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Peter Backx

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Ashok Jadhav; Selliah C Kanthan; Andrew S Levy; Wenbin Liang; Peter C Papageorgiou; Ahmed Shoker; Peter H Backx; John Balsevich; Scott Heximer; Venkat Gopalakrishnan
Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes.
Minsuk Kim; Mathew J Platt; Susan E Quaggin; Susumu Seino; Tadao Shibasaki; Jeremy A Simpson; Peter H Backx; Daniel J Drucker
GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure.
Roxana Chis; Peter H Backx; Nicolas Bousette; Tetsuaki Miyake; Parveen Sharma; Aaron Wilson; Anthony O Gramolini
α-Crystallin B prevents apoptosis after H2O2 exposure in mouse neonatal cardiomyocytes.

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All Publications

2013: Ashok Jadhav; Selliah C Kanthan; Andrew S Levy; Wenbin Liang; Peter C Papageorgiou; Ahmed Shoker; Peter H Backx; John Balsevich; Scott Heximer; Venkat Gopalakrishnan
Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes.
The Journal of pharmacology and experimental therapeutics 2013;345(3):383-92.
2013: Minsuk Kim; Mathew J Platt; Susan E Quaggin; Susumu Seino; Tadao Shibasaki; Jeremy A Simpson; Peter H Backx; Daniel J Drucker
GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure.
Nature medicine 2013;19(5):567-75.
2012: Roxana Chis; Peter H Backx; Nicolas Bousette; Tetsuaki Miyake; Parveen Sharma; Aaron Wilson; Anthony O Gramolini
α-Crystallin B prevents apoptosis after H2O2 exposure in mouse neonatal cardiomyocytes.
American journal of physiology. Heart and circulatory physiology 2012;303(8):H967-78.
2012: Xue Wu; Jiani Yin; Peter H Backx; Peter Bayliss; Shengqing Gu; Jenny H Hong; Kyoung-Han Kim; Benjamin G Neel; Jeremy Simpson; Toshiyuki Araki
Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.
Molecular and cellular biology 2012;32(19):3872-90.
2012: Krishnakumar Nair; Roman Pekhletski; Elod Szabo; Peter H Backx; Melanie Care; Talha Farid; Louise Harris; Chantal Morel; Kumaraswamy Nanthakumar
Escape capture bigeminy: phenotypic marker of cardiac sodium channel voltage sensor mutation R222Q.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(10):1681-1688.e1.
2012: Peter H Backx
Could plugging the oxidation-mediated Ca2+ leak stem the tide of the atrial fibrillation epidemic?
Circulation research 2012;111(6):662-5.
2012: Norbert Degousee; Shafie Fazel; Gerd Geisslinger; Per-Johan Jakobsson; Armand Keating; Marina Korotkova; Ren-Ke Li; Thomas F Lindsay; Matthias Nahrendorf; Efrat Ofek; Sandra Pierre; Carlo Angioni; Denis Angoulvant; Peter H Backx; Jagdish Butany; Helmut Schmidt; Klaus Scholich; Jeremy Simpson; Eva Stefanski; Xing-Hua Wang; Barry B Rubin
Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction.
Circulation 2012;125(23):2904-13.
2012: Peter C Papageorgiou; Erik L Yeo; Peter H Backx; John S Floras
A new enzyme-linked immunosorbent assay recognizing both rat and human activated coagulation Factor XII (FXIIa).
Journal of immunological methods 2012;376(1-2):132-8.
2011: Sanja Beca; Brian K Panama; Roozbeh Aschars-Sobbi; Peter H Backx
Regulation of murine cardiac function by phosphodiesterases type 3 and 4.
Current opinion in pharmacology 2011;11(6):714-9.
2011: Rafael J Ramirez; Robert A Rose; Rajan Sah; Jie Liu; Peter H Backx
Intracellular [Na(+)] modulates synergy between Na(+)/Ca (2+) exchanger and L-type Ca (2+) current in cardiac excitation-contraction coupling during action potentials.
Basic research in cardiology 2011;106(6):967-77.
