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Kenji Kangawa

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Yuanjie Mao; Mikiya Miyazato; Kentaro Otani; Takeshi Tokudome; Ichiro Kishimoto; Kenji Kangawa
Excessive sympathoactivation and deteriorated heart function after myocardial infarction in male ghrelin knockout mice.
Toshio Nishikimi; Kenji Kangawa; Koichiro Kuwahara; Naoto Minamino; Yasuaki Nakagawa; Kazuwa Nakao
Complexity of molecular forms of B-type natriuretic peptide in heart failure.
Rika Fukumori; Yoshihisa Hasegawa; Kenji Kangawa; Masayasu Kojima; Takako Mita; Taketo Obitsu; Toshihisa Sugino; Kohzo Taniguchi
Effects of intravenous ghrelin injection on plasma growth hormone, insulin and glucose concentrations in calves at weaning.

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2013: Yuanjie Mao; Mikiya Miyazato; Kentaro Otani; Takeshi Tokudome; Ichiro Kishimoto; Kenji Kangawa
Excessive sympathoactivation and deteriorated heart function after myocardial infarction in male ghrelin knockout mice.
Endocrinology 2013;154(5):1854-63.
2013: Toshio Nishikimi; Kenji Kangawa; Koichiro Kuwahara; Naoto Minamino; Yasuaki Nakagawa; Kazuwa Nakao
Complexity of molecular forms of B-type natriuretic peptide in heart failure.
Heart (British Cardiac Society) 2013;99(10):677-9.
2013: Rika Fukumori; Yoshihisa Hasegawa; Kenji Kangawa; Masayasu Kojima; Takako Mita; Taketo Obitsu; Toshihisa Sugino; Kohzo Taniguchi
Effects of intravenous ghrelin injection on plasma growth hormone, insulin and glucose concentrations in calves at weaning.
Animal science journal = Nihon chikusan Gakkaihō 2013;84(4):310-5.
2013: Shuji Takiguchi; Makoto Yamasaki; Yuichiro Hiura; Hiroshi Hosoda; Kenji Kangawa; Yukinori Kurokawa; Hiroshi Miyata; Masaki Mori; Kiyokazu Nakajima; Tsuyoshi Takahashi; Yuichiro Doki
Effect of rikkunshito, a Japanese herbal medicine, on gastrointestinal symptoms and ghrelin levels in gastric cancer patients after gastrectomy.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2013;16(2):167-74.
2013: Wakaba Tsuchimochi; Hideki Yamaguchi; Kenji Kangawa; Itaru Kyoraku; Kazutaka Shiomi; Koji Toshinai; Masamitsu Nakazato
Ghrelin prevents the development of experimental diabetic neuropathy in rodents.
European journal of pharmacology 2013;702(1-3):187-93.
2013: Hiroyuki Kaiya; Kenji Kangawa; Mikiya Miyazato
What is the general action of ghrelin for vertebrates? - comparisons of ghrelin's effects across vertebrates.
General and comparative endocrinology 2013;181():187-91.
2013: Yoshiyuki Inoue; Kenji Kangawa; Keisuke Maruyama; Keiko Nakahara; Yoshiharu Suzuki; Yujiro Hayashi; Noboru Murakami
Central and peripheral des-acyl ghrelin regulates body temperature in rats.
Biochemical and biophysical research communications 2013;430(1):278-83.
2013: Masayasu Kojima; Kenji Kangawa
Ghrelin discovery: a decade after.
Endocrine development 2013;25():1-4.
2013: Toshio Nishikimi; Naoko Ogawa; Hiroyuki Okamoto; Chinatsu Yamada; Kazukiyo Horii; Kenji Kangawa; Hideyuki Kinoshita; Yoshihiro Kuwabara; Koichiro Kuwahara; Izuru Masuda; Takeya Minami; Naoto Minamino; Kiyoshi Nagata; Yasuaki Nakagawa; Masahiro Nakamura; Kazuhiro Nakao; Kazuwa Nakao
Direct immunochemiluminescent assay for proBNP and total BNP in human plasma proBNP and total BNP levels in normal and heart failure.
PloS one 2013;8(1):e53233.
2013: Sayaka Akieda-Asai; Fumiyo Aoyama; Mayumi Furuya; Yoshiyuki Hizukuri; Kenji Kangawa; Shuichi Koda; Mikiya Miyazato; Takashi Miyazawa; Eri Mutoh; Atsushi Okamoto; Ichiro Okano; Paul-Emile Poleni; Akira Sawaguchi; Kazuyo Senba; Masako Sugiyama; Kenichi Yamahara; Yukari Date
Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to a high-fat diet.
Journal of lipid research 2013;54(1):85-96.
2013: Kazuyoshi Yamamoto; Makoto Yamasaki; Yoshiyuki Fujiwara; Yuichiro Hiura; Kenji Kangawa; Hiroshi Miyata; Yasuhiro Miyazaki; Masaki Mori; Kiyokazu Nakajima; Shuji Takiguchi; Yuichiro Doki
Reduced plasma ghrelin levels on day 1 after esophagectomy: a new predictor of prolonged systemic inflammatory response syndrome.
Surgery today 2013;43(1):48-54.
2012: R Fukumori; Yoshihisa Hasegawa; Kenji Kangawa; Masayasu Kojima; T Mita; T Obitsu; Toshihisa Sugino; K Taniguchi
Effects of glucose and volatile fatty acids on blood ghrelin concentrations in calves before and after weaning.
Journal of animal science 2012;90(13):4839-45.
2012: Yunfeng Ju; Kenji Kangawa; Masafumi Kanno; Shinya Kawabe; Takehiro Matsumura; Tetsuya Mizutani; Akihiro Umezawa; Takashi Yazawa; Yoshitaka Imamichi; Kaoru Miyamoto
Nuclear receptor 5A (NR5A) family regulates 5-aminolevulinic acid synthase 1 (ALAS1) gene expression in steroidogenic cells.
Endocrinology 2012;153(11):5522-34.
2012: Masako Sugiyama; Akira Yamaki; Mayumi Furuya; Norio Inomata; Yoshiharu Minamitake; Kazuhiro Ohsuye; Kenji Kangawa
Ghrelin improves body weight loss and skeletal muscle catabolism associated with angiotensin II-induced cachexia in mice.
Regulatory peptides 2012;178(1-3):21-8.
2012: Yuichiro Hiura; Kenji Kangawa; Yukinori Kurokawa; Hiroshi Miyata; Masaki Mori; Kiyokazu Nakajima; Tsuyoshi Takahashi; Shuji Takiguchi; Kazuyoshi Yamamoto; Makoto Yamasaki; Yoshiyuki Fujiwara; Yuichiro Doki
Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients: a prospective, randomized, placebo-controlled phase 2 study.
Cancer 2012;118(19):4785-94.
2012: Makiko Ohshima; Kentaro Otani; Akihiko Taguchi; Hidetoshi Tsuda; Kenichi Yamahara; Jun Yoshimatsu; Shin Ishikane; Kenji Kangawa; Shinji Katsuragi; Makoto Kodama; Mikiya Miyazato; Kazuhiko Harada; Tomoaki Ikeda
Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditis.
Journal of molecular and cellular cardiology 2012;53(3):420-8.
2012: Hiroki Saito; Sayaka Nagata; Ryuji Ikeda; Kazuhiko Inoue; Kenji Kangawa; Kazuo Kitamura; Naoto Minamino; Atsuro Miyata
Neuromedin B stimulates proliferation of mouse chondrogenic cell line ATDC5.
Peptides 2012;36(2):299-302.
2012: Yuanjie Mao; Mikiya Miyazato; Michio Nakanishi; Kentaro Otani; Takeshi Tokudome; Hiroshi Hosoda; Ichiro Kishimoto; Kenji Kangawa
Ghrelin prevents incidence of malignant arrhythmia after acute myocardial infarction through vagal afferent nerves.
Endocrinology 2012;153(7):3426-34.
2012: Daryl O Schwenke; Mikiyasu Shirai; Takeshi Tokudome; Patricia A Cragg; Takeshi Horio; Ichiro Kishimoto; Kenji Kangawa
One dose of ghrelin prevents the acute and sustained increase in cardiac sympathetic tone after myocardial infarction.
Endocrinology 2012;153(5):2436-43.
2012: Shuji Takiguchi; Kazuyoshi Yamamoto; Makoto Yamasaki; Shinichi Adachi; Kenji Kangawa; Hiroshi Miyata; Masaki Mori; Eiichi Morii; Kiyokazu Nakajima; Yuichiro Doki
Mapping analysis of ghrelin producing cells in the human stomach associated with chronic gastritis and early cancers.
Digestive diseases and sciences 2012;57(5):1238-46.
2012: J Hino; M Miyazato; T Miyazawa; Kenji Kangawa
Bone morphogenetic protein-3b (BMP-3b) is expressed in adipocytes and inhibits adipogenesis as a unique complex.
International journal of obesity (2005) 2012;36(5):725-34.
2012: Takashi Akamizu; Kenji Kangawa
The physiological significance and potential clinical applications of ghrelin.
European journal of internal medicine 2012;23(3):197-202.
2012: Eisuke Iwasaki; Kenji Kangawa; Tatsuhiro Masaoka; Toshihiro Nishizawa; Hidekazu Suzuki; Hiroshi Hosoda; Toshifumi Hibi
Enhanced gastric ghrelin production and secretion in rats with gastric outlet obstruction.
Digestive diseases and sciences 2012;57(4):858-64.
2012: Hiroharu Mifune; Yoshihiro Nishi; Yuji Tajiri; Hiroshi Hosoda; Kenji Kangawa; Taku Masuyama; Masayasu Kojima
Increased production of active ghrelin is relevant to hyperphagia in nonobese spontaneously diabetic Torii rats.
Metabolism: clinical and experimental 2012;61(4):491-5.
2012: Yoshinori Matsumoto; Mikiya Miyazato; Tomoko Miyoshi; Fumio Otsuka; Mariko Takano; Jun Hino; Hirofumi Makino; Kenji Kangawa
Bone morphogenetic protein-3b (BMP-3b) inhibits osteoblast differentiation via Smad2/3 pathway by counteracting Smad1/5/8 signaling.
Molecular and cellular endocrinology 2012;350(1):78-86.
2012: Mika Bando; Hiroshi Hosoda; Kiminori Hosoda; Hiroshi Iwakura; Kenji Kangawa; Kazuwa Nakao; Go Yamada; Souichi Adachi; Hiroyuki Ariyasu; Takashi Akamizu
Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivo.
American journal of physiology. Endocrinology and metabolism 2012;302(4):E403-8.
2012: Naomi Morozumi; Norio Ohnuma; Kazuhiro Ohsuye; Seiji Sato; Akira Yamaki; Sayaka Yoshida; Mayumi Furuya; Norio Inomata; Yoshiharu Minamitake; Kenji Kangawa
A new strategy for metabolic stabilization of motilin using the C-terminal part of ghrelin.
Peptides 2012;33(2):279-84.
2012: Sachiko Mogami; Hidekazu Suzuki; Seiichiro Fukuhara; Kenji Kangawa; Juntaro Matsuzaki; Toshifumi Hibi
Reduced ghrelin production induced anorexia after rat gastric ischemia and reperfusion.
American journal of physiology. Gastrointestinal and liver physiology 2012;302(3):G359-64.
2012: Takashi Akamizu; Hiroyuki Ariyasu; Hiroshi Hosoda; Hiroshi Iwakura; Akira Ohtake; Nobuo Sakura; Yosuke Shigematsu; Go Tajima; Kenji Kangawa
Analysis of plasma ghrelin in patients with medium-chain acyl-CoA dehydrogenase deficiency and glutaric aciduria type II.
European journal of endocrinology / European Federation of Endocrine Societies 2012;166(2):235-40.
2012: Takahiro Sato; Yuki Shiimura; Kenji Kangawa; Yuki Nakamura; Hideko Ohgusu; Masayasu Kojima
Structure, regulation and function of ghrelin.
Journal of biochemistry 2012;151(2):119-28.
2012: Takanori Ida; Kenji Kangawa; Johji Kato; Tetsutaro Hiraguchi; Kazuhiko Kume; Mikiya Miyazato; Kenji Mori; Noboru Murakami; Yuki Nakamura; Mamiko Ozaki; Hiroko Sano; Takahiro Sato; Hajime Shiotani; Tomoko Takahashi; Saki Terajima; Hatsumi Tominaga; Morikatsu Yoshida; Masayasu Kojima
Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors.
Frontiers in endocrinology 2012;3():177.
2012: Miwa Mori; Takahiro Sato; Takanori Ida; Masayasu Kojima; Mikiya Miyazato; Kenji Mori; Kenji Kangawa
Different distribution of neuromedin S and its mRNA in the rat brain: NMS peptide is present not only in the hypothalamus as the mRNA, but also in the brainstem.
Frontiers in endocrinology 2012;3():152.
2012: Masayasu Kojima; Kenji Kangawa
Methods in Enzymology. Ghrelin. Preface.
Methods in enzymology 2012;514():xxi.
2012: Mari Hotta; Rina Ohwada; Tamotsu Shibasaki; Takashi Akamizu; Kenji Kangawa
Therapeutic potential of ghrelin in restricting-type anorexia nervosa.
Methods in enzymology 2012;514():381-98.
2012: Hiroyuki Ariyasu; Hiroshi Iwakura; Kenji Kangawa; Takashi Akamizu; Go Yamada; Kazuwa Nakao
Transgenic mice overexpressing ghrelin or ghrelin analog.
Methods in enzymology 2012;514():371-7.
2012: Hiroshi Hosoda; Kenji Kangawa
Standard sample collections for blood ghrelin measurements.
Methods in enzymology 2012;514():113-26.
2012: Hiroyuki Kaiya; Kenji Kangawa; Hiroshi Hosoda; Mikiya Miyazato
Determination of nonmammalian ghrelin.
Methods in enzymology 2012;514():75-87.
2012: Masayasu Kojima; Hiroshi Hosoda; Kenji Kangawa
Purification of rat and human ghrelins.
Methods in enzymology 2012;514():45-61.
2012: Morikatsu Yoshida; Mikiya Miyazato; Kenji Kangawa
Orphan GPCRs and methods for identifying their ligands.
Methods in enzymology 2012;514():33-44.
2012: Keisuke Miki; Mari Miki; Shinsuke Murakami; Noritoshi Nagaya; Masamitsu Nakazato; Shunsuke Ohnishi; Yoshitaka Tateishi; Kenichi Yamahara; Masanori Yoshikawa; Kenji Yoshimura; Hiroshi Kimura; Seigo Kitada; Ryoji Maekura; Nobuhiro Matsumoto; Yasuji Arimura; Toru Hiraga; Kenji Kangawa
Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: a multicenter, randomized, double-blind, placebo-controlled trial.
PloS one 2012;7(5):e35708.
2012: Naokazu Hamada; Hiroshi Hosoda; Ryozo Kamimura; Kenji Kangawa; Masayasu Kojima; Kenkichi Miyahara; Yoshihiro Nishi; Norihito Nuruki; Kentaro Setoyama; Yuji Tajiri; Hiroharu Mifune
Disrupted regulation of ghrelin production under antihypertensive treatment in spontaneously hypertensive rats.
Circulation journal : official journal of the Japanese Circulation Society 2012;76(6):1423-9.
2011: Yoshifumi Imazu; Kenji Kangawa; Nobuhiro Matsumoto; Kahori Miyoshi; Hironobu Tsubouchi; Shu-Ichi Yamashita; Shigehisa Yanagi; Jun-ichi Ashitani; Masamitsu Nakazato
Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation.
European journal of pharmacology 2011;672(1-3):153-8.
2011: Shintaro Yamaguchi; Kenichi Yamahara; Shizuka Fujii; Koichiro Homma; Kenji Kangawa; Yumi Matsuzaki; Toshiaki Monkawa; Ryuji Morizane; Sayuri Suzuki; Hiroshi Itoh
The role of microRNA-145 in human embryonic stem cell differentiation into vascular cells.
Atherosclerosis 2011;219(2):468-74.
2011: Munetsugu Hara; Hiroshi Hosoda; Tatsuyuki Kakuma; Kenji Kangawa; Masayasu Kojima; Shinichiro Nagamitsu; Yoshihiro Nishi; Satoru Takahashi; Yushiro Yamashita; Junko Yoh; Toyojiro Matsuishi
Ghrelin levels are reduced in Rett syndrome patients with eating difficulties.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2011;29(8):899-902.
2011: Masayasu Kojima; Kenji Kangawa
The discovery of ghrelin: with a little luck and great passion. Preface.
Peptides 2011;32(11):2153-4.
2011: Takashi Akamizu; Kenji Kangawa
Therapeutic applications of ghrelin to cachexia utilizing its appetite-stimulating effect.
Peptides 2011;32(11):2295-300.
2011: Hiroyuki Kaiya; Mikiya Miyazato; Kenji Kangawa
Recent advances in the phylogenetic study of ghrelin.
Peptides 2011;32(11):2155-74.
2011: Takanori Ida; Kenji Kangawa; Johji Kato; Kazuhiko Kume; Mikiya Miyazato; Noboru Murakami; Hideki Nishio; Takahiro Sato; Tomoko Takahashi; Hatsumi Tominaga; Kumiko Yoshizawa-Kumagaye; Masayasu Kojima
Identification of the endogenous cysteine-rich peptide trissin, a ligand for an orphan G protein-coupled receptor in Drosophila.
Biochemical and biophysical research communications 2011;414(1):44-8.
2011: Keisei Ikeda; Kenji Kangawa; Tamotsu Sugai; Toshimi Chiba; Hiroshi Hosoda; Kazuyuki Suzuki
Correlation between plasma or mucosal ghrelin levels and chronic gastritis.
Hepato-gastroenterology 2011;58(110-111):1622-7.
2011: Daryl O Schwenke; Takashi Sonobe; Keiji Umetani; Isabel Campillo; Emily A Gray; Hatsue Ishibashi-Ueda; Kenji Kangawa; James T Pearson; Mikiyasu Shirai
Exogenous ghrelin improves blood flow distribution in pulmonary hypertension-assessed using synchrotron radiation microangiography.
Pflügers Archiv : European journal of physiology 2011;462(3):397-406.
2011: Takanori Ida; Kenji Kangawa; Johji Kato; Tetsutaro Hiraguchi; Kazuhiko Kume; Toru Maeda; Mikiya Miyazato; Kenji Mori; Noboru Murakami; Mamiko Ozaki; Hiroko Sano; Takahiro Sato; Hajime Shiotani; Tomoko Takahashi; Saki Terajima; Hatsumi Tominaga; Morikatsu Yoshida; Masayasu Kojima
Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila.
Biochemical and biophysical research communications 2011;410(4):872-7.
2011: Shuji Shimizu; Mikiyasu Shirai; Toshiaki Shishido; Takashi Sonobe; Tsuyoshi Akiyama; Hiroshi Hosoda; Atsunori Kamiya; Kenji Kangawa; Toru Kawada; Takeshi Tokudome; Masaru Sugimachi
Centrally administered ghrelin activates cardiac vagal nerve in anesthetized rabbits.
Autonomic neuroscience : basic & clinical 2011;162(1-2):60-5.
2011: R Fukumori; Yoshihisa Hasegawa; Kenji Kangawa; Masayasu Kojima; T Obitsu; Toshihisa Sugino; K Taniguchi
Plasma ghrelin concentration is decreased by short chain fatty acids in wethers.
Domestic animal endocrinology 2011;41(1):50-5.
2011: Hiroshi Iwakura; Kenji Kangawa; Kazuwa Nakao; Go Yamada; Hiroyuki Ariyasu; Hiroshi Hosoda; Kiminori Hosoda; Takashi Akamizu
Oxytocin and dopamine stimulate ghrelin secretion by the ghrelin-producing cell line, MGN3-1 in vitro.
Endocrinology 2011;152(7):2619-25.
2011: Kazuhiko Harada; Kenichi Yamahara; Shunsuke Ohnishi; Kentaro Otani; Hirohisa Kanoh; Hatsue Ishibashi-Ueda; Naoto Minamino; Kenji Kangawa; Noritoshi Nagaya; Tomoaki Ikeda
Sustained-release adrenomedullin ointment accelerates wound healing of pressure ulcers.
Regulatory peptides 2011;168(1-3):21-6.
2011: Ichiro Kishimoto; Takeshi Tokudome; Kazuwa Nakao; Kenji Kangawa
Natriuretic peptide system: an overview of studies using genetically engineered animal models.
The FEBS journal 2011;278(11):1830-41.
2011: Takumi Sakamoto; Keiko Nakahara; Keisuke Maruyama; Tetsuro Katayama; Kenji Mori; Mikiya Miyazato; Kenji Kangawa; Noboru Murakami
Neuromedin S regulates cardiovascular function through the sympathetic nervous system in mice.
Peptides 2011;32(5):1020-6.
2011: Naomi Morozumi; Takeshi Hanada; Hiromi Habara; Akira Yamaki; Mayumi Furuya; Takashi Nakatsuka; Norio Inomata; Yoshiharu Minamitake; Kazuhiro Ohsuye; Kenji Kangawa
The role of C-terminal part of ghrelin in pharmacokinetic profile and biological activity in rats.
Peptides 2011;32(5):1001-7.
2011: Rika Fukumori; Yoshihisa Hasegawa; Fumiaki Itoh; Kenji Kangawa; Masayasu Kojima; Shiro Kushibiki; Naoko Moriya; Taketo Obitsu; Hiroyuki Shingu; Toshihisa Sugino; Akinori Yokotani; Kohzo Taniguchi
Effects of amino acids infused into the vein on ghrelin-induced GH, insulin and glucagon secretion in lactating cows.
Animal science journal = Nihon chikusan Gakkaihō 2011;82(2):267-73.
2011: Masaru Koizumi; Yoshinori Hosoya; Katsuya Dezaki; Toshihiko Yada; Hiroshi Hosoda; Kenji Kangawa; Hideo Nagai; Alan T Lefor; Naohiro Sata; Yoshikazu Yasuda
Postoperative weight loss does not resolve after esophagectomy despite normal serum ghrelin levels.
The Annals of thoracic surgery 2011;91(4):1032-7.
2011: Ichiro Okano; Mikiya Miyazato; Kenji Kangawa
A guanosine 3',5'-cyclic monophosphate (cGMP) reporter system based on the G-kinase/CREB/CRE signal transduction pathway.
Biochemical and biophysical research communications 2011;407(1):236-41.
2011: Daryl O Schwenke; James T Pearson; Takashi Sonobe; Hatsue Ishibashi-Ueda; Akito Shimouchi; Kenji Kangawa; Keiji Umetani; Mikiyasu Shirai
Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension.
Journal of applied physiology (Bethesda, Md. : 1985) 2011;110(4):901-8.
2011: Junko Yoh; Yoshihiro Nishi; Hiroshi Hosoda; Yuji Tajiri; Kentaro Yamada; Toshihiko Yanase; Ryosuke Doi; Koji Yonemoto; Kenji Kangawa; Masayasu Kojima; Eiichiro Tanaka; Jingo Kusukawa
Plasma levels of n-decanoyl ghrelin, another acyl- and active-form of ghrelin, in human subjects and the effect of glucose- or meal-ingestion on its dynamics.
Regulatory peptides 2011;167(1):140-8.
2011: Donghao Jin; Kentaro Otani; Kenichi Yamahara; Tomoaki Ikeda; Noritoshi Nagaya; Kenji Kangawa
Adrenomedullin reduces expression of adhesion molecules on lymphatic endothelial cells.
Regulatory peptides 2011;166(1-3):21-7.
2011: Hiroyuki Kaiya; Kenji Kangawa; Yasushi Koizumi; Norifumi Konno; Minoru Uchiyama; Kazutoshi Yamamoto; Mikiya Miyazato
Ghrelin Receptor in Two Species of Anuran Amphibian, Bullfrog (Rana catesbeiana), and Japanese Tree Frog (Hyla japonica).
Frontiers in endocrinology 2011;2():31.
2011: Yongheng Cao; Yoshitake Hayashi; Yukio Hirata; Hiroshi Hosoda; Kristy Iskandar; Hiroshi Itoh; Kenji Kangawa; Masato Kasuga; Yasuhiko Minokoshi; Kazunori Nakajima; Masanori Nakata; Tetsuo Noda; Wataru Ogawa; Shiki Okamoto; Eisuke Takano; Toshihiko Yada; Gregory S Barsh; Jun Nakae
PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure.
PloS one 2011;6(4):e18324.
2011: Tomomi Shiiya; Hiroaki Ueno; Koji Toshinai; Takashi Kawagoe; Seiko Naito; Takuro Tobina; Yuichiro Nishida; Munehiro Shindo; Kenji Kangawa; Hiroaki Tanaka; Masamitsu Nakazato
Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men.
Endocrine journal 2011;58(5):335-42.
2010: Go Yamada; Hiroyuki Ariyasu; Hiroshi Iwakura; Hiroshi Hosoda; Takashi Akamizu; Kazuwa Nakao; Kenji Kangawa
Generation of transgenic mice overexpressing a ghrelin analog.
Endocrinology 2010;151(12):5935-40.
2010: Hidetoshi Tsuda; Kenichi Yamahara; Shin Ishikane; Kentaro Otani; Atsuhiro Nakamura; Kazutomo Sawai; Naotsugu Ichimaru; Masaharu Sada; Akihiko Taguchi; Hiroshi Hosoda; Masahiro Tsuji; Hiroshi Kawachi; Masaru Horio; Yoshitaka Isaka; Kenji Kangawa; Shiro Takahara; Tomoaki Ikeda
Allogenic fetal membrane-derived mesenchymal stem cells contribute to renal repair in experimental glomerulonephritis.
American journal of physiology. Renal physiology 2010;299(5):F1004-13.
2010: Keiko Nakahara; Tetsuro Katayama; Keisuke Maruyama; Takanori Ida; Kenji Mori; Mikiya Miyazato; Kenji Kangawa; Noboru Murakami
Comparison of feeding suppression by the anorexigenic hormones neuromedin U and neuromedin S in rats.
The Journal of endocrinology 2010;207(2):185-93.
2010: Shin Ishikane; Kenichi Yamahara; Masaharu Sada; Kazuhiko Harada; Makoto Kodama; Hatsue Ishibashi-Ueda; Kazuhide Hayakawa; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara; Kenji Kangawa; Tomoaki Ikeda
Allogeneic administration of fetal membrane-derived mesenchymal stem cells attenuates acute myocarditis in rats.
Journal of molecular and cellular cardiology 2010;49(5):753-61.
2010: Mina Ushiyama; Ryuji Ikeda; Morikatsu Yoshida; Kenji Mori; Kenji Kangawa; Hideki Sugawara; Kazuhiko Inoue; Katsushi Yamada; Atsuro Miyata
Alternative splicing of the pituitary adenylate cyclase-activating polypetide (PACAP) receptor contributes to function of PACAP-27.
Journal of molecular neuroscience : MN 2010;42(3):341-8.
2010: Daryl O Schwenke; James T Pearson; Kenji Kangawa; P A Cragg; Mikiyasu Shirai
Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats.
Acta physiologica (Oxford, England) 2010;200(3):279-87.
2010: Hiroyuki Kaiya; Tohru Miura; Kouhei Matsuda; Mikiya Miyazato; Kenji Kangawa
Two functional growth hormone secretagogue receptor (ghrelin receptor) type 1a and 2a in goldfish, Carassius auratus.
Molecular and cellular endocrinology 2010;327(1-2):25-39.
2010: Yu Kataoka; Shunichi Miyazaki; Satoshi Yasuda; Noritoshi Nagaya; Teruo Noguchi; Naoaki Yamada; Isao Morii; Atsushi Kawamura; Kaori Doi; Kunio Miyatake; Hitonobu Tomoike; Kenji Kangawa
The first clinical pilot study of intravenous adrenomedullin administration in patients with acute myocardial infarction.
Journal of cardiovascular pharmacology 2010;56(4):413-9.
2010: Keiko Nakahara; Rieko Okame; Tetsuro Katayama; Mikiya Miyazato; Kenji Kangawa; Noboru Murakami
Nutritional and environmental factors affecting plasma ghrelin and leptin levels in rats.
The Journal of endocrinology 2010;207(1):95-103.
