Hideaki Kaneto

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Tanaka Ayako; Kaneto Hideaki; Miyatsuka Takeshi; Yamamoto Kaoru; Yoshiuchi Kazutomi; Yamasaki Yoshimitsu; Shimomura Iichiro; Matsuoka Taka-Aki; Matsuhisa Munehide
Role of copper ion in the pathogenesis of type 2 diabetes.
Kaneto Hideaki; Matsuoka Taka-Aki; Kawashima Satoshi; Yamamoto Kaoru; Kato Ken; Miyatsuka Takeshi; Katakami Naoto; Matsuhisa Munehide
Role of MafA in pancreatic beta-cells.
Katakami Naoto; Matsuhisa Munehide; Kaneto Hideaki; Matsuoka Taka-aki; Sakamoto Ken'ya; Yasuda Tetsuyuki; Umayahara Yutaka; Kosugi Keisuke; Yamasaki Yoshimitsu
Serum endogenous secretory RAGE level is an independent risk factor for the progression of carotid atherosclerosis in type 1 diabetes.

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All Publications

2009: Tanaka Ayako; Kaneto Hideaki; Miyatsuka Takeshi; Yamamoto Kaoru; Yoshiuchi Kazutomi; Yamasaki Yoshimitsu; Shimomura Iichiro; Matsuoka Taka-Aki; Matsuhisa Munehide
Role of copper ion in the pathogenesis of type 2 diabetes.
Endocrine journal 2009;56(5):699-706.
2009: Kaneto Hideaki; Matsuoka Taka-Aki; Kawashima Satoshi; Yamamoto Kaoru; Kato Ken; Miyatsuka Takeshi; Katakami Naoto; Matsuhisa Munehide
Role of MafA in pancreatic beta-cells.
Advanced drug delivery reviews 2009;61(7-8):489-96.
2009: Katakami Naoto; Matsuhisa Munehide; Kaneto Hideaki; Matsuoka Taka-aki; Sakamoto Ken'ya; Yasuda Tetsuyuki; Umayahara Yutaka; Kosugi Keisuke; Yamasaki Yoshimitsu
Serum endogenous secretory RAGE level is an independent risk factor for the progression of carotid atherosclerosis in type 1 diabetes.
Atherosclerosis 2009;204(1):288-92.
2009: Katakami N; Sakamoto K; Kaneto H; Matsuhisa M; Shimizu I; Ishibashi F; Osonoi T; Kashiwagi A; Kawamori R; Hori M; Yamasaki Y
Combined effect of oxidative stress-related gene polymorphisms on atherosclerosis.
Biochemical and biophysical research communications 2009;379(4):861-5.
2009: Kaneto Hideaki; Matsuoka Taka-aki; Katakami Naoto; Matsuhisa Munehide
Combination of MafA, PDX-1 and NeuroD is a useful tool to efficiently induce insulin-producing surrogate beta-cells.
Current medicinal chemistry 2009;16(24):3144-51.
2008: Miyatsuka Takeshi; Matsuoka Taka-aki; Kaneto Hideaki
Transcription factors as therapeutic targets for diabetes.
Expert opinion on therapeutic targets 2008;12(11):1431-42.
2008: Katakami Naoto; Matsuhisa Munehide; Kaneto Hideaki; Matsuoka Taka-Aki; Sakamoto Ken'ya; Yasuda Tetsuyuki; Yamasaki Yoshimitsu
Endogenous secretory RAGE but not soluble RAGE is associated with carotid atherosclerosis in type 1 diabetes patients.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2008;5(3):190-7.
2008: Kato Ken; Matsuhisa Munehide; Ichimaru Naotsugu; Takahara Shiro; Kojima Yasuyuki; Yamamoto Kaoru; Shiraiwa Toshihiko; Kuroda Akio; Katakami Naoto; Sakamoto Ken'ya; Matsuoka Taka-aki; Kaneto Hideaki; Yamasaki Yoshimitsu; Hori Masatsugu
The impact of new-onset diabetes on arterial stiffness after renal transplantation.
Endocrine journal 2008;55(4):677-83.
2008: Kawashima Satoshi; Kaneto Hideaki; Sakamoto Ken'ya; Yasuda Tetsuyuki; Kuroda Akio; Shiraiwa Toshihiko; Yamamoto Kaoru; Kasami Ryuichi; Matsuoka Taka-aki; Yamasaki Yoshimitsu; Matsuhisa Munehide
Acute progression of severe insulin edema accompanied by pericardial and pleural effusion in a patient with type 2 diabetes.
Diabetes research and clinical practice 2008;81(2):e18-9.
2008: Katakami Naoto; Kaneto Hideaki; Yamasaki Yoshimitsu; Matsuhisa Munehide
Increased serum pigment epithelium-derived factor levels in type 1 diabetic patients with diabetic retinopathy.
Diabetes research and clinical practice 2008;81(1):e4-7.
2008: Yoshiuchi Kazutomi; Matsuhisa Munehide; Katakami Naoto; Nakatani Yoshihisa; Sakamoto Kenya; Matsuoka Takaaki; Umayahara Yutaka; Kosugi Keisuke; Kaneto Hideaki; Yamasaki Yoshimitsu; Hori Masatsugu
Glycated albumin is a better indicator for glucose excursion than glycated hemoglobin in type 1 and type 2 diabetes.
