibrolipim), a lipoprotein lipase-promoting agent, on gene induction of cytochrome P450s, carboxylesterases, and sulfotransferases in primary cultures of human hepatocytes.
Drug metabolism and pharmacokinetics 2004;19(6):422-9.
2004: Masaki Fujieda; Hiroshi Yamazaki; Tetsuya Saito; Kazuma Kiyotani; Maxwell Afari Gyamfi; Masaharu Sakurai; Hirotoshi Dosaka-Akita; Yuichi Sawamura; Jun Yokota; Hideo Kunitoh; Tetsuya Kamataki
Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers.
Carcinogenesis 2004;25(12):2451-8.
2004: Noritaka Ariyoshi; Hiromi Sekine; Kazuo Nakayama; Katsuhiko Saito; Atsushi Miyamoto; Tetsuya Kamataki
Identification of deletion-junction site of CYP2A6*4B allele lacking entire coding region of CYP2A6 in Japanese.
Pharmacogenetics 2004;14(10):701-5.
2004: Yoshiyuki Yamazaki; Ken-Ichi Fujita; Kazuo Nakayama; Akihiro Suzuki; Katsunori Nakamura; Hiroshi Yamazaki; Tetsuya Kamataki
Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens.
Mutation research 2004;562(1-2):151-62.
2004: Motonobu Furukawa; Masuhiro Nishimura; Daisuke Ogino; Ryoji Chiba; Iwao Ikai; Nobuhiko Ueda; Shinsaku Naito; Shunji Kuribayashi; Mohsen A Moustafa; Takafumi Uchida; Hideki Sawada; Tetsuya Kamataki; Yoshihiko Funae; Manabu Fukumoto
Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver.
Cancer science 2004;95(6):520-9.
2004: Hiroshi Yamazaki; Masaki Fujieda; Masahiro Togashi; Tetsuya Saito; George Preti; John R Cashman; Tetsuya Kamataki
Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients.
Life sciences 2004;74(22):2739-47.
2004: Satoshi Yamaori; Hiroshi Yamazaki; Shunsuke Iwano; Kazuma Kiyotani; Keiko Matsumura; Goro Honda; Kazuko Nakagawa; Takashi Ishizaki; Tetsuya Kamataki
CYP3A5 Contributes significantly to CYP3A-mediated drug oxidations in liver microsomes from Japanese subjects.
Drug metabolism and pharmacokinetics 2004;19(2):120-9.
2004: Tsutomu Sakuma; Tsukasa Shimojima; Kiyoshi Miwa; Tetsuya Kamataki
Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(4):376-8.
2004: Kenji Toide; Yoshiaki Terauchi; Toshihiko Fujii; Hiroshi Yamazaki; Tetsuya Kamataki
Uridine diphosphate sugar-selective conjugation of an aldose reductase inhibitor (AS-3201) by UDP-glucuronosyltransferase 2B subfamily in human liver microsomes.
Biochemical pharmacology 2004;67(7):1269-78.
2004: Keiko Matsumura; Tetsuya Saito; Yoshiki Takahashi; Takeshi Ozeki; Kazuma Kiyotani; Masaki Fujieda; Hiroshi Yamazaki; Hideo Kunitoh; Tetsuya Kamataki
Identification of a novel polymorphic enhancer of the human CYP3A4 gene.
Molecular pharmacology 2004;65(2):326-34.
2004: Manabu Nukaya; Yoshiki Takahashi; Frank J Gonzalez; Tetsuya Kamataki
Aryl hydrocarbon receptor-mediated suppression of GH receptor and Janus kinase 2 expression in mice.
FEBS letters 2004;558(1-3):96-100.
2003: Satoshi Yamaori; Hiroshi Yamazaki; Akihiro Suzuki; Ayako Yamada; Hirofumi Tani; Tamio Kamidate; Ken ichi Fujita; Tetsuya Kamataki
Effects of cytochrome b(5) on drug oxidation activities of human cytochrome P450 (CYP) 3As: similarity of CYP3A5 with CYP3A4 but not CYP3A7.
Biochemical pharmacology 2003;66(12):2333-40.
2003: Hijiri Takeuchi; Kousuke Saoo; Masanao Yokohira; Mico Ikeda; Hajime Maeta; Masafumi Miyazaki; Hiroshi Yamazaki; Tetsuya Kamataki; Katsumi Imaida
Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.
Cancer research 2003;63(22):7581-3.
2003: Kazuma Kiyotani; Hiroshi Yamazaki; Masaki Fujieda; Shunsuke Iwano; Keiko Matsumura; Soisungwan Satarug; Pailin Ujjin; Tsutomu Shimada; F Peter Guengerich; Andrew Parkinson; Goro Honda; Kazuko Nakagawa; Takashi Ishizaki; Tetsuya Kamataki
Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9).
Pharmacogenetics 2003;13(11):689-95.
2003: Dai Mizuno; Yoshiki Takahashi; Toyoko Hiroi; Susumu Imaoka; Tetsuya Kamataki; Yoshihiko Funae
A novel transcriptional element which regulates expression of the CYP2D4 gene by Oct-1 and YY-1 binding.
Biochimica et biophysica acta 2003;1627(2-3):121-8.
2003: Masahiko Ando; Nobuyuki Hamajima; Noritaka Ariyoshi; Tetsuya Kamataki; Keitaro Matsuo; Yoshiyuki Ohno
Association of CYP2A6 gene deletion with cigarette smoking status in Japanese adults.
Journal of epidemiology / Japan Epidemiological Association 2003;13(3):176-81.
2003: Takashi Satoh; Haruka Munakata; Ken-ichi Fujita; Shinji Itoh; Shungo Itoh; Tetsuya Kamataki; Itsuo Yoshizawa
Studies on the interactions between drug and estrogen. II. On the inhibitory effect of 29 drugs reported to induce gynecomastia on the oxidation of estradiol at C-2 or C-17.
Biological & pharmaceutical bulletin 2003;26(5):695-700.
2003: Kenji Toide; Hiroshi Yamazaki; Rikako Nagashima; Keisuke Itoh; Shunsuke Iwano; Yoshiki Takahashi; Shaw Watanabe; Tetsuya Kamataki
Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells: trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003;12(3):219-22.
2003: Masaki Fujieda; Hiroshi Yamazaki; Masahiro Togashi; Tetsuya Saito; Tetsuya Kamataki
Two novel single nucleotide polymorphisms (SNPs) of the FMO3 gene in Japanese.
Drug metabolism and pharmacokinetics 2003;18(5):333-5.
2003: Hiroshi Yamazaki; Kazuma Kiyotani; Satoshi Tsubuko; Masayuki Matsunaga; Masaki Fujieda; Tetsuya Saito; Jun Miura; Shinichi Kobayashi; Tetsuya Kamataki
Two novel haplotypes of CYP2D6 gene in a Japanese population.
Drug metabolism and pharmacokinetics 2003;18(4):269-71.
2003: Tetsuya Saito; Mari Egashira; Kazuma Kiyotani; Masaki Fujieda; Hiroshi Yamazaki; Chikako Kiyohara; Hideo Kunitoh; Tetsuya Kamataki
Novel nonsynonymous polymorphisms of the CYP1A1 gene in Japanese.
Drug metabolism and pharmacokinetics 2003;18(3):218-21.
2003: Poh-Sing Ng; Susumu Imaoka; Toyoko Hiroi; Mayuko Osada; Toshio Niwa; Tetsuya Kamataki; Yoshihiko Funae
Production of inhibitory polyclonal antibodies against cytochrome P450s.
Drug metabolism and pharmacokinetics 2003;18(3):163-72.
2003: Masaki Fujieda; Hiroshi Yamazaki; Kazuma Kiyotani; Asami Muroi; Hideo Kunitoh; Hirotoshi Dosaka-Akita; Yuichi Sawamura; Tetsuya Kamataki
Eighteen novel polymorphisms of the CYP2A13 gene in Japanese.