2010: Takanori Ida; Mikiya Miyazato; Xing-Zi Lin; Hiroyuki Kaiya; Takahiro Sato; Keiko Nakahara; Noboru Murakami; Kenji Kangawa; Masayasu Kojima
Purification and characterization of caprine ghrelin and its effect on growth hormone release.
Journal of molecular neuroscience : MN 2010;42(1):99-105.
2010: Hiroshi Hosoda; Kenji Kangawa
[Ghrelin measurement].
Nihon rinsho. Japanese journal of clinical medicine 2010;68 Suppl 7():524-8.
2010: Masayasu Kojima; Kenji Kangawa
Ghrelin: more than endogenous growth hormone secretagogue.
Annals of the New York Academy of Sciences 2010;1200():140-8.
2010: Yoshiki Nakashima; Takanori Ida; Takahiro Sato; Yuki Nakamura; Tomoko Takahashi; Kenji Mori; Mikiya Miyazato; Kenji Kangawa; Jingo Kusukawa; Masayasu Kojima
Neuromedin U is necessary for normal gastrointestinal motility and is regulated by serotonin.
Annals of the New York Academy of Sciences 2010;1200():104-11.
2010: Kazuyoshi Yamamoto; Shuji Takiguchi; Hiroshi Miyata; Shinichi Adachi; Yuichiro Hiura; Makoto Yamasaki; Kiyokazu Nakajima; Yoshiyuki Fujiwara; Masaki Mori; Kenji Kangawa; Yuichiro Doki
Randomized phase II study of clinical effects of ghrelin after esophagectomy with gastric tube reconstruction.
Surgery 2010;148(1):31-8.
2010: Hiroshi Iwakura; Yushu Li; Hiroyuki Ariyasu; Hiroshi Hosoda; Naotetsu Kanamoto; Mika Bando; Go Yamada; Kiminori Hosoda; Kazuwa Nakao; Kenji Kangawa; Takashi Akamizu
Establishment of a novel ghrelin-producing cell line.
Endocrinology 2010;151(6):2940-5.
2010: H Takahashi; Yohei Kurose; Y Suzuki; Masayasu Kojima; T Yamaguchi; Y Yoshida; Y Azuma; Toshihisa Sugino; M Kojima; Kenji Kangawa; Yoshihisa Hasegawa; Shigeki Kobayashi
Changes in blood pancreatic polypeptide and ghrelin concentrations in response to feeding in sheep.
Journal of animal science 2010;88(6):2103-7.
2010: Toshihisa Sugino; Yuko Kawakita; Rika Fukumori; Yoshihisa Hasegawa; Masayasu Kojima; Kenji Kangawa; Taketo Obitsu; Kohzo Taniguchi
Effects of glucose and amino acids on ghrelin secretion in sheep.
Animal science journal = Nihon chikusan Gakkaihō 2010;81(2):199-204.
2010: Hiroyuki Ariyasu; Hiroshi Iwakura; Go Yamada; Naotetsu Kanamoto; Mika Bando; Kenji Kohno; Takahiro Sato; Masayasu Kojima; Kazuwa Nakao; Kenji Kangawa; Takashi Akamizu
A postweaning reduction in circulating ghrelin temporarily alters growth hormone (GH) responsiveness to GH-releasing hormone in male mice but does not affect somatic growth.
Endocrinology 2010;151(4):1743-50.
2010: Shinichi Adachi; Shuji Takiguchi; Kazuyuki Okada; Kazuyoshi Yamamoto; Makoto Yamasaki; Hiroshi Miyata; Kiyokazu Nakajima; Yoshiyuki Fujiwara; Hiroshi Hosoda; Kenji Kangawa; Masaki Mori; Yuichiro Doki
Effects of ghrelin administration after total gastrectomy: a prospective, randomized, placebo-controlled phase II study.
Gastroenterology 2010;138(4):1312-20.
2010: Yoshiyuki Inoue; Keiko Nakahara; Kenji Kangawa; Noboru Murakami
Transitional change in rat fetal cell proliferation in response to ghrelin and des-acyl ghrelin during the last stage of pregnancy.
Biochemical and biophysical research communications 2010;393(3):455-60.
2010: S Goto; K Nagao; M Bannai; M Takahashi; Keiko Nakahara; Kenji Kangawa; Noboru Murakami
Anorexia in rats caused by a valine-deficient diet is not ameliorated by systemic ghrelin treatment.
Neuroscience 2010;166(1):333-40.
2010: Takashi Akamizu; Hiroshi Iwakura; Hiroyuki Ariyasu; Kenji Kangawa
Ghrelin and functional dyspepsia.
International journal of peptides 2010;2010():.
2010: Masaru Koizumi; Katsuya Dezaki; Hiroshi Hosoda; Boldbaatar Damdindorj; Hideyuki Sone; Lu Ming; Yoshinori Hosoya; Naohiro Sata; Eiji Kobayashi; Kenji Kangawa; Hideo Nagai; Yoshikazu Yasuda; Toshihiko Yada
Reconstruction-dependent recovery from anorexia and time-related recovery of regulatory ghrelin system in gastrectomized rats.
International journal of peptides 2010;2010():.
2010: Hiromitsu Shinozaki; Hiroshi Aoki; Yoshimitsu Kasahara; Kenji Kangawa; Takashi Minegishi
Plasma adrenomedullin levels during multiple pregnancy.
Gynecologic and obstetric investigation 2010;69(3):169-73.
2010: Masayasu Kojima; Kenji Kangawa
Ghrelin: from gene to physiological function.
Results and problems in cell differentiation 2010;50():185-205.
2009: Itaru Kyoraku; Kazutaka Shiomi; Kenji Kangawa; Masamitsu Nakazato
Ghrelin reverses experimental diabetic neuropathy in mice.
Biochemical and biophysical research communications 2009;389(3):405-8.
2009: Takeshi Tokudome; Ichiro Kishimoto; Kenichi Yamahara; Tsukasa Osaki; Naoto Minamino; Takeshi Horio; Kazutomo Sawai; Yuhei Kawano; Mikiya Miyazato; Masataka Sata; Masakazu Kohno; Kazuwa Nakao; Kenji Kangawa
Impaired recovery of blood flow after hind-limb ischemia in mice lacking guanylyl cyclase-A, a receptor for atrial and brain natriuretic peptides.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(10):1516-21.
2009: Hiroshi Iwakura; Hiroyuki Ariyasu; Yushu Li; Naotetsu Kanamoto; Mika Bando; Go Yamada; Hiroshi Hosoda; Kiminori Hosoda; Akira Shimatsu; Kazuwa Nakao; Kenji Kangawa; Takashi Akamizu
A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance.
American journal of physiology. Endocrinology and metabolism 2009;297(3):E802-11.
2009: Hiroyuki Kaiya; Mitsuhiro Furuse; Mikiya Miyazato; Kenji Kangawa
Current knowledge of the roles of ghrelin in regulating food intake and energy balance in birds.
General and comparative endocrinology 2009;163(1-2):33-8.
2009: Michael-Mark Theil; Sachiko Miyake; Miho Mizuno; Chiharu Tomi; J. Ludovic Croxford; Hiroshi Hosoda; Julia Theil; Stephan von Hörsten; Hiroaki Yokote; Asako Chiba; Youwei Lin; Shinji Oki; Takashi Akamizu; Kenji Kangawa; Takashi Yamamura
Suppression of experimental autoimmune encephalomyelitis by ghrelin.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2859-66.
2009: Hiroshi Hiejima; Yoshihiro Nishi; Hiroshi Hosoda; Junko Yoh; Hiroharu Mifune; Motoyasu Satou; Hiroyuki Sugimoto; Seiichi Chiba; Yukie Kawahara; Eiichiro Tanaka; Hironobu Yoshimatsu; Naohisa Uchimura; Kenji Kangawa; Masayasu Kojima
Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents.
Regulatory peptides 2009;156(1-3):47-56.
2009: Hiroyuki Kaiya; Tsukasa Mori; Mikiya Miyazato; Kenji Kangawa
Ghrelin receptor (GHS-R)-like receptor and its genomic organisation in rainbow trout, Oncorhynchus mykiss.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2009;153(4):438-50.
2009: Daryl O Schwenke; James T Pearson; Akito Shimochi; Kenji Kangawa; Hirotsugu Tsuchimochi; Keiji Umetani; Mikiyasu Shirai; Patricia A Cragg
Changes in pulmonary blood flow distribution in monocrotaline compared with hypoxia-induced models of pulmonary hypertension: assessed using synchrotron radiation.
Journal of hypertension 2009;27(7):1410-9.
2009: H Takahashi; Yohei Kurose; Y Suzuki; M Kojima; T Yamaguchi; Y Yoshida; M Ogino; K Hodate; Y Azuma; Toshihisa Sugino; Masayasu Kojima; Kenji Kangawa; Yoshihisa Hasegawa; Shigeki Kobayashi
Ghrelin differentially modulates the GH secretory response to GHRH between the fed and fasted states in sheep.
Domestic animal endocrinology 2009;37(1):55-60.
2009: Mariko Harada-Shiba; Itaru Takamisawa; Kanjiro Miyata; Takehiko Ishii; Nobuhiro Nishiyama; Keiji Itaka; Kenji Kangawa; Fumiki Yoshihara; Yujiro Asada; Kinta Hatakeyama; N Nagaya; Kazunori Kataoka
Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(7):1180-6.
2009: Yuichiro Yano; Koji Toshinai; Takashi Inokuchi; Kenji Kangawa; Kazuyuki Shimada; Kazuomi Kario; Masamitsu Nakazato
Plasma des-acyl ghrelin, but not plasma HMW adiponectin, is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensive patients.
Atherosclerosis 2009;204(2):590-4.
2009: Hiroyuki Kaiya; Larry G Riley; Whitney Janzen; Tetsuya Hirano; E Gordon Grau; Mikiya Miyazato; Kenji Kangawa
Identification and genomic sequence of a ghrelin receptor (GHS-R)-like receptor in the Mozambique tilapia, Oreochromis mossambicus.
Zoological science 2009;26(5):330-7.
2009: Toshio Nishikimi; Tsuyoshi Karasawa; Chikako Inaba; Kimihiko Ishimura; Kazuyoshi Tadokoro; Shogo Koshikawa; Fumiki Yoshihara; Noritoshi Nagaya; Hideaki Sakio; Kenji Kangawa; Hiroaki Matsuoka
Effects of long-term intravenous administration of adrenomedullin (AM) plus hANP therapy in acute decompensated heart failure: a pilot study.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(5):892-8.
2009: Tohru Miura; Keisuke Maruyama; Hiroyuki Kaiya; Mikiya Miyazato; Kenji Kangawa; Minoru Uchiyama; Seiji Shioda; Kouhei Matsuda
Purification and properties of ghrelin from the intestine of the goldfish, Carassius auratus.
Peptides 2009;30(4):758-65.
2009: K Yamahara; K D Min; Hitonobu Tomoike; Kenji Kangawa; S Kitamura; Noritoshi Nagaya
Pathological role of angiostatin in heart failure: an endogenous inhibitor of mesenchymal stem-cell activation.
Heart (British Cardiac Society) 2009;95(4):283-9.
2009: Ichiro Kishimoto; Takeshi Tokudome; Takeshi Horio; David L Garbers; Kazuwa Nakao; Kenji Kangawa
Natriuretic Peptide Signaling via Guanylyl Cyclase (GC)-A: An Endogenous Protective Mechanism of the Heart.
Current cardiology reviews 2009;5(1):45-51.
2009: Kenji Kangawa
Challenge for novel peptide hormones: from discovery to therapeutic application.
Endocrine journal 2009;56(9):1031-2.
2009: Hiroyuki Kaiya; Shiho Kodama; Koutaro Ishiguro; Kouhei Matsuda; Minoru Uchiyama; Mikiya Miyazato; Kenji Kangawa
Ghrelin-like peptide with fatty acid modification and O-glycosylation in the red stingray, Dasyatis akajei.
BMC biochemistry 2009;10():30.
2009: Mari Hotta; Rina Ohwada; Takashi Akamizu; Tamotsu Shibasaki; Kazue Takano; Kenji Kangawa
Ghrelin increases hunger and food intake in patients with restricting-type anorexia nervosa: a pilot study.
Endocrine journal 2009;56(9):1119-28.
2009: Haruko Masumiya; Yasuhide Asaumi; Miyuki Nishi; Susumu Minamisawa; Satomi Adachi-Akahane; Morikatsu Yoshida; Kenji Kangawa; Kenta Ito; Yutaka Kagaya; Teruyuki Yanagisawa; Tetsuo Yamazaki; Jianjie Ma; Hiroshi Takeshima
Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes.
Channels (Austin, Tex.) 2009;3(1):6-11.
2008: Eisuke Iwasaki; Hidekazu Suzuki; Yoshinori Sugino; Tsutomu Iida; Toshihiro Nishizawa; Tatsuhiro Masaoka; Hiroshi Hosoda; Kenji Kangawa; Toshifumi Hibi
Decreased levels of adiponectin in obese patients with gastroesophageal reflux evaluated by videoesophagography: possible relationship between gastroesophageal reflux and metabolic syndrome.
Journal of gastroenterology and hepatology 2008;23 Suppl 2():S216-21.
2008: Hiroshi Iwakura; Hiroyuki Ariyasu; Naotetsu Kanamoto; Kiminori Hosoda; Kazuwa Nakao; Kenji Kangawa; Takashi Akamizu
Establishment of a novel neuroblastoma mouse model.
International journal of oncology 2008;33(6):1195-9.
2008: Donghao Jin; Kazuhiko Harada; Shunsuke Ohnishi; Kenich Yamahara; Kenji Kangawa; Noritoshi Nagaya
Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema.
Cardiovascular research 2008;80(3):339-45.
2008: Ken-ichi Takahashi; Kazuo Chin; Takashi Akamizu; Satoshi Morita; Kensuke Sumi; Toru Oga; Hisako Matsumoto; Akio Niimi; Tomomasa Tsuboi; Shunichi Fukuhara; Kenji Kangawa; Michiaki Mishima
Acylated ghrelin level in patients with OSA before and after nasal CPAP treatment.
Respirology (Carlton, Vic.) 2008;13(6):810-6.
2008: Ichiro Kishimoto; Takeshi Tokudome; Takeshi Horio; Takeshi Soeki; H Chusho; Kazuwa Nakao; Kenji Kangawa
C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurones.
Journal of neuroendocrinology 2008;20(11):1213-23.
2008: Takumi Sakamoto; Kenji Mori; Mikiya Miyazato; Kenji Kangawa; Hiroshi Sameshima; Keiko Nakahara; Noboru Murakami
Involvement of neuromedin S in the oxytocin release response to suckling stimulus.
Biochemical and biophysical research communications 2008;375(1):49-53.
2008: Daryl O Schwenke; Takeshi Tokudome; Ichiro Kishimoto; Takeshi Horio; Mikiyasu Shirai; Patricia A Cragg; Kenji Kangawa
Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality.
Endocrinology 2008;149(10):5172-6.
2008: Tsuyoshi Kodama; Jun-ichi Ashitani; Nobuhiro Matsumoto; Kenji Kangawa; Masamitsu Nakazato
Ghrelin treatment suppresses neutrophil-dominant inflammation in airways of patients with chronic respiratory infection.
Pulmonary pharmacology & therapeutics 2008;21(5):774-9.
2008: Kaori Fukumoto; Keiko Nakahara; Tetsuro Katayama; Mikiya Miyazatao; Kenji Kangawa; Noboru Murakami
Synergistic action of gastrin and ghrelin on gastric acid secretion in rats.
Biochemical and biophysical research communications 2008;374(1):60-3.
2008: Kazuhide Tanaka; Shigeru Morinobu; Mai Ichimura; Akihiro Asakawa; Akio Inui; Hiroshi Hosoda; Kenji Kangawa; Shigeto Yamawaki
Decreased levels of ghrelin, cortisol, and fasting blood sugar, but not n-octanoylated ghrelin, in Japanese schizophrenic inpatients treated with olanzapine.
Progress in neuro-psychopharmacology & biological psychiatry 2008;32(6):1527-32.
2008: Hiroyuki Ariyasu; Hiroshi Iwakura; Go Yamada; Kazuwa Nakao; Kenji Kangawa; Takashi Akamizu
Efficacy of ghrelin as a therapeutic approach for age-related physiological changes.
Endocrinology 2008;149(7):3722-8.
2008: Takeshi Tokudome; Ichiro Kishimoto; Takeshi Horio; Yuji Arai; Daryl O Schwenke; Jun Hino; Ichiro Okano; Yuhei Kawano; Masakazu Kohno; Mikiya Miyazato; Kazuwa Nakao; Kenji Kangawa
Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart.
Circulation 2008;117(18):2329-39.
2008: Takashi Akamizu; Hiroshi Iwakura; Hiroyuki Ariyasu; Hiroshi Hosoda; Toshinori Murayama; Masayuki Yokode; Satoshi Teramukai; Hiroshi Seno; Tsutomu Chiba; Shunichi Noma; Yoshikatsu Nakai; Mikihiko Fukunaga; Yoshihide Nakai; Kenji Kangawa
Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite.
European journal of endocrinology / European Federation of Endocrine Societies 2008;158(4):491-8.
2008: Hidenori Nishida; Takeshi Horio; Yoshihiko Suzuki; Yoshio Iwashima; Kei Kamide; Kenji Kangawa; Yuhei Kawano
Plasma adrenomedullin as an independent predictor of future cardiovascular events in high-risk patients: comparison with C-reactive protein and adiponectin.
Peptides 2008;29(4):599-605.
2008: Zheng Zhao; Ichiro Sakata; Yusuke Okubo; Kanako Koike; Kenji Kangawa; Takafumi Sakai
Gastric leptin, but not estrogen and somatostatin, contributes to the elevation of ghrelin mRNA expression level in fasted rats.
The Journal of endocrinology 2008;196(3):529-38.
2008: H Piao; H Hosoda; Kenji Kangawa; Tetsuhito Murata; Kazumi Narita; Takashi Higuchi
Ghrelin stimulates milk intake by affecting adult type feeding behaviour in postnatal rats.
Journal of neuroendocrinology 2008;20(3):330-4.
2008: Hiroshi Hosoda; Kenji Kangawa
The autonomic nervous system regulates gastric ghrelin secretion in rats.
Regulatory peptides 2008;146(1-3):12-8.
2008: Hiroyuki Kaiya; Mikiya Miyazato; Kenji Kangawa; Richard E Peter; Suraj Unniappan
Ghrelin: a multifunctional hormone in non-mammalian vertebrates.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2008;149(2):109-28.
2008: Hiroaki Obata; Yoshiki Sakai; Shunsuke Ohnishi; Satoshi Takeshita; Hidezo Mori; Makoto Kodama; Kenji Kangawa; Yoshifusa Aizawa; Noritoshi Nagaya
Single injection of a sustained-release prostacyclin analog improves pulmonary hypertension in rats.
American journal of respiratory and critical care medicine 2008;177(2):195-201.
2008: Yasunori Hori; Haruaki Kageyama; Jian-Lian Guan; Daisuke Kohno; Toshihiko Yada; Fumiko Takenoya; Naoko Nonaka; Kenji Kangawa; Seiji Shioda; Takemi Yoshida
Synaptic interaction between ghrelin- and ghrelin-containing neurons in the rat hypothalamus.
Regulatory peptides 2008;145(1-3):122-7.
2008: Takahiro Sato; Mamoru Kurokawa; Yoshiki Nakashima; Takanori Ida; Tomoko Takahashi; Yoshihiko Fukue; Masahito Ikawa; Masaru Okabe; Kenji Kangawa; Masayasu Kojima
Ghrelin deficiency does not influence feeding performance.
Regulatory peptides 2008;145(1-3):7-11.
2008: Mikiya Miyazato; Kenji Mori; Takanori Ida; Masayasu Kojima; Noboru Murakami; Kenji Kangawa
Identification and functional analysis of a novel ligand for G protein-coupled receptor, Neuromedin S.
Regulatory peptides 2008;145(1-3):37-41.
2008: Milki Yokokawa; Shunsuke Ohnishi; Hatsue Ishibashi-Ueda; Hiroaki Obata; Kentaro Otani; Yoshinori Miyahara; Koichi Tanaka; Wataru Shimizu; Kazuo Nakazawa; Kenji Kangawa; Shiro Kamakura; Soichiro Kitamura; Noritoshi Nagaya
Transplantation of mesenchymal stem cells improves atrioventricular conduction in a rat model of complete atrioventricular block.
Cell transplantation 2008;17(10-11):1145-55.
2008: Yoshihiko Inaoka; Takashi Yazawa; Tetsuya Mizutani; Koichi Kokame; Kenji Kangawa; Miki Uesaka; Akihiro Umezawa; Kaoru Miyamoto
Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production.
Reproductive biology and endocrinology : RB&E 2008;6():62.
2008: Satoru Usami; Ichiro Kishimoto; Yoshihiko Saito; Masaki Harada; Koichiro Kuwahara; Yasuaki Nakagawa; Michio Nakanishi; Shinji Yasuno; Kenji Kangawa; Kazuwa Nakao
Association of CT dinucleotide repeat polymorphism in the 5'-flanking region of the guanylyl cyclase (GC)-A gene with essential hypertension in the Japanese.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(1):89-96.
2008: Kenji Mori; Mikiya Miyazato; Kenji Kangawa
Neuromedin S: discovery and functions.
Results and problems in cell differentiation 2008;46():201-12.
2008: Masayasu Kojima; Kenji Kangawa
Structure and function of ghrelin.
Results and problems in cell differentiation 2008;46():89-115.
2008: Yuka Ichikawa-Shindo; Takayuki Sakurai; Akiko Kamiyoshi; Hisaka Kawate; Nobuyoshi Iinuma; Takahiro Yoshizawa; Teruhide Koyama; Junichi Fukuchi; Satoshi Iimuro; Nobuo Moriyama; Hayato Kawakami; Toshinori Murata; Kenji Kangawa; Ryozo Nagai; Takayuki Shindo
The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity.
The Journal of clinical investigation 2008;118(1):29-39.
2008: Takeshi Soeki; Ichiro Kishimoto; Daryl O Schwenke; Takeshi Tokudome; Takeshi Horio; Morikatsu Yoshida; Hiroshi Hosoda; Kenji Kangawa
Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2008;294(1):H426-32.
2008: Daryl O Schwenke; James T Pearson; Kenji Kangawa; Keiji Umetani; Mikiyasu Shirai
Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia: assessed using synchrotron radiation microangiography.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;104(1):88-96.
2008: Daryl O Schwenke; Takeshi Tokudome; Mikiyasu Shirai; Hiroshi Hosoda; Takeshi Horio; Ichiro Kishimoto; Kenji Kangawa
Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats.
Endocrinology 2008;149(1):237-44.
2007: James T Pearson; Mikiyasu Shirai; Hirotsugu Tsuchimochi; Daryl O Schwenke; Takayuki Ishida; Kenji Kangawa; Hiroyuki Suga; Naoto Yagi
Effects of sustained length-dependent activation on in situ cross-bridge dynamics in rat hearts.
Biophysical journal 2007;93(12):4319-29.
2007: Shingo Sato; Reiko Hanada; Ayako Kimura; Tomomi Abe; Takahiro Matsumoto; Makiko Iwasaki; Hiroyuki Inose; Takanori Ida; Michihiro Mieda; Yasuhiro Takeuchi; Seiji Fukumoto; Toshiro Fujita; Shigeaki Kato; Kenji Kangawa; Masayasu Kojima; Kenichi Shinomiya; Shu Takeda
Central control of bone remodeling by neuromedin U.
Nature medicine 2007;13(10):1234-40.
2007: Kazutomo Sawai; Masashi Mukoyama; Kiyoshi Mori; Masato Kasahara; Masao Koshikawa; Hideki Yokoi; Tetsuro Yoshioka; Yoshihisa Ogawa; Akira Sugawara; Hiroyuki Nishiyama; Shigehito Yamada; Takashi Kuwahara; Moin A Saleem; Kohei Shiota; Osamu Ogawa; Mikiya Miyazato; Kenji Kangawa; Kazuwa Nakao
Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney.
American journal of physiology. Renal physiology 2007;293(4):F1363-72.
2007: Bobby Yanagawa; Masaharu Kataoka; Shunsuke Ohnishi; Makoto Kodama; Koichi Tanaka; Yoshinori Miyahara; Hatsue Ishibashi-Ueda; Yoshifusa Aizawa; Kenji Kangawa; Noritoshi Nagaya
Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema.
Cardiovascular research 2007;76(1):110-8.
2007: Takumi Sakamoto; Kenji Mori; Keiko Nakahara; Mikiya Miyazato; Kenji Kangawa; Hiroshi Sameshima; Noboru Murakami
Neuromedin S exerts an antidiuretic action in rats.
Biochemical and biophysical research communications 2007;361(2):457-61.
2007: Masayasu Kojima; Kenji Kangawa
[Structure and function of ghrelin].
Seikagaku. The Journal of Japanese Biochemical Society 2007;79(9):853-67.
2007: Mamoru Arakawa; Hidekazu Suzuki; Yuriko Minegishi; Yasushi Fukushima; Tatsuhiro Masaoka; Takashi Ishikawa; Hiroshi Hosoda; Kenji Kangawa; Toshifumi Hibi
Enhanced ghrelin expression and subsequent acid secretion in mice with genetic H(2)-receptor knockout.
Journal of gastroenterology 2007;42(9):711-8.
2007: Hideyuki Takahashi; Yohei Kurose; Muneyuki Sakaida; Yoshihiro Suzuki; Shigeki Kobayashi; Toshihisa Sugino; Masayasu Kojima; Kenji Kangawa; Yoshihisa Hasegawa; Yoshiaki Terashima
Ghrelin differentially modulates glucose-induced insulin secretion according to feeding status in sheep.
The Journal of endocrinology 2007;194(3):621-5.
2007: Hiroshi Iwakura; Takashi Akamizu; Hiroyuki Ariyasu; Taiga Irako; Kiminori Hosoda; Kazuwa Nakao; Kenji Kangawa
Effects of ghrelin administration on decreased growth hormone status in obese animals.
American journal of physiology. Endocrinology and metabolism 2007;293(3):E819-25.
2007: Mari Murashita; Ichiro Kusumi; Hiroshi Hosoda; Kenji Kangawa; Tsukasa Koyama
Acute administration of clozapine concurrently increases blood glucose and circulating plasma ghrelin levels in rats.
Psychoneuroendocrinology 2007;32(7):777-84.
2007: Takefumi Itoh; Hiroaki Obata; Shinsuke Murakami; Kaoru Hamada; Kenji Kangawa; Hiroshi Kimura; Noritoshi Nagaya
Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats.
American journal of physiology. Lung cellular and molecular physiology 2007;293(2):L446-52.
2007: Fumiki Yoshihara; Andrea Ernst; Nils G. Morgenthaler; Takeshi Horio; Satoko Nakamura; Hajime Nakahama; Hiroto Nakata; Andreas Bergmann; Kenji Kangawa; Yuhei Kawano
Midregional proadrenomedullin reflects cardiac dysfunction in haemodialysis patients with cardiovascular disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22(8):2263-8.
2007: Miho Sato; Keiko Nakahara; Mikiya Miyazato; Kenji Kangawa; Noboru Murakami
Regulation of GH secretagogue receptor gene expression in the rat nodose ganglion.
The Journal of endocrinology 2007;194(1):41-6.
2007: Takakazu Kawamata; Akio Inui; Hiroshi Hosoda; Kenji Kangawa; Tomokatsu Hori
Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH.
Clinical endocrinology 2007;67(1):140-4.
2007: Mina Ushiyama; Ryuji Ikeda; Hideki Sugawara; Morikatsu Yoshida; Kenji Mori; Kenji Kangawa; Kazuhiko Inoue; Katsushi Yamada; Atsuro Miyata
Differential intracellular signaling through PAC1 isoforms as a result of alternative splicing in the first extracellular domain and the third intracellular loop.
Molecular pharmacology 2007;72(1):103-11.
2007: Tetsuro Katayama; Shohei Shimamoto; Hideyuki Oda; Keiko Nakahara; Kenji Kangawa; Noboru Murakami
Glucagon receptor expression and glucagon stimulation of ghrelin secretion in rat stomach.
Biochemical and biophysical research communications 2007;357(4):865-70.