2011: Sanja Beca; S R Wayne Chen; Marco Conti; Gerrie P Farman; Peter B Helli; Peter P Jones; Vincent Manganiello; Donald H Maurice; Matthew A Movsesian; Jeremy A Simpson; Xixi Tian; Lindsay S Wilson; Dongling Zhao; Faiyaz Ahmad; Peter H Backx
Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current.
Circulation research 2011;109(9):1024-30.
2011: Robert A Rose; Michael Sellan; Jeremy A Simpson; Joerg Striessnig; Dongling Zhao; Carlo Cifelli; Mark Davis; Scott P Heximer; Farzad Izaddoustdar; Peter P Liu; Moniba Markhani; Geoffrey G Murphy; Brian K Panama; Peter H Backx
Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation.
Circulation. Arrhythmia and electrophysiology 2011;4(5):733-42.
2011: A Russell Tupling; Chris Vigna; Gopal J Babu; Peter H Backx; Darin Bloemberg; Eric Bombardier; Subash C Gupta; Dawar Hussain; David H MacLennan; Muthu Periasamy; Joe Quadrilatero; Maria G Trivieri; Anthony O Gramolini
Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice.
American journal of physiology. Cell physiology 2011;301(4):C841-9.
2011: Tami A Martino; Nazneen Tata; Jeremy A Simpson; Rachel Vanderlaan; Fayez Dawood; M Golam Kabir; Neelam Khaper; Carlo Cifelli; Peter Podobed; Peter P Liu; Mansoor Husain; Scott Heximer; Peter H Backx; Michael J Sole
The primary benefits of angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy.
Journal of the American College of Cardiology 2011;57(20):2020-8.
2011: Jing Li; Wanli Xuan; Ran Yan; Michael B Tropak; Emilie Jean-St-Michel; Wenbin Liang; Rachel Gladstone; Peter H Backx; Rajesh K Kharbanda; Andrew N Redington
Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of β-catenin.
Clinical science (London, England : 1979) 2011;120(10):451-62.
2011: Peter H Backx
Serving up the ping-pong mechanisms for biventricular ventricular tachycardia.
Heart rhythm : the official journal of the Heart Rhythm Society 2011;8(4):606-7.
2011: Jie Liu; Kyoung-Han Kim; Barry London; Michael J Morales; Peter H Backx
Dissection of the voltage-activated potassium outward currents in adult mouse ventricular myocytes: I(to,f), I(to,s), I(K,slow1), I(K,slow2), and I(ss).
Basic research in cardiology 2011;106(2):189-204.
2011: Erin E Mueller; Abdul Momen; Stéphane Massé; Yu-Qing Zhou; Jie Liu; Peter H Backx; R Mark Henkelman; Kumaraswamy Nanthakumar; Duncan J Stewart; Mansoor Husain
Electrical remodelling precedes heart failure in an endothelin-1-induced model of cardiomyopathy.
Cardiovascular research 2011;89(3):623-33.
2010: Elias Q Scherer; Jingli Yang; Martin Canis; Katrin Reimann; Karolina Ivanov; Christian D Diehl; Peter H Backx; W Gil Wier; Sebastian Strieth; Philine Wangemann; Julia Voigtlaender-Bolz; Darcy Lidington; Steffen-Sebastian Bolz
Tumor necrosis factor-α enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling.
Stroke; a journal of cerebral circulation 2010;41(11):2618-24.
2010: Nicolas Bousette; Shaan Chugh; Vincent Fong; Ruth Isserlin; Kyoung-Han Kim; Allen Volchuk; Peter H Backx; Peter Liu; Thomas Kislinger; David H MacLennan; Andrew Emili; Anthony O Gramolini
Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(43):18481-6.
2009: Nazzareno D'Avanzo; Roman Pekhletski; Peter H Backx
P-loop residues critical for selectivity in K channels fail to confer selectivity to rabbit HCN4 channels.
PloS one 2009;4(11):e7712.
2008: Robert A Rose; Huijie Jiang; Xinghua Wang; Simone Helke; James N Tsoporis; Nanling Gong; Stephanie C J Keating; Thomas G Parker; Peter H Backx; Armand Keating
Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro.
