Geoffrey Kansas

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Boylan Kristin L M; Gosse Mary A; Staggs Sarah E; Janz Siegfried; Grindle Suzanne; Kansas Geoffrey S; Van Ness Brian G
A transgenic mouse model of plasma cell malignancy shows phenotypic, cytogenetic, and gene expression heterogeneity similar to human multiple myeloma.
Mathur Anubhav N; Chang Hua-Chen; Zisoulis Dimitrios G; Stritesky Gretta L; Yu Qing; O'Malley John T; Kapur Reuben; Levy David E; Kansas Geoffrey S; Kaplan Mark H
Stat3 and Stat4 direct development of IL-17-secreting Th cells.
Mathur Anubhav N; Chang Hua-Chen; Zisoulis Dimitrios G; Kapur Reuben; Belladonna Maria Laura; Kansas Geoffrey S; Kaplan Mark H
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.

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2007: Boylan Kristin L M; Gosse Mary A; Staggs Sarah E; Janz Siegfried; Grindle Suzanne; Kansas Geoffrey S; Van Ness Brian G
A transgenic mouse model of plasma cell malignancy shows phenotypic, cytogenetic, and gene expression heterogeneity similar to human multiple myeloma.
Cancer research 2007;67(9):4069-78.
2007: Mathur Anubhav N; Chang Hua-Chen; Zisoulis Dimitrios G; Stritesky Gretta L; Yu Qing; O'Malley John T; Kapur Reuben; Levy David E; Kansas Geoffrey S; Kaplan Mark H
Stat3 and Stat4 direct development of IL-17-secreting Th cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4901-7.
2006: Mathur Anubhav N; Chang Hua-Chen; Zisoulis Dimitrios G; Kapur Reuben; Belladonna Maria Laura; Kansas Geoffrey S; Kaplan Mark H
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.
Blood 2006;108(5):1595-601.
2006: Fornek Jamie L; Tygrett Lorraine T; Waldschmidt Thomas J; Poli Valeria; Rickert Robert C; Kansas Geoffrey S
Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells.
Blood 2006;107(3):1085-91.
2005: Underhill Greg H; Zisoulis Dimitrios G; Kolli K Pallav; Ellies Lesley G; Marth Jamey D; Kansas Geoffrey S
A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells.
Blood 2005;106(12):3867-73.
2004: Zisoulis Dimitrios G; Kansas Geoffrey S
H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells.
The Journal of biological chemistry 2004;279(38):39495-504.
2004: Ley Klaus; Kansas Geoffrey S
Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation.
Nature reviews. Immunology 2004;4(5):325-35.
2003: Underhill Gregory H; Kolli K Pallav; Kansas Geoffrey S
Complexity within the plasma cell compartment of mice deficient in both E- and P-selectin: implications for plasma cell differentiation.
Blood 2003;102(12):4076-83.
2003: Dwir Oren; Solomon Ariel; Mangan Shmuel; Kansas Geoffrey S; Schwarz Ulrich S; Alon Ronen
Avidity enhancement of L-selectin bonds by flow: shear-promoted rotation of leukocytes turn labile bonds into functional tethers.
The Journal of cell biology 2003;163(3):649-59.
2003: Barry Sheila M; Zisoulis Dimitrios G; Neal Joel W; Clipstone Neil A; Kansas Geoffrey S
Induction of FucT-VII by the Ras/MAP kinase cascade in Jurkat T cells.
Blood 2003;102(5):1771-8.
2003: Haddad Wael; Cooper Cristine J; Zhang Zheng; Brown Jeffrey B; Zhu Yuechun; Issekutz Andrew; Fuss Ivan; Lee Hae-ock; Kansas Geoffrey S; Barrett Terrence A
P-selectin and P-selectin glycoprotein ligand 1 are major determinants for Th1 cell recruitment to nonlymphoid effector sites in the intestinal lamina propria.
The Journal of experimental medicine 2003;198(3):369-77.
2003: Underhill Gregory H; George David; Bremer Eric G; Kansas Geoffrey S
Gene expression profiling reveals a highly specialized genetic program of plasma cells.
Blood 2003;101(10):4013-21.
