Shigenori Kanaya

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Tanaka Shun-ichi; Matsumura Hiroyoshi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Identification of the interactions critical for propeptide-catalyzed folding of Tk-subtilisin.
Budiman Cahyo; Bando Keisuke; Angkawidjaja Clement; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Engineering of monomeric FK506-binding protein 22 with peptidyl prolyl cis-trans isomerase. Importance of a V-shaped dimeric structure for binding to protein substrate.
Tadokoro Takashi; Kanaya Shigenori
Ribonuclease H: molecular diversities, substrate binding domains, and catalytic mechanism of the prokaryotic enzymes.

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All Publications

2009: Tanaka Shun-ichi; Matsumura Hiroyoshi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Identification of the interactions critical for propeptide-catalyzed folding of Tk-subtilisin.
Journal of molecular biology 2009;394(2):306-19.
2009: Budiman Cahyo; Bando Keisuke; Angkawidjaja Clement; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Engineering of monomeric FK506-binding protein 22 with peptidyl prolyl cis-trans isomerase. Importance of a V-shaped dimeric structure for binding to protein substrate.
The FEBS journal 2009;276(15):4091-101.
2009: Tadokoro Takashi; Kanaya Shigenori
Ribonuclease H: molecular diversities, substrate binding domains, and catalytic mechanism of the prokaryotic enzymes.
The FEBS journal 2009;276(6):1482-93.
2009: Rohman Muhammad S; Tadokoro Takashi; Angkawidjaja Clement; Abe Yumi; Matsumura Hiroyoshi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Destabilization of psychrotrophic RNase HI in a localized fashion as revealed by mutational and X-ray crystallographic analyses.
The FEBS journal 2009;276(2):603-13.
2009: Kato Tomohisa; Miyanaga Asuka; Kanaya Shigenori; Morikawa Masaaki
Alkane inducible proteins in Geobacillus thermoleovorans B23.
BMC microbiology 2009;9():60.
2008: Tanaka Shun-ichi; Takeuchi Yuki; Matsumura Hiroyoshi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Crystal structure of Tk-subtilisin folded without propeptide: requirement of propeptide for acceleration of folding.
FEBS letters 2008;582(28):3875-8.
2008: Rohman Muhammad S; Koga Yuichi; Takano Kazufumi; Chon Hyongi; Crouch Robert J; Kanaya Shigenori
Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII.
The FEBS journal 2008;275(19):4836-49.
2008: Tadokoro Takashi; Matsushita Kyoko; Abe Yumi; Rohman Muhammad Saifur; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Remarkable stabilization of a psychrotrophic RNase HI by a combination of thermostabilizing mutations identified by the suppressor mutation method.
Biochemistry 2008;47(31):8040-7.
2008: Koga Yuichi; Katsumi Ryota; You Dong-Ju; Matsumura Hiroyoshi; Takano Kazufumi; Kanaya Shigenori
Crystal structure of highly thermostable glycerol kinase from a hyperthermophilic archaeon in a dimeric form.
The FEBS journal 2008;275(10):2632-43.
2008: Dong Hongju; Mukaiyama Atsushi; Tadokoro Takashi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Hydrophobic effect on the stability and folding of a hyperthermophilic protein.
Journal of molecular biology 2008;378(1):264-72.
2008: Mukaiyama Atsushi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Osmolyte effect on the stability and folding of a hyperthermophilic protein.
Proteins 2008;71(1):110-8.
2007: Pulido Marian A; Tanaka Shun-ichi; Sringiew Chutima; You Dong-Ju; Matsumura Hiroyoshi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Requirement of left-handed glycine residue for high stability of the Tk-subtilisin propeptide as revealed by mutational and crystallographic analyses.
Journal of molecular biology 2007;374(5):1359-73.
2007: Angkawidjaja Clement; You Dong-ju; Matsumura Hiroyoshi; Kuwahara Katsumasa; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Crystal structure of a family I.3 lipase from Pseudomonas sp. MIS38 in a closed conformation.
FEBS letters 2007;581(26):5060-4.
2007: You Dong-Ju; Chon Hyongi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Crystal structure of type 1 ribonuclease H from hyperthermophilic archaeon Sulfolobus tokodaii: role of arginine 118 and C-terminal anchoring.
Biochemistry 2007;46(41):11494-503.
2007: You Dong-Ju; Fukuchi Satoshi; Nishikawa Ken; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Protein thermostabilization requires a fine-tuned placement of surface-charged residues.
Journal of biochemistry 2007;142(4):507-16.
2007: Tanaka Shun-Ichi; Matsumura Hiroyoshi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Four new crystal structures of Tk-subtilisin in unautoprocessed, autoprocessed and mature forms: insight into structural changes during maturation.
Journal of molecular biology 2007;372(4):1055-69.
2007: Takano Kazufumi; Katagiri Yoshiaki; Mukaiyama Atsushi; Chon Hyongi; Matsumura Hiroyoshi; Koga Yuichi; Kanaya Shigenori
Conformational contagion in a protein: structural properties of a chameleon sequence.
