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Takanori Kanai

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Kazuaki Yoneno; Tadakazu Hisamatsu; Riko Ichikawa; Nobuhiko Kamada; Takanori Kanai; Mina T Kitazume; Kazutaka Koganei; Katsuyoshi Matsuoka; Maiko Mori; Yuka Namikawa; Toshiro Sato; Katsuyoshi Shimamura; Akira Sugita; Michihide Uo; Toshifumi Hibi
TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease.
Yuji Nakamura; Keita Saeki; Hidetsugu Saito; Takahiro Suzuki; Miho Takabe; Toshiaki Teratani; Yoshiyuki Yamagishi; Hirotoshi Ebinuma; Hajime Higuchi; Tadakazu Hisamatsu; Shigenari Hozawa; Junichiro Irie; Hiroshi Itoh; Takanori Kanai; Yohei Mikami; Naoteru Miyata; Jun Miyoshi; Nobuhiro Nakamoto; Toshifumi Hibi
CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion.
Tadakazu Hisamatsu; Takanori Kanai; Katsuyoshi Matsuoka; Yohei Mikami; Kazuaki Yoneno; Toshifumi Hibi
Immune aspects of the pathogenesis of inflammatory bowel disease.

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All Publications

2013: Kazuaki Yoneno; Tadakazu Hisamatsu; Riko Ichikawa; Nobuhiko Kamada; Takanori Kanai; Mina T Kitazume; Kazutaka Koganei; Katsuyoshi Matsuoka; Maiko Mori; Yuka Namikawa; Toshiro Sato; Katsuyoshi Shimamura; Akira Sugita; Michihide Uo; Toshifumi Hibi
TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease.
Immunology 2013;139(1):19-29.
2013: Yuji Nakamura; Keita Saeki; Hidetsugu Saito; Takahiro Suzuki; Miho Takabe; Toshiaki Teratani; Yoshiyuki Yamagishi; Hirotoshi Ebinuma; Hajime Higuchi; Tadakazu Hisamatsu; Shigenari Hozawa; Junichiro Irie; Hiroshi Itoh; Takanori Kanai; Yohei Mikami; Naoteru Miyata; Jun Miyoshi; Nobuhiro Nakamoto; Toshifumi Hibi
CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion.
American journal of physiology. Gastrointestinal and liver physiology 2013;304(8):G700-7.
2013: Tadakazu Hisamatsu; Takanori Kanai; Katsuyoshi Matsuoka; Yohei Mikami; Kazuaki Yoneno; Toshifumi Hibi
Immune aspects of the pathogenesis of inflammatory bowel disease.
Pharmacology & therapeutics 2013;137(3):283-97.
2013: Tomohisa Sujino; Hirotoshi Ebinuma; Yuuichirou Hayashi; Naoki Hosoe; Hiroyuki Imaeda; Takanori Kanai; Makio Mukai; Haruhiko Ogata; Susumu Okamoto; Toshifumi Hibi
Epstein-barr virus-associated gastritis: a case report.
Digestive diseases and sciences 2013;58(3):883-6.
2013: Tango Handa; Atsushi Hayashi; Tadakazu Hisamatsu; Takanori Kanai; Atsuhiro Matsumoto; Yohei Mikami; Shinta Mizuno; Toshiro Sato; Tomohisa Sujino; Toshifumi Hibi
Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice.
Immunology letters 2013;150(1-2):123-9.
2013: Atsuhiro Matsumoto; Yohei Mikami; Nobuhiro Nakamoto; Hidetsugu Saito; Toshiro Sato; Hideo Yagita; Po-Sung Chu; Hirotoshi Ebinuma; Takanori Kanai; Toshifumi Hibi
IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis.
PloS one 2013;8(4):e62853.
2013: Hideko Akagi; Shinsuke Funakoshi; Yasuo Hamamoto; Masayuki Adachi; Hajime Higuchi; Toru Igarashi; Motoko Izumiya; Ayano Kabashima; Takanori Kanai; Yutaka Kawakami; Hiroyuki Mizuguchi; Shoko Nakamura; Gen Sakai; Hidetoshi Sumimoto; Hiromasa Takaishi; Toshifumi Hibi
Suppression of myeloid cell leukemia-1 (Mcl-1) enhances chemotherapy-associated apoptosis in gastric cancer cells.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2013;16(1):100-10.
2012: Yuji Koike; Yohei Mikami; Nobuhiro Nakamoto; Yuji Nakamura; Masaru Nakano; Keita Saeki; Yoshiyuki Yamagishi; Hirotoshi Ebinuma; Takanori Kanai; Toshifumi Hibi
MyD88-dependent interleukin-10 production from regulatory CD11b⁺Gr-1(high) cells suppresses development of acute cerulein pancreatitis in mice.
Immunology letters 2012;148(2):172-7.
2012: Kayoko Kimura; Katsuyoshi Matsuoka; Yohei Mikami; Shinta Mizuno; Toshiro Sato; Tomohisa Sujino; Tango Handa; Atsushi Hayashi; Tadakazu Hisamatsu; Takanori Kanai; Toshifumi Hibi
Dysregulated balance of retinoid-related orphan receptor γt-dependent innate lymphoid cells is involved in the pathogenesis of chronic DSS-induced colitis.
Biochemical and biophysical research communications 2012;427(4):694-700.
2012: Yuichi Ono; Tomohisa Sujino; Hiromasa Takaishi; Mamoru Watanabe; Atsushi Hayashi; Tadakazu Hisamatsu; Takanori Kanai; Yasumasa Kanai; Atsuhiro Matsumoto; Katsuyoshi Matsuoka; Yohei Mikami; Yasuhiro Nemoto; Haruhiko Ogata; Toshifumi Hibi
T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice.
Gastroenterology 2012;143(5):1288-97.
2012: Naoki Hosoe; Riko Ichikawa; Hiroyuki Imaeda; Nagamu Inoue; Takanori Kanai; Manabu Nakashita; Rieko Bessho; Toshifumi Hibi; Tomohisa Sujino; Haruhiko Ogata
Comparison of patient acceptance of sodium phosphate versus polyethylene glycol plus sodium picosulfate for colon cleansing in Japanese.
Journal of gastroenterology and hepatology 2012;27(10):1617-22.
2012: Kengo Tomita; Junji Yamamoto; Hirokazu Yokoyama; Yohko Yoshida; Hirotoshi Ebinuma; Kazuo Hatsuse; Ryota Hokari; Rie Irie; Takanori Kanai; Chie Kurihara; Norikazu Mataki; Tohru Minamino; Soichiro Miura; Kiyoshi Nishiyama; Yoshikiyo Okada; Tetsuya Oshikawa; Hidetsugu Saito; Katsuyoshi Shimamura; Ippei Shimizu; Kazuo Sugiyama; Takahiro Suzuki; Toshiaki Teratani; Toshifumi Hibi
p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.
Journal of hepatology 2012;57(4):837-43.
2012: Tomomitsu Doi; Atsushi Hayashi; Li Jun; Takanori Kanai; Yohei Mikami; Yuichi Ono; Tomohisa Sujino; Toshifumi Hibi
IgA plasma cells express the negative regulatory co-stimulatory molecule programmed cell death 1 ligand and have a potential tolerogenic role in the intestine.
Biochemical and biophysical research communications 2012;425(4):918-23.
