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James Kang

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Srinivasan Dinesh Kumar; Minqin Ren; Ramar Perumal Samy; Boon-Huat Bay; S Thameem Dheen; Y James Kang; Murugaiyan Vijaya; Frank Watt; Samuel Sam Wah Tay
Zinc supplementation prevents cardiomyocyte apoptosis and congenital heart defects in embryos of diabetic mice.
Jianglong Hou; Y James Kang
Regression of pathological cardiac hypertrophy: signaling pathways and therapeutic targets.
Liying Qiu; Zhen Zhang; Xueqin Ding; Y James Kang
Copper is required for cobalt-induced transcriptional activity of hypoxia-inducible factor-1.

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2012: Srinivasan Dinesh Kumar; Minqin Ren; Ramar Perumal Samy; Boon-Huat Bay; S Thameem Dheen; Y James Kang; Murugaiyan Vijaya; Frank Watt; Samuel Sam Wah Tay
Zinc supplementation prevents cardiomyocyte apoptosis and congenital heart defects in embryos of diabetic mice.
Free radical biology & medicine 2012;53(8):1595-606.
2012: Jianglong Hou; Y James Kang
Regression of pathological cardiac hypertrophy: signaling pathways and therapeutic targets.
Pharmacology & therapeutics 2012;135(3):337-54.
2012: Liying Qiu; Zhen Zhang; Xueqin Ding; Y James Kang
Copper is required for cobalt-induced transcriptional activity of hypoxia-inducible factor-1.
The Journal of pharmacology and experimental therapeutics 2012;342(2):561-7.
2012: Yuping Xie; Pingliang Yang; Jianmin Chen; Pengfei Han; Jianglong Hou; Y James Kang
Immunohistochemical detection of differentially localized up-regulation of lysyl oxidase and down-regulation of matrix metalloproteinase-1 in rhesus monkey model of chronic myocardial infarction.
Experimental biology and medicine (Maywood, N.J.) 2012;237(7):853-9.
2011: Pingliang Yang; Lizhi Zhang; Haibo Song; Huiqi Xie; Yuping Xie; Yonglin Chen; Fabao Gao; Pengfei Han; Jianglong Hou; Y James Kang
Electrocardiographic characterization of rhesus monkey model of ischemic myocardial infarction induced by left anterior descending artery ligation.
Cardiovascular toxicology 2011;11(4):365-72.
2011: Pengfei Han; Haibo Song; Pingliang Yang; Huiqi Xie; Y James Kang
Cardiac arrhythmias induced by chloral hydrate in rhesus monkeys.
Cardiovascular toxicology 2011;11(2):128-33.
2011: Dao-Fu Dai; Simon C Johnson; Jason J Villarin; Michael T Chin; Madeline Nieves-Cintrón; Tony Chen; David J Marcinek; Gerald W Dorn; Y James Kang; Tomas A Prolla; Luis F Santana; Peter S Rabinovitch
Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure.
Circulation research 2011;108(7):837-46.
2011: Xueqin Ding; Huiqi Xie; Y James Kang
The significance of copper chelators in clinical and experimental application.
The Journal of nutritional biochemistry 2011;22(4):301-10.
2011: Y James Kang
Copper and homocysteine in cardiovascular diseases.
Pharmacology & therapeutics 2011;129(3):321-31.
2011: Jing-Zhen Shi; Feng Kang; Qin Wu; Yuan-Fu Lu; Jie Liu; Y James Kang
Nephrotoxicity of mercuric chloride, methylmercury and cinnabar-containing Zhu-Sha-An-Shen-Wan in rats.
Toxicology letters 2011;200(3):194-200.
2010: Xiao Zuo; Huiqi Xie; Daoyin Dong; Nenggang Jiang; Hongming Zhu; Y James Kang
Cytochrome c oxidase is essential for copper-induced regression of cardiomyocyte hypertrophy.
Cardiovascular toxicology 2010;10(3):208-15.