Endocrine journal 2008;55(3):503-7.
2008: Kaneto Hideaki; Miyatsuka Takeshi; Kawamori Dan; Yamamoto Kaoru; Kato Ken; Shiraiwa Toshihiko; Katakami Naoto; Yamasaki Yoshimitsu; Matsuhisa Munehide; Matsuoka Taka-Aki
PDX-1 and MafA play a crucial role in pancreatic beta-cell differentiation and maintenance of mature beta-cell function.
Endocrine journal 2008;55(2):235-52.
2008: Katakami Naoto; Kaneto Hideaki; Matsuhisa Munehide; Umayahara Yutaka; Kosugi Keisuke; Yamasaki Yoshimitsu
Clustering of several cardiovascular risk factors affects tissue characteristics of the carotid artery.
Atherosclerosis 2008;198(1):208-13.
2008: Shimada Kazunori; Ito Toshinori; Tanemura Masahiro; Komoda Hiroshi; Fumimoto Yuichi; Kawamoto Koichi; Nishida Toshirou; Kaneto Hideaki; Sawa Yoshiki
Development of beta-cells in the native pancreas after pancreas allo-transplantation in the Spontaneously Diabetic Torii rat.
The Journal of surgical research 2008;145(2):229-37.
2008: Shimada K; Ito T; Miao G; Tanemura M; Komoda H; Fumimoto Y; Kawamoto K; Nishida T; Kaneto H; Sawa Y
Regeneration of beta cells in the native pancreata after syngeneic and allogeneic pancreas transplantations in spontaneously type 2 diabetic Torii rats.
Transplantation proceedings 2008;40(2):438-40.
2008: Kawashima Satoshi; Kaneto Hideaki; Sakamoto Ken'ya; Honsho Ikuko; Yasuda Tetsuyuki; Kuroda Akio; Shiraiwa Toshihiko; Kasami Ryuichi; Matsuoka Taka-aki; Yamasaki Yoshimitsu; Matsuhisa Munehide
Dramatic improvement of subcutaneous insulin resistance with nafamostat ointment treatment.
Diabetes care 2008;31(3):e11.
2008: Ko Seung-Hyun; Ryu Gyeong Ryul; Kim SeungBum; Ahn Yu-Bae; Yoon Kun-Ho; Kaneto Hideaki; Ha Hunjoo; Kim Yu Seun; Song Ki-Ho
Inducible nitric oxide synthase-nitric oxide plays an important role in acute and severe hypoxic injury to pancreatic beta cells.
Transplantation 2008;85(3):323-30.
2008: Yoshiuchi Kazutomi; Kaneto Hideaki; Matsuoka Taka-Aki; Kohno Kenji; Iwawaki Takao; Nakatani Yoshihisa; Yamasaki Yoshimitsu; Hori Masatsugu; Matsuhisa Munehide
Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice.
Biochemical and biophysical research communications 2008;366(2):545-50.
2008: Kaneto Hideaki; Matsuoka Taka-aki; Miyatsuka Takeshi; Kawamori Dan; Katakami Naoto; Yamasaki Yoshimitsu; Matsuhisa Munehide
PDX-1 functions as a master factor in the pancreas.
Frontiers in bioscience : a journal and virtual library 2008;13():6406-20.
2007: Yasuda Tetsuyuki; Matsuhisa Munehide; Fujiki Noritaka; Sakamoto Fumie; Tsuji Mayumi; Fujisawa Noriko; Kimura Masato; Ishibashi Rieko; Kaneto Hideaki; Yamasaki Yoshimitsu; Watarai Takao; Imano Eiichi
Is central obesity a good predictor of carotid atherosclerosis in Japanese type 2 diabetes with metabolic syndrome?
Endocrine journal 2007;54(5):695-702.
2007: Kaneto Hideaki; Matsuoka Taka-aki; Katakami Naoto; Kawamori Dan; Miyatsuka Takeshi; Yoshiuchi Kazutomi; Yasuda Tetsuyuki; Sakamoto Ken'ya; Yamasaki Yoshimitsu; Matsuhisa Munehide
Oxidative stress and the JNK pathway are involved in the development of type 1 and type 2 diabetes.
Current molecular medicine 2007;7(7):674-86.
2007: Yamamoto Kaoru; Miyatsuka Takeshi; Tanaka Ayako; Toyoda Shuichi; Kato Ken; Shiraiwa Toshihiko; Fujitani Yoshio; Yamasaki Yoshimitsu; Hori Masatsugu; Matsuhisa Munehide; Matsuoka Taka-aki; Kaneto Hideaki
Tissue-specific deletion of c-Jun in the pancreas has limited effects on pancreas formation.
Biochemical and biophysical research communications 2007;363(4):908-14.
2007: Miyatsuka Takeshi; Matsuoka Taka-aki; Shiraiwa Toshihiko; Yamamoto Tsunehiko; Kojima Itaru; Kaneto Hideaki
Ptf1a and RBP-J cooperate in activating Pdx1 gene expression through binding to Area III.
