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Kenji Kangawa

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Kyoraku Itaru; Shiomi Kazutaka; Kangawa Kenji; Nakazato Masamitsu
Ghrelin reverses experimental diabetic neuropathy in mice.
Tokudome Takeshi; Kishimoto Ichiro; Yamahara Kenichi; Osaki Tsukasa; Minamino Naoto; Horio Takeshi; Sawai Kazutomo; Kawano Yuhei; Miyazato Mikiya; Sata Masataka; Kohno Masakazu; Nakao Kazuwa; Kangawa Kenji
Impaired recovery of blood flow after hind-limb ischemia in mice lacking guanylyl cyclase-A, a receptor for atrial and brain natriuretic peptides.
Iwakura Hiroshi; Ariyasu Hiroyuki; Li Yushu; Kanamoto Naotetsu; Bando Mika; Yamada Go; Hosoda Hiroshi; Hosoda Kiminori; Shimatsu Akira; Nakao Kazuwa; Kangawa Kenji; Akamizu Takashi
A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance.

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All Publications

2009: Kyoraku Itaru; Shiomi Kazutaka; Kangawa Kenji; Nakazato Masamitsu
Ghrelin reverses experimental diabetic neuropathy in mice.
Biochemical and biophysical research communications 2009;389(3):405-8.
2009: Tokudome Takeshi; Kishimoto Ichiro; Yamahara Kenichi; Osaki Tsukasa; Minamino Naoto; Horio Takeshi; Sawai Kazutomo; Kawano Yuhei; Miyazato Mikiya; Sata Masataka; Kohno Masakazu; Nakao Kazuwa; Kangawa Kenji
Impaired recovery of blood flow after hind-limb ischemia in mice lacking guanylyl cyclase-A, a receptor for atrial and brain natriuretic peptides.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(10):1516-21.
2009: Iwakura Hiroshi; Ariyasu Hiroyuki; Li Yushu; Kanamoto Naotetsu; Bando Mika; Yamada Go; Hosoda Hiroshi; Hosoda Kiminori; Shimatsu Akira; Nakao Kazuwa; Kangawa Kenji; Akamizu Takashi
A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance.
American journal of physiology. Endocrinology and metabolism 2009;297(3):E802-11.
2009: Kaiya Hiroyuki; Furuse Mitsuhiro; Miyazato Mikiya; Kangawa Kenji
Current knowledge of the roles of ghrelin in regulating food intake and energy balance in birds.
General and comparative endocrinology 2009;163(1-2):33-8.
2009: Theil Michael-Mark; Miyake Sachiko; Mizuno Miho; Tomi Chiharu; Croxford J Ludovic; Hosoda Hiroshi; Theil Julia; von Hörsten Stephan; Yokote Hiroaki; Chiba Asako; Lin Youwei; Oki Shinji; Akamizu Takashi; Kangawa Kenji; Yamamura Takashi
Suppression of experimental autoimmune encephalomyelitis by ghrelin.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2859-66.
2009: Hiejima Hiroshi; Nishi Yoshihiro; Hosoda Hiroshi; Yoh Junko; Mifune Hiroharu; Satou Motoyasu; Sugimoto Hiroyuki; Chiba Seiichi; Kawahara Yukie; Tanaka Eiichiro; Yoshimatsu Hironobu; Uchimura Naohisa; Kangawa Kenji; Kojima Masayasu
Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents.
Regulatory peptides 2009;156(1-3):47-56.
2009: Kaiya Hiroyuki; Mori Tsukasa; Miyazato Mikiya; Kangawa Kenji
Ghrelin receptor (GHS-R)-like receptor and its genomic organisation in rainbow trout, Oncorhynchus mykiss.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2009;153(4):438-50.
2009: Schwenke Daryl O; Pearson James T; Shimochi Akito; Kangawa Kenji; Tsuchimochi Hirotsugu; Umetani Keiji; Shirai Mikiyasu; Cragg Patricia A
Changes in pulmonary blood flow distribution in monocrotaline compared with hypoxia-induced models of pulmonary hypertension: assessed using synchrotron radiation.
Journal of hypertension 2009;27(7):1410-9.
2009: Takahashi H; Kurose Y; Suzuki Y; Kojima M; Yamaguchi T; Yoshida Y; Ogino M; Hodate K; Azuma Y; Sugino T; Kojima M; Kangawa K; Hasegawa Y; Kobayashi S
Ghrelin differentially modulates the GH secretory response to GHRH between the fed and fasted states in sheep.
Domestic animal endocrinology 2009;37(1):55-60.
2009: Harada-Shiba Mariko; Takamisawa Itaru; Miyata Kanjiro; Ishii Takehiko; Nishiyama Nobuhiro; Itaka Keiji; Kangawa Kenji; Yoshihara Fumiki; Asada Yujiro; Hatakeyama Kinta; Nagaya Noriya; Kataoka Kazunori
Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(7):1180-6.
2009: Yano Yuichiro; Toshinai Koji; Inokuchi Takashi; Kangawa Kenji; Shimada Kazuyuki; Kario Kazuomi; Nakazato Masamitsu
Plasma des-acyl ghrelin, but not plasma HMW adiponectin, is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensive patients.
Atherosclerosis 2009;204(2):590-4.
2009: Kaiya Hiroyuki; Riley Larry G; Janzen Whitney; Hirano Tetsuya; Grau E Gordon; Miyazato Mikiya; Kangawa Kenji
Identification and genomic sequence of a ghrelin receptor (GHS-R)-like receptor in the Mozambique tilapia, Oreochromis mossambicus.
Zoological science 2009;26(5):330-7.
2009: Nishikimi Toshio; Karasawa Tsuyoshi; Inaba Chikako; Ishimura Kimihiko; Tadokoro Kazuyoshi; Koshikawa Shogo; Yoshihara Fumiki; Nagaya Noritoshi; Sakio Hideaki; Kangawa Kenji; Matsuoka Hiroaki
Effects of long-term intravenous administration of adrenomedullin (AM) plus hANP therapy in acute decompensated heart failure: a pilot study.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(5):892-8.
2009: Miura Tohru; Maruyama Keisuke; Kaiya Hiroyuki; Miyazato Mikiya; Kangawa Kenji; Uchiyama Minoru; Shioda Seiji; Matsuda Kouhei
Purification and properties of ghrelin from the intestine of the goldfish, Carassius auratus.
Peptides 2009;30(4):758-65.
2009: Yamahara K; Min K D; Tomoike H; Kangawa K; Kitamura S; Nagaya N
Pathological role of angiostatin in heart failure: an endogenous inhibitor of mesenchymal stem-cell activation.
Heart (British Cardiac Society) 2009;95(4):283-9.
2009: Masumiya Haruko; Asaumi Yasuhide; Nishi Miyuki; Minamisawa Susumu; Adachi-Akahane Satomi; Yoshida Morikatsu; Kangawa Kenji; Ito Kenta; Kagaya Yutaka; Yanagisawa Teruyuki; Yamazaki Tetsuo; Ma Jianjie; Takeshima Hiroshi
Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes.
Channels (Austin, Tex.) 2009;3(1):6-11.
2008: Iwasaki Eisuke; Suzuki Hidekazu; Sugino Yoshinori; Iida Tsutomu; Nishizawa Toshihiro; Masaoka Tatsuhiro; Hosoda Hiroshi; Kangawa Kenji; Hibi Toshifumi
Decreased levels of adiponectin in obese patients with gastroesophageal reflux evaluated by videoesophagography: possible relationship between gastroesophageal reflux and metabolic syndrome.
Journal of gastroenterology and hepatology 2008;23 Suppl 2():S216-21.
2008: Iwakura Hiroshi; Ariyasu Hiroyuki; Kanamoto Naotetsu; Hosoda Kiminori; Nakao Kazuwa; Kangawa Kenji; Akamizu Takashi
Establishment of a novel neuroblastoma mouse model.
International journal of oncology 2008;33(6):1195-9.
2008: Jin Donghao; Harada Kazuhiko; Ohnishi Shunsuke; Yamahara Kenich; Kangawa Kenji; Nagaya Noritoshi
Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema.
Cardiovascular research 2008;80(3):339-45.
2008: Takahashi Ken-ichi; Chin Kazuo; Akamizu Takashi; Morita Satoshi; Sumi Kensuke; Oga Toru; Matsumoto Hisako; Niimi Akio; Tsuboi Tomomasa; Fukuhara Shunichi; Kangawa Kenji; Mishima Michiaki
Acylated ghrelin level in patients with OSA before and after nasal CPAP treatment.
Respirology (Carlton, Vic.) 2008;13(6):810-6.
2008: Kishimoto I; Tokudome T; Horio T; Soeki T; Chusho H; Nakao K; Kangawa K
C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurones.
Journal of neuroendocrinology 2008;20(11):1213-23.
2008: Sakamoto Takumi; Mori Kenji; Miyazato Mikiya; Kangawa Kenji; Sameshima Hiroshi; Nakahara Keiko; Murakami Noboru
Involvement of neuromedin S in the oxytocin release response to suckling stimulus.
Biochemical and biophysical research communications 2008;375(1):49-53.
2008: Schwenke Daryl O; Tokudome Takeshi; Kishimoto Ichiro; Horio Takeshi; Shirai Mikiyasu; Cragg Patricia A; Kangawa Kenji
Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality.
Endocrinology 2008;149(10):5172-6.
2008: Kodama Tsuyoshi; Ashitani Jun-Ichi; Matsumoto Nobuhiro; Kangawa Kenji; Nakazato Masamitsu
Ghrelin treatment suppresses neutrophil-dominant inflammation in airways of patients with chronic respiratory infection.
Pulmonary pharmacology & therapeutics 2008;21(5):774-9.
2008: Fukumoto Kaori; Nakahara Keiko; Katayama Tetsuro; Miyazatao Mikiya; Kangawa Kenji; Murakami Noboru
Synergistic action of gastrin and ghrelin on gastric acid secretion in rats.
Biochemical and biophysical research communications 2008;374(1):60-3.
2008: Tanaka Kazuhide; Morinobu Shigeru; Ichimura Mai; Asakawa Akihiro; Inui Akio; Hosoda Hiroshi; Kangawa Kenji; Yamawaki Shigeto
Decreased levels of ghrelin, cortisol, and fasting blood sugar, but not n-octanoylated ghrelin, in Japanese schizophrenic inpatients treated with olanzapine.
Progress in neuro-psychopharmacology & biological psychiatry 2008;32(6):1527-32.
2008: Ariyasu Hiroyuki; Iwakura Hiroshi; Yamada Go; Nakao Kazuwa; Kangawa Kenji; Akamizu Takashi
Efficacy of ghrelin as a therapeutic approach for age-related physiological changes.
Endocrinology 2008;149(7):3722-8.
2008: Tokudome Takeshi; Kishimoto Ichiro; Horio Takeshi; Arai Yuji; Schwenke Daryl O; Hino Jun; Okano Ichiro; Kawano Yuhei; Kohno Masakazu; Miyazato Mikiya; Nakao Kazuwa; Kangawa Kenji
Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart.
Circulation 2008;117(18):2329-39.
2008: Akamizu Takashi; Iwakura Hiroshi; Ariyasu Hiroyuki; Hosoda Hiroshi; Murayama Toshinori; Yokode Masayuki; Teramukai Satoshi; Seno Hiroshi; Chiba Tsutomu; Noma Shunichi; Nakai Yoshikatsu; Fukunaga Mikihiko; Nakai Yoshihide; Kangawa Kenji; FD Clinical Study Team
Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite.
European journal of endocrinology / European Federation of Endocrine Societies 2008;158(4):491-8.
2008: Nishida Hidenori; Horio Takeshi; Suzuki Yoshihiko; Iwashima Yoshio; Kamide Kei; Kangawa Kenji; Kawano Yuhei
Plasma adrenomedullin as an independent predictor of future cardiovascular events in high-risk patients: comparison with C-reactive protein and adiponectin.
Peptides 2008;29(4):599-605.
2008: Zhao Zheng; Sakata Ichiro; Okubo Yusuke; Koike Kanako; Kangawa Kenji; Sakai Takafumi
Gastric leptin, but not estrogen and somatostatin, contributes to the elevation of ghrelin mRNA expression level in fasted rats.
The Journal of endocrinology 2008;196(3):529-38.
2008: Piao H; Hosoda H; Kangawa K; Murata T; Narita K; Higuchi T
Ghrelin stimulates milk intake by affecting adult type feeding behaviour in postnatal rats.
Journal of neuroendocrinology 2008;20(3):330-4.
2008: Kaiya Hiroyuki; Miyazato Mikiya; Kangawa Kenji; Peter Richard E; Unniappan Suraj
Ghrelin: a multifunctional hormone in non-mammalian vertebrates.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2008;149(2):109-28.
2008: Hosoda Hiroshi; Kangawa Kenji
The autonomic nervous system regulates gastric ghrelin secretion in rats.
Regulatory peptides 2008;146(1-3):12-8.
2008: Usami Satoru; Kishimoto Ichiro; Saito Yoshihiko; Harada Masaki; Kuwahara Koichiro; Nakagawa Yasuaki; Nakanishi Michio; Yasuno Shinji; Kangawa Kenji; Nakao Kazuwa
Association of CT dinucleotide repeat polymorphism in the 5'-flanking region of the guanylyl cyclase (GC)-A gene with essential hypertension in the Japanese.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(1):89-96.
2008: Ichikawa-Shindo Yuka; Sakurai Takayuki; Kamiyoshi Akiko; Kawate Hisaka; Iinuma Nobuyoshi; Yoshizawa Takahiro; Koyama Teruhide; Fukuchi Junichi; Iimuro Satoshi; Moriyama Nobuo; Kawakami Hayato; Murata Toshinori; Kangawa Kenji; Nagai Ryozo; Shindo Takayuki
The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity.
The Journal of clinical investigation 2008;118(1):29-39.
2008: Soeki Takeshi; Kishimoto Ichiro; Schwenke Daryl O; Tokudome Takeshi; Horio Takeshi; Yoshida Morikatsu; Hosoda Hiroshi; Kangawa Kenji
Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2008;294(1):H426-32.
2008: Obata Hiroaki; Sakai Yoshiki; Ohnishi Shunsuke; Takeshita Satoshi; Mori Hidezo; Kodama Makoto; Kangawa Kenji; Aizawa Yoshifusa; Nagaya Noritoshi
Single injection of a sustained-release prostacyclin analog improves pulmonary hypertension in rats.
American journal of respiratory and critical care medicine 2008;177(2):195-201.
2008: Schwenke Daryl O; Pearson James T; Kangawa Kenji; Umetani Keiji; Shirai Mikiyasu
Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia: assessed using synchrotron radiation microangiography.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;104(1):88-96.
2008: Hori Yasunori; Kageyama Haruaki; Guan Jian-Lian; Kohno Daisuke; Yada Toshihiko; Takenoya Fumiko; Nonaka Naoko; Kangawa Kenji; Shioda Seiji; Yoshida Takemi
Synaptic interaction between ghrelin- and ghrelin-containing neurons in the rat hypothalamus.
Regulatory peptides 2008;145(1-3):122-7.
2008: Schwenke Daryl O; Tokudome Takeshi; Shirai Mikiyasu; Hosoda Hiroshi; Horio Takeshi; Kishimoto Ichiro; Kangawa Kenji
Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats.
Endocrinology 2008;149(1):237-44.
2008: Sato Takahiro; Kurokawa Mamoru; Nakashima Yoshiki; Ida Takanori; Takahashi Tomoko; Fukue Yoshihiko; Ikawa Masahito; Okabe Masaru; Kangawa Kenji; Kojima Masayasu
Ghrelin deficiency does not influence feeding performance.
Regulatory peptides 2008;145(1-3):7-11.
2008: Miyazato Mikiya; Mori Kenji; Ida Takanori; Kojima Masayasu; Murakami Noboru; Kangawa Kenji
Identification and functional analysis of a novel ligand for G protein-coupled receptor, Neuromedin S.
Regulatory peptides 2008;145(1-3):37-41.
2008: Yokokawa Milki; Ohnishi Shunsuke; Ishibashi-Ueda Hatsue; Obata Hiroaki; Otani Kentaro; Miyahara Yoshinori; Tanaka Koichi; Shimizu Wataru; Nakazawa Kazuo; Kangawa Kenji; Kamakura Shiro; Kitamura Soichiro; Nagaya Noritoshi
Transplantation of mesenchymal stem cells improves atrioventricular conduction in a rat model of complete atrioventricular block.
Cell transplantation 2008;17(10-11):1145-55.
2008: Inaoka Yoshihiko; Yazawa Takashi; Mizutani Tetsuya; Kokame Koichi; Kangawa Kenji; Uesaka Miki; Umezawa Akihiro; Miyamoto Kaoru
Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production.
Reproductive biology and endocrinology : RB&E 2008;6():62.
2008: Mori Kenji; Miyazato Mikiya; Kangawa Kenji
Neuromedin S: discovery and functions.
Results and problems in cell differentiation 2008;46():201-12.
2008: Kojima Masayasu; Kangawa Kenji
Structure and function of ghrelin.
Results and problems in cell differentiation 2008;46():89-115.
2007: Pearson James T; Shirai Mikiyasu; Tsuchimochi Hirotsugu; Schwenke Daryl O; Ishida Takayuki; Kangawa Kenji; Suga Hiroyuki; Yagi Naoto
Effects of sustained length-dependent activation on in situ cross-bridge dynamics in rat hearts.
Biophysical journal 2007;93(12):4319-29.
2007: Sato Shingo; Hanada Reiko; Kimura Ayako; Abe Tomomi; Matsumoto Takahiro; Iwasaki Makiko; Inose Hiroyuki; Ida Takanori; Mieda Michihiro; Takeuchi Yasuhiro; Fukumoto Seiji; Fujita Toshiro; Kato Shigeaki; Kangawa Kenji; Kojima Masayasu; Shinomiya Ken-ichi; Takeda Shu
Central control of bone remodeling by neuromedin U.
Nature medicine 2007;13(10):1234-40.
2007: Sawai Kazutomo; Mukoyama Masashi; Mori Kiyoshi; Kasahara Masato; Koshikawa Masao; Yokoi Hideki; Yoshioka Tetsuro; Ogawa Yoshihisa; Sugawara Akira; Nishiyama Hiroyuki; Yamada Shigehito; Kuwahara Takashi; Saleem Moin A; Shiota Kohei; Ogawa Osamu; Miyazato Mikiya; Kangawa Kenji; Nakao Kazuwa
Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney.
American journal of physiology. Renal physiology 2007;293(4):F1363-72.
2007: Yanagawa Bobby; Kataoka Masaharu; Ohnishi Shunsuke; Kodama Makoto; Tanaka Koichi; Miyahara Yoshinori; Ishibashi-Ueda Hatsue; Aizawa Yoshifusa; Kangawa Kenji; Nagaya Noritoshi
Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema.
Cardiovascular research 2007;76(1):110-8.
2007: Kojima Masayasu; Kangawa Kenji
[Structure and function of ghrelin]
Seikagaku. The Journal of Japanese Biochemical Society 2007;79(9):853-67.
2007: Arakawa Mamoru; Suzuki Hidekazu; Minegishi Yuriko; Fukushima Yasushi; Masaoka Tatsuhiro; Ishikawa Takashi; Hosoda Hiroshi; Kangawa Kenji; Hibi Toshifumi
Enhanced ghrelin expression and subsequent acid secretion in mice with genetic H(2)-receptor knockout.
Journal of gastroenterology 2007;42(9):711-8.
2007: Takahashi Hideyuki; Kurose Yohei; Sakaida Muneyuki; Suzuki Yoshihiro; Kobayashi Shigeki; Sugino Toshihisa; Kojima Masayasu; Kangawa Kenji; Hasegawa Yoshihisa; Terashima Yoshiaki
Ghrelin differentially modulates glucose-induced insulin secretion according to feeding status in sheep.
The Journal of endocrinology 2007;194(3):621-5.
2007: Sakamoto Takumi; Mori Kenji; Nakahara Keiko; Miyazato Mikiya; Kangawa Kenji; Sameshima Hiroshi; Murakami Noboru
Neuromedin S exerts an antidiuretic action in rats.
Biochemical and biophysical research communications 2007;361(2):457-61.
2007: Iwakura Hiroshi; Akamizu Takashi; Ariyasu Hiroyuki; Irako Taiga; Hosoda Kiminori; Nakao Kazuwa; Kangawa Kenji
Effects of ghrelin administration on decreased growth hormone status in obese animals.
American journal of physiology. Endocrinology and metabolism 2007;293(3):E819-25.
2007: Murashita Mari; Kusumi Ichiro; Hosoda Hiroshi; Kangawa Kenji; Koyama Tsukasa
Acute administration of clozapine concurrently increases blood glucose and circulating plasma ghrelin levels in rats.
Psychoneuroendocrinology 2007;32(7):777-84.
2007: Itoh Takefumi; Obata Hiroaki; Murakami Shinsuke; Hamada Kaoru; Kangawa Kenji; Kimura Hiroshi; Nagaya Noritoshi
Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats.
American journal of physiology. Lung cellular and molecular physiology 2007;293(2):L446-52.
2007: Yoshihara Fumiki; Ernst Andrea; Morgenthaler Nils G; Horio Takeshi; Nakamura Satoko; Nakahama Hajime; Nakata Hiroto; Bergmann Andreas; Kangawa Kenji; Kawano Yuhei
Midregional proadrenomedullin reflects cardiac dysfunction in haemodialysis patients with cardiovascular disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22(8):2263-8.
2007: Sato Miho; Nakahara Keiko; Miyazato Mikiya; Kangawa Kenji; Murakami Noboru
Regulation of GH secretagogue receptor gene expression in the rat nodose ganglion.
The Journal of endocrinology 2007;194(1):41-6.
2007: Kawamata Takakazu; Inui Akio; Hosoda Hiroshi; Kangawa Kenji; Hori Tomokatsu
Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH.
Clinical endocrinology 2007;67(1):140-4.
2007: Ushiyama Mina; Ikeda Ryuji; Sugawara Hideki; Yoshida Morikatsu; Mori Kenji; Kangawa Kenji; Inoue Kazuhiko; Yamada Katsushi; Miyata Atsuro
Differential intracellular signaling through PAC1 isoforms as a result of alternative splicing in the first extracellular domain and the third intracellular loop.
Molecular pharmacology 2007;72(1):103-11.
2007: Miura Tohru; Maruyama Keisuke; Shimakura Sei-Ichi; Kaiya Hiroyuki; Uchiyama Minoru; Kangawa Kenji; Shioda Seiji; Matsuda Kouhei
Regulation of food intake in the goldfish by interaction between ghrelin and orexin.
Peptides 2007;28(6):1207-13.
