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Anna Kanerva

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Anna Kanerva; Lotta Kangasniemi; Antti Koski; Leena Laasonen; Ilkka Liikanen; Petri Nokisalmi; Minna Oksanen; Kaarina Partanen; Sari Pesonen; Saila Pesonen; Siri Tähtinen; Tuomo Alanko; Vincenzo Cerullo; Iulia Diaconu; Raita Heiskanen; Timo Joensuu; Kalevi Kairemo; Akseli Hemminki
Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF-Coding Oncolytic Adenovirus.
Antti Koski; Sophie Escutenaire; Anna Kanerva; Eerika Karli; Anja Kipar; Akseli Hemminki
Mutation of the fiber shaft heparan sulphate binding site of a 5/3 chimeric adenovirus reduces liver tropism.
Vincenzo Cerullo; Iulia Diaconu; Sophie Escutenaire; Mari Hirvinen; Sirkka-Liisa Holm; Anna Kanerva; Anja Kipar; Valentina Romano; Matteo Ugolini; Akseli Hemminki
An oncolytic adenovirus enhanced for toll-like receptor 9 stimulation increases antitumor immune responses and tumor clearance.

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All Publications

2013: Anna Kanerva; Lotta Kangasniemi; Antti Koski; Leena Laasonen; Ilkka Liikanen; Petri Nokisalmi; Minna Oksanen; Kaarina Partanen; Sari Pesonen; Saila Pesonen; Siri Tähtinen; Tuomo Alanko; Vincenzo Cerullo; Iulia Diaconu; Raita Heiskanen; Timo Joensuu; Kalevi Kairemo; Akseli Hemminki
Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF-Coding Oncolytic Adenovirus.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(10):2734-44.
2013: Antti Koski; Sophie Escutenaire; Anna Kanerva; Eerika Karli; Anja Kipar; Akseli Hemminki
Mutation of the fiber shaft heparan sulphate binding site of a 5/3 chimeric adenovirus reduces liver tropism.
PloS one 2013;8(4):e60032.
2012: Vincenzo Cerullo; Iulia Diaconu; Sophie Escutenaire; Mari Hirvinen; Sirkka-Liisa Holm; Anna Kanerva; Anja Kipar; Valentina Romano; Matteo Ugolini; Akseli Hemminki
An oncolytic adenovirus enhanced for toll-like receptor 9 stimulation increases antitumor immune responses and tumor clearance.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(11):2076-86.
2012: J D Dias; Sophie Escutenaire; Kilian Guse; O Hemminki; M Hirvinen; Anna Kanerva; A Löskog; S Pesonen; A Bonetti; Vincenzo Cerullo; I Diaconu; Akseli Hemminki
Targeted cancer immunotherapy with oncolytic adenovirus coding for a fully human monoclonal antibody specific for CTLA-4.
Gene therapy 2012;19(10):988-98.
2012: Otto Hemminki; Timo Joensuu; Kalevi Kairemo; Anna Kanerva; Lotta Kangasniemi; Leena Laasonen; Andre Lieber; Kaarina Partanen; Sari Pesonen; Saila K Pesonen; Vincenzo Cerullo; Iulia Diaconu; Akseli Hemminki
Ad3-hTERT-E1A, a fully serotype 3 oncolytic adenovirus, in patients with chemotherapy refractory cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(9):1821-30.
2012: Lotta Kangasniemi; Tuula Kiviluoto; Antti Koski; Mika Koskinen; Suvi Parviainen; Sari Pesonen; Tommi Pisto; Harry Jalonen; Mika Jokinen; Anna Kanerva; Anna Kangasniemi; Vincenzo Cerullo; Akseli Hemminki
Effects of capsid-modified oncolytic adenoviruses and their combinations with gemcitabine or silica gel on pancreatic cancer.
International journal of cancer. Journal international du cancer 2012;131(1):253-63.
2012: Iulia Diaconu; Aristides G Eliopoulos; Sophie Escutenaire; Mari L M Hirvinen; Anna Kanerva; Angelica S I Loskog; Suvi Parviainen; Sari Pesonen; Saila K Pesonen; Matteo Ugolini; Simona Bramante; Vincenzo Cerullo; Akseli Hemminki
Immune response is an important aspect of the antitumor effect produced by a CD40L-encoding oncolytic adenovirus.
