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Hideo Kaneko

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Takashi Mori; Mika Ota; Koichi Saito; Yoshiharu Tanimoto; Naohiko Isobe; Sachiko Kitamoto; Takaomi Masakado; Hideo Kaneko
Comparison of cytokine profiles in bronchoalveolar lavage fluid of mice exposed to respiratory and contact sensitizers.
Kazuki Mikata; Naohiko Isobe; Hideo Kaneko
Biotransformation and enzymatic reactions of synthetic pyrethroids in mammals.
Kiyoshi Higashi; Hideki Kubo; Toshiyuki Mikami; Hiroyuki Watanabe; Ko Fujimori; Hideo Kaneko
Adipokine ganglioside GM2 activator protein stimulates insulin secretion.

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2012: Takashi Mori; Mika Ota; Koichi Saito; Yoshiharu Tanimoto; Naohiko Isobe; Sachiko Kitamoto; Takaomi Masakado; Hideo Kaneko
Comparison of cytokine profiles in bronchoalveolar lavage fluid of mice exposed to respiratory and contact sensitizers.
The Journal of toxicological sciences 2012;37(2):337-43.
2012: Kazuki Mikata; Naohiko Isobe; Hideo Kaneko
Biotransformation and enzymatic reactions of synthetic pyrethroids in mammals.
Topics in current chemistry 2012;314():113-35.
2011: Kiyoshi Higashi; Hideki Kubo; Toshiyuki Mikami; Hiroyuki Watanabe; Ko Fujimori; Hideo Kaneko
Adipokine ganglioside GM2 activator protein stimulates insulin secretion.
FEBS letters 2011;585(16):2587-91.
2011: Tomoyuki Takaku; Kazuki Mikata; Masayoshi Matsui; Kazuhiko Nishioka; Naohiko Isobe; Hideo Kaneko
In vitro metabolism of trans-permethrin and its major metabolites, PBalc and PBacid, in humans.
Journal of agricultural and food chemistry 2011;59(9):5001-5.
2011: Hideo Kaneko
Pyrethroids: mammalian metabolism and toxicity.
Journal of agricultural and food chemistry 2011;59(7):2786-91.
2010: Kiyoshi Higashi; Toshiyuki Mikami; Toru Yamada; Hitoshi Kawashima; Toru Kimura; Hideo Kaneko
A novel adipokine GM2AP impairs insulin signaling.
Biochemical and biophysical research communications 2010;402(3):571-6.
2010: H Nagahori; Haruyuki Matsunaga; Yoshitaka Tomigahara; Naohiko Isobe; Hideo Kaneko
Metabolism of 2,6-dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl ether (pyridalyl) in rats after repeated oral administration and a simple physiologically based pharmacokinetic modeling in brown and white adipose tissues.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(5):824-32.
2009: H Nagahori; Koichi Saito; Yoshitaka Tomigahara; Naohiko Isobe; Hideo Kaneko
Metabolism of pyridalyl in rats.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(12):2284-9.
2009: H Nagahori; Yoshitaka Tomigahara; Naohiko Isobe; Hideo Kaneko
Metabolism of pyridalyl in rats: excretion, distribution, and biotransformation of dichloropropenyl-labeled pyridalyl.
Journal of agricultural and food chemistry 2009;57(22):10845-51.
2009: Hirokazu Tarui; Jun Abe; Yoshitaka Tomigahara; Satoshi Kawamura; Hideo Kaneko
Metabolism of procymidone derivatives in female rats.
Journal of agricultural and food chemistry 2009;57(22):10883-8.
2009: H Nagahori; Haruyuki Matsunaga; Yoshitaka Tomigahara; Naohiko Isobe; Hideo Kaneko
Metabolism of flufenpyr-ethyl in rats and mice.
Journal of agricultural and food chemistry 2009;57(11):4872-7.
2009: Kazumasa Akita; Yasuhiko Takahashi; Masaki Kataoka; Koichi Saito; Hideo Kaneko
Subcellular localization of a novel G protein XLGalpha(olf).
Biochemical and biophysical research communications 2009;381(4):582-6.