2012: Gen Sakai; Hiromasa Takaishi; Tomoharu Yajima; Masayuki Adachi; Hideko Akagi; Shinsuke Funakoshi; Yasuo Hamamoto; Hajime Higuchi; Motoko Izumiya; Takanori Kanai; Takehiko Mori; Makio Mukai; Shoko Nakamura; Shinichiro Okamoto; Toshifumi Hibi
Colon neoplastic cells do not originate from bone marrow-derived cells after sex-mismatched bone marrow transplantation.
Anticancer research 2012;32(9):4097-103.
2012: Takahiro Mizukami; Toshiro Sato; Tomomitsu Doi; Tango Handa; Atsushi Hayashi; Tadakazu Hisamatsu; Li Jun; Takanori Kanai; Atsuhiro Matsumoto; Katsuyoshi Matsuoka; Yohei Mikami; Toshifumi Hibi
CCR9+ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis.
Immunology letters 2012;147(1-2):75-9.
2012: Hiromasa Takaishi; Masao Takemura; Tomoharu Yajima; Shigeo Yoshizawa; Yasushi Iwao; Takanori Kanai; Atsushi Nakazawa; Akira Nikai; Shoichi Ozaki; Fumihiko Sugata; Shinsuke Funakoshi; Yasuo Hamamoto; Toshifumi Hibi
Anti-high mobility group box 1 and box 2 non-histone chromosomal proteins (HMGB1/HMGB2) antibodies and anti-Saccharomyces cerevisiae antibodies (ASCA): accuracy in differentially diagnosing UC and CD and correlation with inflammatory bowel disease phenotype.
Journal of gastroenterology 2012;47(9):969-77.
2012: Shinta Mizuno; Nobuhiro Nakamoto; Yuichi Ono; Tomohisa Sujino; Hiromasa Takaishi; Tadakazu Hisamatsu; Takanori Kanai; Atsuhiro Matsumoto; Katsuyoshi Matsuoka; Yohei Mikami; Tango Handa; Atsushi Hayashi; Toshifumi Hibi
CCR9+ plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice.
Immunology letters 2012;146(1-2):64-9.
2012: Yosuke Ida; Hiroyuki Imaeda; Takanori Kanai; Makoto Naganuma; Rieko Bessho; Toshifumi Hibi; Naoki Hosoe; Riko Ichikawa; Haruhiko Ogata
Effects of the oral administration of mosapride citrate on capsule endoscopy completion rate.
Gut and liver 2012;6(3):339-43.
2012: Hiroyuki Imaeda; Yasushi Iwao; Takanori Kanai; Kazuhiro Kashiwagi; Hiromasa Nakamizo; Toshifumi Hibi; Naoki Hosoe; Yosuke Ida; Haruhiko Ogata
Novel technique of endoscopic submucosal dissection by using external forceps for early rectal cancer (with videos).
Gastrointestinal endoscopy 2012;75(6):1253-7.
2012: Riko Ichikawa; Hiroshi Itoh; Nobuhiko Kamada; Takanori Kanai; Mina T Kitazume; Katsuyoshi Matsuoka; Tetsuro Takayama; Mitsuhiro Watanabe; Kazuaki Yoneno; Hajime Higuchi; Tadakazu Hisamatsu; Toshifumi Hibi
Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway.
Immunology 2012;136(2):153-62.
2012: Ken Hatogai; Toshifumi Hibi; Naoki Hosoe; Yosuke Ida; Hiroyuki Imaeda; Yuka Ishibashi; Takanori Kanai; Kayoko Kimura; Sawako Okada; Jean-François Rey; Nobuhiro Tsukada; Shingo Usui; Kazuaki Yoneno; Haruhiko Ogata
Role of enhanced visibility in evaluating polyposis syndromes using a newly developed contrast image capsule endoscope.
Gut and liver 2012;6(2):218-22.
2012: Keita Saeki; Tomohisa Sujino; Hiromasa Takaishi; Kazuyoshi Takeda; Yoshiyuki Yamagishi; Akihiko Yoshimura; Shigenari Hozawa; Takanori Kanai; Naoteru Miyata; Yuji Nakamura; Masaru Nakano; Yuuichi Ono; Hirotoshi Ebinuma; Toshifumi Hibi
CCL2-induced migration and SOCS3-mediated activation of macrophages are involved in cerulein-induced pancreatitis in mice.
Gastroenterology 2012;142(4):1010-1020.e9.
2012: Osamu Yamaji; Hisashi Arase; Atsuhiko Hasegawa; Takanori Kanai; Takashi Nagaishi; Tetsuya Nakamura; Ryuichi Okamoto; Michio Onizawa; Masahiro Suzuki; Teruji Totsuka; Kiichiro Tsuchiya; Naoto Tsuge; Mamoru Watanabe
The development of colitogenic CD4(+) T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(6):2524-36.
2012: Takanori Kanai; Katsuyoshi Matsuoka; Haruhiko Ogata; Tadakazu Hisamatsu; Yasushi Iwao; Toshifumi Hibi
[Mechanism and therapeutic strategy of second failure of infliximab treatment for Crohn's disease].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2012;109(3):364-9.
2012: Takanori Kanai
[Mechanism of pathogenesis of inflammatory bowel diseases].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 1():59-65.
2012: Nobuhiro Nakamoto; Keisuke Ojiro; Yuichi Ono; Hidetsugu Saito; Takanori Kanai; Martin Lipp; Paul E Love; Yohei Mikami; Po-Sung Chu; Hirotoshi Ebinuma; Toshifumi Hibi
CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis.
Gastroenterology 2012;142(2):366-76.
2012: Naoki Hosoe; Riko Ichikawa; Yosuke Ida; Hiroyuki Imaeda; Takanori Kanai; Makoto Naganuma; Rieko Bessho; Toshifumi Hibi; Jean-François Rey; Haruhiko Ogata
Evaluations of capsule endoscopy software in reducing the reading time and the rate of false negatives by inexperienced endoscopists.
Clinics and research in hepatology and gastroenterology 2012;36(1):66-71.
2012: Yuriko Maruyama; Katsuyoshi Matsuoka; Makoto Naganuma; Haruhiko Ogata; Tadakazu Hisamatsu; Nagamu Inoue; Yasushi Iwao; Takanori Kanai; Toshifumi Hibi
A case of intestinal Behçet's disease treated with infliximab monotherapy who successfully maintained clinical remission and complete mucosal healing for six years.
Internal medicine (Tokyo, Japan) 2012;51(16):2125-9.
2012: Tadakazu Hisamatsu; Nagamu Inoue; Yasushi Iwao; Takanori Kanai; Mina T Kitazume; Katsuyoshi Matsuoka; Takahiko Muramatsu; Haruhiko Ogata; Susumu Okamoto; Nobukazu Ono; Ryosei Sakai; Manabu Suzuki; Michihide Uo; Tomoharu Yajima; Minoru Yamakado; Toshihiko Ando; Ayatoshi Andou; Masaki Hashimoto; Toshifumi Hibi
Novel, objective, multivariate biomarkers composed of plasma amino acid profiles for the diagnosis and assessment of inflammatory bowel disease.
PloS one 2012;7(1):e31131.
2011: Yasuhiro Nemoto; Ryuichi Okamoto; Tamako Shinohara; Kiichiro Tsuchiya; Yoshinobu Eishi; Takashi Ito; Takanori Kanai; Martin Lipp; Tetsuya Nakamura; Mamoru Watanabe
Luminal CD4⁺ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation.
Gastroenterology 2011;141(6):2130-2139.e11.
