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Neil Kaplowitz
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28
Ookhtens, Murad
21
Fernández-Checa, José
21
Kuhlenkamp, John
16
García-Ruiz, Carmen
12
Colell, Anna
11
Lu, Shelly
10
Takikawa, Hajime
9
Kannan, Ram
7
Morales, Albert
7
Han, Derick
6
Liu, Zhang-Xu
5
Mittur, Aravind
4
Gunawan, Basuki
4
Ji, Cheng
4
Hanawa, Naoko
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All Publications
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2009: Verma S; Kaplowitz N
Diagnosis, management and prevention of drug-induced liver injury.
Gut 2009;58(11):1555-64.
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2009: Yuan Liyun; Kaplowitz Neil
Glutathione in liver diseases and hepatotoxicity.
Molecular aspects of medicine 2009;30(1-2):29-41.
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2008: Kaplowitz Neil; Shinohara Mie; Liu Zhang-Xu; Han Derick
How to protect against acetaminophen: don't ask for JUNK.
Gastroenterology 2008;135(4):1047-51.
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2008: Fallon Michael B; Krowka Michael J; Brown Robert S; Trotter James F; Zacks Steven; Roberts Kari E; Shah Vijay H; Kaplowitz Neil; Forman Lisa; Wille Keith; Kawut Steven M;
Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates.
Gastroenterology 2008;135(4):1168-75.
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2008: Kawut Steven M; Krowka Michael J; Trotter James F; Roberts Kari E; Benza Raymond L; Badesch David B; Taichman Darren B; Horn Evelyn M; Zacks Steven; Kaplowitz Neil; Brown Robert S; Fallon Michael B;
Clinical risk factors for portopulmonary hypertension.
Hepatology (Baltimore, Md.) 2008;48(1):196-203.
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2008: Saberi Behnam; Shinohara Mie; Ybanez Maria D; Hanawa Naoko; Gaarde William A; Kaplowitz Neil; Han Derick
Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes.
American journal of physiology. Cell physiology 2008;295(1):C50-63.
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2008: Ji Cheng; Shinohara Masao; Vance Dennis; Than Tin Aung; Ookhtens Murad; Chan Christine; Kaplowitz Neil
Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver.
Alcoholism, clinical and experimental research 2008;32(6):1049-58.
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2008: Hanawa Naoko; Shinohara Mie; Saberi Behnam; Gaarde William A; Han Derick; Kaplowitz Neil
Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury.
The Journal of biological chemistry 2008;283(20):13565-77.
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2007: Ji Cheng; Shinohara Masao; Kuhlenkamp John; Chan Christine; Kaplowitz Neil
Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes.
Hepatology (Baltimore, Md.) 2007;46(5):1586-96.
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2007: Lou Huan; Kaplowitz Neil
Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms.
The Journal of biological chemistry 2007;282(40):29470-81.
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2007: Gunawan Basuki K; Kaplowitz Neil
Mechanisms of drug-induced liver disease.
Clinics in liver disease 2007;11(3):459-75, v.
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2007: Abboud Gebran; Kaplowitz Neil
Drug-induced liver injury.
Drug safety : an international journal of medical toxicology and drug experience 2007;30(4):277-94.
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2006: Han Derick; Hanawa Naoko; Saberi Behnam; Kaplowitz Neil
Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis.
Free radical biology & medicine 2006;41(4):627-39.
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2006: Liu Zhang-Xu; Kaplowitz Neil
Role of innate immunity in acetaminophen-induced hepatotoxicity.
Expert opinion on drug metabolism & toxicology 2006;2(4):493-503.
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2006: Ji Cheng; Kaplowitz Neil
ER stress: can the liver cope?
Journal of hepatology 2006;45(2):321-33.
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2006: Gunawan Basuki K; Liu Zhang-Xu; Han Derick; Hanawa Naoko; Gaarde William A; Kaplowitz Neil
c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity.
Gastroenterology 2006;131(1):165-78.
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2006: Han Derick; Hanawa Naoko; Saberi Behnam; Kaplowitz Neil
Mechanisms of liver injury. III. Role of glutathione redox status in liver injury.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(1):G1-7.
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2006: Liu Zhang-Xu; Han Derick; Gunawan Basuki; Kaplowitz Neil
Neutrophil depletion protects against murine acetaminophen hepatotoxicity.
Hepatology (Baltimore, Md.) 2006;43(6):1220-30.
