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Brian Bacskai

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Hong Xie; Steven Hou; Jun Jiang; Jonathan Kelly; Maria Sekutowicz; Brian J Bacskai
Rapid cell death is preceded by amyloid plaque-mediated oxidative stress.
Juan Jose Ramos-Rodriguez; Tara L Spires-Jones; Diana Thyssen; Brian J Bacskai; Esther Berrocoso; Maria Isabel Murillo-Carretero; Mar Pacheco-Herrero; Monica Garcia-Alloza
Rapid β-amyloid deposition and cognitive impairment after cholinergic denervation in APP/PS1 mice.
Julia L Gregory; Claudia M Prada; Monica Garcia-Alloza; Steven M Greenberg; Michal Arbel-Ornath; Brian J Bacskai; Rebecca A Betensky; Sara J Fine; Matthew P Frosch
Reducing available soluble β-amyloid prevents progression of cerebral amyloid angiopathy in transgenic mice.

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All Publications

2013: Hong Xie; Steven Hou; Jun Jiang; Jonathan Kelly; Maria Sekutowicz; Brian J Bacskai
Rapid cell death is preceded by amyloid plaque-mediated oxidative stress.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(19):7904-9.
2013: Juan Jose Ramos-Rodriguez; Tara L Spires-Jones; Diana Thyssen; Brian J Bacskai; Esther Berrocoso; Maria Isabel Murillo-Carretero; Mar Pacheco-Herrero; Monica Garcia-Alloza
Rapid β-amyloid deposition and cognitive impairment after cholinergic denervation in APP/PS1 mice.
Journal of neuropathology and experimental neurology 2013;72(4):272-85.
2012: Julia L Gregory; Claudia M Prada; Monica Garcia-Alloza; Steven M Greenberg; Michal Arbel-Ornath; Brian J Bacskai; Rebecca A Betensky; Sara J Fine; Matthew P Frosch
Reducing available soluble β-amyloid prevents progression of cerebral amyloid angiopathy in transgenic mice.
Journal of neuropathology and experimental neurology 2012;71(11):1009-17.
2012: Tadafumi Hashimoto; David M Holtzman; Yukiko Hori; Kenneth W Adams; Brian J Bacskai; Adrian Olaf Banerji; Mary Beth Finn; Matthew P Frosch; Daniel Joyner; Akinori Mitani; Alberto Serrano-Pozo; Tara L Spires-Jones; Shuko Takeda; Diana H Thyssen; Bradley T Hyman
Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(43):15181-92.
2012: Alberto Serrano-Pozo; Matthew L Mielke; Alona Muzitansky; Brian J Bacskai; Rebecca A Betensky; Matthew P Frosch; Teresa Gómez-Isla; John H Growdon; Bradley T Hyman
Stable size distribution of amyloid plaques over the course of Alzheimer disease.
Journal of neuropathology and experimental neurology 2012;71(8):694-701.
2012: Hai-Yan Wu; Kengo Uemura; Brian J Bacskai; Oksana Berezovska; Zhan-Yun Fan; Cynthia L Grosskreutz; Tadafumi Hashimoto; Eloise Hudry; Bradley T Hyman
Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(15):5298-309.
2012: Eloise Hudry; Roland Matsouaka; Tara L Spires-Jones; Hai-Yan Wu; Michal Arbel-Ornath; Brian J Bacskai; Rebecca A Betensky; Zhanyun Fan; Tadafumi Hashimoto; Bradley T Hyman
Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(9):3176-92.
2012: Rob J A Nabuurs; Maarten Rotman; Kim S Rutgers; Mark A Van Buchem; Silvère M van der Maarel; Brian J Bacskai; Maaike E de Backer; Athanasios Metaxas; Mick Welling; Louise van der Weerd
In vivo detection of amyloid-β deposits using heavy chain antibody fragments in a transgenic mouse model for Alzheimer's disease.
PloS one 2012;7(6):e38284.
2012: Jeong Hyun Lee; Brian J Bacskai; Cenk Ayata
Genetic animal models of cerebral vasculopathies.
Progress in molecular biology and translational science 2012;105():25-55.
2011: Kim S Rutgers; Mark A Van Buchem; Sjoerd G van Duinen; Alexandra Van Remoortere; C Theo Verrips; Brian J Bacskai; Matthew P Frosch; Steven M Greenberg; Marion L C Maat-Schieman; Silvère M van der Maarel
Differential recognition of vascular and parenchymal beta amyloid deposition.