2003: Fernandes Laura S; Conde Ian D; Wayne Smith C; Kansas Geoffrey S; Snapp Karen R; Bennet Nelson; Ballantyne Christie; McIntire Larry V; O'Brian Smith E; Klem Jeffrey A; Mathew Shiba; Frangogiannis Nikolaos; Turner Nancy A; Maresh Kelley J; Kleiman Neal S
Platelet-monocyte complex formation: effect of blocking PSGL-1 alone, and in combination with alphaIIbbeta3 and alphaMbeta2, in coronary stenting.
Thrombosis research 2003;111(3):171-7.
2002: Ellies Lesley G; Sperandio Markus; Underhill Gregory H; Yousif James; Smith Michael; Priatel John J; Kansas Geoffrey S; Ley Klaus; Marth Jamey D
Sialyltransferase specificity in selectin ligand formation.
Blood 2002;100(10):3618-25.
2002: Minges Wols Heather A; Underhill Gregory H; Kansas Geoffrey S; Witte Pamela L
The role of bone marrow-derived stromal cells in the maintenance of plasma cell longevity.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4213-21.
2002: Kanamori Akiko; Kojima Naoya; Uchimura Kenji; Muramatsu Takashi; Tamatani Takuya; Berndt Michael C; Kansas Geoffrey S; Kannagi Reiji
Distinct sulfation requirements of selectins disclosed using cells that support rolling mediated by all three selectins under shear flow. L-selectin prefers carbohydrate 6-sulfation totyrosine sulfation, whereas p-selectin does not.
The Journal of biological chemistry 2002;277(36):32578-86.
2002: Snapp Karen R; Heitzig Christine E; Kansas Geoffrey S
Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectin.
Blood 2002;99(12):4494-502.
2002: Dwir Oren; Steeber Douglas A; Schwarz Ulrich S; Camphausen Raymond T; Kansas Geoffrey S; Tedder Thomas F; Alon Ronen
L-selectin dimerization enhances tether formation to properly spaced ligand.
The Journal of biological chemistry 2002;277(24):21130-9.
2002: Underhill Gregory H; Minges Wols Heather A; Fornek Jamie L; Witte Pamela L; Kansas Geoffrey S;
IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules.
Blood 2002;99(8):2905-12.
2002: Uchimura Kenji; El-Fasakhany Fathy M; Hori Mayuko; Hemmerich Stefan; Blink Sarah E; Kansas Geoffrey S; Kanamori Akiko; Kumamoto Kensuke; Kannagi Reiji; Muramatsu Takashi
Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression.
The Journal of biological chemistry 2002;277(6):3979-84.
2001: Dwir O; Kansas G S; Alon R
Cytoplasmic anchorage of L-selectin controls leukocyte capture and rolling by increasing the mechanical stability of the selectin tether.
The Journal of cell biology 2001;155(1):145-56.
2001: White S J; Underhill G H; Kaplan M H; Kansas G S
Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):628-31.
2001: Snapp K R; Heitzig C E; Ellies L G; Marth J D; Kansas G S
Differential requirements for the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase in biosynthesis of ligands for E-selectin and P-selectin.
Blood 2001;97(12):3806-11.
2000: Wagers A J; Kansas G S
Potent induction of alpha(1,3)-fucosyltransferase VII in activated CD4+ T cells by TGF-beta 1 through a p38 mitogen-activated protein kinase-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5011-6.
2000: Herron M J; Nelson C M; Larson J; Snapp K R; Kansas G S; Goodman J L
Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1.
Science (New York, N.Y.) 2000;288(5471):1653-6.
2000: Dwir O; Kansas G S; Alon R
An activated L-selectin mutant with conserved equilibrium binding properties but enhanced ligand recognition under shear flow.
The Journal of biological chemistry 2000;275(25):18682-91.
2000: Alonso-Lebrero J L; Serrador J M; Domínguez-Jiménez C; Barreiro O; Luque A; del Pozo M A; Snapp K; Kansas G; Schwartz-Albiez R; Furthmayr H; Lozano F; Sánchez-Madrid F
Polarization and interaction of adhesion molecules P-selectin glycoprotein ligand 1 and intercellular adhesion molecule 3 with moesin and ezrin in myeloid cells.
Blood 2000;95(7):2413-9.
2000: Hentzen E R; Neelamegham S; Kansas G S; Benanti J A; McIntire L V; Smith C W; Simon S I
Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule-1.
Blood 2000;95(3):911-20.
1999: Lévesque J P; Zannettino A C; Pudney M; Niutta S; Haylock D N; Snapp K R; Kansas G S; Berndt M C; Simmons P J
PSGL-1-mediated adhesion of human hematopoietic progenitors to P-selectin results in suppression of hematopoiesis.
