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Alexander Kamb

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TOP 3
Alexander Kamb; Susan Wee; Christoph Lengauer
Why is cancer drug discovery so difficult?
Alexander Kamb
What's wrong with our cancer models?
Michael Pierce; Chunwei Wang; Mark Stump; Alexander Kamb
Overexpression of the beta-catenin binding domain of cadherin selectively kills colorectal cancer cells.

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All Publications

2007: Alexander Kamb; Susan Wee; Christoph Lengauer
Why is cancer drug discovery so difficult?
Nature reviews. Drug discovery 2007;6(2):115-20.
2005: Alexander Kamb
What's wrong with our cancer models?
Nature reviews. Drug discovery 2005;4(2):161-5.
2003: Michael Pierce; Chunwei Wang; Mark Stump; Alexander Kamb
Overexpression of the beta-catenin binding domain of cadherin selectively kills colorectal cancer cells.
International journal of cancer. Journal international du cancer 2003;107(2):229-37.
2003: Tanya Sandrock; Alexander Kamb
Non-traditional drug targets: high risk, high reward.
Current gene therapy 2003;3(5):395-404.
2003: Mark A Poritz; Sharon Malmstrom; Amy Schmitt; Kwang-Hee (Marianne) Kim; Ludmilla Zharkikh; Alexander Kamb; David H-F Teng
Isolation of a peptide inhibitor of human rhinovirus.
Virology 2003;313(1):170-83.
2003: Giordano Caponigro; Majid Abedi; Alexander Kamb
Functional analysis of expressed peptides that bind yeast STE proteins.
Journal of biotechnology 2003;103(3):213-25.
2003: Alexander Kamb
Mutation load, functional overlap, and synthetic lethality in the evolution and treatment of cancer.
Journal of theoretical biology 2003;223(2):205-13.
2003: Michael Pierce; Chunwei Wang; Matthew Rebentisch; Mark Endo; Mark Stump; Alexander Kamb
A high-throughput, homogeneous microplate assay for agents that kill mammalian tissue culture cells.
Journal of biomolecular screening 2003;8(3):283-91.
2003: Alexander Kamb
Consequences of nonadaptive alterations in cancer.
Molecular biology of the cell 2003;14(6):2201-5.
2003: Alexander Kamb
Universities could gain from backing biotech.
Nature 2003;422(6928):113.
2003: Robert W Sandrock; William Wheatley; E Drees; M Lualhati; Alexander Kamb; Giordano Caponigro
A genetic selection method for expression products that induce apoptosis in adherent mammalian cell lines.
Apoptosis : an international journal on programmed cell death 2003;8(2):209-19.
2003: Burt Richards; Jon Karpilow; Christine Dunn; Isaac Peterson; Andrew Maxfield; Ludmilla Zharkikh; Majid Abedi; Anthony Hurlburt; Joshua Hardman; Forrest Hsu; Wenhua Li; Matthew Rebentisch; Robert W Sandrock; Tanya Sandrock; Alexander Kamb; David H-F Teng
Genetic selection for modulators of a retinoic-acid-responsive reporter in human cells.
Genetics 2003;163(3):1047-60.
2002: William Wheatley; Sanghee Yoo; Michael Pierce; Matthew Rebentisch; Mark Endo; Isaac Peterson; Mark Stump; Ken McCormack; Miguel Garcia-Guzman; Alexander Kamb
Genetic selection for modulators of the MAP kinase and beta-catenin growth-control pathways in mammalian cells.
Biochemical genetics 2002;40(11-12):359-78.
2002: Robert W Sandrock; Isaac Peterson; Cameron Evans; William Wheatley; Alexander Kamb
Enhanced expression of exogenous genes from retroviruses using HIV2/Tat.
Journal of biotechnology 2002;97(1):41-50.
2002: Burt Richards; Ludmilla Zharkikh; Forrest Hsu; Christine Dunn; Alexander Kamb; David H-F Teng
Stable expression of Anthozoa fluorescent proteins in mammalian cells.
Cytometry 2002;48(2):106-12.
2002: Mark Stump; Leonardo Di Sera; Matthew Rebentisch; Mark Endo; Michael Pierce; Alexander Kamb
An automated system for screening retroviral expression constructs in microplate format.
Journal of biomolecular screening 2002;7(3):275-80.
2002: Tanya Sandrock; Mark A Poritz; Marianne Kim; Michael J Feldhaus; Bruce Roth; Giordano Caponigro; Alexander Kamb
Expression levels of transdominant peptides and proteins in Saccharomyces cerevisiae.
Yeast (Chichester, England) 2002;19(1):1-7.
