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Geoffrey Kansas

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Sarita Sehra; Yongxue Yao; Michael D Howell; Evelyn T Nguyen; Geoffrey S Kansas; Donald Y M Leung; Jeffrey B Travers; Mark H Kaplan
IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation.
Kristin L M Boylan; Mary A Gosse; Sarah E Staggs; Siegfried Janz; Suzanne Grindle; Geoffrey S Kansas; Brian G Van Ness
A transgenic mouse model of plasma cell malignancy shows phenotypic, cytogenetic, and gene expression heterogeneity similar to human multiple myeloma.
Anubhav N Mathur; Hua-Chen Chang; Dimitrios G Zisoulis; Gretta L Stritesky; Qing Yu; John T O'Malley; Reuben Kapur; David E Levy; Geoffrey S Kansas; Mark H Kaplan
Stat3 and Stat4 direct development of IL-17-secreting Th cells.

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All Publications

2010: Sarita Sehra; Yongxue Yao; Michael D Howell; Evelyn T Nguyen; Geoffrey S Kansas; Donald Y M Leung; Jeffrey B Travers; Mark H Kaplan
IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(6):3186-90.
2007: Kristin L M Boylan; Mary A Gosse; Sarah E Staggs; Siegfried Janz; Suzanne Grindle; Geoffrey S Kansas; Brian G Van Ness
A transgenic mouse model of plasma cell malignancy shows phenotypic, cytogenetic, and gene expression heterogeneity similar to human multiple myeloma.
Cancer research 2007;67(9):4069-78.
2007: Anubhav N Mathur; Hua-Chen Chang; Dimitrios G Zisoulis; Gretta L Stritesky; Qing Yu; John T O'Malley; Reuben Kapur; David E Levy; Geoffrey S Kansas; Mark H Kaplan
Stat3 and Stat4 direct development of IL-17-secreting Th cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4901-7.
2006: Anubhav N Mathur; Hua-Chen Chang; Dimitrios G Zisoulis; Reuben Kapur; Maria Laura Belladonna; Geoffrey S Kansas; Mark H Kaplan
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.
Blood 2006;108(5):1595-601.
2006: Jamie L Fornek; Lorraine T Tygrett; Thomas J Waldschmidt; Valeria Poli; Robert C Rickert; Geoffrey S Kansas
Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells.
Blood 2006;107(3):1085-91.
2005: Gregory H Underhill; Dimitrios G Zisoulis; K Pallav Kolli; Lesley G Ellies; Jamey D Marth; Geoffrey S Kansas
A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells.
Blood 2005;106(12):3867-73.
2004: Dimitrios G Zisoulis; Geoffrey S Kansas
H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells.
The Journal of biological chemistry 2004;279(38):39495-504.
2004: Klaus Ley; Geoffrey S Kansas
Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation.
Nature reviews. Immunology 2004;4(5):325-35.
2003: Gregory H Underhill; K Pallav Kolli; Geoffrey S Kansas
Complexity within the plasma cell compartment of mice deficient in both E- and P-selectin: implications for plasma cell differentiation.
Blood 2003;102(12):4076-83.
2003: Oren Dwir; Ariel Solomon; Shmuel Mangan; Geoffrey S Kansas; Ulrich S Schwarz; Ronen Alon
Avidity enhancement of L-selectin bonds by flow: shear-promoted rotation of leukocytes turn labile bonds into functional tethers.
The Journal of cell biology 2003;163(3):649-59.
2003: Sheila M Barry; Dimitrios G Zisoulis; Joel W Neal; Neil A Clipstone; Geoffrey S Kansas
Induction of FucT-VII by the Ras/MAP kinase cascade in Jurkat T cells.
Blood 2003;102(5):1771-8.