Biochemical and biophysical research communications 2007;362(4):905-9.
2007: Matsuoka Taka-aki; Kaneto Hideaki; Stein Roland; Miyatsuka Takeshi; Kawamori Dan; Henderson Eva; Kojima Itaru; Matsuhisa Munehide; Hori Masatsugu; Yamasaki Yoshimitsu
MafA regulates expression of genes important to islet beta-cell function.
Molecular endocrinology (Baltimore, Md.) 2007;21(11):2764-74.
2007: Shiraiwa Toshihiko; Kaneto Hideaki; Miyatsuka Takeshi; Kato Ken; Yamamoto Kaoru; Kawashima Ayaha; Kajimoto Yoshitaka; Matsuoka Taka-Aki; Matsuhisa Munehide; Yamasaki Yoshimitsu; Fujitani Yoshio
Establishment of a non-invasive mouse reporter model for monitoring in vivo pdx-1 promoter activity.
Biochemical and biophysical research communications 2007;361(3):739-44.
2007: Kaneto Hideaki; Miyatsuka Takeshi; Fujitani Yoshio; Noguchi Hirofumi; Song Ki-Ho; Yoon Kun-Ho; Matsuoka Taka-Aki
Role of PDX-1 and MafA as a potential therapeutic target for diabetes.
Diabetes research and clinical practice 2007;77 Suppl 1():S127-37.
2007: Xu Gang; Kaneto Hideaki; Laybutt D Ross; Duvivier-Kali Valerie F; Trivedi Nitin; Suzuma Kiyoshi; King George L; Weir Gordon C; Bonner-Weir Susan
Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes.
Diabetes 2007;56(6):1551-8.
2007: Taniguchi Cullen M; Aleman José O; Ueki Kohjiro; Luo Ji; Asano Tomoichiro; Kaneto Hideaki; Stephanopoulos Gregory; Cantley Lewis C; Kahn C Ronald
The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
Molecular and cellular biology 2007;27(8):2830-40.
2007: Kaneto Hideaki; Katakami Naoto; Kawamori Dan; Miyatsuka Takeshi; Sakamoto Ken'ya; Matsuoka Taka-Aki; Matsuhisa Munehide; Yamasaki Yoshimitsu
Involvement of oxidative stress in the pathogenesis of diabetes.
Antioxidants & redox signaling 2007;9(3):355-66.
2007: Yatoh Shigeru; Akashi Tomoyuki; Chan Phillip P; Kaneto Hideaki; Sharma Arun; Bonner-Weir Susan; Weir Gordon C
NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes.
Diabetes/metabolism research and reviews 2007;23(3):239-49.
2007: Suzuma Izumi; Murakami Tomoaki; Suzuma Kiyoshi; Kaneto Hideaki; Watanabe Daisuke; Ojima Tomonari; Honda Yoshihito; Takagi Hitoshi; Yoshimura Nagahisa
Cyclic stretch-induced reactive oxygen species generation enhances apoptosis in retinal pericytes through c-jun NH2-terminal kinase activation.
Hypertension 2007;49(2):347-54.
2007: Katakami Naoto; Kaneto Hideaki; Matsuhisa Munehide; Yoshiuchi Kazutomi; Kato Ken; Yamamoto Kaoru; Umayahara Yutaka; Kosugi Keisuke; Hori Masatsugu; Yamasaki Yoshimitsu
Serum interleukin-18 levels are increased and closely associated with various soluble adhesion molecule levels in type 1 diabetic patients.
Diabetes care 2007;30(1):159-61.
2007: Katakami Naoto; Matsuhisa Munehide; Kaneto Hideaki; Yamasaki Yoshimitsu
Serum endogenous secretory RAGE levels are inversely associated with carotid IMT in type 2 diabetic patients.
Atherosclerosis 2007;190(1):22-3.
2007: Kaneto Hideaki; Miyatsuka Takeshi; Kawamori Dan; Matsuoka Taka-Aki
Pleiotropic Roles of PDX-1 in the Pancreas.
The review of diabetic studies : RDS 2007;4(4):209-25.
2007: Kaneto Hideaki; Miyatsuka Takeshi; Shiraiwa Toshihiko; Yamamoto Kaoru; Kato Ken; Fujitani Yoshio; Matsuoka Taka-aki
Crucial role of PDX-1 in pancreas development, beta-cell differentiation, and induction of surrogate beta-cells.
Current medicinal chemistry 2007;14(16):1745-52.
2006: Kaneto Hideaki; Kawamori Dan; Matsuoka Taka-aki
[Insulin resistance in pancreatic beta-cells: possible implication in beta-cell glucose toxicity]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():203-11.
2006: Yamasaki Yoshimitsu; Katakami Naoto; Sakamoto Ken'ya; Kaneto Hideaki; Matsuhisa Munehide; Sato Hiroshi; Hori Masatsugu; Haneda Masakazu; Kashiwagi Atsunori; Tanaka Yasushi; Kawamori Ryuzo; Kuno Shin-Ichi
Combination of multiple genetic risk factors is synergistically associated with carotid atherosclerosis in Japanese subjects with type 2 diabetes.