Drug metabolism and pharmacokinetics 2003;18(1):86-90.
2003: Yoichi Kanamori; Ken-Ichi Fujita; Kazuo Nakayama; Hideki Kawai; Tetsuya Kamataki
Large-scale production of genetically engineered CYP3A4 in E. coli: application of a jarfermenter.
Drug metabolism and pharmacokinetics 2003;18(1):42-7.
2003: Takeshi Ozeki; Yoshiki Takahashi; Kazuo Nakayama; Masato Funayama; Kazuo Nagashima; Takao Kodama; Tetsuya Kamataki
Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers.
Pharmacogenetics 2003;13(1):49-53.
2002: Michihiro Chida; Noritaka Ariyoshi; Tsuyoshi Yokoi; Nobuo Nemoto; Makoto Inaba; Moritoshi Kinoshita; Tetsuya Kamataki
New allelic arrangement CYP2D6*36 x 2 found in a Japanese poor metabolizer of debrisoquine.
Pharmacogenetics 2002;12(8):659-62.
2002: Eizo Takahashi; Ken-ichi Fujita; Tetsuya Kamataki; Sakae Arimoto-Kobayashi; Keinosuke Okamoto; Tomoe Negishi
Inhibition of human cytochrome P450 1B1, 1A1 and 1A2 by antigenotoxic compounds, purpurin and alizarin.
Mutation research 2002;508(1-2):147-56.
2002: Takeshi Ozeki; Yoshiki Takahashi; Kazuo Nakayama; Tetsuya Kamataki
Hepatocyte nuclear factor (HNF)-4 alpha/gamma, HNF-1 alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene.
Archives of biochemistry and biophysics 2002;405(2):185-90.
2002: Noritaka Ariyoshi; Masami Miyamoto; Yuri Umetsu; Hideo Kunitoh; Hirotoshi Dosaka-Akita; Yu-Ichi Sawamura; Jun Yokota; Nobuo Nemoto; Kunio Sato; Tetsuya Kamataki
Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(9):890-4.
2002: Tetsuya Kamataki; Ken-ichi Fujita; Kazuo Nakayama; Yoshiyuki Yamazaki; Masami Miyamoto; Noritaka Ariyoshi
Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP.
Drug metabolism reviews 2002;34(3):667-76.
2002: Junji Saruwatari; Kazuko Nakagawa; Junichi Shindo; Takahiro Tajiri; Masaki Fujieda; Hiroshi Yamazaki; Tetsuya Kamataki; Takashi Ishizaki
A population phenotyping study of three drug-metabolizing enzymes in Kyushu, Japan, with use of the caffeine test.
Clinical pharmacology and therapeutics 2002;72(2):200-8.
2002: Noritaka Ariyoshi; Hiromi Sekine; Katsuhiko Saito; Tetsuya Kamataki
Characterization of a genotype previously designated as CYP2A6 D-type: CYP2A6*4B, another entire gene deletion allele of the CYP2A6 gene in Japanese.
Pharmacogenetics 2002;12(6):501-4.
2002: Satoshi Daigo; Yoshiki Takahashi; Masaki Fujieda; Noritaka Ariyoshi; Hiroshi Yamazaki; Wasaburo Koizumi; Satoshi Tanabe; Katsunori Saigenji; Sekio Nagayama; Kazumasa Ikeda; Yasuhiko Nishioka; Tetsuya Kamataki
A novel mutant allele of the CYP2A6 gene (CYP2A6*11 ) found in a cancer patient who showed poor metabolic phenotype towards tegafur.
Pharmacogenetics 2002;12(4):299-306.
2002: Kenji Toide; Yoshiki Takahashi; Hiroshi Yamazaki; Yoshiaki Terauchi; Toshihiko Fujii; Andrew Parkinson; Tetsuya Kamataki
Hepatocyte nuclear factor-1alpha is a causal factor responsible for interindividual differences in the expression of UDP-glucuronosyltransferase 2B7 mRNA in human livers.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(6):613-5.
2002: Katsunori Nakamura; Noritaka Ariyoshi; Tsuyoshi Yokoi; Satoru Ohgiya; Michihiro Chida; Kazuo Nagashima; Kazuaki Inoue; Takao Kodama; Noriaki Shimada; Tetsuya Kamataki
CYP2D6.10 present in human liver microsomes shows low catalytic activity and thermal stability.
Biochemical and biophysical research communications 2002;293(3):969-73.
2002: Noritaka Ariyoshi; Mitsukazu Kitada; Tetsuya Kamataki
[Association between genetic polymorphism and lung cancer risk].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 5():46-9.
2002: Masaki Fujieda; Hiroshi Yamazaki; Tetsuya Kamataki
[Genetic polymorphisms of drug metabolizing enzymes].
Gan to kagaku ryoho. Cancer & chemotherapy 2002;29(5):663-8.
2002: Hiroshi Yamazaki; Tetsuya Kamataki
[P450 and carcinogenesis].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2002;119(4):208-12.
2002: Zeki Topcu; Itsuo Chiba; Masaki Fujieda; Toshiyuki Shibata; Noritaka Ariyoshi; Hiroshi Yamazaki; Figen Sevgican; Malsantha Muthumala; Hiroshi Kobayashi; Tetsuya Kamataki
CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka.
Carcinogenesis 2002;23(4):595-8.
2002: Pailin Ujjin; Soisungwan Satarug; Yuvaree Vanavanitkun; Satoshi Daigo; Noritaka Ariyoshi; Hiroshi Yamazaki; Paul E B Reilly; Michael R Moore; Tetsuya Kamataki
Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females.
Pharmacogenetics 2002;12(3):241-9.
2002: Kazuma Kiyotani; Masaki Fujieda; Hiroshi Yamazaki; Tsutomu Shimada; F Peter Guengerich; Andrew Parkinson; Kazuko Nakagawa; Takashi Ishizaki; Tetsuya Kamataki
Twenty one novel single nucleotide polymorphisms (SNPs) of the CYP2A6 gene in Japanese and Caucasians.
Drug metabolism and pharmacokinetics 2002;17(5):482-7.
2002: Megumi Kubota; Yoko Nakamoto; Kazuo Nakayama; Pailin Ujjin; Soisungwan Satarug; Taisei Mushiroda; Tsuyoshi Yokoi; Masato Funayama; Tetsuya Kamataki
A mutation in the flavin-containing monooxygenase 3 gene and its effects on catalytic activity for N-oxidation of trimethylamine in vitro.
Drug metabolism and pharmacokinetics 2002;17(3):207-13.
2002: Kenji Toide; Shin-Ichiro Umeda; Hiroshi Yamazaki; Yoshiki Takahashi; Yoshiaki Terauchi; Toshihiko Fujii; Tetsuya Kamataki
A major genotype in UDP-glucuronosyltransferase 2B15.
Drug metabolism and pharmacokinetics 2002;17(2):164-6.
2002: Kazuma Kiyotani; Hiroshi Yamazaki; Masaki Fujieda; Satoshi Daigo; Soisungwan Satarug; Pailin Ujjin; Tetsuya Kamataki
Novel mutations of the CYP2A6 gene in a Thai population with lowered capacity of coumarin 7-hydroxylation.
Drug metabolism and pharmacokinetics 2002;17(2):161-3.
2002: Ken-Ichi Fujita; Tetsuya Kamataki
Genetically engineered bacterial cells co-expressing human cytochrome P450 with NADPH-cytochrome P450 reductase: prediction of metabolism and toxicity of drugs in humans.
Drug metabolism and pharmacokinetics 2002;17(1):1-22.
2002: Tetsuya Kamataki; Ken-Ichi Fujita
Mutagenesis testing based on bacterial expression of human P450s.