Immunity 1999;11(3):369-78.
1999: Romo G M; Dong J F; Schade A J; Gardiner E E; Kansas G S; Li C Q; McIntire L V; Berndt M C; López J A
The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin.
The Journal of experimental medicine 1999;190(6):803-14.
1999: Montoya M C; Holtmann K; Snapp K R; Borges E; Sánchez-Madrid F; Luscinskas F W; Kansas G; Vestweber D; de Landázuri M O
Memory B lymphocytes from secondary lymphoid organs interact with E-selectin through a novel glycoprotein ligand.
The Journal of clinical investigation 1999;103(9):1317-27.
1999: Kimura N; Mitsuoka C; Kanamori A; Hiraiwa N; Uchimura K; Muramatsu T; Tamatani T; Kansas G S; Kannagi R
Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of alpha1-->3 fucosyltransferase VII and newly cloned GlcNAcbeta:6-sulfotransferase cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4530-5.
1999: Lim Y C; Henault L; Wagers A J; Kansas G S; Luscinskas F W; Lichtman A H
Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3193-201.
1998: Wagers A J; Waters C M; Stoolman L M; Kansas G S
Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on alpha1, 3-fucosyltransferase VII gene expression.
The Journal of experimental medicine 1998;188(12):2225-31.
1998: Konstantopoulos K; Neelamegham S; Burns A R; Hentzen E; Kansas G S; Snapp K R; Berg E L; Hellums J D; Smith C W; McIntire L V; Simon S I
Venous levels of shear support neutrophil-platelet adhesion and neutrophil aggregation in blood via P-selectin and beta2-integrin.
Circulation 1998;98(9):873-82.
1998: Lim Y C; Snapp K; Kansas G S; Camphausen R; Ding H; Luscinskas F W
Important contributions of P-selectin glycoprotein ligand-1-mediated secondary capture to human monocyte adhesion to P-selectin, E-selectin, and TNF-alpha-activated endothelium under flow in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2501-8.
1998: Snapp K R; Craig R; Herron M; Nelson R D; Stoolman L M; Kansas G S
Dimerization of P-selectin glycoprotein ligand-1 (PSGL-1) required for optimal recognition of P-selectin.
The Journal of cell biology 1998;142(1):263-70.
1998: Wagers A J; Stoolman L M; Craig R; Knibbs R N; Kansas G S
An sLex-deficient variant of HL60 cells exhibits high levels of adhesion to vascular selectins: further evidence that HECA-452 and CSLEX1 monoclonal antibody epitopes are not essential for high avidity binding to vascular selectins.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):5122-9.
1998: Gerszten R E; Lim Y C; Ding H T; Snapp K; Kansas G; Dichek D A; Cabañas C; Sánchez-Madrid F; Gimbrone M A; Rosenzweig A; Luscinskas F W
Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: implications for atherogenesis.
Circulation research 1998;82(8):871-8.
1998: Ramos C L; Smith M J; Snapp K R; Kansas G S; Stickney G W; Ley K; Lawrence M B
Functional characterization of L-selectin ligands on human neutrophils and leukemia cell lines: evidence for mucinlike ligand activity distinct from P-selectin glycoprotein ligand-1.
Blood 1998;91(3):1067-75.
1998: Snapp K R; Ding H; Atkins K; Warnke R; Luscinskas F W; Kansas G S
A novel P-selectin glycoprotein ligand-1 monoclonal antibody recognizes an epitope within the tyrosine sulfate motif of human PSGL-1 and blocks recognition of both P- and L-selectin.
Blood 1998;91(1):154-64.
1997: Wagers A J; Stoolman L M; Kannagi R; Craig R; Kansas G S
Expression of leukocyte fucosyltransferases regulates binding to E-selectin: relationship to previously implicated carbohydrate epitopes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1917-29.
1997: Goetz D J; Greif D M; Ding H; Camphausen R T; Howes S; Comess K M; Snapp K R; Kansas G S; Luscinskas F W
Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin.
The Journal of cell biology 1997;137(2):509-19.
1997: Snapp K R; Wagers A J; Craig R; Stoolman L M; Kansas G S
P-selectin glycoprotein ligand-1 is essential for adhesion to P-selectin but not E-selectin in stably transfected hematopoietic cell lines.
Blood 1997;89(3):896-901.