Cancer research 2012;72(9):2327-38.
2012: Sari Pesonen; Mari Raki; Vincenzo Cerullo; Iulia Diaconu; Gianpietro Dotti; Sophie Escutenaire; Kilian Guse; Elina Haavisto; Päivi Hannuksela; Sirkka-Liisa Holm; Timo Joensuu; Anna Kanerva; Lotta Kangasniemi; Aila Karioja-Kallio; Eerika Karli; Satu Kauppinen; Leena Laasonen; Petri Nokisalmi; Minna Oksanen; Kaarina Partanen; Akseli Hemminki
Integrin targeted oncolytic adenoviruses Ad5-D24-RGD and Ad5-RGD-D24-GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors.
International journal of cancer. Journal international du cancer 2012;130(8):1937-47.
2012: Sari Pesonen; Saila K Pesonen; Tuuli Ranki; Tuomo Alanko; Vincenzo Cerullo; Iulia Diaconu; Ulrike Gerdemann; Elina Haavisto; Sirkka-Liisa Holm; Timo Joensuu; Kalevi Kairemo; Anna Kanerva; Lotta Kangasniemi; Aila Karioja-Kallio; Satu Kauppinen; Leena Laasonen; Ann Leen; Minna Oksanen; Kaarina P L Partanen; Akseli Hemminki
Oncolytic immunotherapy of advanced solid tumors with a CD40L-expressing replicating adenovirus: assessment of safety and immunologic responses in patients.
Cancer research 2012;72(7):1621-31.
2012: Maria Rajecki; Mirkka Sarparanta; Mikko Tenhunen; Kalevi Kairemo; Anna Kanerva; Venla Kuhmonen; Anu J Airaksinen; Iulia Diaconu; Tanja Hakkarainen; Akseli Hemminki
SPECT/CT imaging of hNIS-expression after intravenous delivery of an oncolytic adenovirus and 131I.
PloS one 2012;7(3):e32871.
2011: Ilkka Liikanen; Daniela Marzioni; Vladia Monsurrò; Sari Pesonen; Mari Raki; Otto Hemminki; Anna Kanerva; Laura Ahtiainen; Vincenzo Cerullo; Marco Colombatti; Iulia Diaconu; João D Dias; Sophie Escutenaire; Tanja Hakkarainen; Akseli Hemminki
Induction of interferon pathways mediates in vivo resistance to oncolytic adenovirus.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(10):1858-66.
2011: Vincenzo Cerullo; Iulia Diaconu; Sophie Escutenaire; Elina Haavisto; Petteri T Arstila; Sirkka-Liisa Holm; Timo Joensuu; Anna Kanerva; Lotta Kangasniemi; Aila Karioja-Kallio; Satu Kauppinen; Antti Koski; Leena Laasonen; Minna Oksanen; Kaarina Partanen; Sari Pesonen; Maria Rajecki; Valentina Romano; Noora Rouvinen; Tamara Tuuminen; Akseli Hemminki
Immunological effects of low-dose cyclophosphamide in cancer patients treated with oncolytic adenovirus.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(9):1737-46.
2011: Mari Raki; Merja Sarkioja; Vincenzo Cerullo; Sophie Escutenaire; Elina Haavisto; Timo Joensuu; Anna Kanerva; Lotta Kangasniemi; Minna Oksanen; Sari Pesonen; Akseli Hemminki
Switching the fiber knob of oncolytic adenoviruses to avoid neutralizing antibodies in human cancer patients.
The journal of gene medicine 2011;13(5):253-61.
2011: O Hemminki; Gerd J Bauerschmitz; S Hemmi; S Lavilla-Alonso; I Diaconu; Kilian Guse; Antti Koski; Renee A Desmond; M Lappalainen; Anna Kanerva; Vincenzo Cerullo; S Pesonen; Akseli Hemminki
Oncolytic adenovirus based on serotype 3.