Proteins 2007;68(3):617-25.
2007: Tadokoro Takashi; Chon Hyongi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Identification of the gene encoding a type 1 RNase H with an N-terminal double-stranded RNA binding domain from a psychrotrophic bacterium.
The FEBS journal 2007;274(14):3715-27.
2007: Tadokoro Takashi; You Dong-Ju; Abe Yumi; Chon Hyongi; Matsumura Hiroyoshi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Structural, thermodynamic, and mutational analyses of a psychrotrophic RNase HI.
Biochemistry 2007;46(25):7460-8.
2007: Pulido M A; Koga Y; Takano K; Kanaya S
Directed evolution of Tk-subtilisin from a hyperthermophilic archaeon: identification of a single amino acid substitution responsible for low-temperature adaptation.
Protein engineering, design & selection : PEDS 2007;20(3):143-53.
2007: Angkawidjaja Clement; You Dong-Ju; Matsumura Hiroyoshi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Extracellular overproduction and preliminary crystallographic analysis of a family I.3 lipase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 3):187-9.
2007: Tanaka Shun-ichi; Saito Kenji; Chon Hyongi; Matsumura Hiroyoshi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Crystal structure of unautoprocessed precursor of subtilisin from a hyperthermophilic archaeon: evidence for Ca2+-induced folding.
The Journal of biological chemistry 2007;282(11):8246-55.
2007: Katsumi Ryota; Koga Yuichi; You Dong-Ju; Matsumura Hiroyoshi; Takano Kazufumi; Kanaya Shigenori
Crystallization and preliminary X-ray diffraction study of glycerol kinase from the hyperthermophilic archaeon Thermococcus kodakaraensis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 2):126-9.
2007: Hirano Shin-ichi; Morikawa Masaaki; Takano Kazufumi; Imanaka Tadayuki; Kanaya Shigenori
Gentisate 1,2-dioxygenase from Xanthobacter polyaromaticivorans 127W.
Bioscience, biotechnology, and biochemistry 2007;71(1):192-9.
2007: Wada Takehiko; Maeda Yoshiki; Sawa Nobuya; Sato Hirofumi; Chon Hyongi; Kanaya Shigenori; Inoue Yoshihisa
Synthesis of peptide ribonucleic acid (PRNA)-DNA chimera and interaction with DNA and RNA.
Nucleic acids symposium series (2004) 2007;(51):21-2.
2006: Angkawidjaja C; Kanaya S
Family I.3 lipase: bacterial lipases secreted by the type I secretion system.
Cellular and molecular life sciences : CMLS 2006;63(23):2804-17.
2006: Kashii Masafumi; Fujisawa Ryo; Adachi Hiroaki; Mori Yusuke; Sasaki Takatomo; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori; Matsumura Hiroyoshi; Inoue Tsuyoshi; Murakami Satoshi; Sugamoto Kazuomi; Yoshikawa Hideki
Application of femtosecond laser ablation for detaching grown protein crystals from glass capillary tube.
Journal of bioscience and bioengineering 2006;102(4):372-4.
2006: Mukaiyama Atsushi; Haruki Mitsuru; Ota Motonori; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
A hyperthermophilic protein acquires function at the cost of stability.
Biochemistry 2006;45(42):12673-9.
2006: Tanaka Shun-ichi; Saito Kenji; Chon Hyongi; Matsumura Hiroyoshi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Crystallization and preliminary X-ray diffraction study of an active-site mutant of pro-Tk-subtilisin from a hyperthermophilic archaeon.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 9):902-5.
2006: Morikawa Masaaki; Kagihiro Shinji; Haruki Mitsuru; Takano Kazufumi; Branda Steve; Kolter Roberto; Kanaya Shigenori
Biofilm formation by a Bacillus subtilis strain that produces gamma-polyglutamate.
Microbiology (Reading, England) 2006;152(Pt 9):2801-7.
2006: Thaniyavarn Jiraporn; Chongchin Aree; Wanitsuksombut Nopparat; Thaniyavarn Suthep; Pinphanichakarn Pairoh; Leepipatpiboon Natthanant; Morikawa Masaaki; Kanaya Shigenori
Biosurfactant production by Pseudomonas aeruginosa A41 using palm oil as carbon source.
The Journal of general and applied microbiology 2006;52(4):215-22.
2006: You Dong Ju; Chon Hyongi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Crystallization and preliminary crystallographic analysis of type 1 RNase H from the hyperthermophilic archaeon Sulfolobus tokodaii 7.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 8):781-4.
2006: Angkawidjaja C; Kuwahara K; Omori K; Koga Y; Takano K; Kanaya S
Extracellular secretion of Escherichia coli alkaline phosphatase with a C-terminal tag by type I secretion system: purification and biochemical characterization.
Protein engineering, design & selection : PEDS 2006;19(7):337-43.
