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Ji-Hye Kang

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Chemicals & Drugs

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Ji-Hye Kang; Yerim Kim; Shin-Hye Won; Song-Kyu Park; Chang Woo Lee; Hwan Mook Kim; Nancy E Lewin; Nicholas A Perry; Larry V Pearce; Daniel J Lundberg; Robert J Surawski; Peter M Blumberg; Jeewoo Lee
Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents.
Ji-Hye Kang; Himanshu Garg; Dina M Sigano; Nicholas Francella; Robert Blumenthal; Victor E Marquez
Ceramides: branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency.
Yongseok Choi; Yongmei Pu; Megan L Peach; Ji-Hye Kang; Nancy E Lewin; Dina M Sigano; Susan H Garfield; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta.

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2010: Ji-Hye Kang; Yerim Kim; Shin-Hye Won; Song-Kyu Park; Chang Woo Lee; Hwan Mook Kim; Nancy E Lewin; Nicholas A Perry; Larry V Pearce; Daniel J Lundberg; Robert J Surawski; Peter M Blumberg; Jeewoo Lee
Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents.
Bioorganic & medicinal chemistry letters 2010;20(3):1008-12.
2009: Ji-Hye Kang; Himanshu Garg; Dina M Sigano; Nicholas Francella; Robert Blumenthal; Victor E Marquez
Ceramides: branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency.
Bioorganic & medicinal chemistry 2009;17(4):1498-505.
2007: Yongseok Choi; Yongmei Pu; Megan L Peach; Ji-Hye Kang; Nancy E Lewin; Dina M Sigano; Susan H Garfield; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta.
Journal of medicinal chemistry 2007;50(15):3465-81.
2006: Ji-Hye Kang; Samira Benzaria; Dina M Sigano; Nancy E Lewin; Yongmei Pu; Megan L Peach; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions.
Journal of medicinal chemistry 2006;49(11):3185-203.
2006: Jeewoo Lee; Ji-Hye Kang; Kee-Chung Han; Yerim Kim; Su Yeon Kim; Hae-Suk Youn; Inhee Mook-Jung; Hee Kim; Jee Hye Lo Han; Hee-Jin Ha; Young Ho Kim; Victor E Marquez; Nancy E Lewin; Larry V Pearce; Daniel J Lundberg; Peter M Blumberg
Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators.
Journal of medicinal chemistry 2006;49(6):2028-36.
2005: Ji-Hye Kang; Megan L Peach; Yongmei Pu; Nancy E Lewin; Marc C Nicklaus; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.
Journal of medicinal chemistry 2005;48(18):5738-48.
2004: Ji-Hye Kang; Maqbool A Siddiqui; Dina M Sigano; Krzysztof Krajewski; Nancy E Lewin; Yongmei Pu; Peter M Blumberg; Jeewoo Lee; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones.
Organic letters 2004;6(14):2413-6.
2004: Jeewoo Lee; Su Yeon Kim; Ji-Hye Kang; Geza Acs; Peter Acs; Peter M Blumberg; Victor E Marquez
Conformationally constrained diacylglycerol (DAG) analogs: 4-C-hydroxyethyl-5-O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone analogs as protein kinase C (PKC) ligands.
European journal of medicinal chemistry 2004;39(1):69-77.
2003: Yongseok Choi; Ji-Hye Kang; Nancy E Lewin; Peter M Blumberg; Jeewoo Lee; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain.
Journal of medicinal chemistry 2003;46(13):2790-3.
2003: Ji-Hye Kang; Hye-Eun Chung; Su Yeon Kim; Yerim Kim; Jeewoo Lee; Nancy E Lewin; Larry V Pearce; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones.
Bioorganic & medicinal chemistry 2003;11(12):2529-39.
2001: Jeewoo Lee; Kee-Chung Han; Ji-Hye Kang; L L Pearce; Nancy E Lewin; S Yan; Samira Benzaria; Marc C Nicklaus; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity.
Journal of medicinal chemistry 2001;44(25):4309-12.
2001: Jeewoo Lee; Kee-Chung Han; S Y Lee; Su Yeon Kim; Ji-Hye Kang; Nancy E Lewin; L S Best; Peter M Blumberg; Victor E Marquez
5-acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a novel template for protein kinase C (PKC) binding.
Farmaco (Società chimica italiana : 1989) 2001;56(3):203-10.
2000: Kassoum Nacro; B Bienfait; Jeewoo Lee; Kee-Chung Han; Ji-Hye Kang; Samira Benzaria; Nancy E Lewin; Dipak Bhattacharyya; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?
Journal of medicinal chemistry 2000;43(5):921-44.
1999: Jeewoo Lee; Ji-Hye Kang; S Y Lee; Kee-Chung Han; C M Torres; Dipak Bhattacharyya; Peter M Blumberg; Victor E Marquez
Protein kinase C ligands based on tetrahydrofuran templates containing a new set of phorbol ester pharmacophores.
Journal of medicinal chemistry 1999;42(20):4129-39.