2003: Wael Haddad; Cristine J Cooper; Zheng Zhang; Jeffrey B Brown; Yuechun Zhu; Andrew Issekutz; Ivan Fuss; Hae-ock Lee; Geoffrey S Kansas; Terrence Anthony Barrett
P-selectin and P-selectin glycoprotein ligand 1 are major determinants for Th1 cell recruitment to nonlymphoid effector sites in the intestinal lamina propria.
The Journal of experimental medicine 2003;198(3):369-77.
2003: Gregory H Underhill; David George; Eric G Bremer; Geoffrey S Kansas
Gene expression profiling reveals a highly specialized genetic program of plasma cells.
Blood 2003;101(10):4013-21.
2003: Laura S Fernandes; Ian D Conde; C Wayne Smith; Geoffrey S Kansas; Karen R. Snapp; Nelson Bennet; Christie M Ballantyne; Larry V McIntire; E O'Brian Smith; Jeffrey A Klem; Shiba Mathew; Nikolaos G Frangogiannis; Nancy A Turner; Kelly Maresh; Neal S Kleiman
Platelet-monocyte complex formation: effect of blocking PSGL-1 alone, and in combination with alphaIIbbeta3 and alphaMbeta2, in coronary stenting.
Thrombosis research 2003;111(3):171-7.
2002: Lesley G Ellies; Markus Sperandio; Gregory H Underhill; James Yousif; Michael Smith; John J Priatel; Geoffrey S Kansas; Klaus Ley; Jamey D Marth
Sialyltransferase specificity in selectin ligand formation.
Blood 2002;100(10):3618-25.
2002: Heather A Minges-Wols; Gregory H Underhill; Geoffrey S Kansas; Pamela L Witte
The role of bone marrow-derived stromal cells in the maintenance of plasma cell longevity.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4213-21.
2002: Akiko Kanamori; Naoya Kojima; Kenji Uchimura; Takashi Muramatsu; Takuya Tamatani; Michael C Berndt; Geoffrey S Kansas; Reiji Kannagi
Distinct sulfation requirements of selectins disclosed using cells that support rolling mediated by all three selectins under shear flow. L-selectin prefers carbohydrate 6-sulfation totyrosine sulfation, whereas p-selectin does not.
The Journal of biological chemistry 2002;277(36):32578-86.
2002: Karen R. Snapp; Christine E Heitzig; Geoffrey S Kansas
Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectin.
Blood 2002;99(12):4494-502.
2002: Oren Dwir; Douglas A Steeber; Ulrich S Schwarz; Raymond T Camphausen; Geoffrey S Kansas; Thomas F Tedder; Ronen Alon
L-selectin dimerization enhances tether formation to properly spaced ligand.
The Journal of biological chemistry 2002;277(24):21130-9.
2002: Gregory H Underhill; Heather A Minges Wols; Jamie L Fornek; Pamela L Witte; Geoffrey S Kansas; Heather A Minges-Wols
IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules.
Blood 2002;99(8):2905-12.
2002: Kenji Uchimura; Fathy M El-Fasakhany; Mayuko Hori; Stefan Hemmerich; Sarah E Blink; Geoffrey S Kansas; Akiko Kanamori; Kensuke Kumamoto; Reiji Kannagi; Takashi Muramatsu
Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression.
The Journal of biological chemistry 2002;277(6):3979-84.
2001: Oren Dwir; Geoffrey S Kansas; Ronen Alon
Cytoplasmic anchorage of L-selectin controls leukocyte capture and rolling by increasing the mechanical stability of the selectin tether.
The Journal of cell biology 2001;155(1):145-56.
2001: S J White; Gregory H Underhill; M H Kaplan; Geoffrey S Kansas
Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):628-31.
2001: Karen R. Snapp; C E Heitzig; Lesley G Ellies; Jamey D Marth; Geoffrey S Kansas
Differential requirements for the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase in biosynthesis of ligands for E-selectin and P-selectin.
Blood 2001;97(12):3806-11.