2011: Rieko Bessho; Naoki Hosoe; Nagamu Inoue; Takanori Kanai; Taku Kobayashi; Makio Mukai; Haruhiko Ogata; Tetsuro Takayama; Toshifumi Hibi
Correlation between endocytoscopy and conventional histopathology in microstructural features of ulcerative colitis.
Journal of gastroenterology 2011;46(10):1197-202.
2011: Hirotoshi Ebinuma; Po-sung Chu; Yuka Ishibashi; Takanori Kanai; Masahiro Kikuchi; Mina Komuta; Nobuhiro Nakamoto; Kiyoshi Ohkuma; Keisuke Ojiro; Hidetsugu Saito; Michiie Sakamoto; Tetsurou Takayama; Rumiko Umeda; Shingo Usui; Kanji Wakabayashi; Yoshiyuki Yamagishi; Toshifumi Hibi
Evaluation of liver fibrosis by transient elastography using acoustic radiation force impulse: comparison with Fibroscan(®).
Journal of gastroenterology 2011;46(10):1238-48.
2011: Naoki Hosoe; Yosuke Ida; Hiroyuki Imaeda; Takanori Kanai; Seiki Kobayashi; Rieko Bessho; Toshifumi Hibi; Susumu Okamoto; Riko Saito; Haruhiko Ogata
A case of beef tapeworm (Taenia saginata) infection observed by using video capsule endoscopy and radiography (with videos).
Gastrointestinal endoscopy 2011;74(3):690-1.
2011: Jun Miyoshi; Makio Mukai; Atsushi Nakazawa; Haruhiko Ogata; Susumu Okamoto; Katsuyoshi Shimamura; Tomoharu Yajima; Tadakazu Hisamatsu; Nagamu Inoue; Yasushi Iwao; Takanori Kanai; Katsuyoshi Matsuoka; Toshifumi Hibi
Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn's disease.
Journal of gastroenterology 2011;46(9):1056-63.
2011: Tomohisa Sujino; Hiromasa Takaishi; Akihiko Yoshimura; Tomomitsu Doi; Atsushi Hayashi; Tadakazu Hisamatsu; Takanori Kanai; Dan R Littman; Katsuyoshi Matsuoka; Yohei Mikami; Haruhiko Ogata; Yuichi Ono; Toshifumi Hibi
Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells.
Gastroenterology 2011;141(3):1014-23.
2011: H Naruse; T Hisamatsu; Y Yamauchi; J E Chang; K Matsuoka; M T Kitazume; K Arai; S Ando; Takanori Kanai; N Kamada; Toshifumi Hibi
Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages.
Clinical and experimental immunology 2011;164(1):137-44.
2011: Tamako Shinohara; Yasuhiro Nemoto; Takanori Kanai; Kaori Kameyama; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Teruji Totsuka; Koichi Ikuta; Mamoru Watanabe
Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2623-32.
2011: Tetsuro Takayama; Kanji Wakabayashi; Yoshiyuki Yamagishi; Hirotoshi Ebinuma; Toshifumi Hibi; Takanori Kanai; Keisuke Ojiro; Hidetsugu Saito; Shinichiro Tada
Prediction of effect of pegylated interferon alpha-2b plus ribavirin combination therapy in patients with chronic hepatitis C infection.
PloS one 2011;6(12):e27223.
2011: R Ichikawa; Naoki Hosoe; Hiroyuki Imaeda; K Takabayashi; R Bessho; Y Ida; Makoto Naganuma; Tadakazu Hisamatsu; Nagamu Inoue; Takanori Kanai; Yasushi Iwao; Makio Mukai; Toshifumi Hibi; Haruhiko Ogata
Evaluation of small-intestinal abnormalities in adult patients with Henoch-Schönlein purpura using video capsule.
Endoscopy 2011;43 Suppl 2 UCTN():E162-3.
2010: Keisuke Ojiro; Hirotoshi Ebinuma; Nobuhiro Nakamoto; Kanji Wakabayashi; Yohei Mikami; Yuichi Ono; Chu Po-Sung; Shingo Usui; Rumiko Umeda; Hiromasa Takaishi; Yoshiyuki Yamagishi; Hidetsugu Saito; Takanori Kanai; Toshifumi Hibi
MyD88-dependent pathway accelerates the liver damage of Concanavalin A-induced hepatitis.
Biochemical and biophysical research communications 2010;399(4):744-9.
2010: Yohei Mikami; Takanori Kanai; Tomohisa Sujino; Yuichi Ono; Atsushi Hayashi; Akira Okazawa; Nobuhiko Kamada; Katsuyoshi Matsuoka; Tadakazu Hisamatsu; Susumu Okamoto; Hiromasa Takaishi; Nagamu Inoue; Haruhiko Ogata; Toshifumi Hibi
Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.
European journal of immunology 2010;40(9):2409-22.
2010: Tetsuro Takayama; Nobuhiko Kamada; Hiroshi Chinen; Susumu Okamoto; Mina T Kitazume; Jonathan Chang; Yumi Matuzaki; Sadafumi Suzuki; Akira Sugita; Kazutaka Koganei; Tadakazu Hisamatsu; Takanori Kanai; Toshifumi Hibi
Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.
Gastroenterology 2010;139(3):882-92, 892.e1-3.
2010: Kaori Kameyama; Yasuhiro Nemoto; Takanori Kanai; Tamako Shinohara; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Naoya Sakamoto; Teruji Totsuka; Toshifumi Hibi; Mamoru Watanabe
IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis.
European journal of immunology 2010;40(9):2423-36.
2010: Naoki Hosoe; Taku Kobayashi; Takanori Kanai; Rieko Bessho; Tetsuro Takayama; Nagamu Inoue; Hiroyuki Imaeda; Yasushi Iwao; Seiki Kobayashi; Makio Mukai; Haruhiko Ogata; Toshifumi Hibi
In vivo visualization of trophozoites in patients with amoebic colitis by using a newly developed endocytoscope.
Gastrointestinal endoscopy 2010;72(3):643-6.
2010: Makoto Naganuma; Hitoshi Ichikawa; Nagamu Inoue; Taku Kobayashi; Susumu Okamoto; Tadakazu Hisamatsu; Takanori Kanai; Haruhiko Ogata; Yasushi Iwao; Toshifumi Hibi
Novel endoscopic activity index is useful for choosing treatment in severe active ulcerative colitis patients.
Journal of gastroenterology 2010;45(9):936-43.
2010: Nobuhiko Kamada; Tadakazu Hisamatsu; Haruki Honda; Taku Kobayashi; Hiroshi Chinen; Tetsuro Takayama; Mina T Kitazume; Susumu Okamoto; Kazutaka Koganei; Akira Sugita; Takanori Kanai; Toshifumi Hibi
TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease.
Inflammatory bowel diseases 2010;16(4):568-75.
2010: Yasuhiro Takada; Tadakazu Hisamatsu; Nobuhiko Kamada; Mina T Kitazume; Haruki Honda; Yosuke Oshima; Riko Saito; Tetsuro Takayama; Taku Kobayashi; Hiroshi Chinen; Yohei Mikami; Takanori Kanai; Susumu Okamoto; Toshifumi Hibi
Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(5):2671-6.
2009: Takanori Kanai; Mamoru Watanabe; Toshifumi Hibi
Systemically circulating colitogenic memory CD4+T cells may be an ideal target for the treatment of inflammatory bowel diseases.
The Keio journal of medicine 2009;58(4):203-9.