2007: Katayama Tetsuro; Shimamoto Shohei; Oda Hideyuki; Nakahara Keiko; Kangawa Kenji; Murakami Noboru
Glucagon receptor expression and glucagon stimulation of ghrelin secretion in rat stomach.
Biochemical and biophysical research communications 2007;357(4):865-70.
2007: Watanabe Ken; Nishikimi Toshio; Takamuro Motoki; Yasuda Kenji; Ishikawa Yuichi; Tanabe Saori; Yamada Osamu; Yagihara Toshikatsu; Suga Shinichi; Kangawa Kenji; Matsuoka Hiroaki; Echigo Shigeyuki
Possible role of adrenomedullin in the regulation of Fontan circulation: mature form of plasma adrenomedullin is extracted in the lung in patients with Fontan procedure.
Regulatory peptides 2007;141(1-3):129-34.
2007: Yamaguchi Yasuhiro; Nagase Takahide; Tomita Tetsuji; Nakamura Kyoko; Fukuhara Shigetomo; Amano Tomokazu; Yamamoto Hiroshi; Ide Yukie; Suzuki Misao; Teramoto Shinji; Asano Tomoichiro; Kangawa Kenji; Nakagata Naomi; Ouchi Yasuyoshi; Kurihara Hiroki
Beta-defensin overexpression induces progressive muscle degeneration in mice.
American journal of physiology. Cell physiology 2007;292(6):C2141-9.
2007: Akamizu Takashi; Kangawa Kenji
Emerging results of anticatabolic therapy with ghrelin.
Current opinion in clinical nutrition and metabolic care 2007;10(3):278-83.
2007: Kawakoshi Akatsuki; Kaiya Hiroyuki; Riley Larry G; Hirano Tetsuya; Grau E Gordon; Miyazato Mikiya; Hosoda Hiroshi; Kangawa Kenji
Identification of a ghrelin-like peptide in two species of shark, Sphyrna lewini and Carcharhinus melanopterus.
General and comparative endocrinology 2007;151(3):259-68.
2007: Kaiya Hiroyuki; Saito Ei-Suke; Tachibana Tetsuya; Furuse Mitsuhiro; Kangawa Kenji
Changes in ghrelin levels of plasma and proventriculus and ghrelin mRNA of proventriculus in fasted and refed layer chicks.
Domestic animal endocrinology 2007;32(4):247-59.
2007: Ohnishi Shunsuke; Nagaya Noritoshi; Kangawa Kenji
[Ghrelin]
Nippon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 4():186-90.
2007: Tokudome Takeshi; Kishimoto Ichiro; Horio Takeshi; Kangawa Kenji
[Cardioprotective effects of natriuretic peptides]
Nippon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 4():165-9.
2007: Obata Hiroaki; Yanagawa Bobby; Tanaka Koichi; Ohnishi Shunsuke; Kataoka Masaharu; Miyahara Yoshinori; Ishibashi-Ueda Hatsue; Kodama Makoto; Aizawa Yoshifusa; Kangawa Kenji; Nagaya Noritoshi
CNP infusion attenuates cardiac dysfunction and inflammation in myocarditis.
Biochemical and biophysical research communications 2007;356(1):60-6.
2007: Pearson James T; Shirai Mikiyasu; Yokoyama Chieko; Tsuchimochi Hirotsugu; Schwenke Daryl O; Shimouchi Akito; Kangawa Kenji; Tanabe Tadashi
Alpha2-adrenoreceptor mediated sympathoinhibition of heart rate during acute hypoxia is diminished in conscious prostacyclin synthase deficient mice.
Pflügers Archiv : European journal of physiology 2007;454(1):29-39.
2007: Jo Jun-Ichiro; Nagaya Noritoshi; Miyahara Yoshinori; Kataoka Masaharu; Harada-Shiba Mariko; Kangawa Kenji; Tabata Yasuhiko
Transplantation of genetically engineered mesenchymal stem cells improves cardiac function in rats with myocardial infarction: benefit of a novel nonviral vector, cationized dextran.
Tissue engineering 2007;13(2):313-22.
2007: Murashita Mari; Inoue Takeshi; Kusumi Ichiro; Nakagawa Shin; Itoh Kouichi; Tanaka Teruaki; Izumi Takeshi; Hosoda Hiroshi; Kangawa Kenji; Koyama Tsukasa
Glucose and lipid metabolism of long-term risperidone monotherapy in patients with schizophrenia.
Psychiatry and clinical neurosciences 2007;61(1):54-8.
2007: Toshinai Koji; Mondal Muhtashan S; Shimbara Takuya; Yamaguchi Hideki; Date Yukari; Kangawa Kenji; Nakazato Masamitsu
Ghrelin stimulates growth hormone secretion and food intake in aged rats.
Mechanisms of ageing and development 2007;128(2):182-6.
2007: Schwenke Daryl O; Pearson James T; Umetani Keiji; Kangawa Kenji; Shirai Mikiyasu
Imaging of the pulmonary circulation in the closed-chest rat using synchrotron radiation microangiography.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;102(2):787-93.
2007: Ida Takanori; Miyazato Mikiya; Naganobu Kiyokazu; Nakahara Keiko; Sato Miho; Lin Xing-Zi; Kaiya Hiroyuki; Doi Kentaro; Noda Soushi; Kubo Ayako; Murakami Noboru; Kangawa Kenji
Purification and characterization of feline ghrelin and its possible role.
Domestic animal endocrinology 2007;32(2):93-105.
2007: Schwenke Daryl O; Pearson James T; Tsuchimochi Hirotsugu; Kangawa Kenji; Shirai Mikiyasu
Pulmonary vascular reactivity of spontaneously hypertensive rats is exacerbated in response to the central administration of exogenous nitric oxide.
Clinical and experimental pharmacology & physiology 2007;34(1-2):88-94.
2007: Ohnishi Shunsuke; Yanagawa Bobby; Tanaka Koichi; Miyahara Yoshinori; Obata Hiroaki; Kataoka Masaharu; Kodama Makoto; Ishibashi-Ueda Hatsue; Kangawa Kenji; Kitamura Soichiro; Nagaya Noritoshi
Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis.
Journal of molecular and cellular cardiology 2007;42(1):88-97.
2006: Dezaki Katsuya; Sone Hideyuki; Koizumi Masaru; Nakata Masanori; Kakei Masafumi; Nagai Hideo; Hosoda Hiroshi; Kangawa Kenji; Yada Toshihiko
Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance.
Diabetes 2006;55(12):3486-93.
2006: Abe Minami; Sata Masataka; Suzuki Etsu; Takeda Ryo; Takahashi Masao; Nishimatsu Hiroaki; Nagata Daisuke; Kangawa Kenji; Matsuo Hisayuki; Nagai Ryozo; Hirata Yasunobu
Effects of adrenomedullin on acute ischaemia-induced collateral development and mobilization of bone-marrow-derived cells.
Clinical science (London, England : 1979) 2006;111(6):381-7.
2006: Sato Miho; Nakahara Keiko; Goto Shintaro; Kaiya Hiroyuki; Miyazato Mikiya; Date Yukari; Nakazato Masamitsu; Kangawa Kenji; Murakami Noboru
Effects of ghrelin and des-acyl ghrelin on neurogenesis of the rat fetal spinal cord.
Biochemical and biophysical research communications 2006;350(3):598-603.
2006: Miyahara Yoshinori; Ohnishi Shunsuke; Obata Hiroaki; Ishino Kozo; Sano Shunji; Mori Hidezo; Kangawa Kenji; Kitamura Soichiro; Nagaya Noritoshi
Beraprost sodium enhances neovascularization in ischemic myocardium by mobilizing bone marrow cells in rats.
Biochemical and biophysical research communications 2006;349(4):1242-9.
2006: Nishikimi Toshio; Mori Yosuke; Ishimura Kimihiko; Ishikawa Yayoi; Koshikawa Shogo; Akimoto Kazumi; Minamino Naoto; Kangawa Kenji; Matsuoka Hiroaki
Chronic effect of combined treatment with omapatrilat and adrenomedullin on the progression of heart failure in rats.
American journal of hypertension 2006;19(10):1039-48.
2006: Date Yukari; Shimbara Takuya; Koda Shuichi; Toshinai Koji; Ida Takanori; Murakami Noboru; Miyazato Mikiya; Kokame Koichi; Ishizuka Yuta; Ishida Yasushi; Kageyama Haruaki; Shioda Seiji; Kangawa Kenji; Nakazato Masamitsu
Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus.
Cell metabolism 2006;4(4):323-31.
2006: Miura Tohru; Maruyama Keisuke; Shimakura Sei-Ichi; Kaiya Hiroyuki; Uchiyama Minoru; Kangawa Kenji; Shioda Seiji; Matsuda Kouhei
Neuropeptide Y mediates ghrelin-induced feeding in the goldfish, Carassius auratus.
Neuroscience letters 2006;407(3):279-83.
2006: Akamizu Takashi; Kangawa Kenji
Translational research on the clinical applications of ghrelin.
Endocrine journal 2006;53(5):585-91.
2006: Ishizuka Tomoko; Nomura Sachiko; Hosoda Hiroshi; Kangawa Kenji; Watanabe Takeshi; Yamatodani Atsushi
A role of the histaminergic system for the control of feeding by orexigenic peptides.
Physiology & behavior 2006;89(3):295-300.
2006: Iwashima Yoshio; Horio Takeshi; Suzuki Yoshihiko; Kihara Shinji; Rakugi Hiromi; Kangawa Kenji; Funahashi Tohru; Ogihara Toshio; Kawano Yuhei
Adiponectin and inflammatory markers in peripheral arterial occlusive disease.
Atherosclerosis 2006;188(2):384-90.
2006: Tachibana Tetsuya; Kaiya Hiroyuki; Denbow D Michael; Kangawa Kenji; Furuse Mitsuhiro
Central ghrelin acts as an anti-dipsogenic peptide in chicks.
Neuroscience letters 2006;405(3):241-5.
2006: Kaiya Hiroyuki; Tsukada Takehiro; Yuge Shinya; Mondo Hiroko; Kangawa Kenji; Takei Yoshio
Identification of eel ghrelin in plasma and stomach by radioimmunoassay and histochemistry.
General and comparative endocrinology 2006;148(3):375-82.
2006: Matsuda Kouhei; Miura Tohru; Kaiya Hiroyuki; Maruyama Keisuke; Shimakura Sei-ichi; Uchiyama Minoru; Kangawa Kenji; Shioda Seiji
Regulation of food intake by acyl and des-acyl ghrelins in the goldfish.
Peptides 2006;27(9):2321-5.
2006: Kaiya Hiroyuki; Sakata Ichiro; Yamamoto Kazutoshi; Koda Aya; Sakai Takafumi; Kangawa Kenji; Kikuyama Sakae
Identification of immunoreactive plasma and stomach ghrelin, and expression of stomach ghrelin mRNA in the bullfrog, Rana catesbeiana.
General and comparative endocrinology 2006;148(2):236-44.
2006: Ohnishi Shunsuke; Nagaya Noritoshi; Kangawa Kenji
[Ghrelin]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():151-5.
2006: Ushiyama Mina; Sugawara Hideki; Inoue Kazuhiko; Kangawa Kenji; Yamada Katsushi; Miyata Atsuro
Characterization of the PAC1 variants expressed in the mouse heart.
Annals of the New York Academy of Sciences 2006;1070():586-90.
2006: Fujikawa Kohsho; Nagayama Tetsuya; Inoue Kazuhiko; Minamino Naoto; Kangawa Kenji; Niiro Masaki; Miyata Atsuro
C-type natriuretic peptide is specifically augmented by pituitary adenylate cyclase-activating polypeptide in rat astrocytes.
Annals of the New York Academy of Sciences 2006;1070():282-5.
2006: Murakami Shinsuke; Kimura Hiroshi; Kangawa Kenji; Nagaya Noritoshi
Physiological significance and therapeutic potential of adrenomedullin in pulmonary hypertension.
Cardiovascular & hematological disorders drug targets 2006;6(2):125-32.
2006: Doki Yuichiro; Takachi Ko; Ishikawa Osamu; Miyashiro Isao; Sasaki Yo; Ohigashi Hiroaki; Nakajima Hiromu; Hosoda Hiroshi; Kangawa Kenji; Sasakuma Fujiko; Motoori Masaaki; Imaoka Shingi
Ghrelin reduction after esophageal substitution and its correlation to postoperative body weight loss in esophageal cancer patients.
Surgery 2006;139(6):797-805.
2006: Chen Tianbao; Zhou Mei; Walker Brian; Harriot Pat; Mori Kenji; Miyazato Mikiya; Kangawa Kenji; Shaw Chris
Structural and functional analogs of the novel mammalian neuropeptide, neuromedin S (NmS), in the dermal venoms of Eurasian bombinid toads.
Biochemical and biophysical research communications 2006;345(1):377-84.
2006: Irako T; Akamizu T; Hosoda H; Iwakura H; Ariyasu H; Tojo K; Tajima N; Kangawa K
Ghrelin prevents development of diabetes at adult age in streptozotocin-treated newborn rats.
Diabetologia 2006;49(6):1264-73.
2006: Matsuda Kouhei; Miura Tohru; Kaiya Hiroyuki; Maruyama Keisuke; Uchiyama Minoru; Kangawa Kenji; Shioda Seiji
Stimulatory effect of n-octanoylated ghrelin on locomotor activity in the goldfish, Carassius auratus.
Peptides 2006;27(6):1335-40.
2006: Toshinai Koji; Yamaguchi Hideki; Sun Yuxiang; Smith Roy G; Yamanaka Akihiro; Sakurai Takeshi; Date Yukari; Mondal Muhtashan S; Shimbara Takuya; Kawagoe Takashi; Murakami Noboru; Miyazato Mikiya; Kangawa Kenji; Nakazato Masamitsu
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor.
Endocrinology 2006;147(5):2306-14.
2006: Schwenke D O; Pearson J T; Kangawa K; Shirai M
Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats?
Acta physiologica (Oxford, England) 2006;186(4):309-18.
2006: Takahashi H; Kurose Y; Kobayashi S; Sugino T; Kojima M; Kangawa K; Hasegawa Y; Terashima Y
Ghrelin enhances glucose-induced insulin secretion in scheduled meal-fed sheep.
The Journal of endocrinology 2006;189(1):67-75.
2006: Miyahara Yoshinori; Nagaya Noritoshi; Kataoka Masaharu; Yanagawa Bobby; Tanaka Koichi; Hao Hiroyuki; Ishino Kozo; Ishida Hideyuki; Shimizu Tatsuya; Kangawa Kenji; Sano Shunji; Okano Teruo; Kitamura Soichiro; Mori Hidezo
Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction.
Nature medicine 2006;12(4):459-65.
2006: Nakahara Keiko; Nakagawa Mari; Baba Yukiko; Sato Miho; Toshinai Koji; Date Yukari; Nakazato Masamitsu; Kojima Masayasu; Miyazato Mikiya; Kaiya Hiroyuki; Hosoda Hiroshi; Kangawa Kenji; Murakami Noboru
Maternal ghrelin plays an important role in rat fetal development during pregnancy.
Endocrinology 2006;147(3):1333-42.
2006: Kojima Masayasu; Kangawa Kenji
Drug insight: The functions of ghrelin and its potential as a multitherapeutic hormone.
Nature clinical practice. Endocrinology & metabolism 2006;2(2):80-8.
2006: Akamizu T; Murayama T; Teramukai S; Miura K; Bando I; Irako T; Iwakura H; Ariyasu H; Hosoda H; Tada H; Matsuyama A; Kojima S; Wada T; Wakatsuki Y; Matsubayashi K; Kawakita T; Shimizu A; Fukushima M; Yokode M; Kangawa K
Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure.
The Journal of endocrinology 2006;188(2):333-44.
2006: Geelissen S M E; Swennen Q; Geyten S Van der; Kühn E R; Kaiya H; Kangawa K; Decuypere E; Buyse J; Darras V M
Peripheral ghrelin reduces food intake and respiratory quotient in chicken.
Domestic animal endocrinology 2006;30(2):108-16.
2006: Takeda Ryo; Nishimatsu Hiroaki; Suzuki Etsu; Satonaka Hiroshi; Nagata Daisuke; Oba Shigeyoshi; Sata Masataka; Takahashi Masao; Yamamoto Yuji; Terauchi Yasuo; Kadowaki Takashi; Kangawa Kenji; Kitamura Tadaichi; Nagai Ryozo; Hirata Yasunobu
Ghrelin improves renal function in mice with ischemic acute renal failure.
Journal of the American Society of Nephrology : JASN 2006;17(1):113-21.
2006: Takachi Ko; Doki Yuichiro; Ishikawa Osamu; Miyashiro Isao; Sasaki Yo; Ohigashi Hiroaki; Murata Kohei; Nakajima Hiromu; Hosoda Hiroshi; Kangawa Kenji; Sasakuma Fujiko; Imaoka Shingi
Postoperative ghrelin levels and delayed recovery from body weight loss after distal or total gastrectomy.
The Journal of surgical research 2006;130(1):1-7.
2006: Shousha Saad; Nakahara Keiko; Sato Miho; Mori Kenji; Miyazato Mikiya; Kangawa Kenji; Murakami Noboru
Effect of neuromedin S on feeding regulation in the Japanese quail.
Neuroscience letters 2006;391(3):87-90.
2006: Murakami Shinsuke; Nagaya Noritoshi; Itoh Takefumi; Kataoka Masaharu; Iwase Takashi; Horio Takeshi; Miyahara Yoshinori; Sakai Yoshiki; Kangawa Kenji; Kimura Hiroshi
Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice.
American journal of physiology. Lung cellular and molecular physiology 2006;290(1):L59-65.
2006: Abe Yumiko; Sinozaki Hiromitsu; Takagi Takeshi; Minegishi Takashi; Kokame Koichi; Kangawa Kenji; Uesaka Miki; Miyamoto Kaoru
Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible genes in human amniotic epithelial cells.
Reproductive biology and endocrinology : RB&E 2006;4():27.
2006: Hosoda Hiroshi; Kojima Masayasu; Kangawa Kenji
Biological, physiological, and pharmacological aspects of ghrelin.
Journal of pharmacological sciences 2006;100(5):398-410.
2006: Nagaya Noritoshi; Kangawa Kenji
Therapeutic potential of ghrelin in the treatment of heart failure.
Drugs 2006;66(4):439-48.
2006: Nagaya Noritoshi; Kojima Masakazu; Kangawa Kenji
Ghrelin, a novel growth hormone-releasing peptide, in the treatment of cardiopulmonary-associated cachexia.
Internal medicine (Tokyo, Japan) 2006;45(3):127-34.
2005: Uehara T; Omori I; Nakamura K; Suda M; Hosoda Y; Minegishi T; Mikuni M; Kangawa K
Plasma des-acyl and acyl ghrelin in patients with eating disorders.
Eating and weight disorders : EWD 2005;10(4):264-6.
2005: Hayashi Yukio; Ueyama Hiroshi; Mashimo Takashi; Kangawa Kenji; Minamino Naoto
Circulating mature adrenomedullin is related to blood volume in full-term pregnancy.
Anesthesia and analgesia 2005;101(6):1816-20.
2005: Ishimura Kimihiko; Nishikimi Toshio; Akimoto Kazumi; Ono Hidehiko; Kangawa Kenji; Matsuoka Hiroaki
Renoprotective effect of long-term combined treatment with adrenomedullin and omapatrilat in hypertensive rats.
Journal of hypertension 2005;23(12):2287-96.
2005: Kataoka Masaharu; Nagaya Noritoshi; Satoh Toru; Itoh Takefumi; Murakami Shinsuke; Iwase Takashi; Miyahara Yoshinori; Kyotani Shingo; Sakai Yoshiki; Kangawa Kenji; Ogawa Satoshi
A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension.
American journal of respiratory and critical care medicine 2005;172(12):1575-80.
2005: Makino Tomohiro; Matsumoto Masaru; Suzuki Yuji; Kitajima Yasuo; Yamamoto Katsuhiko; Kuramoto Masashi; Minamitake Yoshiharu; Kangawa Kenji; Yabuta Masayuki
Semisynthesis of human ghrelin: condensation of a Boc-protected recombinant peptide with a synthetic O-acylated fragment.
Biopolymers 2005;79(5):238-47.
2005: Yokoyama Masayuki; Murakami Noboru; Naganobu Kiyokazu; Hosoda Hiroshi; Kangawa Kenji; Nakahara Keiko
Relationship between growth and plasma concentrations of ghrelin and growth hormone in juvenile beagle dogs.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2005;67(11):1189-92.
2005: Kamiyama Masafumi; Usui Noriaki; Kamata Shinkichi; Fukuzawa Masahiro; Nagaya Noritoshi; Kangawa Kenji
Adrenomedullin is up-regulated in nitrofen-induced fetal pulmonary hypoplasia.
Journal of pediatric surgery 2005;40(10):1562-7.
2005: Ida Takanori; Mori Kenji; Miyazato Mikiya; Egi Yutaka; Abe Shinsuke; Nakahara Keiko; Nishihara Masugi; Kangawa Kenji; Murakami Noboru
Neuromedin s is a novel anorexigenic hormone.
Endocrinology 2005;146(10):4217-23.
2005: Nagaya Noritoshi; Itoh Takefumi; Murakami Shinsuke; Oya Hideo; Uematsu Masaaki; Miyatake Kunio; Kangawa Kenji
Treatment of cachexia with ghrelin in patients with COPD.
Chest 2005;128(3):1187-93.
2005: Kaiya Hiroyuki; Small Brian C; Bilodeau A Lelania; Shepherd Brian S; Kojima Masayasu; Hosoda Hiroshi; Kangawa Kenji
Purification, cDNA cloning, and characterization of ghrelin in channel catfish, Ictalurus punctatus.
General and comparative endocrinology 2005;143(3):201-10.
2005: Yoshihara Fumiki; Horio Takeshi; Nakamura Satoko; Yoshii Masayoshi; Ogata Chinami; Nakahama Hajime; Inenaga Takashi; Kangawa Kenji; Kawano Yuhei
Adrenomedullin reflects cardiac dysfunction, excessive blood volume, and inflammation in hemodialysis patients.
Kidney international 2005;68(3):1355-63.
2005: Murakami Shinsuke; Nagaya Noritoshi; Itoh Takefumi; Iwase Takashi; Fujisato Toshiya; Nishioka Keisuke; Hamada Kaoru; Kangawa Kenji; Kimura Hiroshi
Adrenomedullin regenerates alveoli and vasculature in elastase-induced pulmonary emphysema in mice.
American journal of respiratory and critical care medicine 2005;172(5):581-9.
2005: Hosoda Hiroshi; Kangawa Kenji
[Ghrelin measurement]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 8():484-7.