Cancer gene therapy 2011;18(4):288-96.
2011: Sophie Escutenaire; Vincenzo Cerullo; Iulia Diaconu; Laura Ahtiainen; Päivi Hannuksela; Minna Oksanen; Elina Haavisto; Aila Karioja-Kallio; Sirkka-Liisa Holm; Lotta Kangasniemi; Camilla Ribacka; Satu Kauppinen; Timo Joensuu; T Petteri Arstila; Sari Pesonen; Anna Kanerva; Akseli Hemminki
In vivo and in vitro distribution of type 5 and fiber-modified oncolytic adenoviruses in human blood compartments.
Annals of medicine 2011;43(2):151-63.
2011: Maria Rajecki; Mari Raki; Sophie Escutenaire; Sari Pesonen; Vincenzo Cerullo; Andreas Helminen; Päivi Hannuksela; Kaarina Partanen; Leena Laasonen; Timo Joensuu; Lotta Kangasniemi; Elina Haavisto; Anna Kanerva; Laura Ahtiainen; Akseli Hemminki
Safety of glucocorticoids in cancer patients treated with oncolytic adenoviruses.
Molecular pharmaceutics 2011;8(1):93-103.
2011: Sergio Lavilla-Alonso; Kalle Saksela; Turgut Tatlisumak; Usama Abo Ramadan; Sophie Escutenaire; Juha Halavaara; Akseli Hemminki; Anna Kanerva; Sari Pesonen
Optimized mouse model for the imaging of tumor metastasis upon experimental therapy.
PloS one 2011;6(11):e26810.
2010: Ilkka Liikanen; João D Dias; Petri Nokisalmi; Marta Sloniecka; Lotta Kangasniemi; Maria Rajecki; Thomas Dobner; Mikko Tenhunen; Anna Kanerva; Sari Pesonen; Laura Ahtiainen; Akseli Hemminki
Adenoviral E4orf3 and E4orf6 proteins, but not E1B55K, increase killing of cancer cells by radiotherapy in vivo.
International journal of radiation oncology, biology, physics 2010;78(4):1201-9.
2010: Anniina Koski; Lotta Kangasniemi; Sophie Escutenaire; Sari Pesonen; Vincenzo Cerullo; Iulia Diaconu; Petri Nokisalmi; Mari Raki; Maria Rajecki; Kilian Guse; Tuuli Ranki; Minna Oksanen; Sirkka-Liisa Holm; Elina Haavisto; Aila Karioja-Kallio; Leena Laasonen; Kaarina Partanen; Matteo Ugolini; Andreas Helminen; Eerika Karli; Päivi Hannuksela; Saila Pesonen; Timo Joensuu; Anna Kanerva; Akseli Hemminki
Treatment of cancer patients with a serotype 5/3 chimeric oncolytic adenovirus expressing GMCSF.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(10):1874-84.
2010: S Pesonen; P Nokisalmi; Sophie Escutenaire; Merja Särkioja; Mari Raki; Vincenzo Cerullo; Lotta Kangasniemi; Leena Laasonen; Camilla Ribacka; Kilian Guse; E Haavisto; M Oksanen; Maria Rajecki; A Helminen; Ari Ristimäki; A Karioja-Kallio; E Karli; T Kantola; Gerd J Bauerschmitz; Anna Kanerva; Timo Joensuu; Akseli Hemminki
Prolonged systemic circulation of chimeric oncolytic adenovirus Ad5/3-Cox2L-D24 in patients with metastatic and refractory solid tumors.
Gene therapy 2010;17(7):892-904.
2010: Petri Nokisalmi; Sari Pesonen; Sophie Escutenaire; Merja Särkioja; Mari Raki; Vincenzo Cerullo; Leena Laasonen; Ramon Alemany; Juan Rojas; Manel Cascallo; Kilian Guse; Maria Rajecki; Lotta Kangasniemi; Elina Haavisto; Aila Karioja-Kallio; Päivi Hannuksela; Minna Oksanen; Anna Kanerva; Timo Joensuu; Laura Ahtiainen; Akseli Hemminki
Oncolytic adenovirus ICOVIR-7 in patients with advanced and refractory solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(11):3035-43.