Diabetes care 2006;29(11):2445-51.
2006: Nakamura Yumiko; Kaneto Hideaki; Miyatsuka Takeshi; Matsuoka Taka-aki; Matsuhisa Munehide; Node Koichi; Hori Masatsugu; Yamasaki Yoshimitsu
Marked increase of insulin gene transcription by suppression of the Rho/Rho-kinase pathway.
Biochemical and biophysical research communications 2006;350(1):68-73.
2006: Amagasaki Kenichi; Kaneto Hideaki; Heldin Carl-Henrik; Lennartsson Johan
c-Jun N-terminal kinase is necessary for platelet-derived growth factor-mediated chemotaxis in primary fibroblasts.
The Journal of biological chemistry 2006;281(31):22173-9.
2006: Katakami N; Kaneto H; Matsuhisa M; Miyatsuka T; Sakamoto K; Kawamori D; Yoshiuchi K; Nakamura Y; Kato K; Yamamoto K; Kosugi K; Hori M; Yamasaki Y
Association of soluble CD40 ligand with carotid atherosclerosis in Japanese type 1 diabetic patients.
Diabetologia 2006;49(7):1670-6.
2006: Xu Gang; Kaneto Hideaki; Lopez-Avalos Maria D; Weir Gordon C; Bonner-Weir Susan
GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts.
Diabetes research and clinical practice 2006;73(1):107-10.
2006: Miyatsuka Takeshi; Kaneto Hideaki; Shiraiwa Toshihiko; Matsuoka Taka-aki; Yamamoto Kaoru; Kato Ken; Nakamura Yumiko; Akira Shizuo; Takeda Kiyoshi; Kajimoto Yoshitaka; Yamasaki Yoshimitsu; Sandgren Eric P; Kawaguchi Yoshiya; Wright Christopher V E; Fujitani Yoshio
Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation.
Genes & development 2006;20(11):1435-40.
2006: Gorogawa S; Iida O; Ikeda M; Watarai T; Kubota M; Nanto S; Kaneto H; Yamasaki Y
Characteristics of peripheral arterial disease in Japanese type 2 diabetic patients.
Diabetologia 2006;49(6):1449-51.
2006: Hazama Yoji; Matsuhisa Munehide; Ohtoshi Kentaro; Gorogawa Shin-Ichi; Kato Ken; Kawamori Dan; Yoshiuchi Kazutomi; Nakamura Yumiko; Shiraiwa Toshihiko; Kaneto Hideaki; Yamasaki Yoshimitsu; Hori Masatsugu
Beneficial effects of nateglinide on insulin resistance in type 2 diabetes.
Diabetes research and clinical practice 2006;71(3):251-5.
2006: Katakami Naoto; Matsuhisa Munehide; Kaneto Hideaki; Yamasaki Yoshimitsu
Endogenous secretory receptor for advanced glycation end product levels are inversely associated with HbA1c in type 2 diabetic patients.
Diabetes care 2006;29(2):469.
2006: Nakatani Y; Kaneto H; Hatazaki M; Yoshiuchi K; Kawamori D; Sakamoto K; Matsuoka T; Ogawa S; Yamasaki Y; Matsuhisa M
Increased stress protein ORP150 autoantibody production in Type 1 diabetic patients.
Diabetic medicine : a journal of the British Diabetic Association 2006;23(2):216-9.
2006: Kawamori Dan; Kaneto Hideaki; Nakatani Yoshihisa; Matsuoka Taka-Aki; Matsuhisa Munehide; Hori Masatsugu; Yamasaki Yoshimitsu
The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation.
The Journal of biological chemistry 2006;281(2):1091-8.
2006: Noguchi Hirofumi; Xu Gang; Matsumoto Shinichi; Kaneto Hideaki; Kobayashi Naoya; Bonner-Weir Susan; Hayashi Shuji
Induction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology.
Cell transplantation 2006;15(10):929-38.
2006: Kaneto Hideaki; Nakatani Yoshihisa; Kawamori Dan; Miyatsuka Takeshi; Matsuoka Taka-aki; Matsuhisa Munehide; Yamasaki Yoshimitsu
Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance.
The international journal of biochemistry & cell biology 2006;38(5-6):782-93.
2005: Katakami Naoto; Sakamoto Ken'ya; Kaneto Hideaki; Matsuhisa Munehide; Hori Masatsugu; Yamasaki Yoshimitsu; Kosugi Keisuke; Waki Hidehiko
Lipid-lowering with atorvastatin improves tissue characteristics of carotid plaque.
Atherosclerosis 2005;183(2):369-71.
2005: Kaneto Hideaki; Kawamori Dan; Matsuoka Taka-aki; Kajimoto Yoshitaka; Yamasaki Yoshimitsu
Oxidative stress and pancreatic beta-cell dysfunction.
American journal of therapeutics 2005;12(6):529-33.
2005: Shiraiwa Toshihiko; Kaneto Hideaki; Miyatsuka Takeshi; Kato Ken; Yamamoto Kaoru; Kawashima Ayaha; Kanda Tsutomu; Suzuki Masaaki; Imano Eiichi; Matsuhisa Munehide; Hori Masatsugu; Yamasaki Yoshimitsu
Postprandial hyperglycemia is a better predictor of the progression of diabetic retinopathy than HbA1c in Japanese type 2 diabetic patients.