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2006: Nathwani Rahul A; Kaplowitz Neil
Drug hepatotoxicity.
Clinics in liver disease 2006;10(2):207-17, vii.
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2006: Kaplowitz Neil
Rules and laws of drug hepatotoxicity.
Pharmacoepidemiology and drug safety 2006;15(4):231-3.
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2005: Kaplowitz Neil
Idiosyncratic drug hepatotoxicity.
Nature reviews. Drug discovery 2005;4(6):489-99.
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2005: Fernandez-Checa Jose C; Kaplowitz Neil
Hepatic mitochondrial glutathione: transport and role in disease and toxicity.
Toxicology and applied pharmacology 2005;204(3):263-73.
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2005: Nathwani Rahul A; Kumar S Ram; Reynolds Telfer B; Kaplowitz Neil
Marked elevation in serum transaminases: an atypical presentation of choledocholithiasis.
The American journal of gastroenterology 2005;100(2):295-8.
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2005: Nathwani Rahul A; Pais Shireen; Reynolds Telfer B; Kaplowitz Neil
Serum alanine aminotransferase in skeletal muscle diseases.
Hepatology (Baltimore, Md.) 2005;41(2):380-2.
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2004: Liu Zhang-Xu; Govindarajan Sugantha; Kaplowitz Neil
Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity.
Gastroenterology 2004;127(6):1760-74.
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2004: Ji Cheng; Kaplowitz Neil
Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury.
World journal of gastroenterology : WJG 2004;10(12):1699-708.
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2004: Gunawan Basuki; Kaplowitz Neil
Clinical perspectives on xenobiotic-induced hepatotoxicity.
Drug metabolism reviews 2004;36(2):301-12.
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2004: Kaplowitz Neil
Drug-induced liver injury.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;38 Suppl 2():S44-8.
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2004: Han Derick; Matsumaru Katsu; Rettori Daniel; Kaplowitz Neil
Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress.
Biochemical pharmacology 2004;67(3):439-51.
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2003: Lou Huan; Ookhtens Murad; Stolz Andrew; Kaplowitz Neil
Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(6):G1335-44.
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2003: Han Derick; Canali Raffaella; Rettori Daniel; Kaplowitz Neil
Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria.
Molecular pharmacology 2003;64(5):1136-44.
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2003: Coll Olga; Colell Anna; García-Ruiz Carmen; Kaplowitz Neil; Fernández-Checa J C
Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion.
Hepatology (Baltimore, Md.) 2003;38(3):692-702.
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2003: Matsumaru Katsuhiko; Ji Cheng; Kaplowitz Neil
Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes.
Hepatology (Baltimore, Md.) 2003;37(6):1425-34.
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2003: Lluis Josep M; Colell Anna; García-Ruiz Carmen; Kaplowitz Neil; Fernández-Checa José C
Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress.
Gastroenterology 2003;124(3):708-24.
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2002: Liu Zhang-Xu; Kaplowitz Neil
Immune-mediated drug-induced liver disease.
Clinics in liver disease 2002;6(3):755-74.
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2002: Nagai Hidenari; Matsumaru Katsuhiko; Feng Guoping; Kaplowitz Neil
Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes.
Hepatology (Baltimore, Md.) 2002;36(1):55-64.
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2002: Feng Guoping; Kaplowitz Neil
Mechanism of staurosporine-induced apoptosis in murine hepatocytes.
American journal of physiology. Gastrointestinal and liver physiology 2002;282(5):G825-34.
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2002: Mittur Aravind; Wolkoff Allan W; Kaplowitz Neil
The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane.
Molecular pharmacology 2002;61(2):425-35.
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2001: Colell A; Coll O; García-Ruiz C; París R; Tiribelli C; Kaplowitz N; Fernández-Checa J C
Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione.
Hepatology (Baltimore, Md.) 2001;34(5):964-71.
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2001: Kannan R; Ouyang B; Wawrousek E; Kaplowitz N; Andley U P
Regulation of GSH in alphaA-expressing human lens epithelial cell lines and in alphaA knockout mouse lenses.
Investigative ophthalmology & visual science 2001;42(2):409-16.
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2001: Kaplowitz N
Drug-induced liver disorders: implications for drug development and regulation.
Drug safety : an international journal of medical toxicology and drug experience 2001;24(7):483-90.
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2000: Mittur A V; Kaplowitz N; Kempner E S; Ookhtens M
Radiation inactivation studies of hepatic sinusoidal reduced glutathione transport system.
