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Mitsunobu Kano

Research Profile

Living Beings

Anatomy

Tumor Cell Line

Chemicals & Drugs

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Disorders

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Physiology

Signal Transduction

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Publications

TOP 3
Shourong Wu; Li Yang; Kanjiro Miyata; Nobuhiro Nishiyama; Shinsuke Ohba; Sayaka Tanaka; Ung-il Chung; Mitsunobu R Kano; Vivi Kasim; Kazunori Kataoka; Xueying Liu; Ako Matsuhashi; Yutaka Miura; Makoto Miyagishi
Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner.
Sayaka Yuzawa; Takahiro Einama; Mitsunobu R Kano; Hiroshi Nishihara
PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker.
Qixian Chen; Taisuke Endo; Zhishen Ge; Takehiko Ishii; Keiji Itaka; Mitsunobu R Kano; Hiroaki Kinoh; Makoto Oba; Kensuke Osada; Theofilus A Tockary; Satoshi Uchida; Kazunori Kataoka
Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors.

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All Publications

2013: Shourong Wu; Li Yang; Kanjiro Miyata; Nobuhiro Nishiyama; Shinsuke Ohba; Sayaka Tanaka; Ung-il Chung; Mitsunobu R Kano; Vivi Kasim; Kazunori Kataoka; Xueying Liu; Ako Matsuhashi; Yutaka Miura; Makoto Miyagishi
Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner.
Cancer research 2013;73(6):1787-99.
2012: Sayaka Yuzawa; Takahiro Einama; Mitsunobu R Kano; Hiroshi Nishihara
PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker.
Medical oncology (Northwood, London, England) 2012;29(4):2824-30.
2012: Qixian Chen; Taisuke Endo; Zhishen Ge; Takehiko Ishii; Keiji Itaka; Mitsunobu R Kano; Hiroaki Kinoh; Makoto Oba; Kensuke Osada; Theofilus A Tockary; Satoshi Uchida; Kazunori Kataoka
Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors.
Biomaterials 2012;33(18):4722-30.
2012: Md Rafi; Masakazu Yashiro; P Mi; Kohei Miyazono; Nobuhiro Nishiyama; Horacio Cabral; Kosei Hirakawa; Caname Iwata; Mitsunobu R Kano; Kazunori Kataoka
Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis.
Journal of controlled release : official journal of the Controlled Release Society 2012;159(2):189-96.
2012: Hitomi Hosoya; Hideaki Ijichi; Koji Kadowaki; Kazunori Kataoka; Kazuhiko Koike; Michiya Matsusaki; Kohei Miyazono; Hiroshi Nishihara; Mitsuru Akashi; Horacio Cabral; Mitsunobu R Kano
Engineering fibrotic tissue in pancreatic cancer: a novel three-dimensional model to investigate nanoparticle delivery.
Biochemical and biophysical research communications 2012;419(1):32-7.
2012: Mitsunori Harada; Tatsuyuki Hayashi; Kosei Hirakawa; Kenta Ishii; Caname Iwata; Yasuki Kato; Kohei Miyazono; Hiroyuki Saito; Masakazu Yashiro; Mitsunobu R Kano
NC-6301, a polymeric micelle rationally optimized for effective release of docetaxel, is potent but is less toxic than native docetaxel in vivo.
International journal of nanomedicine 2012;7():2713-27.
2012: Liuzhe Zhang; Hiroshi Nishihara; Mitsunobu R Kano
Pericyte-coverage of human tumor vasculature and nanoparticle permeability.
Biological & pharmaceutical bulletin 2012;35(5):761-6.
2011: Kazuyuki Nakagome; Katsuhide Okunishi; Oh Sasaki; Ryoichi Tanaka; Kazuhiko Yamamoto; Haruo Hanawa; Hiroaki Harada; Mitsuru Imamura; Mitsunobu R Kano; Kimito Kawahata; Taku Matsumoto; Jun-Ichi Miyazaki; He Chang; Makoto Dohi