Stem cells (Dayton, Ohio) 2008;26(11):2884-92.
2008: Kiwon Ban; Andrew J Cooper; Sara Samuel; Adil Bhatti; Mikin Patel; Seigo Izumo; Josef M Penninger; Peter H Backx; Gavin Y Oudit; Robert G Tsushima
Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning.
Circulation research 2008;103(6):643-53.
2008: Carlo Cifelli; Robert A Rose; Hangjun Zhang; Julia Voigtlaender-Bolz; Steffen-Sebastian Bolz; Peter H Backx; Scott P Heximer
RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node.
Circulation research 2008;103(5):527-35.
2008: Gavin Y Oudit; Zamaneh Kassiri; Joyce Zhou; Qiao C Liu; Peter P Liu; Peter H Backx; Fayez Dawood; Michael A Crackower; James W Scholey; Josef M Penninger
Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress.
Cardiovascular research 2008;78(3):505-14.
2008: Tami Martino; Gavin Y Oudit; Andrew Herzenberg; Nazneen Tata; Margaret M Koletar; Golam M Kabir; Denise D Belsham; Peter H Backx; Martin R Ralph; Michael J Sole
Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;294(5):R1675-83.
2008: Yonghong Zhu; Anthony O Gramolini; Mark A Walsh; Yu-Qing Zhou; Cameron Slorach; Mark K Friedberg; Jun K Takeuchi; Hui Sun; R Mark Henkelman; Peter H Backx; Andrew N Redington; David H MacLennan; Benoit G Bruneau
Tbx5-dependent pathway regulating diastolic function in congenital heart disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(14):5519-24.
2008: Anthony O Gramolini; Thomas Kislinger; Rasoul Alikhani-Koopaei; Vincent Fong; Natalie J Thompson; Ruth Isserlin; Parveen Sharma; Gavin Y Oudit; Maria G Trivieri; Ailís Fagan; Anitha Kannan; Desmond G Higgins; Hendrik Huedig; George Hess; Sara Arab; Jonathan G Seidman; Christine E Seidman; Brendan Frey; Marc David Perry; Peter H Backx; Peter P Liu; David H MacLennan; Andrew Emili
Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses.
Molecular & cellular proteomics : MCP 2008;7(3):519-33.
2008: Kyoung-Han Kim; Gavin Y Oudit; Peter H Backx
Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent pathway.
The Journal of pharmacology and experimental therapeutics 2008;324(1):160-9.
2007: Robert A Rose; golam kabir; Peter H Backx
Altered heart rate and sinoatrial node function in mice lacking the cAMP regulator phosphoinositide 3-kinase-gamma.
Circulation research 2007;101(12):1274-82.
2007: Benoit-Gilles Kerfant; Dongling Zhao; Ilka Lorenzen-Schmidt; Lindsay S Wilson; Shitian Cai; S R Wayne Chen; Donald H Maurice; Peter H Backx
PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes.
Circulation research 2007;101(4):400-8.
2007: Denise W Wong; Gavin Y Oudit; Heather Reich; Zamaneh Kassiri; Joyce Zhou; Qiao C Liu; Peter H Backx; Josef M Penninger; Andrew Herzenberg; James W Scholey
Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury.
The American journal of pathology 2007;171(2):438-51.
2007: Gavin Y Oudit; Zamaneh Kassiri; Mikin P Patel; Mark Chappell; Jagdish Butany; Peter H Backx; Robert G Tsushima; James W Scholey; Rama Khokha; Josef M Penninger
Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice.
Cardiovascular research 2007;75(1):29-39.
2007: Younes Anini; Angelo Izzo; Gavin Y Oudit; Peter H Backx; Patricia L Brubaker
Role of phosphatidylinositol-3 kinase-gamma in the actions of glucagon-like peptide-2 on the murine small intestine.
American journal of physiology. Endocrinology and metabolism 2007;292(6):E1599-606.