2009: Norihisa Ooe; Koichi Saito; Hideo Kaneko
Characterization of functional heterodimer partners in brain for a bHLH-PAS factor NXF.
Biochimica et biophysica acta 2009;1789(3):192-7.
2009: Tomoya Yamada; Satoshi Uwagawa; Yasuyoshi Okuno; Samuel M Cohen; Hideo Kaneko
Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action.
Toxicological sciences : an official journal of the Society of Toxicology 2009;108(1):59-68.
2009: Norihisa Ooe; Kentaro Kobayashi; Kozo Motonaga; Koichi Saito; Hideo Kaneko
Dynamic regulation of bHLH-PAS-type transcription factor NXF gene expression and neurotrophin dependent induction of the transcriptional control activity.
Biochemical and biophysical research communications 2009;378(4):761-5.
2009: Norihisa Ooe; Kozo Motonaga; Kentaro Kobayashi; Koichi Saito; Hideo Kaneko
Functional characterization of basic helix-loop-helix-PAS type transcription factor NXF in vivo: putative involvement in an "on demand" neuroprotection system.
The Journal of biological chemistry 2009;284(2):1057-63.
2007: Norihisa Ooe; Koichi Saito; Kenji Oeda; Iwao Nakatuka; Hideo Kaneko
Characterization of Drosophila and Caenorhabditis elegans NXF-like-factors, putative homologs of mammalian NXF.
Gene 2007;400(1-2):122-30.
2006: Yoshitaka Tomigahara; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka
Metabolism of N-[(R)-1-(2,4-dichlorophenyl)ethyl]-2-cyano-3,3-dimethylbutanamide (Delaus, S-2900) and its isomer, N-[(S)-1-(2,4-dichlorophenyl)ethyl]-2-cyano-3,3-dimethylbutanamide (S-2900S), in rats. 1. Identification of metabolites in feces and urine.
Journal of agricultural and food chemistry 2006;54(12):4333-42.
2004: Hirokazu Tarui; Yoshitaka Tomigahara; Masayoshi Matsui; Naohiko Isobe; Hideo Kaneko; Nobuyoshi Mikami
Metabolism of diethofencarb (isopropyl 3,4-diethoxyphenylcarbamate) in rats: identification of metabolites in urine.
Journal of agricultural and food chemistry 2004;52(3):538-44.
2004: Norihisa Ooe; Koichi Saito; Nobuyoshi Mikami; Iwao Nakatuka; Hideo Kaneko
Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression.
Molecular and cellular biology 2004;24(2):608-16.
2003: Kiyoshi Higashi; Yutaka Inagaki; Ko Fujimori; Atsuhito Nakao; Hideo Kaneko; Iwao Nakatsuka
Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3.
The Journal of biological chemistry 2003;278(44):43470-9.
2003: Kiyoshi Higashi; Yutaka Inagaki; Noriyuki Suzuki; Shinichi Mitsui; Alain Mauviel; Hideo Kaneko; Iwao Nakatsuka
Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma.
The Journal of biological chemistry 2003;278(7):5156-62.
2003: Hiroshi Kato; Masahiko Okamoto; Kazuko Yamashita; Yosuke Nakamura; Yoshihiro Fukumori; Kiyoshi Nakai; Hideo Kaneko
Peptide-binding assessment using mass spectrometry as a new screening method for skin sensitization.
The Journal of toxicological sciences 2003;28(1):19-24.
2003: Kayo Sumida; Norihisa Ooe; Koichi Saito; Hideo Kaneko
Limited species differences in estrogen receptor alpha-medicated reporter gene transactivation by xenoestrogens.
The Journal of steroid biochemistry and molecular biology 2003;84(1):33-40.
2001: M Hayashi; K Higashi; Hiroshi Kato; Hideo Kaneko
Assessment of preferential Th1 or Th2 induction by low-molecular-weight compounds using a reverse transcription-polymerase chain reaction method: comparison of two mouse strains, C57BL/6 and BALB/c.
Toxicology and applied pharmacology 2001;177(1):38-45.
2001: Kayo Sumida; Norihisa Ooe; Koichi Saito; Hideo Kaneko
Molecular cloning and characterization of reptilian estrogen receptor cDNAs.