2001: Tanya Sandrock; B Risley; B T Richards; Mark A Poritz; H A Austin; S Yoo; Kwang-Hee (Marianne) Kim; B Roth; K Repetny; Forrest Hsu; Mark Stump; David H-F Teng; Alexander Kamb
Exogenous peptide and protein expression levels using retroviral vectors in human cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(5):398-406.
2001: Robert W Sandrock; Jon Karpilow; Burt Richards; Andrew Maxfield; C Wang; R Risley; Matthew Rebentisch; B Drees; David H-F Teng; Giordano Caponigro; Alexander Kamb
Enrichment during transdominant genetic experiments using a flow sorter.
Cytometry 2001;45(2):87-95.
2001: Mark A Poritz; S Malmstrom; Kwang-Hee (Marianne) Kim; P J Rossmeissl; Alexander Kamb
Graded mode of transcriptional induction in yeast pheromone signalling revealed by single-cell analysis.
Yeast (Chichester, England) 2001;18(14):1331-8.
2001: David H-F Teng; Forrest Hsu; Isaac Peterson; K E Cardon; Giordano Caponigro; Alexander Kamb
Template selection during manipulation of complex mixtures by PCR.
BioTechniques 2001;30(4):868-72, 874, 876-7.
2001: Alexander Kamb; Giordano Caponigro
Peptide inhibitors expressed in vivo.
Current opinion in chemical biology 2001;5(1):74-7.
2001: Majid Abedi; Giordano Caponigro; J Shen; S Hansen; Tanya Sandrock; Alexander Kamb
Transcriptional transactivation by selected short random peptides attached to lexA-GFP fusion proteins.
BMC molecular biology 2001;2():10.
2000: Alexander Kamb; David H-F Teng
Transdominant genetics, peptide inhibitors and drug targets.
Current opinion in molecular therapeutics 2000;2(6):662-9.
2000: M J Feldhaus; M Lualhati; K Cardon; B Roth; Alexander Kamb
Oligonucleotide-conjugated beads for transdominant genetic experiments.
Nucleic acids research 2000;28(2):534-43.
1999: Burt Richards; Jon Karpilow; Christine Dunn; Ludmilla Zharkikh; Andrew Maxfield; Alexander Kamb; David H-F Teng
Creation of a stable human reporter cell line suitable for FACS-based, transdominant genetic selection.
Somatic cell and molecular genetics 1999;25(4):191-205.
1998: Giordano Caponigro; Majid Abedi; A P Hurlburt; Andrew Maxfield; W Judd; Alexander Kamb
Transdominant genetic analysis of a growth control pathway.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7508-13.
1998: Majid Abedi; Giordano Caponigro; Alexander Kamb
Green fluorescent protein as a scaffold for intracellular presentation of peptides.
Nucleic acids research 1998;26(2):623-30.
1998: Alexander Kamb
Cyclin-dependent kinase inhibitors and human cancer.
Current topics in microbiology and immunology 1998;227():139-48.
1996: Lisa A Cannon-Albright; Alexander Kamb; M Skolnick
A review of inherited predisposition to melanoma.
Seminars in oncology 1996;23(6):667-72.
1996: S Stone; P Dayananth; Alexander Kamb
Reversible, p16-mediated cell cycle arrest as protection from chemotherapy.
Cancer research 1996;56(14):3199-202.
1996: David Teng; R Bogden; J Mitchell; M Baumgard; R Bell; S Berry; T Davis; P C Ha; R Kehrer; S Jammulapati; Q Chen; Kenneth Offit; Mark H Skolnick; Sean V Tavtigian; Suresh C Jhanwar; B Swedlund; AK Wong; Alexander Kamb
Low incidence of BRCA2 mutations in breast carcinoma and other cancers.
Nature genetics 1996;13(2):241-4.
1996: Alexander Kamb; Susan L Neuhausen
The cancers of man and woman.
Trends in genetics : TIG 1996;12(5):198.
1996: Alexander Kamb
Human melanoma genetics.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1996;1(2):177-82.
1996: Sean V Tavtigian; Jacques Simard; Johanna M Rommens; Fergus J. Couch; D Shattuck-Eidens; Susan L Neuhausen; Sofia D Merajver; Steinunn Thorlacius; Kenneth Offit; D Stoppa-Lyonnet; Carole Belanger; R Bell; S Berry; R Bogden; Q Chen; T Davis; M Dumont; Cynthia Frye; T Hattier; S Jammulapati; T Janecki; P Jiang; R Kehrer; J F Leblanc; J T Mitchell; J McArthur-Morrison; K Nguyen; Y Peng; C Samson; M Schroeder; S C Snyder; L Steele; M Stringfellow; C Stroup; B Swedlund; J Swense; David Teng; A Thomas; T Tran; M Tranchant; J Weaver-Feldhaus; AK Wong; H Shizuya; J E Eyfjord; Lisa A Cannon-Albright; M Tranchant; Fernand Labrie; Mark H Skolnick; B Weber; Alexander Kamb; David E Goldgar
The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.