2009: Yasuhiro Nemoto; Takanori Kanai; Kaori Kameyama; Tamako Shinohara; Naoya Sakamoto; Teruji Totsuka; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Tetsuo Sudo; Satoshi Matsumoto; Mamoru Watanabe
Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5059-68.
2009: Takayuki Tomita; Takanori Kanai; Teruji Totsuka; Yasuhiro Nemoto; Ryuichi Okamoto; Kiichiro Tsuchiya; Naoya Sakamoto; Toshiaki Ohteki; Toshifumi Hibi; Mamoru Watanabe
IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis.
European journal of immunology 2009;39(10):2737-47.
2009: Nobuhiko Kamada; Tadakazu Hisamatsu; Haruki Honda; Taku Kobayashi; Hiroshi Chinen; Mina Tokutake Kitazume; Tetsuro Takayama; Susumu Okamoto; Kazutaka Koganei; Akira Sugita; Takanori Kanai; Toshifumi Hibi
Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1724-31.
2009: Takanori Kanai; Yasuhiro Nemoto; Nobuhiko Kamada; Teruji Totsuka; Tadakazu Hisamatsu; Mamoru Watanabe; Toshifumi Hibi
Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease.
Current opinion in gastroenterology 2009;25(4):306-13.
2009: Takanori Kanai; Yasuhiro Nemoto; Takayuki Tomita; Teruji Totsuka; Mamoru Watanabe; Toshifumi Hibi
Persistent retention of colitogenic CD4+ memory T cells causes inflammatory bowel diseases to become intractable.
Inflammatory bowel diseases 2009;15(6):926-34.
2009: Teruji Totsuka; Takanori Kanai; Yasuhiro Nemoto; Takayuki Tomita; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Naoya Sakamoto; Hisaya Akiba; Ko Okumura; Hideo Yagita; Mamoru Watanabe
RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):6079-87.
2009: Akihiro Araki; Kiichiro Tsuchiya; Eriko Okada; Shinji Suzuki; Shigeru Oshima; Sanae Yoshioka; Atsushi Yoshioka; Takanori Kanai; Mamoru Watanabe
Single-operator double-balloon endoscopy (DBE) is as effective as dual-operator DBE.
Journal of gastroenterology and hepatology 2009;24(5):770-5.
2009: Michio Onizawa; Takashi Nagaishi; Takanori Kanai; Ken-ichi Nagano; Shigeru Oshima; Yasuhiro Nemoto; Atsushi Yoshioka; Teruji Totsuka; Ryuichi Okamoto; Tetsuya Nakamura; Naoya Sakamoto; Kiichiro Tsuchiya; Kazuhiro Aoki; Keiichi Ohya; Hideo Yagita; Mamoru Watanabe
Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(4):G850-9.
2009: Minekazu Murayama; Ryuichi Okamoto; Kiichiro Tsuchiya; Junko Akiyama; Tetsuya Nakamura; Naoya Sakamoto; Takanori Kanai; Mamoru Watanabe
Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells.
Journal of gastroenterology 2009;44(3):173-82.
2009: Ryuichi Okamoto; Kiichiro Tsuchiya; Yasuhiro Nemoto; Junko Akiyama; Tetsuya Nakamura; Takanori Kanai; Mamoru Watanabe
Requirement of Notch activation during regeneration of the intestinal epithelia.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(1):G23-35.
2009: Yuko Sekine-Osajima; Naoya Sakamoto; Mina Nakagawa; Yasuhiro Itsui; Megumi Tasaka; Yuki Nishimura-Sakurai; Cheng-Hsin Chen; Goki Suda; Kako Mishima; Yuko Onuki; Machi Yamamoto; Shinya Maekawa; Nobuyuki Enomoto; Takanori Kanai; Kiichiro Tsuchiya; Mamoru Watanabe
Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication.
Hepatology research : the official journal of the Japan Society of Hepatology 2009;39(1):60-9.
2008: Toshimitsu Fujii; Takayuki Tomita; Takanori Kanai; Yasuhiro Nemoto; Teruji Totsuka; Naoya Sakamoto; Tetsuya Nakamura; Kiichiro Tsuchiya; Ryuichi Okamoto; Mamoru Watanabe
FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow.
European journal of immunology 2008;38(12):3290-303.
2008: Takayuki Tomita; Takanori Kanai; Yasuhiro Nemoto; Toshimitsu Fujii; Kengo Nozaki; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Naoya Sakamoto; Teruji Totsuka; Mamoru Watanabe
Colitogenic CD4+ effector-memory T cells actively recirculate in chronic colitic mice.
Inflammatory bowel diseases 2008;14(12):1630-40.
2008: Yasuhiro Nemoto; Takanori Kanai; Shuji Tohda; Teruji Totsuka; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Naoya Sakamoto; Tetsuya Fukuda; Osamu Miura; Hideo Yagita; Mamoru Watanabe
Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis.
Inflammatory bowel diseases 2008;14(11):1491-503.
2008: Atsushi Yoshioka; Ryuichi Okamoto; Shigeru Oshima; Junko Akiyama; Kiichiro Tsuchiya; Tetsuya Nakamura; Takanori Kanai; Mamoru Watanabe
Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells.
Cytokine 2008;44(1):57-64.
2008: Kimihiro Hino; Kiichiro Tsuchiya; Taro Fukao; Kotaro Kiga; Ryuichi Okamoto; Takanori Kanai; Mamoru Watanabe
Inducible expression of microRNA-194 is regulated by HNF-1alpha during intestinal epithelial cell differentiation.
RNA (New York, N.Y.) 2008;14(7):1433-42.
2008: Teruji Totsuka; Takanori Kanai; Yasuhiro Nemoto; Takayuki Tomita; Kiichiro Tsuchiya; Naoya Sakamoto; Ryuichi Okamoto; Mamoru Watanabe
Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis.
European journal of immunology 2008;38(5):1275-86.
2008: Takayuki Tomita; Takanori Kanai; Toshimitsu Fujii; Yasuhiro Nemoto; Ryuichi Okamoto; Kiichiro Tsuchiya; Teruji Totsuka; Naoya Sakamoto; Mamoru Watanabe
Continuous generation of colitogenic CD4(+) T cells in persistent colitis.
European journal of immunology 2008;38(5):1264-74.
2008: Mikayo Aragaki; Kiichiro Tsuchiya; Ryuichi Okamoto; Sanae Yoshioka; Tetsuya Nakamura; Naoya Sakamoto; Takanori Kanai; Mamoru Watanabe
Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer.
Biochemical and biophysical research communications 2008;368(4):923-9.
2008: Takayuki Tomita; Takanori Kanai; Toshimitsu Fujii; Yasuhiro Nemoto; Ryuichi Okamoto; Kiichiro Tsuchiya; Teruji Totsuka; Naoya Sakamoto; Shizuo Akira; Mamoru Watanabe
MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5291-9.
2008: Yuko Sekine-Osajima; Naoya Sakamoto; Kako Mishima; Mina Nakagawa; Yasuhiro Itsui; Megumi Tasaka; Yuki Nishimura-Sakurai; Cheng-Hsin Chen; Takanori Kanai; Kiichiro Tsuchiya; Takaji Wakita; Nobuyuki Enomoto; Mamoru Watanabe
Development of plaque assays for hepatitis C virus-JFH1 strain and isolation of mutants with enhanced cytopathogenicity and replication capacity.
Virology 2008;371(1):71-85.
2008: Tetsuya Nakamura; Masakazu Nagahori; Takanori Kanai; Mamoru Watanabe
Current pharmacologic therapies and emerging alternatives in the treatment of ulcerative colitis.