Biochimica et biophysica acta 2000;1464(2):207-18.
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2000: Kaplowitz N
Cell death at the millennium. Implications for liver diseases.
Clinics in liver disease 2000;4(1):1-23, v.
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2000: Kannan R; Chakrabarti R; Tang D; Kim K J; Kaplowitz N
GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC.
Brain research 2000;852(2):374-82.
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2000: Kaplowitz N
Mechanisms of liver cell injury.
Journal of hepatology 2000;32(1 Suppl):39-47.
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1999: Kannan R; Mittur A; Bao Y; Tsuruo T; Kaplowitz N
GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodium-dependent GSH transporter.
Journal of neurochemistry 1999;73(1):390-9.
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1998: Colell A; García-Ruiz C; Miranda M; Ardite E; Marí M; Morales A; Corrales F; Kaplowitz N; Fernández-Checa J C
Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor.
Gastroenterology 1998;115(6):1541-51.
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1998: Kannan R; Bao Y; Mittur A; Andley U P; Kaplowitz N
Glutathione transport in immortalized HLE cells and expression of transport in HLE cell poly(A)+ RNA-injected Xenopus laevis oocytes.
Investigative ophthalmology & visual science 1998;39(8):1379-86.
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1998: Mittur A V; Kaplowitz N; Kempner E S; Ookhtens M
Novel properties of hepatic canalicular reduced glutathione transport revealed by radiation inactivation.
The American journal of physiology 1998;274(5 Pt 1):G923-30.
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1998: Huang Z Z; Li H; Cai J; Kuhlenkamp J; Kaplowitz N; Lu S C
Changes in glutathione homeostasis during liver regeneration in the rat.
Hepatology (Baltimore, Md.) 1998;27(1):147-53.
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1998: Fernández-Checa J C; Kaplowitz N; García-Ruiz C; Colell A
Mitochondrial glutathione: importance and transport.
Seminars in liver disease 1998;18(4):389-401.
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1998: Ookhtens M; Kaplowitz N
Role of the liver in interorgan homeostasis of glutathione and cyst(e)ine.
Seminars in liver disease 1998;18(4):313-29.
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1997: Colell A; García-Ruiz C; Morales A; Ballesta A; Ookhtens M; Rodés J; Kaplowitz N; Fernández-Checa J C
Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-L-methionine.
Hepatology (Baltimore, Md.) 1997;26(3):699-708.
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1997: Fernández-Checa J C; Kaplowitz N; García-Ruiz C; Colell A; Miranda M; Marí M; Ardite E; Morales A
GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect.
The American journal of physiology 1997;273(1 Pt 1):G7-17.
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1997: Lu S C; Kuhlenkamp J; Wu H; Sun W M; Stone L; Kaplowitz N
Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats.
The American journal of physiology 1997;272(2 Pt 1):G374-82.
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1997: Fernández-Checa J C; Kaplowitz N; Colell A; García-Ruiz C
Oxidative stress and alcoholic liver disease.
Alcohol health and research world 1997;21(4):321-4.
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1996: Kannan R; Yi J R; Tang D; Zlokovic B V; Kaplowitz N
Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium.
Investigative ophthalmology & visual science 1996;37(11):2269-75.
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1996: Lu S C; Cai J; Kuhlenkamp J; Sun W M; Takikawa H; Takenaka O; Horie T; Yi J; Kaplowitz N
Alterations in glutathione homeostasis in mutant Eisai hyperbilirubinemic rats.
Hepatology (Baltimore, Md.) 1996;24(1):253-8.
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1996: Fernández-Checa J C; García-Ruiz C; Colell A; Yi J R; Kaplowitz N
Inhibition of rat sinusoidal GSH transporter by thioethers: specificity, sidedness, and kinetics.
The American journal of physiology 1996;270(6 Pt 1):G969-75.
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1996: Takikawa H; Sugiyama Y; Fernandez-Checa J C; Kuhlenkamp J; Ookhtens M; Kaplowitz N
Evidence that interference with binding to hepatic cytosol binders can inhibit bile acid excretion in rats.
Hepatology (Baltimore, Md.) 1996;23(6):1642-9.
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1996: Kaplowitz N; Fernández-Checa J C; Kannan R; Garcia-Ruiz C; Ookhtens M; Yi J R
GSH transporters: molecular characterization and role in GSH homeostasis.