2007: Ken Watanabe; Toshio Nishikimi; Motoki Takamuro; Kenji Yasuda; Yuichi Ishikawa; Saori Tanabe; Osamu Yamada; Toshikatsu Yagihara; Shinichi Suga; Kenji Kangawa; Hiroaki Matsuoka; Shigeyuki Echigo
Possible role of adrenomedullin in the regulation of Fontan circulation: mature form of plasma adrenomedullin is extracted in the lung in patients with Fontan procedure.
Regulatory peptides 2007;141(1-3):129-34.
2007: Tohru Miura; Keisuke Maruyama; Sei-Ichi Shimakura; Hiroyuki Kaiya; Minoru Uchiyama; Kenji Kangawa; Seiji Shioda; Kouhei Matsuda
Regulation of food intake in the goldfish by interaction between ghrelin and orexin.
Peptides 2007;28(6):1207-13.
2007: Yasuhiro Yamaguchi; Takashi Nagase; Tetsuji Tomita; Kyoko Nakamura; Shigetomo Fukuhara; Tomokazu Amano; Hiroshi Yamamoto; Yukie Ide; Misao Suzuki; Shinji Teramoto; Tomoichiro Asano; Kenji Kangawa; Naomi Nakagata; Yasuyoshi Ouchi; Hiroki Kurihara
Beta-defensin overexpression induces progressive muscle degeneration in mice.
American journal of physiology. Cell physiology 2007;292(6):C2141-9.
2007: Takashi Akamizu; Kenji Kangawa
Emerging results of anticatabolic therapy with ghrelin.
Current opinion in clinical nutrition and metabolic care 2007;10(3):278-83.
2007: Akatsuki Kawakoshi; Hiroyuki Kaiya; Larry G Riley; Tetsuya Hirano; E Gordon Grau; Mikiya Miyazato; Hiroshi Hosoda; Kenji Kangawa
Identification of a ghrelin-like peptide in two species of shark, Sphyrna lewini and Carcharhinus melanopterus.
General and comparative endocrinology 2007;151(3):259-68.
2007: Hiroyuki Kaiya; Ei-Suke Saito; Tetsuya Tachibana; Mitsuhiro Furuse; Kenji Kangawa
Changes in ghrelin levels of plasma and proventriculus and ghrelin mRNA of proventriculus in fasted and refed layer chicks.
Domestic animal endocrinology 2007;32(4):247-59.
2007: Shunsuke Ohnishi; Noritoshi Nagaya; Kenji Kangawa
[Ghrelin].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 4():186-90.
2007: Takeshi Tokudome; Ichiro Kishimoto; Takeshi Horio; Kenji Kangawa
[Cardioprotective effects of natriuretic peptides].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 4():165-9.
2007: Hiroaki Obata; Bobby Yanagawa; Koichi Tanaka; Shunsuke Ohnishi; Masaharu Kataoka; Yoshinori Miyahara; Hatsue Ishibashi-Ueda; Makoto Kodama; Yoshifusa Aizawa; Kenji Kangawa; Noritoshi Nagaya
CNP infusion attenuates cardiac dysfunction and inflammation in myocarditis.
Biochemical and biophysical research communications 2007;356(1):60-6.
2007: James T Pearson; Mikiyasu Shirai; Chieko Yokoyama; Hirotsugu Tsuchimochi; Daryl O Schwenke; Akito Shimouchi; Kenji Kangawa; Tadashi Tanabe
Alpha2-adrenoreceptor mediated sympathoinhibition of heart rate during acute hypoxia is diminished in conscious prostacyclin synthase deficient mice.
Pflügers Archiv : European journal of physiology 2007;454(1):29-39.
2007: Jun-Ichiro Jo; Noritoshi Nagaya; Yoshinori Miyahara; Masaharu Kataoka; Mariko Harada-Shiba; Kenji Kangawa; Yasuhiko Tabata
Transplantation of genetically engineered mesenchymal stem cells improves cardiac function in rats with myocardial infarction: benefit of a novel nonviral vector, cationized dextran.
Tissue engineering 2007;13(2):313-22.
2007: Mari Murashita; Takeshi Inoue; Ichiro Kusumi; Shin Nakagawa; Kouichi Itoh; Teruaki Tanaka; Takeshi Izumi; Hiroshi Hosoda; Kenji Kangawa; Tsukasa Koyama
Glucose and lipid metabolism of long-term risperidone monotherapy in patients with schizophrenia.
Psychiatry and clinical neurosciences 2007;61(1):54-8.
2007: Koji Toshinai; Muhtashan S Mondal; Takuya Shimbara; Hideki Yamaguchi; Yukari Date; Kenji Kangawa; Masamitsu Nakazato
Ghrelin stimulates growth hormone secretion and food intake in aged rats.
Mechanisms of ageing and development 2007;128(2):182-6.
2007: Daryl O Schwenke; James T Pearson; Keiji Umetani; Kenji Kangawa; Mikiyasu Shirai
Imaging of the pulmonary circulation in the closed-chest rat using synchrotron radiation microangiography.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;102(2):787-93.
2007: Takanori Ida; Mikiya Miyazato; Kiyokazu Naganobu; Keiko Nakahara; Miho Sato; Xing-Zi Lin; Hiroyuki Kaiya; Kentaro Doi; Soushi Noda; Ayako Kubo; Noboru Murakami; Kenji Kangawa
Purification and characterization of feline ghrelin and its possible role.
Domestic animal endocrinology 2007;32(2):93-105.
2007: Daryl O Schwenke; James T Pearson; Hirotsugu Tsuchimochi; Kenji Kangawa; Mikiyasu Shirai
Pulmonary vascular reactivity of spontaneously hypertensive rats is exacerbated in response to the central administration of exogenous nitric oxide.
Clinical and experimental pharmacology & physiology 2007;34(1-2):88-94.
2007: Shunsuke Ohnishi; Bobby Yanagawa; Koichi Tanaka; Yoshinori Miyahara; Hiroaki Obata; Masaharu Kataoka; Makoto Kodama; Hatsue Ishibashi-Ueda; Kenji Kangawa; Soichiro Kitamura; Noritoshi Nagaya
Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis.
Journal of molecular and cellular cardiology 2007;42(1):88-97.
2006: Katsuya Dezaki; Hideyuki Sone; Masaru Koizumi; Masanori Nakata; Masafumi Kakei; Hideo Nagai; Hiroshi Hosoda; Kenji Kangawa; Toshihiko Yada
Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance.
Diabetes 2006;55(12):3486-93.
2006: Minami Abe; Masataka Sata; Etsu Suzuki; Ryo Takeda; Masao Takahashi; Hiroaki Nishimatsu; Daisuke Nagata; Kenji Kangawa; Hisayuki Matsuo; Ryozo Nagai; Yasunobu Hirata
Effects of adrenomedullin on acute ischaemia-induced collateral development and mobilization of bone-marrow-derived cells.
Clinical science (London, England : 1979) 2006;111(6):381-7.
2006: Miho Sato; Keiko Nakahara; Shintaro Goto; Hiroyuki Kaiya; Mikiya Miyazato; Yukari Date; Masamitsu Nakazato; Kenji Kangawa; Noboru Murakami
Effects of ghrelin and des-acyl ghrelin on neurogenesis of the rat fetal spinal cord.
Biochemical and biophysical research communications 2006;350(3):598-603.
2006: Yoshinori Miyahara; Shunsuke Ohnishi; Hiroaki Obata; Kozo Ishino; Shunji Sano; Hidezo Mori; Kenji Kangawa; Soichiro Kitamura; Noritoshi Nagaya
Beraprost sodium enhances neovascularization in ischemic myocardium by mobilizing bone marrow cells in rats.
Biochemical and biophysical research communications 2006;349(4):1242-9.
2006: Tohru Miura; Keisuke Maruyama; Sei-Ichi Shimakura; Hiroyuki Kaiya; Minoru Uchiyama; Kenji Kangawa; Seiji Shioda; Kouhei Matsuda
Neuropeptide Y mediates ghrelin-induced feeding in the goldfish, Carassius auratus.
Neuroscience letters 2006;407(3):279-83.
2006: Tomoko Ishizuka; Sachiko Nomura; Hiroshi Hosoda; Kenji Kangawa; Takeshi Watanabe; Atsushi Yamatodani
A role of the histaminergic system for the control of feeding by orexigenic peptides.
Physiology & behavior 2006;89(3):295-300.
2006: Toshio Nishikimi; Yosuke Mori; Kimihiko Ishimura; Yayoi Ishikawa; Shogo Koshikawa; Kazumi Akimoto; Naoto Minamino; Kenji Kangawa; Hiroaki Matsuoka
Chronic effect of combined treatment with omapatrilat and adrenomedullin on the progression of heart failure in rats.
American journal of hypertension 2006;19(10):1039-48.
2006: Yukari Date; Takuya Shimbara; Shuichi Koda; Koji Toshinai; Takanori Ida; Noboru Murakami; Mikiya Miyazato; Koichi Kokame; Yuta Ishizuka; Yasushi Ishida; Haruaki Kageyama; Seiji Shioda; Kenji Kangawa; Masamitsu Nakazato
Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus.
Cell metabolism 2006;4(4):323-31.
2006: Takashi Akamizu; Kenji Kangawa
Translational research on the clinical applications of ghrelin.
Endocrine journal 2006;53(5):585-91.
2006: Yoshio Iwashima; Takeshi Horio; Yoshihiko Suzuki; Shinji Kihara; Hiromi Rakugi; Kenji Kangawa; Tohru Funahashi; Toshio Ogihara; Yuhei Kawano
Adiponectin and inflammatory markers in peripheral arterial occlusive disease.
Atherosclerosis 2006;188(2):384-90.
2006: Tetsuya Tachibana; Hiroyuki Kaiya; D Michael Denbow; Kenji Kangawa; Mitsuhiro Furuse
Central ghrelin acts as an anti-dipsogenic peptide in chicks.
Neuroscience letters 2006;405(3):241-5.
2006: Hiroyuki Kaiya; Takehiro Tsukada; Shinya Yuge; Hiroko Mondo; Kenji Kangawa; Yoshio Takei
Identification of eel ghrelin in plasma and stomach by radioimmunoassay and histochemistry.
General and comparative endocrinology 2006;148(3):375-82.
2006: Kouhei Matsuda; Tohru Miura; Hiroyuki Kaiya; Keisuke Maruyama; Sei-Ichi Shimakura; Minoru Uchiyama; Kenji Kangawa; Seiji Shioda
Regulation of food intake by acyl and des-acyl ghrelins in the goldfish.
Peptides 2006;27(9):2321-5.
2006: Hiroyuki Kaiya; Ichiro Sakata; Kazutoshi Yamamoto; Aya Koda; Takafumi Sakai; Kenji Kangawa; Sakae Kikuyama
Identification of immunoreactive plasma and stomach ghrelin, and expression of stomach ghrelin mRNA in the bullfrog, Rana catesbeiana.
General and comparative endocrinology 2006;148(2):236-44.
2006: Shunsuke Ohnishi; Noritoshi Nagaya; Kenji Kangawa
[Ghrelin].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():151-5.
2006: Mina Ushiyama; Hideki Sugawara; Kazuhiko Inoue; Kenji Kangawa; Katsushi Yamada; Atsuro Miyata
Characterization of the PAC1 variants expressed in the mouse heart.
Annals of the New York Academy of Sciences 2006;1070():586-90.
2006: Kohsho Fujikawa; Tetsuya Nagayama; Kazuhiko Inoue; Naoto Minamino; Kenji Kangawa; Masaki Niiro; Atsuro Miyata
C-type natriuretic peptide is specifically augmented by pituitary adenylate cyclase-activating polypeptide in rat astrocytes.
Annals of the New York Academy of Sciences 2006;1070():282-5.
2006: Tianbao Chen; Mei Zhou; Brian Walker; Pat Harriot; Kenji Mori; Mikiya Miyazato; Kenji Kangawa; Chris Shaw
Structural and functional analogs of the novel mammalian neuropeptide, neuromedin S (NmS), in the dermal venoms of Eurasian bombinid toads.
Biochemical and biophysical research communications 2006;345(1):377-84.
2006: Shinsuke Murakami; Hiroshi Kimura; Kenji Kangawa; Noritoshi Nagaya
Physiological significance and therapeutic potential of adrenomedullin in pulmonary hypertension.
Cardiovascular & hematological disorders drug targets 2006;6(2):125-32.
2006: Yuichiro Doki; Ko Takachi; Osamu Ishikawa; Isao Miyashiro; Yo Sasaki; Hiroaki Ohigashi; Hiromu Nakajima; Hiroshi Hosoda; Kenji Kangawa; Fujiko Sasakuma; Masaaki Motoori; Shingi Imaoka
Ghrelin reduction after esophageal substitution and its correlation to postoperative body weight loss in esophageal cancer patients.
Surgery 2006;139(6):797-805.
2006: Taiga Irako; Takashi Akamizu; Hiroshi Hosoda; Hiroshi Iwakura; Hiroyuki Ariyasu; K Tojo; N Tajima; Kenji Kangawa
Ghrelin prevents development of diabetes at adult age in streptozotocin-treated newborn rats.
Diabetologia 2006;49(6):1264-73.
2006: Kouhei Matsuda; Tohru Miura; Hiroyuki Kaiya; Keisuke Maruyama; Minoru Uchiyama; Kenji Kangawa; Seiji Shioda
Stimulatory effect of n-octanoylated ghrelin on locomotor activity in the goldfish, Carassius auratus.
Peptides 2006;27(6):1335-40.
2006: Koji Toshinai; Hideki Yamaguchi; Yuxiang Sun; Roy G Smith; Akihiro Yamanaka; Takeshi Sakurai; Yukari Date; Muhtashan S Mondal; Takuya Shimbara; Takashi Kawagoe; Noboru Murakami; Mikiya Miyazato; Kenji Kangawa; Masamitsu Nakazato
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor.
Endocrinology 2006;147(5):2306-14.
2006: Daryl O Schwenke; James T Pearson; Kenji Kangawa; Mikiyasu Shirai
Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats?
Acta physiologica (Oxford, England) 2006;186(4):309-18.
2006: H Takahashi; Yohei Kurose; Shigeki Kobayashi; Toshihisa Sugino; Masayasu Kojima; Kenji Kangawa; Yoshihisa Hasegawa; Yoshiaki Terashima
Ghrelin enhances glucose-induced insulin secretion in scheduled meal-fed sheep.
The Journal of endocrinology 2006;189(1):67-75.
2006: Yoshinori Miyahara; Noritoshi Nagaya; Masaharu Kataoka; Bobby Yanagawa; Koichi Tanaka; Hiroyuki Hao; Kozo Ishino; Hideyuki Ishida; Tatsuya Shimizu; Kenji Kangawa; Shunji Sano; Teruo Okano; Soichiro Kitamura; Hidezo Mori
Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction.
Nature medicine 2006;12(4):459-65.
2006: Keiko Nakahara; Mari Nakagawa; Yukiko Baba; Miho Sato; Koji Toshinai; Yukari Date; Masamitsu Nakazato; Masayasu Kojima; Mikiya Miyazato; Hiroyuki Kaiya; Hiroshi Hosoda; Kenji Kangawa; Noboru Murakami
Maternal ghrelin plays an important role in rat fetal development during pregnancy.
Endocrinology 2006;147(3):1333-42.
2006: Masayasu Kojima; Kenji Kangawa
Drug insight: The functions of ghrelin and its potential as a multitherapeutic hormone.
Nature clinical practice. Endocrinology & metabolism 2006;2(2):80-8.
2006: Takashi Akamizu; T Murayama; Satoshi Teramukai; K Miura; I Bando; Taiga Irako; Hiroshi Iwakura; Hiroyuki Ariyasu; Hiroshi Hosoda; Harue Tada; A Matsuyama; S Kojima; T Wada; Yoshio Wakatsuki; K Matsubayashi; T Kawakita; Akira Shimizu; Masanori Fukushima; Masayuki Yokode; Kenji Kangawa
Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure.
The Journal of endocrinology 2006;188(2):333-44.
2006: Sofie M E Geelissen; Quirine Swennen; S Van der Geyten; Eduard R Kühn; H Kaiya; Kenji Kangawa; Eddy Decuypere; Johan Buyse; Veerle M Darras
Peripheral ghrelin reduces food intake and respiratory quotient in chicken.
Domestic animal endocrinology 2006;30(2):108-16.
2006: Saad Shousha; Keiko Nakahara; Miho Sato; Kenji Mori; Mikiya Miyazato; Kenji Kangawa; Noboru Murakami
Effect of neuromedin S on feeding regulation in the Japanese quail.
Neuroscience letters 2006;391(3):87-90.
2006: Yumiko Abe; Hiromitsu Sinozaki; Takeshi Takagi; Takashi Minegishi; Koichi Kokame; Kenji Kangawa; Miki Uesaka; Kaoru Miyamoto
Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible genes in human amniotic epithelial cells.
Reproductive biology and endocrinology : RB&E 2006;4():27.
2006: Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa
Biological, physiological, and pharmacological aspects of ghrelin.
Journal of pharmacological sciences 2006;100(5):398-410.
2006: Noritoshi Nagaya; Kenji Kangawa
Therapeutic potential of ghrelin in the treatment of heart failure.
Drugs 2006;66(4):439-48.
2006: Noritoshi Nagaya; Masakazu Kojima; Kenji Kangawa
Ghrelin, a novel growth hormone-releasing peptide, in the treatment of cardiopulmonary-associated cachexia.
Internal medicine (Tokyo, Japan) 2006;45(3):127-34.
2006: Ryo Takeda; Hiroaki Nishimatsu; Etsu Suzuki; Hiroshi Satonaka; Daisuke Nagata; Shigeyoshi Oba; Masataka Sata; Masao Takahashi; Yuji Yamamoto; Yasuo Terauchi; Takashi Kadowaki; Kenji Kangawa; Tadaichi Kitamura; Ryozo Nagai; Yasunobu Hirata
Ghrelin improves renal function in mice with ischemic acute renal failure.
Journal of the American Society of Nephrology : JASN 2006;17(1):113-21.
2006: Ko Takachi; Yuichiro Doki; Osamu Ishikawa; Isao Miyashiro; Yo Sasaki; Hiroaki Ohigashi; Kohei Murata; Hiromu Nakajima; Hiroshi Hosoda; Kenji Kangawa; Fujiko Sasakuma; Shingi Imaoka
Postoperative ghrelin levels and delayed recovery from body weight loss after distal or total gastrectomy.
The Journal of surgical research 2006;130(1):1-7.
2006: Shinsuke Murakami; Noritoshi Nagaya; Takefumi Itoh; Masaharu Kataoka; Takashi Iwase; Takeshi Horio; Yoshinori Miyahara; Yoshiki Sakai; Kenji Kangawa; Hiroshi Kimura
Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice.
American journal of physiology. Lung cellular and molecular physiology 2006;290(1):L59-65.
2005: Masaharu Kataoka; Noritoshi Nagaya; Toru Satoh; Takefumi Itoh; Shinsuke Murakami; Takashi Iwase; Yoshinori Miyahara; Shingo Kyotani; Yoshiki Sakai; Kenji Kangawa; Satoshi Ogawa
A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension.
American journal of respiratory and critical care medicine 2005;172(12):1575-80.
2005: Tomohiro Makino; Masaru Matsumoto; Yuji Suzuki; Yasuo Kitajima; Katsuhiko Yamamoto; Masashi Kuramoto; Yoshiharu Minamitake; Kenji Kangawa; Masayuki Yabuta
Semisynthesis of human ghrelin: condensation of a Boc-protected recombinant peptide with a synthetic O-acylated fragment.
Biopolymers 2005;79(5):238-47.
2005: T Uehara; Ichiro M Omori; K Nakamura; M Suda; Y Hosoda; T Minegishi; Masahiko Mikuni; Kenji Kangawa
Plasma des-acyl and acyl ghrelin in patients with eating disorders.
Eating and weight disorders : EWD 2005;10(4):264-6.
2005: Yukio Hayashi; Hiroshi Ueyama; Takashi Mashimo; Kenji Kangawa; Naoto Minamino
Circulating mature adrenomedullin is related to blood volume in full-term pregnancy.
Anesthesia and analgesia 2005;101(6):1816-20.
2005: Kimihiko Ishimura; Toshio Nishikimi; Kazumi Akimoto; Hidehiko Ono; Kenji Kangawa; Hiroaki Matsuoka
Renoprotective effect of long-term combined treatment with adrenomedullin and omapatrilat in hypertensive rats.
Journal of hypertension 2005;23(12):2287-96.
2005: Masayuki Yokoyama; Noboru Murakami; Kiyokazu Naganobu; Hiroshi Hosoda; Kenji Kangawa; Keiko Nakahara
Relationship between growth and plasma concentrations of ghrelin and growth hormone in juvenile beagle dogs.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2005;67(11):1189-92.
2005: Masafumi Kamiyama; Noriaki Usui; Shinkichi Kamata; Masahiro Fukuzawa; Noritoshi Nagaya; Kenji Kangawa
Adrenomedullin is up-regulated in nitrofen-induced fetal pulmonary hypoplasia.
Journal of pediatric surgery 2005;40(10):1562-7.
2005: Takanori Ida; Kenji Mori; Mikiya Miyazato; Yutaka Egi; Shinsuke Abe; Keiko Nakahara; Masugi Nishihara; Kenji Kangawa; Noboru Murakami
Neuromedin s is a novel anorexigenic hormone.
Endocrinology 2005;146(10):4217-23.
2005: Hiroyuki Kaiya; Brian C Small; A Lelania Bilodeau; Brian S Shepherd; Masayasu Kojima; Hiroshi Hosoda; Kenji Kangawa
Purification, cDNA cloning, and characterization of ghrelin in channel catfish, Ictalurus punctatus.
General and comparative endocrinology 2005;143(3):201-10.
2005: Noritoshi Nagaya; Takefumi Itoh; Shinsuke Murakami; Hideo Oya; Masaaki Uematsu; Kunio Miyatake; Kenji Kangawa
Treatment of cachexia with ghrelin in patients with COPD.
Chest 2005;128(3):1187-93.
2005: Fumiki Yoshihara; Takeshi Horio; Satoko Nakamura; Masayoshi Yoshii; Chinami Ogata; Hajime Nakahama; Takashi Inenaga; Kenji Kangawa; Yuhei Kawano
Adrenomedullin reflects cardiac dysfunction, excessive blood volume, and inflammation in hemodialysis patients.
Kidney international 2005;68(3):1355-63.
2005: Shinsuke Murakami; Noritoshi Nagaya; Takefumi Itoh; Takashi Iwase; Toshiya Fujisato; Keisuke Nishioka; Kaoru Hamada; Kenji Kangawa; Hiroshi Kimura
Adrenomedullin regenerates alveoli and vasculature in elastase-induced pulmonary emphysema in mice.
American journal of respiratory and critical care medicine 2005;172(5):581-9.
2005: Noritoshi Nagaya; Kenji Kangawa; Takefumi Itoh; Takashi Iwase; Shinsuke Murakami; Yoshinori Miyahara; Takafumi Fujii; Masaaki Uematsu; Hajime Ohgushi; Masakazu Yamagishi; Takeshi Tokudome; Hidezo Mori; Kunio Miyatake; Soichiro Kitamura
Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy.
Circulation 2005;112(8):1128-35.
2005: Hiroshi Hosoda; Kenji Kangawa
[Ghrelin measurement].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 8():484-7.
2005: Yukari Date; Koji Toshinai; Shuichi Koda; Mikiya Miyazato; Takuya Shimbara; Tomoko Tsuruta; Akira Niijima; Kenji Kangawa; Masamitsu Nakazato
Peripheral interaction of ghrelin with cholecystokinin on feeding regulation.
Endocrinology 2005;146(8):3518-25.
2005: Yuka Abiko; Hidekazu Suzuki; Tatsuhiro Masaoka; Sachiko Nomura; Kumiko Kurabayashi; Hiroshi Hosoda; Kenji Kangawa; Toshifumi Hibi
Enhanced plasma ghrelin levels in Helicobacter pylori-colonized, interleukin-1-receptor type 1-homozygous knockout (IL-1R1-/-) mice.
World journal of gastroenterology : WJG 2005;11(27):4148-53.
2005: Maiko Moriyama; Takahiro Sato; Hiromasa Inoue; Satoru Fukuyama; Hitoshi Teranishi; Kenji Kangawa; Tatsuhiko Kano; Akihiko Yoshimura; Masayasu Kojima
The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells.
The Journal of experimental medicine 2005;202(2):217-24.
2005: Takanori Yasu; Toshio Nishikimi; Nobuhiko Kobayashi; Nahoko Ikeda; Hiroto Ueba; Tomohiro Nakamura; Hiroshi Funayama; Norifumi Kubo; Masanobu Kawakami; Hiroaki Matsuoka; Kenji Kangawa; Muneyasu Saito
Up-regulated synthesis of mature-type adrenomedullin in coronary circulation immediately after reperfusion in patients with anterior acute myocardial infarction.
Regulatory peptides 2005;129(1-3):161-6.
2005: Seiichiro Fukuhara; Hidekazu Suzuki; Tatsuhiro Masaoka; Mamoru Arakawa; Hiroshi Hosoda; Yuriko Minegishi; Kenji Kangawa; Hiromasa Ishii; Masaki Kitajima; Toshifumi Hibi
Enhanced ghrelin secretion in rats with cysteamine-induced duodenal ulcers.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(1):G138-45.
2005: Takeshi Tokudome; Takeshi Horio; Ichiro Kishimoto; Takeshi Soeki; Kenji Mori; Yuhei Kawano; Masakazu Kohno; David L Garbers; Kazuwa Nakao; Kenji Kangawa
Calcineurin-nuclear factor of activated T cells pathway-dependent cardiac remodeling in mice deficient in guanylyl cyclase A, a receptor for atrial and brain natriuretic peptides.
Circulation 2005;111(23):3095-104.
2005: Toshiaki Shinomiya; Mikihiko Fukunaga; Takashi Akamizu; Taiga Irako; Masayuki Yokode; Kenji Kangawa; Yoshihide Nakai; Yoshikatsu Nakai
Plasma acylated ghrelin levels correlate with subjective symptoms of functional dyspepsia in female patients.
Scandinavian journal of gastroenterology 2005;40(6):648-53.
2005: Yohei Kurose; Javed Iqbal; Alexandra Rao; Y Murata; Yoshihisa Hasegawa; Yoshiaki Terashima; Masayasu Kojima; Kenji Kangawa; Iain J Clarke
Changes in expression of the genes for the leptin receptor and the growth hormone-releasing peptide/ghrelin receptor in the hypothalamic arcuate nucleus with long-term manipulation of adiposity by dietary means.
Journal of neuroendocrinology 2005;17(6):331-40.
2005: Takashi Iwase; Noritoshi Nagaya; Takafumi Fujii; Takefumi Itoh; Shinsuke Murakami; Toshio Matsumoto; Kenji Kangawa; Soichiro Kitamura
Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia.
Cardiovascular research 2005;66(3):543-51.
2005: Noritoshi Nagaya; Hidezo Mori; Shinsuke Murakami; Kenji Kangawa; Soichiro Kitamura
Adrenomedullin: angiogenesis and gene therapy.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(6):R1432-7.
2005: Yoshihiro Nishi; Hiroshi Hiejima; Hiroharu Mifune; Takahiro Sato; Kenji Kangawa; Masayasu Kojima
Developmental changes in the pattern of ghrelin's acyl modification and the levels of acyl-modified ghrelins in murine stomach.
Endocrinology 2005;146(6):2709-15.
2005: Fumiki Yoshihara; Shin-ichi Suga; Naomi Yasui; Takeshi Horio; Takeshi Tokudome; Toshio Nishikimi; Yuhei Kawano; Kenji Kangawa
Chronic administration of adrenomedullin attenuates the hypertension and increases renal nitric oxide synthase in Dahl salt-sensitive rats.
Regulatory peptides 2005;128(1):7-13.
2005: Nobuhiro Fukushima; Reiko Hanada; Hitoshi Teranishi; Yoshihiko Fukue; Toshiaki Tachibana; Hiroshi Ishikawa; Shu Takeda; Yasuhiro Takeuchi; Seiji Fukumoto; Kenji Kangawa; Kensei Nagata; Masayasu Kojima
Ghrelin directly regulates bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(5):790-8.