2010: Wei Zhong; Yantao Zhao; Craig J McClain; Y James Kang; Zhanxiang Zhou
Inactivation of hepatocyte nuclear factor-4{alpha} mediates alcohol-induced downregulation of intestinal tight junction proteins.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(3):G643-51.
2010: Xueshan Gao; Mingwei Qian; Jian Li Campian; James Marshall; Zhanxiang Zhou; Andrew M Roberts; Y James Kang; Sumanth D Prabhu; Xiao-Feng Sun; John W Eaton
Mitochondrial dysfunction may explain the cardiomyopathy of chronic iron overload.
Free radical biology & medicine 2010;49(3):401-7.
2010: Steve Lancel; Fuzhong Qin; Shannon L Lennon; Jingmei Zhang; Xiaoyong Tong; Michael J Mazzini; Y James Kang; Deborah A Siwik; Richard A Cohen; Wilson S Colucci
Oxidative posttranslational modifications mediate decreased SERCA activity and myocyte dysfunction in Galphaq-overexpressing mice.
Circulation research 2010;107(2):228-32.
2010: Wanli Xue; Lu Cai; Yi Tan; Patricia Thistlethwaite; Y James Kang; Xiaokun Li; Wenke Feng
Cardiac-specific overexpression of HIF-1{alpha} prevents deterioration of glycolytic pathway and cardiac remodeling in streptozotocin-induced diabetic mice.
The American journal of pathology 2010;177(1):97-105.
2010: Wei Zhong; Craig J McClain; Matthew Cave; Y James Kang; Zhanxiang Zhou
The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction.
American journal of physiology. Gastrointestinal and liver physiology 2010;298(5):G625-33.
2010: Fuzhong Qin; Shannon Lennon-Edwards; Steve Lancel; Andreia Biolo; Deborah A Siwik; David R Pimentel; Gerald W Dorn; Y James Kang; Wilson S Colucci
Cardiac-specific overexpression of catalase identifies hydrogen peroxide-dependent and -independent phases of myocardial remodeling and prevents the progression to overt heart failure in G(alpha)q-overexpressing transgenic mice.
Circulation. Heart failure 2010;3(2):306-13.
2009: Xinqin Kang; Wei Zhong; Jie Liu; Zhenyuan Song; Craig J McClain; Y James Kang; Zhanxiang Zhou
Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha.
Hepatology (Baltimore, Md.) 2009;50(4):1241-50.
2009: Yang Zhou; Katherine Bourcy; Y James Kang
Copper-induced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway.
Cardiovascular research 2009;84(1):54-63.
2009: Tina C Stummann; Mario Beilmann; Göran Duker; Berengere Dumotier; J Magnus Fredriksson; Robin L Jones; Marina Hasiwa; Y James Kang; Carl-Fredrik Mandenius; Thomas Meyer; Giorgio Minotti; Y Jean-Pierre Valentin; Bernd J Zünkler; Susanne Bremer
Report and recommendations of the workshop of the European Centre for the Validation of Alternative Methods for Drug-Induced Cardiotoxicity.
Cardiovascular toxicology 2009;9(3):107-25.
2009: Zhanxiang Zhou; W Thomas Johnson; Y James Kang
Regression of copper-deficient heart hypertrophy: reduction in the size of hypertrophic cardiomyocytes.
The Journal of nutritional biochemistry 2009;20(8):621-8.
2009: Huiqi Xie; Y James Kang
Role of copper in angiogenesis and its medicinal implications.
Current medicinal chemistry 2009;16(10):1304-14.
2008: Y James Kang
Herbogenomics: from traditional Chinese medicine to novel therapeutics.
Experimental biology and medicine (Maywood, N.J.) 2008;233(9):1059-65.
2008: Vishnudutt Purohit; J Christian Bode; Christiane Bode; David A Brenner; Mashkoor A Choudhry; Frank Hamilton; Y James Kang; Ali Keshavarzian; Radhakrishna Rao; Ryan Sartor; Christine Swanson; Jerrold R Turner
Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium.