Diabetes care 2005;28(11):2806-7.
2005: Katakami Naoto; Matsuhisa Munehide; Kaneto Hideaki; Matsuoka Taka-Aki; Sakamoto Ken'ya; Nakatani Yoshihisa; Ohtoshi Kentaro; Hayaishi-Okano Rieko; Kosugi Keisuke; Hori Masatsugu; Yamasaki Yoshimitsu
Decreased endogenous secretory advanced glycation end product receptor in type 1 diabetic patients: its possible association with diabetic vascular complications.
Diabetes care 2005;28(11):2716-21.
2005: Lee Vivian Y; Schroedl Clara; Brunelle Joslyn K; Buccellato Leonard J; Akinci Ozkan I; Kaneto Hideaki; Snyder Colleen; Eisenbart James; Budinger G R Scott; Chandel Navdeep S
Bleomycin induces alveolar epithelial cell death through JNK-dependent activation of the mitochondrial death pathway.
American journal of physiology. Lung cellular and molecular physiology 2005;289(4):L521-8.
2005: Shiraiwa Toshihiko; Kaneto Hideaki; Miyatsuka Takeshi; Kato Ken; Yamamoto Kaoru; Kawashima Ayaha; Kanda Tsutomu; Suzuki Masaaki; Imano Eiichi; Matsuhisa Munehide; Hori Masatsugu; Yamasaki Yoshimitsu
Post-prandial hyperglycemia is an important predictor of the incidence of diabetic microangiopathy in Japanese type 2 diabetic patients.
Biochemical and biophysical research communications 2005;336(1):339-45.
2005: Hatazaki Masahiro; Matsuhisa Munehide; Nakatani Yoshihisa; Yoshiuchi Kazutomi; Kuroda Akio; Hazama Yoji; Kaneto Hideaki; Yamasaki Yoshimitsu; Hori Masatsugu
Hepatic insulin resistance induced by chronic hindlimb ischemia.
Diabetes research and clinical practice 2005;69(3):209-15.
2005: Murakami Tomoaki; Takagi Hitoshi; Suzuma Kiyoshi; Suzuma Izumi; Ohashi Hirokazu; Watanabe Daisuke; Ojima Tomonari; Suganami Eri; Kurimoto Masafumi; Kaneto Hideaki; Honda Yoshihito; Yoshimura Nagahisa
Angiopoietin-1 attenuates H2O2-induced SEK1/JNK phosphorylation through the phosphatidylinositol 3-kinase/Akt pathway in vascular endothelial cells.
The Journal of biological chemistry 2005;280(36):31841-9.
2005: Kaneto Hideaki; Nakatani Yoshihisa; Kawamori Dan; Miyatsuka Takeshi; Matsuoka Taka-aki; Matsuhisa Munehide; Yamasaki Yoshimitsu
Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance.
The international journal of biochemistry & cell biology 2005;37(8):1595-608.
2005: Gorogawa Shin-Ichi; Kaneto Hideaki; Matsuhisa Munehide; Ohtoshi Kentaro; Kawamori Dan; Hazama Yoji; Yoshiuchi Kazutomi; Yamasaki Yoshimitsu
Possible novel index determined by the glucose clamp test for selection of a suitable therapy for each type 2 diabetic patient.
Diabetes research and clinical practice 2005;69(1):1-4.
2005: Kaneto Hideaki
The JNK pathway as a therapeutic target for diabetes.
Expert opinion on therapeutic targets 2005;9(3):581-92.
2005: Kaneto Hideaki; Matsuoka Taka-Aki; Nakatani Yoshihisa; Kawamori Dan; Miyatsuka Takeshi; Matsuhisa Munehide; Yamasaki Yoshimitsu
Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes.
Journal of molecular medicine (Berlin, Germany) 2005;83(6):429-39.
2005: Ohtoshi Kentaro; Kaneto Hideaki; Node Koichi; Nakamura Yumiko; Shiraiwa Toshihiko; Matsuhisa Munehide; Yamasaki Yoshimitsu
Association of soluble epoxide hydrolase gene polymorphism with insulin resistance in type 2 diabetic patients.
Biochemical and biophysical research communications 2005;331(1):347-50.
2005: Kaneto Hideaki; Nakatani Yoshihisa; Miyatsuka Takeshi; Matsuoka Taka-aki; Matsuhisa Munehide; Hori Masatsugu; Yamasaki Yoshimitsu
PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance.
Diabetes 2005;54(4):1009-22.
2005: Kaneto Hideaki; Matsuoka Taka-aki; Nakatani Yoshihisa; Miyatsuka Takeshi; Matsuhisa Munehide; Hori Masatsugu; Yamasaki Yoshimitsu
A crucial role of MafA as a novel therapeutic target for diabetes.
The Journal of biological chemistry 2005;280(15):15047-52.
2005: Kaneto Hideaki; Matsuoka Taka-aki; Nakatani Yoshihisa; Kawamori Dan; Matsuhisa Munehide; Yamasaki Yoshimitsu
Oxidative stress and the JNK pathway in diabetes.