2010: Vincenzo Cerullo; Sari Pesonen; Iulia Diaconu; Sophie Escutenaire; Petteri T Arstila; Matteo Ugolini; Petri Nokisalmi; Mari Raki; Leena Laasonen; Merja Särkioja; Maria Rajecki; Lotta Kangasniemi; Kilian Guse; Andreas Helminen; Laura Ahtiainen; Ari Ristimäki; Anne Räisänen-Sokolowski; Elina Haavisto; Minna Oksanen; Eerika Karli; Aila Karioja-Kallio; Sirkka-Liisa Holm; Mauri Kouri; Timo Joensuu; Anna Kanerva; Akseli Hemminki
Oncolytic adenovirus coding for granulocyte macrophage colony-stimulating factor induces antitumoral immunity in cancer patients.
Cancer research 2010;70(11):4297-309.
2010: Iulia Diaconu; Vincenzo Cerullo; Sophie Escutenaire; Anna Kanerva; Gerd J Bauerschmitz; Ruben Hernandez-Alcoceba; Sari Pesonen; Akseli Hemminki
Human adenovirus replication in immunocompetent Syrian hamsters can be attenuated with chlorpromazine or cidofovir.
The journal of gene medicine 2010;12(5):435-45.
2010: João D Dias; Ilkka Liikanen; Kilian Guse; Johann Foloppe; Marta Sloniecka; Iulia Diaconu; Ville Rantanen; Minna Eriksson; Tanja Hakkarainen; Monika Lusky; Philippe Erbs; Sophie Escutenaire; Anna Kanerva; Sari Pesonen; Vincenzo Cerullo; Akseli Hemminki
Targeted chemotherapy for head and neck cancer with a chimeric oncolytic adenovirus coding for bifunctional suicide protein FCU1.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(9):2540-9.
2010: Laura Ahtiainen; Cristina Mirantes; Tiina Jahkola; Sophie Escutenaire; Iulia Diaconu; Pamela Osterlund; Anna Kanerva; Vincenzo Cerullo; Akseli Hemminki
Defects in innate immunity render breast cancer initiating cells permissive to oncolytic adenovirus.
PloS one 2010;5(11):e13859.
2010: Marko T Ahonen; Iulia Diaconu; Sari Pesonen; Anna Kanerva; Marc Baumann; Suvi T Parviainen; Brad Spiller; Vincenzo Cerullo; Akseli Hemminki
Calcium gluconate in phosphate buffered saline increases gene delivery with adenovirus type 5.
PloS one 2010;5(9):.
2010: Sergio Lavilla-Alonso; Gerd J Bauerschmitz; Usama Abo Ramadan; Juha Halavaara; Sophie Escutenaire; Iulia Diaconu; Turgut Tatlisumak; Anna Kanerva; Akseli Hemminki; Sari Pesonen
Adenoviruses with an αvβ integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases.
Journal of translational medicine 2010;8():80.
2010: Sari Pesonen; Heikki Helin; Petri Nokisalmi; Sophie Escutenaire; Camilla Ribacka; Merja Sarkioja; Vincenzo Cerullo; Kilian Guse; Gerd Bauerschmitz; Leena Laasonen; T Kantola; Ari Ristimaki; Maria Rajecki; Minna Oksanen; Elina Haavisto; Anna Kanerva; Timo Joensuu; Akseli Hemminki
Oncolytic adenovirus treatment of a patient with refractory neuroblastoma.
Acta oncologica (Stockholm, Sweden) 2010;49(1):117-9.
2009: Maria Rajecki; Taija af Hällström; Tanja Hakkarainen; Petri Nokisalmi; Sampsa Hautaniemi; Anni I Nieminen; Mikko Tenhunen; Ville Rantanen; Renee A Desmond; Dung-Tsa Chen; Kilian Guse; Ulf-Håkan Stenman; Ricardo Gargini; Mika Kapanen; Juha Klefström; Anna Kanerva; Sari Pesonen; Laura Ahtiainen; Akseli Hemminki
Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation.
International journal of cancer. Journal international du cancer 2009;125(10):2441-9.