Molecular and cellular endocrinology 2001;183(1-2):33-9.
2001: H Nagahori; K Komai; Yoshitaka Tomigahara; Koichi Saito; Naohiko Isobe; Hideo Kaneko
Initial induction and subsequent reduction of alpha(2u)-globulin in urine and serum of mature male rats after repeated intraperitoneal injections of (anti)estrogen.
Toxicology 2001;162(2):73-80.
2001: Kayo Sumida; Norihisa Ooe; H Nagahori; Koichi Saito; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka
An in vitro reporter gene assay method incorporating metabolic activation with human and rat S9 or liver microsomes.
Biochemical and biophysical research communications 2001;280(1):85-91.
2001: Kayo Sumida; Koichi Saito; Norihisa Ooe; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka
Evaluation of in vitro methods for detecting the effects of various chemicals on the human progesterone receptor, with a focus on pyrethroid insecticides.
Toxicology letters 2001;118(3):147-55.
2000: T Yamada; K Odawara; Hideo Kaneko
Concurrent detection of gene mutations and chromosome aberrations induced by five chemicals in a CHL/IU cell line incorporating a gpt shuttle vector.
Mutation research 2000;471(1-2):29-36.
2000: H Nagahori; H Yoshino; Yoshitaka Tomigahara; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka
Metabolism of furametpyr. 2. (14)C excretion, (14)C concentrations in tissues, and amounts of metabolites in rats.
Journal of agricultural and food chemistry 2000;48(11):5760-7.
2000: H Nagahori; H Yoshino; Yoshitaka Tomigahara; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka
Metabolism of furametpyr. 1. Identification of metabolites and in vitro biotransformation in rats and humans.
Journal of agricultural and food chemistry 2000;48(11):5754-9.
2000: Koichi Saito; Yoshitaka Tomigahara; N Ohe; Naohiko Isobe; Iwao Nakatsuka; Hideo Kaneko
Lack of significant estrogenic or antiestrogenic activity of pyrethroid insecticides in three in vitro assays based on classic estrogen receptor alpha-mediated mechanisms.
Toxicological sciences : an official journal of the Society of Toxicology 2000;57(1):54-60.
2000: Yoshitaka Tomigahara; M Onogi; Koichi Saito; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka
Metabolism of Cyanox in rat. II. Sex-related differences in oxidative dearylation and desulphuration.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(4):395-406.
1999: Yoshitaka Tomigahara; M Onogi; Hideo Kaneko; Iwao Nakatsuka; S Yamane
Metabolism of 7-fluoro-6-(3,4,5,6-tetrahydrophthalimido)-4- (2-propynyl)-2H-1,4-benzoxazin-3(4H)-one (S-53482, flumioxazin) in the rat: II. Identification of reduced metabolites.
Journal of agricultural and food chemistry 1999;47(6):2429-38.
1999: Setsuko Komuro; M Sato; Hiroshi Kanamaru; Hideo Kaneko; Iwao Nakatsuka; A Yoshitake
In vivo and in vitro pharmacokinetics and metabolism studies of 26,26,26,27,27,27-F6-1,25(OH)2 vitamin D3 (Falecalcitriol) in rat: induction of vitamin D3-24-hydroxylase (CYP24) responsible for 23S-hydroxylation in target tissues and the drop in serum levels.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(6):603-13.
1999: T Yamada; R Yamamoto; Hideo Kaneko; A Yoshitake
Ethylnitrosourea-induced mutation and molecular analysis of transgenic mice containing the gpt shuttle vector.
Mutation research 1999;441(1):59-72.
1999: Yoshitaka Tomigahara; M Matsui; H Matsunaga; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka; A Yoshitake; S Yamane
Metabolism of 7-fluoro-6-(3,4,5,6-tetrahydrophthalimido)-4- (2-propynyl)-2H-1,4-benzoxazin-3(4H)-one (S-53482) in rat. 1. Identification of a sulfonic acid type conjugate.
Journal of agricultural and food chemistry 1999;47(1):305-12.
1997: Yoshitaka Tomigahara; M Onogi; Koichi Saito; Hideo Kaneko; Iwao Nakatsuka; S Yamane
Metabolism of tetramethrin isomers in rat: IV. Tissues responsible for formation of reduced and hydrated metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 1997;27(9):961-71.