Current diabetes reviews 2005;1(1):65-72.
2005: Nakatani Yoshihisa; Kaneto Hideaki; Kawamori Dan; Yoshiuchi Kazutomi; Hatazaki Masahiro; Matsuoka Taka-aki; Ozawa Kentaro; Ogawa Satoshi; Hori Masatsugu; Yamasaki Yoshimitsu; Matsuhisa Munehide
Involvement of endoplasmic reticulum stress in insulin resistance and diabetes.
The Journal of biological chemistry 2005;280(1):847-51.
2004: Katakami Naoto; Kaneto Hideaki; Hao Hiroyuki; Umayahara Yutaka; Fujitani Yoshio; Sakamoto Ken'ya; Gorogawa Shin-Ichi; Yasuda Tetsuyuki; Kawamori Dan; Kajimoto Yoshitaka; Matsuhisa Munehide; Yutani Chikao; Hori Masatsugu; Yamasaki Yoshimitsu
Role of pim-1 in smooth muscle cell proliferation.
The Journal of biological chemistry 2004;279(52):54742-9.
2004: Katakami N; Yamasaki Y; Hayaishi-Okano R; Ohtoshi K; Kaneto H; Matsuhisa M; Kosugi K; Hori M
Metformin or gliclazide, rather than glibenclamide, attenuate progression of carotid intima-media thickness in subjects with type 2 diabetes.
Diabetologia 2004;47(11):1906-13.
2004: Kaneto Hideaki; Nakatani Yoshihisa; Miyatsuka Takeshi; Kawamori Dan; Matsuoka Taka-aki; Matsuhisa Munehide; Kajimoto Yoshitaka; Ichijo Hidenori; Yamasaki Yoshimitsu; Hori Masatsugu
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide.
Nature medicine 2004;10(10):1128-32.
2004: Nakatani Yoshihisa; Kaneto Hideaki; Kawamori Dan; Hatazaki Masahiro; Miyatsuka Takeshi; Matsuoka Taka-Aki; Kajimoto Yoshitaka; Matsuhisa Munehide; Yamasaki Yoshimitsu; Hori Masatsugu
Modulation of the JNK pathway in liver affects insulin resistance status.
The Journal of biological chemistry 2004;279(44):45803-9.
2004: Kaneto Hideaki; Kawamori Dan; Nakatani Yoshihisa; Gorogawa Shin-ichi; Matsuoka Taka-aki
Oxidative stress and the JNK pathway as a potential therapeutic target for diabetes.
Drug news & perspectives 2004;17(7):447-53.
2004: Arany Istvan; Megyesi Judit K; Kaneto Hideaki; Price Peter M; Safirstein Robert L
Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells.
American journal of physiology. Renal physiology 2004;287(3):F543-9.
2004: Gorogawa Shin-Ichi; Fujitani Yoshio; Kaneto Hideaki; Hazama Yoji; Watada Hirotaka; Miyamoto Yasuhide; Takeda Kiyoshi; Akira Shizuo; Magnuson Mark A; Yamasaki Yoshimitsu; Kajimoto Yoshitaka; Hori Masatsugu
Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.
Biochemical and biophysical research communications 2004;319(4):1159-70.
2004: Kajimoto Yoshitaka; Kaneto Hideaki
Role of oxidative stress in pancreatic beta-cell dysfunction.
Annals of the New York Academy of Sciences 2004;1011():168-76.
2004: Arany Istvan; Megyesi Judit K; Kaneto Hideaki; Tanaka Sakae; Safirstein Robert L
Activation of ERK or inhibition of JNK ameliorates H(2)O(2) cytotoxicity in mouse renal proximal tubule cells.
Kidney international 2004;65(4):1231-9.
2004: Song Ki-Ho; Ko Seung Hyun; Ahn Yu-Bae; Yoo Soon-Jib; Chin Hyung-Min; Kaneto Hideaki; Yoon Kun-Ho; Cha Bong-Yun; Lee Kwang-Woo; Son Ho-Young
In vitro transdifferentiation of adult pancreatic acinar cells into insulin-expressing cells.
Biochemical and biophysical research communications 2004;316(4):1094-100.
2004: Kaneto Hideaki; Nakatani Yoshihisa; Kawamori Dan; Miyatsuka Takeshi; Matsuoka Taka-aki
Involvement of oxidative stress and the JNK pathway in glucose toxicity.
The review of diabetic studies : RDS 2004;1(4):165-74.
2003: Kawamori Dan; Kajimoto Yoshitaka; Kaneto Hideaki; Umayahara Yutaka; Fujitani Yoshio; Miyatsuka Takeshi; Watada Hirotaka; Leibiger Ingo B; Yamasaki Yoshimitsu; Hori Masatsugu
Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase.
Diabetes 2003;52(12):2896-904.
2003: Miyatsuka T; Kaneto H; Kajimoto Y; Hirota S; Arakawa Y; Fujitani Y; Umayahara Y; Watada H; Yamasaki Y; Magnuson M A; Miyazaki J; Hori M
Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis.