2005: Nagaya Noritoshi; Kangawa Kenji; Itoh Takefumi; Iwase Takashi; Murakami Shinsuke; Miyahara Yoshinori; Fujii Takafumi; Uematsu Masaaki; Ohgushi Hajime; Yamagishi Masakazu; Tokudome Takeshi; Mori Hidezo; Miyatake Kunio; Kitamura Soichiro
Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy.
Circulation 2005;112(8):1128-35.
2005: Date Yukari; Toshinai Koji; Koda Shuichi; Miyazato Mikiya; Shimbara Takuya; Tsuruta Tomoko; Niijima Akira; Kangawa Kenji; Nakazato Masamitsu
Peripheral interaction of ghrelin with cholecystokinin on feeding regulation.
Endocrinology 2005;146(8):3518-25.
2005: Abiko Yuka; Suzuki Hidekazu; Masaoka Tatsuhiro; Nomura Sachiko; Kurabayashi Kumiko; Hosoda Hiroshi; Kangawa Kenji; Hibi Toshifumi
Enhanced plasma ghrelin levels in Helicobacter pylori-colonized, interleukin-1-receptor type 1-homozygous knockout (IL-1R1-/-) mice.
World journal of gastroenterology : WJG 2005;11(27):4148-53.
2005: Moriyama Maiko; Sato Takahiro; Inoue Hiromasa; Fukuyama Satoru; Teranishi Hitoshi; Kangawa Kenji; Kano Tatsuhiko; Yoshimura Akihiko; Kojima Masayasu
The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells.
The Journal of experimental medicine 2005;202(2):217-24.
2005: Yasu Takanori; Nishikimi Toshio; Kobayashi Nobuhiko; Ikeda Nahoko; Ueba Hiroto; Nakamura Tomohiro; Funayama Hiroshi; Kubo Norifumi; Kawakami Masanobu; Matsuoka Hiroaki; Kangawa Kenji; Saito Muneyasu
Up-regulated synthesis of mature-type adrenomedullin in coronary circulation immediately after reperfusion in patients with anterior acute myocardial infarction.
Regulatory peptides 2005;129(1-3):161-6.
2005: Fukuhara Seiichiro; Suzuki Hidekazu; Masaoka Tatsuhiro; Arakawa Mamoru; Hosoda Hiroshi; Minegishi Yuriko; Kangawa Kenji; Ishii Hiromasa; Kitajima Masaki; Hibi Toshifumi
Enhanced ghrelin secretion in rats with cysteamine-induced duodenal ulcers.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(1):G138-45.
2005: Shinomiya Toshiaki; Fukunaga Mikihiko; Akamizu Takashi; Irako Taiga; Yokode Masayuki; Kangawa Kenji; Nakai Yoshihide; Nakai Yoshikatsu
Plasma acylated ghrelin levels correlate with subjective symptoms of functional dyspepsia in female patients.
Scandinavian journal of gastroenterology 2005;40(6):648-53.
2005: Tokudome Takeshi; Horio Takeshi; Kishimoto Ichiro; Soeki Takeshi; Mori Kenji; Kawano Yuhei; Kohno Masakazu; Garbers David L; Nakao Kazuwa; Kangawa Kenji
Calcineurin-nuclear factor of activated T cells pathway-dependent cardiac remodeling in mice deficient in guanylyl cyclase A, a receptor for atrial and brain natriuretic peptides.
Circulation 2005;111(23):3095-104.
2005: Kurose Y; Iqbal J; Rao A; Murata Y; Hasegawa Y; Terashima Y; Kojima M; Kangawa K; Clarke I J
Changes in expression of the genes for the leptin receptor and the growth hormone-releasing peptide/ghrelin receptor in the hypothalamic arcuate nucleus with long-term manipulation of adiposity by dietary means.
Journal of neuroendocrinology 2005;17(6):331-40.
2005: Iwase Takashi; Nagaya Noritoshi; Fujii Takafumi; Itoh Takefumi; Murakami Shinsuke; Matsumoto Toshio; Kangawa Kenji; Kitamura Soichiro
Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia.
Cardiovascular research 2005;66(3):543-51.
2005: Nagaya Noritoshi; Mori Hidezo; Murakami Shinsuke; Kangawa Kenji; Kitamura Soichiro
Adrenomedullin: angiogenesis and gene therapy.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(6):R1432-7.
2005: Nishi Yoshihiro; Hiejima Hiroshi; Mifune Hiroharu; Sato Takahiro; Kangawa Kenji; Kojima Masayasu
Developmental changes in the pattern of ghrelin's acyl modification and the levels of acyl-modified ghrelins in murine stomach.
Endocrinology 2005;146(6):2709-15.
2005: Fukushima Nobuhiro; Hanada Reiko; Teranishi Hitoshi; Fukue Yoshihiko; Tachibana Toshiaki; Ishikawa Hiroshi; Takeda Shu; Takeuchi Yasuhiro; Fukumoto Seiji; Kangawa Kenji; Nagata Kensei; Kojima Masayasu
Ghrelin directly regulates bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(5):790-8.
2005: Yoshihara Fumiki; Suga Shin-ichi; Yasui Naomi; Horio Takeshi; Tokudome Takeshi; Nishikimi Toshio; Kawano Yuhei; Kangawa Kenji
Chronic administration of adrenomedullin attenuates the hypertension and increases renal nitric oxide synthase in Dahl salt-sensitive rats.
Regulatory peptides 2005;128(1):7-13.
2005: Nishi Yoshihiro; Hiejima Hiroshi; Hosoda Hiroshi; Kaiya Hiroyuki; Mori Kenji; Fukue Yoshihiko; Yanase Toshihiko; Nawata Hajime; Kangawa Kenji; Kojima Masayasu
Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin.
Endocrinology 2005;146(5):2255-64.
2005: Yokota Ichiro; Kitamura Seiko; Hosoda Hiroshi; Kotani Yumiko; Kangawa Kenji
Concentration of the n-octanoylated active form of ghrelin in fetal and neonatal circulation.
Endocrine journal 2005;52(2):271-6.
2005: Kojima Masayasu; Kangawa Kenji
Ghrelin: structure and function.
Physiological reviews 2005;85(2):495-522.
2005: Nishikimi Toshio; Tadokoro Kazuyoshi; Akimoto Kazumi; Mori Yosuke; Ishikawa Yayoi; Ishimura Kimihiko; Horio Takeshi; Kangawa Kenji; Matsuoka Hiroaki
Response of adrenomedullin system to cytokine in cardiac fibroblasts-role of adrenomedullin as an antifibrotic factor.
Cardiovascular research 2005;66(1):104-13.
2005: Shousha Saad; Nakahara Keiko; Kojima Masayasu; Miyazato Mikiya; Hosoda Hiroshi; Kangawa Kenji; Murakami Noboru
Different effects of peripheral and central ghrelin on regulation of food intake in the Japanese quail.
General and comparative endocrinology 2005;141(2):178-83.
2005: Hanabusa Kenichiro; Nagaya Noritoshi; Iwase Takashi; Itoh Takefumi; Murakami Shinsuke; Shimizu Yoshito; Taki Waro; Miyatake Kunio; Kangawa Kenji
Adrenomedullin enhances therapeutic potency of mesenchymal stem cells after experimental stroke in rats.
Stroke; a journal of cerebral circulation 2005;36(4):853-8.
2005: Iwakura Hiroshi; Hosoda Kiminori; Son Choel; Fujikura Junji; Tomita Tsutomu; Noguchi Michio; Ariyasu Hiroyuki; Takaya Kazuhiko; Masuzaki Hiroaki; Ogawa Yoshihiro; Hayashi Tatsuya; Inoue Gen; Akamizu Takashi; Hosoda Hiroshi; Kojima Masayasu; Itoh Hiroshi; Toyokuni Shinya; Kangawa Kenji; Nakao Kazuwa
Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice.
The Journal of biological chemistry 2005;280(15):15247-56.
2005: Yoshihara Fumiki; Nishikimi Toshio; Okano Ichiro; Hino Jun; Horio Takeshi; Tokudome Takeshi; Suga Shin-ichi; Matsuoka Hiroaki; Kangawa Kenji; Kawano Yuhei
Upregulation of intracardiac adrenomedullin and its receptor system in rats with volume overload-induced cardiac hypertrophy.
Regulatory peptides 2005;127(1-3):239-44.
2005: Shi Yi; Yoshihara Fumiki; Nakahama Hajime; Ichimaru Naotsugu; Yazawa Koji; Sada Masaharu; Goto Rieko; Kawano Yuhei; Moriyama Toshiki; Takahara Shiro; Okuyama Akihiko; Kangawa Kenji
A novel immunosuppressant FTY720 ameliorates proteinuria and alterations of intrarenal adrenomedullin in rats with autoimmune glomerulonephritis.
Regulatory peptides 2005;127(1-3):233-8.
2005: Kageyama Haruaki; Funahashi Hisayuki; Hirayama Masami; Takenoya Fumiko; Kita Tetsuro; Kato Sachi; Sakurai Junko; Lee Eun Young; Inoue Shuji; Date Yukari; Nakazato Masamitsu; Kangawa Kenji; Shioda Seiji
Morphological analysis of ghrelin and its receptor distribution in the rat pancreas.
Regulatory peptides 2005;126(1-2):67-71.
2005: Hashizume Tsutomu; Horiuchi Mami; Nonaka Sumie; Kasuya Etsuko; Kojima Masayasu; Hosoda Hiroshi; Kangawa Kenji
Effects of ghrelin on growth hormone secretion in vivo in ruminants.
Regulatory peptides 2005;126(1-2):61-5.
2005: Mondal Muhtashan S; Date Yukari; Yamaguchi Hideki; Toshinai Koji; Tsuruta Tomoko; Kangawa Kenji; Nakazato Masamitsu
Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus.
Regulatory peptides 2005;126(1-2):55-9.
2005: Ueno Hiroaki; Yamaguchi Hideki; Kangawa Kenji; Nakazato Masamitsu
Ghrelin: a gastric peptide that regulates food intake and energy homeostasis.
Regulatory peptides 2005;126(1-2):11-9.
2005: Fujii Takafumi; Nagaya Noritoshi; Iwase Takashi; Murakami Shinsuke; Miyahara Yoshinori; Nishigami Kazuhiro; Ishibashi-Ueda Hatsue; Shirai Mikiyasu; Itoh Takefumi; Ishino Kozo; Sano Shunji; Kangawa Kenji; Mori Hidezo
Adrenomedullin enhances therapeutic potency of bone marrow transplantation for myocardial infarction in rats.
American journal of physiology. Heart and circulatory physiology 2005;288(3):H1444-50.
2005: Iwanaga Kikuko; Takamura Noboru; Abe Yasuyo; Zhaojia Ye; Shinzato Ken; Hosoda Hiroshi; Kangawa Kenji; Ohtsuru Akira; Kohno Shigeru; Yamashita Shunichi; Aoyagi Kiyoshi
Plasma concentrations of adrenomedullin and ghrelin in hemodialysis patients with sustained and episodic hypotension.
Endocrine journal 2005;52(1):23-8.
2005: Soeki Takeshi; Kishimoto Ichiro; Okumura Hiroyuki; Tokudome Takeshi; Horio Takeshi; Mori Kenji; Kangawa Kenji
C-type natriuretic peptide, a novel antifibrotic and antihypertrophic agent, prevents cardiac remodeling after myocardial infarction.
Journal of the American College of Cardiology 2005;45(4):608-16.
2005: Shousha Saad; Nakahara Keiko; Miyazato Mikiya; Kangawa Kenji; Murakami Noboru
Endogenous neuromedin U has anorectic effects in the Japanese quail.
General and comparative endocrinology 2005;140(3):156-63.
2005: Saito Ei-Suke; Kaiya Hiroyuki; Tachibana Tetsuya; Tomonaga Shozo; Denbow D Michel; Kangawa Kenji; Furuse Mitsuhiro
Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks.
Regulatory peptides 2005;125(1-3):201-8.
2005: Masaoka Tatsuhiro; Suzuki Hidekazu; Imaeda Hiroyuki; Hosoda Hiroshi; Ohara Tadashi; Morishita Tetsuo; Ishii Hiromasa; Kangawa Kenji; Hibi Toshifumi
Long-term strict monitoring of plasma ghrelin and other serological markers of gastric diseases after Helicobacter pylori eradication.
Hepato-gastroenterology 2005;52(61):1-4.
2005: Yokoyama Masayuki; Nakahara Keiko; Kojima Masayasu; Hosoda Hiroshi; Kangawa Kenji; Murakami Noboru
Influencing the between-feeding and endocrine responses of plasma ghrelin in healthy dogs.
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(1):155-60.
2005: Iwase Takashi; Nagaya Noritoshi; Fujii Takafumi; Itoh Takefumi; Ishibashi-Ueda Hatsue; Yamagishi Masakazu; Miyatake Kunio; Matsumoto Toshio; Kitamura Soichiro; Kangawa Kenji
Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia.
Circulation 2005;111(3):356-62.
2005: Mori Kenji; Miyazato Mikiya; Ida Takanori; Murakami Noboru; Serino Ryota; Ueta Yoichi; Kojima Masayasu; Kangawa Kenji
Identification of neuromedin S and its possible role in the mammalian circadian oscillator system.
The EMBO journal 2005;24(2):325-35.
2005: Fukuhara Shigetomo; Sakurai Atsuko; Sano Hideto; Yamagishi Akiko; Somekawa Satoshi; Takakura Nobuyuki; Saito Yoshihiko; Kangawa Kenji; Mochizuki Naoki
Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway.
Molecular and cellular biology 2005;25(1):136-46.
2005: Nishikimi Toshio; Wang Xin; Akimoto Kazumi; Tadokoro Kazuyoshi; Mori Yosuke; Ishikawa Yayoi; Ishimura Kimihiko; Yoshihara Fumiki; Minamino Naoto; Kangawa Kenji; Matsuoka Hiroaki
Alteration of renal adrenomedullin and its receptor system in the severely hypertensive rat: effect of diuretic.
Regulatory peptides 2005;124(1-3):89-98.
2005: Horio Takeshi; Maki Toshiyuki; Kishimoto Ichiro; Tokudome Takeshi; Okumura Hiroyuki; Yoshihara Fumiki; Suga Shin-ichi; Takeo Satoshi; Kawano Yuhei; Kangawa Kenji
Production and autocrine/paracrine effects of endogenous insulin-like growth factor-1 in rat cardiac fibroblasts.
Regulatory peptides 2005;124(1-3):65-72.
2005: Akamizu Takashi; Shinomiya Toshiaki; Irako Taiga; Fukunaga Mikihiko; Nakai Yoshihide; Nakai Yoshikatsu; Kangawa Kenji
Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay.
The Journal of clinical endocrinology and metabolism 2005;90(1):6-9.
2005: Ariyasu Hiroyuki; Takaya Kazuhiko; Iwakura Hiroshi; Hosoda Hiroshi; Akamizu Takashi; Arai Yuji; Kangawa Kenji; Nakao Kazuwa
Transgenic mice overexpressing des-acyl ghrelin show small phenotype.
Endocrinology 2005;146(1):355-64.
2005: Murashita Mari; Kusumi Ichiro; Inoue Takeshi; Takahashi Yoshito; Hosoda Hiroshi; Kangawa Kenji; Koyama Tsukasa
Olanzapine increases plasma ghrelin level in patients with schizophrenia.
Psychoneuroendocrinology 2005;30(1):106-10.
2005: Matsuoka Hisafumi; Hosoda Hiroshi; Sugawara Hisae; Iwama Saika; Kim Hye Sook; Kangawa Kenji; Sugihara Shigetaka
Short-term secretory regulation of ghrelin during growth hormone provocative tests in prepubertal children with various growth hormone secretory capacities.
Hormone research 2005;64(6):274-9.
2004: Mizutani Tetsuya; Yoshino Miki; Satake Tomoko; Nakagawa Miyuki; Ishimura Ryuta; Tohyama Chiharu; Kokame Koichi; Kangawa Kenji; Miyamoto Kaoru
Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible and -suppressive genes in the rat placenta: induction of interferon-regulated genes with possible inhibitory roles for angiogenesis in the placenta.
Endocrine journal 2004;51(6):569-77.
2004: Nagaya Noritoshi; Moriya Junji; Yasumura Yoshio; Uematsu Masaaki; Ono Fumiaki; Shimizu Wataru; Ueno Kazuyuki; Kitakaze Masafumi; Miyatake Kunio; Kangawa Kenji
Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure.
Circulation 2004;110(24):3674-9.
2004: Dezaki Katsuya; Hosoda Hiroshi; Kakei Masafumi; Hashiguchi Suzuko; Watanabe Masatomo; Kangawa Kenji; Yada Toshihiko
Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents.
Diabetes 2004;53(12):3142-51.
2004: Kojima Masayasu; Hosoda Hiroshi; Kangawa Kenji
Clinical endocrinology and metabolism. Ghrelin, a novel growth-hormone-releasing and appetite-stimulating peptide from stomach.
Best practice & research. Clinical endocrinology & metabolism 2004;18(4):517-30.
2004: Itoh Takefumi; Nagaya Noritoshi; Murakami Shinsuke; Fujii Takafumi; Iwase Takashi; Ishibashi-Ueda Hatsue; Yutani Chikao; Yamagishi Masakazu; Kimura Hiroshi; Kangawa Kenji
C-type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats.
American journal of respiratory and critical care medicine 2004;170(11):1204-11.
2004: Murakami Shinsuke; Nagaya Noritoshi; Itoh Takefumi; Fujii Takafumi; Iwase Takashi; Hamada Kaoru; Kimura Hiroshi; Kangawa Kenji
C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice.
American journal of physiology. Lung cellular and molecular physiology 2004;287(6):L1172-7.
2004: Nagaya Noritoshi; Fujii Takafumi; Iwase Takashi; Ohgushi Hajime; Itoh Takefumi; Uematsu Masaaki; Yamagishi Masakazu; Mori Hidezo; Kangawa Kenji; Kitamura Soichiro
Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis.
American journal of physiology. Heart and circulatory physiology 2004;287(6):H2670-6.
2004: Nagaya Noritoshi; Kangawa Kenji
Adrenomedullin in the treatment of pulmonary hypertension.
Peptides 2004;25(11):2013-8.
2004: Yamazaki M; Kobayashi H; Tanaka T; Kangawa K; Inoue K; Sakai T
Ghrelin-induced growth hormone release from isolated rat anterior pituitary cells depends on intracellullar and extracellular Ca2+ sources.
Journal of neuroendocrinology 2004;16(10):825-31.
2004: Takeno Ryoko; Okimura Yasuhiko; Iguchi Genzo; Kishimoto Masahiko; Kudo Takumi; Takahashi Kentaro; Takahashi Yutaka; Kaji Hidesuke; Ohno Masakazu; Ikuta Hajime; Kuroda Yoshikazu; Obara Tetsuji; Hosoda Hiroshi; Kangawa Kenji; Chihara Kazuo
Intravenous administration of ghrelin stimulates growth hormone secretion in vagotomized patients as well as normal subjects.
European journal of endocrinology / European Federation of Endocrine Societies 2004;151(4):447-50.
2004: Hanada Reiko; Teranishi Hitoshi; Pearson James Todd; Kurokawa Mamoru; Hosoda Hiroshi; Fukushima Nobuhiro; Fukue Yoshihiko; Serino Ryota; Fujihara Hiroaki; Ueta Yoichi; Ikawa Masahito; Okabe Masaru; Murakami Noboru; Shirai Mikiyasu; Yoshimatsu Hironobu; Kangawa Kenji; Kojima Masayasu
Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway.
Nature medicine 2004;10(10):1067-73.
2004: Nakahara Keiko; Kojima Masayasu; Hanada Reiko; Egi Yutaka; Ida Takanori; Miyazato Mikiya; Kangawa Kenji; Murakami Noboru
Neuromedin U is involved in nociceptive reflexes and adaptation to environmental stimuli in mice.
Biochemical and biophysical research communications 2004;323(2):615-20.
2004: Itoh Takefumi; Nagaya Noritoshi; Yoshikawa Masanori; Fukuoka Atsuhiko; Takenaka Hideaki; Shimizu Yoshito; Haruta Yoshinori; Oya Hideo; Yamagishi Masakazu; Hosoda Hiroshi; Kangawa Kenji; Kimura Hiroshi
Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2004;170(8):879-82.
2004: Nagaya Noritoshi; Kangawa Kenji
[Ghrelin in the treatment of cardiovascular disease]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():430-4.
2004: Akamizu Takashi; Irako Taiga; Hosoda Hiroshi; Takaya Kazuhiko; Kangawa Kenji
[Translational research of ghrelin in endocrine and metabolic diseases]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():424-9.
2004: Hosoda Hiroshi; Kangawa Kenji
[Role of ghrelin in cancer]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():421-3.
2004: Takaya Kazuhiko; Nakao Kazuwa; Kangawa Kenji
[Roles of ghrelin in growth and aging]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():414-6.
2004: Ariyasu Hiroyuki; Nakao Kazuwa; Kangawa Kenji
[Role of ghrelin in anorexia nervosa]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():410-3.
2004: Murakami Noboru; Nakahara Keiko; Kangawa Kenji
[Role of ghrelin in fetuses and neonates]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():392-5.
2004: Takaya Kazuhiko; Nakao Kazuwa; Kangawa Kenji
[Effects of ghrelin in aged subjects]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():377-9.
2004: Takaya Kazuhiko; Nakao Kazuwa; Kangawa Kenji
[Neuroendocrine effects of ghrelin]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():369-72.
2004: Hosoda Hiroshi; Kangawa Kenji
[Ghrelin measurement]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():354-6.
2004: Hosoda Hiroshi; Kangawa Kenji
[Distribution of ghrelin producing-cells and regulation of their biosynthesis]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():336-9.
2004: Kojima Masayasu; Kangawa Kenji
[Structure of ghrelin]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():324-7.
2004: Kangawa Kenji; Kojima Masayasu; Hosoda Hiroshi
[Discovery of ghrelin and its physiological significance]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():317-23.
2004: Okano Yukari; Kangawa Kenji
[Role of adrenomedullin in septic shock]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():276-9.
2004: Nagaya Noritoshi; Kangawa Kenji
[Adrenomedullin in pulmonary hypertension]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():264-8.
2004: Kangawa Kenji; Minamino Naoto; Matsuo Hisayuki
[Structure and function of the natriuretic peptide family]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():10-7.
2004: Suzuki Hidekazu; Masaoka Tatsuhiro; Hosoda Hiroshi; Nomura Sachiko; Ohara Tadashi; Kangawa Kenji; Ishii Hiromasa; Hibi Toshifumi
Plasma ghrelin concentration correlates with the levels of serum pepsinogen I and pepsinogen I/II ratio--a possible novel and non-invasive marker for gastric atrophy.
Hepato-gastroenterology 2004;51(59):1249-54.
