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Satwik Kamtekar

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Publications

TOP 3
Christopher J Ritacco; Satwik Kamtekar; Jimin Wang; Thomas A Steitz
Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertase.
Marvin J Meyers; Matthew J Pelc; Jeanne Rumsey; Barbara A Schweitzer; Sarah E Smith; David Beidler; Scott J Bowen; Susan Foltin; Satwik Kamtekar; Scott A Long; Joseph McDonald; Mark C Walker; Jane L Wang; Mark V Wilcox; Young-Sun Yang; Atli Thorarensen
Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain.
Jens Hausmann; Satwik Kamtekar; Evangelos Christodoulou; Jacqueline E Day; Tao Wu; Zachary Fulkerson; Harald M H G Albers; Laurens van Meeteren; Anna J S Houben; Leonie van Zeijl; Silvia Jansen; Maria Andries; Troii Hall; Lyle E Pegg; Timothy E Benson; Mobien Kasiem; Karl Harlos; Craig W Vander Kooi; Susan S Smyth; Huib Ovaa; Mathieu Bollen; Andrew James Morris; Wouter H Moolenaar; Anastassis Perraks
Structural basis of substrate discrimination and integrin binding by autotaxin.

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All Publications

2013: Christopher J Ritacco; Satwik Kamtekar; Jimin Wang; Thomas A Steitz
Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertase.
Nucleic acids research 2013;41(4):2673-82.
2011: Marvin J Meyers; Matthew J Pelc; Jeanne Rumsey; Barbara A Schweitzer; Sarah E Smith; David Beidler; Scott J Bowen; Susan Foltin; Satwik Kamtekar; Scott A Long; Joseph McDonald; Mark C Walker; Jane L Wang; Mark V Wilcox; Young-Sun Yang; Atli Thorarensen
Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain.
Bioorganic & medicinal chemistry letters 2011;21(21):6545-53.
2011: Jens Hausmann; Satwik Kamtekar; Evangelos Christodoulou; Jacqueline E Day; Tao Wu; Zachary Fulkerson; Harald M H G Albers; Laurens van Meeteren; Anna J S Houben; Leonie van Zeijl; Silvia Jansen; Maria Andries; Troii Hall; Lyle E Pegg; Timothy E Benson; Mobien Kasiem; Karl Harlos; Craig W Vander Kooi; Susan S Smyth; Huib Ovaa; Mathieu Bollen; Andrew James Morris; Wouter H Moolenaar; Anastassis Perraks
Structural basis of substrate discrimination and integrin binding by autotaxin.
Nature structural & molecular biology 2011;18(2):198-204.
2010: Jacqueline E Day; Troii Hall; Lyle E Pegg; Timothy E Benson; Jens Hausmann; Satwik Kamtekar
Crystallization and preliminary X-ray diffraction analysis of rat autotaxin.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 9):1127-9.
2010: Zhigang Wang; William Watt; Nathan A Brooks; Melissa S Harris; Jan Urban; Douglas Boatman; Michael McMillan; Michael Kahn; Robert L Heinrikson; Barry C Finzel; Arthur J Wittwer; James Blinn; Satwik Kamtekar; Alfredo G Tomasselli
Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochimica et biophysica acta 2010;1804(9):1817-31.
2010: Mauro Mileni; Satwik Kamtekar; David C Wood; Timothy E Benson; Benjamin F Cravatt; Raymond C Stevens
Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation.
Journal of molecular biology 2010;400(4):743-54.
2010: Marvin J Meyers; Matthew Pelc; Satwik Kamtekar; Jacqueline Day; Gennadiy I Poda; Molly K Hall; Marshall L Michener; Beverly A Reitz; Karl J Mathis; Betsy S Pierce; Mihir D Parikh; Deborah A Mischke; Scott A Long; John J Parlow; David R Anderson; Atli Thorarensen
Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.
Bioorganic & medicinal chemistry letters 2010;20(5):1543-7.
2009: Fang Fang Yin; Scott Bailey; C Axel Innis; Mihai Ciubotaru; Satwik Kamtekar; Thomas A Steitz; David G Schatz
Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.
Nature structural & molecular biology 2009;16(5):499-508.