Neurobiology of aging 2011;32(10):1774-83.
2011: Tara L Spires-Jones; Alix de Calignon; Melanie Meyer-Luehmann; Brian J Bacskai; Bradley T Hyman
Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging.
Methods (San Diego, Calif.) 2011;53(3):201-7.
2011: Phillip B Jones; Kenneth W Adams; Anete Rozkalne; Tara L Spires-Jones; Tammy T Hshieh; Tadafumi Hashimoto; Christine A F von Armin; Mathew Mielke; Brian J Bacskai; Bradley T Hyman
Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain.
PloS one 2011;6(1):e14586.
2010: Monica Garcia-Alloza; Laura A Borrelli; Bradley T Hyman; Brian J Bacskai
Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice.
Neurobiology of aging 2010;31(12):2058-68.
2010: Volodymyr I Dzhala; Kishore V Kuchibhotla; Joseph C Glykys; Kristopher T Kahle; Waldemar B Swiercz; Guoping Feng; Thomas Kuner; George J Augustine; Brian J Bacskai; Kevin J Staley
Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(35):11745-61.
2010: Scott B Raymond; David A Boas; Brian J Bacskai; Anand T N Kumar
Lifetime-based tomographic multiplexing.
Journal of biomedical optics 2010;15(4):046011.
2010: M Coma; L Serenó; B Da Rocha-Souto; T C Scotton; J España; M B Sánchez; M Rodríguez; J Agulló; C Guardia-Laguarta; Monica Garcia-Alloza; L A Borrelli; Jordi Clarimón; Alberto Lleó; Brian J Bacskai; C A Saura; Bradley T Hyman; Teresa Gómez-Isla
Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease.
Neurobiology of disease 2010;38(3):482-91.
2010: Alix de Calignon; Leora M Fox; Rose Pitstick; George A Carlson; Brian J Bacskai; Tara L Spires-Jones; Bradley T Hyman
Caspase activation precedes and leads to tangles.
Nature 2010;464(7292):1201-4.
2010: Hai-Yan Wu; Eloise Hudry; Tadafumi Hashimoto; Kishore Kuchibhotla; Anete Rozkalne; Zhanyun Fan; Tara Spires-Jones; Hong Xie; Michal Arbel-Ornath; Cynthia L Grosskreutz; Brian J Bacskai; Bradley T Hyman
Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(7):2636-49.
2009: Chongzhao Ran; Xiaoyin Xu; Scott B Raymond; Brian J Ferrara; Krista Neal; Brian J Bacskai; Zdravka Medarova; Anna Moore
Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits.
Journal of the American Chemical Society 2009;131(42):15257-61.
2009: S B Raymond; A T N Kumar; David A Boas; Brian J Bacskai
Optimal parameters for near infrared fluorescence imaging of amyloid plaques in Alzheimer's disease mouse models.
Physics in medicine and biology 2009;54(20):6201-16.
2009: Melanie Meyer-Luehmann; Matthew Mielke; Tara L Spires-Jones; Will Stoothoff; Phill Jones; Brian J Bacskai; Bradley T Hyman
A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(40):12636-40.
2009: Will Stoothoff; Phillip B Jones; Tara L Spires-Jones; Daniel Joyner; Ekta Chhabra; Kathryn Bercury; Zhanyun Fan; Hong Xie; Brian J Bacskai; Jon Edd; daniel irimia; Bradley T Hyman
Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport.
Journal of neurochemistry 2009;111(2):417-27.
2009: Joseph Glykys; Volodymyr I Dzhala; Kishore V Kuchibhotla; Guoping Feng; Thomas Kuner; George Augustine; Brian J Bacskai; Kevin J Staley
Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures.
Neuron 2009;63(5):657-72.
2009: Anand T N Kumar; Euiheon Chung; Scott B Raymond; Jeroen A J M van de Water; Khalid Shah; Dai Fukumura; Rakesh K Jain; Brian J Bacskai; David A Boas
Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast.
Optics letters 2009;34(13):2066-8.
2009: Monica Garcia-Alloza; Claudia Prada; Carli Lattarulo; Sara Fine; Laura A Borrelli; Rebecca A Betensky; Steven M Greenberg; Matthew P Frosch; Brian J Bacskai
Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice.