2004: Takami Yoichi; Horio Takeshi; Iwashima Yoshio; Takiuchi Shin; Kamide Kei; Yoshihara Fumiki; Nakamura Satoko; Nakahama Hajime; Inenaga Takashi; Kangawa Kenji; Kawano Yuhei
Diagnostic and prognostic value of plasma brain natriuretic peptide in non-dialysis-dependent CRF.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2004;44(3):420-8.
2004: Kamei M; Hayashi Y; Kikumoto K; Kawai Y; Kangawa K; Kuro M; Minaminoals N
Effect of cardiopulmonary bypass on pulmonary clearance of adrenomedullin in humans.
Acta anaesthesiologica Scandinavica 2004;48(8):980-5.
2004: Komamura Kazuo; Tatsumi Rie; Miyazaki Jun-ichi; Matsumoto Kunio; Yamato Eiji; Nakamura Toshikazu; Shimizu Yoshito; Nakatani Takeshi; Kitamura Soichiro; Tomoike Hitonobu; Kitakaze Masafumi; Kangawa Kenji; Miyatake Kunio
Treatment of dilated cardiomyopathy with electroporation of hepatocyte growth factor gene into skeletal muscle.
Hypertension 2004;44(3):365-71.
2004: Kanamoto Naotetsu; Akamizu Takashi; Tagami Tetsuya; Hataya Yuji; Moriyama Kenji; Takaya Kazuhiko; Hosoda Hiroshi; Kojima Masayasu; Kangawa Kenji; Nakao Kazuwa
Genomic structure and characterization of the 5'-flanking region of the human ghrelin gene.
Endocrinology 2004;145(9):4144-53.
2004: Suzuki Yoshihiko; Horio Takeshi; Nonogi Hiroshi; Hayashi Tokio; Kitamura Kazuo; Eto Tanenao; Kangawa Kenji; Kawano Yuhei
Adrenomedullin as a sensitive marker for coronary and peripheral arterial complications in patients with atherosclerotic risks.
Peptides 2004;25(8):1321-6.
2004: Nishikimi Toshio; Asakawa Hiroshi; Iida Hiroshi; Matsushita Yasushi; Shibasaki Ikuko; Tadokoro Kazuyoshi; Mori Yosuke; Mori Hideaki; Mochizuki Yoshihiko; Okamura Yoshitaka; Miyoshi Shinichiro; Kangawa Kenji; Matsuoka Hiroaki
Different secretion patterns of two molecular forms of cardiac adrenomedullin in pressure- and volume-overloaded human heart failure.
Journal of cardiac failure 2004;10(4):321-7.
2004: Kaiya Hiroyuki; Sakata Ichiro; Kojima Masayasu; Hosoda Hiroshi; Sakai Takafumi; Kangawa Kenji
Structural determination and histochemical localization of ghrelin in the red-eared slider turtle, Trachemys scripta elegans.
General and comparative endocrinology 2004;138(1):50-7.
2004: Sakata Ichiro; Mori Tsukasa; Kaiya Hiroyuki; Yamazaki Mami; Kangawa Kenji; Inoue Kinji; Sakai Takafumi
Localization of ghrelin-producing cells in the stomach of the rainbow trout (Oncorhynchus mykiss).
Zoological science 2004;21(7):757-62.
2004: Sugino T; Hasegawa Y; Kurose Y; Kojima M; Kangawa K; Terashima Y
Effects of ghrelin on food intake and neuroendocrine function in sheep.
Animal reproduction science 2004;82-83():183-94.
2004: Nakamura Ryosai; Kato Johji; Kitamura Kazuo; Onitsuka Hisamitsu; Imamura Takuroh; Cao Yuanning; Marutsuka Kousuke; Asada Yujiro; Kangawa Kenji; Eto Tanenao
Adrenomedullin administration immediately after myocardial infarction ameliorates progression of heart failure in rats.
Circulation 2004;110(4):426-31.
2004: Nakai Yoshikatsu; Hosoda Hiroshi; Nin Kazuko; Ooya Chizuru; Hayashi Hiromi; Akamizu Takashi; Kangawa Kenji
Short-term secretory regulation of the active form of ghrelin and total ghrelin during an oral glucose tolerance test in patients with anorexia nervosa.
European journal of endocrinology / European Federation of Endocrine Societies 2004;150(6):913-4.
2004: Pearson James T; Shirai Mikiyasu; Ito Haruo; Tokunaga Noriyuki; Tsuchimochi Hirotsugu; Nishiura Naoki; Schwenke Daryl O; Ishibashi-Ueda Hatsue; Akiyama Ryuichi; Mori Hidezo; Kangawa Kenji; Suga Hiroyuki; Yagi Naoto
In situ measurements of crossbridge dynamics and lattice spacing in rat hearts by x-ray diffraction: sensitivity to regional ischemia.
Circulation 2004;109(24):2976-9.
2004: Tokudome Takeshi; Horio Takeshi; Yoshihara Fumiki; Suga Shin-Ichi; Kawano Yuhei; Kohno Masakazu; Kangawa Kenji
Direct effects of high glucose and insulin on protein synthesis in cultured cardiac myocytes and DNA and collagen synthesis in cardiac fibroblasts.
Metabolism: clinical and experimental 2004;53(6):710-5.
2004: Hosoda Hiroshi; Doi Kentaro; Nagaya Noritoshi; Okumura Hiroyuki; Nakagawa Eiichiro; Enomoto Mitsunobu; Ono Fumiaki; Kangawa Kenji
Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples.
Clinical chemistry 2004;50(6):1077-80.
2004: Nakahara Keiko; Hanada Reiko; Murakami Noboru; Teranishi Hitoshi; Ohgusu Hideko; Fukushima Nobuhiro; Moriyama Maiko; Ida Takanori; Kangawa Kenji; Kojima Masayasu
The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system.
Biochemical and biophysical research communications 2004;318(1):156-61.
2004: Hino Jun; Kangawa Kenji; Matsuo Hisayuki; Nohno Tsutomu; Nishimatsu Shin-ichiro
Bone morphogenetic protein-3 family members and their biological functions.
Frontiers in bioscience : a journal and virtual library 2004;9():1520-9.
2004: Tokudome Takeshi; Horio Takeshi; Soeki Takeshi; Mori Kenji; Kishimoto Ichiro; Suga Shin-ichi; Yoshihara Fumiki; Kawano Yuhei; Kohno Masakazu; Kangawa Kenji
Inhibitory effect of C-type natriuretic peptide (CNP) on cultured cardiac myocyte hypertrophy: interference between CNP and endothelin-1 signaling pathways.
Endocrinology 2004;145(5):2131-40.
2004: Tokudome Takeshi; Horio Takeshi; Fukunaga Megumu; Okumura Hiroyuki; Hino Jun; Mori Kenji; Yoshihara Fumiki; Suga Shin-Ichi; Kawano Yuhei; Kohno Masakazu; Kangawa Kenji
Ventricular nonmyocytes inhibit doxorubicin-induced myocyte apoptosis: involvement of endogenous endothelin-1 as a paracrine factor.
Endocrinology 2004;145(5):2458-66.
2004: Chen Lei; Hashida Seiichi; Kitamura Kazuo; Eto Tanenao; Kangawa Kenji; Serino Ryota; Kis Bela; Yamashita Hiroshi; Ueta Yoichi
Disassociated increases of adrenomedullin in the rat cerebrospinal fluid and plasma after salt loading and systemic administration of lipopolysaccharide.
Peptides 2004;25(4):609-14.
2004: Akamizu Takashi; Takaya Kazuhiko; Irako Taiga; Hosoda Hiroshi; Teramukai Satoshi; Matsuyama Akiko; Tada Harue; Miura Kazumi; Shimizu Akira; Fukushima Masanori; Yokode Masayuki; Tanaka Koichi; Kangawa Kenji
Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects.
European journal of endocrinology / European Federation of Endocrine Societies 2004;150(4):447-55.
2004: Shi Yi; Yoshihara Fumiki; Nakahama Hajime; Goto Rieko; Sada Masaharu; Kawano Yuhei; Moriyama Toshiki; Yazawa Koji; Ichimaru Naotsugu; Takahara Shiro; Kangawa Kenji
Mycophenolate mofetil prevents autoimmune glomerulonephritis and alterations of intrarenal adrenomedullin in rats.
European journal of pharmacology 2004;489(1-2):127-33.
2004: Miyata Atsuro; Sugawara Hideki; Iwata Shin-ichi; Shimizu Takao; Kangawa Kenji
[The regulatory mechanism for neuron specific expression of PACAP gene]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2004;123(4):235-42.
2004: Niu Pei; Shindo Takayuki; Iwata Hiroshi; Iimuro Satoshi; Takeda Norifumi; Zhang Yuelan; Ebihara Aya; Suematsu Yoshihiro; Kangawa Kenji; Hirata Yasunobu; Nagai Ryozo
Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis, and renal damage.
Circulation 2004;109(14):1789-94.
2004: Suzuki Yoshihiko; Horio Takeshi; Hayashi Tokio; Nonogi Hiroshi; Kitamura Kazuo; Eto Tanenao; Kangawa Kenji; Kawano Yuhei
Plasma adrenomedullin concentration is increased in patients with peripheral arterial occlusive disease associated with vascular inflammation.
Regulatory peptides 2004;118(1-2):99-104.
2004: Shibata Kazuhiko; Hosoda Hiroshi; Kojima Masayasu; Kangawa Kenji; Makino Yasuo; Makino Ikuko; Kawarabayashi Tatsuhiko; Futagami Kojiro; Gomita Yutaka
Regulation of ghrelin secretion during pregnancy and lactation in the rat: possible involvement of hypothalamus.
Peptides 2004;25(2):279-87.
2004: Tokunaga Noriyuki; Nagaya Noritoshi; Shirai Mikiyasu; Tanaka Etsuro; Ishibashi-Ueda Hatsue; Harada-Shiba Mariko; Kanda Munetake; Ito Takefumi; Shimizu Wataru; Tabata Yasuhiko; Uematsu Masaaki; Nishigami Kazuhiro; Sano Shunji; Kangawa Kenji; Mori Hidezo
Adrenomedullin gene transfer induces therapeutic angiogenesis in a rabbit model of chronic hind limb ischemia: benefits of a novel nonviral vector, gelatin.
Circulation 2004;109(4):526-31.
2004: Suzuki H; Masaoka T; Hosoda H; Ota T; Minegishi Y; Nomura S; Kangawa K; Ishii H
Helicobacter pylori infection modifies gastric and plasma ghrelin dynamics in Mongolian gerbils.
Gut 2004;53(2):187-94.
2004: Hiragushi Keita; Wada Jun; Eguchi Jun; Matsuoka Takashi; Yasuhara Akihiro; Hashimoto Izumi; Yamashita Tetsuji; Hida Kazuyuki; Nakamura Yoshio; Shikata Kenichi; Minamino Naoto; Kangawa Kenji; Makino Hirofumi
The role of adrenomedullin and receptors in glomerular hyperfiltration in streptozotocin-induced diabetic rats.
Kidney international 2004;65(2):540-50.
2004: Nagaya Noritoshi; Kyotani Shingo; Uematsu Masaaki; Ueno Kazuyuki; Oya Hideo; Nakanishi Norifumi; Shirai Mikiyasu; Mori Hidezo; Miyatake Kunio; Kangawa Kenji
Effects of adrenomedullin inhalation on hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension.
Circulation 2004;109(3):351-6.
2004: Kamata Shinkichi; Kamiyama Masahumi; Usui Noriaki; Kitayama Yasuhiro; Okuyama Hirohomi; Kubota Akio; Kangawa Kenji
Is adrenomedullin involved in the pathophysiology of persistent pulmonary hypertension of the newborn?
Pediatric surgery international 2004;20(1):24-6.
2004: Okumura Hiroyuki; Nagaya Noritoshi; Itoh Takefumi; Okano Ichiro; Hino Jun; Mori Kenji; Tsukamoto Yoshitane; Ishibashi-Ueda Hatsue; Miwa Senri; Tambara Keiichi; Toyokuni Shinya; Yutani Chikao; Kangawa Kenji
Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway.
Circulation 2004;109(2):242-8.
2004: Hanada Takeshi; Toshinai Koji; Date Yukari; Kajimura Naoko; Tsukada Toshihiko; Hayashi Yujiro; Kangawa Kenji; Nakazato Masamitsu
Upregulation of ghrelin expression in cachectic nude mice bearing human melanoma cells.
Metabolism: clinical and experimental 2004;53(1):84-8.
2004: Itoh Takefumi; Nagaya Noritoshi; Fujii Takafumi; Iwase Takashi; Nakanishi Norifumi; Hamada Kaoru; Kangawa Kenji; Kimura Hiroshi
A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats.
American journal of respiratory and critical care medicine 2004;169(1):34-8.
2003: Kaiya Hiroyuki; Kojima Masayasu; Hosoda Hiroshi; Moriyama Shunsuke; Takahashi Akiyoshi; Kawauchi Hiroshi; Kangawa Kenji
Peptide purification, complementary deoxyribonucleic acid (DNA) and genomic DNA cloning, and functional characterization of ghrelin in rainbow trout.
Endocrinology 2003;144(12):5215-26.
2003: Hataya Yuji; Akamizu Takashi; Hosoda Hiroshi; Kanamoto Naotetsu; Moriyama Kenji; Kangawa Kenji; Takaya Kazuhiko; Nakao Kazuwa
Alterations of plasma ghrelin levels in rats with lipopolysaccharide-induced wasting syndrome and effects of ghrelin treatment on the syndrome.
Endocrinology 2003;144(12):5365-71.
2003: Hanada Takeshi; Date Yukari; Shimbara Takuya; Sakihara Satoru; Murakami Noboru; Hayashi Yujiro; Kanai Yasushi; Suda Toshihiro; Kangawa Kenji; Nakazato Masamitsu
Central actions of neuromedin U via corticotropin-releasing hormone.
Biochemical and biophysical research communications 2003;311(4):954-8.
2003: Kitamura Seiko; Yokota Ichiro; Hosoda Hiroshi; Kotani Yumiko; Matsuda Junko; Naito Etsuo; Ito Michinori; Kangawa Kenji; Kuroda Yasuhiro
Ghrelin concentration in cord and neonatal blood: relation to fetal growth and energy balance.
The Journal of clinical endocrinology and metabolism 2003;88(11):5473-7.
2003: Nishikimi Toshio; Yoshihara Fumiki; Horinaka Shigeo; Kobayashi Naohiko; Mori Yosuke; Tadokoro Kazuyoshi; Akimoto Kazumi; Minamino Naoto; Kangawa Kenji; Matsuoka Hiroaki
Chronic administration of adrenomedullin attenuates transition from left ventricular hypertrophy to heart failure in rats.
Hypertension 2003;42(5):1034-41.
2003: Nagaya Noritoshi; Okumura Hiroyuki; Uematsu Masaaki; Shimizu Wataru; Ono Fumiaki; Shirai Mikiyasu; Mori Hidezo; Miyatake Kunio; Kangawa Kenji
Repeated inhalation of adrenomedullin ameliorates pulmonary hypertension and survival in monocrotaline rats.
American journal of physiology. Heart and circulatory physiology 2003;285(5):H2125-31.
2003: Watanabe K; Nishikimi T; Takamuro M; Yasuda K; Ishikawa Y; Tanabe S; Yamada O; Nagaya N; Matsuoka H; Kangawa K; Echigo S
Two molecular forms of adrenomedullin in congenital heart disease.
Pediatric cardiology 2003;24(6):559-65.
2003: Shimizu Yoshito; Nagaya Noritoshi; Teranishi Yasuhiro; Imazu Michinori; Yamamoto Hideya; Shokawa Tomoki; Kangawa Kenji; Kohno Nobuoki; Yoshizumi Masao
Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats.
Biochemical and biophysical research communications 2003;310(3):830-5.
2003: Enomoto Mitsunobu; Nagaya Noritoshi; Uematsu Masaaki; Okumura Hiroyuki; Nakagawa Eiichiroh; Ono Fumiaki; Hosoda Hiroshi; Oya Hideo; Kojima Masayasu; Kanmatsuse Katsuo; Kangawa Kenji
Cardiovascular and hormonal effects of subcutaneous administration of ghrelin, a novel growth hormone-releasing peptide, in healthy humans.
Clinical science (London, England : 1979) 2003;105(4):431-5.
2003: Nagamune Kisaburo; Ohishi Kazuhito; Ashida Hisashi; Hong Yeonchul; Hino Jun; Kangawa Kenji; Inoue Norimitsu; Maeda Yusuke; Kinoshita Taroh
GPI transamidase of Trypanosoma brucei has two previously uncharacterized (trypanosomatid transamidase 1 and 2) and three common subunits.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10682-7.
2003: Hino Jun; Nishimatsu Shin-ichiro; Nagai Takeharu; Matsuo Hisayuki; Kangawa Kenji; Nohno Tsutomu
Coordination of BMP-3b and cerberus is required for head formation of Xenopus embryos.
Developmental biology 2003;260(1):138-57.
2003: Nagaya Noritoshi; Kangawa Kenji; Kanda Munetake; Uematsu Masaaki; Horio Takeshi; Fukuyama Naoto; Hino Jun; Harada-Shiba Mariko; Okumura Hiroyuki; Tabata Yasuhiko; Mochizuki Naoki; Chiba Yoshihide; Nishioka Keisuke; Miyatake Kunio; Asahara Takayuki; Hara Hiroshi; Mori Hidezo
Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells.
Circulation 2003;108(7):889-95.
2003: Hosoda Hiroshi; Kangawa Kenji
[Ghrelin and GH secretion]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 2003;40(4):341-3.
2003: Nagaya Noritoshi; Kangawa Kenji
Ghrelin, a novel growth hormone-releasing peptide, in the treatment of chronic heart failure.
Regulatory peptides 2003;114(2-3):71-7.
2003: Kaiya Hiroyuki; Kojima Masayasu; Hosoda Hiroshi; Riley Larry G; Hirano Tetsuya; Grau E Gordon; Kangawa Kenji
Identification of tilapia ghrelin and its effects on growth hormone and prolactin release in the tilapia, Oreochromis mossambicus.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2003;135(3):421-9.
2003: Nakai Yoshikatsu; Hosoda Hiroshi; Nin Kazuko; Ooya Chizuru; Hayashi Hiromi; Akamizu Takashi; Kangawa Kenji
Plasma levels of active form of ghrelin during oral glucose tolerance test in patients with anorexia nervosa.
European journal of endocrinology / European Federation of Endocrine Societies 2003;149(1):R1-3.
2003: Hashizume Tsutomu; Horiuchi Mami; Tate Naomi; Nonaka Sumie; Kojima Masayasu; Hosoda Hiroshi; Kangawa Kenji
Effects of ghrelin on growth hormone secretion from cultured adenohypophysial cells in cattle.
Endocrine journal 2003;50(3):289-95.
2003: Abe Minami; Sata Masataka; Nishimatsu Hiroaki; Nagata Daisuke; Suzuki Etsu; Terauchi Yasuo; Kadowaki Takashi; Minamino Naoto; Kangawa Kenji; Matsuo Hisayuki; Hirata Yasunobu; Nagai Ryozo
Adrenomedullin augments collateral development in response to acute ischemia.
Biochemical and biophysical research communications 2003;306(1):10-5.
2003: Ishimitsu Toshihiko; Tsukada Kohju; Minami Junichi; Ono Hidehiko; Ohrui Masami; Hino Jun; Kangawa Kenji; Matsuoka Hiroaki
Microsatellite DNA polymorphism of human adrenomedullin gene in type 2 diabetic patients with renal failure.
Kidney international 2003;63(6):2230-5.
2003: Horio Takeshi; Tokudome Takeshi; Maki Toshiyuki; Yoshihara Fumiki; Suga Shin-Ichi; Nishikimi Toshio; Kojima Masayasu; Kawano Yuhei; Kangawa Kenji
Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts.
Endocrinology 2003;144(6):2279-84.
2003: Mondal Muhtashan S; Date Yukari; Murakami Noboru; Toshinai Koji; Shimbara Takuya; Kangawa Kenji; Nakazato Masamitsu
Neuromedin U acts in the central nervous system to inhibit gastric acid secretion via CRH system.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(6):G963-9.
2003: Sakata Ichiro; Yamazaki Mami; Inoue Kinji; Hayashi Yujiro; Kangawa Kenji; Sakai Takafumi
Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion.
Neuroscience letters 2003;342(3):183-6.
2003: Tanaka Keisuke; Minoura Hiroyuki; Isobe Tetsuya; Yonaha Hitoshi; Kawato Hiroaki; Wang Dong Fang; Yoshida Toshimichi; Kojima Masayasu; Kangawa Kenji; Toyoda Nagayasu
Ghrelin is involved in the decidualization of human endometrial stromal cells.
The Journal of clinical endocrinology and metabolism 2003;88(5):2335-40.
2003: Sugino Toshihisa; Yamaura Junji; Yamagishi Masako; Kurose Yohei; Kojima Masayasu; Kangawa Kenji; Hasegawa Yoshihisa; Terashima Yoshiaki
Involvement of cholinergic neurons in the regulation of the ghrelin secretory response to feeding in sheep.
Biochemical and biophysical research communications 2003;304(2):308-12.
2003: Masaoka Tatsuhiro; Suzuki Hidekazu; Hosoda Hiroshi; Ota Takayuki; Minegishi Yuriko; Nagata Hiroshi; Kangawa Kenji; Ishii Hiromasa
Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes.
FEBS letters 2003;541(1-3):64-8.
2003: Nagaya Noritoshi; Kangawa Kenji
Ghrelin improves left ventricular dysfunction and cardiac cachexia in heart failure.
Current opinion in pharmacology 2003;3(2):146-51.
2003: Nakahara Keiko; Hayashida Takahiro; Nakazato Masamitsu; Kojima Masayasu; Hosoda Hiroshi; Kangawa Kenji; Murakami Noboru
Effect of chronic treatments with ghrelin on milk secretion in lactating rats.
Biochemical and biophysical research communications 2003;303(3):751-5.
2003: Takeuchi Hiroto; Ohmori Koji; Kondo Isao; Oshita Akira; Shinomiya Kaori; Yu Yang; Takagi Yuichiro; Mizushige Katsufumi; Kangawa Kenji; Kohno Masakazu
Potentiation of C-type natriuretic peptide with ultrasound and microbubbles to prevent neointimal formation after vascular injury in rats.
Cardiovascular research 2003;58(1):231-8.
2003: Okimura Yasuhiko; Ukai Kiyoharu; Hosoda Hiroshi; Murata Masahiro; Iguchi Genzo; Iida Keiji; Kaji Hidesuke; Kojima Masayasu; Kangawa Kenji; Chihara Kazuo
The role of circulating ghrelin in growth hormone (GH) secretion in freely moving male rats.
Life sciences 2003;72(22):2517-24.
