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Sumalee Kamchonwongpaisan

Research Profile

Chemicals & Drugs

Physiology

Geographic Areas

Bhutan

Concepts & Ideas

Genes & Molecular Sequences

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Publications

TOP 3
Yongyuth Yuthavong; Jirundon Yuvaniyama; Uthai Arwon; Emily Bongard; Susan A Charman; William N Charman; Penchit Chitnumsub; Pascal Fantauzzi; Sumalee Kamchonwongpaisan; Danielle N McLennan; Roonglawan Rattanajak; Bongkoch Tarnchompoo; Supannee Taweechai; Chawanee Thongphanchang; Jarunee Vanichtanankul; Tirayut Vilaivan; Livia Vivas; Karen L White; David Matthews
Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target.
Phurpa Wangchuk; Anthony C Willis; Paul A Keller; Stephen G Pyne; Sumalee Kamchonwongpaisan
Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia.
Jarunee Vanichtanankul; Tirayut Vilaivan; Yongyuth Yuthavong; Penchit Chitnumsub; Supannee Taweechai; Chayasith Uttamapinant; Sumalee Kamchonwongpaisan
Combined spatial limitation around residues 16 and 108 of Plasmodium falciparum dihydrofolate reductase explains resistance to cycloguanil.

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All Publications

2012: Yongyuth Yuthavong; Jirundon Yuvaniyama; Uthai Arwon; Emily Bongard; Susan A Charman; William N Charman; Penchit Chitnumsub; Pascal Fantauzzi; Sumalee Kamchonwongpaisan; Danielle N McLennan; Roonglawan Rattanajak; Bongkoch Tarnchompoo; Supannee Taweechai; Chawanee Thongphanchang; Jarunee Vanichtanankul; Tirayut Vilaivan; Livia Vivas; Karen L White; David Matthews
Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(42):16823-8.
2012: Phurpa Wangchuk; Anthony C Willis; Paul A Keller; Stephen G Pyne; Sumalee Kamchonwongpaisan
Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia.
Journal of ethnopharmacology 2012;143(1):310-3.
2012: Jarunee Vanichtanankul; Tirayut Vilaivan; Yongyuth Yuthavong; Penchit Chitnumsub; Supannee Taweechai; Chayasith Uttamapinant; Sumalee Kamchonwongpaisan
Combined spatial limitation around residues 16 and 108 of Plasmodium falciparum dihydrofolate reductase explains resistance to cycloguanil.
Antimicrobial agents and chemotherapy 2012;56(7):3928-35.
2012: Phurpa Wangchuk; Paul A Keller; Stephen G Pyne; Roonglawan Rattanajak; Thanapat Sastraruji; Malai Taweechotipatr; Aunchalee Tonsomboon; Sumalee Kamchonwongpaisan
Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa.
Natural product communications 2012;7(5):575-80.
2012: Voravuth Somsak; Somdet Srichairatanakool; Sumalee Kamchonwongpaisan; Yongyuth Yuthavong; Chairat Uthaipibull
Flow cytometric enumeration of Plasmodium berghei-infected red blood cells stained with SYBR Green I.
Acta tropica 2012;122(1):113-8.
2012: Thitima Maturos; Tawee Pogfay; Kiattimant Rodaree; Philip Shaw; Nattida Suwanakitti; Sastra Chaotheing; Kata Jaruwongrungsee; Apichai Jomphoak; Sumalee Kamchonwongpaisan; Anurat Wisitsoraat; Chayapat Wongsombat; Adisorn Tuantranont
Enhancement of DNA hybridization under acoustic streaming with three-piezoelectric-transducer system.
Lab on a chip 2012;12(1):133-8.
2011: Jarunee Vanichtanankul; Tirayut Vilaivan; Penchit Chitnumsub; Sumalee Kamchonwongpaisan; Supannee Taweechai; Jirundon Yuvaniyama; Yongyuth Yuthavong
Trypanosomal dihydrofolate reductase reveals natural antifolate resistance.
ACS chemical biology 2011;6(9):905-11.
2011: Phurpa Wangchuk; Paul A Keller; Stephen G Pyne; Roonglawan Rattanajak; Malai Taweechotipatr; Aunchalee Tonsomboon; Sumalee Kamchonwongpaisan
Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of phytochemicals and biological activities.