2006: Pulido Marian; Saito Kenji; Tanaka Shun-Ichi; Koga Yuichi; Morikawa Masaaki; Takano Kazufumi; Kanaya Shigenori
Ca2+-dependent maturation of subtilisin from a hyperthermophilic archaeon, Thermococcus kodakaraensis: the propeptide is a potent inhibitor of the mature domain but is not required for its folding.
Applied and environmental microbiology 2006;72(6):4154-62.
2006: Chon Hyongi; Tadokoro Takashi; Ohtani Naoto; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Identification of RNase HII from psychrotrophic bacterium, Shewanella sp. SIB1 as a high-activity type RNase H.
The FEBS journal 2006;273(10):2264-75.
2006: Cornista Joel C; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Amyloidogenecity and pitrilysin sensitivity of a lysine-free derivative of amyloid beta-peptide cleaved from a recombinant fusion protein.
Journal of biotechnology 2006;122(2):186-97.
2006: Chon Hyongi; Matsumura Hiroyoshi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Crystal structure and structure-based mutational analyses of RNase HIII from Bacillus stearothermophilus: a new type 2 RNase H with TBP-like substrate-binding domain at the N terminus.
Journal of molecular biology 2006;356(1):165-78.
2006: Hirano Shin-Ichi; Haruki Mitsuru; Takano Kazufumi; Imanaka Tadayuki; Morikawa Masaaki; Kanaya Shigenori
Gene cloning and in vivo characterization of a dibenzothiophene dioxygenase from Xanthobacter polyaromaticivorans.
Applied microbiology and biotechnology 2006;69(6):672-81.
2006: Takano Kazufumi; Endo Shuji; Mukaiyama Atsushi; Chon Hyongi; Matsumura Hiroyoshi; Koga Yuichi; Kanaya Shigenori
Structure of amyloid beta fragments in aqueous environments.
The FEBS journal 2006;273(1):150-8.
2006: Yamamoto Takahiko; Matsuda Tomoki; Inoue Tsuyoshi; Matsumura Hiroyoshi; Morikawa Masaaki; Kanaya Shigenori; Kai Yasushi
Crystal structure of TBP-interacting protein (Tk-TIP26) and implications for its inhibition mechanism of the interaction between TBP and TATA-DNA.
Protein science : a publication of the Protein Society 2006;15(1):152-61.
2005: Roongsawang Niran; Lim Siew Ping; Washio Kenji; Takano Kazufumi; Kanaya Shigenori; Morikawa Masaaki
Phylogenetic analysis of condensation domains in the nonribosomal peptide synthetases.
FEMS microbiology letters 2005;252(1):143-51.
2005: Chon Hyongi; Matsumura Hiroyoshi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Crystal structure of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3 at 2.20 A resolution.
Proteins 2005;61(3):685-8.
2005: Suzuki Yutaka; Win Ohnmar Ye; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Binding analysis of a psychrotrophic FKBP22 to a folding intermediate of protein using surface plasmon resonance.
FEBS letters 2005;579(25):5781-4.
2005: Angkawidjaja Clement; Paul Aditya; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Importance of a repetitive nine-residue sequence motif for intracellular stability and functional structure of a family I.3 lipase.
FEBS letters 2005;579(21):4707-12.
2005: Chon Hyongi; Matsumura Hiroyoshi; Shimizu Shoko; Maeda Nao; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Overproduction and preliminary crystallographic study of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 3):319-22.
2005: Chon Hyongi; Matsumura Hiroyoshi; Koga Yuichi; Takano Kazufumi; Kanaya Shigenori
Crystallization and preliminary X-ray diffraction study of thermostable RNase HIII from Bacillus stearothermophilus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 3):293-5.
2005: Suzuki Yutaka; Mizutani Yoichi; Tsuji Tadao; Ohtani Naoto; Takano Kazufumi; Haruki Mitsuru; Morikawa Masaaki; Kanaya Shigenori
Gene cloning, overproduction, and characterization of thermolabile alkaline phosphatase from a psychrotrophic bacterium.
Bioscience, biotechnology, and biochemistry 2005;69(2):364-73.
2005: Suzuki Yutaka; Takano Kazufumi; Kanaya Shigenori
Stabilities and activities of the N- and C-domains of FKBP22 from a psychrotrophic bacterium overproduced in Escherichia coli.
The FEBS journal 2005;272(3):632-42.
2005: Tsunaka Yasuo; Takano Kazufumi; Matsumura Hiroyoshi; Yamagata Yuriko; Kanaya Shigenori
Identification of single Mn(2+) binding sites required for activation of the mutant proteins of E.coli RNase HI at Glu48 and/or Asp134 by X-ray crystallography.
Journal of molecular biology 2005;345(5):1171-83.
2005: Kunihiro Namio; Haruki Mitsuru; Takano Kazufumi; Morikawa Masaaki; Kanaya Shigenori
Isolation and characterization of Rhodococcus sp. strains TMP2 and T12 that degrade 2,6,10,14-tetramethylpentadecane (pristane) at moderately low temperatures.
Journal of biotechnology 2005;115(2):129-36.