Digestion 2008;77 Suppl 1():36-41.
2008: Takayuki Tomita; Takanori Kanai; Yasuhiro Nemoto; Teruji Totsuka; Ryuichi Okamoto; Kiichiro Tsuchiya; Naoya Sakamoto; Mamoru Watanabe
Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):383-90.
2008: Yoshiaki Ito; Takanori Kanai; Teruji Totsuka; Ryuichi Okamoto; Ken Tsuchiya; Yasuhiro Nemoto; A Yoshioka; T Tomita; T Nagaishi; N Sakamoto; T Sakanishi; Ko Okumura; Hideo Yagita; Masahiko Watanabe
Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(1):G199-207.
2007: Shin Makita; Takanori Kanai; Yasuhiro Nemoto; Teruji Totsuka; Ryuichi Okamoto; Kiichiro Tsuchiya; Masafumi Yamamoto; Hiroshi Kiyono; Mamoru Watanabe
Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4937-46.
2007: Teruji Totsuka; Takanori Kanai; Yasuhiro Nemoto; Shin Makita; Ryuichi Okamoto; Kiichiro Tsuchiya; Mamoru Watanabe
IL-7 Is essential for the development and the persistence of chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4737-48.
2007: Takeshi Nagamatsu; Tomoyuki Fujii; Junko Matsumoto; Takanori Kanai; Hironobu Hyodo; Takahiro Yamashita; Shiro Kozuma; Yuji Taketani
Theoretical basis for herbal medicines, Tokishakuyaku-San and Sairei-To, in the treatment of recurrent abortion: enhancing the production of granulocyte-macrophage colony-stimulating factor in decidual stromal cells.
American journal of reproductive immunology (New York, N.Y. : 1989) 2007;57(4):287-93.
2007: Takanori Kanai; Shin Makita; Takahiro Kawamura; Yasuhiro Nemoto; Daisuke Kubota; Kazuyoshi Nagayama; Teruji Totsuka; Mamoru Watanabe
Extracorporeal elimination of TNF-alpha-producing CD14(dull)CD16(+) monocytes in leukocytapheresis therapy for ulcerative colitis.
Inflammatory bowel diseases 2007;13(3):284-90.
2007: Mamoru Watanabe; Daisuke Kubota; Masakazu Nagahori; Takanori Kanai
Treatment of inflammatory immunologic disease 1. Leukocytapheresis for inflammatory immunologic disease (tentative).
Internal medicine (Tokyo, Japan) 2007;46(16):1305-6.
2007: Kiichiro Tsuchiya; Tetsuya Nakamura; Ryuichi Okamoto; Takanori Kanai; Mamoru Watanabe
Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer.
Gastroenterology 2007;132(1):208-20.
2007: Yasuhiro Nemoto; Takanori Kanai; Shin Makita; Ryuichi Okamoto; Teruji Totsuka; Kiyoshi Takeda; Mamoru Watanabe
Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis.
Gastroenterology 2007;132(1):176-89.
2007: Daisuke Kubota; Takanori Kanai; Fumiro Yui; Tomoko Matsumoto; Takahiro Kawamura; Yasuhiro Itsui; Eriko Okada; Seishin Chin; Shinya Ooka; Masakazu Nagahori; Kiichiro Tsuchiya; Akihiro Araki; Naoya Sakamoto; Tatsuya Miyata; Mamoru Watanabe
[Case of severe ulcerative colitis successfully treated with intravenous cyclosporine without high dose corticosteroid].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2007;104(1):42-6.
2006: Norio Hanafusa; Eisei Noiri; Takahiro Yamashita; Yasushi Kondo; Makoto Suzuki; Yasuyuki Watanabe; Takanori Kanai; Emiko Miyashita; Nelson H Tsuno; Tomoyuki Fujii; Shiro Kozuma; Koki Takahashi; Yuji Taketani; Akihide Nakao; Toshiro Fujita
Successful treatment by double filtrate plasmapheresis in a pregnant woman with the rare P blood group and a history of multiple early miscarriages.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 2006;10(6):498-503.
2006: Daisuke Kubota; Chizuru Takishima; Ken-ichi Ishii; Takahiro Kawamura; Tomoko Matsumoto; Yasuhiro Itsui; Eriko Okada; Seishin Chin; Shinya Oooka; Kiichiro Tsuchiya; Akihiro Araki; Naoya Sakamoto; Tatsuya Miyata; Takanori Kanai; Mamoru Watanabe
[A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2006;103(9):1044-9.
2006: Daisuke Kubota; Takanori Kanai; Tomoko Matsumoto; Takahiro Kawamura; Yasuhiro Itsui; Eriko Okada; Seishin Chin; Shinya Ohoka; Kiichiro Tsuchiya; Akihiro Araki; Naoya Sakamoto; Tatsuya Miyata; Mamoru Watanabe
[A case of sacroiliitis complicated by ulcerative colitis that was successfully treated with steroid].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2006;103(8):936-42.
2006: Rei Fujii; Takanori Kanai; Yasuhiro Nemoto; Shin Makita; Shigeru Oshima; Ryuichi Okamoto; Ken Tsuchiya; Teruji Totsuka; Masahiko Watanabe
FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(2):G267-74.
2006: Takanori Kanai; Koji Uraushihara; Teruji Totsuka; Yasuhiro Nemoto; Rei Fujii; Takahiro Kawamura; Shin Makita; Daisuke Sawada; Hideo Yagita; Ko Okumura; Mamoru Watanabe
Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis.
Journal of gastroenterology and hepatology 2006;21(7):1136-42.
2006: Takanori Kanai; Toshifumi Hibi; Mamoru Watanabe
The logics of leukocytapheresis as a natural biological therapy for inflammatory bowel disease.
Expert opinion on biological therapy 2006;6(5):453-66.
2006: Takanori Kanai; K Tanimoto; Yasuhiro Nemoto; Rei Fujii; Shin Makita; Teruji Totsuka; Masahiko Watanabe
Naturally arising CD4+CD25+ regulatory T cells suppress the expansion of colitogenic CD4+CD44highCD62L- effector memory T cells.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(5):G1051-8.
2006: Takanori Kanai; Takahiro Kawamura; Taeko Dohi; Shin Makita; Yasuhiro Nemoto; Teruji Totsuka; Mamoru Watanabe
TH1/TH2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice.
Inflammatory bowel diseases 2006;12(2):89-99.
2005: Hidehiko Matsukawa; Takanori Kanai; Makoto Naganuma; Nobuhiko Kamada; Tadakazu Hisamatsu; Hiromasa Takaishi; Haruhiko Ogata; Makio Mukai; Hiromasa Ishii; Tsuneyo Mimori; Mamoru Watanabe; Toshifumi Hibi
A novel apoptosis-inducing monoclonal antibody (anti-LHK) against a cell surface antigen on colon cancer cells.
Journal of gastroenterology 2005;40(10):945-55.
2005: Takanori Kanai; Mamoru Watanabe
[New concept of cell therapy using regulatory T cells for the treatment of inflammatory bowel disease].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2005;102(9):1132-8.
2005: Tomoko Matsumoto; Ryuichi Okamoto; Tomoharu Yajima; Takehiko Mori; Shinichiro Okamoto; Yasuo Ikeda; Makio Mukai; Motomi Yamazaki; Shigeru Oshima; Kiichiro Tsuchiya; Tetsuya Nakamura; Takanori Kanai; Hideyuki Okano; Johji Inazawa; Toshifumi Hibi; Mamoru Watanabe
Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine.