Journal of neurochemistry 2009;109(6):1636-47.
2009: Kishore V Kuchibhotla; Carli R Lattarulo; Bradley T Hyman; Brian J Bacskai
Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice.
Science (New York, N.Y.) 2009;323(5918):1211-5.
2009: Tara L Spires-Jones; Matthew L Mielke; Anete Rozkalne; Melanie Meyer-Luehmann; Alix de Calignon; Brian J Bacskai; Dale Schenk; Bradley T Hyman
Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease.
Neurobiology of disease 2009;33(2):213-20.
2009: Yongfeng Jiang; Laura Borrelli; Brian J Bacskai; Yoshihide Kanaoka; Joshua A Boyce
P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(2):1129-37.
2009: Kengo Uemura; Christina M Lill; Xuejing Li; Jessica A Peters; Alexander Ivanov; Zhanyun Fan; Bart DeStrooper; Brian J Bacskai; Bradley T Hyman; Oksana Berezovska
Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.
PloS one 2009;4(11):e7893.
2009: Monica Garcia-Alloza; Meenakshi Subramanian; Diana Thyssen; Laura A Borrelli; Abdul Fauq; Pritam Das; todd golde; Bradley T Hyman; Brian J Bacskai
Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575.
Molecular neurodegeneration 2009;4():19.
2008: Jessica Koenigsknecht-Talboo; Melanie Meyer-Luehmann; Maia Parsadanian; Monica Garcia-Alloza; Mary Beth Finn; Bradley T Hyman; Brian J Bacskai; David M Holtzman
Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(52):14156-64.
2008: Asim K Mandal; Phillip B Jones; Angela M Bair; Peter Christmas; Douglas Miller; Ting-ting D Yamin; Douglas Wisniewski; John Menke; Jilly F Evans; Bradley T Hyman; Brian J Bacskai; Mei Chen; David M Lee; Boris Nikolic; Roy J Soberman
The nuclear membrane organization of leukotriene synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(51):20434-9.
2008: William H Stoothoff; Brian J Bacskai; Bradley T Hyman
Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons.
Journal of biomedical optics 2008;13(6):064039.
2008: Anand T N Kumar; Scott B Raymond; Andrew K Dunn; Brian J Bacskai; David A Boas
A time domain fluorescence tomography system for small animal imaging.
IEEE transactions on medical imaging 2008;27(8):1152-63.
2008: Kishore V Kuchibhotla; Samuel T Goldman; Carli R Lattarulo; Hai-Yan Wu; Bradley T Hyman; Brian J Bacskai
Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks.
Neuron 2008;59(2):214-25.
2008: Anand T N Kumar; Scott B Raymond; Brian J Bacskai; David A Boas
Comparison of frequency-domain and time-domain fluorescence lifetime tomography.
Optics letters 2008;33(5):470-2.
2008: Scott B Raymond; Jesse Skoch; Ivory D Hills; Evgueni E Nesterov; Timothy M Swager; Brian J Bacskai
Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology.
European journal of nuclear medicine and molecular imaging 2008;35 Suppl 1():S93-8.
2008: Melanie Meyer-Luehmann; Tara L Spires-Jones; Claudia Prada; Monica Garcia-Alloza; Alix de Calignon; Anete Rozkalne; Jessica Koenigsknecht-Talboo; David M Holtzman; Brian J Bacskai; Bradley T Hyman
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.
Nature 2008;451(7179):720-4.
2008: Tara L Spires-Jones; Alix de Calignon; Toshifumi Matsui; Cindy Zehr; Rose Pitstick; Hai-Yan Wu; Jennifer D Osetek; Phillip B Jones; Brian J Bacskai; Mel B Feany; George A Carlson; Karen K. Hsiao Ashe; Jada Lewis; Bradley T Hyman
In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(4):862-7.
2008: Scott B Raymond; Lisa H Treat; Jonathan D Dewey; Nathan J McDannold; Kullervo Hynynen; Brian J Bacskai
Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models.
PloS one 2008;3(5):e2175.
2008: Phillip B Jones; Aneta Rozkalne; Melanie Meyer-Luehmann; Tara L Spires-Jones; Alexandra Makarova; Anand T N Kumar; Oksana Berezovska; Brian J Bacskai; Bradley T Hyman
Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy.