Biological chemistry Hoppe-Seyler 1996;377(5):267-73.
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1996: Fernández-Checa J C; Yi J R; García Ruiz C; Ookhtens M; Kaplowitz N
Plasma membrane and mitochondrial transport of hepatic reduced glutathione.
Seminars in liver disease 1996;16(2):147-58.
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1996: Kannan R; Yi J R; Tang D; Li Y; Zlokovic B V; Kaplowitz N
Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters.
The Journal of biological chemistry 1996;271(16):9754-8.
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1996: Lu S C; Sun W M; Yi J; Ookhtens M; Sze G; Kaplowitz N
Role of two recently cloned rat liver GSH transporters in the ubiquitous transport of GSH in mammalian cells.
The Journal of clinical investigation 1996;97(6):1488-96.
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1995: DeLeve L D; Kaplowitz N
Mechanisms of drug-induced liver disease.
Gastroenterology clinics of North America 1995;24(4):787-810.
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1995: García-Ruiz C; Colell A; Morales A; Kaplowitz N; Fernández-Checa J C
Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes.
Molecular pharmacology 1995;48(5):825-34.
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1995: Kannan R; Yi J R; Zlokovic B V; Kaplowitz N
Molecular characterization of a reduced glutathione transporter in the lens.
Investigative ophthalmology & visual science 1995;36(9):1785-92.
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1995: García-Ruiz C; Morales A; Colell A; Rodés J; Yi J R; Kaplowitz N; Fernández-Checa J C
Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione. Expression studies in Xenopus laevis oocytes.
The Journal of biological chemistry 1995;270(27):15946-9.
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1995: García-Ruiz C; Morales A; Colell A; Ballesta A; Rodés J; Kaplowitz N; Fernández-Checa J C
Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes.
Hepatology (Baltimore, Md.) 1995;21(1):207-14.
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1994: Lu S C; Kuhlenkamp J; Ge J L; Sun W M; Kaplowitz N
Specificity and directionality of thiol effects on sinusoidal glutathione transport in rat liver.
Molecular pharmacology 1994;46(3):578-85.
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1994: García-Ruiz C; Morales A; Ballesta A; Rodés J; Kaplowitz N; Fernández-Checa J C
Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes.
The Journal of clinical investigation 1994;94(1):193-201.
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1994: Yi J R; Lu S; Fernandez-Checa J; Kaplowitz N
Expression cloning of a rat hepatic reduced glutathione transporter with canalicular characteristics.
The Journal of clinical investigation 1994;93(4):1841-5.
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1994: Yamamuro W; Stolz A; Takikawa H; Sugimoto M; Kaplowitz N
Distribution of 3 alpha-hydroxysteroid dehydrogenase (bile acid binder) in rat small intestine: comparison with glutathione S-transferase subunits.
Journal of gastroenterology 1994;29(2):115-9.
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1993: Sze G; Kaplowitz N; Ookhtens M; Lu S C
Bidirectional membrane transport of intact glutathione in Hep G2 cells.
The American journal of physiology 1993;265(6 Pt 1):G1128-34.
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1993: Fernández-Checa J C; Hirano T; Tsukamoto H; Kaplowitz N
Mitochondrial glutathione depletion in alcoholic liver disease.
Alcohol (Fayetteville, N.Y.) 1993;10(6):469-75.
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1993: Kuhlenkamp J; Ronk M; Yusin M; Stolz A; Kaplowitz N
Identification and purification of a human liver cytosolic tocopherol binding protein.
Protein expression and purification 1993;4(5):382-9.
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1993: Lu S C; Ge J L; Huang H Y; Kuhlenkamp J; Kaplowitz N
Thiol-disulfide effects on hepatic glutathione transport. Studies in cultured rat hepatocytes and perfused livers.
The Journal of clinical investigation 1993;92(3):1188-97.
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1993: Fernández-Checa J C; Ookhtens M; Kaplowitz N
Selective induction by phenobarbital of the electrogenic transport of glutathione and organic anions in rat liver canalicular membrane vesicles.
The Journal of biological chemistry 1993;268(15):10836-41.
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1993: Fernández-Checa J C; Yi J R; Garcia-Ruiz C; Knezic Z; Tahara S M; Kaplowitz N
Expression of rat liver reduced glutathione transport in Xenopus laevis oocytes.
The Journal of biological chemistry 1993;268(4):2324-8.