2007: Tami Martino; Nazneen Tata; Denise D Belsham; Jennifer Chalmers; Marty Straume; Paul Lee; Horia Pribiag; Neelam Khaper; Peter P Liu; Fayez Dawood; Peter H Backx; Martin R Ralph; Michael J Sole
Disturbed diurnal rhythm alters gene expression and exacerbates cardiovascular disease with rescue by resynchronization.
Hypertension 2007;49(5):1104-13.
2007: Gavin Y Oudit; Victoria Korley; Peter H Backx; Paul Dorian
Lithium-induced sinus node disease at therapeutic concentrations: linking lithium-induced blockade of sodium channels to impaired pacemaker activity.
The Canadian journal of cardiology 2007;23(3):229-32.
2006: Nanling Gong; Ilona Bodi; Carsten Zobel; Arnold Schwartz; Jeffery D Molkentin; Peter H Backx
Calcineurin increases cardiac transient outward K+ currents via transcriptional up-regulation of Kv4.2 channel subunits.
The Journal of biological chemistry 2006;281(50):38498-506.
2006: Benoit-Gilles Kerfant; Robert A Rose; Hui Sun; Peter H Backx
Phosphoinositide 3-kinase gamma regulates cardiac contractility by locally controlling cyclic adenosine monophosphate levels.
Trends in cardiovascular medicine 2006;16(7):250-6.
2006: Li-Xin Li; Patrick E MacDonald; Diane S Ahn; Gavin Y Oudit; Peter H Backx; Patricia L Brubaker
Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1.
Endocrinology 2006;147(7):3318-25.
2006: Hui Sun; Benoit-Gilles Kerfant; Dongling Zhao; Maria G Trivieri; Gavin Y Oudit; Josef M Penninger; Peter H Backx
Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling.
Circulation research 2006;98(11):1390-7.
2006: Gavin Y Oudit; Andrew Herzenberg; Zamaneh Kassiri; Denise Wong; Heather Reich; Rama Khokha; Michael A Crackower; Peter H Backx; Josef M Penninger; James W Scholey
Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis.
The American journal of pathology 2006;168(6):1808-20.
2006: Gavin Y Oudit; Maria G Trivieri; Neelam Khaper; Peter P Liu; Peter H Backx
Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy.
Journal of molecular medicine (Berlin, Germany) 2006;84(5):349-64.
2006: Maria G Trivieri; Gavin Y Oudit; Rajan Sah; Benoit-Gilles Kerfant; Hui Sun; Anthony O Gramolini; Yan Pan; Alan D Wickenden; Walburga Croteau; Gabriella Morreale de Escobar; Roman Pekhletski; Donald L St Germain; David H MacLennan; Peter H Backx
Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):6043-8.
2006: Jian Xu; Nanling Gong; Ilona Bodi; Bruce Aronow; Peter H Backx; Jeffery D Molkentin
Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice.
The Journal of biological chemistry 2006;281(14):9152-62.
2006: Anthony O Gramolini; Maria G Trivieri; Gavin Y Oudit; Thomas Kislinger; Wenping Li; Mikin M Patel; Andrew Emili; Evangelia G Kranias; Peter H Backx; David H MacLennan
Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2446-51.
2005: Kwokyin Hui; Peter Gardzinski; Hong-Shuo Sun; Peter H Backx; Zhong-Ping Feng
Permeable ions differentially affect gating kinetics and unitary conductance of L-type calcium channels.
Biochemical and biophysical research communications 2005;338(2):783-92.
2005: Nicholas Joza; Gavin Y Oudit; Doris Brown; Paule Bénit; Zamaneh Kassiri; Nicola Vahsen; Loralyn Benoit; Mikin M Patel; Karin Nowikovsky; Anne Vassault; Peter H Backx; Teiji Wada; Guido Kroemer; Pierre Rustin; Josef M Penninger
Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy.
Molecular and cellular biology 2005;25(23):10261-72.
2005: Danny L Costantini; Eric P Arruda; Pooja Agarwal; Kyoung-Han Kim; Yonghong Zhu; Wei Zhu; Mélanie Lebel; Chi Wa Cheng; Chong Y Park; Stephanie A Pierce; Alejandra Guerchicoff; Guido D Pollevick; Toby Y Chan; golam kabir; Shuk Han Cheng; Mansoor Husain; Charles Antzelevitch; Deepak Srivastava; Gil J Gross; Chi-Chung Hui; Peter H Backx; Benoit G Bruneau
The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.