Alcohol (Fayetteville, N.Y.) 2008;42(5):349-61.
2008: Yang Zhou; Youchun Jiang; Y James Kang
Copper reverses cardiomyocyte hypertrophy through vascular endothelial growth factor-mediated reduction in the cell size.
Journal of molecular and cellular cardiology 2008;45(1):106-17.
2008: Zhanxiang Zhou; Jie Liu; Zhenyuan Song; Craig J McClain; Y James Kang
Zinc supplementation inhibits hepatic apoptosis in mice subjected to a long-term ethanol exposure.
Experimental biology and medicine (Maywood, N.J.) 2008;233(5):540-8.
2008: Xinqin Kang; Zhenyuan Song; Craig J McClain; Y James Kang; Zhanxiang Zhou
Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4alpha in mice subjected to long-term ethanol administration.
The American journal of pathology 2008;172(4):916-25.
2008: William M Hughes; Walter E Rodriguez; Dorothea S Rosenberger; Jing Chen; Utpal Sen; Neetu Tyagi; Karni S Moshal; Thomas Vacek; Y James Kang; Suresh C Tyagi
Role of copper and homocysteine in pressure overload heart failure.
Cardiovascular toxicology 2008;8(3):137-44.
2007: Karni S Moshal; Clacy K Camel; Ganesh K Kartha; Mesia Steed; Neetu Tyagi; Utpal Sen; Y James Kang; David Lominadze; Claudio Maldonado; Suresh C Tyagi
Cardiac dys-synchronization and arrhythmia in hyperhomocysteinemia.
Current neurovascular research 2007;4(4):289-94.
2007: Y James Kang; Youchun Jiang; Jack T Saari
Changes in copper and zinc status and response to dietary copper deficiency in metallothionein-overexpressing transgenic mouse heart.
The Journal of nutritional biochemistry 2007;18(11):714-8.
2007: Michael Lynes; Y James Kang; Stefano L Sensi; George A Perdrizet; Lawrence E Hightower
Heavy metal ions in normal physiology, toxic stress, and cytoprotection.
Annals of the New York Academy of Sciences 2007;1113():159-72.
2007: Wenke Feng; Yuehui Wang; Lu Cai; Y James Kang
Metallothionein rescues hypoxia-inducible factor-1 transcriptional activity in cardiomyocytes under diabetic conditions.
Biochemical and biophysical research communications 2007;360(1):286-9.
2007: Kevyn E Merten; Youchun Jiang; Y James Kang
Zinc inhibits doxorubicin-activated calcineurin signal transduction pathway in H9c2 embryonic rat cardiac cells.
Experimental biology and medicine (Maywood, N.J.) 2007;232(5):682-9.
2007: Zhanxiang Zhou; Xinqin Kang; Youchun Jiang; Zhenyuan Song; Wenke Feng; Craig J McClain; Y James Kang
Preservation of hepatocyte nuclear factor-4alpha is associated with zinc protection against TNF-alpha hepatotoxicity in mice.
Experimental biology and medicine (Maywood, N.J.) 2007;232(5):622-8.
2007: Youchun Jiang; Corey Reynolds; Chang Xiao; Wenke Feng; Zhanxiang Zhou; Walter E Rodriguez; Suresh C Tyagi; John W Eaton; Jack T Saari; Y James Kang
Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice.
The Journal of experimental medicine 2007;204(3):657-66.
2007: Yang Zhou; Youchun Jiang; Y James Kang
Copper inhibition of hydrogen peroxide-induced hypertrophy in embryonic rat cardiac H9c2 cells.
Experimental biology and medicine (Maywood, N.J.) 2007;232(3):385-9.
2007: Y James Kang
Antioxidant defense against anthracycline cardiotoxicity by metallothionein.
Cardiovascular toxicology 2007;7(2):95-100.
2006: Kevyn E Merten; Youchun Jiang; Wenke Feng; Y James Kang
Calcineurin activation is not necessary for Doxorubicin-induced hypertrophy in H9c2 embryonic rat cardiac cells: involvement of the phosphoinositide 3-kinase-Akt pathway.