1996: Yoshitaka Tomigahara; M Onogi; M Miki; K Yanagi; K Shiba; Hideo Kaneko; Iwao Nakatsuka; H Yamada
Metabolism of tetramethrin isomers in rat. III. Stereochemistry of reduced metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(2):201-10.
1996: K Saito; S Uwagawa; Hideo Kaneko; K Shiba; Yoshitaka Tomigahara; Iwao Nakatsuka
Alpha 2u-globulins in the urine of male rats: a reliable indicator for alpha 2u-globulin accumulation in the kidney.
Toxicology 1996;106(1-3):149-57.
1995: Yoshitaka Tomigahara; M Onogi; K Saito; K Shiba; Hideo Kaneko; Iwao Nakatsuka; H Yamada
Metabolism of Cyanox in the rat. I. Absorption, disposition, excretion and biotransformation.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(11):1195-206.
1994: Yoshitaka Tomigahara; M Mori; K Shiba; N Isobe; Hideo Kaneko; Iwao Nakatsuka; H Yamada
Metabolism of tetramethrin isomers in rat: II. Identification and quantitation of metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(12):1205-14.
1994: Yoshitaka Tomigahara; K Shiba; N Isobe; Hideo Kaneko; Iwao Nakatsuka; H Yamada
Identification of two new types of S-linked conjugates of Etoc in rat.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(9):839-52.
1994: Yoshitaka Tomigahara; M Mori; K Shiba; N Isobe; Hideo Kaneko; Iwao Nakatsuka; H Yamada
Metabolism of tetramethrin isomers in rat. I. Identification of a sulphonic acid type of conjugate and reduced metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(5):473-84.
1993: H Yoshino; Hideo Kaneko; Iwao Nakatsuka; H Yamada
Metabolism of N-[4-chloro-2-fluoro-5-[(1-methyl-2-propynyl)oxy]phenyl]-3,4,5,6- tetrahydrophthalimide (S-23121) in the rat. II. Absorption, disposition, excretion and biotransformation.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(10):1075-84.
1993: H Yoshino; H Matsunaga; Hideo Kaneko; A Yoshitake; Iwao Nakatsuka; H Yamada
Metabolism of N-[4-chloro-2-fluoro-5-[(1-methyl-2- propynl)oxy]phenyl]-3,4,5,6-tetrahydrophthalimide (S-23121) in the rat: I. Identification of a new, sulphonic acid type of conjugate.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(6):609-19.
1992: K Saito; Hideo Kaneko; N Isobe; Iwao Nakatsuka; A Yoshitake; H Yamada
Differences in alpha 2u-globulins increased in male rat kidneys following treatment with several alpha 2u-globulin accumulating agents: cystein protease(s) play(s) an important role in production of kidney-type-alpha 2u-globulin.
Toxicology 1992;76(2):177-86.
1992: Hideo Kaneko; S Kawaguchi; Y Misaki; Y Koyama; A Nakayama; H Kawasaki; A Hirohashi; A Yoshitake; H Yamada
[Mammalian toxicity of empenthrin (Vaporthrin, S-2852F)].
The Journal of toxicological sciences 1992;17 Suppl 3():313-34.
1991: K Saito; Hideo Kaneko; K Sato; A Yoshitake; H Yamada
Age-related changes in metabolism of diethofencarb: relationship between metabolism in rat and hepatic drug-metabolizing enzyme activities.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(5):575-82.
1991: K Saito; S Uwagawa; Hideo Kaneko; A Yoshitake
Behavior of alpha 2u-globulin accumulating in kidneys of male rats treated with d-limonene: kidney-type alpha 2u-globulin in the urine as a marker of d-limonene nephropathy.
Toxicology 1991;70(2):173-83.
1988: Masao Hirose; A Hagiwara; K Inoue; Nobuyuki Ito; Hideo Kaneko; K Saito; H Matsunaga; N Isobe; A Yoshitake; J Miyamoto
Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole in the rat (III): Metabolites in the urine and feces.
Toxicology 1988;53(1):33-43.