Cell 2005;123(2):347-58.
2005: Zamaneh Kassiri; Gavin Y Oudit; Otto H Sanchez; Fayez Dawood; Fazilat F Mohammed; Robert K Nuttall; Dylan R Edwards; Peter P Liu; Peter H Backx; Rama Khokha
Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice.
Circulation research 2005;97(4):380-90.
2005: Benoit-Gilles Kerfant; Dominica Gidrewicz; Hui Sun; Gavin Y Oudit; Josef M Penninger; Peter H Backx
Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice.
Circulation research 2005;96(10):1079-86.
2005: Nazzareno D'Avanzo; Hee Cheol Cho; Illya Tolokh; Roman Pekhletski; Igor Tolokh; Chris Gray; Saul Goldman; Peter H Backx
Conduction through the inward rectifier potassium channel, Kir2.1, is increased by negatively charged extracellular residues.
The Journal of general physiology 2005;125(5):493-503.
2005: Igor S Tolokh; Illya I Tolokh; Hee Cheol Cho; Nazzareno D'Avanzo; Peter H Backx; Saul Goldman; CG Gray
Non-Michaelis-Menten kinetics model for conductance of low-conductance potassium ion channels.
Physical review. E, Statistical, nonlinear, and soft matter physics 2005;71(2 Pt 1):021912.
2005: Suk Ying Tsang; Robert G Tsushima; Gordon F Tomaselli; Ronald A Li; Peter H Backx
A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor.
Molecular pharmacology 2005;67(2):424-34.
2005: Romeo Ricci; Urs Eriksson; Gavin Y Oudit; Robert Eferl; Alexander Akhmedov; Izabela Sumara; Grzegorz Sumara; Zamaneh Kassiri; Jean-Pierre David; Latifa Bakiri; Bernd Sasse; Maria-Helena Idarraga; Martina Rath; David Kurz; Hans-Christian Theussl; Stephan Keller; Peter H Backx; Josef M Penninger; Erwin F Wagner
Distinct functions of junD in cardiac hypertrophy and heart failure.
Genes & development 2005;19(2):208-13.
2004: Patrick E MacDonald; Jamie W Joseph; Daphne Yau; Jingyu Diao; Zeenat Asghar; F Dai; Gavin Y Oudit; Mikin M Patel; Peter H Backx; Michael B Wheeler
Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase.
Endocrinology 2004;145(9):4078-83.
2004: Roberto Diaz; Carsten Zobel; Hee Cheol Cho; Michelle Batthish; Aleksander Hinek; Peter H Backx; Gregory J Wilson
Selective inhibition of inward rectifier K+ channels (Kir2.1 or Kir2.2) abolishes protection by ischemic preconditioning in rabbit ventricular cardiomyocytes.
Circulation research 2004;95(3):325-32.
2004: Gavin Y Oudit; Hui Sun; Benoit-Gilles Kerfant; Michael A Crackower; Josef M Penninger; Peter H Backx
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease.
Journal of molecular and cellular cardiology 2004;37(2):449-71.
2004: Michio Asahi; Kinya Otsu; Hiroyuki Nakayama; Shungo Hikoso; Toshihiro Takeda; Anthony O Gramolini; Maria G Trivieri; Gavin Y Oudit; Takashi Morita; Yoichiro Kusakari; Shuta Hirano; Kenichi Hongo; Shinichi Hirotani; Osamu Yamaguchi; Alan Peterson; Peter H Backx; Satoshi Kurihara; Masatsugu Hori; David H MacLennan
Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9199-204.
2004: Hui Sun; Gavin Y Oudit; Rafael J Ramirez; Danny Costantini; Peter H Backx
The phosphoinositide 3-kinase inhibitor LY294002 enhances cardiac myocyte contractility via a direct inhibition of Ik,slow currents.
Cardiovascular research 2004;62(3):509-20.