Journal of biomedical optics 2008;13(1):014008.
2007: Monica Garcia-Alloza; Brian J Ferrara; Sarah A Dodwell; Gregory A Hickey; Bradley T Hyman; Brian J Bacskai
A limited role for microglia in antibody mediated plaque clearance in APP mice.
Neurobiology of disease 2007;28(3):286-92.
2007: Yongfeng Jiang; Laura A Borrelli; Yoshihide Kanaoka; Brian J Bacskai; Joshua A Boyce
CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells.
Blood 2007;110(9):3263-70.
2007: Tara L Spires-Jones; Melanie Meyer-Luehmann; Jennifer D Osetek; Phillip B Jones; Edward A Stern; Brian J Bacskai; Bradley T Hyman
Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model.
The American journal of pathology 2007;171(4):1304-11.
2007: Hwa Kyoung Shin; Phillip B Jones; Monica Garcia-Alloza; Laura Borrelli; Steven M Greenberg; Brian J Bacskai; Matthew P Frosch; Bradley T Hyman; Michael A Moskowitz; Cenk Ayata
Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy.
Brain : a journal of neurology 2007;130(Pt 9):2310-9.
2007: Monica Garcia-Alloza; L A Borrelli; A Rozkalne; Bradley T Hyman; Brian J Bacskai
Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model.
Journal of neurochemistry 2007;102(4):1095-104.
2007: Brian J Bacskai; Matthew P Frosch; Stefanie H Freeman; Scott B Raymond; Jean C Augustinack; Keith A Johnson; Michael C Irizarry; William E Klunk; Chester A Mathis; Steven T DeKosky; Steven M Greenberg; Bradley T Hyman; John H Growdon
Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report.
Archives of neurology 2007;64(3):431-4.
2007: Elizabeth M C Hillman; Anna Devor; Matthew B Bouchard; Andrew K Dunn; G W Krauss; Jesse Skoch; Brian J Bacskai; Anders Dale; David A Boas
Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation.
NeuroImage 2007;35(1):89-104.
2007: Claudia M Prada; Monica Garcia-Alloza; Rebecca A Betensky; Sandy X Zhang-Nunes; Steven M Greenberg; Brian J Bacskai; Matthew P Frosch
Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(8):1973-80.
2007: Scott B Raymond; Jesse Skoch; Brian J Bacskai; Kullervo Hynynen
Modular design for in vivo optical imaging and ultrasound treatment in the murine brain.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 2007;54(2):431-4.
2007: Scott B Raymond; Jesse Skoch; Kullervo Hynynen; Brian J Bacskai
Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(2):393-403.
2006: Anand T Kumar; Scott B Raymond; Gregory Boverman; David A Boas; Brian J Bacskai
Time resolved fluorescence tomography of turbid media based on lifetime contrast.
Optics express 2006;14(25):12255-70.
2006: Monica Garcia-Alloza; Elissa M Robbins; Sandy X Zhang-Nunes; Susan M Purcell; Rebecca A Betensky; Susan Raju; Claudia Prada; Steven M Greenberg; Brian J Bacskai; Matthew P Frosch
Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease.
Neurobiology of disease 2006;24(3):516-24.
2006: Monica Garcia-Alloza; Sarah A Dodwell; Melanie Meyer-Luehmann; Bradley T Hyman; Brian J Bacskai
Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model.
Journal of neuropathology and experimental neurology 2006;65(11):1082-9.
2006: Shuzhen Guo; Sophia Wang; Woo Jean Kim; Seong-Ryong Lee; Matthew P Frosch; Brian J Bacskai; Steven M Greenberg; Eng H Lo
Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes.
Brain research 2006;1111(1):222-6.
2006: Sanja Sever; Jesse Skoch; Sherri L Newmyer; Rajesh Ramachandran; David Ko; Mary McKee; Richard Bouley; Dennis A Ausiello; Bradley T Hyman; Brian J Bacskai
Physical and functional connection between auxilin and dynamin during endocytosis.
The EMBO journal 2006;25(18):4163-74.
2006: Phill B Jones; Lauren Herl; Oksana Berezovska; Anand T N Kumar; Brian J Bacskai; Bradley T Hyman
Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays.
Journal of biomedical optics 2006;11(5):054024.