High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(10):5077-89.
2011: S Ehata; E Johansson; R Katayama; Satoshi Koike; Akira Watanabe; Yuichi Hoshino; Y Katsuno; Akiyoshi Komuro; D Koinuma; Mitsunobu R Kano; M Yashiro; K Hirakawa; Hiroyuki Aburatani; N Fujita; Kohei Miyazono
Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells.
Oncogene 2011;30(14):1693-705.
2011: Mami Murakami; Horacio Cabral; Yu Matsumoto; Shourong Wu; Mitsunobu R Kano; Takao Yamori; Nobuhiro Nishiyama; Kazunori Kataoka
Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting.
Science translational medicine 2011;3(64):64ra2.
2011: Yelena Vachutinsky; Makoto Oba; Kanjiro Miyata; Shigehiro Hiki; Mitsunobu R Kano; Nobuhiro Nishiyama; Hiroyuki Koyama; Kohei Miyazono; Kazunori Kataoka
Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles.
Journal of controlled release : official journal of the Controlled Release Society 2011;149(1):51-7.
2011: Makoto Oba; Kanjiro Miyata; Kensuke Osada; R. James Christie; Mai Sanjoh; Weidong Li; Shigeto Fukushima; Takehiko Ishii; Mitsunobu R Kano; Nobuhiro Nishiyama; Hiroyuki Koyama; Kazunori Kataoka
Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery.
Biomaterials 2011;32(2):652-63.
2010: Hayakazu Sumida; Kyoko Noguchi; Yasuyuki Kihara; Manabu Abe; Keisuke Yanagida; Fumie Hamano; Shinichi Sato; Kunihiko Tamaki; Yasuyuki Morishita; Mitsunobu R Kano; Caname Iwata; Kohei Miyazono; Kenji Sakimura; Takao Shimizu; Satoshi Ishii
LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis.
Blood 2010;116(23):5060-70.
2010: Erik Johansson; Akiyoshi Komuro; Caname Iwata; Akifumi Hagiwara; Yuma Fuse; Akira Watanabe; Yasuyuki Morishita; Hiroyuki Aburatani; Keiko Funa; Mitsunobu R Kano; Kohei Miyazono
Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-β-disrupted diffuse-type gastric carcinoma.
Cancer science 2010;101(11):2398-403.
2010: Hidetaka Ota; Masato Eto; Mitsunobu R Kano; Tomoaki Kahyo; Mitsutoshi Setou; Sumito Ogawa; Katsuya Iijima; Masahiro Akishita; Yasuyoshi Ouchi
Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(11):2205-11.
2010: Michiaki Kumagai; Tridib Kumar Sarma; Horacio Cabral; Sachiko Kaida; Masaki Sekino; Nicholas Herlambang; Kensuke Osada; Mitsunobu R Kano; Nobuhiro Nishiyama; Kazunori Kataoka
Enhanced in vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide-Gold Core-Shell Nanoparticles with Prolonged Blood Circulation Properties.
Macromolecular rapid communications 2010;31(17):1521-8.
2010: Makoto Oba; Yelena Vachutinsky; Kanjiro Miyata; Mitsunobu R Kano; Sorato Ikeda; Nobuhiro Nishiyama; Keiji Itaka; Kohei Miyazono; Hiroyuki Koyama; Kazunori Kataoka
Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble flt-1.
Molecular pharmaceutics 2010;7(2):501-9.
2009: Michiaki Kumagai; Mitsunobu R Kano; Yasuyuki Morishita; Motomi Ota; Yutaka Imai; Nobuhiro Nishiyama; Masaki Sekino; Shoogo Ueno; Kohei Miyazono; Kazunori Kataoka
Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block copolymer-coated magnetite nanoparticles with TGF-beta inhibitor.
Journal of controlled release : official journal of the Controlled Release Society 2009;140(3):306-11.
2009: Ken Kiyono; Hiroshi I Suzuki; Hironori Matsuyama; Yasuyuki Morishita; Akiyoshi Komuro; Mitsunobu R Kano; Koichi Sugimoto; Kohei Miyazono
Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells.
Cancer research 2009;69(23):8844-52.
2009: Ken Kiyono; Hiroshi I Suzuki; Yasuyuki Morishita; Akiyoshi Komuro; Caname Iwata; Masakazu Yashiro; Kosei Hirakawa; Mitsunobu R Kano; Kohei Miyazono
c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma.
Cancer science 2009;100(10):1809-16.
2009: Muri Han; Makoto Oba; Nobuhiro Nishiyama; Mitsunobu R Kano; Shinae Kizaka-Kondoh; Kazunori Kataoka
Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(8):1404-10.
2009: Akiyoshi Komuro; Masakazu Yashiro; Caname Iwata; Yasuyuki Morishita; Erik Johansson; Yoshiko Matsumoto; Akira Watanabe; Hiroyuki Aburatani; Hiroyuki Miyoshi; Ken Kiyono; Yo-taro Shirai; Hiroshi I Suzuki; Kosei Hirakawa; Mitsunobu R Kano; Kohei Miyazono
Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling.
Journal of the National Cancer Institute 2009;101(8):592-604.
2009: Mitsunobu R Kano; Yukari Komuta; Caname Iwata; Masako Oka; Yo-taro Shirai; Yasuyuki Morishita; Yasuyoshi Ouchi; Kazunori Kataoka; Kohei Miyazono
Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-beta receptor inhibitor on extravasation of nanoparticles from neovasculature.
Cancer science 2009;100(1):173-80.
2008: Kanjiro Miyata; Makoto Oba; Mitsunobu R Kano; Shigeto Fukushima; Yelena Vachutinsky; Muri Han; Hiroyuki Koyama; Kohei Miyazono; Nobuhiro Nishiyama; Kazunori Kataoka
Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor tissue.
Pharmaceutical research 2008;25(12):2924-36.
2008: Hidetaka Ota; Masato Eto; Mitsunobu R Kano; Sumito Ogawa; Katsuya Iijima; Masahiro Akishita; Yasuyoshi Ouchi
Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(9):1634-9.
2008: Shourong Wu; Nobuhiro Nishiyama; Mitsunobu R Kano; Yasuyuki Morishita; Kohei Miyazono; Keiji Itaka; Ung-il Chung; Kazunori Kataoka
Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(7):1227-34.
2008: Masako Oka; Caname Iwata; Hiroshi I Suzuki; Kunihiko Kiyono; Yasuyuki Morishita; Tetsuro Watabe; Akiyoshi Komuro; Mitsunobu R Kano; Kohei Miyazono
Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis.
Blood 2008;111(9):4571-9.
2007: Caname Iwata; Mitsunobu R Kano; Akiyoshi Komuro; Masako Oka; Kunihiko Kiyono; Erik Johansson; Yasuyuki Morishita; Masakazu Yashiro; Kosei Hirakawa; Michio Kaminishi; Kohei Miyazono
Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis.
Cancer research 2007;67(21):10181-9.
2007: Kazuyuki Nakagome; Makoto Dohi; Katsuhide Okunishi; Ryoichi Tanaka; Taku Kouro; Mitsunobu R Kano; Kohei Miyazono; Jun-ichi Miyazaki; Kiyoshi Takatsu; Kazuhiko Yamamoto
IL-5-induced hypereosinophilia suppresses the antigen-induced immune response via a TGF-beta-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):284-94.
2007: Mitsunobu R Kano; Younsoo Bae; Caname Iwata; Yasuyuki Morishita; Masakazu Yashiro; Masako Oka; Tomoko Fujii; Akiyoshi Komuro; Kunihiko Kiyono; Michio Kaminishi; Kosei Hirakawa; Yasuyoshi Ouchi; Nobuhiro Nishiyama; Kazunori Kataoka; Kohei Miyazono
Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3460-5.
2005: Mitsunobu R Kano; Yasuyuki Morishita; Caname Iwata; Shigeru Iwasaka; Tetsuro Watabe; Yasuyoshi Ouchi; Kohei Miyazono; Keiji Miyazawa
VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling.
Journal of cell science 2005;118(Pt 16):3759-68.

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