2003: Toshinai Koji; Date Yukari; Murakami Noboru; Shimada Mitsushi; Mondal Muhtashan S; Shimbara Takuya; Guan Jian-Lian; Wang Qing-Ping; Funahashi Hisayuki; Sakurai Takeshi; Shioda Seiji; Matsukura Shigeru; Kangawa Kenji; Nakazato Masamitsu
Ghrelin-induced food intake is mediated via the orexin pathway.
Endocrinology 2003;144(4):1506-12.
2003: Katafuchi Takeshi; Kikumoto Katsuro; Hamano Kazumasa; Kangawa Kenji; Matsuo Hisayuki; Minamino Naoto
Calcitonin receptor-stimulating peptide, a new member of the calcitonin gene-related peptide family. Its isolation from porcine brain, structure, tissue distribution, and biological activity.
The Journal of biological chemistry 2003;278(14):12046-54.
2003: Kaiya H; Kojima M; Hosoda H; Riley L G; Hirano T; Grau E G; Kangawa K
Amidated fish ghrelin: purification, cDNA cloning in the Japanese eel and its biological activity.
The Journal of endocrinology 2003;176(3):415-23.
2003: Nishikimi Toshio; Tadokoro Kazuyoshi; Mori Yosuke; Wang Xin; Akimoto Kazumi; Yoshihara Fumiki; Minamino Naoto; Kangawa Kenji; Matsuoka Hiroaki
Ventricular adrenomedullin system in the transition from LVH to heart failure in rats.
Hypertension 2003;41(3):512-8.
2003: Shimada Mitsushi; Date Yukari; Mondal Muhtashan S; Toshinai Koji; Shimbara Takuya; Fukunaga Kyoko; Murakami Noboru; Miyazato Mikiya; Kangawa Kenji; Yoshimatsu Hironobu; Matsuo Hisayuki; Nakazato Masamitsu
Somatostatin suppresses ghrelin secretion from the rat stomach.
Biochemical and biophysical research communications 2003;302(3):520-5.
2003: Wada Reiko; Sakata Ichiro; Kaiya Hiroyuki; Nakamura Kazuaki; Hayashi Yujiro; Kangawa Kenji; Sakai Takafumi
Existence of ghrelin-immunopositive and -expressing cells in the proventriculus of the hatching and adult chicken.
Regulatory peptides 2003;111(1-3):123-8.
2003: Choi Kichoon; Roh Sang-Gun; Hong Yeon-Hee; Shrestha Yogendra B; Hishikawa Daisuke; Chen Chen; Kojima Masayasu; Kangawa Kenji; Sasaki Shin-Ichi
The role of ghrelin and growth hormone secretagogues receptor on rat adipogenesis.
Endocrinology 2003;144(3):754-9.
2003: Nagaya Noritoshi; Miyatake Kunio; Kyotani Shingo; Nishikimi Toshio; Nakanishi Norifumi; Kangawa Kenji
Pulmonary vasodilator response to adrenomedullin in patients with pulmonary hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26 Suppl():S141-6.
2003: Nishikimi Toshio; Yoshihara Fumiki; Mori Yosuke; Kangawa Kenji; Matsuoka Hiroaki
Cardioprotective effect of adrenomedullin in heart failure.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26 Suppl():S121-7.
2003: Okumura Hiroyuki; Nagaya Noritoshi; Kangawa Kenji
Adrenomedullin infusion during ischemia/reperfusion attenuates left ventricular remodeling and myocardial fibrosis in rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26 Suppl():S99-104.
2003: Nishimatsu Hiroaki; Hirata Yasunobu; Shindo Takayuki; Kurihara Hiroki; Suzuki Etsu; Sata Masataka; Satonaka Hiroshi; Takeda Ryo; Nagata Daisuke; Kakoki Masao; Hayakawa Hiroshi; Kangawa Kenji; Matsuo Hisayuki; Kitamura Tadaichi; Nagai Ryozo
Endothelial responses of the aorta from adrenomedullin transgenic mice and knockout mice.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26 Suppl():S79-84.
2003: Yamaga Junichi; Hashida Seiichi; Kitamura Kazuo; Tokashiki Mariko; Aoki Toshihiro; Inatsu Haruhiko; Ishikawa Naoto; Kangawa Kenji; Morishita Kazuhiro; Eto Tanenao
Direct measurement of glycine-extended adrenomedullin in plasma and tissue using an ultrasensitive immune complex transfer enzyme immunoassay in rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26 Suppl():S45-53.
2003: Shimizu Yoshito; Nagaya Noritoshi; Isobe Takeshi; Imazu Michinori; Okumura Hiroyuki; Hosoda Hiroshi; Kojima Masayasu; Kangawa Kenji; Kohno Nobuoki
Increased plasma ghrelin level in lung cancer cachexia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(2):774-8.
2003: Makino Ikuko; Makino Yasuo; Yoshihara Fumiki; Nishikimi Toshio; Kawarabayashi Tatsuhiko; Kangawa Kenji; Shibata Kazuhiko
Decreased mature adrenomedullin levels in feto-maternal tissues of pregnant women with histologic chorioamnionitis.
Biochemical and biophysical research communications 2003;301(2):437-42.
2003: Hanada Takeshi; Toshinai Koji; Kajimura Naoko; Nara-Ashizawa Noriko; Tsukada Toshihiko; Hayashi Yujiro; Osuye Kazuhiro; Kangawa Kenji; Matsukura Shigeru; Nakazato Masamitsu
Anti-cachectic effect of ghrelin in nude mice bearing human melanoma cells.
Biochemical and biophysical research communications 2003;301(2):275-9.
2003: Suga Shin-Ichi; Yasui Naomi; Yoshihara Fumiki; Horio Takeshi; Kawano Yuhei; Kangawa Kenji; Johnson Richard J
Endothelin a receptor blockade and endothelin B receptor blockade improve hypokalemic nephropathy by different mechanisms.
Journal of the American Society of Nephrology : JASN 2003;14(2):397-406.
2003: Hosoda Hiroshi; Kojima Masayasu; Mizushima Tsunekazu; Shimizu Shigeomi; Kangawa Kenji
Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing.
The Journal of biological chemistry 2003;278(1):64-70.
2002: Hosoda Hiroshi; Kojima Masayasu; Kangawa Kenji
Ghrelin and the regulation of food intake and energy balance.
Molecular interventions 2002;2(8):494-503.
2002: Kojima Masayasu; Kangawa Kenji
Ghrelin, an orexigenic signaling molecule from the gastrointestinal tract.
Current opinion in pharmacology 2002;2(6):665-8.
2002: Ikezaki Ayako; Hosoda Hiroshi; Ito Keiko; Iwama Saika; Miura Naoko; Matsuoka Hisafumi; Kondo Chisato; Kojima Masayasu; Kangawa Kenji; Sugihara Shigetaka
Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents.
Diabetes 2002;51(12):3408-11.
2002: Nakamura Ryosai; Kato Johji; Kitamura Kazuo; Onitsuka Hisamitsu; Imamura Takuroh; Marutsuka Kousuke; Asada Yujiro; Kangawa Kenji; Eto Tanenao
Beneficial effects of adrenomedullin on left ventricular remodeling after myocardial infarction in rats.
Cardiovascular research 2002;56(3):373-80.
2002: Kato Johji; Kitamura Kazuo; Uemura Tomohiko; Kuwasako Kenji; Kita Toshihiro; Kangawa Kenji; Eto Tanenao
Plasma levels of adrenomedullin and atrial and brain natriuretic peptides in the general population: their relations to age and pulse pressure.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(6):887-92.
2002: Minami Junichi; Nishikimi Toshio; Todoroki Masakatsu; Kashiwakura Chieko; Yagi Hiroshi; Ono Hidehiko; Horinaka Shigeo; Ishimitsu Toshihiko; Kangawa Kenji; Matsuoka Hiroaki
Source of plasma adrenomedullin in patients with pheochromocytoma.
American journal of hypertension 2002;15(11):994-7.
2002: Sugino Toshihisa; Yamaura Junji; Yamagishi Masako; Ogura Atsushi; Hayashi Reiko; Kurose Youhei; Kojima Masayasu; Kangawa Kenji; Hasegawa Yoshihisa; Terashima Yoshiaki
A transient surge of ghrelin secretion before feeding is modified by different feeding regimens in sheep.
Biochemical and biophysical research communications 2002;298(5):785-8.
2002: Iwakura Hiroshi; Hosoda Kiminori; Doi Ryuichiro; Komoto Izumi; Nishimura Haruo; Son Choel; Fujikura Junji; Tomita Tsutomu; Takaya Kazuhiko; Ogawa Yoshihiro; Hayashi Tatsuya; Inoue Gen; Akamizu Takashi; Hosoda Hiroshi; Kojima Masayasu; Kangawa Kenji; Imamura Masayuki; Nakao Kazuwa
Ghrelin expression in islet cell tumors: augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I.
The Journal of clinical endocrinology and metabolism 2002;87(11):4885-8.
2002: Sano Hirofumi; Miyata Atsuro; Horio Takeshi; Nishikimi Toshio; Matsuo Hisayuki; Kangawa Kenji
The effect of pituitary adenylate cyclase activating polypeptide on cultured rat cardiocytes as a cardioprotective factor.
Regulatory peptides 2002;109(1-3):107-13.
2002: Yoshimoto Akihiro; Mori Kiyoshi; Sugawara Akira; Mukoyama Masashi; Yahata Kensei; Suganami Takayoshi; Takaya Kazuhiko; Hosoda Hiroshi; Kojima Masayasu; Kangawa Kenji; Nakao Kazuwa
Plasma ghrelin and desacyl ghrelin concentrations in renal failure.
Journal of the American Society of Nephrology : JASN 2002;13(11):2748-52.
2002: Saito Ei-suke; Kaiya Hiroyuki; Takagi Tomo; Yamasaki Izumi; Denbow D Michael; Kangawa Kenji; Furuse Mitsuhiro
Chicken ghrelin and growth hormone-releasing peptide-2 inhibit food intake of neonatal chicks.
European journal of pharmacology 2002;453(1):75-9.
2002: Date Yukari; Murakami Noboru; Toshinai Koji; Matsukura Shigeru; Niijima Akira; Matsuo Hisayuki; Kangawa Kenji; Nakazato Masamitsu
The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats.
Gastroenterology 2002;123(4):1120-8.
2002: Nørrelund Helene; Hansen Troels K; Ørskov Hans; Hosoda Hiroshi; Kojima Masayasu; Kangawa Kenji; Weeke Jørgen; Møller Niels; Christiansen Jens S; Jørgensen Jens Otto L
Ghrelin immunoreactivity in human plasma is suppressed by somatostatin.
Clinical endocrinology 2002;57(4):539-46.
2002: Unniappan Surajlal; Lin Xinwei; Cervini Laura; Rivier Jean; Kaiya Hiroyuki; Kangawa Kenji; Peter Richard E
Goldfish ghrelin: molecular characterization of the complementary deoxyribonucleic acid, partial gene structure and evidence for its stimulatory role in food intake.
Endocrinology 2002;143(10):4143-6.
2002: Sakata I; Tanaka T; Matsubara M; Yamazaki M; Tani S; Hayashi Y; Kangawa K; Sakai T
Postnatal changes in ghrelin mRNA expression and in ghrelin-producing cells in the rat stomach.
The Journal of endocrinology 2002;174(3):463-71.
2002: Tokudome Takeshi; Horio Takeshi; Yoshihara Fumiki; Suga Shin-Ichi; Kawano Yuhei; Kohno Masakazu; Kangawa Kenji
Adrenomedullin inhibits doxorubicin-induced cultured rat cardiac myocyte apoptosis via a cAMP-dependent mechanism.
Endocrinology 2002;143(9):3515-21.
2002: Kaiya Hiroyuki; Van Der Geyten Serge; Kojima Masayasu; Hosoda Hiroshi; Kitajima Yasuo; Matsumoto Masaru; Geelissen Sofie; Darras Veerle M; Kangawa Kenji
Chicken ghrelin: purification, cDNA cloning, and biological activity.
Endocrinology 2002;143(9):3454-63.
2002: Ariyasu Hiroyuki; Takaya Kazuhiko; Hosoda Hiroshi; Iwakura Hiroshi; Ebihara Ken; Mori Kiyoshi; Ogawa Yoshihiro; Hosoda Kiminori; Akamizu Takashi; Kojima Masayasu; Kangawa Kenji; Nakao Kazuwa
Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin.
Endocrinology 2002;143(9):3341-50.
2002: Nakagawa Eiichiro; Nagaya Noritoshi; Okumura Hiroyuki; Enomoto Mitsunobu; Oya Hideo; Ono Fumiaki; Hosoda Hiroshi; Kojima Masayasu; Kangawa Kenji
Hyperglycaemia suppresses the secretion of ghrelin, a novel growth-hormone-releasing peptide: responses to the intravenous and oral administration of glucose.
Clinical science (London, England : 1979) 2002;103(3):325-8.
2002: Murakami N; Hayashida T; Kuroiwa T; Nakahara K; Ida T; Mondal M S; Nakazato M; Kojima M; Kangawa K
Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats.
The Journal of endocrinology 2002;174(2):283-8.
2002: Imai Yasushi; Shindo Takayuki; Maemura Koji; Sata Masataka; Saito Yuichiro; Kurihara Yukiko; Akishita Masahiro; Osuga Junichi; Ishibashi Shun; Tobe Kazuyuki; Morita Hiroyuki; Oh-hashi Yoshio; Suzuki Toru; Maekawa Hiromitsu; Kangawa Kenji; Minamino Naoto; Yazaki Yoshio; Nagai Ryozo; Kurihara Hiroki
Resistance to neointimal hyperplasia and fatty streak formation in mice with adrenomedullin overexpression.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(8):1310-5.
2002: Galas Ludovic; Chartrel Nicolas; Kojima Masayasu; Kangawa Kenji; Vaudry Hubert
Immunohistochemical localization and biochemical characterization of ghrelin in the brain and stomach of the frog Rana esculenta.
The Journal of comparative neurology 2002;450(1):34-44.
2002: Sugino T; Hasegawa Y; Kikkawa Y; Yamaura J; Yamagishi M; Kurose Y; Kojima M; Kangawa K; Terashima Y
A transient ghrelin surge occurs just before feeding in a scheduled meal-fed sheep.
Biochemical and biophysical research communications 2002;295(2):255-60.
2002: Yoshihara Fumiki; Kojima Masayasu; Hosoda Hiroshi; Nakazato Masamitsu; Kangawa Kenji
Ghrelin: a novel peptide for growth hormone release and feeding regulation.
Current opinion in clinical nutrition and metabolic care 2002;5(4):391-5.
2002: Mori Yosuke; Nishikimi Toshio; Kobayashi Naohiko; Ono Hidehiko; Kangawa Kenji; Matsuoka Hiroaki
Long-term adrenomedullin infusion improves survival in malignant hypertensive rats.
Hypertension 2002;40(1):107-13.
2002: Dall Rolf; Kanaley Jill; Hansen Troels Krarup; Møller Niels; Christiansen Jens S; Hosoda Hiroshi; Kangawa Kenji; Jørgensen Jens O L
Plasma ghrelin levels during exercise in healthy subjects and in growth hormone-deficient patients.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(1):65-70.
2002: Nishikimi Toshio; Mori Yosuke; Kobayashi Naohiko; Tadokoro Kazuyoshi; Wang Xin; Akimoto Kazumi; Yoshihara Fumiki; Kangawa Kenji; Matsuoka Hiroaki
Renoprotective effect of chronic adrenomedullin infusion in Dahl salt-sensitive rats.
Hypertension 2002;39(6):1077-82.
2002: Nishikimi Toshio; Shibasaki Ikuko; Iida Hiroshi; Asakawa Hiroshi; Matsushita Yasushi; Mori Hideaki; Mochizuki Yoshihiko; Okamura Yoshitaka; Horinaka Shigeo; Kangawa Kenji; Shimada Koichiro; Matsuoka Hiroaki
Molecular forms of adrenomedullin in pericardial fluid and plasma in patients with ischaemic heart disease.
Clinical science (London, England : 1979) 2002;102(6):669-77.
2002: Uemura Tomohiko; Kato Johji; Kuwasako Kenji; Kitamura Kazuo; Kangawa Kenji; Eto Tanenao
Aldosterone augments adrenomedullin production without stimulating pro-adrenomedullin N-terminal 20 peptide secretion in vascular smooth muscle cells.
Journal of hypertension 2002;20(6):1209-14.
2002: Yasuda Satoshi; Kanna Masahiko; Sakuragi Satoru; Kojima Sunao; Nakayama Yasuhide; Miyazaki Shunichi; Matsuda Takehisa; Kangawa Kenji; Nonogi Hiroshi
Local delivery of single low-dose of C-type natriuretic peptide, an endogenous vascular modulator, inhibits neointimal hyperplasia in a balloon-injured rabbit iliac artery model.
Journal of cardiovascular pharmacology 2002;39(6):784-8.
2002: Okumura Hiroyuki; Nagaya Noritoshi; Enomoto Mitsunobu; Nakagawa Eiichiroh; Oya Hideo; Kangawa Kenji
Vasodilatory effect of ghrelin, an endogenous peptide from the stomach.
Journal of cardiovascular pharmacology 2002;39(6):779-83.
2002: Hayashida T; Nakahara K; Mondal M S; Date Y; Nakazato M; Kojima M; Kangawa K; Murakami N
Ghrelin in neonatal rats: distribution in stomach and its possible role.
The Journal of endocrinology 2002;173(2):239-45.
2002: Nagaya Noritoshi; Goto Yoichi; Satoh Toru; Sumida Hitoshi; Kojima Sunao; Miyatake Kunio; Kangawa Kenji
Intravenous adrenomedullin in myocardial function and energy metabolism in patients after myocardial infarction.
Journal of cardiovascular pharmacology 2002;39(5):754-60.
2002: Kis B; Kaiya H; Nishi R; Deli M A; Abrahám C S; Yanagita T; Isse T; Gotoh S; Kobayashi H; Wada A; Niwa M; Kangawa K; Greenwood J; Yamashita H; Ueta Y
Cerebral endothelial cells are a major source of adrenomedullin.
Journal of neuroendocrinology 2002;14(4):283-93.
2002: Nishimatsu Hiroaki; Hirata Yasunobu; Shindo Takayuki; Kurihara Hiroki; Kakoki Masao; Nagata Daisuke; Hayakawa Hiroshi; Satonaka Hiroshi; Sata Masataka; Tojo Akihiro; Suzuki Etsu; Kangawa Kenji; Matsuo Hisayuki; Kitamura Tadaichi; Nagai Ryozo
Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene.
Circulation research 2002;90(6):657-63.
2002: Kitamura Kazuo; Kangawa Kenji; Eto Tanenao
Adrenomedullin and PAMP: discovery, structures, and cardiovascular functions.
Microscopy research and technique 2002;57(1):3-13.
2002: Chu Chunping; Jin Qinghua; Kunitake Takato; Kato Kazuo; Nabekura Takashi; Nakazato Masamitsu; Kangawa Kenji; Kannan Hiroshi
Cardiovascular actions of central neuromedin U in conscious rats.
Regulatory peptides 2002;105(1):29-34.
2002: Makino Yasuo; Hosoda Hiroshi; Shibata Kazuhiko; Makino Ikuko; Kojima Masayasu; Kangawa Kenji; Kawarabayashi Tatsuhiko
Alteration of plasma ghrelin levels associated with the blood pressure in pregnancy.
Hypertension 2002;39(3):781-4.
2002: Lu S; Guan J-L; Wang Q-P; Uehara K; Yamada S; Goto N; Date Y; Nakazato M; Kojima M; Kangawa K; Shioda S
Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus.
Neuroscience letters 2002;321(3):157-60.
2002: Tanikawa Naomi; Ohmiya Yoshihiro; Ohkubo Hiroaki; Hashimoto Katsuyuki; Kangawa Kenji; Kojima Masami; Ito Seiji; Watanabe Kikuko
Identification and characterization of a novel type of membrane-associated prostaglandin E synthase.
Biochemical and biophysical research communications 2002;291(4):884-9.
2002: Tambara K; Fujita M; Nagaya N; Miyamoto S; Iwakura A; Doi K; Sakaguchi G; Nishimura K; Kangawa K; Komeda M
Increased pericardial fluid concentrations of the mature form of adrenomedullin in patients with cardiac remodelling.
Heart (British Cardiac Society) 2002;87(3):242-6.
2002: Sakata Ichiro; Nakamura Kazuaki; Yamazaki Mami; Matsubara Maki; Hayashi Yuijiro; Kangawa Kenji; Sakai Takafumi
Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract.
Peptides 2002;23(3):531-6.
2002: Hansen Troels Krarup; Dall Rolf; Hosoda Hiroshi; Kojima Masayasu; Kangawa Kenji; Christiansen Jens Sandahl; Jørgensen Jens Otto Lunde
Weight loss increases circulating levels of ghrelin in human obesity.
Clinical endocrinology 2002;56(2):203-6.
2002: Yamazaki M; Nakamura K; Kobayashi H; Matsubara M; Hayashi Y; Kangawa K; Sakai T
Regulational effect of ghrelin on growth hormone secretion from perifused rat anterior pituitary cells.
Journal of neuroendocrinology 2002;14(2):156-62.
2002: Yoshihara Fumiki; Horio Takeshi; Nishikimi Toshio; Matsuo Hisayuki; Kangawa Kenji
Possible involvement of oxidative stress in hypoxia-induced adrenomedullin secretion in cultured rat cardiomyocytes.
European journal of pharmacology 2002;436(1-2):1-6.
2002: Murata Masahiro; Okimura Yasuhiko; Iida Keiji; Matsumoto Michihiro; Sowa Hideaki; Kaji Hidesuke; Kojima Masayasu; Kangawa Kenji; Chihara Kazuo
Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells.
The Journal of biological chemistry 2002;277(7):5667-74.
2002: Shiiya Tomomi; Nakazato Masamitsu; Mizuta Masanari; Date Yukari; Mondal Muhtashan S; Tanaka Muneki; Nozoe Shin-Ichi; Hosoda Hiroshi; Kangawa Kenji; Matsukura Shigeru
Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion.
The Journal of clinical endocrinology and metabolism 2002;87(1):240-4.
2002: Yoshihara Fumiki; Nishikimi Toshio; Sasako Yoshikado; Hino Jun; Kobayashi Junjiro; Minatoya Kenji; Bando Ko; Kosakai Yoshio; Horio Takeshi; Suga Shin-ichi; Kawano Yuhei; Matsuoka Hiroaki; Yutani Chikao; Matsuo Hisayuki; Kitamura Soichiro; Ohe Tohru; Kangawa Kenji
Plasma atrial natriuretic peptide concentration inversely correlates with left atrial collagen volume fraction in patients with atrial fibrillation: plasma ANP as a possible biochemical marker to predict the outcome of the maze procedure.