Methods in enzymology 2002;357():301-10.
2002: Takanori Hashizume; Susumu Imaoka; Masashi Mise; Yoshiaki Terauchi; Toshihiko Fujii; Hisashi Miyazaki; Tetsuya Kamataki; Yoshihiko Funae
Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes.
The Journal of pharmacology and experimental therapeutics 2002;300(1):298-304.
2001: Ken-ichi Fujita; Tetsuya Kamataki
Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase.
Mutation research 2001;483(1-2):35-41.
2001: Tetsuya Saito; Yoshiki Takahashi; H Hashimoto; Tetsuya Kamataki
Novel transcriptional regulation of the human CYP3A7 gene by Sp1 and Sp3 through nuclear factor kappa B-like element.
The Journal of biological chemistry 2001;276(41):38010-22.
2001: Kazuo Nakayama; Y Sudo; Y Sasaki; H Iwata; M Takahashi; Tetsuya Kamataki
Studies on transcriptional regulation of Cyp3a16 gene in mouse livers by application of direct DNA injection method.
Biochemical and biophysical research communications 2001;287(4):820-4.
2001: Jason R Baker; Soisungwan Satarug; Paul E B Reilly; Robert J Edwards; N Ariyoshi; Tetsuya Kamataki; Michael R Moore; David J Williams
Relationships between non-occupational cadmium exposure and expression of nine cytochrome P450 forms in human liver and kidney cortex samples.
Biochemical pharmacology 2001;62(6):713-21.
2001: M Nukaya; Y Takahashi; F J Gonzalez; Tetsuya Kamataki
Aryl hydrocarbon receptor-mediated suppression of expression of the low-molecular-weight prekininogen gene in mice.
Biochemical and biophysical research communications 2001;287(1):301-4.
2001: Shunsuke Iwano; Tetsuya Saito; Yoshiki Takahashi; K Fujita; Tetsuya Kamataki
Cooperative regulation of CYP3A5 gene transcription by NF-Y and Sp family members.
Biochemical and biophysical research communications 2001;286(1):55-60.
2001: S Muto; Ken-ichi Fujita; Yoshiyuki Yamazaki; Tetsuya Kamataki
Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450.
Mutation research 2001;479(1-2):197-206.
2001: K Fujita ; Tetsuya Kamataki
Screening of organosulfur compounds as inhibitors of human CYP2A6.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(7):983-9.
2001: Susumu Imaoka; K Hayashi; Toyoko Hiroi; Y Yabusaki; Tetsuya Kamataki; Yoshihiko Funae
A transgenic mouse expressing human CYP4B1 in the liver.
Biochemical and biophysical research communications 2001;284(3):757-62.
2001: Takanori Hashizume; Masashi Mise; Satoshi Matsumoto; Yoshiaki Terauchi; Toshihiko Fujii; Susumu Imaoka; Yoshihiko Funae; Tetsuya Kamataki; Hisashi Miyazaki
A novel cytochrome P450 enzyme responsible for the metabolism of ebastine in monkey small intestine.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(6):798-805.
2001: T Ozeki; Y Takahashi; T Kume; K Nakayama; T Yokoi; K Nunoya; A Hara; Tetsuya Kamataki
Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo-keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4alpha/gamma and HNF-1alpha.
The Biochemical journal 2001;355(Pt 2):537-44.
2001: N Ariyoshi; Y Sawamura ; Tetsuya Kamataki
A novel single nucleotide polymorphism altering stability and activity of CYP2a6.
Biochemical and biophysical research communications 2001;281(3):810-4.
2001: N Ariyoshi; M Miyazaki; K Toide; Tetsuya Kamataki
A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation.
Biochemical and biophysical research communications 2001;281(5):1256-60.
2001: Takanori Hashizume; Susumu Imaoka; Toyoko Hiroi; Yoshiaki Terauchi; Toshihiko Fujii; Hisashi Miyazaki; Tetsuya Kamataki; Yoshihiko Funae
cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine.
Biochemical and biophysical research communications 2001;280(4):1135-41.
2001: Yoshiki Takahashi; Tetsuya Kamataki
Competitive inhibition of the transcription of rabbit CYP1A1 gene by upstream stimulatory factor 1 (USF1).
Drug metabolism reviews 2001;33(1):37-47.
2001: Taisei Mushiroda; Noritaka Ariyoshi; Tsuyoshi Yokoi; E Takahara; O Nagata; H Kato; Tetsuya Kamataki
Accumulation of the 1-methyl-4-phenylpyridinium ion in suncus (Suncus murinus) brain: implication for flavin-containing monooxygenase activity in brain microvessels.
Chemical research in toxicology 2001;14(2):228-32.
2001: Marie-Anne Loriot; S Rebuissou; Mikael Oscarson; Sylvie Cenée; M Miyamoto; Noritaka Ariyoshi; Tetsuya Kamataki; Denis Hémon; Philippe Beaune; Isabelle Stücker
Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population.
Pharmacogenetics 2001;11(1):39-44.
2001: Ken-ichi Fujita; Tetsuya Kamataki
Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase.
Environmental and molecular mutagenesis 2001;38(4):339-46.
2001: Ken-ichi Fujita; Kazuo Nakayama; Yoshiyuki Yamazaki; K Tsuruma; M Yamada; T Nohmi; Tetsuya Kamataki
Construction of Salmonella typhimurium YG7108 strains, each coexpressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase.
Environmental and molecular mutagenesis 2001;38(4):329-38.
2000: H Kushida; K Fujita; A Suzuki; M Yamada; T Nohmi; Tetsuya Kamataki
Development of a Salmonella tester strain sensitive to promutagenic N-nitrosamines: expression of recombinant CYP2A6 and human NADPH-cytochrome P450 reductase in S. typhimurium YG7108.
Mutation research 2000;471(1-2):135-43.
2000: Takashi Satoh; K I Fujita; H Munakata; Shinji Itoh; K Nakamura; Tetsuya Kamataki; S Itoh; Itsuo Yoshizawa
Studies on the interactions between drugs and estrogen: analytical method for prediction system of gynecomastia induced by drugs on the inhibitory metabolism of estradiol using Escherichia coli coexpressing human CYP3A4 with human NADPH-cytochrome P450 reductase.
Analytical biochemistry 2000;286(2):179-86.
2000: Noritaka Ariyoshi; Yoshiki Takahashi; M Miyamoto; Yuri Umetsu; Satoshi Daigo; T Tateishi; S Kobayashi; Y Mizorogi; Marie-Anne Loriot; Isabelle Stücker; Philippe Beaune; M Kinoshita; Tetsuya Kamataki
Structural characterization of a new variant of the CYP2A6 gene (CYP2A6*1B) apparently diagnosed as heterozygotes of CYP2A6*1A and CYP2A6*4C.
Pharmacogenetics 2000;10(8):687-93.
2000: Taisei Mushiroda; Tsuyoshi Yokoi; K Itoh; K Nunoya; T Nakagawa; M Kubota; E Takahara; O Nagata; H Kato; Tetsuya Kamataki
The house musk shrew (Suncus murinus): a unique animal with extremely low level of expression of mRNAs for CYP3A and flavin-containing monooxygenase.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2000;126(3):225-34.
2000: H Kushida; K Fujita; A Suzuki; M Yamada; T Endo; T Nohmi; Tetsuya Kamataki
Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase.
Carcinogenesis 2000;21(6):1227-32.
2000: E Inoue; Yoshiki Takahashi; Y Imai; Tetsuya Kamataki
Development of bacterial expression system with high yield of CYP3A7, a human fetus-specific form of cytochrome P450.
Biochemical and biophysical research communications 2000;269(2):623-7.