2009: Anniina Koski; Maria Rajecki; Kilian Guse; Anna Kanerva; Ari Ristimäki; Sari Pesonen; Sophie Escutenaire; Akseli Hemminki
Systemic adenoviral gene delivery to orthotopic murine breast tumors with ablation of coagulation factors, thrombocytes and Kupffer cells.
The journal of gene medicine 2009;11(11):966-77.
2009: Kilian Guse; I Diaconu; Maria Rajecki; M Sloniecka; Tanja Hakkarainen; Ari Ristimäki; Anna Kanerva; S Pesonen; Akseli Hemminki
Ad5/3-9HIF-Delta24-VEGFR-1-Ig, an infectivity enhanced, dual-targeted and antiangiogenic oncolytic adenovirus for kidney cancer treatment.
Gene therapy 2009;16(8):1009-20.
2009: Iulia Diaconu; Laura Denby; Sari Pesonen; Vincenzo Cerullo; Gerd J Bauerschmitz; Kilian Guse; Maria Rajecki; João D Dias; Kimmo Taari; Anna Kanerva; Andrew H Baker; Akseli Hemminki
Serotype chimeric and fiber-mutated adenovirus Ad5/19p-HIT for targeting renal cancer and untargeting the liver.
Human gene therapy 2009;20(6):611-20.
2009: Lotta Kangasniemi; M Koskinen; M Jokinen; M Toriseva; R Ala-Aho; Veli-Matti Kähäri; H Jalonen; Seppo Ylä-Herttuala; H Moilanen; Ulf-Hakan Stenman; I Diaconu; Anna Kanerva; S Pesonen; Tanja Hakkarainen; Akseli Hemminki
Extended release of adenovirus from silica implants in vitro and in vivo.
Gene therapy 2009;16(1):103-10.
2008: Gerd J Bauerschmitz; Tuuli Ranki; Lotta Kangasniemi; Camilla Ribacka; Minna Eriksson; Marius Porten; Isabell Herrmann; Ari Ristimäki; Pekka Virkkunen; Maija Tarkkanen; Tanja Hakkarainen; Anna Kanerva; Daniel Rein; Sari Pesonen; Akseli Hemminki
Tissue-specific promoters active in CD44+CD24-/low breast cancer cells.
Cancer research 2008;68(14):5533-9.
2008: Merja Särkioja; Tanja Hakkarainen; Minna Eriksson; Ari Ristimäki; Renee A Desmond; Anna Kanerva; Akseli Hemminki
The cyclo-oxygenase 2 promoter is induced in nontarget cells following adenovirus infection, but an AU-rich 3'-untranslated region destabilization element can increase specificity.
The journal of gene medicine 2008;10(7):744-53.
2008: Merja Särkioja; S Pesonen; Mari Raki; Tanja Hakkarainen; Jarmo Salo; M T Ahonen; Anna Kanerva; Akseli Hemminki
Changing the adenovirus fiber for retaining gene delivery efficacy in the presence of neutralizing antibodies.
Gene therapy 2008;15(12):921-9.
2008: Anna Kanerva; Sergio Lavilla-Alonso; Mari Raki; Lotta Kangasniemi; Gerd J Bauerschmitz; Koichi Takayama; Ari Ristimäki; Renee A Desmond; Akseli Hemminki
Systemic therapy for cervical cancer with potentially regulatable oncolytic adenoviruses.
PloS one 2008;3(8):e2917.
2008: Mari Raki; Merja Särkioja; Renee A Desmond; Dung-Tsa Chen; Ralf Bützow; Akseli Hemminki; Anna Kanerva
Oncolytic adenovirus Ad5/3-delta24 and chemotherapy for treatment of orthotopic ovarian cancer.
Gynecologic oncology 2008;108(1):166-72.
2007: Minna Eriksson; Kilian Guse; Gerd J Bauerschmitz; Pekka Virkkunen; Maija Tarkkanen; Minna Tanner; Tanja Hakkarainen; Anna Kanerva; Renee A Desmond; Sari Pesonen; Akseli Hemminki
Oncolytic adenoviruses kill breast cancer initiating CD44+CD24-/low cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2088-93.