2005: Yoshihiro Nishi; Hiroshi Hiejima; Hiroshi Hosoda; Hiroyuki Kaiya; Kenji Mori; Yoshihiko Fukue; Toshihiko Yanase; Hajime Nawata; Kenji Kangawa; Masayasu Kojima
Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin.
Endocrinology 2005;146(5):2255-64.
2005: Hiroshi Iwakura; Kiminori Hosoda; Choel Son; Junji Fujikura; Tsutomu Tomita; Michio Noguchi; Hiroyuki Ariyasu; Kazuhiko Takaya; Hiroaki Masuzaki; Yoshihiro Ogawa; Tatsuya Hayashi; Gen Inoue; Takashi Akamizu; Hiroshi Hosoda; Masayasu Kojima; Hiroshi Itoh; Shinya Toyokuni; Kenji Kangawa; Kazuwa Nakao
Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice.
The Journal of biological chemistry 2005;280(15):15247-56.
2005: Fumiki Yoshihara; Toshio Nishikimi; Ichiro Okano; Jun Hino; Takeshi Horio; Takeshi Tokudome; Shin-ichi Suga; Hiroaki Matsuoka; Kenji Kangawa; Yuhei Kawano
Upregulation of intracardiac adrenomedullin and its receptor system in rats with volume overload-induced cardiac hypertrophy.
Regulatory peptides 2005;127(1-3):239-44.
2005: Yi Shi; Fumiki Yoshihara; Hajime Nakahama; Naotsugu Ichimaru; Koji Yazawa; Masaharu Sada; Rieko Goto; Yuhei Kawano; Toshiki Moriyama; Shiro Takahara; Akihiko Okuyama; Kenji Kangawa
A novel immunosuppressant FTY720 ameliorates proteinuria and alterations of intrarenal adrenomedullin in rats with autoimmune glomerulonephritis.
Regulatory peptides 2005;127(1-3):233-8.
2005: Ichiro Yokota; Seiko Kitamura; Hiroshi Hosoda; Yumiko Kotani; Kenji Kangawa
Concentration of the n-octanoylated active form of ghrelin in fetal and neonatal circulation.
Endocrine journal 2005;52(2):271-6.
2005: Masayasu Kojima; Kenji Kangawa
Ghrelin: structure and function.
Physiological reviews 2005;85(2):495-522.
2005: Toshio Nishikimi; Kazuyoshi Tadokoro; Kazumi Akimoto; Yosuke Mori; Yayoi Ishikawa; Kimihiko Ishimura; Takeshi Horio; Kenji Kangawa; Hiroaki Matsuoka
Response of adrenomedullin system to cytokine in cardiac fibroblasts-role of adrenomedullin as an antifibrotic factor.
Cardiovascular research 2005;66(1):104-13.
2005: Saad Shousha; Keiko Nakahara; Masayasu Kojima; Mikiya Miyazato; Hiroshi Hosoda; Kenji Kangawa; Noboru Murakami
Different effects of peripheral and central ghrelin on regulation of food intake in the Japanese quail.
General and comparative endocrinology 2005;141(2):178-83.
2005: Kenichiro Hanabusa; Noritoshi Nagaya; Takashi Iwase; Takefumi Itoh; Shinsuke Murakami; Yoshito Shimizu; Waro Taki; Kunio Miyatake; Kenji Kangawa
Adrenomedullin enhances therapeutic potency of mesenchymal stem cells after experimental stroke in rats.
Stroke; a journal of cerebral circulation 2005;36(4):853-8.
2005: Haruaki Kageyama; Hisayuki Funahashi; Masami Hirayama; Fumiko Takenoya; Tetsuro Kita; Sachi Kato; Junko Sakurai; Eun Young Lee; Shuji Inoue; Yukari Date; Masamitsu Nakazato; Kenji Kangawa; Seiji Shioda
Morphological analysis of ghrelin and its receptor distribution in the rat pancreas.
Regulatory peptides 2005;126(1-2):67-71.
2005: Tsutomu Hashizume; Mami Horiuchi; Sumie Nonaka; Etsuko Kasuya; Masayasu Kojima; Hiroshi Hosoda; Kenji Kangawa
Effects of ghrelin on growth hormone secretion in vivo in ruminants.
Regulatory peptides 2005;126(1-2):61-5.
2005: Muhtashan S Mondal; Yukari Date; Hideki Yamaguchi; Koji Toshinai; Tomoko Tsuruta; Kenji Kangawa; Masamitsu Nakazato
Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus.
Regulatory peptides 2005;126(1-2):55-9.
2005: Hiroaki Ueno; Hideki Yamaguchi; Kenji Kangawa; Masamitsu Nakazato
Ghrelin: a gastric peptide that regulates food intake and energy homeostasis.
Regulatory peptides 2005;126(1-2):11-9.
2005: Takafumi Fujii; Noritoshi Nagaya; Takashi Iwase; Shinsuke Murakami; Yoshinori Miyahara; Kazuhiro Nishigami; Hatsue Ishibashi-Ueda; Mikiyasu Shirai; Takefumi Itoh; Kozo Ishino; Shunji Sano; Kenji Kangawa; Hidezo Mori
Adrenomedullin enhances therapeutic potency of bone marrow transplantation for myocardial infarction in rats.
American journal of physiology. Heart and circulatory physiology 2005;288(3):H1444-50.
2005: Takeshi Soeki; Ichiro Kishimoto; Hiroyuki Okumura; Takeshi Tokudome; Takeshi Horio; Kenji Mori; Kenji Kangawa
C-type natriuretic peptide, a novel antifibrotic and antihypertrophic agent, prevents cardiac remodeling after myocardial infarction.
Journal of the American College of Cardiology 2005;45(4):608-16.
2005: Ei-Suke Saito; Hiroyuki Kaiya; Tetsuya Tachibana; Shozo Tomonaga; D Michael Denbow; Kenji Kangawa; Mitsuhiro Furuse
Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks.
Regulatory peptides 2005;125(1-3):201-8.
2005: Kikuko Iwanaga; Noboru Takamura; Yasuyo Abe; Ye Zhaojia; Ken Shinzato; Hiroshi Hosoda; Kenji Kangawa; Akira Ohtsuru; Shigeru Kohno; Shunichi Yamashita; Kiyoshi Aoyagi
Plasma concentrations of adrenomedullin and ghrelin in hemodialysis patients with sustained and episodic hypotension.
Endocrine journal 2005;52(1):23-8.
2005: Saad Shousha; Keiko Nakahara; Mikiya Miyazato; Kenji Kangawa; Noboru Murakami
Endogenous neuromedin U has anorectic effects in the Japanese quail.
General and comparative endocrinology 2005;140(3):156-63.
2005: Kenji Mori; Mikiya Miyazato; Takanori Ida; Noboru Murakami; Ryota Serino; Yoichi Ueta; Masayasu Kojima; Kenji Kangawa
Identification of neuromedin S and its possible role in the mammalian circadian oscillator system.
The EMBO journal 2005;24(2):325-35.
2005: Takashi Iwase; Noritoshi Nagaya; Takafumi Fujii; Takefumi Itoh; Hatsue Ishibashi-Ueda; Masakazu Yamagishi; Kunio Miyatake; Toshio Matsumoto; Soichiro Kitamura; Kenji Kangawa
Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia.
Circulation 2005;111(3):356-62.
2005: Toshio Nishikimi; Xin Wang; Kazumi Akimoto; Kazuyoshi Tadokoro; Yosuke Mori; Yayoi Ishikawa; Kimihiko Ishimura; Fumiki Yoshihara; Naoto Minamino; Kenji Kangawa; Hiroaki Matsuoka
Alteration of renal adrenomedullin and its receptor system in the severely hypertensive rat: effect of diuretic.
Regulatory peptides 2005;124(1-3):89-98.
2005: Takeshi Horio; Toshiyuki Maki; Ichiro Kishimoto; Takeshi Tokudome; Hiroyuki Okumura; Fumiki Yoshihara; Shin-ichi Suga; Satoshi Takeo; Yuhei Kawano; Kenji Kangawa
Production and autocrine/paracrine effects of endogenous insulin-like growth factor-1 in rat cardiac fibroblasts.
Regulatory peptides 2005;124(1-3):65-72.
2005: Hisafumi Matsuoka; Hiroshi Hosoda; Hisae Sugawara; Saika Iwama; Hye Sook Kim; Kenji Kangawa; Shigetaka Sugihara
Short-term secretory regulation of ghrelin during growth hormone provocative tests in prepubertal children with various growth hormone secretory capacities.
Hormone research 2005;64(6):274-9.
2005: Tatsuhiro Masaoka; Hidekazu Suzuki; Hiroyuki Imaeda; Hiroshi Hosoda; Tadashi Ohara; Tetsuo Morishita; Hiromasa Ishii; Kenji Kangawa; Toshifumi Hibi
Long-term strict monitoring of plasma ghrelin and other serological markers of gastric diseases after Helicobacter pylori eradication.
Hepato-gastroenterology 2005;52(61):1-4.
2005: Masayuki Yokoyama; Keiko Nakahara; Masayasu Kojima; Hiroshi Hosoda; Kenji Kangawa; Noboru Murakami
Influencing the between-feeding and endocrine responses of plasma ghrelin in healthy dogs.
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(1):155-60.
2005: Shigetomo Fukuhara; Atsuko Sakurai; Hideto Sano; Akiko Yamagishi; Satoshi Somekawa; Nobuyuki Takakura; Yoshihiko Saito; Kenji Kangawa; Naoki Mochizuki
Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway.
Molecular and cellular biology 2005;25(1):136-46.
2005: Takashi Akamizu; Toshiaki Shinomiya; Taiga Irako; Mikihiko Fukunaga; Yoshihide Nakai; Yoshikatsu Nakai; Kenji Kangawa
Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay.
The Journal of clinical endocrinology and metabolism 2005;90(1):6-9.
2005: Hiroyuki Ariyasu; Kazuhiko Takaya; Hiroshi Iwakura; Hiroshi Hosoda; Takashi Akamizu; Yuji Arai; Kenji Kangawa; Kazuwa Nakao
Transgenic mice overexpressing des-acyl ghrelin show small phenotype.
Endocrinology 2005;146(1):355-64.
2005: Mari Murashita; Ichiro Kusumi; Takeshi Inoue; Yoshito Takahashi; Hiroshi Hosoda; Kenji Kangawa; Tsukasa Koyama
Olanzapine increases plasma ghrelin level in patients with schizophrenia.
Psychoneuroendocrinology 2005;30(1):106-10.
2004: Noritoshi Nagaya; Junji Moriya; Yoshio Yasumura; Masaaki Uematsu; Fumiaki Ono; Wataru Shimizu; Kazuyuki Ueno; Masafumi Kitakaze; Kunio Miyatake; Kenji Kangawa
Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure.
Circulation 2004;110(24):3674-9.
2004: Tetsuya Mizutani; Miki Yoshino; Tomoko Satake; Miyuki Nakagawa; Ryuta Ishimura; Chiharu Tohyama; Koichi Kokame; Kenji Kangawa; Kaoru Miyamoto
Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible and -suppressive genes in the rat placenta: induction of interferon-regulated genes with possible inhibitory roles for angiogenesis in the placenta.
Endocrine journal 2004;51(6):569-77.
2004: Katsuya Dezaki; Hiroshi Hosoda; Masafumi Kakei; Suzuko Hashiguchi; Masatomo Watanabe; Kenji Kangawa; Toshihiko Yada
Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents.
Diabetes 2004;53(12):3142-51.
2004: Masayasu Kojima; Hiroshi Hosoda; Kenji Kangawa
Clinical endocrinology and metabolism. Ghrelin, a novel growth-hormone-releasing and appetite-stimulating peptide from stomach.
Best practice & research. Clinical endocrinology & metabolism 2004;18(4):517-30.
2004: Takefumi Itoh; Noritoshi Nagaya; Shinsuke Murakami; Takafumi Fujii; Takashi Iwase; Hatsue Ishibashi-Ueda; Chikao Yutani; Masakazu Yamagishi; Hiroshi Kimura; Kenji Kangawa
C-type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats.
American journal of respiratory and critical care medicine 2004;170(11):1204-11.
2004: Shinsuke Murakami; Noritoshi Nagaya; Takefumi Itoh; Takafumi Fujii; Takashi Iwase; Kaoru Hamada; Hiroshi Kimura; Kenji Kangawa
C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice.
American journal of physiology. Lung cellular and molecular physiology 2004;287(6):L1172-7.
2004: Noritoshi Nagaya; Takafumi Fujii; Takashi Iwase; Hajime Ohgushi; Takefumi Itoh; Masaaki Uematsu; Masakazu Yamagishi; Hidezo Mori; Kenji Kangawa; Soichiro Kitamura
Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis.
American journal of physiology. Heart and circulatory physiology 2004;287(6):H2670-6.
2004: Noritoshi Nagaya; Kenji Kangawa
Adrenomedullin in the treatment of pulmonary hypertension.
Peptides 2004;25(11):2013-8.
2004: Keiko Nakahara; Masayasu Kojima; Reiko Hanada; Yutaka Egi; Takanori Ida; Mikiya Miyazato; Kenji Kangawa; Noboru Murakami
Neuromedin U is involved in nociceptive reflexes and adaptation to environmental stimuli in mice.
Biochemical and biophysical research communications 2004;323(2):615-20.
2004: Takefumi Itoh; Noritoshi Nagaya; Masanori Yoshikawa; Atsuhiko Fukuoka; Hideaki Takenaka; Yoshito Shimizu; Yoshinori Haruta; Hideo Oya; Masakazu Yamagishi; Hiroshi Hosoda; Kenji Kangawa; Hiroshi Kimura
Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2004;170(8):879-82.
2004: Mami Yamazaki; H Kobayashi; Toru Tanaka; Kenji Kangawa; Kinji Inoue; Takafumi Sakai
Ghrelin-induced growth hormone release from isolated rat anterior pituitary cells depends on intracellullar and extracellular Ca2+ sources.
Journal of neuroendocrinology 2004;16(10):825-31.
2004: Ryoko Takeno; Yasuhiko Okimura; Genzo Iguchi; Masahiko Kishimoto; Takumi Kudo; Kentaro Takahashi; Yutaka Takahashi; Hiroshi Kaji; Masakazu Ohno; Hajime Ikuta; Yoshikazu Kuroda; Tetsuji Obara; Hiroshi Hosoda; Kenji Kangawa; Kazuo Chihara
Intravenous administration of ghrelin stimulates growth hormone secretion in vagotomized patients as well as normal subjects.
European journal of endocrinology / European Federation of Endocrine Societies 2004;151(4):447-50.
2004: Reiko Hanada; Hitoshi Teranishi; James Todd Pearson; Mamoru Kurokawa; Hiroshi Hosoda; Nobuhiro Fukushima; Yoshihiko Fukue; Ryota Serino; Hiroaki Fujihara; Yoichi Ueta; Masahito Ikawa; Masaru Okabe; Noboru Murakami; Mikiyasu Shirai; Hironobu Yoshimatsu; Kenji Kangawa; Masayasu Kojima
Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway.
Nature medicine 2004;10(10):1067-73.
2004: Noritoshi Nagaya; Kenji Kangawa
[Ghrelin in the treatment of cardiovascular disease].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():430-4.
2004: Takashi Akamizu; Taiga Irako; Hiroshi Hosoda; Kazuhiko Takaya; Kenji Kangawa
[Translational research of ghrelin in endocrine and metabolic diseases].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():424-9.
2004: Hiroshi Hosoda; Kenji Kangawa
[Role of ghrelin in cancer].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():421-3.
2004: Kazuhiko Takaya; Kazuwa Nakao; Kenji Kangawa
[Roles of ghrelin in growth and aging].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():414-6.
2004: Hiroyuki Ariyasu; Kazuwa Nakao; Kenji Kangawa
[Role of ghrelin in anorexia nervosa].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():410-3.
2004: Noboru Murakami; Keiko Nakahara; Kenji Kangawa
[Role of ghrelin in fetuses and neonates].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():392-5.
2004: Kazuhiko Takaya; Kazuwa Nakao; Kenji Kangawa
[Effects of ghrelin in aged subjects].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():377-9.
2004: Kazuhiko Takaya; Kazuwa Nakao; Kenji Kangawa
[Neuroendocrine effects of ghrelin].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():369-72.
2004: Hiroshi Hosoda; Kenji Kangawa
[Ghrelin measurement].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():354-6.
2004: Hiroshi Hosoda; Kenji Kangawa
[Distribution of ghrelin producing-cells and regulation of their biosynthesis].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():336-9.
2004: Masayasu Kojima; Kenji Kangawa
[Structure of ghrelin].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():324-7.
2004: Kenji Kangawa; Masayasu Kojima; Hiroshi Hosoda
[Discovery of ghrelin and its physiological significance].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():317-23.
2004: Yukari Okano; Kenji Kangawa
[Role of adrenomedullin in septic shock].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():276-9.
2004: Noritoshi Nagaya; Kenji Kangawa
[Adrenomedullin in pulmonary hypertension].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():264-8.
2004: Kenji Kangawa; Naoto Minamino; Hisayuki Matsuo
[Structure and function of the natriuretic peptide family].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():10-7.
2004: Hidekazu Suzuki; Tatsuhiro Masaoka; Hiroshi Hosoda; Sachiko Nomura; Tadashi Ohara; Kenji Kangawa; Hiromasa Ishii; Toshifumi Hibi
Plasma ghrelin concentration correlates with the levels of serum pepsinogen I and pepsinogen I/II ratio--a possible novel and non-invasive marker for gastric atrophy.
Hepato-gastroenterology 2004;51(59):1249-54.
2004: Yoichi Takami; Takeshi Horio; Yoshio Iwashima; Shin Takiuchi; Kei Kamide; Fumiki Yoshihara; Satoko Nakamura; Hajime Nakahama; Takashi Inenaga; Kenji Kangawa; Yuhei Kawano
Diagnostic and prognostic value of plasma brain natriuretic peptide in non-dialysis-dependent CRF.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2004;44(3):420-8.
2004: M Kamei; Y Hayashi; Katsuro Kikumoto; Y Kawai; Kenji Kangawa; Masakazu Kuro; N Minaminoals
Effect of cardiopulmonary bypass on pulmonary clearance of adrenomedullin in humans.
Acta anaesthesiologica Scandinavica 2004;48(8):980-5.
2004: Kazuo Komamura; Rie Tatsumi; Jun-ichi Miyazaki; Kunio Matsumoto; Eiji Yamato; Toshikazu Nakamura; Yoshito Shimizu; Takeshi Nakatani; Soichiro Kitamura; Hitonobu Tomoike; Masafumi Kitakaze; Kenji Kangawa; Kunio Miyatake
Treatment of dilated cardiomyopathy with electroporation of hepatocyte growth factor gene into skeletal muscle.
Hypertension 2004;44(3):365-71.
2004: Naotetsu Kanamoto; Takashi Akamizu; Tetsuya Tagami; Yuji Hataya; Kenji Moriyama; Kazuhiko Takaya; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa; Kazuwa Nakao
Genomic structure and characterization of the 5'-flanking region of the human ghrelin gene.
Endocrinology 2004;145(9):4144-53.
2004: Yoshihiko Suzuki; Takeshi Horio; Hiroshi Nonogi; Tokio Hayashi; Kazuo Kitamura; Tanenao Eto; Kenji Kangawa; Yuhei Kawano
Adrenomedullin as a sensitive marker for coronary and peripheral arterial complications in patients with atherosclerotic risks.
Peptides 2004;25(8):1321-6.
2004: Toshio Nishikimi; Hiroshi Asakawa; Hiroshi Iida; Yasushi Matsushita; Ikuko Shibasaki; Kazuyoshi Tadokoro; Yosuke Mori; Hideaki Mori; Yoshihiko Mochizuki; Yoshitaka Okamura; Shinichiro Miyoshi; Kenji Kangawa; Hiroaki Matsuoka
Different secretion patterns of two molecular forms of cardiac adrenomedullin in pressure- and volume-overloaded human heart failure.
Journal of cardiac failure 2004;10(4):321-7.
2004: Hiroyuki Kaiya; Ichiro Sakata; Masayasu Kojima; Hiroshi Hosoda; Takafumi Sakai; Kenji Kangawa
Structural determination and histochemical localization of ghrelin in the red-eared slider turtle, Trachemys scripta elegans.
General and comparative endocrinology 2004;138(1):50-7.
2004: Ryosai Nakamura; Johji Kato; Kazuo Kitamura; Hisamitsu Onitsuka; Takuroh Imamura; Yuanning Cao; Kousuke Marutsuka; Yujiro Asada; Kenji Kangawa; Tanenao Eto
Adrenomedullin administration immediately after myocardial infarction ameliorates progression of heart failure in rats.
Circulation 2004;110(4):426-31.
2004: Ichiro Sakata; Tsukasa Mori; Hiroyuki Kaiya; Mami Yamazaki; Kenji Kangawa; Kinji Inoue; Takafumi Sakai
Localization of ghrelin-producing cells in the stomach of the rainbow trout (Oncorhynchus mykiss).
Zoological science 2004;21(7):757-62.
2004: Toshihisa Sugino; Yoshihisa Hasegawa; Yohei Kurose; Masayasu Kojima; Kenji Kangawa; Yoshiaki Terashima
Effects of ghrelin on food intake and neuroendocrine function in sheep.
Animal reproduction science 2004;82-83():183-94.
2004: James T Pearson; Mikiyasu Shirai; Haruo Ito; Noriyuki Tokunaga; Hirotsugu Tsuchimochi; Naoki Nishiura; Daryl O Schwenke; Hatsue Ishibashi-Ueda; Ryuichi Akiyama; Hidezo Mori; Kenji Kangawa; Hiroyuki Suga; Naoto Yagi
In situ measurements of crossbridge dynamics and lattice spacing in rat hearts by x-ray diffraction: sensitivity to regional ischemia.
Circulation 2004;109(24):2976-9.
2004: Yoshikatsu Nakai; Hiroshi Hosoda; Kazuko Nin; Chizuru Ooya; Hiromi Hayashi; Takashi Akamizu; Kenji Kangawa
Short-term secretory regulation of the active form of ghrelin and total ghrelin during an oral glucose tolerance test in patients with anorexia nervosa.
European journal of endocrinology / European Federation of Endocrine Societies 2004;150(6):913-4.
2004: Takeshi Tokudome; Takeshi Horio; Fumiki Yoshihara; Shin-ichi Suga; Yuhei Kawano; Masakazu Kohno; Kenji Kangawa
Direct effects of high glucose and insulin on protein synthesis in cultured cardiac myocytes and DNA and collagen synthesis in cardiac fibroblasts.
Metabolism: clinical and experimental 2004;53(6):710-5.
2004: Hiroshi Hosoda; Kentaro Doi; Noritoshi Nagaya; Hiroyuki Okumura; Eiichiro Nakagawa; Mitsunobu Enomoto; Fumiaki Ono; Kenji Kangawa
Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples.
Clinical chemistry 2004;50(6):1077-80.
2004: Keiko Nakahara; Reiko Hanada; Noboru Murakami; Hitoshi Teranishi; Hideko Ohgusu; Nobuhiro Fukushima; Maiko Moriyama; Takanori Ida; Kenji Kangawa; Masayasu Kojima
The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system.
Biochemical and biophysical research communications 2004;318(1):156-61.
2004: Jun Hino; Kenji Kangawa; Hisayuki Matsuo; Tsutomu Nohno; Shin-ichiro NISHIMATSU
Bone morphogenetic protein-3 family members and their biological functions.
Frontiers in bioscience : a journal and virtual library 2004;9():1520-9.
2004: Takeshi Tokudome; Takeshi Horio; Takeshi Soeki; Kenji Mori; Ichiro Kishimoto; Shin-ichi Suga; Fumiki Yoshihara; Yuhei Kawano; Masakazu Kohno; Kenji Kangawa
Inhibitory effect of C-type natriuretic peptide (CNP) on cultured cardiac myocyte hypertrophy: interference between CNP and endothelin-1 signaling pathways.
Endocrinology 2004;145(5):2131-40.
2004: Takeshi Tokudome; Takeshi Horio; Megumu Fukunaga; Hiroyuki Okumura; Jun Hino; Kenji Mori; Fumiki Yoshihara; Shin-ichi Suga; Yuhei Kawano; Masakazu Kohno; Kenji Kangawa
Ventricular nonmyocytes inhibit doxorubicin-induced myocyte apoptosis: involvement of endogenous endothelin-1 as a paracrine factor.
Endocrinology 2004;145(5):2458-66.
2004: Yoshihiko Suzuki; Takeshi Horio; Tokio Hayashi; Hiroshi Nonogi; Kazuo Kitamura; Tanenao Eto; Kenji Kangawa; Yuhei Kawano
Plasma adrenomedullin concentration is increased in patients with peripheral arterial occlusive disease associated with vascular inflammation.
Regulatory peptides 2004;118(1-2):99-104.
2004: Pei Niu; Takayuki Shindo; Hiroshi Iwata; Satoshi Iimuro; Norifumi Takeda; Yuelan Zhang; Aya Ebihara; Yoshihiro Suematsu; Kenji Kangawa; Yasunobu Hirata; Ryozo Nagai
Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis, and renal damage.
Circulation 2004;109(14):1789-94.
2004: Yi Shi; Fumiki Yoshihara; Hajime Nakahama; Rieko Goto; Masaharu Sada; Yuhei Kawano; Toshiki Moriyama; Koji Yazawa; Naotsugu Ichimaru; Shiro Takahara; Kenji Kangawa
Mycophenolate mofetil prevents autoimmune glomerulonephritis and alterations of intrarenal adrenomedullin in rats.
European journal of pharmacology 2004;489(1-2):127-33.
2004: Lei Chen; Seiichi Hashida; Kazuo Kitamura; Tanenao Eto; Kenji Kangawa; Ryota Serino; Bela Kis; Hiroshi Yamashita; Yoichi Ueta
Disassociated increases of adrenomedullin in the rat cerebrospinal fluid and plasma after salt loading and systemic administration of lipopolysaccharide.
Peptides 2004;25(4):609-14.
2004: Takashi Akamizu; Kazuhiko Takaya; Taiga Irako; Hiroshi Hosoda; Satoshi Teramukai; Akiko Matsuyama; Harue Tada; Kazumi Miura; Akira Shimizu; Masanori Fukushima; Masayuki Yokode; Koichi Tanaka; Kenji Kangawa
Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects.
European journal of endocrinology / European Federation of Endocrine Societies 2004;150(4):447-55.
2004: Atsuro Miyata; Hideki Sugawara; Shin-ichi Iwata; Takao Shimizu; Kenji Kangawa
[The regulatory mechanism for neuron specific expression of PACAP gene].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2004;123(4):235-42.
2004: Noriyuki Tokunaga; Noritoshi Nagaya; Mikiyasu Shirai; Etsuro Tanaka; Hatsue Ishibashi-Ueda; Mariko Harada-Shiba; Munetake Kanda; Takefumi Ito; Wataru Shimizu; Yasuhiko Tabata; Masaaki Uematsu; Kazuhiro Nishigami; Shunji Sano; Kenji Kangawa; Hidezo Mori
Adrenomedullin gene transfer induces therapeutic angiogenesis in a rabbit model of chronic hind limb ischemia: benefits of a novel nonviral vector, gelatin.
Circulation 2004;109(4):526-31.
2004: Kazuhiko Shibata; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa; Yasuo Makino; Ikuko Makino; Tatsuhiko Kawarabayashi; Koujiro Futagami; Yutaka Gomita
Regulation of ghrelin secretion during pregnancy and lactation in the rat: possible involvement of hypothalamus.
Peptides 2004;25(2):279-87.
2004: Hidekazu Suzuki; Tatsuhiro Masaoka; Hiroshi Hosoda; Takayuki Ota; Yuriko Minegishi; Sachiko Nomura; Kenji Kangawa; Hiromasa Ishii
Helicobacter pylori infection modifies gastric and plasma ghrelin dynamics in Mongolian gerbils.
Gut 2004;53(2):187-94.
2004: Keita Hiragushi; Jun Wada; Jun Eguchi; Takashi Matsuoka; Akihiro Yasuhara; Izumi Hashimoto; Tetsuji Yamashita; Kazuyuki Hida; Yoshio Nakamura; Kenichi Shikata; Naoto Minamino; Kenji Kangawa; Hirofumi Makino
The role of adrenomedullin and receptors in glomerular hyperfiltration in streptozotocin-induced diabetic rats.
