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Reuben Kapur

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S C Nabinger; B Ramdas; B Richine; G E Sandusky; M Yu; L Zeng; X Zhang; Z-Y Zhang; G-S Feng; Seiji Fukuda; Shreevrat Goenka; Y He; Reuben Kapur; X J Li; Z Liu; H Scott Boswell; J D Bowling; Rebecca J Chan
The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.
Jianjian Shi; Michelle Surma; Sasidhar Vemula; Xiangbing Wu; Yu Yang; Lumin Zhang; Reuben Kapur; Lei Wei
Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment.
Raghuveer Singh Mali; Reuben Kapur
Unique and redundant roles of class IA PI3Kinase regulatory subunits in mast cell development.

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All Publications

2013: S C Nabinger; B Ramdas; B Richine; G E Sandusky; M Yu; L Zeng; X Zhang; Z-Y Zhang; G-S Feng; Seiji Fukuda; Shreevrat Goenka; Y He; Reuben Kapur; X J Li; Z Liu; H Scott Boswell; J D Bowling; Rebecca J Chan
The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.
Leukemia 2013;27(2):398-408.
2013: Jianjian Shi; Michelle Surma; Sasidhar Vemula; Xiangbing Wu; Yu Yang; Lumin Zhang; Reuben Kapur; Lei Wei
Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment.
Cell death & disease 2013;4():e483.
2013: Raghuveer Singh Mali; Reuben Kapur
Unique and redundant roles of class IA PI3Kinase regulatory subunits in mast cell development.
Cell cycle (Georgetown, Tex.) 2013;12(1):7-8.
2012: Sasidhar Vemula; Lei Wei; Philip Hanneman; Eri Hashino; Karl R Koehler; Yan Liu; Peilin Ma; Raghuveer S Mali; Jianjian Shi; Reuben Kapur
ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53.
Blood 2012;120(14):2868-78.
2012: Raghuveer S Mali; Rebecca Chan; Reuben Kapur
Targeting SHP2 phosphatase in myeloproliferative neoplasms.
Oncotarget 2012;3(10):1049-51.
2012: Raghuveer S Mali; Holly Martin; Veerendra Munugalavadla; Sarah Nabinger; Baskar Ramdas; George Sandusky; Namit Sharma; Emily Sims; Li-Fan Zeng; Zhong-Yin Zhang; Kevin D Bunting; Rebecca J Chan; Anindya Chatterjee; Andrew W B Craig; Gen-Sheng Feng; Joydeep Ghosh; Yantao He; Shuo Li; Peilin Ma; Reuben Kapur
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.
Blood 2012;120(13):2669-78.
2012: Raghuveer Singh Mali; Reuben Kapur
Targeting Rho associated kinases in leukemia and myeloproliferative neoplasms.
Oncotarget 2012;3(9):909-10.
2012: Richard M Gallo; Reuben Kapur; Masood A Khan; Jianyun Liu; Jianjian Shi; Lei Wei; Jennifer C Bailey; Randy R Brutkiewicz
Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(4):1689-98.
2012: P Ma; Raghuveer S Mali; H Martin; B Ramdas; E Sims; Reuben Kapur
Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease.
Leukemia 2012;26(7):1499-506.
2012: Subha Krishnan; Peilin Ma; Raghuveer S Mali; Veerendra Munugalavadla; Baskar Ramdas; Emily Sims; Joal D Beane; Joydeep Ghosh; Philip Hanneman; Reuben Kapur
p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis.
Blood 2012;119(17):3951-61.
2012: Fabiola Traina; Valeria Visconte; Anjali S Advani; Edward Copelan; Hien K Duong; Paul Elson; Yingchun Han; Fred H Hsieh; Anna Jankowska; Matt Kalaycio; Reuben Kapur; Alan E Lichtin; Jaroslaw P Maciejewski; Hideki Makishima; Raghuveer Singh Mali; Christine L O'Keefe; Sara T Olalla Saad; Mikkael A Sekeres; Ramon Tiu
Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis.
PloS one 2012;7(8):e43090.
2011: Peng Qu; Cong Yan; Janice S Blum; Reuben Kapur; Hong Du
Myeloid-specific expression of human lysosomal acid lipase corrects malformation and malfunction of myeloid-derived suppressor cells in lal-/- mice.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(7):3854-66.