2000: Amy J Wagers; Geoffrey S Kansas
Potent induction of alpha(1,3)-fucosyltransferase VII in activated CD4+ T cells by TGF-beta 1 through a p38 mitogen-activated protein kinase-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5011-6.
2000: Oren Dwir; Geoffrey S Kansas; Ronen Alon
An activated L-selectin mutant with conserved equilibrium binding properties but enhanced ligand recognition under shear flow.
The Journal of biological chemistry 2000;275(25):18682-91.
2000: Michael J Herron; Curtis M Nelson; J Larson; Karen R. Snapp; Geoffrey S Kansas; Jesse Goodman
Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1.
Science (New York, N.Y.) 2000;288(5471):1653-6.
2000: José Luis Alonso-Lebrero; Juan M Serrador; Carmen Domínguez-Jiménez; Olga Barreiro; Alfonso Luque; MA del Pozo; Karen R. Snapp; Geoffrey S Kansas; Reinhard Schwartz-Albiez; Heinz Furthmayr; Francisco Lozano; Francisco Sánchez-Madrid
Polarization and interaction of adhesion molecules P-selectin glycoprotein ligand 1 and intercellular adhesion molecule 3 with moesin and ezrin in myeloid cells.
Blood 2000;95(7):2413-9.
2000: Eric R Hentzen; Sriram Neelamegham; Geoffrey S Kansas; J A Benanti; Larry V McIntire; C Wayne Smith; Scott I Simon
Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule-1.
Blood 2000;95(3):911-20.
1999: Gabriel M Romo; Jing-fei Dong; Alicia J Schade; Elizabeth E Gardiner; Geoffrey S Kansas; Chester Q Li; Larry V McIntire; Michael C Berndt; José A López
The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin.
The Journal of experimental medicine 1999;190(6):803-14.
1999: Jean-Pierre Lévesque; Andrew C W Zannettino; M Pudney; Silvana Niutta; David N Haylock; Karen R. Snapp; Geoffrey S Kansas; M C Berndt; Paul J Simmons
PSGL-1-mediated adhesion of human hematopoietic progenitors to P-selectin results in suppression of hematopoiesis.
Immunity 1999;11(3):369-78.
1999: María C Montoya; K Holtmann; Karen R. Snapp; E Borges; Francisco Sánchez-Madrid; Francis W Luscinskas; Geoffrey S Kansas; Dietmar Vestweber; Manuel O de Landázuri
Memory B lymphocytes from secondary lymphoid organs interact with E-selectin through a novel glycoprotein ligand.
The Journal of clinical investigation 1999;103(9):1317-27.
1999: N Kimura; C Mitsuoka; Akiko Kanamori; Noriko Hiraiwa; Kenji Uchimura; Takashi Muramatsu; Takuya Tamatani; Geoffrey S Kansas; Reiji Kannagi
Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of alpha1-->3 fucosyltransferase VII and newly cloned GlcNAcbeta:6-sulfotransferase cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4530-5.
1999: Yaw-Chyn Lim; LE Henault; Amy J Wagers; Geoffrey S Kansas; Francis W Luscinskas; Andrew H Lichtman
Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3193-201.
1998: Amy J Wagers; Christopher M Waters; Lloyd M Stoolman; Geoffrey S Kansas
Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on alpha1, 3-fucosyltransferase VII gene expression.
The Journal of experimental medicine 1998;188(12):2225-31.
1998: Konstantinos Konstantopoulos; Sriram Neelamegham; Alan R Burns; Eric R Hentzen; Geoffrey S Kansas; Karen R. Snapp; Ellen L Berg; J David Hellums; C Wayne Smith; Larry V McIntire; Scott I Simon
Venous levels of shear support neutrophil-platelet adhesion and neutrophil aggregation in blood via P-selectin and beta2-integrin.
Circulation 1998;98(9):873-82.