2004: Gavin Y Oudit; Maria G Trivieri; Neelam Khaper; Taneya Husain; Gregory J Wilson; Peter Liu; Michael J Sole; Peter H Backx
Taurine supplementation reduces oxidative stress and improves cardiovascular function in an iron-overload murine model.
Circulation 2004;109(15):1877-85.
2003: Gavin Y Oudit; Michael A Crackower; Urs Eriksson; Renu Sarao; Ivona Kozieradzki; Takehiko Sasaki; Junko Irie-Sasaki; Dominica Gidrewicz; Vitalyi O Rybin; Teiji Wada; Susan F Steinberg; Peter H Backx; Josef M Penninger
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.
Circulation 2003;108(17):2147-52.
2003: Gavin Y Oudit; Hui Sun; Maria G Trivieri; Sheryl E Koch; Fayez Dawood; Cameron Ackerley; Mehrdad Yazdanpanah; Gregory J Wilson; Arnold Schwartz; Peter P Liu; Peter H Backx
L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy.
Nature medicine 2003;9(9):1187-94.
2003: Carsten Zobel; Hee Cheol Cho; The-Tin Nguyen; Roman Pekhletski; Roberto Diaz; Gregory J Wilson; Peter H Backx
Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2.
The Journal of physiology 2003;550(Pt 2):365-72.
2003: Gavin Y Oudit; Michael A Crackower; Peter H Backx; Josef M Penninger
The role of ACE2 in cardiovascular physiology.
Trends in cardiovascular medicine 2003;13(3):93-101.
2003: Roberto Diaz; Stephen C Armstrong; Michelle Batthish; Peter H Backx; Charles E Ganote; Gregory J Wilson
Enhanced cell volume regulation: a key protective mechanism of ischemic preconditioning in rabbit ventricular myocytes.
Journal of molecular and cellular cardiology 2003;35(1):45-58.
2003: Gavin Y Oudit; Maria G Trivieri; Peter H Backx
Sulfhydryl modulation of K+ currents: a possible cross-link between oxidative stress and altered cardiovascular function.
Journal of molecular and cellular cardiology 2003;35(1):1-4.
2003: Rajan Sah; Rafael J Ramirez; Gavin Y Oudit; Dominica Gidrewicz; Maria G Trivieri; Carsten Zobel; Peter H Backx
Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)).
The Journal of physiology 2003;546(Pt 1):5-18.
2002: Carsten Zobel; Zamaneh Kassiri; The-Tin T Nguyen; Yang Meng; Peter H Backx
Prevention of hypertrophy by overexpression of Kv4.2 in cultured neonatal cardiomyocytes.
Circulation 2002;106(18):2385-91.
2002: Michael A Crackower; Gavin Y Oudit; Ivona Kozieradzki; Renu Sarao; Hui Sun; Takehiko Sasaki; Emilio Hirsch; Akira Suzuki; Tetsuo Shioi; Junko Irie-Sasaki; Rajan Sah; Hai-Ying M Cheng; Vitalyi O Rybin; Giuseppe Lembo; Luigi Fratta; Antonio J Oliveira-dos-Santos; Jeffery L Benovic; C Ronald Kahn; Seigo Izumo; Susan F Steinberg; Matthias P Wymann; Peter H Backx; Josef M Penninger
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.
Cell 2002;110(6):737-49.
2002: Roger Kaprielian; Rajan Sah; Tin Nguyen; Alan D Wickenden; Peter H Backx
Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, I(to) K(+) currents, and [Ca(2+)](i) transients.
American journal of physiology. Heart and circulatory physiology 2002;283(3):H1157-68.
2002: Michelle Batthish; Roberto Diaz; He-Ping Zeng; Peter H Backx; Gregory J Wilson
Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition.
Cardiovascular research 2002;55(3):660-71.
2002: Michael A Crackower; Renu Sarao; Gavin Y Oudit; Chana Yagil; Ivona Kozieradzki; Sam E Scanga; Antonio J Oliveira-dos-Santos; Joan da Costa; Liyong Zhang; York Pei; James Scholey; Carlos M Ferrario; Armen S Manoukian; Mark C Chappell; Peter H Backx; Yoram Yagil; Josef M Penninger
Angiotensin-converting enzyme 2 is an essential regulator of heart function.