2004: Mukaiyama Atsushi; Takano Kazufumi; Haruki Mitsuru; Morikawa Masaaki; Kanaya Shigenori
Kinetically robust monomeric protein from a hyperthermophile.
Biochemistry 2004;43(43):13859-66.
2004: Chon Hyongi; Nakano Rikita; Ohtani Naoto; Haruki Mitsuru; Takano Kazufumi; Morikawa Masaaki; Kanaya Shigenori
Gene cloning and biochemical characterizations of thermostable ribonuclease HIII from Bacillus stearothermophilus.
Bioscience, biotechnology, and biochemistry 2004;68(10):2138-47.
2004: Cornista Joel; Ikeuchi Satoshi; Haruki Mitsuru; Kohara Atsuko; Takano Kazufumi; Morikawa Masaaki; Kanaya Shigenori
Cleavage of various peptides with pitrilysin from Escherichia coli: kinetic analyses using beta-endorphin and its derivatives.
Bioscience, biotechnology, and biochemistry 2004;68(10):2128-37.
2004: Takano Kazufumi; Saito Minoru; Morikawa Masaaki; Kanaya Shigenori
Mutational and structural-based analyses of the osmolyte effect on protein stability.
Journal of biochemistry 2004;135(6):701-8.
2004: Suzuki Yutaka; Haruki Mitsuru; Takano Kazufumi; Morikawa Masaaki; Kanaya Shigenori
Possible involvement of an FKBP family member protein from a psychrotrophic bacterium Shewanella sp. SIB1 in cold-adaptation.
European journal of biochemistry / FEBS 2004;271(7):1372-81.
2004: Hirano Shin-ichi; Kitauchi Fumiya; Haruki Mitsuru; Imanaka Tadayuki; Morikawa Masaaki; Kanaya Shigenori
Isolation and characterization of Xanthobacter polyaromaticivorans sp. nov. 127W that degrades polycyclic and heterocyclic aromatic compounds under extremely low oxygen conditions.
Bioscience, biotechnology, and biochemistry 2004;68(3):557-64.
2003: Roongsawang Niran; Hase Ken ichi; Haruki Mitsuru; Imanaka Tadayuki; Morikawa Masaaki; Kanaya Shigenori
Cloning and characterization of the gene cluster encoding arthrofactin synthetase from Pseudomonas sp. MIS38.
Chemistry & biology 2003;10(9):869-80.
2003: Thaniyavarn Jiraporn; Roongsawang Niran; Kameyama Takayuki; Haruki Mitsuru; Imanaka Tadayuki; Morikawa Masaaki; Kanaya Shigenori
Production and characterization of biosurfactants from Bacillus licheniformis F2.2.
Bioscience, biotechnology, and biochemistry 2003;67(6):1239-44.
2003: Yamasaki Kazuhiko; Yamasaki Tomoko; Kanaya Shigenori; Oobatake Motohisa
Acid-induced denaturation of Escherichia coli ribonuclease HI analyzed by CD and NMR spectroscopies.
Biopolymers 2003;69(2):176-88.
2003: Tsunaka Yasuo; Haruki Mitsuru; Morikawa Masaaki; Oobatake Motohisa; Kanaya Shigenori
Dispensability of glutamic acid 48 and aspartic acid 134 for Mn2+-dependent activity of Escherichia coli ribonuclease HI.
Biochemistry 2003;42(11):3366-74.
2003: Yamamoto Takahiko; Matsuda Tomoki; Sakamoto Nami; Matsumura Hiroyoshi; Inoue Tsuyoshi; Morikawa Masaaki; Kanaya Shigenori; Kai Yasushi
Crystallization and preliminary X-ray analysis of TBP-interacting protein from the hyperthermophilic archaeon Thermococcus kodakaraensis strain KOD1.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 2):372-4.
2003: Adachi Hiroaki; Takano Kazufumi; Morikawa Masaaki; Kanaya Shigenori; Yoshimura Masashi; Mori Yusuke; Sasaki Takatomo
Application of a two-liquid system to sitting-drop vapour-diffusion protein crystallization.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 1):194-6.
2002: Roongsawang Niran; Thaniyavarn Jiraporn; Thaniyavarn Suthep; Kameyama Takayuki; Haruki Mitsuru; Imanaka Tadayuki; Morikawa Masaaki; Kanaya Shigenori
Isolation and characterization of a halotolerant Bacillus subtilis BBK-1 which produces three kinds of lipopeptides: bacillomycin L, plipastatin, and surfactin.
Extremophiles : life under extreme conditions 2002;6(6):499-506.
2002: Haruki Mitsuru; Tsunaka Yasuo; Morikawa Masaaki; Kanaya Shigenori
Cleavage of a DNA-RNA-DNA/DNA chimeric substrate containing a single ribonucleotide at the DNA-RNA junction with prokaryotic RNases HII.
FEBS letters 2002;531(2):204-8.
2002: Chon Hyongi; Tsunaka Yasuo; Haruki Mitsuru; Morikawa Masaaki; Kanaya Shigenori
Site-specific cleavage of MS2 RNA by a thermostable DNA-linked RNase H.