Biochemical and biophysical research communications 2003;310(3):1017-25.
2003: Suzuki Ryo; Tobe Kazuyuki; Terauchi Yasuo; Komeda Kajuro; Kubota Naoto; Eto Kazuhiro; Yamauchi Toshimasa; Azuma Kousuke; Kaneto Hideaki; Taguchi Takashi; Koga Teiichiro; German Michael S; Watada Hirotaka; Kawamori Ryuzo; Wright Christopher V E; Kajimoto Yoshitaka; Kimura Satoshi; Nagai Ryozo; Kadowaki Takashi
Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.
The Journal of biological chemistry 2003;278(44):43691-8.
2003: Noguchi Hirofumi; Kaneto Hideaki; Weir Gordon C; Bonner-Weir Susan
PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells.
Diabetes 2003;52(7):1732-7.
2003: Patané Giovanni; Kaneto Hideaki; Toschi Elena; Sharma Arun; Gupta Sanjeev; Weir Gordon C
Induction of Mad expression leads to augmentation of insulin gene transcription.
Biochemical and biophysical research communications 2003;303(4):1199-208.
2002: Kaneto Hideaki; Xu Gang; Fujii Nobuharu; Kim Shokei; Bonner-Weir Susan; Weir Gordon C
Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression.
The Journal of biological chemistry 2002;277(33):30010-8.
2002: Gorogawa Shin ichi; Kajimoto Yoshitaka; Umayahara Yutaka; Kaneto Hideaki; Watada Hirotaka; Kuroda Akio; Kawamori Dan; Yasuda Tetsuyuki; Matsuhisa Munehide; Yamasaki Yoshimitsu; Hori Masatsugu
Probucol preserves pancreatic beta-cell function through reduction of oxidative stress in type 2 diabetes.
Diabetes research and clinical practice 2002;57(1):1-10.
2002: Laybutt D Ross; Weir Gordon C; Kaneto Hideaki; Lebet Judith; Palmiter Richard D; Sharma Arun; Bonner-Weir Susan
Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes.
Diabetes 2002;51(6):1793-804.
2002: Kaneto Hideaki; Sharma Arun; Suzuma Kiyoshi; Laybutt D Ross; Xu Gang; Bonner-Weir Susan; Weir Gordon C
Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation.
The Journal of biological chemistry 2002;277(15):12998-3006.
2002: Laybutt D Ross; Kaneto Hideaki; Hasenkamp Wendy; Grey Shane; Jonas Jean-Christophe; Sgroi Dennis C; Groff Adam; Ferran Christiane; Bonner-Weir Susan; Sharma Arun; Weir Gordon C
Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia.
Diabetes 2002;51(2):413-23.
2002: Kaneto Hideaki; Suzuma Kiyoshi; Sharma Arun; Bonner-Weir Susan; King George L; Weir Gordon C
Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells.
The Journal of biological chemistry 2002;277(5):3680-5.
2001: Kaneto H; Xu G; Song K H; Suzuma K; Bonner-Weir S; Sharma A; Weir G C
Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress.
The Journal of biological chemistry 2001;276(33):31099-104.
2001: Laybutt R; Hasenkamp W; Groff A; Grey S; Jonas J C; Kaneto H; Sharma A; Bonner-Weir S; Weir G
beta-cell adaptation to hyperglycemia.
Diabetes 2001;50 Suppl 1():S180-1.
2001: Weir G C; Laybutt D R; Kaneto H; Bonner-Weir S; Sharma A
Beta-cell adaptation and decompensation during the progression of diabetes.
Diabetes 2001;50 Suppl 1():S154-9.
2000: Iida M; Ikeda M; Kishimoto M; Tsujino T; Kaneto H; Matsuhisa M; Kajimoto Y; Watarai T; Yamasaki Y; Hori M
Evaluation of gut motility in type II diabetes by the radiopaque marker method.
Journal of gastroenterology and hepatology 2000;15(4):381-5.
2000: Suzuki K; Islam K N; Kaneto H; Ookawara T; Taniguchi N
The contribution of fructose and nitric oxide to oxidative stress in hamster islet tumor (HIT) cells through the inactivation of glutathione peroxidase.
Electrophoresis 2000;21(2):285-8.
1999: Kajimoto Y; Matsuoka T; Kaneto H; Watada H; Fujitani Y; Kishimoto M; Sakamoto K; Matsuhisa M; Kawamori R; Yamasaki Y; Hori M
Induction of glycation suppresses glucokinase gene expression in HIT-T15 cells.
Diabetologia 1999;42(12):1417-24.
1999: Kaneto H; Kajimoto Y; Miyagawa J; Matsuoka T; Fujitani Y; Umayahara Y; Hanafusa T; Matsuzawa Y; Yamasaki Y; Hori M
Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.
Diabetes 1999;48(12):2398-406.
1999: Fujitani Y; Kajimoto Y; Yasuda T; Matsuoka T A; Kaneto H; Umayahara Y; Fujita N; Watada H; Miyazaki J I; Yamasaki Y; Hori M
Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a transcriptional repressor in the pancreas.
Molecular and cellular biology 1999;19(12):8281-91.