2006: Elissa M Robbins; Rebecca A Betensky; Sarah B Domnitz; Susan M Purcell; Monica Garcia-Alloza; Charles Greenberg; G. William Rebeck; Bradley T Hyman; Steven M Greenberg; Matthew P Frosch; Brian J Bacskai
Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(2):365-71.
2006: Jesse Skoch; Bradley T Hyman; Brian J Bacskai
Preclinical characterization of amyloid imaging probes with multiphoton microscopy.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):401-7.
2005: Anand T N Kumar; Jesse Skoch; Brian J Bacskai; David A Boas; Andrew K Dunn
Fluorescence-lifetime-based tomography for turbid media.
Optics letters 2005;30(24):3347-9.
2005: Zhongmin Xiang; Evgueni E Nesterov; Jesse Skoch; Tong Lin; Bradley T Hyman; Timothy M Swager; Brian J Bacskai; Steven A Reeves
Detection of myelination using a novel histological probe.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(12):1511-6.
2005: Evgueni E Nesterov; Jesse Skoch; Bradley T Hyman; William E Klunk; Brian J Bacskai; Timothy M Swager
In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers.
Angewandte Chemie (International ed. in English) 2005;44(34):5452-6.
2005: Tara L Spires; Melanie Meyer-Luehmann; Edward A Stern; Pamela J McLean; Jesse Skoch; Paul T Nguyen; Brian J Bacskai; Bradley T Hyman
Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(31):7278-87.
2005: Sarah B Domnitz; Elissa M Robbins; Alex W Hoang; Monica Garcia-Alloza; Bradley T Hyman; G. William Rebeck; Steven M Greenberg; Brian J Bacskai; Matthew P Frosch
Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease.
Journal of neuropathology and experimental neurology 2005;64(7):588-94.
2005: Christine A F Von Arnim; Ayae Kinoshita; Ithan D Peltan; Michelle M Tangredi; Lauren Herl; Bonny M Lee; Robert Spoelgen; Tammy T Hshieh; Sripriya Ranganathan; Frances D Battey; Chun-Xiang Liu; Brian J Bacskai; Sanja Sever; Michael C Irizarry; Dudley K Strickland; Bradley T Hyman
The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.
The Journal of biological chemistry 2005;280(18):17777-85.
2005: todd golde; Brian J Bacskai
Bringing amyloid into focus.
Nature biotechnology 2005;23(5):552-4.
2005: Oksana Berezovska; Alberto Lleo; Lauren Herl; Matthew P Frosch; Edward A Stern; Brian J Bacskai; Bradley T Hyman
Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(11):3009-17.
2005: Robert P Brendza; Brian J Bacskai; John R Cirrito; Kelly Simmons; Jesse Skoch; William E Klunk; Chester A Mathis; Kelly R Bales; Steven M Paul; Bradley T Hyman; David M Holtzman
Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice.
The Journal of clinical investigation 2005;115(2):428-33.
2005: Sanja Sever; Jesse Skoch; Brian J Bacskai; Sherri L Newmyer
Assays and functional properties of auxilin-dynamin interactions.
Methods in enzymology 2005;404():570-85.
2005: Jesse Skoch; Gregory A Hickey; Stephen T Kajdasz; Bradley T Hyman; Brian J Bacskai
In vivo imaging of amyloid-beta deposits in mouse brain with multiphoton microscopy.
Methods in molecular biology (Clifton, N.J.) 2005;299():349-63.
2005: Jesse Skoch; Andrew Dunn; Bradley T Hyman; Brian J Bacskai
Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology.
Journal of biomedical optics 2005;10(1):11007.
2004: Alberto Lleó; Oksana Berezovska; Lauren Herl; Susan Raju; Amy Deng; Brian J Bacskai; Matthew P Frosch; Michael C Irizarry; Bradley T Hyman
Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.
Nature medicine 2004;10(10):1065-6.
2004: Piera Pasinelli; Mary Elizabeth Belford; Niall Lennon; Brian J Bacskai; Bradley T Hyman; Davide Trotti; Robert H Brown
Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria.
Neuron 2004;43(1):19-30.
2004: Edward A Stern; Brian J Bacskai; Gregory A Hickey; Frank J Attenello; Julianne A Lombardo; Bradley T Hyman
Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(19):4535-40.