Kidney international 2004;65(2):540-50.
2004: Noritoshi Nagaya; Shingo Kyotani; Masaaki Uematsu; Kazuyuki Ueno; Hideo Oya; Norifumi Nakanishi; Mikiyasu Shirai; Hidezo Mori; Kunio Miyatake; Kenji Kangawa
Effects of adrenomedullin inhalation on hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension.
Circulation 2004;109(3):351-6.
2004: Hiroyuki Okumura; Noritoshi Nagaya; Takefumi Itoh; Ichiro Okano; Jun Hino; Kenji Mori; Yoshitane Tsukamoto; Hatsue Ishibashi-Ueda; Senri Miwa; Keiichi Tambara; Shinya Toyokuni; Chikao Yutani; Kenji Kangawa
Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway.
Circulation 2004;109(2):242-8.
2004: Shinkichi Kamata; Masafumi Kamiyama; Noriaki Usui; Yasuhiro Kitayama; Hiroomi Okuyama; Akio Kubota; Kenji Kangawa
Is adrenomedullin involved in the pathophysiology of persistent pulmonary hypertension of the newborn?
Pediatric surgery international 2004;20(1):24-6.
2004: Takeshi Hanada; Koji Toshinai; Yukari Date; Naoko Kajimura; Toshihiko Tsukada; Yujiro Hayashi; Kenji Kangawa; Masamitsu Nakazato
Upregulation of ghrelin expression in cachectic nude mice bearing human melanoma cells.
Metabolism: clinical and experimental 2004;53(1):84-8.
2004: Takefumi Itoh; Noritoshi Nagaya; Takafumi Fujii; Takashi Iwase; Norifumi Nakanishi; Kaoru Hamada; Kenji Kangawa; Hiroshi Kimura
A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats.
American journal of respiratory and critical care medicine 2004;169(1):34-8.
2003: Hiroyuki Kaiya; Masayasu Kojima; Hiroshi Hosoda; Shunsuke Moriyama; Akiyoshi Takahashi; Hiroshi Kawauchi; Kenji Kangawa
Peptide purification, complementary deoxyribonucleic acid (DNA) and genomic DNA cloning, and functional characterization of ghrelin in rainbow trout.
Endocrinology 2003;144(12):5215-26.
2003: Yuji Hataya; Takashi Akamizu; Hiroshi Hosoda; Naotetsu Kanamoto; Kenji Moriyama; Kenji Kangawa; Kazuhiko Takaya; Kazuwa Nakao
Alterations of plasma ghrelin levels in rats with lipopolysaccharide-induced wasting syndrome and effects of ghrelin treatment on the syndrome.
Endocrinology 2003;144(12):5365-71.
2003: Takeshi Hanada; Yukari Date; Takuya Shimbara; Satoru Sakihara; Noboru Murakami; Yujiro Hayashi; Yasushi Kanai; Toshihiro Suda; Kenji Kangawa; Masamitsu Nakazato
Central actions of neuromedin U via corticotropin-releasing hormone.
Biochemical and biophysical research communications 2003;311(4):954-8.
2003: Seiko Kitamura; Ichiro Yokota; Hiroshi Hosoda; Yumiko Kotani; Juzo Matsuda; Etsuo Naito; Michinori Ito; Kenji Kangawa; Yasuhiro Kuroda
Ghrelin concentration in cord and neonatal blood: relation to fetal growth and energy balance.
The Journal of clinical endocrinology and metabolism 2003;88(11):5473-7.
2003: Toshio Nishikimi; Fumiki Yoshihara; Shigeo Horinaka; Naohiko Kobayashi; Yosuke Mori; Kazuyoshi Tadokoro; Kazumi Akimoto; Naoto Minamino; Kenji Kangawa; Hiroaki Matsuoka
Chronic administration of adrenomedullin attenuates transition from left ventricular hypertrophy to heart failure in rats.
Hypertension 2003;42(5):1034-41.
2003: Noritoshi Nagaya; Hiroyuki Okumura; Masaaki Uematsu; Wataru Shimizu; Fumiaki Ono; Mikiyasu Shirai; Hidezo Mori; Kunio Miyatake; Kenji Kangawa
Repeated inhalation of adrenomedullin ameliorates pulmonary hypertension and survival in monocrotaline rats.
American journal of physiology. Heart and circulatory physiology 2003;285(5):H2125-31.
2003: Ken Watanabe; Toshio Nishikimi; Motoki Takamuro; Kenji Yasuda; Yuichi Ishikawa; S Tanabe; Osamu Yamada; N Nagaya; Hiroaki Matsuoka; Kenji Kangawa; Shigeyuki Echigo
Two molecular forms of adrenomedullin in congenital heart disease.
Pediatric cardiology 2003;24(6):559-65.
2003: Yoshito Shimizu; Noritoshi Nagaya; Yasuhiro Teranishi; Michinori Imazu; Hideya Yamamoto; Tomoki Shokawa; Kenji Kangawa; Nobuoki Kohno; Masao Yoshizumi
Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats.
Biochemical and biophysical research communications 2003;310(3):830-5.
2003: Mitsunobu Enomoto; Noritoshi Nagaya; Masaaki Uematsu; Hiroyuki Okumura; Eiichiroh Nakagawa; Fumiaki Ono; Hiroshi Hosoda; Hideo Oya; Masayasu Kojima; Katsuo Kanmatsuse; Kenji Kangawa
Cardiovascular and hormonal effects of subcutaneous administration of ghrelin, a novel growth hormone-releasing peptide, in healthy humans.
Clinical science (London, England : 1979) 2003;105(4):431-5.
2003: Kisaburo Nagamune; Kazuhito Ohishi; Hisashi Ashida; Yeonchul Hong; Jun Hino; Kenji Kangawa; Norimitsu Inoue; Yusuke Maeda; Taroh Kinoshita
GPI transamidase of Trypanosoma brucei has two previously uncharacterized (trypanosomatid transamidase 1 and 2) and three common subunits.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10682-7.
2003: Noritoshi Nagaya; Kenji Kangawa; Munetake Kanda; Masaaki Uematsu; Takeshi Horio; Naoto Fukuyama; Jun Hino; Mariko Harada-Shiba; Hiroyuki Okumura; Yasuhiko Tabata; Naoki Mochizuki; Yoshihide Chiba; Keisuke Nishioka; Kunio Miyatake; Takayuki Asahara; Hiroshi Hara; Hidezo Mori
Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells.
Circulation 2003;108(7):889-95.
2003: Jun Hino; Shin-ichiro NISHIMATSU; Takeharu Nagai; Hisayuki Matsuo; Kenji Kangawa; Tsutomu Nohno
Coordination of BMP-3b and cerberus is required for head formation of Xenopus embryos.
Developmental biology 2003;260(1):138-57.
2003: Noritoshi Nagaya; Kenji Kangawa
Ghrelin, a novel growth hormone-releasing peptide, in the treatment of chronic heart failure.
Regulatory peptides 2003;114(2-3):71-7.
2003: Hiroshi Hosoda; Kenji Kangawa
[Ghrelin and GH secretion].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2003;40(4):341-3.
2003: Hiroyuki Kaiya; Masayasu Kojima; Hiroshi Hosoda; Larry G Riley; Tetsuya Hirano; E Gordon Grau; Kenji Kangawa
Identification of tilapia ghrelin and its effects on growth hormone and prolactin release in the tilapia, Oreochromis mossambicus.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2003;135(3):421-9.
2003: Yoshikatsu Nakai; Hiroshi Hosoda; Kazuko Nin; Chizuru Ooya; Hiromi Hayashi; Takashi Akamizu; Kenji Kangawa
Plasma levels of active form of ghrelin during oral glucose tolerance test in patients with anorexia nervosa.
European journal of endocrinology / European Federation of Endocrine Societies 2003;149(1):R1-3.
2003: Minami Abe; Masataka Sata; Hiroaki Nishimatsu; Daisuke Nagata; Etsu Suzuki; Yasuo Terauchi; Takashi Kadowaki; Naoto Minamino; Kenji Kangawa; Hisayuki Matsuo; Yasunobu Hirata; Ryozo Nagai
Adrenomedullin augments collateral development in response to acute ischemia.
Biochemical and biophysical research communications 2003;306(1):10-5.
2003: Tsutomu Hashizume; Mami Horiuchi; Naomi Tate; Sumie Nonaka; Masayasu Kojima; Hiroshi Hosoda; Kenji Kangawa
Effects of ghrelin on growth hormone secretion from cultured adenohypophysial cells in cattle.
Endocrine journal 2003;50(3):289-95.
2003: Toshihiko Ishimitsu; Kohju Tsukada; Junichi Minami; Hidehiko Ono; Masami Ohrui; Jun Hino; Kenji Kangawa; Hiroaki Matsuoka
Microsatellite DNA polymorphism of human adrenomedullin gene in type 2 diabetic patients with renal failure.
Kidney international 2003;63(6):2230-5.
2003: Takeshi Horio; Takeshi Tokudome; Toshiyuki Maki; Fumiki Yoshihara; Shin-ichi Suga; Toshio Nishikimi; Masayasu Kojima; Yuhei Kawano; Kenji Kangawa
Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts.
Endocrinology 2003;144(6):2279-84.
2003: Muhtashan S Mondal; Yukari Date; Noboru Murakami; Koji Toshinai; Takuya Shimbara; Kenji Kangawa; Masamitsu Nakazato
Neuromedin U acts in the central nervous system to inhibit gastric acid secretion via CRH system.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(6):G963-9.
2003: Ichiro Sakata; Mami Yamazaki; Kinji Inoue; Yujiro Hayashi; Kenji Kangawa; Takafumi Sakai
Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion.
Neuroscience letters 2003;342(3):183-6.
2003: Toshihisa Sugino; Junji Yamaura; Masako Yamagishi; Yohei Kurose; Masayasu Kojima; Kenji Kangawa; Yoshihisa Hasegawa; Yoshiaki Terashima
Involvement of cholinergic neurons in the regulation of the ghrelin secretory response to feeding in sheep.
Biochemical and biophysical research communications 2003;304(2):308-12.
2003: Keisuke Tanaka; Hiroyuki Minoura; Tetsuya Isobe; Hitoshi Yonaha; Hiroaki Kawato; Dong Fang Wang; Toshimichi Yoshida; Masayasu Kojima; Kenji Kangawa; Nagayasu Toyoda
Ghrelin is involved in the decidualization of human endometrial stromal cells.
The Journal of clinical endocrinology and metabolism 2003;88(5):2335-40.
2003: Tatsuhiro Masaoka; Hidekazu Suzuki; Hiroshi Hosoda; Takayuki Ota; Yuriko Minegishi; Hiroshi Nagata; Kenji Kangawa; Hiromasa Ishii
Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes.
FEBS letters 2003;541(1-3):64-8.
2003: Yasuhiko Okimura; Kiyoharu Ukai; Hiroshi Hosoda; Masahiro Murata; Genzo Iguchi; Keiji Iida; Hiroshi Kaji; Masayasu Kojima; Kenji Kangawa; Kazuo Chihara
The role of circulating ghrelin in growth hormone (GH) secretion in freely moving male rats.
Life sciences 2003;72(22):2517-24.
2003: Keiko Nakahara; Takahiro Hayashida; Masamitsu Nakazato; Masayasu Kojima; Hiroshi Hosoda; Kenji Kangawa; Noboru Murakami
Effect of chronic treatments with ghrelin on milk secretion in lactating rats.
Biochemical and biophysical research communications 2003;303(3):751-5.
2003: Takeshi Katafuchi; Katsuro Kikumoto; Kazumasa Hamano; Kenji Kangawa; Hisayuki Matsuo; Naoto Minamino
Calcitonin receptor-stimulating peptide, a new member of the calcitonin gene-related peptide family. Its isolation from porcine brain, structure, tissue distribution, and biological activity.
The Journal of biological chemistry 2003;278(14):12046-54.
2003: Noritoshi Nagaya; Kenji Kangawa
Ghrelin improves left ventricular dysfunction and cardiac cachexia in heart failure.
Current opinion in pharmacology 2003;3(2):146-51.
2003: Hiroto Takeuchi; Koji Ohmori; Isao Kondo; Akira Oshita; Kaori Shinomiya; Yang Yu; Yuichiro Takagi; Katsufumi Mizushige; Kenji Kangawa; Masakazu Kohno
Potentiation of C-type natriuretic peptide with ultrasound and microbubbles to prevent neointimal formation after vascular injury in rats.
Cardiovascular research 2003;58(1):231-8.
2003: Koji Toshinai; Yukari Date; Noboru Murakami; Mitsushi Shimada; Muhtashan S Mondal; Takuya Shimbara; Jian-Lian Guan; Qing-Ping Wang; Hisayuki Funahashi; Takeshi Sakurai; Seiji Shioda; Shigeru Matsukura; Kenji Kangawa; Masamitsu Nakazato
Ghrelin-induced food intake is mediated via the orexin pathway.
Endocrinology 2003;144(4):1506-12.
2003: Reiko Wada; Ichiro Sakata; Hiroyuki Kaiya; Kazuaki Nakamura; Yujiro Hayashi; Kenji Kangawa; Takafumi Sakai
Existence of ghrelin-immunopositive and -expressing cells in the proventriculus of the hatching and adult chicken.
Regulatory peptides 2003;111(1-3):123-8.
2003: Mitsushi Shimada; Yukari Date; Muhtashan S Mondal; Koji Toshinai; Takuya Shimbara; Kyoko Fukunaga; Noboru Murakami; Mikiya Miyazato; Kenji Kangawa; Hironobu Yoshimatsu; Hisayuki Matsuo; Masamitsu Nakazato
Somatostatin suppresses ghrelin secretion from the rat stomach.
Biochemical and biophysical research communications 2003;302(3):520-5.
2003: Hiroyuki Kaiya; Masayasu Kojima; Hiroshi Hosoda; Larry G Riley; Tetsuya Hirano; E Gordon Grau; Kenji Kangawa
Amidated fish ghrelin: purification, cDNA cloning in the Japanese eel and its biological activity.
The Journal of endocrinology 2003;176(3):415-23.
2003: Toshio Nishikimi; Kazuyoshi Tadokoro; Yosuke Mori; Xin Wang; Kazumi Akimoto; Fumiki Yoshihara; Naoto Minamino; Kenji Kangawa; Hiroaki Matsuoka
Ventricular adrenomedullin system in the transition from LVH to heart failure in rats.
Hypertension 2003;41(3):512-8.
2003: Kichoon Choi; Sang-Gun Roh; Yeon-Hee Hong; Yogendra B Shrestha; Daisuke Hishikawa; Chen Chen; Masayasu Kojima; Kenji Kangawa; Shin-Ichi Sasaki
The role of ghrelin and growth hormone secretagogues receptor on rat adipogenesis.
Endocrinology 2003;144(3):754-9.
2003: Ikuko Makino; Yasuo Makino; Fumiki Yoshihara; Toshio Nishikimi; Tatsuhiko Kawarabayashi; Kenji Kangawa; Kazuhiko Shibata
Decreased mature adrenomedullin levels in feto-maternal tissues of pregnant women with histologic chorioamnionitis.
Biochemical and biophysical research communications 2003;301(2):437-42.
2003: Takeshi Hanada; Koji Toshinai; Naoko Kajimura; Noriko Nara-Ashizawa; Toshihiko Tsukada; Yujiro Hayashi; Kazuhiro Osuye; Kenji Kangawa; Shigeru Matsukura; Masamitsu Nakazato
Anti-cachectic effect of ghrelin in nude mice bearing human melanoma cells.
Biochemical and biophysical research communications 2003;301(2):275-9.
2003: Noritoshi Nagaya; Kunio Miyatake; Shingo Kyotani; Toshio Nishikimi; Norifumi Nakanishi; Kenji Kangawa
Pulmonary vasodilator response to adrenomedullin in patients with pulmonary hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26 Suppl():S141-6.
2003: Toshio Nishikimi; Fumiki Yoshihara; Yosuke Mori; Kenji Kangawa; Hiroaki Matsuoka
Cardioprotective effect of adrenomedullin in heart failure.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26 Suppl():S121-7.
2003: Hiroyuki Okumura; Noritoshi Nagaya; Kenji Kangawa
Adrenomedullin infusion during ischemia/reperfusion attenuates left ventricular remodeling and myocardial fibrosis in rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26 Suppl():S99-104.
2003: Hiroaki Nishimatsu; Yasunobu Hirata; Takayuki Shindo; Hiroki Kurihara; Etsu Suzuki; Masataka Sata; Hiroshi Satonaka; Ryo Takeda; Daisuke Nagata; Masao Kakoki; Hiroshi Hayakawa; Kenji Kangawa; Hisayuki Matsuo; Tadaichi Kitamura; Ryozo Nagai
Endothelial responses of the aorta from adrenomedullin transgenic mice and knockout mice.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26 Suppl():S79-84.
2003: Junichi Yamaga; Seiichi Hashida; Kazuo Kitamura; Mariko Tokashiki; Toshihiro Aoki; Haruhiko Inatsu; Naoto Ishikawa; Kenji Kangawa; Kazuhiro Morishita; Tanenao Eto
Direct measurement of glycine-extended adrenomedullin in plasma and tissue using an ultrasensitive immune complex transfer enzyme immunoassay in rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26 Suppl():S45-53.
2003: Yoshito Shimizu; Noritoshi Nagaya; Takeshi Isobe; Michinori Imazu; Hiroyuki Okumura; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa; Nobuoki Kohno
Increased plasma ghrelin level in lung cancer cachexia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(2):774-8.
2003: Shin-ichi Suga; Naomi Yasui; Fumiki Yoshihara; Takeshi Horio; Yuhei Kawano; Kenji Kangawa; Richard J Johnson
Endothelin a receptor blockade and endothelin B receptor blockade improve hypokalemic nephropathy by different mechanisms.
Journal of the American Society of Nephrology : JASN 2003;14(2):397-406.
2003: Hiroshi Hosoda; Masayasu Kojima; Tsunekazu Mizushima; Shigeomi Shimizu; Kenji Kangawa
Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing.
The Journal of biological chemistry 2003;278(1):64-70.
2002: Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa
Ghrelin and the regulation of food intake and energy balance.
Molecular interventions 2002;2(8):494-503.
2002: Masayasu Kojima; Kenji Kangawa
Ghrelin, an orexigenic signaling molecule from the gastrointestinal tract.
Current opinion in pharmacology 2002;2(6):665-8.
2002: Ayako Ikezaki; Hiroshi Hosoda; Keiko Ito; Saika Iwama; Naoko Miura; Hisafumi Matsuoka; Chisato Kondo; Masayasu Kojima; Kenji Kangawa; Shigetaka Sugihara
Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents.
Diabetes 2002;51(12):3408-11.
2002: Ryosai Nakamura; Johji Kato; Kazuo Kitamura; Hisamitsu Onitsuka; Takuroh Imamura; Kousuke Marutsuka; Yujiro Asada; Kenji Kangawa; Tanenao Eto
Beneficial effects of adrenomedullin on left ventricular remodeling after myocardial infarction in rats.
Cardiovascular research 2002;56(3):373-80.
2002: Toshihisa Sugino; Junji Yamaura; Masako Yamagishi; Atsushi Ogura; Reiko Hayashi; Yohei Kurose; Masayasu Kojima; Kenji Kangawa; Yoshihisa Hasegawa; Yoshiaki Terashima
A transient surge of ghrelin secretion before feeding is modified by different feeding regimens in sheep.
Biochemical and biophysical research communications 2002;298(5):785-8.
2002: Hirofumi Sano; Atsuro Miyata; Takeshi Horio; Toshio Nishikimi; Hisayuki Matsuo; Kenji Kangawa
The effect of pituitary adenylate cyclase activating polypeptide on cultured rat cardiocytes as a cardioprotective factor.
Regulatory peptides 2002;109(1-3):107-13.
2002: Johji Kato; Kazuo Kitamura; Tomohiko Uemura; Kenji Kuwasako; Toshihiro Kita; Kenji Kangawa; Tanenao Eto
Plasma levels of adrenomedullin and atrial and brain natriuretic peptides in the general population: their relations to age and pulse pressure.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(6):887-92.
2002: Junichi Minami; Toshio Nishikimi; Masakatsu Todoroki; Chieko Kashiwakura; Hiroshi Yagi; Hidehiko Ono; Shigeo Horinaka; Toshihiko Ishimitsu; Kenji Kangawa; Hiroaki Matsuoka
Source of plasma adrenomedullin in patients with pheochromocytoma.
American journal of hypertension 2002;15(11):994-7.
2002: Hiroshi Iwakura; Kiminori Hosoda; Ryuichiro Doi; Izumi Komoto; Haruo Nishimura; Choel Son; Junji Fujikura; Tsutomu Tomita; Kazuhiko Takaya; Yoshihiro Ogawa; Tatsuya Hayashi; Gen Inoue; Takashi Akamizu; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa; Masayuki Imamura; Kazuwa Nakao
Ghrelin expression in islet cell tumors: augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I.
The Journal of clinical endocrinology and metabolism 2002;87(11):4885-8.
2002: Akihiro Yoshimoto; Kiyoshi Mori; Akira Sugawara; Masashi Mukoyama; Kensei Yahata; Takayoshi Suganami; Kazuhiko Takaya; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa; Kazuwa Nakao
Plasma ghrelin and desacyl ghrelin concentrations in renal failure.
Journal of the American Society of Nephrology : JASN 2002;13(11):2748-52.
2002: Ei-Suke Saito; Hiroyuki Kaiya; Tomo Takagi; Izumi Yamasaki; D Michael Denbow; Kenji Kangawa; Mitsuhiro Furuse
Chicken ghrelin and growth hormone-releasing peptide-2 inhibit food intake of neonatal chicks.
European journal of pharmacology 2002;453(1):75-9.
2002: Yukari Date; Noboru Murakami; Koji Toshinai; Shigeru Matsukura; Akira Niijima; Hisayuki Matsuo; Kenji Kangawa; Masamitsu Nakazato
The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats.
Gastroenterology 2002;123(4):1120-8.
2002: Helene Nørrelund; Troels Krarup Hansen; Hans Ørskov; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa; Jørgen Weeke; Niels Møller; Jens Sandahl Christiansen; Jens Otto Lunde Jørgensen
Ghrelin immunoreactivity in human plasma is suppressed by somatostatin.
Clinical endocrinology 2002;57(4):539-46.
2002: Suraj Unniappan; Xinwei Lin; Laura Cervini; Jean Rivier; Hiroyuki Kaiya; Kenji Kangawa; Richard E Peter
Goldfish ghrelin: molecular characterization of the complementary deoxyribonucleic acid, partial gene structure and evidence for its stimulatory role in food intake.
Endocrinology 2002;143(10):4143-6.
2002: Ichiro Sakata; Toru Tanaka; Maki Matsubara; Mami Yamazaki; S Tani; Yuijiro Hayashi; Kenji Kangawa; Takafumi Sakai
Postnatal changes in ghrelin mRNA expression and in ghrelin-producing cells in the rat stomach.
The Journal of endocrinology 2002;174(3):463-71.
2002: Takeshi Tokudome; Takeshi Horio; Fumiki Yoshihara; Shin-ichi Suga; Yuhei Kawano; Masakazu Kohno; Kenji Kangawa
Adrenomedullin inhibits doxorubicin-induced cultured rat cardiac myocyte apoptosis via a cAMP-dependent mechanism.
Endocrinology 2002;143(9):3515-21.
2002: Hiroyuki Kaiya; Serge Van Der Geyten; Masayasu Kojima; Hiroshi Hosoda; Yasuo Kitajima; Masaru Matsumoto; Sofie M E Geelissen; Veerle M Darras; Kenji Kangawa
Chicken ghrelin: purification, cDNA cloning, and biological activity.
Endocrinology 2002;143(9):3454-63.
2002: Hiroyuki Ariyasu; Kazuhiko Takaya; Hiroshi Hosoda; Hiroshi Iwakura; Ken Ebihara; Kiyoshi Mori; Yoshihiro Ogawa; Kiminori Hosoda; Takashi Akamizu; Masayasu Kojima; Kenji Kangawa; Kazuwa Nakao
Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin.
Endocrinology 2002;143(9):3341-50.
2002: Eiichiro Nakagawa; Noritoshi Nagaya; Hiroyuki Okumura; Mitsunobu Enomoto; Hideo Oya; Fumiaki Ono; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa
Hyperglycaemia suppresses the secretion of ghrelin, a novel growth-hormone-releasing peptide: responses to the intravenous and oral administration of glucose.
Clinical science (London, England : 1979) 2002;103(3):325-8.
2002: Ludovic Galas; Nicolas Chartrel; Masayasu Kojima; Kenji Kangawa; Hubert Vaudry
Immunohistochemical localization and biochemical characterization of ghrelin in the brain and stomach of the frog Rana esculenta.
The Journal of comparative neurology 2002;450(1):34-44.
2002: Noboru Murakami; Takahiro Hayashida; T Kuroiwa; Keiko Nakahara; T Ida; MS Mondal; Masamitsu Nakazato; Masayasu Kojima; Kenji Kangawa
Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats.
The Journal of endocrinology 2002;174(2):283-8.
2002: Yasushi Imai; Takayuki Shindo; Koji Maemura; Masataka Sata; Yuichiro Saito; Yukiko Kurihara; Masahiro Akishita; Jun-ichi Osuga; Shun Ishibashi; Kazuyuki Tobe; Hiroyuki Morita; Yoshio Oh-hashi; Toru Suzuki; Hiromitsu Maekawa; Kenji Kangawa; Naoto Minamino; Yoshio Yazaki; Ryozo Nagai; Hiroki Kurihara
Resistance to neointimal hyperplasia and fatty streak formation in mice with adrenomedullin overexpression.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(8):1310-5.
2002: Toshihisa Sugino; Yoshihisa Hasegawa; Y Kikkawa; Junji Yamaura; Masako Yamagishi; Yohei Kurose; Masayasu Kojima; Kenji Kangawa; Yoshiaki Terashima
A transient ghrelin surge occurs just before feeding in a scheduled meal-fed sheep.
Biochemical and biophysical research communications 2002;295(2):255-60.
2002: Fumiki Yoshihara; Masayasu Kojima; Hiroshi Hosoda; Masamitsu Nakazato; Kenji Kangawa
Ghrelin: a novel peptide for growth hormone release and feeding regulation.
Current opinion in clinical nutrition and metabolic care 2002;5(4):391-5.
2002: Yosuke Mori; Toshio Nishikimi; Naohiko Kobayashi; Hidehiko Ono; Kenji Kangawa; Hiroaki Matsuoka
Long-term adrenomedullin infusion improves survival in malignant hypertensive rats.
Hypertension 2002;40(1):107-13.
2002: Rolf Dall; Jill A Kanaley; Troels Krarup Hansen; Niels Møller; Jens Sandahl Christiansen; Hiroshi Hosoda; Kenji Kangawa; Jens Otto Lunde Jørgensen
Plasma ghrelin levels during exercise in healthy subjects and in growth hormone-deficient patients.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(1):65-70.
2002: Toshio Nishikimi; Yosuke Mori; Naohiko Kobayashi; Kazuyoshi Tadokoro; Xin Wang; Kazumi Akimoto; Fumiki Yoshihara; Kenji Kangawa; Hiroaki Matsuoka
Renoprotective effect of chronic adrenomedullin infusion in Dahl salt-sensitive rats.
Hypertension 2002;39(6):1077-82.
2002: Toshio Nishikimi; Ikuko Shibasaki; Hiroshi Iida; Hiroshi Asakawa; Yasushi Matsushita; Hideaki Mori; Yoshihiko Mochizuki; Yoshitaka Okamura; Shigeo Horinaka; Kenji Kangawa; Koichiro Shimada; Hiroaki Matsuoka
Molecular forms of adrenomedullin in pericardial fluid and plasma in patients with ischaemic heart disease.
Clinical science (London, England : 1979) 2002;102(6):669-77.
2002: Tomohiko Uemura; Johji Kato; Kenji Kuwasako; Kazuo Kitamura; Kenji Kangawa; Tanenao Eto
Aldosterone augments adrenomedullin production without stimulating pro-adrenomedullin N-terminal 20 peptide secretion in vascular smooth muscle cells.
Journal of hypertension 2002;20(6):1209-14.