Nature genetics 1996;12(3):333-7.
1995: T Hattier; R Bell; Daniel Shaffer; S Stone; R S Phelps; Sean V Tavtigian; Mark H Skolnick; D Shattuck-Eidens; Alexander Kamb
Monitoring the efficacy of hybrid selection during positional cloning: the search for BRCA1.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(12):873-9.
1995: R S Phelps; R B Chadwick; M P Conrad; M N Kronick; Alexander Kamb
Efficient, automatic detection of heterozygous bases during large-scale DNA sequence screening.
BioTechniques 1995;19(6):984-9.
1995: P Jiang; S Stone; R Wagner; S Wang; P Dayananth; C A Kozak; B Wold; Alexander Kamb
Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes p16 (MTS1) and p15 (MTS2).
Journal of molecular evolution 1995;41(6):795-802.
1995: S Stone; P Dayananth; P Jiang; J M Weaver-Feldhaus; Sean V Tavtigian; Lisa A Cannon-Albright; Alexander Kamb
Genomic structure, expression and mutational analysis of the P15 (MTS2) gene.
Oncogene 1995;11(5):987-91.
1995: S Stone; P Jiang; P Dayananth; Sean V Tavtigian; H Katcher; D Parry; G Peters; Alexander Kamb
Complex structure and regulation of the P16 (MTS1) locus.
Cancer research 1995;55(14):2988-94.
1995: Nelleke A Gruis; Pieter A van der Velden; Lodewijk A Sandkuijl; D E Prins; J Weaver-Feldhaus; Alexander Kamb; Wilma Bergman; Rune R Frants
Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds.
Nature genetics 1995;10(3):351-3.
1995: Alexander Kamb
Cell-cycle regulators and cancer.
Trends in genetics : TIG 1995;11(4):136-40.
1995: Alexander Kamb; C Wang; A Thomas; B S DeHoff; F H Norris; K Richardson; Jasper Rine; Mark H Skolnick; PR Rosteck
Software trapping: a strategy for finding genes in large genomic regions.
Computers and biomedical research, an international journal 1995;28(2):140-53.
1994: Susan L Neuhausen; Jeff Swensen; Y Miki; Q Liu; Sean V Tavtigian; D Shattuck-Eidens; Alexander Kamb; M R Hobbs; J Gingrich; H Shizuya
A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1.
Human molecular genetics 1994;3(11):1919-26.
1994: Alexander Kamb; D Shattuck-Eidens; R Eeles; Q Liu; Nelleke A Gruis; W Ding; C Hussey; T Tran; Y Miki; J Weaver-Feldhaus
Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus.
Nature genetics 1994;8(1):23-6.
1994: Lisa A Cannon-Albright; David E Goldgar; Susan L Neuhausen; Nelleke A Gruis; D E Anderson; C M Lewis; M Jost; T D Tran; K Nyguen; Alexander Kamb
Localization of the 9p melanoma susceptibility locus (MLM) to a 2-cM region between D9S736 and D9S171.
Genomics 1994;23(1):265-8.
1994: Alexander Kamb; P Andrew Futreal; J Rosenthal; C Cochran; K D Harshman; Q Liu; R S Phelps; Sean V Tavtigian; T Tran; C Hussey
Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1.
Genomics 1994;23(1):163-7.
1994: J Weaver-Feldhaus; Nelleke A Gruis; Susan L Neuhausen; D Le Paslier; E Stockert; Mark H Skolnick; Alexander Kamb
Localization of a putative tumor suppressor gene by using homozygous deletions in melanomas.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7563-7.
1994: Alexander Kamb; Nelleke A Gruis; J Weaver-Feldhaus; Q Liu; K Harshman; Sean V Tavtigian; E Stockert; R S Day; Bruce E Johnson; Mark H Skolnick
A cell cycle regulator potentially involved in genesis of many tumor types.
Science (New York, N.Y.) 1994;264(5157):436-40.
1994: Mark H Skolnick; Lisa A Cannon-Albright; Alexander Kamb
Genetic predisposition to melanoma.
European journal of cancer (Oxford, England : 1990) 1994;30A(13):1991-5.
1994: Alexander Kamb
Role of a cell cycle regulator in hereditary and sporadic cancer.
Cold Spring Harbor symposia on quantitative biology 1994;59():39-47.