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1992: Kannan R; Kuhlenkamp J F; Ookhtens M; Kaplowitz N
Transport of glutathione at blood-brain barrier of the rat: inhibition by glutathione analogs and age-dependence.
The Journal of pharmacology and experimental therapeutics 1992;263(3):964-70.
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1992: Hirano T; Kaplowitz N; Tsukamoto H; Kamimura S; Fernandez-Checa J C
Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats.
Hepatology (Baltimore, Md.) 1992;16(6):1423-7.
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1992: García-Ruiz C; Fernández-Checa J C; Kaplowitz N
Bidirectional mechanism of plasma membrane transport of reduced glutathione in intact rat hepatocytes and membrane vesicles.
The Journal of biological chemistry 1992;267(31):22256-64.
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1992: Lu S C; Ge J L; Kuhlenkamp J; Kaplowitz N
Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo.
The Journal of clinical investigation 1992;90(2):524-32.
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1992: Komatsu H; Koo A; Ghadishah E; Zeng H; Kuhlenkamp J F; Inoue M; Guth P H; Kaplowitz N
Neutrophil accumulation in ischemic reperfused rat liver: evidence for a role for superoxide free radicals.
The American journal of physiology 1992;262(4 Pt 1):G669-76.
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1992: Yoshida H; Yusin M; Ren I; Kuhlenkamp J; Hirano T; Stolz A; Kaplowitz N
Identification, purification, and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol.
Journal of lipid research 1992;33(3):343-50.
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1992: Koo A; Komatsu H; Tao G; Inoue M; Guth P H; Kaplowitz N
Contribution of no-reflow phenomenon to hepatic injury after ischemia-reperfusion: evidence for a role for superoxide anion.
Hepatology (Baltimore, Md.) 1992;15(3):507-14.
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1992: Fernández-Checa J C; Takikawa H; Horie T; Ookhtens M; Kaplowitz N
Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats.
The Journal of biological chemistry 1992;267(3):1667-73.
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1992: Saiki H; Chan E T; Wong E; Yamamuro W; Ookhtens M; Kaplowitz N
Zonal distribution of cysteine uptake in the perfused rat liver.
The Journal of biological chemistry 1992;267(1):192-6.
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1991: DeLeve L D; Kaplowitz N
Glutathione metabolism and its role in hepatotoxicity.
Pharmacology & therapeutics 1991;52(3):287-305.
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1991: Takikawa H; Fernandez-Checa J C; Kuhlenkamp J; Stolz A; Ookhtens M; Kaplowitz N
Effect of indomethacin on the uptake, metabolism and excretion of 3-oxocholic acid: studies in isolated hepatocytes and perfused rat liver.
Biochimica et biophysica acta 1991;1084(3):247-50.
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1991: Lu S C; Kuhlenkamp J; Garcia-Ruiz C; Kaplowitz N
Hormone-mediated down-regulation of hepatic glutathione synthesis in the rat.
The Journal of clinical investigation 1991;88(1):260-9.
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1991: Fernández-Checa J C; García-Ruiz C; Ookhtens M; Kaplowitz N
Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress.
The Journal of clinical investigation 1991;87(2):397-405.
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1990: DeLeve L D; Kaplowitz N
Importance and regulation of hepatic glutathione.
Seminars in liver disease 1990;10(4):251-66.
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1990: Lu S C; Garcia-Ruiz C; Kuhlenkamp J; Ookhtens M; Salas-Prato M; Kaplowitz N
Hormonal regulation of glutathione efflux.
The Journal of biological chemistry 1990;265(27):16088-95.
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1990: Fernandez-Checa J C; Maddatu T; Ookhtens M; Kaplowitz N
Inhibition of GSH efflux from rat liver by methionine: effects of GSH synthesis in cells and perfused organ.
The American journal of physiology 1990;258(6 Pt 1):G967-73.
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1990: Kannan R; Kuhlenkamp J F; Jeandidier E; Trinh H; Ookhtens M; Kaplowitz N
Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat.
The Journal of clinical investigation 1990;85(6):2009-13.
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1990: Takikawa H; Stolz A; Sugiyama Y; Yoshida H; Yamanaka M; Kaplowitz N
Relationship between the newly identified bile acid binder and bile acid oxidoreductases in human liver.
The Journal of biological chemistry 1990;265(4):2132-6.