2000: Taisei Mushiroda; Noritaka Ariyoshi; K Kimura; E Takahara; O Nagata; H Kato; Tetsuya Kamataki
A high-level expression of CYP2A in the lung of the suncus (Suncus murinus) and its role in the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Biochemical and biophysical research communications 2000;269(2):393-6.
2000: Taisei Mushiroda; Tsuyoshi Yokoi; E Takahara; O Nagata; H Kato; Tetsuya Kamataki
The suncus (Suncus murinus) shows poor metabolic phenotype for trimethylamine N-oxygenation.
Toxicology and applied pharmacology 2000;162(1):44-8.
1999: Y Sasaki; Yoshiki Takahashi; Kazuo Nakayama; Tetsuya Kamataki
Cooperative regulation of CYP2C12 gene expression by STAT5 and liver-specific factors in female rats.
The Journal of biological chemistry 1999;274(52):37117-24.
1999: T Kume; H Iwasa; H Shiraishi; Tsuyoshi Yokoi; K Nagashima; M Otsuka; T Terada; T Takagi; A Hara; Tetsuya Kamataki
Characterization of a novel variant (S145C/L311V) of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver.
Pharmacogenetics 1999;9(6):763-71.
1999: Taisei Mushiroda; Tsuyoshi Yokoi; E Takahara; O Nagata; H Kato; Tetsuya Kamataki
Sensitive assay of trimethylamine N-oxide in liver microsomes by headspace gas chromatography with flame thermionic detection.
Journal of chromatography. B, Biomedical sciences and applications 1999;734(2):319-23.
1999: M Chida; Tsuyoshi Yokoi; Y Kosaka; K Chiba; H Nakamura; T Ishizaki; J Yokota; M Kinoshita; K Sato; M Inaba; Y Aoki; F J Gonzalez; Tetsuya Kamataki
Genetic polymorphism of CYP2D6 in the Japanese population.
Pharmacogenetics 1999;9(5):601-5.
1999: M Chida; T Yokoi; T Fukui; M Kinoshita; J Yokota; Tetsuya Kamataki
Detection of three genetic polymorphisms in the 5'-flanking region and intron 1 of human CYP1A2 in the Japanese population.
Japanese journal of cancer research : Gann 1999;90(9):899-902.
1999: Tetsuya Kamataki; A Suzuki; H Kushida; H Iwata; M Watanabe; T Nohmi; K Fujita
Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocylic amines.
Cancer letters 1999;143(2):113-6.
1999: Timothy H Marczylo; T Hayatsu; Sakae Arimoto-Kobayashi; M Tada; K Fujita; Tetsuya Kamataki; K Nakayama; Hikoya Hayatsu
Protection against the bacterial mutagenicity of heterocyclic amines by purpurin, a natural anthraquinone pigment.
Mutation research 1999;444(2):451-61.
1999: M Miyamoto; Yuri Umetsu; H Dosaka-Akita; Y Sawamura; J Yokota; Hideo Kunitoh; N Nemoto; K Sato; Noritaka Ariyoshi; Tetsuya Kamataki
CYP2A6 gene deletion reduces susceptibility to lung cancer.
Biochemical and biophysical research communications 1999;261(3):658-60.
1999: E Kashiyama; Tsuyoshi Yokoi; M Odomi; Tetsuya Kamataki
Stereoselective S-oxidation and reduction of flosequinan in rat.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(8):815-26.
1999: K Nunoya; T Yokoi; Yoshiki Takahashi; K Kimura; M Kinoshita; Tetsuya Kamataki
Homologous unequal cross-over within the human CYP2A gene cluster as a mechanism for the deletion of the entire CYP2A6 gene associated with the poor metabolizer phenotype.
Journal of biochemistry 1999;126(2):402-7.
1999: M Chida; Tsuyoshi Yokoi; N Nemoto; M Inaba; M Kinoshita; Tetsuya Kamataki
A new variant CYP2D6 allele (CYP2D6*21) with a single base insertion in exon 5 in a Japanese population associated with a poor metabolizer phenotype.
Pharmacogenetics 1999;9(3):287-93.
1999: T Tateishi; Michihiro Chida; Noritaka Ariyoshi; Y Mizorogi; Tetsuya Kamataki; Shinichi Kobayashi
Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese population.
Clinical pharmacology and therapeutics 1999;65(5):570-5.
1999: M Nakajima; T Yokoi; M Mizutani; M Kinoshita; M Funayama; Tetsuya Kamataki
Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans.
Journal of biochemistry 1999;125(4):803-8.
1999: K I Nunoya; Tsuyoshi Yokoi; K Kimura; T Kainuma; K Satoh; M Kinoshita; Tetsuya Kamataki
A new CYP2A6 gene deletion responsible for the in vivo polymorphic metabolism of (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride in humans.
The Journal of pharmacology and experimental therapeutics 1999;289(1):437-42.
1999: S Muto; T Yokoi; Y Gondo; M Katsuki; Y Shioyama; Ken-ichi Fujita; Tetsuya Kamataki
Inhibition of benzo[a]pyrene-induced mutagenesis by (-)-epigallocatechin gallate in the lung of rpsL transgenic mice.
Carcinogenesis 1999;20(3):421-4.
1998: Y Ando; T Shimizu; K Nakamura; T Mushiroda; T Nakagawa; T Kodama; Tetsuya Kamataki
Potent and non-specific inhibition of cytochrome P450 by JM216, a new oral platinum agent.
British journal of cancer 1998;78(9):1170-4.
1998: Yuichi Ando; Hideo Saka; Gyo Asai; S Sugiura; Kaoru Shimokata; Tetsuya Kamataki
UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1998;9(8):845-7.
1998: Y Ando; M Chida; K Nakayama; Hideo Saka; Tetsuya Kamataki
The UGT1A1*28 allele is relatively rare in a Japanese population.
Pharmacogenetics 1998;8(4):357-60.
1998: Tsuyoshi Yokoi; Tetsuya Kamataki
[Genetic polymorphism of drug metabolizing enzymes: new mutations in CYP2D6 and CYP2A6 genes in Japanese].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1998;112(1):5-14.
1998: T Sakuma; M Hieda; T Igarashi; S Ohgiya; R Nagata; N Nemoto; Tetsuya Kamataki
Molecular cloning and functional analysis of cynomolgus monkey CYP1A2.
Biochemical pharmacology 1998;56(1):131-9.
1998: Y Takahashi; C Suzuki; Tetsuya Kamataki
Silencing of CYP1A1 expression in rabbits by DNA methylation.
Biochemical and biophysical research communications 1998;247(2):383-6.
1998: K Nunoya; Tsuyoshi Yokoi; K Kimura; K Inoue; T Kodama; M Funayama; K Nagashima; Y Funae; C Green; M Kinoshita; Tetsuya Kamataki
A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502).
Pharmacogenetics 1998;8(3):239-49.
1998: T Mori; S Itoh; Tetsuya Kamataki
Molecular cloning and regulation of a novel guinea pig cytochrome P450 (CYP3A20) which differs from guinea pig CYP3A14 in only two amino acid residues.
Biochemistry and molecular biology international 1998;44(6):1245-53.
1998: A Suzuki; H Kushida; H Iwata; M Watanabe; T Nohmi; K Fujita; F J Gonzalez; Tetsuya Kamataki
Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocyclic amines.
Cancer research 1998;58(9):1833-8.
1998: H Iwata; K Fujita; H Kushida; A Suzuki; Y Konno; K Nakamura; A Fujino; Tetsuya Kamataki
High catalytic activity of human cytochrome P450 co-expressed with human NADPH-cytochrome P450 reductase in Escherichia coli.
Biochemical pharmacology 1998;55(8):1315-25.
1998: Tsuyoshi Yokoi; Tetsuya Kamataki
Genetic polymorphism of drug metabolizing enzymes: new mutations in CYP2D6 and CYP2A6 genes in Japanese.
Pharmaceutical research 1998;15(4):517-24.