Journal of the American College of Cardiology 2002;39(2):288-94.
2002: Shimosawa Tatsuo; Shibagaki Yugo; Ishibashi Kotaro; Kitamura Kazuo; Kangawa Kenji; Kato Shigeaki; Ando Katsuyuki; Fujita Toshiro
Adrenomedullin, an endogenous peptide, counteracts cardiovascular damage.
Circulation 2002;105(1):106-11.
2002: Date Yukari; Nakazato Masamitsu; Hashiguchi Suzuko; Dezaki Katsuya; Mondal Muhtashan S; Hosoda Hiroshi; Kojima Masayasu; Kangawa Kenji; Arima Terukatsu; Matsuo Hisayuki; Yada Toshihiko; Matsukura Shigeru
Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion.
Diabetes 2002;51(1):124-9.
2001: Kis B; Deli M A; Kobayashi H; Abrahám C S; Yanagita T; Kaiya H; Isse T; Nishi R; Gotoh S; Kangawa K; Wada A; Greenwood J; Niwa M; Yamashita H; Ueta Y
Adrenomedullin regulates blood-brain barrier functions in vitro.
Neuroreport 2001;12(18):4139-42.
2001: Nagaya N; Miyatake K; Uematsu M; Oya H; Shimizu W; Hosoda H; Kojima M; Nakanishi N; Mori H; Kangawa K
Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure.
The Journal of clinical endocrinology and metabolism 2001;86(12):5854-9.
2001: Nishikimi T; Yoshihara F; Kanazawa A; Okano I; Horio T; Nagaya N; Yutani C; Matsuo H; Matsuoka H; Kangawa K
Role of increased circulating and renal adrenomedullin in rats with malignant hypertension.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(6):R2079-87.
2001: Nishikimi T; Junichi M; Yasu T; Takeshi S; Kangawa K; Matsuoka H
Two molecular forms of plasma adrenomedullin during tilt test in healthy subjects.
Peptides 2001;22(11):1867-72.
2001: Ueta Y; Hara Y; Kitamura K; Kangawa K; Eto T; Hattori Y; Yamashita H
Action sites of adrenomedullin in the rat brain: functional mapping by Fos expression.
Peptides 2001;22(11):1817-24.
2001: Ishimitsu T; Hosoya K; Tsukada K; Minami J; Ono H; Ohrui M; Hino J; Kangawa K; Matsuoka H
Chromosomal sublocalization and microsatellite DNA polymorphism of human adrenomedullin gene.
Peptides 2001;22(11):1739-44.
2001: Kitamura K; Matsui E; Kato J; Katoh F; Kita T; Tsuji T; Kangawa K; Eto T
Adrenomedullin (11-26): a novel endogenous hypertensive peptide isolated from bovine adrenal medulla.
Peptides 2001;22(11):1713-8.
2001: Makino I; Honda K; Makino Y; Okano I; Kangawa K; Kamiya H; Shibata K; Kawarabayashi T
Phenotypic changes of adrenomedullin receptor components, RAMP2, and CRLR mRNA expression in cultured rat vascular smooth muscle cells.
Biochemical and biophysical research communications 2001;288(3):515-20.
2001: Kaiya H; Kojima M; Hosoda H; Koda A; Yamamoto K; Kitajima Y; Matsumoto M; Minamitake Y; Kikuyama S; Kangawa K
Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue.
The Journal of biological chemistry 2001;276(44):40441-8.
2001: Nagaya N; Uematsu M; Kojima M; Date Y; Nakazato M; Okumura H; Hosoda H; Shimizu W; Yamagishi M; Oya H; Koh H; Yutani C; Kangawa K
Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors.
Circulation 2001;104(17):2034-8.
2001: Shindo T; Kurihara Y; Nishimatsu H; Moriyama N; Kakoki M; Wang Y; Imai Y; Ebihara A; Kuwaki T; Ju K H; Minamino N; Kangawa K; Ishikawa T; Fukuda M; Akimoto Y; Kawakami H; Imai T; Morita H; Yazaki Y; Nagai R; Hirata Y; Kurihara H
Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.
Circulation 2001;104(16):1964-71.
2001: Makino Y; Shibata K; Makino I; Kangawa K; Kawarabayashi T
Alteration of the adrenomedullin receptor components gene expression associated with the blood pressure in pregnancy-induced hypertension.
The Journal of clinical endocrinology and metabolism 2001;86(10):5079-82.
2001: Kanamoto N; Akamizu T; Hosoda H; Hataya Y; Ariyasu H; Takaya K; Hosoda K; Saijo M; Moriyama K; Shimatsu A; Kojima M; Kangawa K; Nakao K
Substantial production of ghrelin by a human medullary thyroid carcinoma cell line.
The Journal of clinical endocrinology and metabolism 2001;86(10):4984-90.
2001: Ariyasu H; Takaya K; Tagami T; Ogawa Y; Hosoda K; Akamizu T; Suda M; Koh T; Natsui K; Toyooka S; Shirakami G; Usui T; Shimatsu A; Doi K; Hosoda H; Kojima M; Kangawa K; Nakao K
Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans.
The Journal of clinical endocrinology and metabolism 2001;86(10):4753-8.
2001: Nagaya N; Uematsu M; Kojima M; Ikeda Y; Yoshihara F; Shimizu W; Hosoda H; Hirota Y; Ishida H; Mori H; Kangawa K
Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure.
Circulation 2001;104(12):1430-5.
2001: Hataya Y; Akamizu T; Takaya K; Kanamoto N; Ariyasu H; Saijo M; Moriyama K; Shimatsu A; Kojima M; Kangawa K; Nakao K
A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans.
The Journal of clinical endocrinology and metabolism 2001;86(9):4552.
2001: Sekiguchi T; Miyamoto K; Mizutani T; Yamada K; Yazawa T; Yoshino M; Minegishi T; Takei Y; Kangawa K; Minamino N; Saito Y; Kojima M
Molecular cloning of natriuretic peptide receptor A from bullfrog (Rana catesbeiana) brain and its functional expression.
Gene 2001;273(2):251-7.
2001: Hayashida T; Murakami K; Mogi K; Nishihara M; Nakazato M; Mondal M S; Horii Y; Kojima M; Kangawa K; Murakami N
Ghrelin in domestic animals: distribution in stomach and its possible role.
Domestic animal endocrinology 2001;21(1):17-24.
2001: Kojima M; Kangawa K
[Ghrelin: a novel growth-hormone releasing peptide]
Nippon rinsho. Japanese journal of clinical medicine 2001;59(7):1400-7.
2001: Ishimitsu T; Hosoya K; Tsukada K; Minami J; Futoh Y; Ono H; Ohrui M; Hino J; Kangawa K; Matsuoka H
Microsatellite DNA polymorphism of human adrenomedullin gene in normotensive subjects and patients with essential hypertension.
Hypertension 2001;38(1):9-12.
2001: Nishimatsu H; Suzuki E; Nagata D; Moriyama N; Satonaka H; Walsh K; Sata M; Kangawa K; Matsuo H; Goto A; Kitamura T; Hirata Y
Adrenomedullin induces endothelium-dependent vasorelaxation via the phosphatidylinositol 3-kinase/Akt-dependent pathway in rat aorta.
Circulation research 2001;89(1):63-70.
2001: Tsuruda T; Kato J; Kitamura K; Kuwasako K; Imamura T; Koiwaya Y; Kangawa K; Eto T
Secretion of proadrenomedullin N-terminal 20 peptide from cultured neonatal rat cardiac cells.
Life sciences 2001;69(2):239-45.
2001: Kubo A; Isumi Y; Ishizaka Y; Tomoda Y; Kangawa K; Dohi K; Matsuo H; Minamino N
C-type natriuretic peptide is synthesized and secreted from leukemia cell lines, peripheral blood cells, and peritoneal macrophages.
Experimental hematology 2001;29(5):609-15.
2001: Nagaya N; Kojima M; Uematsu M; Yamagishi M; Hosoda H; Oya H; Hayashi Y; Kangawa K
Hemodynamic and hormonal effects of human ghrelin in healthy volunteers.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(5):R1483-7.
2001: Nishikimi T; Horio T; Kohmoto Y; Yoshihara F; Nagaya N; Inenaga T; Saito M; Teranishi M; Nakamura M; Ohrui M; Kawano Y; Matsuo H; Ishimitsu T; Takishita S; Matsuoka H; Kangawa K
Molecular forms of plasma and urinary adrenomedullin in normal, essential hypertension and chronic renal failure.
Journal of hypertension 2001;19(4):765-73.
2001: Tsuruda T; Kato J; Kitamura K; Mishima K; Imamura T; Koiwaya Y; Kangawa K; Eto T
Roles of protein kinase C and Ca2+-dependent signaling in angiotensin II-induced adrenomedullin production in rat cardiac myocytes.
Journal of hypertension 2001;19(4):757-63.
2001: Toshinai K; Mondal M S; Nakazato M; Date Y; Murakami N; Kojima M; Kangawa K; Matsukura S
Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration.
Biochemical and biophysical research communications 2001;281(5):1220-5.
2001: Tomoda Y; Kikumoto K; Isumi Y; Katafuchi T; Tanaka A; Kangawa K; Dohi K; Minamino N
Cardiac fibroblasts are major production and target cells of adrenomedullin in the heart in vitro.
Cardiovascular research 2001;49(4):721-30.
2001: Shintani M; Ogawa Y; Ebihara K; Aizawa-Abe M; Miyanaga F; Takaya K; Hayashi T; Inoue G; Hosoda K; Kojima M; Kangawa K; Nakao K
Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway.
Diabetes 2001;50(2):227-32.
2001: Nagaya N; Nishikimi T; Uematsu M; Satoh T; Kyotani S; Sakamaki F; Kakishita M; Fukushima K; Okano Y; Nakanishi N; Miyatake K; Kangawa K
[Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension]
Journal of cardiology 2001;37(2):110-1.
2001: Yoshihara F; Nishikimi T; Okano I; Horio T; Yutani C; Matsuo H; Takishita S; Ohe T; Kangawa K
Alterations of intrarenal adrenomedullin and its receptor system in heart failure rats.
Hypertension 2001;37(2):216-22.
2001: Nakazato M; Murakami N; Date Y; Kojima M; Matsuo H; Kangawa K; Matsukura S
A role for ghrelin in the central regulation of feeding.
Nature 2001;409(6817):194-8.
2001: Date Y; Nakazato M; Murakami N; Kojima M; Kangawa K; Matsukura S
Ghrelin acts in the central nervous system to stimulate gastric acid secretion.
Biochemical and biophysical research communications 2001;280(3):904-7.
2001: Sugo S; Minamino N; Shoji H; Isumi Y; Nakao K; Kangawa K; Matsuo H
Regulation of endothelin-1 production in cultured rat vascular smooth muscle cells.
Journal of cardiovascular pharmacology 2001;37(1):25-40.
2001: Asakawa H; Nishikimi T; Suzuki T; Hara S; Tsubokou Y; Yagi H; Yabe A; Tsuchiya N; Horinaka S; Kangawa K; Matsuoka H
Elevation of two molecular forms of adrenomedullin in plasma and urine in patients with acute myocardial infarction treated with early coronary angioplasty.
Clinical science (London, England : 1979) 2001;100(1):117-26.
2001: Nishikimi T; Nagata S; Sasaki T; Yoshihara F; Nagaya N; Horio T; Matsuo H; Matsuoka H; Kangawa K
The active molecular form of plasma adrenomedullin is extracted in the pulmonary circulation in patients with mitral stenosis: possible role of adrenomedullin in pulmonary hypertension.
Clinical science (London, England : 1979) 2001;100(1):61-6.
2001: Kojima M; Hosoda H; Kangawa K
Purification and distribution of ghrelin: the natural endogenous ligand for the growth hormone secretagogue receptor.
Hormone research 2001;56 Suppl 1():93-7.
2000: Hosoda H; Kojima M; Matsuo H; Kangawa K
Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue.
Biochemical and biophysical research communications 2000;279(3):909-13.
2000: Takaya K; Ariyasu H; Kanamoto N; Iwakura H; Yoshimoto A; Harada M; Mori K; Komatsu Y; Usui T; Shimatsu A; Ogawa Y; Hosoda K; Akamizu T; Kojima M; Kangawa K; Nakao K
Ghrelin strongly stimulates growth hormone release in humans.
The Journal of clinical endocrinology and metabolism 2000;85(12):4908-11.
2000: Mori K; Yoshimoto A; Takaya K; Hosoda K; Ariyasu H; Yahata K; Mukoyama M; Sugawara A; Hosoda H; Kojima M; Kangawa K; Nakao K
Kidney produces a novel acylated peptide, ghrelin.
FEBS letters 2000;486(3):213-6.
2000: Nishikimi T; Miyata A; Horio T; Yoshihara F; Nagaya N; Takishita S; Yutani C; Matsuo H; Matsuoka H; Kangawa K
Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart.
American journal of physiology. Heart and circulatory physiology 2000;279(6):H3031-9.
2000: Nagaya N; Nishikimi T; Uematsu M; Satoh T; Oya H; Kyotani S; Sakamaki F; Ueno K; Nakanishi N; Miyatake K; Kangawa K
Haemodynamic and hormonal effects of adrenomedullin in patients with pulmonary hypertension.
Heart (British Cardiac Society) 2000;84(6):653-8.
2000: Date Y; Kojima M; Hosoda H; Sawaguchi A; Mondal M S; Suganuma T; Matsukura S; Kangawa K; Nakazato M
Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.
Endocrinology 2000;141(11):4255-61.
2000: Maki T; Horio T; Yoshihara F; Suga S; Takeo S; Matsuo H; Kangawa K
Effect of neutral endopeptidase inhibitor on endogenous atrial natriuretic peptide as a paracrine factor in cultured cardiac fibroblasts.
British journal of pharmacology 2000;131(6):1204-10.
2000: Nakazato M; Hanada R; Murakami N; Date Y; Mondal M S; Kojima M; Yoshimatsu H; Kangawa K; Matsukura S
Central effects of neuromedin U in the regulation of energy homeostasis.
Biochemical and biophysical research communications 2000;277(1):191-4.
2000: Kojima M; Haruno R; Nakazato M; Date Y; Murakami N; Hanada R; Matsuo H; Kangawa K
Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3).
Biochemical and biophysical research communications 2000;276(2):435-8.
2000: Nishikimi T; Matsuoka H; Shimada K; Matsuo H; Kangawa K
Production and clearance sites of two molecular forms of adrenomedullin in human plasma.
American journal of hypertension 2000;13(9):1032-4.
2000: Date Y; Murakami N; Kojima M; Kuroiwa T; Matsukura S; Kangawa K; Nakazato M
Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats.
Biochemical and biophysical research communications 2000;275(2):477-80.
2000: Nagaya N; Nishikimi T; Uematsu M; Satoh T; Kyotani S; Sakamaki F; Kakishita M; Fukushima K; Okano Y; Nakanishi N; Miyatake K; Kangawa K
Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension.
Circulation 2000;102(8):865-70.
2000: Watanabe R; Murakami Y; Marmor M D; Inoue N; Maeda Y; Hino J; Kangawa K; Julius M; Kinoshita T
Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.
The EMBO journal 2000;19(16):4402-11.
2000: Sata M; Kakoki M; Nagata D; Nishimatsu H; Suzuki E; Aoyagi T; Sugiura S; Kojima H; Nagano T; Kangawa K; Matsuo H; Omata M; Nagai R; Hirata Y
Adrenomedullin and nitric oxide inhibit human endothelial cell apoptosis via a cyclic GMP-independent mechanism.
Hypertension 2000;36(1):83-8.
2000: Abe K; Minegishi T; Ibuki Y; Kojima M; Kangawa K
Expression of adrenomedullin in the human corpus luteum.
Fertility and sterility 2000;74(1):141-5.
2000: Kubo A; Nishitani Y; Minamino N; Kikumoto K; Kurioka H; Nishino T; Iwano M; Shiiki H; Kangawa K; Dohi K
Adrenomedullin gene transcription is decreased in peripheral blood mononuclear cells of patients with IgA nephropathy.
Nephron 2000;85(3):201-6.
2000: Hosoda H; Kojima M; Matsuo H; Kangawa K
Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor.
The Journal of biological chemistry 2000;275(29):21995-2000.
2000: Tsuruda T; Kato J; Kitamura K; Imamura T; Koiwaya Y; Kangawa K; Komuro I; Yazaki Y; Eto T
Enhanced adrenomedullin production by mechanical stretching in cultured rat cardiomyocytes.
Hypertension 2000;35(6):1210-4.
2000: Maeda Y; Tanaka S; Hino J; Kangawa K; Kinoshita T
Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3.
The EMBO journal 2000;19(11):2475-82.
2000: Shindo T; Kurihara H; Maemura K; Kurihara Y; Kuwaki T; Izumida T; Minamino N; Ju K H; Morita H; Oh-hashi Y; Kumada M; Kangawa K; Nagai R; Yazaki Y
Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature.
Circulation 2000;101(19):2309-16.
2000: Nagaya N; Nishikimi T; Yoshihara F; Horio T; Morimoto A; Kangawa K
Cardiac adrenomedullin gene expression and peptide accumulation after acute myocardial infarction in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(4):R1019-26.
2000: Ueta Y; Serino R; Shibuya I; Kitamura K; Kangawa K; Russell J A; Yamashita H
A physiological role for adrenomedullin in rats; a potent hypotensive peptide in the hypothalamo-neurohypophysial system.
Experimental physiology 2000;85 Spec No():163S-169S.
2000: Date Y; Mondal M S; Matsukura S; Ueta Y; Yamashita H; Kaiya H; Kangawa K; Nakazato M
Distribution of orexin/hypocretin in the rat median eminence and pituitary.
Brain research. Molecular brain research 2000;76(1):1-6.
2000: Yoshihara F; Nishikimi T; Horio T; Yutani C; Nagaya N; Matsuo H; Ohe T; Kangawa K
Ventricular adrenomedullin concentration is a sensitive biochemical marker for volume and pressure overload in rats.
American journal of physiology. Heart and circulatory physiology 2000;278(2):H633-42.
2000: Nagaya N; Satoh T; Nishikimi T; Uematsu M; Furuichi S; Sakamaki F; Oya H; Kyotani S; Nakanishi N; Goto Y; Masuda Y; Miyatake K; Kangawa K
Hemodynamic, renal, and hormonal effects of adrenomedullin infusion in patients with congestive heart failure.
Circulation 2000;101(5):498-503.
2000: Minamino N; Kangawa K; Matsuo H
Adrenomedullin: a new peptidergic regulator of the vascular function.
Clinical hemorheology and microcirculation 2000;23(2-4):95-102.
2000: Sano H; Miyata A; Sato K; Kaiya H; Matsuo H; Kangawa K
PACAP augments nitric oxide synthesis in rat vascular smooth muscle cells stimulated with IL-1 alpha.
Annals of the New York Academy of Sciences 2000;921():415-9.
2000: Miyata A; Sano H; Li M; Matsuda Y; Kaiya H; Sato K; Matsuo H; Kangawa K; Arimura A
Genomic organization and chromosomal localization of the mouse pituitary adenylate cyclase activating polypeptide (PACAP) gene.
Annals of the New York Academy of Sciences 2000;921():344-8.
1999: Makino I; Makino Y; Kangawa K; Shibata K
Attenuated hypotensive response to proadrenomedullin N-terminal 20 peptide in pregnant rats: modulation by steroid hormones.
Peptides 1999;20(12):1521-5.
1999: Makino I; Shibata K; Makino Y; Kangawa K; Kawarabayashi T
Potentiation of the hypotensive effect of adrenomedullin in pregnant rats.
European journal of pharmacology 1999;385(2-3):129-36.
1999: Kojima M; Hosoda H; Date Y; Nakazato M; Matsuo H; Kangawa K
Ghrelin is a growth-hormone-releasing acylated peptide from stomach.
Nature 1999;402(6762):656-60.
1999: Isumi Y; Kubo A; Katafuchi T; Kangawa K; Minamino N
Adrenomedullin suppresses interleukin-1beta-induced tumor necrosis factor-alpha production in Swiss 3T3 cells.
FEBS letters 1999;463(1-2):110-4.
1999: Makino Y; Shibata K; Makino I; Ono Y; Kangawa K; Kawarabayashi T
Expression of adrenomedullin in feto-placental circulation of human normotensive pregnant women and pregnancy-induced hypertensive women.
Endocrinology 1999;140(11):5439-42.
1999: Horio T; Nishikimi T; Yoshihara F; Matsuo H; Takishita S; Kangawa K
Effects of adrenomedullin on cultured rat cardiac myocytes and fibroblasts.
European journal of pharmacology 1999;382(1):1-9.
1999: Tsuruda T; Kato J; Kitamura K; Kawamoto M; Kuwasako K; Imamura T; Koiwaya Y; Tsuji T; Kangawa K; Eto T
An autocrine or a paracrine role of adrenomedullin in modulating cardiac fibroblast growth.
Cardiovascular research 1999;43(4):958-67.
1999: Kuwasako K; Kitamura K; Kangawa K; Ishiyama Y; Kato J; Eto T
Increased plasma proadrenomedullin N-terminal 20 peptide in patients with essential hypertension.
Annals of clinical biochemistry 1999;36 ( Pt 5)():622-8.
1999: Minegishi T; Nakamura M; Abe K; Tano M; Andoh A; Yoshida M; Takagi T; Nishikimi T; Kojima M; Kangawa K
Adrenomedullin and atrial natriuretic peptide concentrations in normal pregnancy and pre-eclampsia.
Molecular human reproduction 1999;5(8):767-70.
1999: Yoshibayashi M; Kamiya T; Nishikimi T; Saito Y; Matsuo H; Kangawa K
Elevated plasma levels of adrenomedullin in congenital cyanotic heart disease.
Clinical science (London, England : 1979) 1999;96(6):543-7.
1999: Morimoto A; Nishikimi T; Yoshihara F; Horio T; Nagaya N; Matsuo H; Dohi K; Kangawa K
Ventricular adrenomedullin levels correlate with the extent of cardiac hypertrophy in rats.
Hypertension 1999;33(5):1146-52.
1999: Inoue S; Hayashi Y; Ohnishi Y; Kikumoto K; Minamino N; Kangawa K; Matsuo H; Furuya H; Kuro M
Cerebral production of adrenomedullin afer hypothermic cardiopulmonary bypass in adult cardiac surgical patients.
Anesthesia and analgesia 1999;88(5):1030-5.
1999: Date Y; Nakazato M; Yamaguchi H; Kangawa K; Kinoshita Y; Chiba T; Ueta Y; Yamashita H; Matsukura S
Enterochromaffin-like cells, a cellular source of uroguanylin in rat stomach.