2002: Satoshi Yasuda; Masahiko Kanna; Satoru Sakuragi; Sunao Kojima; Yasuhide Nakayama; Shunichi Miyazaki; Takehisa Matsuda; Kenji Kangawa; Hiroshi Nonogi
Local delivery of single low-dose of C-type natriuretic peptide, an endogenous vascular modulator, inhibits neointimal hyperplasia in a balloon-injured rabbit iliac artery model.
Journal of cardiovascular pharmacology 2002;39(6):784-8.
2002: Hiroyuki Okumura; Noritoshi Nagaya; Mitsunobu Enomoto; Eiichiroh Nakagawa; Hideo Oya; Kenji Kangawa
Vasodilatory effect of ghrelin, an endogenous peptide from the stomach.
Journal of cardiovascular pharmacology 2002;39(6):779-83.
2002: Takahiro Hayashida; Keiko Nakahara; MS Mondal; Yukari Date; Masamitsu Nakazato; Masayasu Kojima; Kenji Kangawa; Noboru Murakami
Ghrelin in neonatal rats: distribution in stomach and its possible role.
The Journal of endocrinology 2002;173(2):239-45.
2002: Noritoshi Nagaya; Yoichi Goto; Toru Satoh; Hitoshi Sumida; Sunao Kojima; Kunio Miyatake; Kenji Kangawa
Intravenous adrenomedullin in myocardial function and energy metabolism in patients after myocardial infarction.
Journal of cardiovascular pharmacology 2002;39(5):754-60.
2002: Chunping Chu; Qinghua Jin; Takato Kunitake; Kazuo Kato; Takashi Nabekura; Masamitsu Nakazato; Kenji Kangawa; Hiroshi Kannan
Cardiovascular actions of central neuromedin U in conscious rats.
Regulatory peptides 2002;105(1):29-34.
2002: Hiroaki Nishimatsu; Yasunobu Hirata; Takayuki Shindo; Hiroki Kurihara; Masao Kakoki; Daisuke Nagata; Hiroshi Hayakawa; Hiroshi Satonaka; Masataka Sata; Arinobu Tojo; Etsu Suzuki; Kenji Kangawa; Hisayuki Matsuo; Tadaichi Kitamura; Ryozo Nagai
Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene.
Circulation research 2002;90(6):657-63.
2002: Bela Kis; H Kaiya; R Nishi; Mária A Deli; Csongor S Abrahám; T Yanagita; Toyohi Isse; Sadao Gotoh; H Kobayashi; A Wada; M Niwa; Kenji Kangawa; J Greenwood; Hiroshi Yamashita; Yoichi Ueta
Cerebral endothelial cells are a major source of adrenomedullin.
Journal of neuroendocrinology 2002;14(4):283-93.
2002: Kazuo Kitamura; Kenji Kangawa; Tanenao Eto
Adrenomedullin and PAMP: discovery, structures, and cardiovascular functions.
Microscopy research and technique 2002;57(1):3-13.
2002: S Lu; Jian-Lian Guan; Qing-Ping Wang; Kichiro Uehara; Shuori Yamada; N Goto; Yukari Date; Masamitsu Nakazato; M Kojima; Kenji Kangawa; Seiji Shioda
Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus.
Neuroscience letters 2002;321(3):157-60.
2002: Naomi Tanikawa; Yoshihiro Ohmiya; Hiroaki Ohkubo; Katsuyuki Hashimoto; Kenji Kangawa; Masami Kojima; Seiji Ito; Kikuko Watanabe
Identification and characterization of a novel type of membrane-associated prostaglandin E synthase.
Biochemical and biophysical research communications 2002;291(4):884-9.
2002: Yasuo Makino; Hiroshi Hosoda; Kazuhiko Shibata; Ikuko Makino; Masayasu Kojima; Kenji Kangawa; Tatsuhiko Kawarabayashi
Alteration of plasma ghrelin levels associated with the blood pressure in pregnancy.
Hypertension 2002;39(3):781-4.
2002: Keiichi Tambara; Masatoshi Fujita; Noritoshi Nagaya; Shoichi Miyamoto; Atsushi Iwakura; Kentaro Doi; Genichi Sakaguchi; Kazunobu Nishimura; Kenji Kangawa; Masashi Komeda
Increased pericardial fluid concentrations of the mature form of adrenomedullin in patients with cardiac remodelling.
Heart (British Cardiac Society) 2002;87(3):242-6.
2002: Ichiro Sakata; Kazuaki Nakamura; Mami Yamazaki; Maki Matsubara; Yuijiro Hayashi; Kenji Kangawa; Takafumi Sakai
Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract.
Peptides 2002;23(3):531-6.
2002: Masahiro Murata; Yasuhiko Okimura; Keiji Iida; Michihiro Matsumoto; Hideaki Sowa; Hiroshi Kaji; Masayasu Kojima; Kenji Kangawa; Kazuo Chihara
Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells.
The Journal of biological chemistry 2002;277(7):5667-74.
2002: Troels Krarup Hansen; Rolf Dall; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa; Jens Sandahl Christiansen; Jens Otto Lunde Jørgensen
Weight loss increases circulating levels of ghrelin in human obesity.
Clinical endocrinology 2002;56(2):203-6.
2002: Mami Yamazaki; Kazuaki Nakamura; H Kobayashi; Maki Matsubara; Yuijiro Hayashi; Kenji Kangawa; Takafumi Sakai
Regulational effect of ghrelin on growth hormone secretion from perifused rat anterior pituitary cells.
Journal of neuroendocrinology 2002;14(2):156-62.
2002: Fumiki Yoshihara; Takeshi Horio; Toshio Nishikimi; Hisayuki Matsuo; Kenji Kangawa
Possible involvement of oxidative stress in hypoxia-induced adrenomedullin secretion in cultured rat cardiomyocytes.
European journal of pharmacology 2002;436(1-2):1-6.
2002: Fumiki Yoshihara; Toshio Nishikimi; Yoshikado Sasako; Jun Hino; Junjiro Kobayashi; Kenji Minatoya; Ko Bando; Yoshio Kosakai; Takeshi Horio; Shin-ichi Suga; Yuhei Kawano; Hiroaki Matsuoka; Chikao Yutani; Hisayuki Matsuo; Soichiro Kitamura; Tohru Ohe; Kenji Kangawa
Plasma atrial natriuretic peptide concentration inversely correlates with left atrial collagen volume fraction in patients with atrial fibrillation: plasma ANP as a possible biochemical marker to predict the outcome of the maze procedure.
Journal of the American College of Cardiology 2002;39(2):288-94.
2002: Tomomi Shiiya; Masamitsu Nakazato; Masanari Mizuta; Yukari Date; Muhtashan S Mondal; Muneki Tanaka; Shin-ichi Nozoe; Hiroshi Hosoda; Kenji Kangawa; Shigeru Matsukura
Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion.
The Journal of clinical endocrinology and metabolism 2002;87(1):240-4.
2002: Tatsuo Shimosawa; Yugo Shibagaki; Kotaro Ishibashi; Kazuo Kitamura; Kenji Kangawa; Shigeaki Kato; Katsuyuki Ando; Toshiro Fujita
Adrenomedullin, an endogenous peptide, counteracts cardiovascular damage.
Circulation 2002;105(1):106-11.
2002: Yukari Date; Masamitsu Nakazato; Suzuko Hashiguchi; Katsuya Dezaki; Muhtashan S Mondal; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa; Terukatsu Arima; Hisayuki Matsuo; Toshihiko Yada; Shigeru Matsukura
Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion.
Diabetes 2002;51(1):124-9.
2001: Bela Kis; Mária A Deli; H Kobayashi; Csongor S Abrahám; T Yanagita; H Kaiya; Toyohi Isse; R Nishi; Sadao Gotoh; Kenji Kangawa; A Wada; John Greenwood; M Niwa; Hiroshi Yamashita; Yoichi Ueta
Adrenomedullin regulates blood-brain barrier functions in vitro.
Neuroreport 2001;12(18):4139-42.
2001: Noritoshi Nagaya; Kunio Miyatake; Masaaki Uematsu; Hideo Oya; Wataru Shimizu; Hiroshi Hosoda; Masayasu Kojima; N Nakanishi; Hidezo Mori; Kenji Kangawa
Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure.
The Journal of clinical endocrinology and metabolism 2001;86(12):5854-9.
2001: Toshio Nishikimi; Fumiki Yoshihara; A Kanazawa; Ichiro Okano; Takeshi Horio; Noritoshi Nagaya; Chikao Yutani; Hisayuki Matsuo; Hiroaki Matsuoka; Kenji Kangawa
Role of increased circulating and renal adrenomedullin in rats with malignant hypertension.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(6):R2079-87.
2001: Ikuko Makino; Kenji Honda; Yasuo Makino; I Okano; Kenji Kangawa; H Kamiya; Kazuhiko Shibata; Tatsuhiko Kawarabayashi
Phenotypic changes of adrenomedullin receptor components, RAMP2, and CRLR mRNA expression in cultured rat vascular smooth muscle cells.
Biochemical and biophysical research communications 2001;288(3):515-20.
2001: Hiroyuki Kaiya; Masayasu Kojima; Hiroshi Hosoda; A Koda; K Yamamoto; Y Kitajima; M Matsumoto; Y Minamitake; Sakae Kikuyama; Kenji Kangawa
Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue.
The Journal of biological chemistry 2001;276(44):40441-8.
2001: Toshio Nishikimi; M Junichi; T Yasu; S Takeshi; Kenji Kangawa; Hiroaki Matsuoka
Two molecular forms of plasma adrenomedullin during tilt test in healthy subjects.
Peptides 2001;22(11):1867-72.
2001: Yoichi Ueta; Y Hara; Kazuo Kitamura; Kenji Kangawa; Tanenao Eto; Y Hattori; Hiroshi Yamashita
Action sites of adrenomedullin in the rat brain: functional mapping by Fos expression.
Peptides 2001;22(11):1817-24.
2001: Toshihiko Ishimitsu; K Hosoya; Kohju Tsukada; Junichi Minami; Hidehiko Ono; Masami Ohrui; Jun Hino; Kenji Kangawa; Hiroaki Matsuoka
Chromosomal sublocalization and microsatellite DNA polymorphism of human adrenomedullin gene.
Peptides 2001;22(11):1739-44.
2001: Kazuo Kitamura; Eizaburo Matsui; Johji Kato; F Katoh; Toshihiro Kita; T Tsuji; Kenji Kangawa; Tanenao Eto
Adrenomedullin (11-26): a novel endogenous hypertensive peptide isolated from bovine adrenal medulla.
Peptides 2001;22(11):1713-8.
2001: Noritoshi Nagaya; Masaaki Uematsu; Masayasu Kojima; Y Date; M Nakazato; Hiroyuki Okumura; Hiroshi Hosoda; Wataru Shimizu; M Yamagishi; Hideo Oya; H Koh; C Yutani; Kenji Kangawa
Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors.
Circulation 2001;104(17):2034-8.
2001: Takayuki Shindo; Yukiko Kurihara; Hiroaki Nishimatsu; Nobuo Moriyama; Masao Kakoki; Y Wang; Yasuharu Imai; Aya Ebihara; Tomoyuki Kuwaki; Kihwan Ju; Naoto Minamino; Kenji Kangawa; T Ishikawa; M Fukuda; Y Akimoto; H Kawakami; T Imai; Hiroyuki Morita; Yoshio Yazaki; Ryozo Nagai; Yasunobu Hirata; Hiroki Kurihara
Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.
Circulation 2001;104(16):1964-71.
2001: Yasuo Makino; Kazuhiko Shibata; Ikuko Makino; Kenji Kangawa; Tatsuhiko Kawarabayashi
Alteration of the adrenomedullin receptor components gene expression associated with the blood pressure in pregnancy-induced hypertension.
The Journal of clinical endocrinology and metabolism 2001;86(10):5079-82.
2001: Naotetsu Kanamoto; Takashi Akamizu; Hiroshi Hosoda; Yuji Hataya; Hiroyuki Ariyasu; Kazuhiko Takaya; Kiminori Hosoda; Misa Saijo; Kenji Moriyama; Akira Shimatsu; Masayasu Kojima; Kenji Kangawa; Kazuwa Nakao
Substantial production of ghrelin by a human medullary thyroid carcinoma cell line.
The Journal of clinical endocrinology and metabolism 2001;86(10):4984-90.
2001: Hiroyuki Ariyasu; Kazuhiko Takaya; Tetsuya Tagami; Yoshihiro Ogawa; Kiminori Hosoda; Takashi Akamizu; Michio Suda; T Koh; Koshi Natsui; S Toyooka; Gotaro Shirakami; Takeshi Usui; Akira Shimatsu; K Doi; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa; Kazuwa Nakao
Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans.
The Journal of clinical endocrinology and metabolism 2001;86(10):4753-8.
2001: Noritoshi Nagaya; Masaaki Uematsu; Masayasu Kojima; Y Ikeda; F Yoshihara; Wataru Shimizu; Hiroshi Hosoda; Y Hirota; H Ishida; Hidezo Mori; Kenji Kangawa
Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure.
Circulation 2001;104(12):1430-5.
2001: Yuji Hataya; Takashi Akamizu; Kazuhiko Takaya; Naotetsu Kanamoto; Hiroyuki Ariyasu; Misa Saijo; Kenji Moriyama; Akira Shimatsu; Masayasu Kojima; Kenji Kangawa; Kazuwa Nakao
A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans.
The Journal of clinical endocrinology and metabolism 2001;86(9):4552.
2001: Toshio Sekiguchi; Kaoru Miyamoto; Tetsuya Mizutani; Kazuya Yamada; Takashi Yazawa; Miki Yoshino; T Minegishi; Y Takei; Kenji Kangawa; N Minamino; Y Saito; M Kojima
Molecular cloning of natriuretic peptide receptor A from bullfrog (Rana catesbeiana) brain and its functional expression.
Gene 2001;273(2):251-7.
2001: Hiroaki Nishimatsu; Etsu Suzuki; Daisuke Nagata; Nobuo Moriyama; Hiroshi Satonaka; Kenneth Walsh; Masataka Sata; Kenji Kangawa; Hisayuki Matsuo; Atsuo Goto; Tadaichi Kitamura; Yasunobu Hirata
Adrenomedullin induces endothelium-dependent vasorelaxation via the phosphatidylinositol 3-kinase/Akt-dependent pathway in rat aorta.
Circulation research 2001;89(1):63-70.
2001: Takahiro Hayashida; K Murakami; K Mogi; Masugi Nishihara; Masamitsu Nakazato; MS Mondal; Y Horii; Masayasu Kojima; Kenji Kangawa; Noboru Murakami
Ghrelin in domestic animals: distribution in stomach and its possible role.
Domestic animal endocrinology 2001;21(1):17-24.
2001: Masayasu Kojima; Kenji Kangawa
[Ghrelin: a novel growth-hormone releasing peptide].
Nihon rinsho. Japanese journal of clinical medicine 2001;59(7):1400-7.
2001: Toshihiko Ishimitsu; K Hosoya; Kohju Tsukada; Junichi Minami; Y Futoh; Hidehiko Ono; Masami Ohrui; Jun Hino; Kenji Kangawa; Hiroaki Matsuoka
Microsatellite DNA polymorphism of human adrenomedullin gene in normotensive subjects and patients with essential hypertension.
Hypertension 2001;38(1):9-12.
2001: Toshihiro Tsuruda; Johji Kato; Kazuo Kitamura; Kenji Kuwasako; Takuroh Imamura; Yasushi Koiwaya; Kenji Kangawa; Tanenao Eto
Secretion of proadrenomedullin N-terminal 20 peptide from cultured neonatal rat cardiac cells.
Life sciences 2001;69(2):239-45.
2001: A Kubo; Yoshitaka Isumi; Y Ishizaka; Y Tomoda; Kenji Kangawa; Kazuhiro Dohi; Hisayuki Matsuo; Naoto Minamino
C-type natriuretic peptide is synthesized and secreted from leukemia cell lines, peripheral blood cells, and peritoneal macrophages.
Experimental hematology 2001;29(5):609-15.
2001: Noritoshi Nagaya; Masayasu Kojima; Masaaki Uematsu; M Yamagishi; Hiroshi Hosoda; Hideo Oya; Y Hayashi; Kenji Kangawa
Hemodynamic and hormonal effects of human ghrelin in healthy volunteers.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(5):R1483-7.
2001: Toshio Nishikimi; Takeshi Horio; Y Kohmoto; Fumiki Yoshihara; N Nagaya; T Inenaga; M Saito; Megumi Teranishi; M Nakamura; Masami Ohrui; Yuhei Kawano; Hisayuki Matsuo; Toshihiko Ishimitsu; S Takishita; Hiroaki Matsuoka; Kenji Kangawa
Molecular forms of plasma and urinary adrenomedullin in normal, essential hypertension and chronic renal failure.
Journal of hypertension 2001;19(4):765-73.
2001: Toshihiro Tsuruda; Johji Kato; Kazuo Kitamura; Kazuya Mishima; Takuroh Imamura; Yasushi Koiwaya; Kenji Kangawa; Tanenao Eto
Roles of protein kinase C and Ca2+-dependent signaling in angiotensin II-induced adrenomedullin production in rat cardiac myocytes.
Journal of hypertension 2001;19(4):757-63.
2001: Koji Toshinai; Muhtashan S Mondal; Masamitsu Nakazato; Yukari Date; Noboru Murakami; M Kojima; Kenji Kangawa; Shigeru Matsukura
Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration.
Biochemical and biophysical research communications 2001;281(5):1220-5.
2001: Y Tomoda; Katsuro Kikumoto; Yoshitaka Isumi; Takeshi Katafuchi; A Tanaka; Kenji Kangawa; Kazuhiro Dohi; Naoto Minamino
Cardiac fibroblasts are major production and target cells of adrenomedullin in the heart in vitro.
Cardiovascular research 2001;49(4):721-30.
2001: Mitsuyo Shintani; Yoshihiro Ogawa; Ken Ebihara; Megumi Aizawa-Abe; Fumiko Miyanaga; Kazuhiko Takaya; Takeshi Hayashi; Gen Inoue; Kiminori Hosoda; Masayasu Kojima; Kenji Kangawa; Kazuwa Nakao
Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway.
Diabetes 2001;50(2):227-32.
2001: Noritoshi Nagaya; T Nishikimi; Masaaki Uematsu; T Satoh; Shingo Kyotani; Fumio Sakamaki; M Kakishita; K Fukushima; Y Okano; Norifumi Nakanishi; Kunio Miyatake; Kenji Kangawa
[Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension].
Journal of cardiology 2001;37(2):110-1.
2001: Fumiki Yoshihara; Toshio Nishikimi; Ichiro Okano; Takeshi Horio; Chikao Yutani; Hisayuki Matsuo; S Takishita; T Ohe; Kenji Kangawa
Alterations of intrarenal adrenomedullin and its receptor system in heart failure rats.
Hypertension 2001;37(2):216-22.
2001: Yukari Date; Masamitsu Nakazato; Noboru Murakami; M Kojima; Kenji Kangawa; Shigeru Matsukura
Ghrelin acts in the central nervous system to stimulate gastric acid secretion.
Biochemical and biophysical research communications 2001;280(3):904-7.
2001: Masamitsu Nakazato; Noboru Murakami; Yukari Date; M Kojima; H Matsuo; Kenji Kangawa; Shigeru Matsukura
A role for ghrelin in the central regulation of feeding.
Nature 2001;409(6817):194-8.
2001: Masayasu Kojima; Hiroshi Hosoda; Kenji Kangawa
Purification and distribution of ghrelin: the natural endogenous ligand for the growth hormone secretagogue receptor.
Hormone research 2001;56 Suppl 1():93-7.
2001: S Sugo; Naoto Minamino; H Shoji; Yoshitaka Isumi; K Nakao; Kenji Kangawa; Hisayuki Matsuo
Regulation of endothelin-1 production in cultured rat vascular smooth muscle cells.
Journal of cardiovascular pharmacology 2001;37(1):25-40.
2001: Hiroshi Asakawa; Toshio Nishikimi; T Suzuki; S Hara; Yusuke Tsubokou; Hiroshi Yagi; Akihisa Yabe; N Tsuchiya; Shigeo Horinaka; Kenji Kangawa; Hiroaki Matsuoka
Elevation of two molecular forms of adrenomedullin in plasma and urine in patients with acute myocardial infarction treated with early coronary angioplasty.
Clinical science (London, England : 1979) 2001;100(1):117-26.
2001: Toshio Nishikimi; S Nagata; T Sasaki; Fumiki Yoshihara; Noritoshi Nagaya; Takeshi Horio; H Matsuo; H Matsuoka; Kenji Kangawa
The active molecular form of plasma adrenomedullin is extracted in the pulmonary circulation in patients with mitral stenosis: possible role of adrenomedullin in pulmonary hypertension.
Clinical science (London, England : 1979) 2001;100(1):61-6.
2000: Hiroshi Hosoda; Masayasu Kojima; Hisayuki Matsuo; Kenji Kangawa
Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue.
Biochemical and biophysical research communications 2000;279(3):909-13.
2000: Kazuhiro J Mori; Akihiro Yoshimoto; Kazuhiko Takaya; Kiminori Hosoda; Hiroyuki Ariyasu; Kensei Yahata; Masashi Mukoyama; Akira Sugawara; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa; Kazuwa Nakao
Kidney produces a novel acylated peptide, ghrelin.
FEBS letters 2000;486(3):213-6.
2000: Kazuhiko Takaya; Hiroyuki Ariyasu; Naotetsu Kanamoto; Hiroshi Iwakura; Akihiro Yoshimoto; M Harada; Kazuhiro J Mori; Yasato Komatsu; Takeshi Usui; Akira Shimatsu; Yoshihiro Ogawa; Kiminori Hosoda; Takashi Akamizu; Masayasu Kojima; Kenji Kangawa; Kazuwa Nakao
Ghrelin strongly stimulates growth hormone release in humans.
The Journal of clinical endocrinology and metabolism 2000;85(12):4908-11.
2000: Toshio Nishikimi; A Miyata; Takeshi Horio; Fumiki Yoshihara; N Nagaya; S Takishita; Chikao Yutani; Hisayuki Matsuo; H Matsuoka; Kenji Kangawa
Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart.
American journal of physiology. Heart and circulatory physiology 2000;279(6):H3031-9.
2000: Noritoshi Nagaya; T Nishikimi; Masaaki Uematsu; T Satoh; Hideo Oya; Shingo Kyotani; Fumio Sakamaki; K Ueno; Norifumi Nakanishi; Kunio Miyatake; Kenji Kangawa
Haemodynamic and hormonal effects of adrenomedullin in patients with pulmonary hypertension.
Heart (British Cardiac Society) 2000;84(6):653-8.
2000: Yukari Date; M Kojima; Hiroshi Hosoda; A Sawaguchi; Muhtashan S Mondal; T Suganuma; Shigeru Matsukura; Kenji Kangawa; Masamitsu Nakazato
Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.
Endocrinology 2000;141(11):4255-61.
2000: T Maki; Takeshi Horio; Fumiki Yoshihara; Shin-ichi Suga; S Takeo; H Matsuo; Kenji Kangawa
Effect of neutral endopeptidase inhibitor on endogenous atrial natriuretic peptide as a paracrine factor in cultured cardiac fibroblasts.
British journal of pharmacology 2000;131(6):1204-10.
2000: Masamitsu Nakazato; R Hanada; Noboru Murakami; Yukari Date; Muhtashan S Mondal; M Kojima; H Yoshimatsu; Kenji Kangawa; Shigeru Matsukura
Central effects of neuromedin U in the regulation of energy homeostasis.
Biochemical and biophysical research communications 2000;277(1):191-4.
2000: Masayasu Kojima; R Haruno; M Nakazato; Y Date; N Murakami; R Hanada; Hisayuki Matsuo; Kenji Kangawa
Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3).
Biochemical and biophysical research communications 2000;276(2):435-8.
2000: Toshio Nishikimi; Hiroaki Matsuoka; K Shimada; Hisayuki Matsuo; Kenji Kangawa
Production and clearance sites of two molecular forms of adrenomedullin in human plasma.
American journal of hypertension 2000;13(9):1032-4.
2000: Yukari Date; Noboru Murakami; M Kojima; T Kuroiwa; Shigeru Matsukura; Kenji Kangawa; Masamitsu Nakazato
Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats.
Biochemical and biophysical research communications 2000;275(2):477-80.
2000: Noritoshi Nagaya; T Nishikimi; Masaaki Uematsu; T Satoh; Shingo Kyotani; Fumio Sakamaki; M Kakishita; K Fukushima; Y Okano; Norifumi Nakanishi; Kunio Miyatake; Kenji Kangawa
Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension.
Circulation 2000;102(8):865-70.
2000: R Watanabe; Yoshiko Murakami; MD Marmor; Norimitsu Inoue; Yusuke Maeda; Jun Hino; Kenji Kangawa; Michael Julius; Taroh Kinoshita
Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.
The EMBO journal 2000;19(16):4402-11.
2000: Hiroshi Hosoda; Masayasu Kojima; Hisayuki Matsuo; Kenji Kangawa
Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor.
The Journal of biological chemistry 2000;275(29):21995-2000.
2000: Masataka Sata; Masao Kakoki; Daisuke Nagata; Hiroaki Nishimatsu; Etsu Suzuki; T Aoyagi; S Sugiura; H Kojima; Tetsuo Nagano; Kenji Kangawa; Hisayuki Matsuo; Masao Omata; Ryozo Nagai; Yasunobu Hirata
Adrenomedullin and nitric oxide inhibit human endothelial cell apoptosis via a cyclic GMP-independent mechanism.
Hypertension 2000;36(1):83-8.
2000: Koji Abe; Takashi Minegishi; Yoshito Ibuki; M Kojima; Kenji Kangawa
Expression of adrenomedullin in the human corpus luteum.
Fertility and sterility 2000;74(1):141-5.
2000: Atsushi Kubo; Yoshiharu Nishitani; Naoto Minamino; Katsuro Kikumoto; Hideyuki Kurioka; Toshihiko Nishino; Masayuki Iwano; Hideo Shiiki; Kenji Kangawa; Kazuhiro Dohi
Adrenomedullin gene transcription is decreased in peripheral blood mononuclear cells of patients with IgA nephropathy.
Nephron 2000;85(3):201-6.
2000: Toshihiro Tsuruda; Johji Kato; Kazuo Kitamura; Takuroh Imamura; Yasushi Koiwaya; Kenji Kangawa; I Komuro; Y Yazaki; Tanenao Eto
Enhanced adrenomedullin production by mechanical stretching in cultured rat cardiomyocytes.
Hypertension 2000;35(6):1210-4.
2000: Yusuke Maeda; S Tanaka; Jun Hino; Kenji Kangawa; Taroh Kinoshita
Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3.
The EMBO journal 2000;19(11):2475-82.
2000: Takayuki Shindo; Hiroki Kurihara; Koji Maemura; Yukiko Kurihara; Tomoyuki Kuwaki; T Izumida; Naoto Minamino; Kihwan Ju; Hiroyuki Morita; Yoshio Oh-hashi; Mamoru Kumada; Kenji Kangawa; Ryozo Nagai; Yoshio Yazaki
Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature.
Circulation 2000;101(19):2309-16.
2000: Noritoshi Nagaya; Toshio Nishikimi; Fumiki Yoshihara; Takeshi Horio; A Morimoto; Kenji Kangawa
Cardiac adrenomedullin gene expression and peptide accumulation after acute myocardial infarction in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(4):R1019-26.
2000: Yukari Date; Muhtashan S Mondal; S Matsukura; Y Ueta; H Yamashita; H Kaiya; Kenji Kangawa; Masamitsu Nakazato
Distribution of orexin/hypocretin in the rat median eminence and pituitary.
Brain research. Molecular brain research 2000;76(1):1-6.
2000: Yoichi Ueta; Ryota Serino; Izumi Shibuya; Kazuo Kitamura; Kenji Kangawa; J A Russell; Hiroshi Yamashita
A physiological role for adrenomedullin in rats; a potent hypotensive peptide in the hypothalamo-neurohypophysial system.
Experimental physiology 2000;85 Spec No():163S-169S.
2000: Noritoshi Nagaya; Toru Satoh; Toshio Nishikimi; Masaaki Uematsu; Shinichi Furuichi; Fumio Sakamaki; Hideo Oya; Shingo Kyotani; Norifumi Nakanishi; Yoichi Goto; Y Masuda; Kunio Miyatake; Kenji Kangawa
Hemodynamic, renal, and hormonal effects of adrenomedullin infusion in patients with congestive heart failure.