Protein engineering 2002;15(8):683-8.
2002: Muroya Ayumu; Nakano Rikita; Ohtani Naoto; Haruki Mitsuru; Morikawa Masaaki; Kanaya Shigenori
Importance of an N-terminal extension in ribonuclease HII from Bacillus stearothermophilus for substrate binding.
Journal of bioscience and bioengineering 2002;93(2):170-5.
2002: Kwon Hyun-Ju; Haruki Mitsuru; Morikawa Masaaki; Omori Kenji; Kanaya Shigenori
Role of repetitive nine-residue sequence motifs in secretion, enzymatic activity, and protein conformation of a family I.3 lipase.
Journal of bioscience and bioengineering 2002;93(2):157-64.
2001: Ohtani N; Haruki M; Morikawa M; Kanaya S
Heat labile ribonuclease HI from a psychrotrophic bacterium: gene cloning, characterization and site-directed mutagenesis.
Protein engineering 2001;14(12):975-82.
2001: Amada K; Kwon H J; Haruki M; Morikawa M; Kanaya S
Ca(2+)-induced folding of a family I.3 lipase with repetitive Ca(2+) binding motifs at the C-terminus.
FEBS letters 2001;509(1):17-21.
2001: Kato T; Haruki M; Imanaka T; Morikawa M; Kanaya S
Isolation and characterization of psychotrophic bacteria from oil-reservoir water and oil sands.
Applied microbiology and biotechnology 2001;55(6):794-800.
2001: Matsuda T; Fujikawa M; Haruki M; Tang X F; Ezaki S; Imanaka T; Morikawa M; Kanaya S
Interaction of TIP26 from a hyperthermophilic archaeon with TFB/TBP/DNA ternary complex.
Extremophiles : life under extreme conditions 2001;5(3):177-82.
2001: Kannan Y; Koga Y; Inoue Y; Haruki M; Takagi M; Imanaka T; Morikawa M; Kanaya S
Active subtilisin-like protease from a hyperthermophilic archaeon in a form with a putative prosequence.
Applied and environmental microbiology 2001;67(6):2445-52.
2001: Tsunaka Y; Haruki M; Morikawa M; Kanaya S
Strong nucleic acid binding to the Escherichia coli RNase HI mutant with two arginine residues at the active site.
Biochimica et biophysica acta 2001;1547(1):135-42.
2001: Muroya A; Tsuchiya D; Ishikawa M; Haruki M; Morikawa M; Kanaya S; Morikawa K
Catalytic center of an archaeal type 2 ribonuclease H as revealed by X-ray crystallographic and mutational analyses.
Protein science : a publication of the Protein Society 2001;10(4):707-14.
2001: Koga Y; Haruki M; Morikawa M; Kanaya S
Stabilities of chimeras of hyperthermophilic and mesophilic glycerol kinases constructed by DNA shuffling.
Journal of bioscience and bioengineering 2001;91(6):551-6.
2001: Kato T; Miyanaga A; Haruki M; Imanaka T; Morikawa M; Kanaya S
Gene Cloning of an alcohol dehydrogenase from thermophilic alkane-degrading Bacillus thermoleovorans B23.
Journal of bioscience and bioengineering 2001;91(1):100-2.
2001: Kato T; Haruki M; Imanaka T; Morikawa M; Kanaya S
Isolation and characterization of long-chain-alkane degrading Bacillus thermoleovorans from deep subterranean petroleum reservoirs.
Journal of bioscience and bioengineering 2001;91(1):64-70.
2001: Kanaya S
Prokaryotic type 2 RNases H.
Methods in enzymology 2001;341():377-94.
2000: Haruki M; Nogawa T; Hirano N; Chon H; Tsunaka Y; Morikawa M; Kanaya S
Efficient cleavage of RNA at high temperatures by a thermostable DNA-linked ribonuclease H.
Protein engineering 2000;13(12):881-6.
2000: Haruki M; Tsunaka Y; Morikawa M; Iwai S; Kanaya S
Catalysis by Escherichia coli ribonuclease HI is facilitated by a phosphate group of the substrate.
Biochemistry 2000;39(45):13939-44.
2000: Hirano N; Haruki M; Morikawa M; Kanaya S
Enhancement of the enzymatic activity of ribonuclease HI from Thermus thermophilus HB8 with a suppressor mutation method.
Biochemistry 2000;39(43):13285-94.
2000: Kwon H J; Amada K; Haruki M; Morikawa M; Kanaya S;
Identification of the histidine and aspartic acid residues essential for enzymatic activity of a family I.3 lipase by site-directed mutagenesis.
FEBS letters 2000;483(2-3):139-42.
2000: Amada K; Haruki M; Imanaka T; Morikawa M; Kanaya S
Overproduction in Escherichia coli, purification and characterization of a family I.3 lipase from Pseudomonas sp. MIS38.
Biochimica et biophysica acta 2000;1478(2):201-10.
2000: Ohtani N; Haruki M; Muroya A; Morikawa M; Kanaya S
Characterization of ribonuclease HII from Escherichia coli overproduced in a soluble form.