Endocrinology 1999;140(5):2398-404.
1999: Serino R; Ueta Y; Hara Y; Nomura M; Yamamoto Y; Shibuya I; Hattori Y; Kitamura K; Kangawa K; Russell J A; Yamashita H
Centrally administered adrenomedullin increases plasma oxytocin level with induction of c-fos messenger ribonucleic acid in the paraventricular and supraoptic nuclei of the rat.
Endocrinology 1999;140(5):2334-42.
1999: Nagaya N; Nishikimi T; Uematsu M; Yoshitomi Y; Miyao Y; Miyazaki S; Goto Y; Kojima S; Kuramochi M; Matsuo H; Kangawa K; Nonogi H
Plasma adrenomedullin as an indicator of prognosis after acute myocardial infarction.
Heart (British Cardiac Society) 1999;81(5):483-7.
1999: Makino I; Shibata K; Makino Y; Kangawa K; Kawarabayashi T
Adrenomedullin attenuates the hypertension in hypertensive pregnant rats induced by N(G)-nitro-L-arginine methyl ester.
European journal of pharmacology 1999;371(2-3):159-67.
1999: Nagata D; Hirata Y; Suzuki E; Kakoki M; Hayakawa H; Goto A; Ishimitsu T; Minamino N; Ono Y; Kangawa K; Matsuo H; Omata M
Hypoxia-induced adrenomedullin production in the kidney.
Kidney international 1999;55(4):1259-67.
1999: Nishitani Y; Kubo A; Kaneko Y; Ono Y; Kurioka H; Kurooka K; Minamino N; Kangawa K; Okada K; Nonaka H; Dohi K
Increased urinary levels of adrenomedullin in patients with cystitis.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1999;33(4):772-7.
1999: Fujimoto K; Ohta K; Kangawa K; Kikkawa U; Ogino S; Fukui H
Identification of protein kinase C phosphorylation sites involved in phorbol ester-induced desensitization of the histamine H1 receptor.
Molecular pharmacology 1999;55(4):735-42.
1999: Hayashi Y; Minamino N; Isumi Y; Kangawa K; Kuro M; Matsuo H
Effects of thiopental, ketamine, etomidate, propofol and midazolam on the production of adrenomedullin and endothelin-1 in vascular smooth muscle cells.
Research communications in molecular pathology and pharmacology 1999;103(3):325-31.
1999: Kato J; Kitamura K; Matsui E; Tanaka M; Ishizaka Y; Kita T; Kangawa K; Eto T
Plasma adrenomedullin and natriuretic peptides in patients with essential or malignant hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 1999;22(1):61-5.
1999: Hino J; Matsuo H; Kangawa K
Bone morphogenetic protein-3b (BMP-3b) gene expression is correlated with differentiation in rat calvarial osteoblasts.
Biochemical and biophysical research communications 1999;256(2):419-24.
1999: Hirayama N; Kitamura K; Imamura T; Kato J; Koiwaya Y; Tsuji T; Kangawa K; Eto T
Molecular forms of circulating adrenomedullin in patients with congestive heart failure.
The Journal of endocrinology 1999;160(2):297-303.
1999: Nagaya N; Goto Y; Nishikimi T; Uematsu M; Miyao Y; Kobayashi Y; Miyazaki S; Hamada S; Kuribayashi S; Takamiya M; Matsuo H; Kangawa K; Nonogi H
Sustained elevation of plasma brain natriuretic peptide levels associated with progressive ventricular remodelling after acute myocardial infarction.
Clinical science (London, England : 1979) 1999;96(2):129-36.
1999: Michishita M; Minegishi T; Abe K; Kangawa K; Kojima M; Ibuki Y
Expression of adrenomedullin in the endometrium of the human uterus.
Obstetrics and gynecology 1999;93(1):66-70.
1999: Date Y; Ueta Y; Yamashita H; Yamaguchi H; Matsukura S; Kangawa K; Sakurai T; Yanagisawa M; Nakazato M
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):748-53.
1999: Nagaya N; Nishikimi T; Horio T; Yoshihara F; Kanazawa A; Matsuo H; Kangawa K
Cardiovascular and renal effects of adrenomedullin in rats with heart failure.
The American journal of physiology 1999;276(1 Pt 2):R213-8.
1999: Kakishita M; Nishikimi T; Okano Y; Satoh T; Kyotani S; Nagaya N; Fukushima K; Nakanishi N; Takishita S; Miyata A; Kangawa K; Matsuo H; Kunieda T
Increased plasma levels of adrenomedullin in patients with pulmonary hypertension.
Clinical science (London, England : 1979) 1999;96(1):33-9.
1999: Ueta Y; Hara Y; Setiadji V S; Isse T; Shibuya I; Kitamura K; Kangawa K; Matsuo H; Eto T; Hattori Y; Yamashita H
Adrenomedullin-like immunoreactivity in the rat hypothalamo-neurohypophysial tract.
Peptides 1999;20(2):199-204.
1998: Miyata A; Sato K; Hino J; Tamakawa H; Matsuo H; Kangawa K
Rat aortic smooth-muscle cell proliferation is bidirectionally regulated in a cell cycle-dependent manner via PACAP/VIP type 2 receptor.
Annals of the New York Academy of Sciences 1998;865():73-81.
1998: Sakata J; Asada Y; Shimokubo T; Kitani M; Inatsu H; Kitamura K; Kangawa K; Matsuo H; Sumiyoshi A; Eto T
Adrenomedullin in the gastrointestinal tract. Distribution and gene expression in rat and augmented gastric adrenomedullin after fasting.
Journal of gastroenterology 1998;33(6):828-34.
1998: Abe K; Minegishi T; Tano M; Hirakawa T; Tsuchiya M; Kangawa K; Kojima M; Ibuki Y
Expression and effect of adrenomedullin on rat granulosa cell.
Endocrinology 1998;139(12):5263-6.
1998: Nakazato M; Yamaguchi H; Date Y; Miyazato M; Kangawa K; Goy M F; Chino N; Matsukura S
Tissue distribution, cellular source, and structural analysis of rat immunoreactive uroguanylin.
Endocrinology 1998;139(12):5247-54.
1998: Horio T; Nishikimi T; Yoshihara F; Nagaya N; Matsuo H; Takishita S; Kangawa K
Production and secretion of adrenomedullin in cultured rat cardiac myocytes and nonmyocytes: stimulation by interleukin-1beta and tumor necrosis factor-alpha.
Endocrinology 1998;139(11):4576-80.
1998: Fujimoto K; Ohta K; Kangawa K; Kikkawa U; Ogino S; Fukui H
[Identification of protein kinase C phosphorylation sites involved in desensitization of the histamine H1 receptor]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1998;112 Suppl 1():143P-147P.
1998: Ono Y; Kojima M; Okada K; Kangawa K
cDNA cloning of canine adrenomedullin and its gene expression in the heart and blood vessels in endotoxin shock.
Shock (Augusta, Ga.) 1998;10(4):243-7.
1998: Kikumoto K; Kubo A; Hayashi Y; Minamino N; Inoue S; Dohi K; Kitamura K; Kangawa K; Matsuo H; Furuya H
Increased plasma concentration of adrenomedullin in patients with subarachnoid hemorrhage.
Anesthesia and analgesia 1998;87(4):859-63.
1998: Kubo A; Kurioka H; Minamino N; Nishitani Y; Sato H; Nishino T; Iwano M; Shiiki H; Kangawa K; Matsuo H; Dohi K
Plasma and urinary levels of adrenomedullin in chronic glomerulonephritis patients with proteinuria.
Nephron 1998;80(2):227-30.
1998: Shinoki N; Kawasaki T; Minamino N; Okahara K; Ogawa A; Ariyoshi H; Sakon M; Kambayashi J; Kangawa K; Monden M
Shear stress down-regulates gene transcription and production of adrenomedullin in human aortic endothelial cells.
Journal of cellular biochemistry 1998;71(1):109-15.
1998: Yoshihara F; Nishikimi T; Horio T; Yutani C; Takishita S; Matsuo H; Ohe T; Kangawa K
Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline.
European journal of pharmacology 1998;355(1):33-9.
1998: Nishi M; Komazaki S; Iino M; Kangawa K; Takeshima H
Mitsugumin23, a novel transmembrane protein on endoplasmic reticulum and nuclear membranes.
FEBS letters 1998;432(3):191-6.
1998: Nishikimi T; Horio T; Yoshihara F; Nagaya N; Matsuo H; Kangawa K
Effect of adrenomedullin on cAMP and cGMP levels in rat cardiac myocytes and nonmyocytes.
European journal of pharmacology 1998;353(2-3):337-44.
1998: Kubo A; Minamino N; Isumi Y; Katafuchi T; Kangawa K; Dohi K; Matsuo H
Production of adrenomedullin in macrophage cell line and peritoneal macrophage.
The Journal of biological chemistry 1998;273(27):16730-8.
1998: Yamaguchi H; Nakazato M; Miyazato M; Toshimori H; Oki S; Shimizu K; Suiko M; Kangawa K; Matsukura S
Identification of a novel splicing mutation and 1-bp deletion in the 17alpha-hydroxylase gene of Japanese patients with 17alpha-hydroxylase deficiency.
Human genetics 1998;102(6):635-9.
1998: Yang N; Higuchi O; Ohashi K; Nagata K; Wada A; Kangawa K; Nishida E; Mizuno K
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization.
Nature 1998;393(6687):809-12.
1998: Isumi Y; Minamino N; Katafuchi T; Yoshioka M; Tsuji T; Kangawa K; Matsuo H
Adrenomedullin production in fibroblasts: its possible function as a growth regulator of Swiss 3T3 cells.
Endocrinology 1998;139(5):2552-63.
1998: Kubo A; Minamino N; Isumi Y; Kangawa K; Dohi K; Matsuo H
Adrenomedullin production is correlated with differentiation in human leukemia cell lines and peripheral blood monocytes.
FEBS letters 1998;426(2):233-7.
1998: Kitamura K; Kato J; Kawamoto M; Tanaka M; Chino N; Kangawa K; Eto T
The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma.
Biochemical and biophysical research communications 1998;244(2):551-5.
1998: Isumi Y; Minamino N; Kubo A; Nishimoto N; Yoshizaki K; Yoshioka M; Kangawa K; Matsuo H
Adrenomedullin stimulates interleukin-6 production in Swiss 3T3 cells.
Biochemical and biophysical research communications 1998;244(2):325-31.
1998: Isumi Y; Shoji H; Sugo S; Tochimoto T; Yoshioka M; Kangawa K; Matsuo H; Minamino N
Regulation of adrenomedullin production in rat endothelial cells.
Endocrinology 1998;139(3):838-46.
1998: Miyao Y; Nishikimi T; Goto Y; Miyazaki S; Daikoku S; Morii I; Matsumoto T; Takishita S; Miyata A; Matsuo H; Kangawa K; Nonogi H
Increased plasma adrenomedullin levels in patients with acute myocardial infarction in proportion to the clinical severity.
Heart (British Cardiac Society) 1998;79(1):39-44.
1998: Nagaya N; Nishikimi T; Goto Y; Miyao Y; Kobayashi Y; Morii I; Daikoku S; Matsumoto T; Miyazaki S; Matsuoka H; Takishita S; Kangawa K; Matsuo H; Nonogi H
Plasma brain natriuretic peptide is a biochemical marker for the prediction of progressive ventricular remodeling after acute myocardial infarction.
American heart journal 1998;135(1):21-8.
1998: Tsuruda T; Kato J; Kitamura K; Kuwasako K; Imamura T; Koiwaya Y; Tsuji T; Kangawa K; Eto T
Adrenomedullin: a possible autocrine or paracrine inhibitor of hypertrophy of cardiomyocytes.
Hypertension 1998;31(1 Pt 2):505-10.
1998: Nagaya N; Nishikimi T; Okano Y; Uematsu M; Satoh T; Kyotani S; Kuribayashi S; Hamada S; Kakishita M; Nakanishi N; Takamiya M; Kunieda T; Matsuo H; Kangawa K
Plasma brain natriuretic peptide levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension.
Journal of the American College of Cardiology 1998;31(1):202-8.
1998: Tamakawa H; Miyata A; Satoh K; Miyake Y; Matsuo H; Arimura A; Kangawa K
The augmentation of pituitary adenylate cyclase-activating polypeptide (PACAP) in streptozotocin-induced diabetic rats.
Peptides 1998;19(9):1497-502.
1998: Kubo A; Iwano M; Minamino N; Sato H; Nishino T; Hirata E; Akai Y; Shiiki H; Kitamura K; Kangawa K; Matsuo H; Dohi K
Measurement of plasma and urinary adrenomedullin in patients with IgA nephropathy.
Nephron 1998;78(4):389-94.
1997: Nishikimi T; Horio T; Sasaki T; Yoshihara F; Takishita S; Miyata A; Matsuo H; Kangawa K
Cardiac production and secretion of adrenomedullin are increased in heart failure.
Hypertension 1997;30(6):1369-75.
1997: Nishikimi T; Nagata S; Sasaki T; Tomimoto S; Matsuoka H; Takishita S; Kitamura K; Miyata A; Matsuo H; Kangawa K
Plasma concentrations of adrenomedullin correlate with the extent of pulmonary hypertension in patients with mitral stenosis.
Heart (British Cardiac Society) 1997;78(4):390-5.
1997: Ueno H; Haruno A; Morisaki N; Furuya M; Kangawa K; Takeshita A; Saito Y
Local expression of C-type natriuretic peptide markedly suppresses neointimal formation in rat injured arteries through an autocrine/paracrine loop.
Circulation 1997;96(7):2272-9.
1997: Kuwasako K; Kitamura K; Ishiyama Y; Washimine H; Kato J; Kangawa K; Eto T
Purification and characterization of PAMP-12 (PAMP[9-20]) in porcine adrenal medulla as a major endogenous biologically active peptide.
FEBS letters 1997;414(1):105-10.
1997: Date Y; Nakazato M; Kangawa K; Shirieda K; Fujimoto T; Matsukura S
Detection of three transthyretin gene mutations in familial amyloidotic polyneuropathy by analysis of DNA extracted from formalin-fixed and paraffin-embedded tissues.
Journal of the neurological sciences 1997;150(2):143-8.
1997: Khan A I; Kato J; Ishiyama Y; Kitamura K; Kangawa K; Eto T
Effect of chronically infused adrenomedullin in two-kidney, one-clip hypertensive rats.
European journal of pharmacology 1997;333(2-3):187-90.
1997: Miyazato M; Nakazato M; Matsukura S; Kangawa K; Matsuo H
Genomic structure and chromosomal localization of human uroguanylin.
Genomics 1997;43(3):359-65.
1997: Yamamoto S; Morimoto I; Yanagihara N; Kangawa K; Inenaga K; Eto S; Yamashita H
C-type natriuretic peptide suppresses arginine-vasopressin secretion from dissociated magnocellular neurons in newborn rat supraoptic nucleus.
Neuroscience letters 1997;229(2):97-100.
1997: Ishiyama Y; Kitamura K; Kato J; Sakata J; Kangawa K; Eto T
Changes in cardiac adrenomedullin concentration in renovascular hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 1997;20(2):113-7.
1997: Shirai M; Shimouchi A; Ikeda S; Ninomiya I; Sunagawa K; Kangawa K; Matsuo H
Vasodilator effects of adrenomedullin on small pulmonary arteries and veins in anaesthetized cats.
British journal of pharmacology 1997;121(4):679-86.
1997: Yoshibayashi M; Kamiya T; Kitamura K; Saito Y; Kangawa K; Nishikimi T; Matsuoka H; Eto T; Matsuo H
Plasma levels of adrenomedullin in primary and secondary pulmonary hypertension in patients <20 years of age.
The American journal of cardiology 1997;79(11):1556-8.
1997: Yamaguchi H; Nakazato M; Miyazato M; Kangawa K; Matsukura S
A 5'-splice site mutation in the cytochrome P450 steroid 17alpha-hydroxylase gene in 17alpha-hydroxylase deficiency.
The Journal of clinical endocrinology and metabolism 1997;82(6):1934-8.
1997: Ikenouchi H; Kangawa K; Matsuo H; Hirata Y
Negative inotropic effect of adrenomedullin in isolated adult rabbit cardiac ventricular myocytes.
Circulation 1997;95(9):2318-24.
1997: Khan A I; Kato J; Kitamura K; Kangawa K; Eto T
Hypotensive effect of chronically infused adrenomedullin in conscious Wistar-Kyoto and spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology 1997;24(2):139-42.
1997: Etoh T; Kato J; Washimine H; Imamura T; Kitamura K; Koiwaya Y; Kangawa K; Eto T
Plasma proadrenomedullin N-terminal 20 peptide (PAMP) in patients with congestive heart failure.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1997;29(1):46-7.
1997: Ishihara T; Kato J; Kitamura K; Katoh F; Fujimoto S; Kangawa K; Eto T
Production of adrenomedullin in human vascular endothelial cells.
Life sciences 1997;60(20):1763-9.
1996: Kangawa K; Kitamura K; Minamino N; Eto T; Matsuo H
Adrenomedullin: a new hypotensive peptide.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1996;14(5):S105-10.
1996: Tanaka M; Ishizaka Y; Ishiyama Y; Kato J; Kida O; Kitamura K; Kangawa K; Eto T
Chronic effect of beta-adrenoceptor blockade on plasma levels of brain natriuretic peptide during exercise in essential hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 1996;19(4):239-45.
1996: Miyazato M; Nakazato M; Matsukura S; Kangawa K; Matsuo H
Uroguanylin gene expression in the alimentary tract and extra-gastrointestinal tissues.
FEBS letters 1996;398(2-3):170-4.
1996: Kangawa K; Kitamura K; Minamino N; Matsuo H
Adrenomedullin: a new modulator of vascular tone.
Journal of cardiac failure 1996;2(4 Suppl):S135-40.
1996: Osajima A; Uezono Y; Tamura M; Kitamura K; Mutoh Y; Ueta Y; Kangawa K; Kawamura M; Eto T; Yamashita H; Izumi F; Takasugi M; Kuroiwa A
Adrenomedullin-sensitive receptors are preferentially expressed in cultured rat mesangial cells.
European journal of pharmacology 1996;315(3):319-25.
1996: Shimokubo T; Sakata J; Kitamura K; Kangawa K; Matsuo H; Eto T
Adrenomedullin: changes in circulating and cardiac tissue concentration in Dahl salt-sensitive rats on a high-salt diet.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1996;18(7):949-61.
1996: Ishimitsu T; Nishikimi T; Matsuoka H; Kangawa K; Kitamura K; Minami J; Matsuo H; Eto T
Behaviour of adrenomedullin during acute and chronic salt loading in normotensive and hypertensive subjects.
Clinical science (London, England : 1979) 1996;91(3):293-8.
1996: Nishikimi T; Yoshihara F; Morimoto A; Ishikawa K; Ishimitsu T; Saito Y; Kangawa K; Matsuo H; Omae T; Matsuoka H
Relationship between left ventricular geometry and natriuretic peptide levels in essential hypertension.
Hypertension 1996;28(1):22-30.
1996: Nishikimi T; Matsuoka H; Ishikawa K; Yoshihara F; Kawano Y; Kitamura K; Saito Y; Kangawa K; Matsuo H; Omae T
Antihypertensive therapy reduces increased plasma levels of adrenomedullin and brain natriuretic peptide concomitant with regression of left ventricular hypertrophy in a patient with malignant hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 1996;19(2):97-101.
1996: Nagatomo Y; Kitamura K; Kangawa K; Fujimoto Y; Eto T
Proadrenomedullin N-terminal 20 peptide is rapidly cleaved by neutral endopeptidase.
Biochemical and biophysical research communications 1996;223(3):539-43.
1996: Hino J; Takao M; Takeshita N; Konno Y; Nishizawa T; Matsuo H; Kangawa K
cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b).
Biochemical and biophysical research communications 1996;223(2):304-10.
1996: Nakazato M; Yamaguchi H; Kinoshita H; Kangawa K; Matsuo H; Chino N; Matsukura S
Identification of biologically active and inactive human uroguanylins in plasma and urine and their increases in renal insufficiency.
Biochemical and biophysical research communications 1996;220(3):586-93.
1996: Inatsu H; Sakata J; Shimokubo T; Kitani M; Nishizono M; Washimine H; Kitamura K; Kangawa K; Matsuo H; Eto T
Distribution and characterization of rat immunoreactive proadrenomedullin N-terminal 20 peptide (PAMP) and the augmented cardiac PAMP in spontaneously hypertensive rat.
Biochemistry and molecular biology international 1996;38(2):365-72.
1996: Takao M; Hino J; Takeshita N; Konno Y; Nishizawa T; Matsuo H; Kangawa K
Identification of rat bone morphogenetic protein-3b (BMP-3b), a new member of BMP-3.
Biochemical and biophysical research communications 1996;219(2):656-62.
1996: Miyazato M; Nakazato M; Yamaguchi H; Date Y; Kojima M; Kangawa K; Matsuo H; Matsukura S
Cloning and characterization of a cDNA encoding a precursor for human uroguanylin.
Biochemical and biophysical research communications 1996;219(2):644-8.
1996: Kato J; Kobayashi K; Etoh T; Tanaka M; Kitamura K; Imamura T; Koiwaya Y; Kangawa K; Eto T
Plasma adrenomedullin concentration in patients with heart failure.
The Journal of clinical endocrinology and metabolism 1996;81(1):180-3.
1996: Makino Y; Minamino N; Kakishita E; Kangawa K; Matsuo H
Natriuretic peptides in water-deprived and in salt-loaded rats.
Peptides 1996;17(6):1031-9.
1995: Ueta Y; Kitamura K; Isse T; Shibuya I; Kabashima N; Yamamoto S; Kangawa K; Matsuo H; Eto T; Yamashita H
Adrenomedullin-immunoreactive neurons in the paraventricular and supraoptic nuclei of the rat.
Neuroscience letters 1995;202(1-2):37-40.
1995: Washimine H; Yamamoto Y; Kitamura K; Tanaka M; Ichiki Y; Kangawa K; Matsuo H; Eto T
Plasma concentration of human adrenomedullin in patients on hemodialysis.
Clinical nephrology 1995;44(6):389-93.
1995: Nishikimi T; Saito Y; Kitamura K; Ishimitsu T; Eto T; Kangawa K; Matsuo H; Omae T; Matsuoka H
Increased plasma levels of adrenomedullin in patients with heart failure.
Journal of the American College of Cardiology 1995;26(6):1424-31.
1995: Kato K; Kitamura K; Kuwasako K; Tanaka M; Ishiyama Y; Shimokubo T; Ichiki Y; Nakamura S; Kangawa K; Eto T
Plasma adrenomedullin in patients with primary aldosteronism.
American journal of hypertension 1995;8(10 Pt 1):997-1000.