Gastroenterology 2005;128(7):1851-67.
2005: Teruji Totsuka; Takanori Kanai; Shin Makita; Rei Fujii; Yasuhiro Nemoto; Shigeru Oshima; Ryuichi Okamoto; Akemi Koyanagi; Hisaya Akiba; Ko Okumura; Hideo Yagita; Mamoru Watanabe
Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells.
European journal of immunology 2005;35(6):1773-85.
2005: Shin Namiki; Tetsuya Nakamura; Shigeru Oshima; Motomi Yamazaki; Yuko Sekine; Kiichiro Tsuchiya; Ryuichi Okamoto; Takanori Kanai; Mamoru Watanabe
IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.
FEBS letters 2005;579(13):2781-7.
2005: Toshiyuki Tahara; Nagamu Inoue; Tadakazu Hisamatsu; Kazuhiro Kashiwagi; Hiromasa Takaishi; Takanori Kanai; Mamoru Watanabe; Hiromasa Ishii; Toshifumi Hibi
Clinical significance of microsatellite instability in the inflamed mucosa for the prediction of colonic neoplasms in patients with ulcerative colitis.
Journal of gastroenterology and hepatology 2005;20(5):710-5.
2005: Takanori Kanai; Mamoru Watanabe
Clinical application of human CD4+ CD25+ regulatory T cells for the treatment of inflammatory bowel diseases.
Expert opinion on biological therapy 2005;5(4):451-62.
2005: Takanori Kanai; Mamoru Watanabe
[Immune responses in intestinal mucosa].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 4():459-67.
2005: Eriko Okada; Motomi Yamazaki; Masanobu Tanabe; Tsutomu Takeuchi; Masanobu Nanno; Shigeru Oshima; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Takanori Kanai; Toshifumi Hibi; Mamoru Watanabe
IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(4):G745-54.
2005: Akihiro Araki; Takanori Kanai; Takahiro Ishikura; Shin Makita; Koji Uraushihara; Ryoichi Iiyama; Teruji Totsuka; Kiyoshi Takeda; Shizuo Akira; Mamoru Watanabe
MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis.
Journal of gastroenterology 2005;40(1):16-23.
2004: Takanori Kanai; Mamoru Watanabe
[Regulatory T cells and inflammatory bowel diseases].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2004;27(5):302-8.
2004: Takeshi Nagamatsu; Tomoyuki Fujii; Takahiro Yamashita; Akinori Miki; Takanori Kanai; Maki Kusumi; Yutaka Osuga; Shiro Kozuma; Yuji Taketani
Hypoxia does not reduce HLA-G expression on extravillous cytotrophoblasts.
Journal of reproductive immunology 2004;63(2):85-95.
2004: Shin Makita; Takanori Kanai; Shigeru Oshima; Koji Uraushihara; Teruji Totsuka; Taisuke Sawada; Tetsuya Nakamura; Kazutaka Koganei; Tsuneo Fukushima; Mamoru Watanabe
CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3119-30.
2004: Katsuyoshi Matsuoka; Nagamu Inoue; Toshiro Sato; Susumu Okamoto; Tadakazu Hisamatsu; Y Kishi; Atsushi Sakuraba; Osamu Hitotsumatsu; Haruhiko Ogata; K Koganei; T Fukushima; Takanori Kanai; Masahiko Watanabe; Hiromasa Ishii; Toshifumi Hibi
T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease.
Gut 2004;53(9):1303-8.
2004: Akinori Miki; Tomoyuki Fujii; Hiroyuki Yoshikawa; Hironobu Hyodo; Takanori Kanai; Takahiro Yamashita; Toshiharu Yasugi; Shiro Kozuma; Yuji Taketani
A novel method of preoperative autologous blood donation with a large volume of plasma for surgery in gynecologic malignancies.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2004;31(1):21-8.
2004: Shigeru Oshima; Tetsuya Nakamura; Shin Namiki; Eriko Okada; Kiichiro Tsuchiya; Ryuichi Okamoto; Motomi Yamazaki; Takanori Yokota; Masatoshi Aida; Yuki Yamaguchi; Takanori Kanai; Hiroshi Handa; Mamoru Watanabe
Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.
Molecular and cellular biology 2004;24(14):6298-310.
2004: Norio Maeda; Mamoru Watanabe; Susumu Okamoto; Takanori Kanai; Taketo Yamada; Jun-Ichi Hata; Nobumichi Hozumi; Asao Katsume; Hideko Nuriya; Jasbir Sandhu; Hiromasa Ishii; Michinori Kohara; Toshifumi Hibi
Hepatitis C virus infection in human liver tissue engrafted in mice with an infectious molecular clone.
Liver international : official journal of the International Association for the Study of the Liver 2004;24(3):259-67.
2004: Takahiro Kawamura; Takanori Kanai; Taeko Dohi; Koji Uraushihara; Teruji Totsuka; Ryoichi Iiyama; Chikara Taneda; Motomi Yamazaki; Tetsuya Nakamura; Tetsuya Higuchi; Yuichi Aiba; Takeshi Tsubata; Mamoru Watanabe
Ectopic CD40 ligand expression on B cells triggers intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6388-97.
2004: Akira Okazawa; Takanori Kanai; K Nakamaru; Toshiro Sato; Nagamu Inoue; Haruhiko Ogata; Yasushi Iwao; M Ikeda; T Kawamura; Shin Makita; Koji Uraushihara; Ryuichi Okamoto; Motomi Yamazaki; M Kurimoto; Hiromasa Ishii; Masahiko Watanabe; Toshifumi Hibi
Human intestinal epithelial cell-derived interleukin (IL)-18, along with IL-2, IL-7 and IL-15, is a potent synergistic factor for the proliferation of intraepithelial lymphocytes.
Clinical and experimental immunology 2004;136(2):269-76.
2004: Toshiro Sato; Takanori Kanai; Mamoru Watanabe; Atsushi Sakuraba; Susumu Okamoto; Takaaki Nakai; Akira Okazawa; Nagamu Inoue; Teruji Totsuka; Motomi Yamazaki; Richard A Kroczek; Tsuneo Fukushima; Hiromasa Ishii; Toshifumi Hibi
Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease.
Gastroenterology 2004;126(3):829-39.
2004: Takeshi Nagamatsu; Tomoyuki Fujii; T Ishikawa; Takanori Kanai; Hironobu Hyodo; Tetsuji Yamashita; Yutaka Osuga; Mikio Momoeda; Shiro Kozuma; Yuji Taketani
A primary cell culture system for human cytotrophoblasts of proximal cytotrophoblast cell columns enabling in vitro acquisition of the extra-villous phenotype.
Placenta 2004;25(2-3):153-65.
2004: Kenichi Ishii; Takanori Kanai; Teruji Totsuka; Koji Uraushihara; Takahiro Ishikura; Motomi Yamazaki; Ryuichi Okamoto; Akihiro Araki; Tatsuya Miyata; Katsunari Tezuka; Tetsuya Nakamura; Mamoru Watanabe
Hyperexpression of inducible costimulator on lamina propria mononuclear cells in rat dextran sulfate sodium colitis.
Journal of gastroenterology and hepatology 2004;19(2):174-81.
2003: Takanori Kanai; Tomoyuki Fujii; Shiro Kozuma; Akinori Miki; Takahiro Yamashita; Hironobu Hyodo; Nobuya Unno; Shiro Yoshida; Yuji Taketani
A subclass of soluble HLA-G1 modulates the release of cytokines from mononuclear cells present in the decidua additively to membrane-bound HLA-G1.