2011: Peilin Ma; Raghuveer Singh Mali; Veerendra Munugalavadla; Baskar Ramdas; Emily Sims; Clifford M Takemoto; Sasidhar Vemula; Jovencio Borneo; Jinbiao Chen; Eri Hashino; Takako Kondo; Shuo Li; Reuben Kapur
Balanced interactions between Lyn, the p85alpha regulatory subunit of class I(A) phosphatidylinositol-3-kinase, and SHIP are essential for mast cell growth and maturation.
Molecular and cellular biology 2011;31(19):4052-62.
2011: Peilin Ma; Raghuveer Singh Mali; Holly Martin; Veerendra Munugalavadla; Baskar Ramdas; Emily Sims; Clifford M Takemoto; Rebecca J Chan; Andrew W Craig; Joydeep Ghosh; Subha Krishnan; Gerald Krystal; Shuo Li; Reuben Kapur
The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor.
Blood 2011;118(13):3459-69.
2011: Raghuveer Singh Mali; Veerendra Munugalavadla; Sarah C Nabinger; Baskar Ramdas; Jianjian Shi; Emily Sims; Andrew M Stern; Ramon V Tiu; Fabiola Traina; Sasidhar Vemula; Valeria Visconte; Lei Wei; Qiang Wen; H Scott Boswell; Rebecca J Chan; John D Crispino; Charles B Goodwin; Timothy A Lewis; Peilin Ma; Reuben Kapur
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell 2011;20(3):357-69.
2011: Xiaohua Wu; Shi Chen; Selina A Orlando; Jin Yuan; Edward T Kim; Veerendra Munugalavadla; Raghuveer S Mali; Reuben Kapur; Feng-Chun Yang
p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway.
The Journal of biological chemistry 2011;286(15):13512-21.
2010: Sasidhar Vemula; Baskar Ramdas; Philip Hanneman; Joseph Martin; Hilary E Beggs; Reuben Kapur
Essential role for focal adhesion kinase in regulating stress hematopoiesis.
Blood 2010;116(20):4103-15.
2010: Sasidhar Vemula; Jianjian Shi; Philip Hanneman; Lei Wei; Reuben Kapur
ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.
Blood 2010;115(9):1785-96.
2010: Eric A Benson; Mark G Goebl; Feng-Chun Yang; Reuben Kapur; Jeanette McClintick; Sonal Sanghani; D Wade Clapp; Maureen A Harrington
Loss of SIMPL compromises TNF-alpha-dependent survival of hematopoietic progenitors.
Experimental hematology 2010;38(2):71-81.
2009: M Reza Saadatzadeh; Khadijeh Bijangi-Vishehsaraei; Reuben Kapur; Laura S Haneline
Distinct roles of stress-activated protein kinases in Fanconi anemia-type C-deficient hematopoiesis.
Blood 2009;113(12):2655-60.
2008: Veerendra Munugalavadla; Sasidhar Vemula; Emily Catherine Sims; Subha Krishnan; Shi Chen; Jincheng Yan; Huijie Li; Paul J Niziolek; Clifford M Takemoto; Alexander G Robling; Feng-Chun Yang; Reuben Kapur
The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration.
Molecular and cellular biology 2008;28(23):7182-98.
2008: Li Hong; Baskar Ramdas; Jinbiao Chen; Chad Harris; Don M Wojchowski; Reuben Kapur
KIT associated intracellular tyrosines play an essential role in EpoR co-signaling.
Cellular signalling 2008;20(8):1513-20.
2008: Christie M Orschell; Jovencio Borneo; Veerendra Munugalavadla; Peilin Ma; Emily Sims; Baskar Ramdas; Mervin C Yoder; Reuben Kapur
Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells.
Experimental hematology 2008;36(5):655-66.
2008: Jincheng Yan; Shi Chen; Yingze Zhang; Xiaohong Li; Yan Li; Xiaohua Wu; Jin Yuan; Alexander G Robling; Reuben Kapur; Reuben Karpur; Rebecca J Chan; Feng-Chun Yang
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
Human molecular genetics 2008;17(7):936-48.
2008: Veerendra Munugalavadla; Emily C Sims; Rebecca J Chan; Stephen D Lenz; Reuben Kapur
Requirement for p85alpha regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT.