Journal of biochemistry 2000;127(5):895-9.
1999: Mizuguchi S; Amada K; Haruki M; Imanaka T; Morikawa M; Kanaya S
Identification of the gene encoding esterase, a homolog of hormone-sensitive lipase, from an oil-degrading bacterium, strain HD-1.
Journal of biochemistry 1999;126(4):731-7.
1999: Matsuda T; Morikawa M; Haruki M; Higashibata H; Imanaka T; Kanaya S
Isolation of TBP-interacting protein (TIP) from a hyperthermophilic archaeon that inhibits the binding of TBP to TATA-DNA.
FEBS letters 1999;457(1):38-42.
1999: Haruki M; Oohashi Y; Mizuguchi S; Matsuo Y; Morikawa M; Kanaya S
Identification of catalytically essential residues in Escherichia coli esterase by site-directed mutagenesis.
FEBS letters 1999;454(3):262-6.
1999: Izumi M; Fujiwara S; Takagi M; Kanaya S; Imanaka T
Isolation and characterization of a second subunit of molecular chaperonin from Pyrococcus kodakaraensis KOD1: analysis of an ATPase-deficient mutant enzyme.
Applied and environmental microbiology 1999;65(4):1801-5.
1999: Ohtani N; Haruki M; Morikawa M; Crouch R J; Itaya M; Kanaya S
Identification of the genes encoding Mn2+-dependent RNase HII and Mg2+-dependent RNase HIII from Bacillus subtilis: classification of RNases H into three families.
Biochemistry 1999;38(2):605-18.
1999: Huy N Q; Jin S; Amada K; Haruki M; Huu N B; Hang D T; Ha D T; Imanaka T; Morikawa M; Kanaya S
Characterization of petroleum-degrading bacteria from oil-contaminated sites in Vietnam.
Journal of bioscience and bioengineering 1999;88(1):100-2.
1999: Ohtani N; Haruki M; Morikawa M; Kanaya S
Molecular diversities of RNases H.
Journal of bioscience and bioengineering 1999;88(1):12-9.
1999: Okibe N; Amada K; Hirano S; Haruki M; Imanaka T; Morikawa M; Kanaya S
Gene cloning and characterization of aldehyde dehydrogenase from a petroleum-degrading bacterium, strain HD-1.
Journal of bioscience and bioengineering 1999;88(1):7-11.
1998: Koga Y; Morikawa M; Haruki M; Nakamura H; Imanaka T; Kanaya S
Thermostable glycerol kinase from a hyperthermophilic archaeon: gene cloning and characterization of the recombinant enzyme.
Protein engineering 1998;11(12):1219-27.
1998: Haruki M; Hayashi K; Kochi T; Muroya A; Koga Y; Morikawa M; Imanaka T; Kanaya S
Gene cloning and characterization of recombinant RNase HII from a hyperthermophilic archaeon.
Journal of bacteriology 1998;180(23):6207-14.
1998: Hirano N; Haruki M; Morikawa M; Kanaya S
Stabilization of ribonuclease HI from Thermus thermophilus HB8 by the spontaneous formation of an intramolecular disulfide bond.
Biochemistry 1998;37(36):12640-8.
1998: Kanaya S; Koyanagi T; Kanaya E
An esterase from Escherichia coli with a sequence similarity to hormone-sensitive lipase.
The Biochemical journal 1998;332 ( Pt 1)():75-80.
1998: Yamasaki K; Akasako-Furukawa A; Kanaya S
Structural stability and internal motions of Escherichia coli ribonuclease HI: 15N relaxation and hydrogen-deuterium exchange analyses.
Journal of molecular biology 1998;277(3):707-22.
1997: Haruki M; Noguchi E; Kanaya S; Crouch R J
Kinetic and stoichiometric analysis for the binding of Escherichia coli ribonuclease HI to RNA-DNA hybrids using surface plasmon resonance.
The Journal of biological chemistry 1997;272(35):22015-22.
1997: Akasako A; Haruki M; Oobatake M; Kanaya S
Conformational stabilities of Escherichia coli RNase HI variants with a series of amino acid substitutions at a cavity within the hydrophobic core.
The Journal of biological chemistry 1997;272(30):18686-93.
1997: Rashid N; Morikawa M; Nagahisa K; Kanaya S; Imanaka T
Characterization of a RecA/RAD51 homologue from the hyperthermophilic archaeon Pyrococcus sp. KOD1.
Nucleic acids research 1997;25(4):719-26.
1996: Kanaya S; Oobatake M; Liu Y
Thermal stability of Escherichia coli ribonuclease HI and its active site mutants in the presence and absence of the Mg2+ ion. Proposal of a novel catalytic role for Glu48.
The Journal of biological chemistry 1996;271(51):32729-36.
1996: Kashiwagi T; Jeanteur D; Haruki M; Katayanagi K; Kanaya S; Morikawa K
Proposal for new catalytic roles for two invariant residues in Escherichia coli ribonuclease HI.