2007: Kilian Guse; Tuuli Ranki; Martti Ala-Opas; Petri Bono; Merja Särkioja; Maria Rajecki; Anna Kanerva; Tanja Hakkarainen; Akseli Hemminki
Treatment of metastatic renal cancer with capsid-modified oncolytic adenoviruses.
Molecular cancer therapeutics 2007;6(10):2728-36.
2007: Mari Raki; Tanja Hakkarainen; Gerd J Bauerschmitz; Merja Särkioja; Renee A Desmond; Anna Kanerva; Akseli Hemminki
Utility of TK/GCV in the context of highly effective oncolysis mediated by a serotype 3 receptor targeted oncolytic adenovirus.
Gene therapy 2007;14(19):1380-8.
2007: Anna Kanerva; Mari Raki; Akseli Hemminki
Gene therapy of gynaecological diseases.
Expert opinion on biological therapy 2007;7(9):1347-61.
2007: Tanja Hakkarainen; Merja Särkioja; Petri Lehenkari; Susanna Miettinen; Timo Ylikomi; Riitta Suuronen; Renee A Desmond; Anna Kanerva; Akseli Hemminki
Human mesenchymal stem cells lack tumor tropism but enhance the antitumor activity of oncolytic adenoviruses in orthotopic lung and breast tumors.
Human gene therapy 2007;18(7):627-41.
2007: Tuuli Ranki; Merja Särkioja; Tanja Hakkarainen; Karl von Smitten; Anna Kanerva; Akseli Hemminki
Systemic efficacy of oncolytic adenoviruses in imagable orthotopic models of hormone refractory metastatic breast cancer.
International journal of cancer. Journal international du cancer 2007;121(1):165-74.
2007: Kilian Guse; J D Dias; Gerd J Bauerschmitz; Tanja Hakkarainen; Einari Aavik; Tuuli Ranki; T Pisto; Merja Särkioja; Renee A Desmond; Anna Kanerva; Akseli Hemminki
Luciferase imaging for evaluation of oncolytic adenovirus replication in vivo.
Gene therapy 2007;14(11):902-11.
2007: John T Lam; Akseli Hemminki; Anna Kanerva; K B Lee; Jerry L Blackwell; Renee A Desmond; Gene P Siegal; David T Curiel
A three-dimensional assay for measurement of viral-induced oncolysis.
Cancer gene therapy 2007;14(4):421-30.
2007: Maria Rajecki; Anna Kanerva; Ulf-Hakan Stenman; Mikko Tenhunen; Lotta Kangasniemi; Merja Särkioja; Martti Ala-Opas; Henrik Alfthan; Anna Sankila; Erkki Rintala; Renee A Desmond; Tanja Hakkarainen; Akseli Hemminki
Treatment of prostate cancer with Ad5/3Delta24hCG allows non-invasive detection of the magnitude and persistence of virus replication in vivo.
Molecular cancer therapeutics 2007;6(2):742-51.
2007: Anna Kanerva; Mari Raki; Tuuli Ranki; Merja Särkioja; Jarmo Koponen; Renee A Desmond; Aija Helin; Ulf-Hakan Stenman; Helena Isoniemi; Krister Höckerstedt; Ari Ristimäki; Akseli Hemminki
Chlorpromazine and apigenin reduce adenovirus replication and decrease replication associated toxicity.
The journal of gene medicine 2007;9(1):3-9.
2007: Tuuli Ranki; Anna Kanerva; Ari Ristimäki; Tanja Hakkarainen; Merja Särkioja; Lotta Kangasniemi; Mari Raki; Pirjo Laakkonen; S Goodison; Akseli Hemminki
A heparan sulfate-targeted conditionally replicative adenovirus, Ad5.pk7-Delta24, for the treatment of advanced breast cancer.
Gene therapy 2007;14(1):58-67.
2006: Merja Sarkioja; Anna Kanerva; Jarmo Salo; Lotta Kangasniemi; Minna Eriksson; Mari Raki; Tuuli Ranki; Tanja Hakkarainen; Akseli Hemminki
Noninvasive imaging for evaluation of the systemic delivery of capsid-modified adenoviruses in an orthotopic model of advanced lung cancer.