1997: T Mori; S Itoh; S Ohgiya; K Ishizaki; Tetsuya Kamataki
Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs.
Archives of biochemistry and biophysics 1997;348(2):268-77.
1997: Y Takahashi; K Nakayama; Satsuki Itoh; Y Fujii-Kuriyama; Tetsuya Kamataki
Inhibition of the transcription of CYP1A1 gene by the upstream stimulatory factor 1 in rabbits. Competitive binding of USF1 with AhR.Arnt complex.
The Journal of biological chemistry 1997;272(48):30025-31.
1997: Y Takahashi; K Nakayama; Satsuki Itoh; Tetsuya Kamataki
Upstream stimulatory factor 1 (USF1) suppresses induction of CYP1A1 mRNA by 3-methylcholanthrene (MC) in HepG2 cells.
Biochemical and biophysical research communications 1997;240(2):293-7.
1997: T Sakuma; T Igarashi; M Hieda; S Ohgiya; M Isogai; S Ninomiya; R Nagata; N Nemoto; Tetsuya Kamataki
Marmoset CYP1A2: primary structure and constitutive expression in livers.
Carcinogenesis 1997;18(10):1985-91.
1997: Elizabeth M J Gillam; Rebecca M Wunsch; Y F Ueng; Tsutomu Shimada; Paul E B Reilly; Tetsuya Kamataki; F Peter Guengerich
Expression of cytochrome P450 3A7 in Escherichia coli: effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductase.
Archives of biochemistry and biophysics 1997;346(1):81-90.
1997: A Kubo; S Itoh; K Itoh; Tetsuya Kamataki
Determination of FAD-binding domain in flavin-containing monooxygenase 1 (FMO1).
Archives of biochemistry and biophysics 1997;345(2):271-7.
1997: Satoru Ohgiya; T Goda; T Hoshino; Tetsuya Kamataki; K Ishizaki
Establishment of a novel host, high-red yeast that stably expresses hamster NADPH-cytochrome P450 oxidoreductase: usefulness for examination of the function of mammalian cytochrome P450.
Archives of biochemistry and biophysics 1997;343(2):215-24.
1997: E Kashiyama; Tsuyoshi Yokoi; M Odomi; Y Funae; K Inoue; Tetsuya Kamataki
Cytochrome P450 responsible for the stereoselective S-oxidation of flosequinan in hepatic microsomes from rats and humans.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(6):716-24.
1997: S Itoh; T Matsuyama; Tetsuya Kamataki
Low activity of aldehyde dehydrogenase (ALDH) in liver of Suncus murinus: possible explanation for high sensitivity to alcohol.
The Journal of toxicological sciences 1997;22(2):111-5.
1997: T Yanagimoto; S Itoh; M Sawada; Tetsuya Kamataki
Mouse cytochrome P450 (Cyp3a11): predominant expression in liver and capacity to activate aflatoxin B1.
Archives of biochemistry and biophysics 1997;340(2):215-8.
1997: T Igarashi; T Sakuma; M Isogai; R Nagata; Tetsuya Kamataki
Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs.
Archives of biochemistry and biophysics 1997;339(1):85-91.
1997: Y Li; Tsuyoshi Yokoi; M Katsuki; Jia-Sheng Wang; John Groopman; Tetsuya Kamataki
In vivo activation of aflatoxin B1 in C57BL/6N mice carrying a human fetus-specific CYP3A7 gene.
Cancer research 1997;57(4):641-5.
1997: S Itoh; Y Abe; A Kubo; M Okuda; M Shimoji; K Nakayama; Tetsuya Kamataki
Isolation of a promoter region in mouse cytochrome P450 3A (Cyp3A16) gene and its transcriptional control.
Biochimica et biophysica acta 1997;1350(2):155-8.
1997: K Itoh; K Nakamura; T Kimura; S Itoh; Tetsuya Kamataki
Molecular cloning of mouse liver flavin containing monooxygenase (FMO1) cDNA and characterization of the expression product: metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ).
The Journal of toxicological sciences 1997;22(1):45-56.
1997: H Nakura; S Itoh; H Kusano; H Ishizone; Tetsuya Kamataki
Opposite effects of isoniazid and fasting on the expression of CYP2E1 protein and mRNA in house musk shrew (Suncus murinus).
Biochemistry and molecular biology international 1997;41(2):293-301.
1997: K Toide; S Itoh; Y Nagasaka; T Yanagimoto; Tetsuya Kamataki
Gene structure of mouse Cyp3a11: evidence for an enhancer element within its 5' flanking sequences.
Archives of biochemistry and biophysics 1997;338(1):43-9.
1996: Y Takahashi; K Nakayama; T Shimojima; S Itoh; Tetsuya Kamataki
Expression of aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (Arnt) in adult rabbits known to be non-responsive to cytochrome P-450 1A1 (CYP1A1) inducers.
European journal of biochemistry / FEBS 1996;242(3):512-8.
1996: Tetsuya Kamataki; Tsuyoshi Yokoi; Y Yamayoshi; K Nakamura; H Kushida; K Fujita; H Mitsuhashi; T Ueno
Strategic proposals to avoid toxic drug interactions during new drug development: molecular toxicology proposals.
The Journal of toxicological sciences 1996;21(5):305-8.
1996: Y Li; Tsuyoshi Yokoi; M Sasaki; K Hattori; M Katsuki; Tetsuya Kamataki
Perinatal expression and inducibility of human CYP3A7 in C57BL/6N transgenic mice.
Biochemical and biophysical research communications 1996;228(2):312-7.
1996: K Nakamura; Tsuyoshi Yokoi; K Inoue; Noriaki Shimada; N Ohashi; T Kume; Tetsuya Kamataki
CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes.
Pharmacogenetics 1996;6(5):449-57.
1996: Tsuyoshi Yokoi; Y Kosaka; M Chida; K Chiba; H Nakamura; T Ishizaki; M Kinoshita; K Sato; F J Gonzalez; Tetsuya Kamataki
A new CYP2D6 allele with a nine base insertion in exon 9 in a Japanese population associated with poor metabolizer phenotype.
Pharmacogenetics 1996;6(5):395-401.
1996: T Nakagawa; M Sawada; F J Gonzalez; Tsuyoshi Yokoi; Tetsuya Kamataki
Stable expression of human CYP2E1 in Chinese hamster cells: high sensitivity to N,N-dimethylnitrosamine in cytotoxicity testing.
Mutation research 1996;360(3):181-6.
1996: M Shimoji; S Itoh; K Toide; K Nakayama; S Aizawa; Tetsuya Kamataki
Application of primary hepatocytes from p53-knockout mice for studies of expression of Cyp3a.
Journal of biochemistry 1996;120(1):42-8.
1996: Y Li; Tsuyoshi Yokoi; R Kitamura; M Sasaki; M Gunji; M Katsuki; Tetsuya Kamataki
Establishment of transgenic mice carrying human fetus-specific CYP3A7.
Archives of biochemistry and biophysics 1996;329(2):235-240.
1996: K Nunoya; Y Yokoi; K Kimura; T Kodama; M Funayama; K Inoue; K Nagashima; Y Funae; N Shimada; C Green; Tetsuya Kamataki
(+)-cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes.
The Journal of pharmacology and experimental therapeutics 1996;277(2):768-74.
1995: M Shimoji; K Hattori; S Itoh; K Nakayama; M Katsuki; S Aizawa; Tsuyoshi Yokoi; Tetsuya Kamataki
Establishment of immortal hepatocytes from a CYP3A7-transgenic/p53-knockout mouse.
Biochemical and biophysical research communications 1995;217(3):1001-5.
1995: K Nunoya; Tsuyoshi Yokoi; K Itoh; S Itoh; K Kimura; Tetsuya Kamataki
S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride by rat hepatic flavin-containing monooxygenase 1 expressed in yeast.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(12):1283-91.