1997: Lawrence M B; Kansas G S; Kunkel E J; Ley K
Threshold levels of fluid shear promote leukocyte adhesion through selectins (CD62L,P,E)
The Journal of cell biology 1997;136(3):717-27.
1996: Kansas G S
Selectins and their ligands: current concepts and controversies.
Blood 1996;88(9):3259-87.
1996: Wagers A J; Lowe J B; Kansas G S
An important role for the alpha 1,3 fucosyltransferase, FucT-VII, in leukocyte adhesion to E-selectin.
Blood 1996;88(6):2125-32.
1996: Kansas G S; Pavalko F M
The cytoplasmic domains of E- and P-selectin do not constitutively interact with alpha-actinin and are not essential for leukocyte adhesion.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(1):321-5.
1995: Ley K; Zakrzewicz A; Hanski C; Stoolman L M; Kansas G S
Sialylated O-glycans and L-selectin sequentially mediate myeloid cell rolling in vivo.
Blood 1995;85(12):3727-35.
1995: Pavalko F M; Walker D M; Graham L; Goheen M; Doerschuk C M; Kansas G S
The cytoplasmic domain of L-selectin interacts with cytoskeletal proteins via alpha-actinin: receptor positioning in microvilli does not require interaction with alpha-actinin.
The Journal of cell biology 1995;129(4):1155-64.
1995: Salgia R; Li J L; Lo S H; Brunkhorst B; Kansas G S; Sobhany E S; Sun Y; Pisick E; Hallek M; Ernst T
Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL.
The Journal of biological chemistry 1995;270(10):5039-47.
1995: Gibson R M; Kansas G S; Tedder T F; Furie B; Furie B C
Lectin and epidermal growth factor domains of P-selectin at physiologic density are the recognition unit for leukocyte binding.
Blood 1995;85(1):151-8.
1994: Luscinskas F W; Kansas G S; Ding H; Pizcueta P; Schleiffenbaum B E; Tedder T F; Gimbrone M A
Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins.
The Journal of cell biology 1994;125(6):1417-27.
1994: Kansas G S; Saunders K B; Ley K; Zakrzewicz A; Gibson R M; Furie B C; Furie B; Tedder T F
A role for the epidermal growth factor-like domain of P-selectin in ligand recognition and cell adhesion.
The Journal of cell biology 1994;124(4):609-18.
1993: Cannistra S A; Kansas G S; Niloff J; DeFranzo B; Kim Y; Ottensmeier C
Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44H.
Cancer research 1993;53(16):3830-8.
1993: Tedder T F; Luscinskas W; Kansas G S
Regulation of leukocyte migration by L-selectin: mechanisms, domains and ligands.
Behring Institute Mitteilungen 1993;(92):165-77.
1993: Kansas G S; Ley K; Munro J M; Tedder T F
Regulation of leukocyte rolling and adhesion to high endothelial venules through the cytoplasmic domain of L-selectin.
The Journal of experimental medicine 1993;177(3):833-8.
1992: Bradbury L E; Kansas G S; Levy S; Evans R L; Tedder T F
The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(9):2841-50.
1992: Kansas G S
Structure and function of L-selectin.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1992;100(4):287-93.
1992: Kansas G S; Cambier J C; Tedder T F
CD4 binding to major histocompatibility complex class II antigens induces LFA-1-dependent and -independent homotypic adhesion of B lymphocytes.
European journal of immunology 1992;22(1):147-52.
1991: Kansas G S; Tedder T F
Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(12):4094-102.
1991: Spertini O; Luscinskas F W; Kansas G S; Munro J M; Griffin J D; Gimbrone M A; Tedder T F
Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(8):2565-73.
1991: Spertini O; Kansas G S; Reimann K A; Mackay C R; Tedder T F
Function and evolutionary conservation of distinct epitopes on the leukocyte adhesion molecule-1 (TQ-1, Leu-8) that regulate leukocyte migration.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(3):942-9.
1991: Kansas G S; Spertini O; Stoolman L M; Tedder T F
Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1.
The Journal of cell biology 1991;114(2):351-8.
1991: Kansas G S; Wood G S; Tedder T F
Expression, distribution, and biochemistry of human CD39. Role in activation-associated homotypic adhesion of lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2235-44.
1991: Spertini O; Kansas G S; Munro J M; Griffin J D; Tedder T F
Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin.
Nature 1991;349(6311):691-4.

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Geoffrey Kansas

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