1998: Yaw-Chyn Lim; Karen R. Snapp; Geoffrey S Kansas; Raymond T Camphausen; H Ding; Francis W Luscinskas
Important contributions of P-selectin glycoprotein ligand-1-mediated secondary capture to human monocyte adhesion to P-selectin, E-selectin, and TNF-alpha-activated endothelium under flow in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2501-8.
1998: Karen R. Snapp; R Craig; Michael J Herron; R D Nelson; Lloyd M Stoolman; Geoffrey S Kansas
Dimerization of P-selectin glycoprotein ligand-1 (PSGL-1) required for optimal recognition of P-selectin.
The Journal of cell biology 1998;142(1):263-70.
1998: Amy J Wagers; Lloyd M Stoolman; R Craig; Randall N Knibbs; Geoffrey S Kansas
An sLex-deficient variant of HL60 cells exhibits high levels of adhesion to vascular selectins: further evidence that HECA-452 and CSLEX1 monoclonal antibody epitopes are not essential for high avidity binding to vascular selectins.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):5122-9.
1998: Robert E Gerszten; Yaw-Chyn Lim; H T Ding; Karen R. Snapp; Geoffrey S Kansas; D A Dichek; C Cabañas; Francisco Sánchez-Madrid; Michael A Gimbrone; Anthony Rosenzweig; Francis W Luscinskas
Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: implications for atherogenesis.
Circulation research 1998;82(8):871-8.
1998: CL Ramos; McRae J Smith; Karen R. Snapp; Geoffrey S Kansas; G W Stickney; Klaus Ley; Michael B Lawrence
Functional characterization of L-selectin ligands on human neutrophils and leukemia cell lines: evidence for mucinlike ligand activity distinct from P-selectin glycoprotein ligand-1.
Blood 1998;91(3):1067-75.
1998: Karen R. Snapp; H Ding; K Atkins; R Warnke; Francis W Luscinskas; Geoffrey S Kansas
A novel P-selectin glycoprotein ligand-1 monoclonal antibody recognizes an epitope within the tyrosine sulfate motif of human PSGL-1 and blocks recognition of both P- and L-selectin.
Blood 1998;91(1):154-64.
1997: Amy J Wagers; Lloyd M Stoolman; R Kannagi; R Craig; Geoffrey S Kansas
Expression of leukocyte fucosyltransferases regulates binding to E-selectin: relationship to previously implicated carbohydrate epitopes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1917-29.
1997: Douglas J Goetz; Daniel M Greif; H Ding; Raymond T Camphausen; S Howes; K M Comess; Karen R. Snapp; Geoffrey S Kansas; Francis W Luscinskas
Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin.
The Journal of cell biology 1997;137(2):509-19.
1997: Michael B Lawrence; Geoffrey S Kansas; EJ Kunkel; Klaus Ley
Threshold levels of fluid shear promote leukocyte adhesion through selectins (CD62L,P,E)
The Journal of cell biology 1997;136(3):717-27.
1997: Karen R. Snapp; Amy J Wagers; R Craig; Lloyd M Stoolman; Geoffrey S Kansas
P-selectin glycoprotein ligand-1 is essential for adhesion to P-selectin but not E-selectin in stably transfected hematopoietic cell lines.
Blood 1997;89(3):896-901.
1996: Geoffrey S Kansas
Selectins and their ligands: current concepts and controversies.
Blood 1996;88(9):3259-87.
1996: Amy J Wagers; J B Lowe; Geoffrey S Kansas
An important role for the alpha 1,3 fucosyltransferase, FucT-VII, in leukocyte adhesion to E-selectin.
Blood 1996;88(6):2125-32.
1996: Geoffrey S Kansas; Fredrick M Pavalko
The cytoplasmic domains of E- and P-selectin do not constitutively interact with alpha-actinin and are not essential for leukocyte adhesion.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(1):321-5.
1995: Klaus Ley; Andreas Zakrzewicz; C Hanski; Lloyd M Stoolman; Geoffrey S Kansas
Sialylated O-glycans and L-selectin sequentially mediate myeloid cell rolling in vivo.