The Journal of pharmacology and experimental therapeutics 2006;319(2):934-40.
2006: Lu Cai; Yuehui Wang; Guihua Zhou; Teresa Chen; Ye Song; Xiaokun Li; Y James Kang
Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy.
Journal of the American College of Cardiology 2006;48(8):1688-97.
2006: Y James Kang
Metallothionein redox cycle and function.
Experimental biology and medicine (Maywood, N.J.) 2006;231(9):1459-67.
2006: M George Cherian; Y James Kang
Metallothionein and liver cell regeneration.
Experimental biology and medicine (Maywood, N.J.) 2006;231(2):138-44.
2006: Wenke Feng; Frederick Benz; Jian Cai; William M Pierce; Y James Kang
Metallothionein disulfides are present in metallothionein-overexpressing transgenic mouse heart and increase under conditions of oxidative stress.
The Journal of biological chemistry 2006;281(2):681-7.
2006: Y James Kang
Cardiac hypertrophy: a risk factor for QT-prolongation and cardiac sudden death.
Toxicologic pathology 2006;34(1):58-66.
2005: Kevyn E Merten; Wenke Feng; Li Zhang; William Pierce; Jian Cai; Klein Jon; Y James Kang
Modulation of cytochrome C oxidase-va is possibly involved in metallothionein protection from doxorubicin cardiotoxicity.
The Journal of pharmacology and experimental therapeutics 2005;315(3):1314-9.
2005: Yan Li; Lipeng Wang; Dale A Schuschke; Zhanxiang Zhou; Jack T Saari; Y James Kang
Marginal dietary copper restriction induces cardiomyopathy in rats.
The Journal of nutrition 2005;135(9):2130-6.
2005: Y James Kang; Zhanxiang Zhou
Zinc prevention and treatment of alcoholic liver disease.
Molecular aspects of medicine 2005;26(4-5):391-404.
2005: Lipeng Wang; Zhanxiang Zhou; Jack T Saari; Y James Kang
Alcohol-induced myocardial fibrosis in metallothionein-null mice: prevention by zinc supplementation.
The American journal of pathology 2005;167(2):337-44.
2005: Wenke Feng; Jian Cai; William M Pierce; Renty B Franklin; Wolfgang Maret; Frederick Benz; Y James Kang
Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts.
Biochemical and biophysical research communications 2005;332(3):853-8.
2005: Ye Song; Jianxun Wang; Yan Li; Yibo Du; Gavin E Arteel; Jack T Saari; Y James Kang; Lu Cai
Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury.
The American journal of pathology 2005;167(1):17-26.
2005: Zhanxiang Zhou; Lipeng Wang; Zhenyuan Song; Jack T Saari; Craig J McClain; Y James Kang
Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress.
The American journal of pathology 2005;166(6):1681-90.
2005: Lu Cai; Jianxun Wang; Yan Li; Xuihua Sun; Lipeng Wang; Zhanxiang Zhou; Y James Kang
Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy.
Diabetes 2005;54(6):1829-37.
2004: Youchun Jiang; Y James Kang
Metallothionein gene therapy for chemical-induced liver fibrosis in mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(6):1130-9.
2004: Zhenyuan Song; Zhanxiang Zhou; Silvia Uriarte; Lipeng Wang; Y James Kang; Theresa Chen; Shirish Barve; Craig J McClain
S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease.
Hepatology (Baltimore, Md.) 2004;40(4):989-97.
2004: Laila Elsherif; Youchun Jiang; Jack T Saari; Y James Kang
Dietary copper restriction-induced changes in myocardial gene expression and the effect of copper repletion.
Experimental biology and medicine (Maywood, N.J.) 2004;229(7):616-22.
2004: Muralidhar Kannan; Lipeng Wang; Y James Kang
Myocardial oxidative stress and toxicity induced by acute ethanol exposure in mice.
Experimental biology and medicine (Maywood, N.J.) 2004;229(6):553-9.