Circulation 2000;101(5):498-503.
2000: Fumiki Yoshihara; Toshio Nishikimi; Takeshi Horio; Chikao Yutani; N Nagaya; Hisayuki Matsuo; T Ohe; Kenji Kangawa
Ventricular adrenomedullin concentration is a sensitive biochemical marker for volume and pressure overload in rats.
American journal of physiology. Heart and circulatory physiology 2000;278(2):H633-42.
2000: Naoto Minamino; Kenji Kangawa; Hisayuki Matsuo
Adrenomedullin: a new peptidergic regulator of the vascular function.
Clinical hemorheology and microcirculation 2000;23(2-4):95-102.
2000: H Sano; A Miyata; K Sato; H Kaiya; Hisayuki Matsuo; Kenji Kangawa
PACAP augments nitric oxide synthesis in rat vascular smooth muscle cells stimulated with IL-1 alpha.
Annals of the New York Academy of Sciences 2000;921():415-9.
2000: A Miyata; H Sano; M Li; Y Matsuda; H Kaiya; K Sato; Hisayuki Matsuo; Kenji Kangawa; A Arimura
Genomic organization and chromosomal localization of the mouse pituitary adenylate cyclase activating polypeptide (PACAP) gene.
Annals of the New York Academy of Sciences 2000;921():344-8.
1999: Yoshitaka Isumi; A Kubo; Takeshi Katafuchi; Kenji Kangawa; Naoto Minamino
Adrenomedullin suppresses interleukin-1beta-induced tumor necrosis factor-alpha production in Swiss 3T3 cells.
FEBS letters 1999;463(1-2):110-4.
1999: Masayasu Kojima; Hiroshi Hosoda; Y Date; M Nakazato; Hisayuki Matsuo; Kenji Kangawa
Ghrelin is a growth-hormone-releasing acylated peptide from stomach.
Nature 1999;402(6762):656-60.
1999: Ikuko Makino; Kazuhiko Shibata; Yasuo Makino; Kenji Kangawa; Tatsuhiko Kawarabayashi
Potentiation of the hypotensive effect of adrenomedullin in pregnant rats.
European journal of pharmacology 1999;385(2-3):129-36.
1999: Ikuko Makino; Yasuo Makino; Kenji Kangawa; Kazuhiko Shibata
Attenuated hypotensive response to proadrenomedullin N-terminal 20 peptide in pregnant rats: modulation by steroid hormones.
Peptides 1999;20(12):1521-5.
1999: Yasuo Makino; Kazuhiko Shibata; Ikuko Makino; Y Ono; Kenji Kangawa; Tatsuhiko Kawarabayashi
Expression of adrenomedullin in feto-placental circulation of human normotensive pregnant women and pregnancy-induced hypertensive women.
Endocrinology 1999;140(11):5439-42.
1999: Takeshi Horio; T Nishikimi; Fumiki Yoshihara; H Matsuo; S Takishita; Kenji Kangawa
Effects of adrenomedullin on cultured rat cardiac myocytes and fibroblasts.
European journal of pharmacology 1999;382(1):1-9.
1999: Toshihiro Tsuruda; Johji Kato; Kazuo Kitamura; M Kawamoto; Kenji Kuwasako; Takuroh Imamura; Yasushi Koiwaya; T Tsuji; Kenji Kangawa; Tanenao Eto
An autocrine or a paracrine role of adrenomedullin in modulating cardiac fibroblast growth.
Cardiovascular research 1999;43(4):958-67.
1999: Kenji Kuwasako; Kazuo Kitamura; Kenji Kangawa; Yuichiro Ishiyama; Johji Kato; Tanenao Eto
Increased plasma proadrenomedullin N-terminal 20 peptide in patients with essential hypertension.
Annals of clinical biochemistry 1999;36 ( Pt 5)():622-8.
1999: Takashi Minegishi; M Nakamura; Koji Abe; M Tano; A Andoh; M Yoshida; T Takagi; T Nishikimi; M Kojima; Kenji Kangawa
Adrenomedullin and atrial natriuretic peptide concentrations in normal pregnancy and pre-eclampsia.
Molecular human reproduction 1999;5(8):767-70.
1999: M Yoshibayashi; T Kamiya; Toshio Nishikimi; Y Saito; H Matsuo; Kenji Kangawa
Elevated plasma levels of adrenomedullin in congenital cyanotic heart disease.
Clinical science (London, England : 1979) 1999;96(6):543-7.
1999: A Morimoto; T Nishikimi; Fumiki Yoshihara; Takeshi Horio; Noritoshi Nagaya; H Matsuo; K Dohi; Kenji Kangawa
Ventricular adrenomedullin levels correlate with the extent of cardiac hypertrophy in rats.
Hypertension 1999;33(5):1146-52.
1999: S Inoue; Y Hayashi; Yoshihiko Ohnishi; Katsuro Kikumoto; Naoto Minamino; Kenji Kangawa; Hisayuki Matsuo; H Furuya; Masakazu Kuro
Cerebral production of adrenomedullin afer hypothermic cardiopulmonary bypass in adult cardiac surgical patients.
Anesthesia and analgesia 1999;88(5):1030-5.
1999: Yukari Date; Masamitsu Nakazato; Hideki Yamaguchi; Kenji Kangawa; Y Kinoshita; T Chiba; Y Ueta; H Yamashita; Shigeru Matsukura
Enterochromaffin-like cells, a cellular source of uroguanylin in rat stomach.
Endocrinology 1999;140(5):2398-404.
1999: Ryota Serino; Yoichi Ueta; Y Hara; Masayoshi Nomura; Yukiyo Yamamoto; Izumi Shibuya; Y Hattori; Kazuo Kitamura; Kenji Kangawa; J A Russell; Hiroshi Yamashita
Centrally administered adrenomedullin increases plasma oxytocin level with induction of c-fos messenger ribonucleic acid in the paraventricular and supraoptic nuclei of the rat.
Endocrinology 1999;140(5):2334-42.
1999: Noritoshi Nagaya; Toshio Nishikimi; Masaaki Uematsu; Yuji Yoshitomi; Y Miyao; Shunichi Miyazaki; Yoichi Goto; Sunao Kojima; Morio Kuramochi; H Matsuo; Kenji Kangawa; Hiroshi Nonogi
Plasma adrenomedullin as an indicator of prognosis after acute myocardial infarction.
Heart (British Cardiac Society) 1999;81(5):483-7.
1999: Ikuko Makino; Kazuhiko Shibata; Yasuo Makino; Kenji Kangawa; Tatsuhiko Kawarabayashi
Adrenomedullin attenuates the hypertension in hypertensive pregnant rats induced by N(G)-nitro-L-arginine methyl ester.
European journal of pharmacology 1999;371(2-3):159-67.
1999: Daisuke Nagata; Yasunobu Hirata; Etsu Suzuki; Masao Kakoki; Hiroshi Hayakawa; Atsuo Goto; T Ishimitsu; Naoto Minamino; Y Ono; Kenji Kangawa; Hisayuki Matsuo; Masao Omata
Hypoxia-induced adrenomedullin production in the kidney.
Kidney international 1999;55(4):1259-67.
1999: Yoshiharu Nishitani; Atsushi Kubo; Y Kaneko; Y Ono; Hideyuki Kurioka; K Kurooka; N Minamino; Kenji Kangawa; K Okada; H Nonaka; Kazuhiro Dohi
Increased urinary levels of adrenomedullin in patients with cystitis.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1999;33(4):772-7.
1999: K Fujimoto; K Ohta; Kenji Kangawa; U Kikkawa; S Ogino; H Fukui
Identification of protein kinase C phosphorylation sites involved in phorbol ester-induced desensitization of the histamine H1 receptor.
Molecular pharmacology 1999;55(4):735-42.
1999: Jun Hino; Hisayuki Matsuo; Kenji Kangawa
Bone morphogenetic protein-3b (BMP-3b) gene expression is correlated with differentiation in rat calvarial osteoblasts.
Biochemical and biophysical research communications 1999;256(2):419-24.
1999: Y Hayashi; Naoto Minamino; Yoshitaka Isumi; Kenji Kangawa; Masakazu Kuro; Hisayuki Matsuo
Effects of thiopental, ketamine, etomidate, propofol and midazolam on the production of adrenomedullin and endothelin-1 in vascular smooth muscle cells.
Research communications in molecular pathology and pharmacology 1999;103(3):325-31.
1999: Johji Kato; Kazuo Kitamura; Eizaburo Matsui; M Tanaka; Y Ishizaka; Toshihiro Kita; Kenji Kangawa; Tanenao Eto
Plasma adrenomedullin and natriuretic peptides in patients with essential or malignant hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 1999;22(1):61-5.
1999: N Hirayama; Kazuo Kitamura; Takuroh Imamura; Johji Kato; Yasushi Koiwaya; T Tsuji; Kenji Kangawa; Tanenao Eto
Molecular forms of circulating adrenomedullin in patients with congestive heart failure.
The Journal of endocrinology 1999;160(2):297-303.
1999: Noritoshi Nagaya; Yoichi Goto; T Nishikimi; Masaaki Uematsu; Y Miyao; Y Kobayashi; Shunichi Miyazaki; S Hamada; S Kuribayashi; M Takamiya; H Matsuo; Kenji Kangawa; Hiroshi Nonogi
Sustained elevation of plasma brain natriuretic peptide levels associated with progressive ventricular remodelling after acute myocardial infarction.
Clinical science (London, England : 1979) 1999;96(2):129-36.
1999: Yukari Date; Y Ueta; H Yamashita; H Yamaguchi; Shigeru Matsukura; Kenji Kangawa; T Sakurai; M Yanagisawa; Masamitsu Nakazato
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):748-53.
1999: Yoichi Ueta; Y Hara; VS Setiadji; Toyohi Isse; Izumi Shibuya; Kazuo Kitamura; Kenji Kangawa; H Matsuo; Tanenao Eto; Y Hattori; Hiroshi Yamashita
Adrenomedullin-like immunoreactivity in the rat hypothalamo-neurohypophysial tract.
Peptides 1999;20(2):199-204.
1999: M Michishita; Takashi Minegishi; Koji Abe; Kenji Kangawa; M Kojima; Yoshito Ibuki
Expression of adrenomedullin in the endometrium of the human uterus.
Obstetrics and gynecology 1999;93(1):66-70.
1999: Noritoshi Nagaya; Toshio Nishikimi; T Horio; F Yoshihara; A Kanazawa; H Matsuo; Kenji Kangawa
Cardiovascular and renal effects of adrenomedullin in rats with heart failure.
The American journal of physiology 1999;276(1 Pt 2):R213-8.
1999: M Kakishita; T Nishikimi; Y Okano; T Satoh; Shingo Kyotani; Noritoshi Nagaya; K Fukushima; Norifumi Nakanishi; S Takishita; A Miyata; Kenji Kangawa; H Matsuo; T Kunieda
Increased plasma levels of adrenomedullin in patients with pulmonary hypertension.
Clinical science (London, England : 1979) 1999;96(1):33-9.
1998: A Miyata; K Sato; Jun Hino; H Tamakawa; Hisayuki Matsuo; Kenji Kangawa
Rat aortic smooth-muscle cell proliferation is bidirectionally regulated in a cell cycle-dependent manner via PACAP/VIP type 2 receptor.
Annals of the New York Academy of Sciences 1998;865():73-81.
1998: Jun-Ichiro Sakata; Yujiro Asada; T Shimokubo; Michitaka Kitani; Haruhiko Inatsu; Kazuo Kitamura; Kenji Kangawa; H Matsuo; Akinobu Sumiyoshi; Tanenao Eto
Adrenomedullin in the gastrointestinal tract. Distribution and gene expression in rat and augmented gastric adrenomedullin after fasting.
Journal of gastroenterology 1998;33(6):828-34.
1998: Koji Abe; Takashi Minegishi; M Tano; Toshio Hirakawa; Megumi Tsuchiya; Kenji Kangawa; M Kojima; Yoshito Ibuki
Expression and effect of adrenomedullin on rat granulosa cell.
Endocrinology 1998;139(12):5263-6.
1998: Masamitsu Nakazato; Hideki Yamaguchi; Yukari Date; Mikiya Miyazato; Kenji Kangawa; Michael F Goy; N Chino; Shigeru Matsukura
Tissue distribution, cellular source, and structural analysis of rat immunoreactive uroguanylin.
Endocrinology 1998;139(12):5247-54.
1998: Takeshi Horio; Toshio Nishikimi; Fumiki Yoshihara; Noritoshi Nagaya; H Matsuo; S Takishita; Kenji Kangawa
Production and secretion of adrenomedullin in cultured rat cardiac myocytes and nonmyocytes: stimulation by interleukin-1beta and tumor necrosis factor-alpha.
Endocrinology 1998;139(11):4576-80.
1998: K Fujimoto; K Ohta; Kenji Kangawa; U Kikkawa; S Ogino; H Fukui
[Identification of protein kinase C phosphorylation sites involved in desensitization of the histamine H1 receptor].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1998;112 Suppl 1():143P-147P.
1998: Y Ono; M Kojima; K Okada; Kenji Kangawa
cDNA cloning of canine adrenomedullin and its gene expression in the heart and blood vessels in endotoxin shock.
Shock (Augusta, Ga.) 1998;10(4):243-7.
1998: Katsuro Kikumoto; Atsushi Kubo; Y Hayashi; Naoto Minamino; S Inoue; Kazuhiro Dohi; K Kitamura; Kenji Kangawa; Hisayuki Matsuo; H Furuya
Increased plasma concentration of adrenomedullin in patients with subarachnoid hemorrhage.
Anesthesia and analgesia 1998;87(4):859-63.
1998: Atsushi Kubo; Hideyuki Kurioka; Naoto Minamino; Yoshiharu Nishitani; Hiroaki Sato; Toshihiko Nishino; Masayuki Iwano; Hideo Shiiki; Kenji Kangawa; H Matsuo; Kazuhiro Dohi
Plasma and urinary levels of adrenomedullin in chronic glomerulonephritis patients with proteinuria.
Nephron 1998;80(2):227-30.
1998: N Shinoki; Tomio Kawasaki; Naoto Minamino; K Okahara; A Ogawa; Hideo Ariyoshi; Masato Sakon; Junichi Kambayashi; Kenji Kangawa; Morito Monden
Shear stress down-regulates gene transcription and production of adrenomedullin in human aortic endothelial cells.
Journal of cellular biochemistry 1998;71(1):109-15.
1998: Fumiki Yoshihara; Toshio Nishikimi; Takeshi Horio; Chikao Yutani; S Takishita; Hisayuki Matsuo; T Ohe; Kenji Kangawa
Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline.
European journal of pharmacology 1998;355(1):33-9.
1998: M Nishi; Shinji Komazaki; Masamitsu Iino; Kenji Kangawa; Hiroshi Takeshima
Mitsugumin23, a novel transmembrane protein on endoplasmic reticulum and nuclear membranes.
FEBS letters 1998;432(3):191-6.
1998: T Nishikimi; Takeshi Horio; Fumiki Yoshihara; Noritoshi Nagaya; H Matsuo; Kenji Kangawa
Effect of adrenomedullin on cAMP and cGMP levels in rat cardiac myocytes and nonmyocytes.
European journal of pharmacology 1998;353(2-3):337-44.
1998: A Kubo; Naoto Minamino; Yoshitaka Isumi; Takeshi Katafuchi; Kenji Kangawa; Kazuhiro Dohi; Hisayuki Matsuo
Production of adrenomedullin in macrophage cell line and peritoneal macrophage.
The Journal of biological chemistry 1998;273(27):16730-8.
1998: N Yang; O Higuchi; K Ohashi; K Nagata; A Wada; Kenji Kangawa; E Nishida; K Mizuno
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization.
Nature 1998;393(6687):809-12.
1998: H Yamaguchi; Masamitsu Nakazato; M Miyazato; H Toshimori; S Oki; K Shimizu; M Suiko; Kenji Kangawa; S Matsukura
Identification of a novel splicing mutation and 1-bp deletion in the 17alpha-hydroxylase gene of Japanese patients with 17alpha-hydroxylase deficiency.
Human genetics 1998;102(6):635-9.
1998: Yoshitaka Isumi; Naoto Minamino; Takeshi Katafuchi; M Yoshioka; T Tsuji; Kenji Kangawa; Hisayuki Matsuo
Adrenomedullin production in fibroblasts: its possible function as a growth regulator of Swiss 3T3 cells.
Endocrinology 1998;139(5):2552-63.
1998: A Kubo; Naoto Minamino; Yoshitaka Isumi; Kenji Kangawa; Kazuhiro Dohi; Hisayuki Matsuo
Adrenomedullin production is correlated with differentiation in human leukemia cell lines and peripheral blood monocytes.
FEBS letters 1998;426(2):233-7.
1998: Kazuo Kitamura; Johji Kato; M Kawamoto; M Tanaka; N Chino; Kenji Kangawa; Tanenao Eto
The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma.
Biochemical and biophysical research communications 1998;244(2):551-5.
1998: Yoshitaka Isumi; Naoto Minamino; A Kubo; N Nishimoto; K Yoshizaki; M Yoshioka; Kenji Kangawa; Hisayuki Matsuo
Adrenomedullin stimulates interleukin-6 production in Swiss 3T3 cells.
Biochemical and biophysical research communications 1998;244(2):325-31.
1998: Yoshitaka Isumi; H Shoji; S Sugo; T Tochimoto; M Yoshioka; Kenji Kangawa; Hisayuki Matsuo; Naoto Minamino
Regulation of adrenomedullin production in rat endothelial cells.
Endocrinology 1998;139(3):838-46.
1998: H Tamakawa; A Miyata; K Satoh; Y Miyake; Hisayuki Matsuo; A Arimura; Kenji Kangawa
The augmentation of pituitary adenylate cyclase-activating polypeptide (PACAP) in streptozotocin-induced diabetic rats.
Peptides 1998;19(9):1497-502.
1998: Atsushi Kubo; Masayuki Iwano; Naoto Minamino; H Sato; Toshihiko Nishino; E Hirata; Yasuhiro Akai; Hideo Shiiki; K Kitamura; Kenji Kangawa; H Matsuo; Kazuhiro Dohi
Measurement of plasma and urinary adrenomedullin in patients with IgA nephropathy.
Nephron 1998;78(4):389-94.
1998: Y Miyao; Toshio Nishikimi; Yoichi Goto; Shunichi Miyazaki; Satoshi Daikoku; Isao Morii; T Matsumoto; S Takishita; A Miyata; H Matsuo; Kenji Kangawa; Hiroshi Nonogi
Increased plasma adrenomedullin levels in patients with acute myocardial infarction in proportion to the clinical severity.
Heart (British Cardiac Society) 1998;79(1):39-44.
1998: Noritoshi Nagaya; Toshio Nishikimi; Yoichi Goto; Y Miyao; Y Kobayashi; Isao Morii; Satoshi Daikoku; T Matsumoto; Shunichi Miyazaki; H Matsuoka; S Takishita; Kenji Kangawa; H Matsuo; Hiroshi Nonogi
Plasma brain natriuretic peptide is a biochemical marker for the prediction of progressive ventricular remodeling after acute myocardial infarction.
American heart journal 1998;135(1):21-8.
1998: Toshihiro Tsuruda; Johji Kato; Kazuo Kitamura; Kenji Kuwasako; Takuroh Imamura; Yasushi Koiwaya; T Tsuji; Kenji Kangawa; Tanenao Eto
Adrenomedullin: a possible autocrine or paracrine inhibitor of hypertrophy of cardiomyocytes.
Hypertension 1998;31(1 Pt 2):505-10.
1998: Noritoshi Nagaya; T Nishikimi; Y Okano; Masaaki Uematsu; T Satoh; Shingo Kyotani; S Kuribayashi; S Hamada; M Kakishita; Norifumi Nakanishi; M Takamiya; T Kunieda; H Matsuo; Kenji Kangawa
Plasma brain natriuretic peptide levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension.
Journal of the American College of Cardiology 1998;31(1):202-8.
1997: Toshio Nishikimi; Takeshi Horio; T Sasaki; Fumiki Yoshihara; S Takishita; A Miyata; Hisayuki Matsuo; Kenji Kangawa
Cardiac production and secretion of adrenomedullin are increased in heart failure.
Hypertension 1997;30(6):1369-75.
1997: Hikaru Ueno; Atsushi Haruno; Nobuhiro Morisaki; M Furuya; Kenji Kangawa; Akira Takeshita; Yasushi Saito
Local expression of C-type natriuretic peptide markedly suppresses neointimal formation in rat injured arteries through an autocrine/paracrine loop.
Circulation 1997;96(7):2272-9.
1997: Toshio Nishikimi; S Nagata; T Sasaki; S Tomimoto; H Matsuoka; S Takishita; K Kitamura; A Miyata; H Matsuo; Kenji Kangawa
Plasma concentrations of adrenomedullin correlate with the extent of pulmonary hypertension in patients with mitral stenosis.
Heart (British Cardiac Society) 1997;78(4):390-5.
1997: Y Date; Masamitsu Nakazato; Kenji Kangawa; K Shirieda; T Fujimoto; S Matsukura
Detection of three transthyretin gene mutations in familial amyloidotic polyneuropathy by analysis of DNA extracted from formalin-fixed and paraffin-embedded tissues.
Journal of the neurological sciences 1997;150(2):143-8.
1997: Kenji Kuwasako; Kazuo Kitamura; Yuichiro Ishiyama; H Washimine; Johji Kato; Kenji Kangawa; Tanenao Eto
Purification and characterization of PAMP-12 (PAMP[9-20]) in porcine adrenal medulla as a major endogenous biologically active peptide.
FEBS letters 1997;414(1):105-10.
1997: A I Khan; Johji Kato; Yuichiro Ishiyama; Kazuo Kitamura; Kenji Kangawa; Tanenao Eto
Effect of chronically infused adrenomedullin in two-kidney, one-clip hypertensive rats.
European journal of pharmacology 1997;333(2-3):187-90.
1997: M Miyazato; M Nakazato; S Matsukura; Kenji Kangawa; Hisayuki Matsuo
Genomic structure and chromosomal localization of human uroguanylin.
Genomics 1997;43(3):359-65.
1997: S Yamamoto; Isao Morimoto; Nobuyuki Yanagihara; Kenji Kangawa; Kiyotoshi Inenaga; Sumiya Eto; Hiroshi Yamashita
C-type natriuretic peptide suppresses arginine-vasopressin secretion from dissociated magnocellular neurons in newborn rat supraoptic nucleus.
Neuroscience letters 1997;229(2):97-100.
1997: Yuichiro Ishiyama; Kazuo Kitamura; Johji Kato; Jun-Ichiro Sakata; Kenji Kangawa; Tanenao Eto
Changes in cardiac adrenomedullin concentration in renovascular hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 1997;20(2):113-7.
1997: Mikiyasu Shirai; Akito Shimouchi; S Ikeda; Ishio Ninomiya; K Sunagawa; Kenji Kangawa; H Matsuo
Vasodilator effects of adrenomedullin on small pulmonary arteries and veins in anaesthetized cats.
British journal of pharmacology 1997;121(4):679-86.
1997: M Yoshibayashi; T Kamiya; K Kitamura; Y Saito; Kenji Kangawa; Toshio Nishikimi; Hiroaki Matsuoka; T Eto; H Matsuo
Plasma levels of adrenomedullin in primary and secondary pulmonary hypertension in patients <20 years of age.
The American journal of cardiology 1997;79(11):1556-8.
1997: H Yamaguchi; Masamitsu Nakazato; M Miyazato; Kenji Kangawa; S Matsukura
A 5'-splice site mutation in the cytochrome P450 steroid 17alpha-hydroxylase gene in 17alpha-hydroxylase deficiency.
The Journal of clinical endocrinology and metabolism 1997;82(6):1934-8.
1997: H Ikenouchi; Kenji Kangawa; Hisayuki Matsuo; Yasunobu Hirata
Negative inotropic effect of adrenomedullin in isolated adult rabbit cardiac ventricular myocytes.
Circulation 1997;95(9):2318-24.
1997: A I Khan; Johji Kato; Kazuo Kitamura; Kenji Kangawa; Tanenao Eto
Hypotensive effect of chronically infused adrenomedullin in conscious Wistar-Kyoto and spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology 1997;24(2):139-42.
1997: T Ishihara; Johji Kato; Kazuo Kitamura; F Katoh; Shouichi Fujimoto; Kenji Kangawa; Tanenao Eto
Production of adrenomedullin in human vascular endothelial cells.
Life sciences 1997;60(20):1763-9.
1997: T Etoh; Johji Kato; H Washimine; Takuroh Imamura; Kazuo Kitamura; Yasushi Koiwaya; Kenji Kangawa; Tanenao Eto
Plasma proadrenomedullin N-terminal 20 peptide (PAMP) in patients with congestive heart failure.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1997;29(1):46-7.
1996: M Miyazato; M Nakazato; S Matsukura; Kenji Kangawa; Hisayuki Matsuo
Uroguanylin gene expression in the alimentary tract and extra-gastrointestinal tissues.
FEBS letters 1996;398(2-3):170-4.
1996: Kenji Kangawa; K Kitamura; Naoto Minamino; T Eto; Hisayuki Matsuo
Adrenomedullin: a new hypotensive peptide.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1996;14(5):S105-10.
1996: M Tanaka; Y Ishizaka; Yuichiro Ishiyama; Johji Kato; O Kida; Kazuo Kitamura; Kenji Kangawa; Tanenao Eto
Chronic effect of beta-adrenoceptor blockade on plasma levels of brain natriuretic peptide during exercise in essential hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 1996;19(4):239-45.
1996: Kenji Kangawa; K Kitamura; Naoto Minamino; Hisayuki Matsuo
Adrenomedullin: a new modulator of vascular tone.
Journal of cardiac failure 1996;2(4 Suppl):S135-40.
1996: Akihiko Osajima; Yasuhito Uezono; M Tamura; Kazuo Kitamura; Y Mutoh; Yoichi Ueta; Kenji Kangawa; M Kawamura; T Eto; H Yamashita; Futoshi Izumi; M Takasugi; A Kuroiwa
Adrenomedullin-sensitive receptors are preferentially expressed in cultured rat mesangial cells.
European journal of pharmacology 1996;315(3):319-25.
1996: T Shimokubo; Jun-Ichiro Sakata; Kazuo Kitamura; Kenji Kangawa; H Matsuo; Tanenao Eto
Adrenomedullin: changes in circulating and cardiac tissue concentration in Dahl salt-sensitive rats on a high-salt diet.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1996;18(7):949-61.
1996: T Ishimitsu; T Nishikimi; H Matsuoka; Kenji Kangawa; K Kitamura; J Minami; H Matsuo; T Eto
Behaviour of adrenomedullin during acute and chronic salt loading in normotensive and hypertensive subjects.
Clinical science (London, England : 1979) 1996;91(3):293-8.
1996: T Nishikimi; Fumiki Yoshihara; A Morimoto; K Ishikawa; T Ishimitsu; Y Saito; Kenji Kangawa; H Matsuo; T Omae; H Matsuoka
Relationship between left ventricular geometry and natriuretic peptide levels in essential hypertension.
Hypertension 1996;28(1):22-30.
1996: Y Nagatomo; Kazuo Kitamura; Kenji Kangawa; Y Fujimoto; Tanenao Eto
Proadrenomedullin N-terminal 20 peptide is rapidly cleaved by neutral endopeptidase.
Biochemical and biophysical research communications 1996;223(3):539-43.
1996: J Hino; M Takao; N Takeshita; Y Konno; T Nishizawa; Hisayuki Matsuo; Kenji Kangawa
cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b).
Biochemical and biophysical research communications 1996;223(2):304-10.
1996: T Nishikimi; H Matsuoka; K Ishikawa; Fumiki Yoshihara; Yuhei Kawano; K Kitamura; Y Saito; Kenji Kangawa; H Matsuo; T Omae
Antihypertensive therapy reduces increased plasma levels of adrenomedullin and brain natriuretic peptide concomitant with regression of left ventricular hypertrophy in a patient with malignant hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 1996;19(2):97-101.