Experimental hematology 2008;36(3):301-8.
2007: Veerendra Munugalavadla; Emily C Sims; Jovencio Borneo; Rebecca J Chan; Reuben Kapur
Genetic and pharmacologic evidence implicating the p85 alpha, but not p85 beta, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis.
Blood 2007;110(5):1612-20.
2007: Jovencio Borneo; Veerendra Munugalavadla; Emily C Sims; Sasidhar Vemula; Christie M Orschell; Merv Yoder; Reuben Kapur
Src family kinase-mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors.
Experimental hematology 2007;35(7):1026-37.
2007: Anubhav N Mathur; Hua-Chen Chang; Dimitrios G Zisoulis; Gretta L Stritesky; Qing Yu; John T O'Malley; Reuben Kapur; David E Levy; Geoffrey S Kansas; Mark H Kaplan
Stat3 and Stat4 direct development of IL-17-secreting Th cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4901-7.
2006: Xiaohua Wu; Selina A Estwick; Shi Chen; Menggang Yu; Wenyu Ming; Todd D Nebesio; Yan Li; Jin Yuan; Reuben Kapur; David Ingram; Mervin C Yoder; Feng-Chun Yang
Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells.
Human molecular genetics 2006;15(19):2837-45.
2006: Anubhav N Mathur; Hua-Chen Chang; Dimitrios G Zisoulis; Reuben Kapur; Maria Laura Belladonna; Geoffrey S Kansas; Mark H Kaplan
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.
Blood 2006;108(5):1595-601.
2006: Binghui Li; Nan Jia; Reuben Kapur; Kristin T Chun
Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis.
Blood 2006;107(11):4291-9.
2006: Laura S Haneline; Hilary White; Feng-Chun Yang; Shi Chen; Christie M Orschell; Reuben Kapur; David A Ingram
Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo.
Blood 2006;107(4):1375-82.
2006: Zheng-Yu Wang; Saritha Kusam; Veerendra Munugalavadla; Reuben Kapur; Randy R Brutkiewicz; Alexander L Dent
Regulation of Th2 cytokine expression in NKT cells: unconventional use of Stat6, GATA-3, and NFAT2.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(2):880-8.
2005: Khadijeh Bijangi-Vishehsaraei; M Reza Saadatzadeh; Adam Werne; Kristina A Wilson McKenzie; Reuben Kapur; Hidenori Ichijo; Laura S Haneline
Enhanced TNF-alpha-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1.
Blood 2005;106(13):4124-30.
2005: Veerendra Munugalavadla; Lou Dore; Bai Lin Tan; Li Hong; Melanie Vishnu; Mitchell J Weiss; Reuben Kapur
Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation.
Molecular and cellular biology 2005;25(15):6747-59.
2005: Veerendra Munugalavadla; Jovencio Borneo; David A Ingram; Reuben Kapur
p85alpha subunit of class IA PI-3 kinase is crucial for macrophage growth and migration.
Blood 2005;106(1):103-9.
2005: Waleed Khalaf; Hilary White; Mary Jo Wenning; Attilio Orazi; Reuben Kapur; David A Ingram
K-Ras is essential for normal fetal liver erythropoiesis.
Blood 2005;105(9):3538-41.
2005: Rebecca J Chan; Melissa B Leedy; Veerendra Munugalavadla; Cara S Voorhorst; Yanjun Li; Menggang Yu; Reuben Kapur
Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor.
Blood 2005;105(9):3737-42.
2005: Veerendra Munugalavadla; Reuben Kapur
Role of c-Kit and erythropoietin receptor in erythropoiesis.
Critical reviews in oncology/hematology 2005;54(1):63-75.
2004: Kelly K Hiatt; David A Ingram; Hannah Huddleston; Dan F Spandau; Reuben Kapur; D Wade Clapp
Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells.
The American journal of pathology 2004;164(4):1471-9.
2004: Li Hong; Veerendra Munugalavadla; Reuben Kapur
c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways.
Molecular and cellular biology 2004;24(3):1401-10.
2003: Feng-Chun Yang; David A Ingram; Shi Chen; Cynthia M Hingtgen; Nancy Ratner; Kelly R Monk; Travis Clegg; Hilary White; Laura E Mead; Mary Jo Wenning; David A Williams; Reuben Kapur; Simon J Atkinson; D Wade Clapp
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.