2004: Jason C Lambert; Zhanxiang Zhou; Lipeng Wang; Zhenyuan Song; Craig J McClain; Y James Kang
Preservation of intestinal structural integrity by zinc is independent of metallothionein in alcohol-intoxicated mice.
The American journal of pathology 2004;164(6):1959-66.
2004: Youchun Jiang; Jie Liu; Michael P Waalkes; Y James Kang
Changes in the gene expression associated with carbon tetrachloride-induced liver fibrosis persist after cessation of dosing in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2004;79(2):404-10.
2004: Zhanxiang Zhou; Lipeng Wang; Zhenyuan Song; Jack T Saari; Craig J McClain; Y James Kang
Abrogation of nuclear factor-kappaB activation is involved in zinc inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha production and liver injury.
The American journal of pathology 2004;164(5):1547-56.
2004: Laila Elsherif; Lipeng Wang; Jack T Saari; Y James Kang
Regression of dietary copper restriction-induced cardiomyopathy by copper repletion in mice.
The Journal of nutrition 2004;134(4):855-60.
2003: Y James Kang; Yan Li; Xichun Sun; Xiuhua Sun
Antiapoptotic effect and inhibition of ischemia/reperfusion-induced myocardial injury in metallothionein-overexpressing transgenic mice.
The American journal of pathology 2003;163(4):1579-86.
2003: Zhanxiang Zhou; Lipeng Wang; Zhenyuan Song; Jason C Lambert; Craig J McClain; Y James Kang
A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production.
The American journal of pathology 2003;163(3):1137-46.
2003: Laila Elsherif; Raymond V Ortines; Jack T Saari; Y James Kang
Congestive heart failure in copper-deficient mice.
Experimental biology and medicine (Maywood, N.J.) 2003;228(7):811-7.
2003: Jason C Lambert; Zhanxiang Zhou; Lipeng Wang; Zhenyuan Song; Craig J McClain; Y James Kang
Prevention of alterations in intestinal permeability is involved in zinc inhibition of acute ethanol-induced liver damage in mice.
The Journal of pharmacology and experimental therapeutics 2003;305(3):880-6.
2003: Jason C Lambert; Zhanxiang Zhou; Y James Kang
Suppression of Fas-mediated signaling pathway is involved in zinc inhibition of ethanol-induced liver apoptosis.
Experimental biology and medicine (Maywood, N.J.) 2003;228(4):406-12.
2003: Yan Li; John M Wo; Lu Cai; Zhanxiang Zhou; David Rosenbaum; Christian Mendez; Mukunda B Ray; Whitney F Jones; Y James Kang
Association of metallothionein expression and lack of apoptosis with progression of carcinogenesis in Barrett's esophagus.
Experimental biology and medicine (Maywood, N.J.) 2003;228(3):286-92.
2003: Ye Song; Zhenyuan Song; Li Zhang; Craig J McClain; Y James Kang; Lu Cai
Diabetes enhances lipopolysaccharide-induced cardiac toxicity in the mouse model.
Cardiovascular toxicology 2003;3(4):363-72.
2003: Lu Cai; Y James Kang
Cell death and diabetic cardiomyopathy.
Cardiovascular toxicology 2003;3(3):219-28.
2003: Y James Kang
New understanding in cardiotoxicity.
Current opinion in drug discovery & development 2003;6(1):110-6.
2002: Xiuhua Sun; Y James Kang
Prior increase in metallothionein levels is required to prevent doxorubicin cardiotoxicity.
Experimental biology and medicine (Maywood, N.J.) 2002;227(8):652-7.
2002: Zhanxiang Zhou; Xiuhua Sun; Jason C Lambert; Jack T Saari; Y James Kang
Metallothionein-independent zinc protection from alcoholic liver injury.
The American journal of pathology 2002;160(6):2267-74.
2002: Lu Cai; Wei Li; Guangwu Wang; Luping Guo; Youchun Jiang; Y James Kang
Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway.