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1989: Fernandez-Checa J C; Ookhtens M; Kaplowitz N
Effects of chronic ethanol feeding on rat hepatocytic glutathione. Relationship of cytosolic glutathione to efflux and mitochondrial sequestration.
The Journal of clinical investigation 1989;83(4):1247-52.
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1989: Lu S C; Kuhlenkamp J; Robert A; Kaplowitz N
Role of glutathione status in protection against ethanol-induced gastric lesions.
Pharmacology 1989;38(1):57-60.
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1989: Stolz A; Takikawa H; Ookhtens M; Kaplowitz N
The role of cytoplasmic proteins in hepatic bile acid transport.
Annual review of physiology 1989;51():161-76.
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1988: Fernandez-Checa J C; Ren C; Aw T Y; Ookhtens M; Kaplowitz N
Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes.
The American journal of physiology 1988;255(4 Pt 1):G403-8.
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1988: Ookhtens M; Lyon I; Fernandez-Checa J; Kaplowitz N
Inhibition of glutathione efflux in the perfused rat liver and isolated hepatocytes by organic anions and bilirubin. Kinetics, sidedness, and molecular forms.
The Journal of clinical investigation 1988;82(2):608-16.
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1988: Takikawa H; Sugiyama Y; Kaplowitz N
Comparison of the effects of bile acids and GSH on the fluorescence of bound 1-anilino-8-naphthalene sulfonate and the enzymatic activity of cationic and neutral human hepatic GSH S-transferases.
Biochimica et biophysica acta 1988;954(1):37-43.
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1988: Takikawa H; Kaplowitz N
Comparison of the binding sites of GSH S-transferases of the Ya- and Yb-subunit classes: effect of glutathione on the binding of bile acids.
Journal of lipid research 1988;29(3):279-86.
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1987: Ookhtens M; Lyon I; Kaplowitz N
Effect of age on the sinusoidal release of hepatic glutathione from the perfused rat liver.
Biochemical pharmacology 1987;36(22):4015-7.
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1987: Takikawa H; Ookhtens M; Stolz A; Kaplowitz N
Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by 3 alpha-hydroxysteroid dehydrogenase. II. Studies in the prograde and retrograde single-pass, perfused rat liver and inhibition by indomethacin.
The Journal of clinical investigation 1987;80(3):861-6.
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1987: Fernandez-Checa J C; Ookhtens M; Kaplowitz N
Effect of chronic ethanol feeding on rat hepatocytic glutathione. Compartmentation, efflux, and response to incubation with ethanol.
The Journal of clinical investigation 1987;80(1):57-62.
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1987: Stolz A; Takikawa H; Sugiyama Y; Kuhlenkamp J; Kaplowitz N
3 alpha-hydroxysteroid dehydrogenase activity of the Y' bile acid binders in rat liver cytosol. Identification, kinetics, and physiologic significance.
The Journal of clinical investigation 1987;79(2):427-34.
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1986: Aw T Y; Ookhtens M; Kaplowitz N
Mechanism of inhibition of glutathione efflux by methionine from isolated rat hepatocytes.
The American journal of physiology 1986;251(3 Pt 1):G354-61.
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1986: Stolz A; Sugiyama Y; Kuhlenkamp J; Osadchey B; Yamada T; Belknap W; Balistreri W; Kaplowitz N
Cytosolic bile acid binding protein in rat liver: radioimmunoassay, molecular forms, developmental characteristics and organ distribution.
Hepatology (Baltimore, Md.) 1986;6(3):433-9.
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1986: Aw T Y; Ookhtens M; Ren C; Kaplowitz N
Kinetics of glutathione efflux from isolated rat hepatocytes.
The American journal of physiology 1986;250(2 Pt 1):G236-43.
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1985: Sugimoto M; Kuhlenkamp J; Ookhtens M; Aw T Y; Reeve J; Kaplowitz N
Gamma-glutamylcysteine: a substrate for glutathione S-transferases.
Biochemical pharmacology 1985;34(20):3643-7.
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1984: Stolz A; Sugiyama Y; Kuhlenkamp J; Kaplowitz N
Identification and purification of a 36 kDa bile acid binder in human hepatic cytosol.
FEBS letters 1984;177(1):31-5.
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1984: Stolz A; Yamada T; Sugiyama Y; Belknap W; Kaplowitz N
Quantitation and characterization of a newly described organic anion binder by radioimmunoassay.
Biochimica et biophysica acta 1984;800(2):171-7.
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