1995: Ichiki Y; Kitamura K; Kangawa K; Kawamoto M; Matsuo H; Eto T
Distribution and characterization of immunoreactive adrenomedullin in porcine tissue, and isolation of adrenomedullin [26-52] and adrenomedullin [34-52] from porcine duodenum.
Journal of biochemistry 1995;118(4):765-70.
1995: Shoji H; Minamino N; Kangawa K; Matsuo H
Endotoxin markedly elevates plasma concentration and gene transcription of adrenomedullin in rat.
Biochemical and biophysical research communications 1995;215(2):531-7.
1995: Ishiyama Y; Kitamura K; Ichiki Y; Sakata J; Kida O; Kangawa K; Eto T
Haemodynamic responses to rat adrenomedullin in anaesthetized spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology 1995;22(9):614-8.
1995: Shimosawa T; Ito Y; Ando K; Kitamura K; Kangawa K; Fujita T
Proadrenomedullin NH(2)-terminal 20 peptide, a new product of the adrenomedullin gene, inhibits norepinephrine overflow from nerve endings.
The Journal of clinical investigation 1995;96(3):1672-6.
1995: Yamaguchi H; Nakazato M; Miyazato M; Kangawa K; Matsuo H; Matsukura S
Two novel rat guanylin molecules, guanylin-94 and guanylin-16, do not increase cyclic GMP production in T84 cells.
Biochemical and biophysical research communications 1995;214(3):1204-10.
1995: Tanaka M; Kitamura K; Ishizaka Y; Ishiyama Y; Kato J; Kangawa K; Eto T
Plasma adrenomedullin in various diseases and exercise-induced change in adrenomedullin in healthy subjects.
Internal medicine (Tokyo, Japan) 1995;34(8):728-33.
1995: Sugo S; Minamino N; Shoji H; Kangawa K; Matsuo H
Effects of vasoactive substances and cAMP related compounds on adrenomedullin production in cultured vascular smooth muscle cells.
FEBS letters 1995;369(2-3):311-4.
1995: Kuwasako K; Kitamura K; Ichiki Y; Kato J; Kangawa K; Matsuo H; Eto T
Human proadrenomedullin N-terminal 20 peptide in pheochromocytoma and normal adrenal medulla.
Biochemical and biophysical research communications 1995;211(2):694-9.
1995: Minamino N; Shoji H; Sugo S; Kangawa K; Matsuo H
Adrenocortical steroids, thyroid hormones and retinoic acid augment the production of adrenomedullin in vascular smooth muscle cells.
Biochemical and biophysical research communications 1995;211(2):686-93.
1995: Nakazato M; Shiomi K; Date Y; Matsukura S; Kangawa K; Minamino N; Matsuo H
Isolation and sequence determination of 6- and 8-kDa precursors of human neutrophil peptides from bone marrow, plasma and peripheral blood neutrophils.
Biochemical and biophysical research communications 1995;211(3):1053-62.
1995: Tanaka M; Ishizaka Y; Ishiyama Y; Kato J; Kida O; Kitamura K; Kangawa K; Matsuo H; Eto T
Exercise-induced secretion of brain natriuretic peptide in essential hypertension and normal subjects.
Hypertension research : official journal of the Japanese Society of Hypertension 1995;18(2):159-66.
1995: Kitamura K; Kangawa K; Matsuo H; Eto T
Adrenomedullin. Implications for hypertension research.
Drugs 1995;49(4):485-95.
1995: Hirata Y; Hayakawa H; Suzuki Y; Suzuki E; Ikenouchi H; Kohmoto O; Kimura K; Kitamura K; Eto T; Kangawa K
Mechanisms of adrenomedullin-induced vasodilation in the rat kidney.
Hypertension 1995;25(4 Pt 2):790-5.
1995: Washimine H; Asada Y; Kitamura K; Ichiki Y; Hara S; Yamamoto Y; Kangawa K; Sumiyoshi A; Eto T
Immunohistochemical identification of adrenomedullin in human, rat, and porcine tissue.
Histochemistry and cell biology 1995;103(4):251-4.
1995: Kato J; Kitamura K; Kangawa K; Eto T
Receptors for adrenomedullin in human vascular endothelial cells.
European journal of pharmacology 1995;289(2):383-5.
1995: Ishizaka Y; Yamamoto Y; Tanaka M; Kato F; Ishizaka Y; Yokota N; Kato J; Kitamura K; Eto T; Kangawa K
Molecular forms of human brain natriuretic peptide (BNP) in plasma of patients on hemodialysis (HD).
Clinical nephrology 1995;43(4):237-42.
1995: Sugo S; Minamino N; Shoji H; Kangawa K; Kitamura K; Eto T; Matsuo H
Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells.
Biochemical and biophysical research communications 1995;207(1):25-32.
1995: Katoh F; Kitamura K; Niina H; Yamamoto R; Washimine H; Kangawa K; Yamamoto Y; Kobayashi H; Eto T; Wada A
Proadrenomedullin N-terminal 20 peptide (PAMP), an endogenous anticholinergic peptide: its exocytotic secretion and inhibition of catecholamine secretion in adrenal medulla.
Journal of neurochemistry 1995;64(1):459-61.
1995: Shimokubo T; Sakata J; Kitamura K; Kangawa K; Matsuo H; Eto T
Augmented adrenomedullin concentrations in right ventricle and plasma of experimental pulmonary hypertension.
Life sciences 1995;57(19):1771-9.
1994: Nakazato M; Yamaguchi H; Shiomi K; Date Y; Fujimoto S; Kangawa K; Matsuo H; Matsukura S
Identification of 10-kDa proguanylin as a major guanylin molecule in human intestine and plasma and its increase in renal insufficiency.
Biochemical and biophysical research communications 1994;205(3):1966-75.
1994: Ishimitsu T; Nishikimi T; Saito Y; Kitamura K; Eto T; Kangawa K; Matsuo H; Omae T; Matsuoka H
Plasma levels of adrenomedullin, a newly identified hypotensive peptide, in patients with hypertension and renal failure.
The Journal of clinical investigation 1994;94(5):2158-61.
1994: Nishikimi T; Kitamura K; Saito Y; Shimada K; Ishimitsu T; Takamiya M; Kangawa K; Matsuo H; Eto T; Omae T
Clinical studies on the sites of production and clearance of circulating adrenomedullin in human subjects.
Hypertension 1994;24(5):600-4.
1994: Sakata J; Shimokubo T; Kitamura K; Nishizono M; Iehiki Y; Kangawa K; Matsuo H; Eto T
Distribution and characterization of immunoreactive rat adrenomedullin in tissue and plasma.
FEBS letters 1994;352(2):105-8.
1994: Date Y; Nakazato M; Shiomi K; Toshimori H; Kangawa K; Matsuo H; Matsukura S
Localization of human neutrophil peptide (HNP) and its messenger RNA in neutrophil series.
Annals of hematology 1994;69(2):73-7.
1994: Kitamura K; Kangawa K; Ishiyama Y; Washimine H; Ichiki Y; Kawamoto M; Minamino N; Matsuo H; Eto T
Identification and hypotensive activity of proadrenomedullin N-terminal 20 peptide (PAMP).
FEBS letters 1994;351(1):35-7.
1994: Sugo S; Minamino N; Shoji H; Kangawa K; Kitamura K; Eto T; Matsuo H
Production and secretion of adrenomedullin from vascular smooth muscle cells: augmented production by tumor necrosis factor-alpha.
Biochemical and biophysical research communications 1994;203(1):719-26.
1994: Washimine H; Kitamura K; Ichiki Y; Yamamoto Y; Kangawa K; Matsuo H; Eto T
Immunoreactive proadrenomedullin N-terminal 20 peptide in human tissue, plasma and urine.
Biochemical and biophysical research communications 1994;202(2):1081-7.
1994: Katoh F; Niina H; Kitamura K; Ichiki Y; Yamamoto Y; Kangawa K; Eto T; Wada A
Ca(2+)-dependent cosecretion of adrenomedullin and catecholamines mediated by nicotinic receptors in bovine cultured adrenal medullary cells.
FEBS letters 1994;348(1):61-4.
1994: Sugo S; Minamino N; Kangawa K; Miyamoto K; Kitamura K; Sakata J; Eto T; Matsuo H
Endothelial cells actively synthesize and secrete adrenomedullin.
Biochemical and biophysical research communications 1994;201(3):1160-6.
1994: Ishizaka Y; Ishizaka Y; Tanaka M; Kitamura K; Kangawa K; Minamino N; Matsuo H; Eto T
Adrenomedullin stimulates cyclic AMP formation in rat vascular smooth muscle cells.
Biochemical and biophysical research communications 1994;200(1):642-6.
1994: Hirata Y; Suzuki Y; Suzuki E; Hayakawa H; Kimura K; Goto A; Omata M; Minamino N; Kangawa K; Matsuo H
Mechanisms underlying the augmented responses of deoxycorticosterone acetate-salt hypertensive rats to neutral endopeptidase inhibitors.
Journal of hypertension 1994;12(4):367-74.
1994: Kitamura K; Ichiki Y; Tanaka M; Kawamoto M; Emura J; Sakakibara S; Kangawa K; Matsuo H; Eto T
Immunoreactive adrenomedullin in human plasma.
FEBS letters 1994;341(2-3):288-90.
1994: Kitamura K; Kangawa K; Kojima M; Ichiki Y; Matsuo H; Eto T
Complete amino acid sequence of porcine adrenomedullin and cloning of cDNA encoding its precursor.
FEBS letters 1994;338(3):306-10.
1994: Hirata Y; Suzuki E; Hayakawa H; Matsuoka H; Sugimoto T; Kangawa K; Matsuo H
Mechanisms of the natriuretic effects of neutral endopeptidase inhibition in Dahl salt-sensitive and salt-resistant rats.
Journal of cardiovascular pharmacology 1994;23(2):283-90.
1994: Ichiki Y; Kitamura K; Kangawa K; Kawamoto M; Matsuo H; Eto T
Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma.
FEBS letters 1994;338(1):6-10.
1993: Minamino N; Aburaya M; Kojima M; Miyamoto K; Kangawa K; Matsuo H
Distribution of C-type natriuretic peptide and its messenger RNA in rat central nervous system and peripheral tissue.
Biochemical and biophysical research communications 1993;197(1):326-35.
1993: Ishiyama Y; Kitamura K; Ichiki Y; Nakamura S; Kida O; Kangawa K; Eto T
Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats.
European journal of pharmacology 1993;241(2-3):271-3.
1993: Shiomi K; Nakazato M; Ihi T; Kangawa K; Matsuo H; Matsukura S
Establishment of radioimmunoassay for human neutrophil peptides and their increases in plasma and neutrophil in infection.
Biochemical and biophysical research communications 1993;195(3):1336-44.
1993: Sakata J; Shimokubo T; Kitamura K; Nakamura S; Kangawa K; Matsuo H; Eto T
Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide.
Biochemical and biophysical research communications 1993;195(2):921-7.
1993: Shiomi K; Nakazato M; Matsukura S; Ohnishi A; Hatanaka H; Tsuji S; Murai Y; Kojima M; Kangawa K; Matsuo H
A basic transthyretin variant (Glu61-->Lys) causes familial amyloidotic polyneuropathy: protein and DNA sequencing and PCR-induced mutation restriction analysis.
Biochemical and biophysical research communications 1993;194(3):1090-6.
1993: Yokota N; Yamamoto Y; Kitamura K; Kangawa K; Minamino N; Matsuo H; Eto T
Alterations in circulating and cardiac tissue concentrations of brain natriuretic peptide in spontaneously hypertensive rats.
Cardiovascular research 1993;27(7):1312-5.
1993: Kitamura K; Sakata J; Kangawa K; Kojima M; Matsuo H; Eto T
Cloning and characterization of cDNA encoding a precursor for human adrenomedullin.
Biochemical and biophysical research communications 1993;194(2):720-5.
1993: Suzuki E; Hirata Y; Hayakawa H; Omata M; Kojima M; Kangawa K; Minamino N; Matsuo H
Evidence for C-type natriuretic peptide production in the rat kidney.
Biochemical and biophysical research communications 1993;192(2):532-8.
1993: Ichiki Y; Kitamura K; Kangawa K; Eto T
Dimeric form of calcitonin gene-related peptide in the porcine thyroid gland.
Biochemical and biophysical research communications 1993;191(3):961-7.
1993: Hirata Y; Matsuoka H; Suzuki E; Hayakawa H; Sugimoto T; Matsuda Y; Morishita Y; Kangawa K; Minamino N; Matsuo H
Role of endogenous atrial natriuretic peptide in DOCA-salt hypertensive rats. Effects of a novel nonpeptide antagonist for atrial natriuretic peptide receptor.
Circulation 1993;87(2):554-61.
1993: Yokota N; Yamamoto Y; Iemura F; Kita T; Kangawa K; Minamino N; Matsuo H; Eto T
Increased plasma levels and effects of brain natriuretic peptide in experimental nephrosis.
Nephron 1993;65(3):454-9.
1993: Ohyama Y; Miyamoto K; Morishita Y; Matsuda Y; Kojima M; Minamino N; Kangawa K; Matsuo H
HS-142-1, a novel antagonist for natriuretic peptides, has no effect on the third member of membrane bound guanylate cyclases (GC-C) in T84 cells.
Life sciences 1993;52(17):PL153-7.
1992: Ohyama Y; Miyamoto K; Morishita Y; Matsuda Y; Saito Y; Minamino N; Kangawa K; Matsuo H
Stable expression of natriuretic peptide receptors: effects of HS-142-1, a non-peptide ANP antagonist.
Biochemical and biophysical research communications 1992;189(1):336-42.
1992: Ishimitsu T; Hirata Y; Matsuoka H; Ishii M; Sugimoto T; Kangawa K; Matsuo H
In vivo and in vitro effects of atrial natriuretic peptide on renin release.
Clinical and experimental pharmacology & physiology 1992;19(10):711-6.
1992: Ichiki Y; Kitamura K; Kangawa K; Kawamoto M; Matsuo H; Eto T
Organ distribution and characterization of porcine peptides (VIP, CGRP and PHI) that increase cAMP in rat platelets.
Biochemical and biophysical research communications 1992;187(3):1587-93.
1992: Shiomi K; Nakazato M; Miyazato M; Kangawa K; Matsuo H; Matsukura S
Establishment of hypersensitive radioimmunoassay for islet amyloid polypeptide using antiserum specific for its N-terminal region.
Biochemical and biophysical research communications 1992;186(2):1065-73.
1992: Hirata Y; Suzuki E; Hayakawa H; Matsuoka H; Sugimoto T; Kojima M; Kangawa K; Matsuo H
Role of endogenous ANP in sodium excretion in rats with experimental pulmonary hypertension.
The American journal of physiology 1992;262(6 Pt 2):H1684-9.
1992: Kitamura K; Kangawa K; Kawamoto M; Ichiki Y; Matsuo H; Eto T
Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma.
Biochemical and biophysical research communications 1992;185(1):134-41.
1992: Ohyama Y; Miyamoto K; Saito Y; Minamino N; Kangawa K; Matsuo H
Cloning and characterization of two forms of C-type natriuretic peptide receptor in rat brain.
Biochemical and biophysical research communications 1992;183(2):743-9.
1992: Suzuki E; Hirata Y; Matsuoka H; Sugimoto T; Hayakawa H; Sugimoto T; Kangawa K; Minamino N; Matsuo H
Characterization of atrial natriuretic peptide in urine from rats treated with a neutral endopeptidase inhibitor.
Biochemical and biophysical research communications 1992;182(3):1270-6.
1992: Miyazato M; Nakazato M; Shiomi K; Aburaya J; Kangawa K; Matsuo H; Matsukura S
Molecular forms of islet amyloid polypeptide (IAPP/amylin) in four mammals.
Diabetes research and clinical practice 1992;15(1):31-6.
1991: Miyazato M; Nakazato M; Shiomi K; Aburaya J; Toshimori H; Kangawa K; Matsuo H; Matsukura S
Identification and characterization of islet amyloid polypeptide in mammalian gastrointestinal tract.
Biochemical and biophysical research communications 1991;181(1):293-300.
1991: Kita T; Kida O; Yokota N; Eto T; Minamino N; Kangawa K; Matsuo H; Tanaka K
Effects of brain natriuretic peptide-45, a circulating form of rat brain natriuretic peptide, in spontaneously hypertensive rats.
European journal of pharmacology 1991;202(1):73-9.
1991: Matsuoka H; Fukui K; Dan Y; Ishimitsu T; Hirata Y; Kimura K; Sugimoto T; Ishii M; Kangawa K; Matsuo H
Atrial natriuretic peptide inhibits the aldosterone response to metoclopramide in patients with glomerular disease and essential hypertension.
Clinical and experimental pharmacology & physiology 1991;18(8):557-62.
1991: Minamino N; Makino Y; Tateyama H; Kangawa K; Matsuo H
Characterization of immunoreactive human C-type natriuretic peptide in brain and heart.
Biochemical and biophysical research communications 1991;179(1):535-42.
1991: Hirata Y; Matsuoka H; Hayakawa H; Sugimoto T; Suzuki E; Sugimoto T; Kangawa K; Matsuo H
Role of endogenous atrial natriuretic peptide in regulating sodium excretion in spontaneously hypertensive rats. Effects of neutral endopeptidase inhibition.
Hypertension 1991;17(6 Pt 2):1025-32.
1991: Yokota N; Yamamoto Y; Aburaya M; Kitamura K; Eto T; Kangawa K; Minamino N; Matsuo H; Tanaka K
Increased secretion of brain natriuretic peptide and atrial natriuretic peptide, but not sufficient to induce natriuresis in rats with nephrotic syndrome.
Biochemical and biophysical research communications 1991;174(1):128-35.
1991: Yokota N; Aburaya M; Yamamoto Y; Kato J; Kitamura K; Kida O; Eto T; Minamino N; Kangawa K; Matsuo H
Cardiac content of brain natriuretic peptide in DOCA salt-hypertensive rats.
Life sciences 1991;48(5):397-402.
1990: Yokota N; Aburaya M; Yamamoto Y; Kato J; Kitamura K; Kida O; Eto T; Minamino N; Kangawa K; Matsuo H
Increased plasma brain natriuretic peptide levels in DOCA-salt hypertensive rats: relation to blood pressure and cardiac concentration.
Biochemical and biophysical research communications 1990;173(2):632-8.
1990: Nakazato M; Asai J; Miyazato M; Matsukura S; Kangawa K; Matsuo H
Isolation and identification of islet amyloid polypeptide in normal human pancreas.
Regulatory peptides 1990;31(3):179-86.
1990: Toshimori H; Narita R; Nakazato M; Asai J; Mitsukawa T; Kangawa K; Matsuo H; Matsukura S
Islet amyloid polypeptide (IAPP) in the gastrointestinal tract and pancreas of man and rat.
Cell and tissue research 1990;262(3):401-6.
1990: Minamino N; Kangawa K; Matsuo H
N-terminally extended form of C-type natriuretic peptide (CNP-53) identified in porcine brain.
Biochemical and biophysical research communications 1990;170(2):973-9.
1990: Asai J; Nakazato M; Miyazato M; Kangawa K; Matsuo H; Matsukura S
Regional distribution and molecular forms of rat islet amyloid polypeptide.
Biochemical and biophysical research communications 1990;169(2):788-95.
1990: Nakazato M; Miyazato M; Asai J; Mitsukawa T; Kangawa K; Matsuo H; Matsukura S
Islet amyloid polypeptide, a novel pancreatic peptide, is a circulating hormone secreted under glucose stimulation.
Biochemical and biophysical research communications 1990;169(2):713-8.
1990: Kitamura K; Kangawa K; Tanaka K; Matsuo H
Isolation of NPY-25 (neuropeptide Y[12-36]), a potent inhibitor of calmodulin, from porcine brain.
Biochemical and biophysical research communications 1990;169(3):1164-71.
1990: Mitsukawa T; Takemura J; Asai J; Nakazato M; Kangawa K; Matsuo H; Matsukura S
Islet amyloid polypeptide response to glucose, insulin, and somatostatin analogue administration.
Diabetes 1990;39(5):639-42.
1989: Asai J; Nakazato M; Kangawa K; Matsukura S; Matsuo H
Isolation and sequence determination of rat islet amyloid polypeptide.
Biochemical and biophysical research communications 1989;164(1):400-5.
1989: Nakazato M; Asai J; Kangawa K; Matsukura S; Matsuo H
Establishment of radioimmunoassay for human islet amyloid polypeptide and its tissue content and plasma concentration.
Biochemical and biophysical research communications 1989;164(1):394-9.
1989: Hirata Y; Ishii M; Fukui K; Hayakawa H; Sugimoto T; Matsuoka H; Sugimoto T; Kangawa K; Matsuo H
Interaction between sympathetic nerve activity and atrial natriuretic peptide with respect to the effects on renal hemodynamics in patients with cardiovascular diseases.
Japanese circulation journal 1989;53(5):446-52.
1989: Kita T; Kida O; Kato J; Nakamura S; Eto T; Minamino N; Kangawa K; Matsuo H; Tanaka K
Natriuretic and hypotensive effects of brain natriuretic peptide in anaesthetized DOCA-salt hypertensive rats.
Clinical and experimental pharmacology & physiology 1989;16(3):185-90.
1989: Nakazato M; Tanaka M; Matsukura S; Kangawa K; Matsuo H
Quantitative analysis of amyloid fibril protein in systemic organs of patients with familial amyloidotic polyneuropathy.
Journal of the neurological sciences 1989;89(2-3):235-42.
1989: Kita T; Kida O; Kato J; Nakamura S; Eto T; Minamino N; Kangawa K; Matsuo H; Tanaka K
Natriuretic and hypotensive effects of brain natriuretic peptide (BNP) in spontaneously hypertensive rats.
Life sciences 1989;44(21):1541-5.
1988: Hirata Y; Ishii M; Matsuoka H; Sugimoto T; Iizuka M; Serizawa T; Kohmoto O; Sugimoto T; Miyata A; Kangawa K
Plasma concentration of alpha-hANP and renal responses to alpha-hANP infusion in patients with congestive heart failure and those with chronic renal failure.
Japanese circulation journal 1988;52(12):1459-64.
1988: Hirata Y; Ishii M; Sugimoto T; Matsuoka H; Fukui K; Sugimoto T; Yamakado M; Tagawa H; Miyata A; Kangawa K
Hormonal and renal effects of atrial natriuretic peptide in patients with secondary hypertension.
Circulation 1988;78(6):1401-10.
1987: Nakazato M; Tanaka M; Yamamura Y; Kurihara T; Matsukura S; Kangawa K; Matsuo H
Abnormal transthyretin in asymptomatic relatives in familial amyloidotic polyneuropathy.
Archives of neurology 1987;44(12):1275-8.

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