Diabetes 2002;51(6):1938-48.
2002: Changxu Song; Thomas M Vondriska; Guang-Wu Wang; Klein Jon; Xinan Cao; Jun Zhang; Y James Kang; Stanley D'Souza; Peipei Ping
Molecular conformation dictates signaling module formation: example of PKCepsilon and Src tyrosine kinase.
American journal of physiology. Heart and circulatory physiology 2002;282(3):H1166-71.
2002: Klein Jon; Guang-Wu Wang; Zhanxiang Zhou; Abdul Buridi; Y James Kang
Inhibition of tumor necrosis factor-alpha-dependent cardiomyocyte apoptosis by metallothionein.
Cardiovascular toxicology 2002;2(3):209-18.
2002: Y James Kang; Yan Li; Zhanxiang Zhou; Andrew M Roberts; Lu Cai; Myers Steven; Lipeng Wang; Dale A Schuchke
Elevation of serum endothelins and cardiotoxicity induced by particulate matter (PM2.5) in rats with acute myocardial infarction.
Cardiovascular toxicology 2002;2(4):253-61.
2002: Yan Li; Xiuhua Sun; Lipeng Wang; Zhanxiang Zhou; Y James Kang
Myocardial toxicity of arsenic trioxide in a mouse model.
Cardiovascular toxicology 2002;2(1):63-73.
2002: Y James Kang; Xiuhua Sun; Yan Chen; Zhanxiang Zhou
Inhibition of doxorubicin chronic toxicity in catalase-overexpressing transgenic mouse hearts.
Chemical research in toxicology 2002;15(1):1-6.
2001: J C Lambert; Guang-Wu Wang; Y James Kang
Zinc inhibition of caspase-3 activation does not protect HeLa cells from apoptotic cell death.
Toxicology and applied pharmacology 2001;175(1):89-93.
2001: Guang-Wu Wang; Klein Jon; Y James Kang
Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes.
The Journal of pharmacology and experimental therapeutics 2001;298(2):461-8.
2001: Zhanxiang Zhou; Xiuhua Sun; Y James Kang
Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway.
The American journal of pathology 2001;159(1):329-38.
2001: Guang-Wu Wang; Zhanxiang Zhou; Klein Jon; Y James Kang
Inhibition of hypoxia/reoxygenation-induced apoptosis in metallothionein-overexpressing cardiomyocytes.
American journal of physiology. Heart and circulatory physiology 2001;280(5):H2292-9.
2001: Xiuhua Sun; Zhanxiang Zhou; Y James Kang
Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart.
Cancer research 2001;61(8):3382-7.
2001: Lu Cai; Y James Kang
Oxidative stress and diabetic cardiomyopathy: a brief review.
Cardiovascular toxicology 2001;1(3):181-93.
2000: Lu Cai; Klein Jon; Y James Kang
Metallothionein inhibits peroxynitrite-induced DNA and lipoprotein damage.
The Journal of biological chemistry 2000;275(50):38957-60.
2000: Y James Kang; Z X Zhou; Guang-Wu Wang; Abdul Buridi; Klein Jon
Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases.
The Journal of biological chemistry 2000;275(18):13690-8.
2000: Y James Kang; Z X Zhou; H Wu; Guang-Wu Wang; Jack T Saari; Klein Jon
Metallothionein inhibits myocardial apoptosis in copper-deficient mice: role of atrial natriuretic peptide.
Laboratory investigation; a journal of technical methods and pathology 2000;80(5):745-57.
2000: Zhanxiang Zhou; Y James Kang
Immunocytochemical localization of metallothionein and its relation to doxorubicin toxicity in transgenic mouse heart.
The American journal of pathology 2000;156(5):1653-62.
2000: Y James Kang; H Wu; Jack T Saari
Alterations in hypertrophic gene expression by dietary copper restriction in mouse heart.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 2000;223(3):282-7.
1999: Y James Kang
The antioxidant function of metallothionein in the heart.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1999;222(3):263-73.