Cancer 2006;107(7):1578-88.
2006: Mari Raki; Daniel T Rein; Anna Kanerva; Akseli Hemminki
Gene transfer approaches for gynecological diseases.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(2):154-63.
2006: Gerd J Bauerschmitz; Kilian Guse; Anna Kanerva; Artur Menzel; Isabell Herrmann; Renee A Desmond; Masato Yamamoto; Dirk M Nettelbeck; Tanja Hakkarainen; Peter Dall; David T Curiel; Akseli Hemminki
Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, E1A transcomplementation, and serotype chimerism for enhanced selectivity for ovarian cancer cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(2):164-74.
2006: Lotta Kangasniemi; Tuula Kiviluoto; Anna Kanerva; Mari Raki; Tuuli Ranki; Merja Sarkioja; Hongju Wu; Frank Marini; Krister Höckerstedt; Helena Isoniemi; Henrik Alfthan; Ulf-Hakan Stenman; David T Curiel; Akseli Hemminki
Infectivity-enhanced adenoviruses deliver efficacy in clinical samples and orthotopic models of disseminated gastric cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(10):3137-44.
2005: Mari Raki; Anna Kanerva; Ari Ristimaki; Renee A Desmond; Dung-Tsa Chen; Tuuli Ranki; Merja Sarkioja; Lotta Kangasniemi; Akseli Hemminki
Combination of gemcitabine and Ad5/3-Delta24, a tropism modified conditionally replicating adenovirus, for the treatment of ovarian cancer.
Gene therapy 2005;12(15):1198-205.
2005: Tanja Hakkarainen; Anna Kanerva; Akseli Hemminki
[Adenoviruses in cancer therapy].
Duodecim; lääketieteellinen aikakauskirja 2005;121(20):2195-203.
2005: Anna Kanerva; Akseli Hemminki
Adenoviruses for treatment of cancer.
Annals of medicine 2005;37(1):33-43.
2005: Anna Kanerva; Kurt R Zinn; K-W Peng; Tuuli Ranki; Lotta Kangasniemi; T R Chaudhuri; Renee A Desmond; M Wang; K Takayama; Tanja Hakkarainen; Henrik Alfthan; Ulf-Hakan Stenman; David T Curiel; Akseli Hemminki
Noninvasive dual modality in vivo monitoring of the persistence and potency of a tumor targeted conditionally replicating adenovirus.
Gene therapy 2005;12(1):87-94.
2004: John T Lam; Anna Kanerva; Gerd J Bauerschmitz; Koichi Takayama; Kaori Suzuki; Masato Yamamoto; Snehal M Bhoola; Bin Liu; Minghui Wang; Mack N Barnes; Ronald D Alvarez; Gene P Siegal; David T Curiel; Akseli Hemminki
Inter-patient variation in efficacy of five oncolytic adenovirus candidates for ovarian cancer therapy.
The journal of gene medicine 2004;6(12):1333-42.
2004: Gerd J Bauerschmitz; Anna Kanerva; Minghui Wang; Isabell Herrmann; Denise R Shaw; Theresa V Strong; Renee A Desmond; Daniel T Rein; Peter Dall; David T Curiel; Akseli Hemminki
Evaluation of a selectively oncolytic adenovirus for local and systemic treatment of cervical cancer.
International journal of cancer. Journal international du cancer 2004;111(2):303-9.
2004: Anna Kanerva; Akseli Hemminki
Modified adenoviruses for cancer gene therapy.
International journal of cancer. Journal international du cancer 2004;110(4):475-80.
2004: Anna Kanerva; Gerd J Bauerschmitz; Masato Yamamoto; John T Lam; Ronald D Alvarez; Gene P Siegal; David T Curiel; Akseli Hemminki
A cyclooxygenase-2 promoter-based conditionally replicating adenovirus with enhanced infectivity for treatment of ovarian adenocarcinoma.
Gene therapy 2004;11(6):552-9.