Nature 2002;417(6891):822-8.
2002: Zamaneh Kassiri; Roger Hajjar; Peter H Backx
Molecular components of transient outward potassium current in cultured neonatal rat ventricular myocytes.
Journal of molecular medicine (Berlin, Germany) 2002;80(6):351-8.
2002: Rajan Sah; Gavin Y Oudit; The-Tin T Nguyen; Hae W Lim; Alan D Wickenden; Gregory J Wilson; Jeffery D Molkentin; Peter H Backx
Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice.
Circulation 2002;105(15):1850-6.
2002: Zamaneh Kassiri; Carsten Zobel; The-Tin T Nguyen; Jeffery D Molkentin; Peter H Backx
Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes.
Circulation research 2002;90(5):578-85.
2002: Rajan Sah; Rafael J Ramirez; Peter H Backx
Modulation of Ca(2+) release in cardiac myocytes by changes in repolarization rate: role of phase-1 action potential repolarization in excitation-contraction coupling.
Circulation research 2002;90(2):165-73.
2001: Roberto Diaz; Michelle Batthish; Peter H Backx; Gregory J Wilson
Chloride channel inhibition does block the protection of ischemic preconditioning in myocardium.
Journal of molecular and cellular cardiology 2001;33(10):1887-9; author reply 1891-2.
2001: Patrick E MacDonald; X F Ha; Jing Wang; Simon R Smukler; AM Sun; Herbert Y Gaisano; Anne Marie F Salapatek; Peter H Backx; Michael B Wheeler
Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretion.
Molecular endocrinology (Baltimore, Md.) 2001;15(8):1423-35.
2001: Rajan Sah; Rafael J Ramirez; Roger Kaprielian; Peter H Backx
Alterations in action potential profile enhance excitation-contraction coupling in rat cardiac myocytes.
The Journal of physiology 2001;533(Pt 1):201-14.
2001: Gavin Y Oudit; Zamaneh Kassiri; Rajan Sah; Rafael J Ramirez; Carsten Zobel; Peter H Backx
The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium.
Journal of molecular and cellular cardiology 2001;33(5):851-72.
2000: Elena Zvaritch; Peter H Backx; F Jirik; Y Kimura; Stella de Leon; Albrecht G Schmidt; Brian D Hoit; J William Lester; Evangelia G Kranias; David H MacLennan
The transgenic expression of highly inhibitory monomeric forms of phospholamban in mouse heart impairs cardiac contractility.
The Journal of biological chemistry 2000;275(20):14985-91.
2000: Hee Cheol Cho; Robert G Tsushima; T T Nguyen; H R Guy; Peter H Backx
Two critical cysteine residues implicated in disulfide bond formation and proper folding of Kir2.1.
Biochemistry 2000;39(16):4649-57.
2000: Wally J Bartfay; D Hou; Denis C Lehotay; Xiaoping Luo; Emma Bartfay; Peter H Backx; Peter P Liu
Cytotoxic aldehyde generation in heart following acute iron-loading.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2000;14(1):14-20.
2000: Alan D Wickenden; Roger Kaprielian; X M You; Peter H Backx
The thyroid hormone analog DITPA restores I(to) in rats after myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2000;278(4):H1105-16.
2000: Zamaneh Kassiri; R Myers; Roger Kaprielian; H S Banijamali; Peter H Backx
Rate-dependent changes of twitch force duration in rat cardiac trabeculae: a property of the contractile system.
The Journal of physiology 2000;524 Pt 1():221-31.
1999: Alan D Wickenden; P Lee; Rajan Sah; Q Huang; Glenn I Fishman; Peter H Backx
Targeted expression of a dominant-negative K(v)4.2 K(+) channel subunit in the mouse heart.
Circulation research 1999;85(11):1067-76.
1999: Wally J Bartfay; Fayez Dawood; Wen-Hu Wen; Denis C Lehotay; D Hou; Emma Bartfay; Xiaoping Luo; Peter H Backx; Peter P Liu
Cardiac function and cytotoxic aldehyde production in a murine model of chronic iron-overload.