1999: Y James Kang; G Li; Jack T Saari
Metallothionein inhibits ischemia-reperfusion injury in mouse heart.
The American journal of physiology 1999;276(3 Pt 2):H993-7.
1999: Guang-Wu Wang; Y James Kang
Inhibition of doxorubicin toxicity in cultured neonatal mouse cardiomyocytes with elevated metallothionein levels.
The Journal of pharmacology and experimental therapeutics 1999;288(3):938-44.
1999: Guang-Wu Wang; Dale A Schuschke; Y James Kang
Metallothionein-overexpressing neonatal mouse cardiomyocytes are resistant to H2O2 toxicity.
The American journal of physiology 1999;276(1 Pt 2):H167-75.
1998: H Y Wu; Y James Kang
Inhibition of buthionine sulfoximine-enhanced doxorubicin toxicity in metallothionein overexpressing transgenic mouse heart.
The Journal of pharmacology and experimental therapeutics 1998;287(2):515-20.
1998: X Yin; H Wu; Y Chen; Y James Kang
Induction of antioxidants by adriamycin in mouse heart.
Biochemical pharmacology 1998;56(1):87-93.
1997: Y Chen; A Yu; Jack T Saari; Y James Kang
Repression of hypoxia-reoxygenation injury in the catalase-overexpressing heart of transgenic mice.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1997;216(1):112-6.
1997: Y James Kang; Y Chen; A Yu; M Voss-McCowan; Paul N Epstein
Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity.
The Journal of clinical investigation 1997;100(6):1501-6.
1997: G Li; Y Chen; Jack T Saari; Y James Kang
Catalase-overexpressing transgenic mouse heart is resistant to ischemia-reperfusion injury.
The American journal of physiology 1997;273(3 Pt 2):H1090-5.
1997: Emiko Lynn Kreklau; J M Alexander; Y James Kang
Decreased sensitivity to adriamycin in cadmium-resistant human lung carcinoma A549 cells.
Biochemical pharmacology 1997;53(5):747-54.
1996: Y James Kang; Y Chen; Paul N Epstein
Suppression of doxorubicin cardiotoxicity by overexpression of catalase in the heart of transgenic mice.
The Journal of biological chemistry 1996;271(21):12610-6.
1996: Y James Kang; E O Uthus
Suppression of plasma estradiol and progesterone concentrations by buthionine sulfoximine in female rats.
Biochemical pharmacology 1996;51(4):567-70.
1996: Y James Kang; J M Alexander
Alterations of the glutathione redox cycle status in fumonisin B1-treated pig kidney cells.
Journal of biochemical toxicology 1996;11(3):121-6.
1995: Emiko Lynn Kreklau; Y Chen; Y James Kang
Cadmium resistance in A549 cells correlates with elevated glutathione content but not antioxidant enzymatic activities.
Free radical biology & medicine 1995;19(6):805-12.
1995: Y Chen; Jack T Saari; Y James Kang
Expression of gamma-glutamylcysteine synthetase in the liver of copper-deficient rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1995;210(2):102-6.
1995: Y James Kang
Buthionine sulfoximine enhances glutathione-but attenuates glutamate-stimulated cell proliferation.
Cellular & molecular biology research 1995;41(2):131-6.
1994: Y James Kang; Y Feng; Emiko Lynn Kreklau
Glutathione stimulates A549 cell proliferation in glutamine-deficient culture: the effect of glutamate supplementation.
Journal of cellular physiology 1994;161(3):589-96.
1994: Y Chen; Jack T Saari; Y James Kang
Weak antioxidant defenses make the heart a target for damage in copper-deficient rats.
Free radical biology & medicine 1994;17(6):529-36.
1994: Y James Kang
Exogenous glutathione attenuates the antiproliferative effect of buthionine sulfoximine.
Toxicology 1994;88(1-3):177-89.
1993: Y James Kang
Buthionine sulfoximine spares intracellular glutamate: a possible mechanism for cell growth stimulation.
Cellular & molecular biology research 1993;39(7):675-84.