Journal of reproductive immunology 2003;60(2):85-96.
2003: Ryoichi Iiyama; Takanori Kanai; Koji Uraushihara; Takahiro Ishikura; Shin Makita; Teruji Totsuka; Motomi Yamazaki; Tetsuya Nakamura; Tatsuya Miyata; Hideo Yoshida; O Takeuchi; K Hoshino; Kiyoshi Takeda; Hiromichi Ishikawa; Shizuo Akira; Masahiko Watanabe
Normal development of the gut-associated lymphoid tissue except Peyer's patch in MyD88-deficient mice.
Scandinavian journal of immunology 2003;58(6):620-7.
2003: Takanori Kanai; Teruji Totsuka; Koji Uraushihara; Shin Makita; Tetsuya Nakamura; Kazutaka Koganei; Tsuneo Fukushima; Hisaya Akiba; Hideo Yagita; Ko Okumura; Utako Machida; Hideyuki Iwai; Miyuki Azuma; Lieping Chen; Mamoru Watanabe
Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4156-63.
2003: Shin Makita; Takanori Kanai; S Matsumoto; Ryoichi Iiyama; Koji Uraushihara; Teruji Totsuka; Motomi Yamazaki; Tetsuya Nakamura; Hiromichi Ishikawa; Masahiko Watanabe
The role of cryptopatch-derived intraepithelial lymphocytes in the development of chronic ileocecitis.
Scandinavian journal of immunology 2003;58(4):428-35.
2003: N Dan; Takanori Kanai; Teruji Totsuka; Ryoichi Iiyama; Motomi Yamazaki; Tokihiko Sawada; Tatsuya Miyata; Hideo Yagita; Ko Okumura; Masahiko Watanabe
Ameliorating effect of anti-Fas ligand MAb on wasting disease in murine model of chronic colitis.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(4):G754-60.
2003: H Takagi; Takanori Kanai; Akira Okazawa; Y Kishi; Toshiro Sato; Hiromasa Takaishi; Nagamu Inoue; Haruhiko Ogata; Yasushi Iwao; K Hoshino; Kiyoshi Takeda; Shizuo Akira; Masahiko Watanabe; Hiromasa Ishii; Toshifumi Hibi
Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice.
Scandinavian journal of gastroenterology 2003;38(8):837-44.
2003: Motomi Yamazaki; Tomoharu Yajima; Masanobu Tanabe; Kazuto Fukui; Eriko Okada; Ryuichi Okamoto; Shigeru Oshima; Tetsuya Nakamura; Takanori Kanai; Masahiro Uehira; Tsutomu Takeuchi; Hiromichi Ishikawa; Toshifumi Hibi; Mamoru Watanabe
Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1556-63.
2003: Takahiro Ishikura; Takanori Kanai; Koji Uraushihara; Ryoichi Iiyama; Shin Makita; Teruji Totsuka; Motomi Yamazaki; Taisuke Sawada; Tetsuya Nakamura; Tatsuya Miyata; Tetsuji Kitahora; Toshifumi Hibi; Tomoaki Hoshino; Mamoru Watanabe
Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice.
Journal of gastroenterology and hepatology 2003;18(8):960-9.
2003: Koji Uraushihara; Takanori Kanai; Kwibeom Ko; Teruji Totsuka; Shin Makita; Ryoichi Iiyama; Tetsuya Nakamura; Mamoru Watanabe
Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):708-16.
2003: Ryoichi Iiyama; Takanori Kanai; Koji Uraushihara; Teruji Totsuka; Tetsuya Nakamura; Tatsuya Miyata; Hideo Yagita; A Kushi; K Suzuki; Katsunari Tezuka; Masahiko Watanabe
The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches.
Immunology letters 2003;88(1):63-70.
2003: Toshihiko Ezaki; Mamoru Watanabe; Nagamu Inoue; Takanori Kanai; Haruhiko Ogata; Yasushi Iwao; Hiromasa Ishii; Toshifumi Hibi
A specific genetic alteration on chromosome 6 in ulcerative colitis-associated colorectal cancers.
Cancer research 2003;63(13):3747-9.
2003: Takanori Kanai; Koji Uraushihara; Teruji Totsuka; Akira Okazawa; Toshifumi Hibi; Shigeru Oshima; Tatsuya Miyata; Tetsuya Nakamura; Mamoru Watanabe
Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.
Current drug targets. Inflammation and allergy 2003;2(2):131-6.
2003: Mamoru Watanabe; Motomi Yamazaki; Ryuichi Okamoto; Shinya Ohoka; Akihiro Araki; Tetsuya Nakamura; Takanori Kanai
Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway.
Current drug targets. Inflammation and allergy 2003;2(2):119-23.
2003: Teruji Totsuka; Takanori Kanai; Koji Uraushihara; Ryoichi Iiyama; Motomi Yamazaki; Hisaya Akiba; Hideo Yagita; Ko Okumura; Masahiko Watanabe
Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(4):G595-603.
2003: Mamoru Watanabe; Motomi Yamazaki; Takanori Kanai
Mucosal T cells as a target for treatment of IBD.
Journal of gastroenterology 2003;38 Suppl 15():48-50.
2003: Teruji Totsuka; Takanori Kanai; Ryoichi Iiyama; Koji Uraushihara; Motomi Yamazaki; Ryuichi Okamoto; Toshifumi Hibi; Katsunari Tezuka; Miyuki Azuma; Hisaya Akiba; Hideo Yagita; Ko Okumura; Mamoru Watanabe
Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis.
Gastroenterology 2003;124(2):410-21.
2002: Akira Okazawa; Takanori Kanai; Mamoru Watanabe; Motomi Yamazaki; Nagamu Inoue; Masao Ikeda; Masashi Kurimoto; Hiromasa Ishii; Toshifumi Hibi
Th1-mediated intestinal inflammation in Crohn's disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of interleukin-12 and interleukin-18 without T cell receptor engagement.
The American journal of gastroenterology 2002;97(12):3108-17.
2002: Takanori Kanai; Teruji Totsuka; Katsunari Tezuka; Mamoru Watanabe
ICOS costimulation in inflammatory bowel disease.
Journal of gastroenterology 2002;37 Suppl 14():78-81.
2002: Takanori Kanai; Ryoichi Ilyama; Takahiro Ishikura; Koji Uraushihara; Teruji Totsuka; Motomi Yamazaki; Tetsuya Nakamuma; Mamoru Watanabe
Role of the innate immune system in the development of chronic colitis.
Journal of gastroenterology 2002;37 Suppl 14():38-42.
2002: Ryuichi Okamoto; Tomoharu Yajima; Motomi Yamazaki; Takanori Kanai; Makio Mukai; Shinichiro Okamoto; Yasuo Ikeda; Toshifumi Hibi; Johji Inazawa; Mamoru Watanabe
Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract.
Nature medicine 2002;8(9):1011-7.
2002: Makoto Naganuma; Mamoru Watanabe; Takanori Kanai; Yasushi Iwao; Makio Mukai; Hiromasa Ishii; Toshifumi Hibi
Characterization of structures with T-lymphocyte aggregates in ileal villi of Crohn's disease.
The American journal of gastroenterology 2002;97(7):1741-7.
2001: O Fujii; Takanori Kanai; S Kouzuma; K Baba; Akinori Miki; Hironobu Hyodo; Tetsuji Yamashita; Nobuya Unno; Yuji Taketani
Herbal medicines, Sairei-to and Tokishakuyaku-san, differently modulate the release of cytokines from decidual versus peripheral blood mononuclear cells.