1995: Tetsuya Kamataki; H Hashimoto; M Shimoji; S Itoh; K Nakayama; K Hattori; Tsuyoshi Yokoi; M Katsuki; S Aizawa
Expression of CYP3A7, a human fetus-specific cytochrome P450, in cultured cells and in the hepatocytes of p53-knockout mice.
Toxicology letters 1995;82-83():879-82.
1995: H Nakura; S Itoh; H Kusano; H Ishizone; T Deguchi; Tetsuya Kamataki
Evidence for the lack of hepatic N-acetyltransferase in suncus (Suncus murinus).
Biochemical pharmacology 1995;50(8):1165-70.
1995: Tsuyoshi Yokoi; M Narita; E Nagai; H Hagiwara; M Aburada; Tetsuya Kamataki
Inhibition of UDP-glucuronosyltransferase by aglycons of natural glucuronides in kampo medicines using SN-38 as a substrate.
Japanese journal of cancer research : Gann 1995;86(10):985-9.
1995: H Hashimoto; Y Yanagawa; M Sawada; S Itoh; T Deguchi; Tetsuya Kamataki
Simultaneous expression of human CYP3A7 and N-acetyltransferase in Chinese hamster CHL cells results in high cytotoxicity for carcinogenic heterocyclic amines.
Archives of biochemistry and biophysics 1995;320(2):323-9.
1995: T Sakuma; T Yokoi; Tetsuya Kamataki
Hormonal regulation of the mRNA level of male-dominant cytochrome P450 (CYP2C27) in hamster livers.
Pharmacological research : the official journal of the Italian Pharmacological Society 1995;31(6):371-4.
1995: T Sakuma; Tsuyoshi Yokoi; Tetsuya Kamataki
Isolation and characterization of a new cDNA clone belonging to the cytochrome P450 2C gene subfamily in hamsters.
Archives of biochemistry and biophysics 1995;319(1):267-73.
1995: Tetsuya Kamataki
[Molecular toxicology of cytochrome P450: focusing on interspecies homology].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1995;115(5):370-7.
1995: H Hashimoto; T Nakagawa; Tsuyoshi Yokoi; M Sawada; S Itoh; Tetsuya Kamataki
Fetus-specific CYP3A7 and adult-specific CYP3A4 expressed in Chinese hamster CHL cells have similar capacity to activate carcinogenic mycotoxins.
Cancer research 1995;55(4):787-91.
1995: Tsuyoshi Yokoi; S Nagayama; R Kajiwara; Y Kawaguchi; T Aizawa; Y Otaki; M Aburada; Tetsuya Kamataki
Occurrence of autoimmune antibodies to liver microsomal proteins associated with lethal hepatitis in LEC rats: effects of TJN-101 ((+)-(6S,7S,R-biar)- 5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy-6,7-dimethyl-10,11- methylenedioxy-6-dibenzo[a,c]cyclooctenol) on the development of hepatitis and the autoantibodies.
Toxicology letters 1995;76(1):33-8.
1995: T Sakuma; R Kitamura; Tsuyoshi Yokoi; Tetsuya Kamataki
Efficient complementary DNA directed expression of human fetal liver cytochrome P450 (CYP3A7) in insect cells using baculovirus.
Biochemistry and molecular biology international 1995;35(2):447-55.
1995: Tsuyoshi Yokoi; M Sawada; Tetsuya Kamataki
Polymorphic drug metabolism: studies with recombinant Chinese hamster cells and analyses in human populations.
Pharmacogenetics 1995;5 Spec No():S65-9.
1994: S Itoh; M Satoh; Y Abe; H Hashimoto; T Yanagimoto; Tetsuya Kamataki
A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA cloning and expression in fetal liver.
European journal of biochemistry / FEBS 1994;226(3):877-82.
1994: T Yanagimoto; S Itoh; M Sawada; H Hashimoto; Tetsuya Kamataki
Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1).
Biochimica et biophysica acta 1994;1201(3):405-10.
1994: T Kato; Hiromitsu Nakasa; Shigeru Ohmori; Tetsuya Kamataki; K Itahashi; T Shimada; T Rikihisa; Mitsukazu Kitada
Possible occurrence of P450 related to P450 HFLb in extrahepatic tissues of human fetuses and its contribution to metabolic activation of promutagens.
Mutation research 1994;310(1):73-7.
1994: Y Takahashi; S Itoh; T Shimojima; Tetsuya Kamataki
Characterization of Ah receptor promoter in human liver cell line, HepG2.
Pharmacogenetics 1994;4(4):219-22.
1994: S Nagayama; Tsuyoshi Yokoi; H Tanaka; Y Kawaguchi; T Shirasaka; Tetsuya Kamataki
Occurrence of autoantibody to protein disulfide isomerase in patients with hepatic disorder.
The Journal of toxicological sciences 1994;19(3):163-9.
1994: S Nagayama; Tsuyoshi Yokoi; Y Kawaguchi; Tetsuya Kamataki
Occurrence of autoantibody to protein disulfide isomerase in rats with xenobiotic-induced hepatitis.
The Journal of toxicological sciences 1994;19(3):155-61.
1994: E Kashiyama; Tsuyoshi Yokoi; T Todaka; M Odomi; Tetsuya Kamataki
Chiral inversion of drug: role of intestinal bacteria in the stereoselective sulphoxide reduction of flosequinan.
Biochemical pharmacology 1994;48(2):237-43.
1994: Y Yanagawa; M Sawada; T Deguchi; F J Gonzalez; Tetsuya Kamataki
Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Cancer research 1994;54(13):3422-7.
1994: Tsuyoshi Yokoi; S Nagayama; R Kajiwara; Y Kawaguchi; Tetsuya Kamataki
Effects of cyclosporin-A and D-penicillamine on the development of hepatitis and the production of antibody to protein disulfide isomerase in LEC rats.
Research communications in molecular pathology and pharmacology 1994;85(1):73-81.
1994: Miki Nakajima; Tsuyoshi Yokoi; M Mizutani; S Shin; F F Kadlubar; Tetsuya Kamataki
Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1994;3(5):413-21.
1994: E Kashiyama; Tsuyoshi Yokoi; K Itoh; S Itoh; M Odomi; Tetsuya Kamataki
Stereoselective S-oxidation of flosequinan sulfide by rat hepatic flavin-containing monooxygenase 1A1 expressed in yeast.
Biochemical pharmacology 1994;47(8):1357-63.
1994: E Kashiyama; T Todaka; M Odomi; Y Tanokura; D B Johnson; Tsuyoshi Yokoi; Tetsuya Kamataki; T Shimizu
Stereoselective pharmacokinetics and interconversions of flosequinan enantiomers containing chiral sulphoxide in rat.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(4):369-77.
1994: H Nakura; S Itoh; H Kusano; H Ishizone; Tetsuya Kamataki
Activities of drug-metabolizing enzymes in the liver of Suncus murinus: possible lack of N-acetyltransferase activity in liver cytosol.
Pharmacology 1994;48(3):201-4.
1994: T Sakuma; M Takai; Tsuyoshi Yokoi; Tetsuya Kamataki
Molecular cloning and sequence analysis of hamster CYP2E1.
Biochimica et biophysica acta 1994;1217(2):229-31.
1994: T Sakuma; K Masaki; S Itoh; Tsuyoshi Yokoi; Tetsuya Kamataki
Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs.
Molecular pharmacology 1994;45(2):228-36.
1993: H Hashimoto; K Toide; R Kitamura; M Fujita; S Tagawa; S Itoh; Tetsuya Kamataki
Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.
European journal of biochemistry / FEBS 1993;218(2):585-95.
1993: T Mori; R Kitamura; S Imaoka; Y Funae; T Matsubara; Tetsuya Kamataki
Increased CYP1A2 content and capacity to activate Glu-P-1 and Trp-P-2 in liver microsomes of scorbutic ODS rats.