Journal of ethnopharmacology 2011;137(1):730-42.
2011: Voravuth Somsak; Somdet Srichairatanakool; Sumalee Kamchonwongpaisan; Yongyuth Yuthavong; Chairat Uthaipibull
Small-scale in vitro culture and purification of Plasmodium berghei for transfection experiment.
Molecular and biochemical parasitology 2011;177(2):156-9.
2011: Kiattimant Rodaree; Thitima Maturos; Sastra Chaotheing; Tawee Pogfay; Nattida Suwanakitti; Chayapat Wongsombat; Kata Jaruwongrungsee; Anurat Wisitsoraat; Sumalee Kamchonwongpaisan; Tanom Lomas; Adisorn Tuantranont
DNA hybridization enhancement using piezoelectric microagitation through a liquid coupling medium.
Lab on a chip 2011;11(6):1059-64.
2011: Voravuth Somsak; Somdet Srichairatanakool; Chairat Uthaipibull; Yongyuth Yuthavong; Parichat Prommana; Sumalee Kamchonwongpaisan
Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening.
Malaria journal 2011;10():291.
2011: Kanyanan Kritsiriwuthinan; Philip J Shaw; Chayaphat Wongsombat; Sastra Chaotheing; Porntip Chavalitshewinkoon-Petmitr; Sumalee Kamchonwongpaisan
Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridine.
Malaria journal 2011;10():242.
2011: Wachiraporn Tipsuwan; Somdet Srichairatanakool; Sumalee Kamchonwongpaisan; Yongyuth Yuthavong; Chairat Uthaipibull
Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model.
Malaria journal 2011;10():119.
2010: Phurpa Wangchuk; John B Bremner; Brian W Skelton; Allan H White; Roonglawan Rattanajak; Sumalee Kamchonwongpaisan
Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum.
Journal of ethnopharmacology 2010;130(3):559-62.
2010: Alexis Nzila; Matthias Rottmann; Penchit Chitnumsub; Stevens M Kiara; Sumalee Kamchonwongpaisan; Cherdsak Maneeruttanarungroj; Supannee Taweechai; Bryan K S Yeung; Anne Goh; Suresh B Lakshminarayana; Bin Zou; Josephine Wong; Ngai Ling Ma; Margaret Weaver; Thomas H Keller; Veronique Dartois; Sergio Wittlin; Reto Brun; Yongyuth Yuthavong; Thierry T Diagana
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.
Antimicrobial agents and chemotherapy 2010;54(6):2603-10.
2010: Phurpa Wangchuk; John B Bremner; Roonglawan Rattanajak; Sumalee Kamchonwongpaisan
Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha.
Phytotherapy research : PTR 2010;24(4):481-5.
2009: Elena R Lozovsky; Thanat Chookajorn; Kyle M Brown; Mallika Imwong; Philip J Shaw; Sumalee Kamchonwongpaisan; Daniel E Neafsey; Daniel M Weinreich; Daniel L Hartl
Stepwise acquisition of pyrimethamine resistance in the malaria parasite.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12025-30.
2009: Phornphimon Maitarad; Sumalee Kamchonwongpaisan; Jarunee Vanichtanankul; Tirayut Vilaivan; Yongyuth Yuthavong; Supot Hannongbua
Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases.
Journal of computer-aided molecular design 2009;23(4):241-52.
2009: Phornphimon Maitarad; Patchreenart Saparpakorn; Supot Hannongbua; Sumalee Kamchonwongpaisan; Bongkoch Tarnchompoo; Yongyuth Yuthavong
Particular interaction between pyrimethamine derivatives and quadruple mutant type dihydrofolate reductase of Plasmodium falciparum: CoMFA and quantum chemical calculations studies.
Journal of enzyme inhibition and medicinal chemistry 2009;24(2):471-9.
2009: Angela Cruz; Juliano Simões Toledo; Folusho Oludare Falade; Mônica Cristina Terrão; Sumalee Kamchonwongpaisan; Dennis E Kyle; Chairat Uthaipibull
Current treatment and drug discovery against Leishmania spp. and Plasmodium spp.: a review.
Current drug targets 2009;10(3):178-92.
2009: Tina Dasgupta; Penchit Chitnumsub; Sumalee Kamchonwongpaisan; Cherdsak Maneeruttanarungroj; Sara Elizabeth Nichols; Theresa M Lyons; Julian Tirado-Rives; William L Jorgensen; Yongyuth Yuthavong; Karen S Anderson
Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria.
ACS chemical biology 2009;4(1):29-40.
2008: Karthikeyan Ganesan; Napawan Ponmee; Lei Jiang; Joseph W Fowble; John White; Sumalee Kamchonwongpaisan; Yongyuth Yuthavong; Prapon Wilairat; Pradipsinh K Rathod
A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates.
PLoS pathogens 2008;4(11):e1000214.
2007: Philip J Shaw; Napawan Ponmee; Nitsara Karoonuthaisiri; Sumalee Kamchonwongpaisan; Yongyuth Yuthavong
Characterization of human malaria parasite Plasmodium falciparum eIF4E homologue and mRNA 5' cap status.
Molecular and biochemical parasitology 2007;155(2):146-55.
2007: Chawanee Thongpanchang; Supannee Taweechai; Sumalee Kamchonwongpaisan; Yongyuth Yuthavong; Yodhathai Thebtaranonth
Immobilization of malarial (Plasmodium falciparum) dihydrofolate reductase for the selection of tight-binding inhibitors from combinatorial library.
Analytical chemistry 2007;79(13):5006-12.
2007: Napawan Ponmee; Tatsanee Chuchue; Prapon Wilairat; Yongyuth Yuthavong; Sumalee Kamchonwongpaisan
Artemisinin effectiveness in erythrocytes is reduced by heme and heme-containing proteins.
Biochemical pharmacology 2007;74(1):153-60.
2007: Sumalee Kamchonwongpaisan; Jarunee Vanichtanankul; Supannee Taweechai; Penchit Chitnumsub; Yongyuth Yuthavong
The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase.
International journal for parasitology 2007;37(7):787-93.
2007: Patompon Wongtrakoongate; Napachanok Mongkoldhumrongkul; Suthidarak Chaijan; Sumalee Kamchonwongpaisan; Sumalee Tungpradabkul
Comparative proteomic profiles and the potential markers between Burkholderia pseudomallei and Burkholderia thailandensis.
Molecular and cellular probes 2007;21(2):81-91.
2006: Sasinee Bunyarataphan; Ubolsree Leartsakulpanich; Supannee Taweechai; Bongkoch Tarnchompoo; Sumalee Kamchonwongpaisan; Yongyuth Yuthavong
Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.
Antimicrobial agents and chemotherapy 2006;50(11):3631-7.
2006: Yongyuth Yuthavong; Sumalee Kamchonwongpaisan; Ubolsree Leartsakulpanich; Penchit Chitnumsub
Folate metabolism as a source of molecular targets for antimalarials.
Future microbiology 2006;1(1):113-25.
2005: Yongyuth Yuthavong; Jirundon Yuvaniyama; Penchit Chitnumsub; Jarunee Vanichtanankul; Sudsanguan Chusacultanachai; Bongkoch Tarnchompoo; Tirayut Vilaivan; Sumalee Kamchonwongpaisan
Malarial (Plasmodium falciparum) dihydrofolate reductase-thymidylate synthase: structural basis for antifolate resistance and development of effective inhibitors.
Parasitology 2005;130(Pt 3):249-59.
2005: Sumalee Kamchonwongpaisan; Jarunee Vanichtanankul; Bongkoch Tarnchompoo; Jirundon Yuvaniyama; Supannee Taweechai; Yongyuth Yuthavong
Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.
Analytical chemistry 2005;77(5):1222-7.
2005: Jerapan Krungkrai; Andrea Scozzafava; Sutarnthip Reungprapavut; Sudaratana R Krungkrai; Roonglawan Rattanajak; Sumalee Kamchonwongpaisan; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action?
Bioorganic & medicinal chemistry 2005;13(2):483-9.
2004: Penchit Chitnumsub; Jirundon Yuvaniyama; Jirundon Yavaniyama; Jarunee Vanichtanankul; Sumalee Kamchonwongpaisan; Malcolm D Walkinshaw; Yongyuth Yuthavong
Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 4):780-3.
2004: Sumalee Kamchonwongpaisan; Rachel Quarrell; Netnapa Charoensetakul; Rachel Ponsinet; Tirayut Vilaivan; Jarunee Vanichtanankul; Bongkoch Tarnchompoo; Worachart Sirawaraporn; Gordon Lowe; Yongyuth Yuthavong
Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.
Journal of medicinal chemistry 2004;47(3):673-80.