American journal of reproductive immunology (New York, N.Y. : 1989) 2001;46(5):369-72.
2001: Takanori Kanai; Masahiko Watanabe; Akira Okazawa; Toshiro Sato; Motomi Yamazaki; Shinichiro Okamoto; Hiromasa Ishii; Teruji Totsuka; Ryoichi Iiyama; Ryuichi Okamoto; M Ikeda; M Kurimoto; Kiyoshi Takeda; Shizuo Akira; Toshifumi Hibi
Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease.
Gastroenterology 2001;121(4):875-88.
2001: Nagamu Inoue; Masahiko Watanabe; Toshiro Sato; Akira Okazawa; Motomi Yamazaki; Takanori Kanai; Haruhiko Ogata; Yasushi Iwao; Hiromasa Ishii; Toshifumi Hibi
Restricted V(H) gene usage in lamina propria B cells producing anticolon antibody from patients with ulcerative colitis.
Gastroenterology 2001;121(1):15-23.
2001: Takanori Kanai; Tomoyuki Fujii; Naoto Keicho; K Tokunaga; Tetsuji Yamashita; Hironobu Hyodo; Akinori Miki; Nobuya Unno; Shiro Kozuma; Yuji Taketani
Polymorphism of human leukocyte antigen-E gene in the Japanese population with or without recurrent abortion.
American journal of reproductive immunology (New York, N.Y. : 1989) 2001;45(3):168-73.
2001: Takanori Kanai; Tomoyuki Fujii; Nobuya Unno; Tetsuji Yamashita; Hironobu Hyodo; Akinori Miki; Y Hamai; Shiro Kozuma; Yuji Taketani
Human leukocyte antigen-G-expressing cells differently modulate the release of cytokines from mononuclear cells present in the decidua versus peripheral blood.
American journal of reproductive immunology (New York, N.Y. : 1989) 2001;45(2):94-9.
2001: Takanori Kanai; Masahiko Watanabe; Akira Okazawa; Toshiro Sato; Toshifumi Hibi
Interleukin-18 and Crohn's disease.
Digestion 2001;63 Suppl 1():37-42.
2000: Toshifumi Hibi; Takanori Kanai; Masahiko Watanabe; S Okazawa; Toshiro Sato
[The role of IL-18 on the pathogenesis of Crohn's disease].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2000;23(6):607-10.
2000: Tomoyuki Fujii; Takanori Kanai; Shiro Kozuma; Y Hamai; Hironobu Hyodo; Tetsuji Yamashita; Akinori Miki; Nobuya Unno; Yuji Taketani
Theoretical basis for herbal medicines, Tokishakuyaku-san and Sairei-to, in the treatment of autoimmunity-related recurrent abortion by correcting T helper-1/T helper-2 balance.
American journal of reproductive immunology (New York, N.Y. : 1989) 2000;44(6):342-6.
2000: Takanori Kanai; Masahiko Watanabe; Akira Okazawa; K Nakamaru; M Okamoto; M Naganuma; Hiromasa Ishii; M Ikeda; M Kurimoto; Toshifumi Hibi
Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease.
Gastroenterology 2000;119(6):1514-23.
2000: Makoto Naganuma; Yasushi Iwao; Nagamu Inoue; Tadakazu Hisamatsu; Hiroyuki Imaeda; Hiromasa Ishii; Takanori Kanai; Masahiko Watanabe; Toshifumi Hibi
Analysis of clinical course and long-term prognosis of surgical and nonsurgical patients with intestinal Behçet's disease.
The American journal of gastroenterology 2000;95(10):2848-51.
2000: K Kashiwagi; Masahiko Watanabe; T Ezaki; Takanori Kanai; Hiromasa Ishii; Makio Mukai; Toshifumi Hibi
Clinical usefulness of microsatellite instability for the prediction of gastric adenoma or adenocarcinoma in patients with chronic gastritis.
British journal of cancer 2000;82(11):1814-8.
2000: Takanori Kanai; Masahiko Watanabe; A Hayashi; A Nakazawa; T Yajima; Akira Okazawa; Motomi Yamazaki; Hiromasa Ishii; Toshifumi Hibi
Regulatory effect of interleukin-4 and interleukin-13 on colon cancer cell adhesion.
British journal of cancer 2000;82(10):1717-23.
2000: Hiromasa Takaishi; S Ohara; Kyoko Hotta; Tomoharu Yajima; Takanori Kanai; Nagamu Inoue; Yasushi Iwao; Masahiko Watanabe; Hiromasa Ishii; Toshifumi Hibi
Circulating autoantibodies against purified colonic mucin in ulcerative colitis.
Journal of gastroenterology 2000;35(1):20-7.
1999: Tadakazu Hisamatsu; Mamoru Watanabe; Haruhiko Ogata; T Ezaki; S Hozawa; Hiromasa Ishii; Takanori Kanai; Toshifumi Hibi
Interferon-inducible gene family 1-8U expression in colitis-associated colon cancer and severely inflamed mucosa in ulcerative colitis.
Cancer research 1999;59(23):5927-31.
1999: A Nakazawa; Masahiko Watanabe; Takanori Kanai; Tomoharu Yajima; Motomi Yamazaki; Haruhiko Ogata; Hiromasa Ishii; M Azuma; Toshifumi Hibi
Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa.
Gastroenterology 1999;117(3):536-45.
1999: Makoto Naganuma; Yasushi Iwao; Soichiro Miura; I Okamoto; Y Ohkura; Takanori Kanai; Masahiko Watanabe; Toshifumi Hibi; Hiromasa Ishii
[A case of well differentiated adenocarcinoma with ulcerative colitis resembling colitis cystica profunda].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 1999;96(6):658-63.
1998: T Yajima; H Takaishi; Takanori Kanai; Yasushi Iwao; Mamoru Watanabe; Hiromasa Ishii; Toshifumi Hibi
Predictive factors of response to leukocytapheresis therapy for ulcerative colitis.
Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis 1998;2(2):115-9.
1997: Masahiko Watanabe; N Watanabe; Y Iwao; H Ogata; Takanori Kanai; Y Ueno; M Tsuchiya; Hiromasa Ishii; S Aiso; S Habu; Toshifumi Hibi
The serum factor from patients with ulcerative colitis that induces T cell proliferation in the mouse thymus is interleukin-7.
Journal of clinical immunology 1997;17(4):282-92.
1993: Toshifumi Hibi; M Ohara; M Watanabe; Takanori Kanai; H Takaishi; A Hayashi; Y Hosoda; H Ogata; Yasushi Iwao; S Aiso
Interleukin 2 and interferon-gamma augment anticolon antibody dependent cellular cytotoxicity in ulcerative colitis.
Gut 1993;34(6):788-93.
1990: H Serizawa; Toshifumi Hibi; H Niwa; H Tashiro; Takanori Kanai; Soichiro Miura; Y Sugino; Y Tashiro; M Tsuchiya
[A case of enterocolitis with diffuse multiple aphthoid lesions in which non-caseous granulomas were demonstrated microscopically].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 1990;87(8):1701-5.
1989: M Watanabe; Toshifumi Hibi; Yasushi Iwao; Takanori Kanai; M Ohara; T Fujisawa; H Ogata; N Watanabe; H Asakura; S Aiso
Release of the serum immunosuppressive factor by monocytes in patients with Crohn's disease.
Journal of clinical & laboratory immunology 1989;29(4):161-6.