Carcinogenesis 1993;14(12):2471-5.
1993: Tsuyoshi Yokoi; S Nagayama; R Kajiwara; Y Kawaguchi; R Horiuchi; Tetsuya Kamataki
Identification of protein disulfide isomerase and calreticulin as autoimmune antigens in LEC strain of rats.
Biochimica et biophysica acta 1993;1158(3):339-44.
1993: Yuko Okajima; Noriyuki Inaba; I Fukazawa; Y Ota; Y Hirai; N Sato; G Yamamoto; K Itahashi; Mitsukazu Kitada; Tetsuya Kamataki
Immunohistochemical and immunoelectron microscopic study of cytochrome P-450 of human fetal livers (P-450HFLa): implications for an onco-feto-placental enzyme.
Asia-Oceania journal of obstetrics and gynaecology / AOFOG 1993;19(3):329-41.
1993: M Komori; R Kitamura; H Fukuta; H Inoue; H Baba; K Yoshikawa; Tetsuya Kamataki
Transgenic Drosophila carrying mammalian cytochrome P-4501A1: an application to toxicology testing.
Carcinogenesis 1993;14(8):1683-8.
1993: S Itoh; S Tagawa; M Sawada; Tetsuya Kamataki
High susceptibility to aflatoxin B1 and benzo[a]pyrene of BALB3T3 A31-1-1 cells expressing monkey CYP1A1.
The Journal of toxicological sciences 1993;18(3):207-10.
1993: S Itoh; Tetsuya Kamataki
Human Ah receptor cDNA: analysis for highly conserved sequences.
Nucleic acids research 1993;21(15):3578.
1993: K Itoh; T Kimura; Tsuyoshi Yokoi; S Itoh; Tetsuya Kamataki
Rat liver flavin-containing monooxygenase (FMO): cDNA cloning and expression in yeast.
Biochimica et biophysica acta 1993;1173(2):165-71.
1993: M Sawada; R Kitamura; T Norose; M Kitada; K Itahashi; Tetsuya Kamataki
Metabolic activation of aflatoxin B1 by human placental microsomes.
The Journal of toxicological sciences 1993;18(2):129-32.
1993: M Narita; E Nagai; H Hagiwara; M Aburada; Tsuyoshi Yokoi; Tetsuya Kamataki
Inhibition of beta-glucuronidase by natural glucuronides of kampo medicines using glucuronide of SN-38 (7-ethyl-10-hydroxycamptothecin) as a substrate.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(1):5-10.
1993: M Sawada; R Kitamura; S Ohgiya; Tetsuya Kamataki
Stable expression of guinea pig NADPH-cytochrome P450 reductase and monkey P4501A1 cDNAs in Chinese hamster cells: establishment of cell lines highly sensitive to aflatoxin B [corrected].
Archives of biochemistry and biophysics 1993;300(1):164-8.
1992: M Komori; O Kikuchi; T Sakuma; J Funaki; Mitsukazu Kitada; Tetsuya Kamataki
Molecular cloning of monkey liver cytochrome P-450 cDNAs: similarity of the primary sequences to human cytochromes P-450.
Biochimica et biophysica acta 1992;1171(2):141-6.
1992: Mitsukazu Kitada; T Kato; Shigeru Ohmori; Tetsuya Kamataki; K Itahashi; F P Guengerich; T Rikihisa; Y Kanakubo
Immunochemical characterization and toxicological significance of P-450HFLb purified from human fetal livers.
Biochimica et biophysica acta 1992;1117(3):301-5.
1992: Tetsuya Kamataki; M Kitada; M Komori; Tsuyoshi Yokoi; R Kitamura
Human fetal liver cytochrome P-450: capacity to form genotoxic metabolites.
The Tohoku journal of experimental medicine 1992;168(2):89-95.
1992: H Fukuta; H Ohi; T Uchida; M Komori; Mitsukazu Kitada; Tetsuya Kamataki
Toxicological significance of dog liver cytochrome P-450: examination with the enzyme expressed in Saccharomyces cerevisiae using recombinant expression plasmid.
Mutation research 1992;269(1):97-105.
1992: H Nakura; S Itoh; H Kusano; H Ishizone; S Imaoka; Y Funae; T Yokoi; Tetsuya Kamataki
Decrease in the content of cytochrome P450IIE by fasting in liver microsomes of house musk shrew (Suncus murinus).
Biochemical pharmacology 1992;43(9):1907-10.
1992: M Komori; O Kikuchi; Mitsukazu Kitada; Tetsuya Kamataki
Molecular cloning of monkey P450 1A1 cDNA and expression in yeast.
Biochimica et biophysica acta 1992;1131(1):23-9.
1992: T Yanagimoto; S Itoh; D Muller-Enoch; Tetsuya Kamataki
Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone.
Biochimica et biophysica acta 1992;1130(3):329-32.
1992: S Itoh; T Yanagimoto; S Tagawa; H Hashimoto; R Kitamura; Y Nakajima; T Okochi; S Fujimoto; J Uchino; Tetsuya Kamataki
Genomic organization of human fetal specific P-450IIIA7 (cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5' flanking region.
Biochimica et biophysica acta 1992;1130(2):133-8.
1992: K Ubukata; H Ohi; Mitsukazu Kitada; Tetsuya Kamataki
A new form of cytochrome P-450 responsible for mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline in human livers.
Cancer research 1992;52(4):758-63.
1992: T Mori; R Kitamura; S Imaoka; Y Funae; Mitsukazu Kitada; Tetsuya Kamataki
Examination for lipid peroxidation in liver microsomes of guinea pigs as a causal factor in the decrease in the content of cytochrome P-450 due to ascorbic acid deficiency.
Research communications in chemical pathology and pharmacology 1992;75(2):209-19.
1992: R Kitamura; K Sato; M Sawada; S Itoh; Mitsukazu Kitada; M Komori; Tetsuya Kamataki
Stable expression of cytochrome P450IIIA7 cDNA in human breast cancer cell line MCF-7 and its application to cytotoxicity testing.
Archives of biochemistry and biophysics 1992;292(1):136-40.
1992: M Sawada; R Kitamura; Tetsuya Kamataki
Stable expression of monkey cytochrome P-450IA1 cDNA in Chinese hamster CHL cells and its application for detection of mutagenicity of aflatoxin B1.
Mutation research 1992;265(1):23-9.
1991: M Kashiwada; Mitsukazu Kitada; T Shimada; K Itahashi; K Sato; Tetsuya Kamataki
Purification and characterization of acidic form of glutathione S-transferase in human fetal livers: high similarity to placental form.
Journal of biochemistry 1991;110(5):743-7.
1991: S Nagayama; R Kitamura; T Yokoi; Y Kawaguchi; N Kasai; N Takeichi; H Kobayashi; Tetsuya Kamataki
Occurrence of autoimmune antibodies to liver microsomal proteins in association with fulminant hepatitis in the LEC strain of rats.
Biochemical and biophysical research communications 1991;179(2):1134-40.
1991: T Mori; Mitsukazu Kitada; S Imaoka; Y Funae; Tetsuya Kamataki
The in vitro effects of lipid peroxidation on the content of individual forms of cytochrome P-450 in liver microsomes of guinea-pigs.
Pharmacological research : the official journal of the Italian Pharmacological Society 1991;24(2):143-8.
1991: H Nakura; H Ohi; T Miura; T Fujiwara; H Ishizone; T Yokoi; Mitsukazu Kitada; Tetsuya Kamataki
Formation of an antibacterial metabolite from a new macrolide compound 23-O-benzyl-5-mycaminosyl-tylonolide (TMC-101), by a hepatic microsomal drug-metabolizing enzyme system.