Protein engineering 1996;9(10):857-67.
1996: Fujiwara S; Lee S G; Haruki M; Kanaya S; Takagi M; Imanaka T
Unusual enzyme characteristics of aspartyl-tRNA synthetase from hyperthermophilic archaeon Pyrococcus sp. KOD1.
FEBS letters 1996;394(1):66-70.
1995: Yamasaki K; Ogasahara K; Yutani K; Oobatake M; Kanaya S
Folding pathway of Escherichia coli ribonuclease HI: a circular dichroism, fluorescence, and NMR study.
Biochemistry 1995;34(51):16552-62.
1995: Kanaya S; Uchida T
Revised sequence of ribonuclease U2 in the substrate-binding region.
Journal of biochemistry 1995;118(4):681-2.
1995: Kanaya E; Kanaya S
Reconstitution of Escherichia coli RNase HI from the N-fragment with high helicity and the C-fragment with a disordered structure.
The Journal of biological chemistry 1995;270(34):19853-60.
1995: Kanaya E; Kanaya S
Kinetic analysis of Escherichia coli ribonuclease HI using oligomeric DNA/RNA substrates suggests an alternative mechanism for the interaction between the enzyme and the substrate.
European journal of biochemistry / FEBS 1995;231(3):557-62.
1995: Akasako A; Haruki M; Oobatake M; Kanaya S
High resistance of Escherichia coli ribonuclease HI variant with quintuple thermostabilizing mutations to thermal denaturation, acid denaturation, and proteolytic degradation.
Biochemistry 1995;34(25):8115-22.
1995: Yamasaki K; Saito M; Oobatake M; Kanaya S
Characterization of the internal motions of Escherichia coli ribonuclease HI by a combination of 15N-NMR relaxation analysis and molecular dynamics simulation: examination of dynamic models.
Biochemistry 1995;34(20):6587-601.
1995: Kanaya S; Ikehara M
Functions and structures of ribonuclease H enzymes.
Sub-cellular biochemistry 1995;24():377-422.
1994: Kanaya E; Uchiyama Y; Ohtsuka E; Ueno Y; Ikehara M; Kanaya S
Kinetic analyses of DNA-linked ribonucleases H with different sizes of DNA.
FEBS letters 1994;354(2):227-31.
1994: Haruki M; Noguchi E; Akasako A; Oobatake M; Itaya M; Kanaya S
A novel strategy for stabilization of Escherichia coli ribonuclease HI involving a screen for an intragenic suppressor of carboxyl-terminal deletions.
The Journal of biological chemistry 1994;269(43):26904-11.
1994: Oda Y; Yamazaki T; Nagayama K; Kanaya S; Kuroda Y; Nakamura H
Individual ionization constants of all the carboxyl groups in ribonuclease HI from Escherichia coli determined by NMR.
Biochemistry 1994;33(17):5275-84.
1994: Haruki M; Noguchi E; Nakai C; Liu Y Y; Oobatake M; Itaya M; Kanaya S
Investigating the role of conserved residue Asp134 in Escherichia coli ribonuclease HI by site-directed random mutagenesis.
European journal of biochemistry / FEBS 1994;220(2):623-31.
1994: Nakai C; Konishi A; Komatsu Y; Inoue H; Ohtsuka E; Kanaya S
Sequence-specific cleavage of RNA by a hybrid ribonuclease H.
FEBS letters 1994;339(1-2):67-72.
1993: Katayanagi K; Ishikawa M; Okumura M; Ariyoshi M; Kanaya S; Kawano Y; Suzuki M; Tanaka I; Morikawa K
Crystal structures of ribonuclease HI active site mutants from Escherichia coli.
The Journal of biological chemistry 1993;268(29):22092-9.
1993: Ishikawa K; Nakamura H; Morikawa K; Kimura S; Kanaya S
Cooperative stabilization of Escherichia coli ribonuclease HI by insertion of Gly-80b and Gly-77-->Ala substitution.
Biochemistry 1993;32(28):7136-42.
1993: Ishikawa K; Nakamura H; Morikawa K; Kanaya S
Stabilization of Escherichia coli ribonuclease HI by cavity-filling mutations within a hydrophobic core.
Biochemistry 1993;32(24):6171-8.
1993: Ishikawa K; Okumura M; Katayanagi K; Kimura S; Kanaya S; Nakamura H; Morikawa K
Crystal structure of ribonuclease H from Thermus thermophilus HB8 refined at 2.8 A resolution.
Journal of molecular biology 1993;230(2):529-42.
1993: Kanaya S; Oobatake M; Nakamura H; Ikehara M
pH-dependent thermostabilization of Escherichia coli ribonuclease HI by histidine to alanine substitutions.
Journal of biotechnology 1993;28(1):117-36.
1993: Okumura M; Ishikawa K; Kanaya S; Itaya M; Morikawa K
Crystallization and preliminary crystallographic analysis of ribonuclease H from Thermus thermophilus HB8.
Proteins 1993;15(1):108-11.