Cardiovascular research 1999;43(4):892-900.
1999: Ronald A Li; Robert G Tsushima; K Himmeldirk; D S Dime; Peter H Backx
Local anesthetic anchoring to cardiac sodium channels. Implications into tissue-selective drug targeting.
Circulation research 1999;85(1):88-98.
1999: Robert G Tsushima; Alan D Wickenden; R A Bouchard; Gavin Y Oudit; Peter P Liu; Peter H Backx
Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload.
Circulation research 1999;84(11):1302-9.
1999: A Borges; Robert G Tsushima; Peter H Backx
Antibodies against Tityus discrepans venom do not abolish the effect of Tityus serrulatus venom on the rat sodium and potassium channels.
Toxicon : official journal of the International Society on Toxinology 1999;37(6):867-81.
1999: Roger Kaprielian; Alan D Wickenden; Zamaneh Kassiri; Thomas G Parker; Peter P Liu; Peter H Backx
Relationship between K+ channel down-regulation and [Ca2+]i in rat ventricular myocytes following myocardial infarction.
The Journal of physiology 1999;517 ( Pt 1)():229-45.
1999: Alan D Wickenden; Timothy J Jegla; Roger Kaprielian; Peter H Backx
Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle.
The American journal of physiology 1999;276(5 Pt 2):H1599-607.
1999: Roberto Diaz; VA Losito; G D Mao; M K Ford; Peter H Backx; Gregory J Wilson
Chloride channel inhibition blocks the protection of ischemic preconditioning and hypo-osmotic stress in rabbit ventricular myocardium.
Circulation research 1999;84(7):763-75.
1999: Robert G Tsushima; A Borges; Peter H Backx
Inactivated state dependence of sodium channel modulation by beta-scorpion toxin.
Pflügers Archiv : European journal of physiology 1999;437(5):661-8.
1999: Alan D Wickenden; Robert G Tsushima; VA Losito; Roger Kaprielian; Peter H Backx
Effect of Cd2+ on Kv4.2 and Kv1.4 expressed in Xenopus oocytes and on the transient outward currents in rat and rabbit ventricular myocytes.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 1999;9(1):11-28.
1998: VA Losito; Robert G Tsushima; Roberto Diaz; Gregory J Wilson; Peter H Backx
Preferential regulation of rabbit cardiac L-type Ca2+ current by glycolytic derived ATP via a direct allosteric pathway.
The Journal of physiology 1998;511 ( Pt 1)():67-78.
1998: R L Sah; Robert G Tsushima; Peter H Backx
Effects of local anesthetics on Na+ channels containing the equine hyperkalemic periodic paralysis mutation.
The American journal of physiology 1998;275(2 Pt 1):C389-400.
1998: Alan D Wickenden; Roger Kaprielian; Zamaneh Kassiri; james/jim Tsoporis; Robert G Tsushima; Glenn I Fishman; Peter H Backx
The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure.
Cardiovascular research 1998;37(2):312-23.
1997: Alan D Wickenden; Roger Kaprielian; Thomas G Parker; Owen T Jones; Peter H Backx
Effects of development and thyroid hormone on K+ currents and K+ channel gene expression in rat ventricle.
The Journal of physiology 1997;504 ( Pt 2)():271-86.
1997: Ronald A Li; Robert G Tsushima; R G Kallen; Peter H Backx
Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis.
Biophysical journal 1997;73(4):1874-84.
1997: Robert G Tsushima; Ronald A Li; Peter H Backx
P-loop flexibility in Na+ channel pores revealed by single- and double-cysteine replacements.
The Journal of general physiology 1997;110(1):59-72.
1997: Robert G Tsushima; Ronald A Li; Peter H Backx
Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the pore.
The Journal of general physiology 1997;109(4):463-75.
1996: W J Hanna; Robert G Tsushima; R Sah; L Jill McCutcheon; Eduardo Marban; Peter H Backx
The equine periodic paralysis Na+ channel mutation alters molecular transitions between the open and inactivated states.
The Journal of physiology 1996;497 ( Pt 2)():349-64.