Journal of pharmacobio-dynamics 1991;14(7):377-83.
1991: Mitsukazu Kitada; M Taneda; K Itahashi; Tetsuya Kamataki
Four forms of cytochrome P-450 in human fetal liver: purification and their capacity to activate promutagens.
Japanese journal of cancer research : Gann 1991;82(4):426-32.
1991: Tetsuya Kamataki; M Kitada; M Komori
Molecular toxicology on cytochrome P-450 in human fetal livers.
The Journal of toxicological sciences 1991;16 Suppl 1():107-16.
1990: T Uchida; M Komori; Mitsukazu Kitada; Tetsuya Kamataki
Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs.
Molecular pharmacology 1990;38(5):644-51.
1990: Mitsukazu Kitada; M Taneda; K Ohta; K Nagashima; K Itahashi; Tetsuya Kamataki
Metabolic activation of aflatoxin B1 and 2-amino-3-methylimidazo[4,5-f]-quinoline by human adult and fetal livers.
Cancer research 1990;50(9):2641-5.
1989: T Miura; M Iwasaki; M Komori; H Ohi; Mitsukazu Kitada; H Mitsui; Tetsuya Kamataki
Decrease in a constitutive form of cytochrome P-450 by macrolide antibiotics.
The Journal of antimicrobial chemotherapy 1989;24(4):551-9.
1989: Mitsukazu Kitada; M Taneda; H Ohi; M Komori; K Itahashi; M Nagao; Tetsuya Kamataki
Mutagenic activation of aflatoxin B1 by P-450 HFLa in human fetal livers.
Mutation research 1989;227(1):53-8.
1989: M Komori; K Nishio; T Fujitani; H Ohi; Mitsukazu Kitada; S Mima; K Itahashi; Tetsuya Kamataki
Isolation of a new human fetal liver cytochrome P450 cDNA clone: evidence for expression of a limited number of forms of cytochrome P450 in human fetal livers.
Archives of biochemistry and biophysics 1989;272(1):219-25.
1989: K Ohta; Mitsukazu Kitada; T Hashizume; M Komori; H Ohi; Tetsuya Kamataki
Purification of cytochrome P-450 from polychlorinated biphenyl-treated crab-eating monkeys: high homology to a form of human cytochrome P-450.
Biochimica et biophysica acta 1989;996(1-2):142-5.
1989: Mitsukazu Kitada; K Tsukidate; J Takeuchi; M Taneda; M Komori; H Ohi; K Itahashi; Tetsuya Kamataki
Immunochemical studies for the presence of P-450 HFLa, a form of cytochrome P-450 in human fetal livers in human hepatocellular carcinoma cells.
Journal of pharmacobio-dynamics 1989;12(6):341-4.
1989: T Miura; H Shimada; H Ohi; M Komori; T Kodama; Tetsuya Kamataki
Interspecies homology of cytochrome P-450: inhibition by anti-P-450-male antibodies of testosterone hydroxylases in liver microsomes from various animal species including man.
Japanese journal of pharmacology 1989;49(3):365-74.
1989: Tetsuya Kamataki; Mitsukazu Kitada; M Komori; N Inaba
[Resistance to anticancer drugs in relation to cytochrome P-450].
Gan to kagaku ryoho. Cancer & chemotherapy 1989;16(3 Pt 2):605-10.
1989: M Komori; K Nishio; H Ohi; Mitsukazu Kitada; Tetsuya Kamataki
Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450.
Journal of biochemistry 1989;105(2):161-3.
1989: Mitsukazu Kitada; M Komori; H Ohi; S Imaoka; Y Funae; Tetsuya Kamataki
Form-specific degradation of cytochrome P-450 by lipid peroxidation in rat liver microsomes.
Research communications in chemical pathology and pharmacology 1989;63(2):175-88.
1989: H Ohi; M Iwasaki; M Komori; T Miura; Mitsukazu Kitada; S Hayashi; Tetsuya Kamataki
Effects of serum testosterone level with buserelin on the activities of drug and testosterone hydroxylase and on the content of a male-specific form of cytochrome P-450 in male rats.
Biochemical pharmacology 1989;38(3):535-8.
1989: M Komori; H Shimada; T Miura; Tetsuya Kamataki
Interspecies homology of liver microsomal cytochrome P-450. A form of dog cytochrome P-450 (P-450-D1) crossreactive with antibodies to rat P-450-male.
Biochemical pharmacology 1989;38(2):235-40.
1989: H Ohi; S Toratani; M Komori; T Miura; Mitsukazu Kitada; Tetsuya Kamataki
Comparative study of cytochrome P-450 in liver microsomes. A form of monkey cytochrome P-450, P-450-MK1, immunochemically cross-reactive with antibodies to rat P-450-male.
Biochemical pharmacology 1989;38(2):361-5.
1989: K Ohta; M Motoya; M Komori; T Miura; Mitsukazu Kitada; Tetsuya Kamataki
A novel form of cytochrome P-450 in beagle dogs. P-450-D3 is a low spin form of cytochrome P-450 but with catalytic and structural properties similar to P-450d.
Biochemical pharmacology 1989;38(1):91-6.
1988: M Komori; T Hashizume; H Ohi; T Miura; Mitsukazu Kitada; K Nagashima; Tetsuya Kamataki
Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization.
Journal of biochemistry 1988;104(6):912-6.
1988: Mitsukazu Kitada; N Igoshi; Tetsuya Kamataki; K Itahashi; T Rikihisa; Y Kanakubo
The proteins immunochemically related to P-450 HFLa, a major form of cytochrome P-450 in human fetal livers, are present in liver microsomes from various animal species.
Research communications in chemical pathology and pharmacology 1988;62(1):31-40.
1988: Mitsukazu Kitada; N Igoshi; Tetsuya Kamataki; K Itahashi; S Imaoka; M Komori; Y Funae; T Rikihisa; Y Kanakubo
Immunochemical similarity of P-450 HFLa, a form of cytochrome P-450 in human fetal livers, to a form of rat liver cytochrome P-450 inducible by macrolide antibiotics.
Archives of biochemistry and biophysics 1988;264(1):61-6.
1988: Tetsuya Kamataki; M Komori; M Iwasaki; H Ohi; Mitsukazu Kitada; T Miura; K Ono
Effects of muroctasin on the activities of drug metabolizing enzymes in liver microsomes of rats.
Arzneimittel-Forschung 1988;38(7A):1019-22.
1988: T Miura; M Komori; M Iwasaki; K Kurozumi; K Ohta; S Ohmori; Mitsukazu Kitada; Tetsuya Kamataki
Sex-related difference in oxidative metabolism of testosterone and erythromycin by hamster liver microsomes.
FEBS letters 1988;231(1):183-6.
1987: Mitsukazu Kitada; Tetsuya Kamataki; K Itahashi; T Rikihisa; Y Kanakubo
P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate.
The Journal of biological chemistry 1987;262(28):13534-7.
1987: Mitsukazu Kitada; Tetsuya Kamataki; K Itahashi; T Rikihisa; Y Kanakubo
Significance of cytochrome P-450 (P-450 HFLa) of human fetal livers in the steroid and drug oxidations.
Biochemical pharmacology 1987;36(4):453-6.
1985: Mitsukazu Kitada; Tetsuya Kamataki; K Itahashi; T Rikihisa; R Kato; Y Kanakubo
Immunochemical examinations of cytochrome P-450 in various tissues of human fetuses using antibodies to human fetal cytochrome P-450, P-450 HFLa.
Biochemical and biophysical research communications 1985;131(3):1154-9.
1985: Mitsukazu Kitada; Tetsuya Kamataki; K Itahashi; T Rikihisa; R Kato; Y Kanakubo
Purification and properties of cytochrome P-450 from homogenates of human fetal livers.
Archives of biochemistry and biophysics 1985;241(1):275-80.