2004: Chawanee Sirichaiwat; Chakapong Intaraudom; Sumalee Kamchonwongpaisan; Jarunee Vanichtanankul; Yodhathai Thebtaranonth; Yongyuth Yuthavong
Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum.
Journal of medicinal chemistry 2004;47(2):345-54.
2003: Jirundon Yuvaniyama; Penchit Chitnumsub; Sumalee Kamchonwongpaisan; Jarunee Vanichtanankul; Worachart Sirawaraporn; Paul Taylor; Malcolm D Walkinshaw; Yongyuth Yuthavong
Insights into antifolate resistance from malarial DHFR-TS structures.
Nature structural biology 2003;10(5):357-65.
2003: Tirayut Vilaivan; Neungruthai Saesaengseerung; Deanpen Jarprung; Sumalee Kamchonwongpaisan; Worachart Sirawaraporn; Yongyuth Yuthavong
Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum.
Bioorganic & medicinal chemistry 2003;11(2):217-24.
2003: Jantanee Wattanarangsan; Sudsanguan Chusacultanachai; Jirundon Yuvaniyama; Sumalee Kamchonwongpaisan; Yongyuth Yuthavong
Effect of N-terminal truncation of Plasmodium falciparum dihydrofolate reductase on dihydrofolate reductase and thymidylate synthase activity.
Molecular and biochemical parasitology 2003;126(1):97-102.
2002: Worachart Sirawaraporn; Rachada Sirawaraporn; Suganya Yongkiettrakul; Amornpol Anuwatwora; Giulio Rastelli; Sumalee Kamchonwongpaisan; Yongyuth Yuthavong
Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding.
Molecular and biochemical parasitology 2002;121(2):185-93.
2002: Bongkoch Tarnchompoo; Chawanee Sirichaiwat; Worrapong Phupong; Chakapong Intaraudom; Worachart Sirawaraporn; Sumalee Kamchonwongpaisan; Jarunee Vanichtanankul; Yodhathai Thebtaranonth; Yongyuth Yuthavong
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.
Journal of medicinal chemistry 2002;45(6):1244-52.
2002: Prapairat Seephonkai; Masahiko Isaka; Prasat Kittakoop; Prasit Palittapongarnpim; Sumalee Kamchonwongpaisan; Morakot Tanticharoen; Yodhathai Thebtaranonth
Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050.
Planta medica 2002;68(1):45-8.
2001: S Ekthawatchai; Sumalee Kamchonwongpaisan; Palangpon Kongsaeree; Bongkoch Tarnchompoo; Yodhathai Thebtaranonth; Yongyuth Yuthavong
C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene.
Journal of medicinal chemistry 2001;44(26):4688-95.
2001: Amonlaya Jaturapat; Masahiko Isaka; Nigel Hywel-Jones; Y Lertwerawat; Sumalee Kamchonwongpaisan; Kanyawim Kirtikara; Morakot Tanticharoen; Yodhathai Thebtaranonth
Bioxanthracenes from the insect pathogenic fungus. Cordyceps pseudomilitaris BCC 1620. I. Taxonomy, fermentation, isolation and antimalarial activity.
The Journal of antibiotics 2001;54(1):29-35.
2000: C Nilanonta; Masahiko Isaka; Prasat Kittakoop; Prasit Palittapongarnpim; Sumalee Kamchonwongpaisan; D Pittayakhajonwut; Morakot Tanticharoen; Yodhathai Thebtaranonth
Antimycobacterial and antiplasmodial cyclodepsipeptides from the insect pathogenic fungus Paecilomyces tenuipes BCC 1614.
Planta medica 2000;66(8):756-8.
2000: Yongyuth Yuthavong; Tirayut Vilaivan; N Chareonsethakul; Sumalee Kamchonwongpaisan; Worachart Sirawaraporn; Rachel Quarrell; Gordon Lowe
Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum.
Journal of medicinal chemistry 2000;43(14):2738-44.
2000: J Charoenteeraboon; Sumalee Kamchonwongpaisan; Prapon Wilairat; Paiboon Vattanaviboon; Yongyuth Yuthavong
Inactivation of artemisinin by thalassemic erythrocytes.
Biochemical pharmacology 2000;59(11):1337-44.
2000: Giulio Rastelli; Worachart Sirawaraporn; P Sompornpisut; Tirayut Vilaivan; Sumalee Kamchonwongpaisan; Rachel Quarrell; Gordon Lowe; Yodhathai Thebtaranonth; Yongyuth Yuthavong
Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance.
Bioorganic & medicinal chemistry 2000;8(5):1117-28.