2009: Kay Ahn; Douglas S Johnson; Mauro Mileni; David Beidler; Jonathan Z Long; Michele K McKinney; Eranthie Weerapana; Nalini Sadagopan; Marya Liimatta; Sarah E Smith; Scott Lazerwith; Cory Stiff; Satwik Kamtekar; Keshab Bhattacharya; Yanhua Zhang; Stephen Swaney; Keri Van Becelaere; Raymond C Stevens; Benjamin F Cravatt
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Chemistry & biology 2009;16(4):411-20.
2008: Mauro Mileni; Douglas S Johnson; Zhigang Wang; Daniel S Everdeen; Marya Liimatta; Brandon Pabst; Keshab Bhattacharya; Richard A Nugent; Satwik Kamtekar; Benjamin F Cravatt; Kay Ahn; Raymond C Stevens
Structure-guided inhibitor design for human FAAH by interspecies active site conversion.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12820-4.
2007: Andrea J Berman; Satwik Kamtekar; Jessica L Goodman; José M Lázaro; Miguel de Vega; Luis Blanco; Margarita Salas; Thomas A Steitz
Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases.
The EMBO journal 2007;26(14):3494-505.
2007: Satwik Kamtekar; Michael J Hohn; Hee-Sung Park; Michael Schnitzbauer; Anselm Sauerwald; Dieter Söll; Thomas A Steitz
Toward understanding phosphoseryl-tRNACys formation: the crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2620-5.
2006: Satwik Kamtekar; Roger S Ho; Melanie Cocco; Weikai Li; Sandra V C T Wenwieser; Martin R Boocock; Nigel D F Grindley; Thomas A Steitz
Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10642-7.
2006: Satwik Kamtekar; Andrea J Berman; Jimin Wang; José M Lázaro; Miguel de Vega; Luis Blanco; Margarita Salas; Thomas A Steitz
The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition.
The EMBO journal 2006;25(6):1335-43.
2005: alexandre ambrogelly; Satwik Kamtekar; Constantinos Stathopoulos; Dexter Kennedy; Dieter Söll
Asymmetric behavior of archaeal prolyl-tRNA synthetase.
FEBS letters 2005;579(27):6017-22.
2005: Weikai Li; Satwik Kamtekar; Yong Xiong; Gary J Sarkis; Nigel D F Grindley; Thomas A Steitz
Structure of a synaptic gammadelta resolvase tetramer covalently linked to two cleaved DNAs.
Science (New York, N.Y.) 2005;309(5738):1210-5.
2005: Irene Rodríguez; José M Lázaro; Luis Blanco; Satwik Kamtekar; Andrea J Berman; Jimin Wang; Thomas A Steitz; Margarita Salas; Miguel de Vega
A specific subdomain in phi29 DNA polymerase confers both processivity and strand-displacement capacity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(18):6407-12.
2005: Jimin Wang; Satwik Kamtekar; Andrea J Berman; Thomas A Steitz
Correction of X-ray intensities from single crystals containing lattice-translocation defects.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 1):67-74.
2004: Satwik Kamtekar; Andrea J Berman; Jimin Wang; José M Lázaro; Miguel de Vega; Luis Blanco; Margarita Salas; Thomas A Steitz
Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29.
Molecular cell 2004;16(4):609-18.
2004: alexandre ambrogelly; Satwik Kamtekar; Anselm Sauerwald; Benfang Ruan; Debra Tumbula Hansen; D Kennedy; Ivan Ahel; Dieter Söll
Cys-tRNACys formation and cysteine biosynthesis in methanogenic archaea: two faces of the same problem?
Cellular and molecular life sciences : CMLS 2004;61(19-20):2437-45.
2003: Satwik Kamtekar; W Dexter Kennedy; Jimin Wang; Constantinos Stathopoulos; Dieter Söll; Thomas A Steitz
The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1673-8.
2001: Jimin Wang; J J Song; Ihn Sik Seong; MC Franklin; Satwik Kamtekar; Soo Hyun Eom; Chin Ha Chung
Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU.
Structure (London, England : 1993) 2001;9(11):1107-16.
2001: Jimin Wang; J J Song; MC Franklin; Satwik Kamtekar; Young Jun Im; S H Rho; Ihn Sik Seong; C S Lee; Chin Ha Chung; Soo Hyun Eom
Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanism.
Structure (London, England : 1993) 2001;9(2):177-84.