The Journal of clinical investigation 2003;112(12):1851-61.
2003: Hannah Huddleston; Bailin Tan; Feng-Chun Yang; Hilary White; Mary Jo Wenning; Attilio Orazi; Mervin C Yoder; Reuben Kapur; David A Ingram
Functional p85alpha gene is required for normal murine fetal erythropoiesis.
Blood 2003;102(1):142-5.
2003: Bai Lin Tan; Mustafa Yazicioglu; David Ingram; Jennifer McCarthy; Jovencio Borneo; David A Williams; Reuben Kapur
Genetic evidence for convergence of c-Kit- and alpha4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells.
Blood 2003;101(12):4725-32.
2003: Bai Lin Tan; Li Hong; Veerendra Munugalavadla; Reuben Kapur
Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit. Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor.
The Journal of biological chemistry 2003;278(13):11686-95.
2003: Xiaodong Xie; Rebecca J Chan; Scott A Johnson; Mark Starr; Jennifer McCarthy; Reuben Kapur; Mervin C Yoder
Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs.
Blood 2003;101(4):1329-35.
2002: David A Ingram; Lei Zhang; Jennifer McCarthy; Mary Jo Wenning; Lucy Fisher; Feng-Chun Yang; D Wade Clapp; Reuben Kapur
Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences of Nf1 deficiency in T-cell development and function.
Blood 2002;100(10):3656-62.
2002: Reuben Kapur; Saurabh Chandra; Ryan Cooper; Jennifer McCarthy; David A Williams
Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor.
Blood 2002;100(4):1287-93.
2002: Silvio A Marques; Lady C Dy; Michael D Southall; Qiaofang Yi; Eva Smietana; Reuben Kapur; Mariangela Marques; Jeffrey B Travers; Dan F Spandau
The platelet-activating factor receptor activates the extracellular signal-regulated kinase mitogen-activated protein kinase and induces proliferation of epidermal cells through an epidermal growth factor-receptor-dependent pathway.
The Journal of pharmacology and experimental therapeutics 2002;300(3):1026-35.
2001: Reuben Kapur; L Zhang
A novel mechanism of cooperation between c-Kit and erythropoietin receptor. Stem cell factor induces the expression of Stat5 and erythropoietin receptor, resulting in efficient proliferation and survival by erythropoietin.
The Journal of biological chemistry 2001;276(2):1099-106.
2000: Feng-Chun Yang; Reuben Kapur; AJ King; W Tao; Chaekyun Kim; Jovencio Borneo; Robert Breese; M Marshall; Mary C Dinauer; David A Williams
Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells.
Immunity 2000;12(5):557-68.
1999: Andrew W Roberts; Chaekyun Kim; Lijie Zhen; J B Lowe; Reuben Kapur; B Petryniak; A Spaetti; Jonathan D Pollock; Jovencio Borneo; G B Bradford; Simon J Atkinson; Mary C Dinauer; David A Williams
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense.
Immunity 1999;10(2):183-96.
1998: Reuben Kapur; Manas Majumdar; X Xiao; M McAndrews-Hill; K Schindler; David A Williams
Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor tyrosine kinase: genetic evidence for a differential role in erythropoiesis.
Blood 1998;91(3):879-89.
1997: Reuben Kapur; Eric Everett; J Uffman; M McAndrews-Hill; Ryan Cooper; J Ryder; TA Vik; David A Williams
Overexpression of human stem cell factor impairs melanocyte, mast cell, and thymocyte development: a role for receptor tyrosine kinase-mediated mitogen activated protein kinase activation in cell differentiation.
Blood 1997;90(8):3018-26.
1997: R Maze; Reuben Kapur; Mark R Kelley; WK Hansen; S Y Oh; David A Williams
Reversal of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced severe immunodeficiency by transduction of murine long-lived hemopoietic progenitor cells using O6-methylguanine DNA methyltransferase complementary DNA.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):1006-13.
1996: Manas Majumdar; Eric Everett; X Xiao; R Cooper; K Langley; Reuben Kapur; TA Vik; David A Williams
Xenogeneic expression of human stem cell factor in transgenic mice mimics codominant c-kit mutations.
Blood 1996;87(8):3203-11.