2004: Asim K Mandal; Jesse Skoch; Brian J Bacskai; Bradley T Hyman; Peter Christmas; Douglas Miller; Ting-ting D Yamin; Shihua Xu; Douglas Wisniewski; Jilly F Evans; Roy J Soberman
The membrane organization of leukotriene synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6587-92.
2004: Monica Garcia-Alloza; Brian J Bacskai
Techniques for brain imaging in vivo.
Neuromolecular medicine 2004;6(1):65-78.
2003: Niall Lennon; Alvin Kho; Brian J Bacskai; Sarah L Perlmutter; Bradley T Hyman; Robert H Brown
Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing.
The Journal of biological chemistry 2003;278(50):50466-73.
2003: Julianne A Lombardo; Edward A Stern; Megan E McLellan; Stephen T Kajdasz; Gregory A Hickey; Brian J Bacskai; Bradley T Hyman
Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(34):10879-83.
2003: William E Klunk; Henry Willy Engler; agneta nordberg; Brian J Bacskai; Yanming Wang; Julie C Price; Mats Bergström; Bradley T Hyman; Bengt Långström; Chester A Mathis
Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography.
Neuroimaging clinics of North America 2003;13(4):781-9, ix.
2003: Pavan Ramdya; Jesse Skoch; Brian J Bacskai; Bradley T Hyman; Oksana Berezovska
Activated Notch1 associates with a presenilin-1/gamma-secretase docking site.
Journal of neurochemistry 2003;87(4):843-50.
2003: Brian J Bacskai; Gregory A Hickey; Jesse Skoch; Stephen T Kajdasz; Yanming Wang; Guo-Feng Huang; Chester A Mathis; William E Klunk; Bradley T Hyman
Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12462-7.
2003: Brian J Bacskai; Jesse Skoch; Gregory A Hickey; Racquel Allen; Bradley T Hyman
Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques.
Journal of biomedical optics 2003;8(3):368-75.
2003: Oksana Berezovska; Brian J Bacskai; Bradley T Hyman
Monitoring proteins in intact cells.
Science of aging knowledge environment : SAGE KE 2003;2003(23):PE14.
2003: Oksana Berezovska; Pavan Ramdya; Jesse Skoch; Michael S Wolfe; Brian J Bacskai; Bradley T Hyman
Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(11):4560-6.
2003: Steven M Greenberg; Brian J Bacskai; Bradley T Hyman
Alzheimer disease's double-edged vaccine.
Nature medicine 2003;9(4):389-90.
2003: Megan E McLellan; Stephen T Kajdasz; Bradley T Hyman; Brian J Bacskai
In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(6):2212-7.
2003: J D D'Amore; Stephen T Kajdasz; Megan E McLellan; Brian J Bacskai; Edward A Stern; Bradley T Hyman
In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories.
Journal of neuropathology and experimental neurology 2003;62(2):137-45.
2002: Brian J Bacskai; Bradley T Hyman
Alzheimer's disease: what multiphoton microscopy teaches us.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2002;8(5):386-90.
2002: Brian J Bacskai; Stephen T Kajdasz; Megan E McLellan; Dora Games; Peter Seubert; Dale Schenk; Bradley T Hyman
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(18):7873-8.
2002: William E Klunk; Brian J Bacskai; Chester A Mathis; Stephen T Kajdasz; Megan E McLellan; Matthew P Frosch; Manik L Debnath; Daniel P Holt; Yanming Wang; Bradley T Hyman
Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.
Journal of neuropathology and experimental neurology 2002;61(9):797-805.
2002: Brian J Bacskai; William E Klunk; Chester A Mathis; Bradley T Hyman
Imaging amyloid-beta deposits in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(9):1035-41.
2002: Linda Kotilinek; Brian J Bacskai; Marcus A Westerman; Takeshi Kawarabayashi; Linda Younkin; Bradley T Hyman; Steven G Younkin; Karen K. Hsiao Ashe
Reversible memory loss in a mouse transgenic model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(15):6331-5.
2002: Chester A Mathis; Brian J Bacskai; Stephen T Kajdasz; Megan E McLellan; Matthew P Frosch; Bradley T Hyman; Daniel P Holt; Yanming Wang; Guo-Feng Huang; Manik L Debnath; William E Klunk
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.
Bioorganic & medicinal chemistry letters 2002;12(3):295-8.