Blood 1995;85(12):3727-35.
1995: Fredrick M Pavalko; D M Walker; L Graham; MP Goheen; Claire Doerschuk; Geoffrey S Kansas
The cytoplasmic domain of L-selectin interacts with cytoskeletal proteins via alpha-actinin: receptor positioning in microvilli does not require interaction with alpha-actinin.
The Journal of cell biology 1995;129(4):1155-64.
1995: Ravi Salgia; J L Li; Su Hao Lo; B Brunkhorst; Geoffrey S Kansas; E S Sobhany; YanPing Sun; Evan Pisick; Michael Hallek; T Ernst
Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL.
The Journal of biological chemistry 1995;270(10):5039-47.
1995: R M Gibson; Geoffrey S Kansas; T F Tedder; B Furie; B C Furie
Lectin and epidermal growth factor domains of P-selectin at physiologic density are the recognition unit for leukocyte binding.
Blood 1995;85(1):151-8.
1994: Francis W Luscinskas; Geoffrey S Kansas; H Ding; P Pizcueta; B E Schleiffenbaum; T F Tedder; Michael A Gimbrone
Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins.
The Journal of cell biology 1994;125(6):1417-27.
1994: Geoffrey S Kansas; K B Saunders; Klaus Ley; Andreas Zakrzewicz; R M Gibson; B C Furie; B Furie; Thomas F Tedder
A role for the epidermal growth factor-like domain of P-selectin in ligand recognition and cell adhesion.
The Journal of cell biology 1994;124(4):609-18.
1993: Stephen A Cannistra; Geoffrey S Kansas; J Niloff; B DeFranzo; Y Kim; C Ottensmeier
Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44H.
Cancer research 1993;53(16):3830-8.
1993: Thomas F Tedder; W Luscinskas; Geoffrey S Kansas
Regulation of leukocyte migration by L-selectin: mechanisms, domains and ligands.
Behring Institute Mitteilungen 1993;(92):165-77.
1993: Geoffrey S Kansas; Klaus Ley; J M Munro; Thomas F Tedder
Regulation of leukocyte rolling and adhesion to high endothelial venules through the cytoplasmic domain of L-selectin.
The Journal of experimental medicine 1993;177(3):833-8.
1992: L E Bradbury; Geoffrey S Kansas; S Levy; R L Evans; Thomas F Tedder
The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(9):2841-50.
1992: Geoffrey S Kansas
Structure and function of L-selectin.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1992;100(4):287-93.
1992: Geoffrey S Kansas; J C Cambier; Thomas F Tedder
CD4 binding to major histocompatibility complex class II antigens induces LFA-1-dependent and -independent homotypic adhesion of B lymphocytes.
European journal of immunology 1992;22(1):147-52.
1991: Geoffrey S Kansas; Thomas F Tedder
Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(12):4094-102.
1991: Olivier Spertini; Francis W Luscinskas; Geoffrey S Kansas; J M Munro; James D Griffin; M A Gimbrone; Thomas F Tedder
Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(8):2565-73.
1991: Olivier Spertini; Geoffrey S Kansas; Keith A Reimann; CR Mackay; Thomas F Tedder
Function and evolutionary conservation of distinct epitopes on the leukocyte adhesion molecule-1 (TQ-1, Leu-8) that regulate leukocyte migration.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(3):942-9.
1991: Geoffrey S Kansas; Olivier Spertini; Lloyd M Stoolman; Thomas F Tedder
Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1.
The Journal of cell biology 1991;114(2):351-8.
1991: Geoffrey S Kansas; G S Wood; Thomas F Tedder
Expression, distribution, and biochemistry of human CD39. Role in activation-associated homotypic adhesion of lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2235-44.
1991: Olivier Spertini; Geoffrey S Kansas; J M Munro; James D Griffin; Thomas F Tedder
Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin.
Nature 1991;349(6311):691-4.