1993: Ishikawa K; Kimura S; Kanaya S; Morikawa K; Nakamura H
Structural study of mutants of Escherichia coli ribonuclease HI with enhanced thermostability.
Protein engineering 1993;6(1):85-91.
1993: Oda Y; Yoshida M; Kanaya S
Role of histidine 124 in the catalytic function of ribonuclease HI from Escherichia coli.
The Journal of biological chemistry 1993;268(1):88-92.
1992: Kimura S; Kanaya S; Nakamura H
Thermostabilization of Escherichia coli ribonuclease HI by replacing left-handed helical Lys95 with Gly or Asn.
The Journal of biological chemistry 1992;267(31):22014-7.
1992: Kimura S; Nakamura H; Hashimoto T; Oobatake M; Kanaya S
Stabilization of Escherichia coli ribonuclease HI by strategic replacement of amino acid residues with those from the thermophilic counterpart.
The Journal of biological chemistry 1992;267(30):21535-42.
1992: Kimura S; Oda Y; Nakai T; Katayanagi K; Kitakuni E; Nakai C; Nakamura H; Ikehara M; Kanaya S
Effect of cavity-modulating mutations on the stability of Escherichia coli ribonuclease HI.
European journal of biochemistry / FEBS 1992;206(2):337-43.
1992: Kanaya S; Itaya M
Expression, purification, and characterization of a recombinant ribonuclease H from Thermus thermophilus HB8.
The Journal of biological chemistry 1992;267(14):10184-92.
1992: Kanaya S; Nakai C; Konishi A; Inoue H; Ohtsuka E; Ikehara M
A hybrid ribonuclease H. A novel RNA cleaving enzyme with sequence-specific recognition.
The Journal of biological chemistry 1992;267(12):8492-8.
1992: Oda Y; Nakamura H; Yamazaki T; Nagayama K; Yoshida M; Kanaya S; Ikehara M
1H NMR studies of deuterated ribonuclease HI selectively labeled with protonated amino acids.
Journal of biomolecular NMR 1992;2(2):137-47.
1992: Katayanagi K; Miyagawa M; Matsushima M; Ishikawa M; Kanaya S; Nakamura H; Ikehara M; Matsuzaki T; Morikawa K
Structural details of ribonuclease H from Escherichia coli as refined to an atomic resolution.
Journal of molecular biology 1992;223(4):1029-52.
1991: Nakamura H; Oda Y; Iwai S; Inoue H; Ohtsuka E; Kanaya S; Kimura S; Katsuda C; Katayanagi K; Morikawa K
How does RNase H recognize a DNA.RNA hybrid?
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11535-9.
1991: Oda Y; Nakamura H; Kanaya S; Ikehara M
Binding of metal ions to E. coli RNase HI observed by 1H-15N heteronuclear 2D NMR.
Journal of biomolecular NMR 1991;1(3):247-55.
1991: Kanaya S; Katsuda-Nakai C; Ikehara M
Importance of the positive charge cluster in Escherichia coli ribonuclease HI for the effective binding of the substrate.
The Journal of biological chemistry 1991;266(18):11621-7.
1991: Kanaya S; Katayanagi K; Morikawa K; Inoue H; Ohtsuka E; Ikehara M
Effect of mutagenesis at each of five histidine residues on enzymatic activity and stability of ribonuclease H from Escherichia coli.
European journal of biochemistry / FEBS 1991;198(2):437-40.
1991: Kanaya S; Katsuda C; Kimura S; Nakai T; Kitakuni E; Nakamura H; Katayanagi K; Morikawa K; Ikehara M
Stabilization of Escherichia coli ribonuclease H by introduction of an artificial disulfide bond.
The Journal of biological chemistry 1991;266(10):6038-44.
1990: Kanaya E; Kanaya S; Kikuchi M
Introduction of a non-native disulfide bridge to human lysozyme by cysteine scanning mutagenesis.
Biochemical and biophysical research communications 1990;173(3):1194-9.
1990: Kanaya S; Kimura S; Katsuda C; Ikehara M
Role of cysteine residues in ribonuclease H from Escherichia coli. Site-directed mutagenesis and chemical modification.
The Biochemical journal 1990;271(1):59-66.
1990: Katayanagi K; Miyagawa M; Matsushima M; Ishikawa M; Kanaya S; Ikehara M; Matsuzaki T; Morikawa K
Three-dimensional structure of ribonuclease H from E. coli.
Nature 1990;347(6290):306-9.
1990: Kikuchi M; Taniyama Y; Kanaya S; Takao T; Shimonishi Y
Occurrence of S-(1,2-dicarboxyethyl)-cysteine at position 77 in mutant human lysozyme secreted by Saccharomyces cerevisiae.
European journal of biochemistry / FEBS 1990;187(2):315-20.
1989: Kanaya S; Kohara A; Miyagawa M; Matsuzaki T; Morikawa K; Ikehara M
Overproduction and preliminary crystallographic study of ribonuclease H from Escherichia coli.
The Journal of biological chemistry 1989;264(20):11546-9.

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