1996: Masamitsu Nakazato; Hideki Yamaguchi; H Kinoshita; Kenji Kangawa; H Matsuo; N Chino; S Matsukura
Identification of biologically active and inactive human uroguanylins in plasma and urine and their increases in renal insufficiency.
Biochemical and biophysical research communications 1996;220(3):586-93.
1996: M Takao; J Hino; N Takeshita; Y Konno; T Nishizawa; Hisayuki Matsuo; Kenji Kangawa
Identification of rat bone morphogenetic protein-3b (BMP-3b), a new member of BMP-3.
Biochemical and biophysical research communications 1996;219(2):656-62.
1996: M Miyazato; Masamitsu Nakazato; Hideki Yamaguchi; Yukari Date; M Kojima; Kenji Kangawa; H Matsuo; S Matsukura
Cloning and characterization of a cDNA encoding a precursor for human uroguanylin.
Biochemical and biophysical research communications 1996;219(2):644-8.
1996: H Inatsu; Jun-Ichiro Sakata; T Shimokubo; Michitaka Kitani; M Nishizono; H Washimine; Kazuo Kitamura; Kenji Kangawa; H Matsuo; Tanenao Eto
Distribution and characterization of rat immunoreactive proadrenomedullin N-terminal 20 peptide (PAMP) and the augmented cardiac PAMP in spontaneously hypertensive rat.
Biochemistry and molecular biology international 1996;38(2):365-72.
1996: Y Makino; Naoto Minamino; E Kakishita; Kenji Kangawa; Hisayuki Matsuo
Natriuretic peptides in water-deprived and in salt-loaded rats.
Peptides 1996;17(6):1031-9.
1996: Johji Kato; K Kobayashi; T Etoh; M Tanaka; Kazuo Kitamura; Takuroh Imamura; Yasushi Koiwaya; Kenji Kangawa; Tanenao Eto
Plasma adrenomedullin concentration in patients with heart failure.
The Journal of clinical endocrinology and metabolism 1996;81(1):180-3.
1995: Yoichi Ueta; Kazuo Kitamura; Toyohi Isse; Izumi Shibuya; Narutoshi Kabashima; S Yamamoto; Kenji Kangawa; H Matsuo; T Eto; H Yamashita
Adrenomedullin-immunoreactive neurons in the paraventricular and supraoptic nuclei of the rat.
Neuroscience letters 1995;202(1-2):37-40.
1995: H Washimine; Y Yamamoto; Kazuo Kitamura; M Tanaka; Y Ichiki; Kenji Kangawa; H Matsuo; Tanenao Eto
Plasma concentration of human adrenomedullin in patients on hemodialysis.
Clinical nephrology 1995;44(6):389-93.
1995: T Nishikimi; Y Saito; K Kitamura; T Ishimitsu; T Eto; Kenji Kangawa; H Matsuo; T Omae; H Matsuoka
Increased plasma levels of adrenomedullin in patients with heart failure.
Journal of the American College of Cardiology 1995;26(6):1424-31.
1995: H Shoji; Naoto Minamino; Kenji Kangawa; Hisayuki Matsuo
Endotoxin markedly elevates plasma concentration and gene transcription of adrenomedullin in rat.
Biochemical and biophysical research communications 1995;215(2):531-7.
1995: K Kato; Kazuo Kitamura; Kenji Kuwasako; M Tanaka; Yuichiro Ishiyama; T Shimokubo; Y Ichiki; S Nakamura; Kenji Kangawa; Tanenao Eto
Plasma adrenomedullin in patients with primary aldosteronism.
American journal of hypertension 1995;8(10 Pt 1):997-1000.
1995: Y Ichiki; Kazuo Kitamura; Kenji Kangawa; M Kawamoto; H Matsuo; Tanenao Eto
Distribution and characterization of immunoreactive adrenomedullin in porcine tissue, and isolation of adrenomedullin [26-52] and adrenomedullin [34-52] from porcine duodenum.
Journal of biochemistry 1995;118(4):765-70.
1995: Hideki Yamaguchi; Masamitsu Nakazato; M Miyazato; Kenji Kangawa; H Matsuo; S Matsukura
Two novel rat guanylin molecules, guanylin-94 and guanylin-16, do not increase cyclic GMP production in T84 cells.
Biochemical and biophysical research communications 1995;214(3):1204-10.
1995: Yuichiro Ishiyama; Kazuo Kitamura; Y Ichiki; Jun-Ichiro Sakata; O Kida; Kenji Kangawa; Tanenao Eto
Haemodynamic responses to rat adrenomedullin in anaesthetized spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology 1995;22(9):614-8.
1995: Tatsuo Shimosawa; Y Ito; K Ando; Kazuo Kitamura; Kenji Kangawa; Tomoyuki Fujita
Proadrenomedullin NH(2)-terminal 20 peptide, a new product of the adrenomedullin gene, inhibits norepinephrine overflow from nerve endings.
The Journal of clinical investigation 1995;96(3):1672-6.
1995: S Sugo; Naoto Minamino; H Shoji; Kenji Kangawa; Hisayuki Matsuo
Effects of vasoactive substances and cAMP related compounds on adrenomedullin production in cultured vascular smooth muscle cells.
FEBS letters 1995;369(2-3):311-4.
1995: M Tanaka; Kazuo Kitamura; Y Ishizaka; Yuichiro Ishiyama; Johji Kato; Kenji Kangawa; Tanenao Eto
Plasma adrenomedullin in various diseases and exercise-induced change in adrenomedullin in healthy subjects.
Internal medicine (Tokyo, Japan) 1995;34(8):728-33.
1995: Masamitsu Nakazato; K Shiomi; Yukari Date; S Matsukura; Kenji Kangawa; N Minamino; H Matsuo
Isolation and sequence determination of 6- and 8-kDa precursors of human neutrophil peptides from bone marrow, plasma and peripheral blood neutrophils.
Biochemical and biophysical research communications 1995;211(3):1053-62.
1995: Kenji Kuwasako; Kazuo Kitamura; Y Ichiki; Johji Kato; Kenji Kangawa; H Matsuo; Tanenao Eto
Human proadrenomedullin N-terminal 20 peptide in pheochromocytoma and normal adrenal medulla.
Biochemical and biophysical research communications 1995;211(2):694-9.
1995: Naoto Minamino; H Shoji; S Sugo; Kenji Kangawa; Hisayuki Matsuo
Adrenocortical steroids, thyroid hormones and retinoic acid augment the production of adrenomedullin in vascular smooth muscle cells.
Biochemical and biophysical research communications 1995;211(2):686-93.
1995: M Tanaka; Y Ishizaka; Yuichiro Ishiyama; Johji Kato; O Kida; Kazuo Kitamura; Kenji Kangawa; H Matsuo; Tanenao Eto
Exercise-induced secretion of brain natriuretic peptide in essential hypertension and normal subjects.
Hypertension research : official journal of the Japanese Society of Hypertension 1995;18(2):159-66.
1995: Johji Kato; Kazuo Kitamura; Kenji Kangawa; Tanenao Eto
Receptors for adrenomedullin in human vascular endothelial cells.
European journal of pharmacology 1995;289(2):383-5.
1995: Kazuo Kitamura; Kenji Kangawa; H Matsuo; Tanenao Eto
Adrenomedullin. Implications for hypertension research.
Drugs 1995;49(4):485-95.
1995: Yasunobu Hirata; Hiroshi Hayakawa; Y Suzuki; Etsu Suzuki; H Ikenouchi; Osami Kohmoto; K Kimura; Kazuo Kitamura; T Eto; Kenji Kangawa
Mechanisms of adrenomedullin-induced vasodilation in the rat kidney.
Hypertension 1995;25(4 Pt 2):790-5.
1995: H Washimine; Yujiro Asada; Kazuo Kitamura; Y Ichiki; S Hara; Y Yamamoto; Kenji Kangawa; Akinobu Sumiyoshi; Tanenao Eto
Immunohistochemical identification of adrenomedullin in human, rat, and porcine tissue.
Histochemistry and cell biology 1995;103(4):251-4.
1995: Y Ishizaka; Y Yamamoto; M Tanaka; F Kato; Y Ishizaka; N Yokota; Johji Kato; Kazuo Kitamura; Tanenao Eto; Kenji Kangawa
Molecular forms of human brain natriuretic peptide (BNP) in plasma of patients on hemodialysis (HD).
Clinical nephrology 1995;43(4):237-42.
1995: S Sugo; Naoto Minamino; H Shoji; Kenji Kangawa; K Kitamura; T Eto; Hisayuki Matsuo
Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells.
Biochemical and biophysical research communications 1995;207(1):25-32.
1995: F Katoh; Kazuo Kitamura; H Niina; Ryuichi Yamamoto; H Washimine; Kenji Kangawa; Y Yamamoto; Hideyuki Kobayashi; Tanenao Eto; Akihiko Wada
Proadrenomedullin N-terminal 20 peptide (PAMP), an endogenous anticholinergic peptide: its exocytotic secretion and inhibition of catecholamine secretion in adrenal medulla.
Journal of neurochemistry 1995;64(1):459-61.
1995: T Shimokubo; Jun-Ichiro Sakata; Kazuo Kitamura; Kenji Kangawa; H Matsuo; Tanenao Eto
Augmented adrenomedullin concentrations in right ventricle and plasma of experimental pulmonary hypertension.
Life sciences 1995;57(19):1771-9.
1994: Masamitsu Nakazato; Hideki Yamaguchi; K Shiomi; Yukari Date; S Fujimoto; Kenji Kangawa; H Matsuo; S Matsukura
Identification of 10-kDa proguanylin as a major guanylin molecule in human intestine and plasma and its increase in renal insufficiency.
Biochemical and biophysical research communications 1994;205(3):1966-75.
1994: T Ishimitsu; T Nishikimi; Y Saito; K Kitamura; T Eto; Kenji Kangawa; H Matsuo; T Omae; H Matsuoka
Plasma levels of adrenomedullin, a newly identified hypotensive peptide, in patients with hypertension and renal failure.
The Journal of clinical investigation 1994;94(5):2158-61.
1994: T Nishikimi; K Kitamura; Y Saito; K Shimada; T Ishimitsu; M Takamiya; Kenji Kangawa; H Matsuo; T Eto; T Omae
Clinical studies on the sites of production and clearance of circulating adrenomedullin in human subjects.
Hypertension 1994;24(5):600-4.
1994: Jun-Ichiro Sakata; T Shimokubo; Kazuo Kitamura; M Nishizono; Y Iehiki; Kenji Kangawa; H Matsuo; Tanenao Eto
Distribution and characterization of immunoreactive rat adrenomedullin in tissue and plasma.
FEBS letters 1994;352(2):105-8.
1994: S Sugo; Naoto Minamino; H Shoji; Kenji Kangawa; K Kitamura; T Eto; Hisayuki Matsuo
Production and secretion of adrenomedullin from vascular smooth muscle cells: augmented production by tumor necrosis factor-alpha.
Biochemical and biophysical research communications 1994;203(1):719-26.
1994: Kazuo Kitamura; Kenji Kangawa; Yuichiro Ishiyama; H Washimine; Y Ichiki; M Kawamoto; N Minamino; H Matsuo; Tanenao Eto
Identification and hypotensive activity of proadrenomedullin N-terminal 20 peptide (PAMP).
FEBS letters 1994;351(1):35-7.
1994: Yukari Date; Masamitsu Nakazato; K Shiomi; H Toshimori; Kenji Kangawa; H Matsuo; S Matsukura
Localization of human neutrophil peptide (HNP) and its messenger RNA in neutrophil series.
Annals of hematology 1994;69(2):73-7.
1994: H Washimine; Kazuo Kitamura; Y Ichiki; Y Yamamoto; Kenji Kangawa; H Matsuo; Tanenao Eto
Immunoreactive proadrenomedullin N-terminal 20 peptide in human tissue, plasma and urine.
Biochemical and biophysical research communications 1994;202(2):1081-7.
1994: F Katoh; H Niina; Kazuo Kitamura; Y Ichiki; Y Yamamoto; Kenji Kangawa; Tanenao Eto; Akihiko Wada
Ca(2+)-dependent cosecretion of adrenomedullin and catecholamines mediated by nicotinic receptors in bovine cultured adrenal medullary cells.
FEBS letters 1994;348(1):61-4.
1994: S Sugo; Naoto Minamino; Kenji Kangawa; K Miyamoto; K Kitamura; J Sakata; T Eto; Hisayuki Matsuo
Endothelial cells actively synthesize and secrete adrenomedullin.
Biochemical and biophysical research communications 1994;201(3):1160-6.
1994: Y Ishizaka; Y Ishizaka; M Tanaka; Kazuo Kitamura; Kenji Kangawa; N Minamino; H Matsuo; Tanenao Eto
Adrenomedullin stimulates cyclic AMP formation in rat vascular smooth muscle cells.
Biochemical and biophysical research communications 1994;200(1):642-6.
1994: Yasunobu Hirata; Y Suzuki; Etsu Suzuki; Hiroshi Hayakawa; K Kimura; Atsuo Goto; Masao Omata; N Minamino; Kenji Kangawa; Hisayuki Matsuo
Mechanisms underlying the augmented responses of deoxycorticosterone acetate-salt hypertensive rats to neutral endopeptidase inhibitors.
Journal of hypertension 1994;12(4):367-74.
1994: Kazuo Kitamura; Y Ichiki; M Tanaka; M Kawamoto; J Emura; S Sakakibara; Kenji Kangawa; H Matsuo; Tanenao Eto
Immunoreactive adrenomedullin in human plasma.
FEBS letters 1994;341(2-3):288-90.
1994: Kazuo Kitamura; Kenji Kangawa; M Kojima; Y Ichiki; H Matsuo; Tanenao Eto
Complete amino acid sequence of porcine adrenomedullin and cloning of cDNA encoding its precursor.
FEBS letters 1994;338(3):306-10.
1994: Yasunobu Hirata; Etsu Suzuki; Hiroshi Hayakawa; H Matsuoka; T Sugimoto; Kenji Kangawa; Hisayuki Matsuo
Mechanisms of the natriuretic effects of neutral endopeptidase inhibition in Dahl salt-sensitive and salt-resistant rats.
Journal of cardiovascular pharmacology 1994;23(2):283-90.
1994: Y Ichiki; Kazuo Kitamura; Kenji Kangawa; M Kawamoto; H Matsuo; Tanenao Eto
Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma.
FEBS letters 1994;338(1):6-10.
1993: Naoto Minamino; M Aburaya; M Kojima; K Miyamoto; Kenji Kangawa; Hisayuki Matsuo
Distribution of C-type natriuretic peptide and its messenger RNA in rat central nervous system and peripheral tissue.
Biochemical and biophysical research communications 1993;197(1):326-35.
1993: K Shiomi; Masamitsu Nakazato; T Ihi; Kenji Kangawa; H Matsuo; S Matsukura
Establishment of radioimmunoassay for human neutrophil peptides and their increases in plasma and neutrophil in infection.
Biochemical and biophysical research communications 1993;195(3):1336-44.
1993: Jun-Ichiro Sakata; T Shimokubo; Kazuo Kitamura; S Nakamura; Kenji Kangawa; H Matsuo; Tanenao Eto
Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide.
Biochemical and biophysical research communications 1993;195(2):921-7.
1993: Yuichiro Ishiyama; Kazuo Kitamura; Y Ichiki; S Nakamura; O Kida; Kenji Kangawa; Tanenao Eto
Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats.
European journal of pharmacology 1993;241(2-3):271-3.
1993: K Shiomi; Masamitsu Nakazato; S Matsukura; A Ohnishi; H Hatanaka; S Tsuji; Y Murai; M Kojima; Kenji Kangawa; H Matsuo
A basic transthyretin variant (Glu61-->Lys) causes familial amyloidotic polyneuropathy: protein and DNA sequencing and PCR-induced mutation restriction analysis.
Biochemical and biophysical research communications 1993;194(3):1090-6.
1993: Kazuo Kitamura; Jun-Ichiro Sakata; Kenji Kangawa; M Kojima; H Matsuo; Tanenao Eto
Cloning and characterization of cDNA encoding a precursor for human adrenomedullin.
Biochemical and biophysical research communications 1993;194(2):720-5.
1993: N Yokota; Y Yamamoto; Kazuo Kitamura; Kenji Kangawa; N Minamino; H Matsuo; Tanenao Eto
Alterations in circulating and cardiac tissue concentrations of brain natriuretic peptide in spontaneously hypertensive rats.
Cardiovascular research 1993;27(7):1312-5.
1993: Etsu Suzuki; Yasunobu Hirata; Hiroshi Hayakawa; Masao Omata; M Kojima; Kenji Kangawa; N Minamino; Hisayuki Matsuo
Evidence for C-type natriuretic peptide production in the rat kidney.
Biochemical and biophysical research communications 1993;192(2):532-8.
1993: Y Ichiki; Kazuo Kitamura; Kenji Kangawa; Tanenao Eto
Dimeric form of calcitonin gene-related peptide in the porcine thyroid gland.
Biochemical and biophysical research communications 1993;191(3):961-7.
1993: Yasunobu Hirata; H Matsuoka; Etsu Suzuki; Hiroshi Hayakawa; T Sugimoto; Y Matsuda; Y Morishita; Kenji Kangawa; N Minamino; Hisayuki Matsuo
Role of endogenous atrial natriuretic peptide in DOCA-salt hypertensive rats. Effects of a novel nonpeptide antagonist for atrial natriuretic peptide receptor.
Circulation 1993;87(2):554-61.
1993: N Yokota; Y Yamamoto; F Iemura; T Kita; Kenji Kangawa; N Minamino; H Matsuo; Tanenao Eto
Increased plasma levels and effects of brain natriuretic peptide in experimental nephrosis.
Nephron 1993;65(3):454-9.
1993: Y Ohyama; K Miyamoto; Y Morishita; Y Matsuda; M Kojima; Naoto Minamino; Kenji Kangawa; Hisayuki Matsuo
HS-142-1, a novel antagonist for natriuretic peptides, has no effect on the third member of membrane bound guanylate cyclases (GC-C) in T84 cells.
Life sciences 1993;52(17):PL153-7.
1992: Y Ohyama; K Miyamoto; Y Morishita; Y Matsuda; Y Saito; Naoto Minamino; Kenji Kangawa; Hisayuki Matsuo
Stable expression of natriuretic peptide receptors: effects of HS-142-1, a non-peptide ANP antagonist.
Biochemical and biophysical research communications 1992;189(1):336-42.
1992: T Ishimitsu; Yasunobu Hirata; H Matsuoka; M Ishii; T Sugimoto; Kenji Kangawa; H Matsuo
In vivo and in vitro effects of atrial natriuretic peptide on renin release.
Clinical and experimental pharmacology & physiology 1992;19(10):711-6.
1992: Y Ichiki; Kazuo Kitamura; Kenji Kangawa; M Kawamoto; H Matsuo; Tanenao Eto
Organ distribution and characterization of porcine peptides (VIP, CGRP and PHI) that increase cAMP in rat platelets.
Biochemical and biophysical research communications 1992;187(3):1587-93.
1992: K Shiomi; Masamitsu Nakazato; M Miyazato; Kenji Kangawa; H Matsuo; S Matsukura
Establishment of hypersensitive radioimmunoassay for islet amyloid polypeptide using antiserum specific for its N-terminal region.
Biochemical and biophysical research communications 1992;186(2):1065-73.
1992: Yasunobu Hirata; Etsu Suzuki; Hiroshi Hayakawa; H Matsuoka; T Sugimoto; M Kojima; Kenji Kangawa; Hisayuki Matsuo
Role of endogenous ANP in sodium excretion in rats with experimental pulmonary hypertension.
The American journal of physiology 1992;262(6 Pt 2):H1684-9.
1992: Kazuo Kitamura; Kenji Kangawa; M Kawamoto; Y Ichiki; H Matsuo; Tanenao Eto
Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma.
Biochemical and biophysical research communications 1992;185(1):134-41.
1992: Y Ohyama; K Miyamoto; Y Saito; Naoto Minamino; Kenji Kangawa; Hisayuki Matsuo
Cloning and characterization of two forms of C-type natriuretic peptide receptor in rat brain.
Biochemical and biophysical research communications 1992;183(2):743-9.
1992: Etsu Suzuki; Yasunobu Hirata; H Matsuoka; T Sugimoto; Hiroshi Hayakawa; T Sugimoto; Kenji Kangawa; N Minamino; Hisayuki Matsuo
Characterization of atrial natriuretic peptide in urine from rats treated with a neutral endopeptidase inhibitor.
Biochemical and biophysical research communications 1992;182(3):1270-6.
1992: M Miyazato; Masamitsu Nakazato; K Shiomi; J Aburaya; Kenji Kangawa; H Matsuo; S Matsukura
Molecular forms of islet amyloid polypeptide (IAPP/amylin) in four mammals.
Diabetes research and clinical practice 1992;15(1):31-6.
1991: M Miyazato; Masamitsu Nakazato; K Shiomi; J Aburaya; H Toshimori; Kenji Kangawa; H Matsuo; S Matsukura
Identification and characterization of islet amyloid polypeptide in mammalian gastrointestinal tract.
Biochemical and biophysical research communications 1991;181(1):293-300.
1991: T Kita; O Kida; N Yokota; Tanenao Eto; N Minamino; Kenji Kangawa; H Matsuo; K Tanaka
Effects of brain natriuretic peptide-45, a circulating form of rat brain natriuretic peptide, in spontaneously hypertensive rats.
European journal of pharmacology 1991;202(1):73-9.
1991: Naoto Minamino; Y Makino; H Tateyama; Kenji Kangawa; Hisayuki Matsuo
Characterization of immunoreactive human C-type natriuretic peptide in brain and heart.
Biochemical and biophysical research communications 1991;179(1):535-42.
1991: H Matsuoka; K Fukui; Y Dan; T Ishimitsu; Yasunobu Hirata; K Kimura; T Sugimoto; M Ishii; Kenji Kangawa; H Matsuo
Atrial natriuretic peptide inhibits the aldosterone response to metoclopramide in patients with glomerular disease and essential hypertension.
Clinical and experimental pharmacology & physiology 1991;18(8):557-62.
1991: Yasunobu Hirata; H Matsuoka; Hiroshi Hayakawa; T Sugimoto; Etsu Suzuki; T Sugimoto; Kenji Kangawa; Hisayuki Matsuo
Role of endogenous atrial natriuretic peptide in regulating sodium excretion in spontaneously hypertensive rats. Effects of neutral endopeptidase inhibition.
Hypertension 1991;17(6 Pt 2):1025-32.
1991: N Yokota; Y Yamamoto; M Aburaya; Kazuo Kitamura; Tanenao Eto; Kenji Kangawa; N Minamino; H Matsuo; K Tanaka
Increased secretion of brain natriuretic peptide and atrial natriuretic peptide, but not sufficient to induce natriuresis in rats with nephrotic syndrome.
Biochemical and biophysical research communications 1991;174(1):128-35.
1991: N Yokota; M Aburaya; Y Yamamoto; Johji Kato; Kazuo Kitamura; O Kida; Tanenao Eto; N Minamino; Kenji Kangawa; H Matsuo
Cardiac content of brain natriuretic peptide in DOCA salt-hypertensive rats.
Life sciences 1991;48(5):397-402.
1990: N Yokota; M Aburaya; Y Yamamoto; Johji Kato; Kazuo Kitamura; O Kida; Tanenao Eto; N Minamino; Kenji Kangawa; H Matsuo
Increased plasma brain natriuretic peptide levels in DOCA-salt hypertensive rats: relation to blood pressure and cardiac concentration.
Biochemical and biophysical research communications 1990;173(2):632-8.
1990: Masamitsu Nakazato; J Asai; M Miyazato; S Matsukura; Kenji Kangawa; H Matsuo
Isolation and identification of islet amyloid polypeptide in normal human pancreas.
Regulatory peptides 1990;31(3):179-86.
1990: H Toshimori; R Narita; Masamitsu Nakazato; J Asai; T Mitsukawa; Kenji Kangawa; H Matsuo; S Matsukura
Islet amyloid polypeptide (IAPP) in the gastrointestinal tract and pancreas of man and rat.
Cell and tissue research 1990;262(3):401-6.
1990: Naoto Minamino; Kenji Kangawa; Hisayuki Matsuo
N-terminally extended form of C-type natriuretic peptide (CNP-53) identified in porcine brain.
Biochemical and biophysical research communications 1990;170(2):973-9.
1990: Kazuo Kitamura; Kenji Kangawa; K Tanaka; H Matsuo
Isolation of NPY-25 (neuropeptide Y[12-36]), a potent inhibitor of calmodulin, from porcine brain.
Biochemical and biophysical research communications 1990;169(3):1164-71.
1990: J Asai; Masamitsu Nakazato; M Miyazato; Kenji Kangawa; H Matsuo; S Matsukura
Regional distribution and molecular forms of rat islet amyloid polypeptide.
Biochemical and biophysical research communications 1990;169(2):788-95.
1990: Masamitsu Nakazato; M Miyazato; J Asai; T Mitsukawa; Kenji Kangawa; H Matsuo; S Matsukura
Islet amyloid polypeptide, a novel pancreatic peptide, is a circulating hormone secreted under glucose stimulation.
Biochemical and biophysical research communications 1990;169(2):713-8.
1990: T Mitsukawa; J Takemura; J Asai; Masamitsu Nakazato; Kenji Kangawa; H Matsuo; S Matsukura
Islet amyloid polypeptide response to glucose, insulin, and somatostatin analogue administration.
Diabetes 1990;39(5):639-42.
1989: J Asai; Masamitsu Nakazato; Kenji Kangawa; S Matsukura; H Matsuo
Isolation and sequence determination of rat islet amyloid polypeptide.
Biochemical and biophysical research communications 1989;164(1):400-5.
1989: Masamitsu Nakazato; J Asai; Kenji Kangawa; S Matsukura; H Matsuo
Establishment of radioimmunoassay for human islet amyloid polypeptide and its tissue content and plasma concentration.
Biochemical and biophysical research communications 1989;164(1):394-9.
1989: Yasunobu Hirata; M Ishii; K Fukui; Hiroshi Hayakawa; T Sugimoto; H Matsuoka; T Sugimoto; Kenji Kangawa; Hisayuki Matsuo
Interaction between sympathetic nerve activity and atrial natriuretic peptide with respect to the effects on renal hemodynamics in patients with cardiovascular diseases.
Japanese circulation journal 1989;53(5):446-52.
1989: T Kita; O Kida; Johji Kato; S Nakamura; Tanenao Eto; N Minamino; Kenji Kangawa; H Matsuo; K Tanaka
Natriuretic and hypotensive effects of brain natriuretic peptide in anaesthetized DOCA-salt hypertensive rats.
Clinical and experimental pharmacology & physiology 1989;16(3):185-90.
1989: Masamitsu Nakazato; M Tanaka; S Matsukura; Kenji Kangawa; H Matsuo
Quantitative analysis of amyloid fibril protein in systemic organs of patients with familial amyloidotic polyneuropathy.
Journal of the neurological sciences 1989;89(2-3):235-42.
1989: T Kita; O Kida; Johji Kato; S Nakamura; Tanenao Eto; N Minamino; Kenji Kangawa; H Matsuo; K Tanaka
Natriuretic and hypotensive effects of brain natriuretic peptide (BNP) in spontaneously hypertensive rats.
Life sciences 1989;44(21):1541-5.
1988: Yasunobu Hirata; M Ishii; H Matsuoka; T Sugimoto; M Iizuka; Takashi Serizawa; Osami Kohmoto; T Sugimoto; A Miyata; Kenji Kangawa
Plasma concentration of alpha-hANP and renal responses to alpha-hANP infusion in patients with congestive heart failure and those with chronic renal failure.
Japanese circulation journal 1988;52(12):1459-64.
1988: Yasunobu Hirata; M Ishii; T Sugimoto; H Matsuoka; K Fukui; T Sugimoto; M Yamakado; H Tagawa; A Miyata; Kenji Kangawa
Hormonal and renal effects of atrial natriuretic peptide in patients with secondary hypertension.
Circulation 1988;78(6):1401-10.
1987: Masamitsu Nakazato; M Tanaka; Y Yamamura; T Kurihara; S Matsukura; Kenji Kangawa; H Matsuo
Abnormal transthyretin in asymptomatic relatives in familial amyloidotic polyneuropathy.
Archives of neurology 1987;44(12):1275-8.