1999: Kaneto H; Kajimoto Y; Fujitani Y; Matsuoka T; Sakamoto K; Matsuhisa M; Yamasaki Y; Hori M
Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction.
Diabetologia 1999;42(9):1093-7.
1998: Kaneto H; Ikeda M; Kishimoto M; Iida M; Hoshi A; Watarai T; Kubota M; Kajimoto Y; Yamasaki Y; Hori M
Dramatic recovery of counter-regulatory hormone response to hypoglycaemia after intensive insulin therapy in poorly controlled Type I diabetes mellitus.
Diabetologia 1998;41(8):982-3.
1997: Kaneto H; Yamasaki Y
[Diabetes and apoptosis]
Nippon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():755-8.
1997: Kaneto H; Miyagawa J; Kajimoto Y; Yamamoto K; Watada H; Umayahara Y; Hanafusa T; Matsuzawa Y; Yamasaki Y; Higashiyama S; Taniguchi N
Expression of heparin-binding epidermal growth factor-like growth factor during pancreas development. A potential role of PDX-1 in transcriptional activation.
The Journal of biological chemistry 1997;272(46):29137-43.
1997: Kajimoto Y; Watada H; Matsuoka T a; Kaneto H; Fujitani Y; Miyazaki J; Yamasaki Y
Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells.
The Journal of clinical investigation 1997;100(7):1840-6.
1997: Che W; Asahi M; Takahashi M; Kaneto H; Okado A; Higashiyama S; Taniguchi N
Selective induction of heparin-binding epidermal growth factor-like growth factor by methylglyoxal and 3-deoxyglucosone in rat aortic smooth muscle cells. The involvement of reactive oxygen species formation and a possible implication for atherogenesis in diabetes.
The Journal of biological chemistry 1997;272(29):18453-9.
1997: Matsuoka T; Kajimoto Y; Watada H; Kaneto H; Kishimoto M; Umayahara Y; Fujitani Y; Kamada T; Kawamori R; Yamasaki Y
Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells.
The Journal of clinical investigation 1997;99(1):144-50.
1997: Islam K N; Kayanoki Y; Kaneto H; Suzuki K; Asahi M; Fujii J; Taniguchi N
TGF-beta1 triggers oxidative modifications and enhances apoptosis in HIT cells through accumulation of reactive oxygen species by suppression of catalase and glutathione peroxidase.
Free radical biology & medicine 1997;22(6):1007-17.
1996: Kaneto H; Fujii J; Myint T; Miyazawa N; Islam K N; Kawasaki Y; Suzuki K; Nakamura M; Tatsumi H; Yamasaki Y; Taniguchi N
Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction.
The Biochemical journal 1996;320 ( Pt 3)():855-63.
1996: Watada H; Kajimoto Y; Kaneto H; Matsuoka T; Fujitani Y; Miyazaki J i; Yamasaki Y
Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription.
Biochemical and biophysical research communications 1996;229(3):746-51.
1996: Watada H; Kajimoto Y; Umayahara Y; Matsuoka T; Kaneto H; Fujitani Y; Kamada T; Kawamori R; Yamasaki Y
The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells.
Diabetes 1996;45(11):1478-88.
1996: Hoshi A; Takahashi M; Fujii J; Myint T; Kaneto H; Suzuki K; Yamasaki Y; Kamada T; Taniguchi N
Glycation and inactivation of sorbitol dehydrogenase in normal and diabetic rats.
The Biochemical journal 1996;318 ( Pt 1)():119-23.
1996: Taniguchi N; Kaneto H; Asahi M; Takahashi M; Wenyi C; Higashiyama S; Fujii J; Suzuki K; Kayanoki Y
Involvement of glycation and oxidative stress in diabetic macroangiopathy.
Diabetes 1996;45 Suppl 3():S81-3.
1996: Seo H G; Fujiwara N; Kaneto H; Asahi M; Fujii J; Taniguchi N
Effect of a nitric oxide synthase inhibitor, S-ethylisothiourea, on cultured cells and cardiovascular functions of normal and lipopolysaccharide-treated rabbits.
Journal of biochemistry 1996;119(3):553-8.
1996: Fujii J; Myint T; Okado A; Kaneto H; Taniguchi N
Oxidative stress caused by glycation of Cu,Zn-superoxide dismutase and its effects on intracellular components.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1996;11 Suppl 5():34-40.
1995: Kaneto H; Fujii J; Seo H G; Suzuki K; Matsuoka T; Nakamura M; Tatsumi H; Yamasaki Y; Kamada T; Taniguchi N
Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells.
Diabetes 1995;44(7):733-8.
1995: Taniguchi N; Kaneto H; Islam K N; Hoshi S; Myint T
Glycation of metal-containing proteins such as Cu,Zn-superoxide dismutase, ceruloplasmin, and ferritin: possible implication for DNA damage in vivo.
Contributions to nephrology 1995;112():18-23.
1994: Kaneto H; Fujii J; Suzuki K; Kasai H; Kawamori R; Kamada T; Taniguchi N
DNA cleavage induced by glycation of Cu,Zn-superoxide dismutase.
The Biochemical journal 1994;304 ( Pt 1)():219-25.

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