2003: Andrea L Volk; Angel A Rivera; Anna Kanerva; Gerd J Bauerschmitz; Igor Dmitriev; Dirk M Nettelbeck; David T Curiel
Enhanced adenovirus infection of melanoma cells by fiber-modification: incorporation of RGD peptide or Ad5/3 chimerism.
Cancer biology & therapy 2003;2(5):511-5.
2003: Anna Kanerva; Kurt R Zinn; Tandra R Chaudhuri; John T Lam; Kaori Suzuki; taco uil; Tanja Hakkarainen; Gerd J Bauerschmitz; Minghui Wang; Bin Liu; Zhihong Cao; Ronald D Alvarez; David T Curiel; Akseli Hemminki
Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirus.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(3):449-58.
2003: John T Lam; Gerd J Bauerschmitz; Anna Kanerva; Shannon D Barker; J Michael Straughn; Minghui Wang; Mack N Barnes; Jerry L Blackwell; Gene P Siegal; Ronald D Alvarez; David T Curiel; Akseli Hemminki
Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroids.
Cancer gene therapy 2003;10(5):377-87.
2003: Shannon D Barker; Candace J Coolidge; Anna Kanerva; Tanja Hakkarainen; Masato Yamamoto; Bin Liu; Angel A Rivera; Snehal M Bhoola; Mack N Barnes; Ronald D Alvarez; David T Curiel; Akseli Hemminki
The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapy.
The journal of gene medicine 2003;5(4):300-10.
2003: Akseli Hemminki; Anna Kanerva; Bin Liu; Minghui Wang; Ronald D Alvarez; Gene P Siegal; David T Curiel
Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.
Cancer research 2003;63(4):847-53.
2003: Akseli Hemminki; Anna Kanerva; Eric J Kremer; Gerd J Bauerschmitz; Bruce F Smith; Bin Liu; Minghui Wang; Renee A Desmond; Anne Keriel; Brian G Barnett; Henry J Baker; Gene P Siegal; David T Curiel
A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(2):163-73.
2003: Tanja Hakkarainen; Akseli Hemminki; Alexander Pereboev; Shannon D Barker; Clement K Asiedu; Theresa V Strong; Anna Kanerva; Jarmo Wahlfors; David T Curiel
CD40 is expressed on ovarian cancer cells and can be utilized for targeting adenoviruses.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(2):619-24.
2002: Yosef S Haviv; Jerry L Blackwell; Anna Kanerva; Peter Nagi; Victor Krasnykh; Igor Dmitriev; Minghui Wang; Seiji Naito; Xiaosheng Lei; Akseli Hemminki; Delicia Carey; David T Curiel
Adenoviral gene therapy for renal cancer requires retargeting to alternative cellular receptors.
Cancer research 2002;62(15):4273-81.
2002: Anna Kanerva; Minghui Wang; Gerd J Bauerschmitz; John T Lam; Renee A Desmond; Snehal M Bhoola; Mack N Barnes; Ronald D Alvarez; Gene P Siegal; David T Curiel; Akseli Hemminki
Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(6):695-704.
2002: Gerd J Bauerschmitz; Dirk M Nettelbeck; Anna Kanerva; Andrew H Baker; Akseli Hemminki; Paul N Reynolds; David T Curiel
The flt-1 promoter for transcriptional targeting of teratocarcinoma.
Cancer research 2002;62(5):1271-4.
2002: Gerd J Bauerschmitz; John T Lam; Anna Kanerva; Kaori Suzuki; Dirk M Nettelbeck; Igor Dmitriev; Victor Krasnykh; Galina Mikheeva; Mack N Barnes; Ronald D Alvarez; Peter Dall; Ramon Alemany; David T Curiel; Akseli Hemminki
Treatment of ovarian cancer with a tropism modified oncolytic adenovirus.
Cancer research 2002;62(5):1266-70.
2002: Anna Kanerva; Galina Mikheeva; Victor Krasnykh; Candace J Coolidge; John T Lam; Parameshwar J Mahasreshti; Shannon D Barker; Michael Straughn; Mack N Barnes; Ronald D Alvarez; Akseli Hemminki; David T Curiel
Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(1):275-80.