2001: Richard Christie; E Kimchi; Stephen T Kajdasz; Brian J Bacskai; Bradley T Hyman
Multiphoton microscopy and amyloid angiopathy.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2001;8 Suppl 1():48-50.
2001: E Y Kimchi; Stephen T Kajdasz; Brian J Bacskai; Bradley T Hyman
Analysis of cerebral amyloid angiopathy in a transgenic mouse model of Alzheimer disease using in vivo multiphoton microscopy.
Journal of neuropathology and experimental neurology 2001;60(3):274-9.
2001: Brian J Bacskai; Stephen T Kajdasz; Richard Christie; C Carter; Dora Games; Peter Seubert; Dale Schenk; Bradley T Hyman
Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.
Nature medicine 2001;7(3):369-72.
2001: Richard Christie; Brian J Bacskai; Warren R Zipfel; R M Williams; Stephen T Kajdasz; Watt W Webb; Bradley T Hyman
Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(3):858-64.
2000: Brian J Bacskai; MengQi Xia; Dudley K Strickland; G. William Rebeck; Bradley T Hyman
The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11551-6.
2000: MengQi Xia; Brian J Bacskai; R B Knowles; S X Qin; Bradley T Hyman
Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease.
Journal of neuroimmunology 2000;108(1-2):227-35.
1998: ER Grant; Brian J Bacskai; N J Anegawa; David Pleasure; David R Lynch
Opposing contributions of NR1 and NR2 to protein kinase C modulation of NMDA receptors.
Journal of neurochemistry 1998;71(4):1471-81.
1997: ER Grant; Brian J Bacskai; David Pleasure; D B Pritchett; MJ Gallagher; S J Kendrick; L J Kricka; David R Lynch
N-methyl-D-aspartate receptors expressed in a nonneuronal cell line mediate subunit-specific increases in free intracellular calcium.
The Journal of biological chemistry 1997;272(1):647-56.
1996: A Yoshioka; Brian J Bacskai; David Pleasure
Pathophysiology of oligodendroglial excitotoxicity.
Journal of neuroscience research 1996;46(4):427-37.
1995: Brian J Bacskai; P Wallén; Varda Lev-Ram; S Grillner; Roger Y Tsien
Activity-related calcium dynamics in lamprey motoneurons as revealed by video-rate confocal microscopy.
Neuron 1995;14(1):19-28.
1994: Rama Ranganathan; Brian J Bacskai; Roger Y Tsien; Charles S Zuker
Cytosolic calcium transients: spatial localization and role in Drosophila photoreceptor cell function.
Neuron 1994;13(4):837-48.
1994: Roberto Civitelli; Brian J Bacskai; M P Mahaut-Smith; S R Adams; Louis V Avioli; Roger Y Tsien
Single-cell analysis of cyclic AMP response to parathyroid hormone in osteoblastic cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(9):1407-17.
1993: Roger Y Tsien; Brian J Bacskai; S R Adams
FRET for studying intracellular signalling.
Trends in cell biology 1993;3(7):242-5.
1993: Brian J Bacskai; B Hochner; M Mahaut-Smith; S R Adams; B K Kaang; Eric R Kandel; Roger Y Tsien
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons.
Science (New York, N.Y.) 1993;260(5105):222-6.
1993: S Adams; Brian J Bacskai; A T Harootunian; M Mahaut-Smith; P J Sammak; Susan S Taylor; Roger Y Tsien
Imaging of cAMP signals and A-kinase translocation in single living cells.
Advances in second messenger and phosphoprotein research 1993;28():167-70.
1993: S R Adams; Brian J Bacskai; B Hochner; B K Kaang; Eric R Kandel; M Mahaut-Smith; Roger Y Tsien
Confocal imaging of cAMP signals in Aplysia neurons.
The Japanese journal of physiology 1993;43 Suppl 1():S91-3.
1991: John Pizzonia; Frank A Gesek; S M Kennedy; Bonita Coutermarsh; Brian J Bacskai; Peter A Friedman
Immunomagnetic separation, primary culture, and characterization of cortical thick ascending limb plus distal convoluted tubule cells from mouse kidney.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1991;27A(5):409-16.
1990: Brian J Bacskai; Peter A Friedman
Activation of latent Ca2+ channels in renal epithelial cells by parathyroid hormone.
Nature 1990;347(6291):388-91.