Hideaki Karaki

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Murata Takahisa; Kinoshita Kazuya; Hori Masatoshi; Kuwahara Masayoshi; Tsubone Hirokazu; Karaki Hideaki; Ozaki Hiroshi
Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension.
Murata Takahisa; Hori Masatoshi; Lee Sheng; Nakamura Akio; Kohama Kazuhiro; Karaki Hideaki; Ozaki Hiroshi
Vascular endothelium has a local anti-adenovirus vector system and glucocorticoid optimizes its gene transduction.
Murata Takahisa; Suzuki Natsuko; Yamawaki Hideyuki; Sato Koichi; Hori Masatoshi; Karaki Hideaki; Ozaki Hiroshi
Dexamethasone prevents impairment of endothelium-dependent relaxation in arteries cultured with fetal bovine serum.

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All Publications

2005: Murata Takahisa; Kinoshita Kazuya; Hori Masatoshi; Kuwahara Masayoshi; Tsubone Hirokazu; Karaki Hideaki; Ozaki Hiroshi
Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(11):2335-42.
2005: Murata Takahisa; Hori Masatoshi; Lee Sheng; Nakamura Akio; Kohama Kazuhiro; Karaki Hideaki; Ozaki Hiroshi
Vascular endothelium has a local anti-adenovirus vector system and glucocorticoid optimizes its gene transduction.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(9):1796-803.
2005: Murata Takahisa; Suzuki Natsuko; Yamawaki Hideyuki; Sato Koichi; Hori Masatoshi; Karaki Hideaki; Ozaki Hiroshi
Dexamethasone prevents impairment of endothelium-dependent relaxation in arteries cultured with fetal bovine serum.
European journal of pharmacology 2005;515(1-3):134-41.
2004: Murata Takahisa; Hori Masatoshi; Sakamoto Kenichi; Karaki Hideaki; Ozaki Hiroshi
Dexamethasone blocks hypoxia-induced endothelial dysfunction in organ-cultured pulmonary arteries.
American journal of respiratory and critical care medicine 2004;170(6):647-55.
2004: Karaki Hideaki
Historical techniques: cytosolic Ca2+ and contraction in smooth muscle.
Trends in pharmacological sciences 2004;25(7):388-93.
2004: Katayama Hideo; Hori Masatoshi; Sato Koichi; Kajita Masahiro; Ozaki Hiroshi; Karaki Hideaki; Ohashi Kenjiro; Kai Chieko
Role of actin microfilaments in canine distemper virus replication in vero cells.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2004;66(4):409-15.
2004: Ozaki Hiroshi; Hori Masatoshi; Takeo Jiro; Hata Jun-Ichiro; Jinno Shuji; Okita Takaaki; Yamashita Shinya; Karaki Hideaki
Mechanisms responsible for the in vitro relaxation of a novel dibenzothiepine derivative (NSU-242) on tracheal and vascular smooth muscles.
European journal of pharmacology 2004;488(1-3):191-9.
2004: Ozaki H; Kawai T; Shuttleworth C W; Won K-J; Suzuki T; Sato K; Horiguchi H; Hori M; Karaki H; Torihashi S; Ward S M; Sanders K M
Isolation and characterization of resident macrophages from the smooth muscle layers of murine small intestine.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2004;16(1):39-51.
2004: Oka Tatsuya; Hori Masatoshi; Tanaka Akane; Matsuda Hiroshi; Karaki Hideaki; Ozaki Hiroshi
IgE alone-induced actin assembly modifies calcium signaling and degranulation in RBL-2H3 mast cells.
American journal of physiology. Cell physiology 2004;286(2):C256-63.
2003: Ozaki Hiroshi; Yasuda Katsuhiko; Kim Yoon-Sun; Egawa Makoto; Kanzaki Hideharu; Nakazawa Hiroshi; Hori Masatoshi; Seto Minoru; Karaki Hideaki
Possible role of the protein kinase C/CPI-17 pathway in the augmented contraction of human myometrium after gestation.
British journal of pharmacology 2003;140(7):1303-12.
2003: Ohama Takashi; Hori Masatoshi; Sato Koichi; Ozaki Hiroshi; Karaki Hideaki
Chronic treatment with interleukin-1beta attenuates contractions by decreasing the activities of CPI-17 and MYPT-1 in intestinal smooth muscle.
The Journal of biological chemistry 2003;278(49):48794-804.
2003: Kim Yoon-Sun; Kim Bokyung; Karaki Hideaki; Hori Masatoshi; Ozaki Hiroshi
Up-regulation of Rnd1 during pregnancy serves as a negative-feedback control for Ca2+ sensitization of contractile elements in rat myometrium.
Biochemical and biophysical research communications 2003;311(4):972-8.
2003: Kinoshita Kazuya; Sato Koichi; Hori Masatoshi; Ozaki Hiroshi; Karaki Hideaki
Decrease in activity of smooth muscle L-type Ca2+ channels and its reversal by NF-kappaB inhibitors in Crohn's colitis model.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(3):G483-93.
2003: Nagasaka Tsuyoshi; Izumi Masanori; Hori Masatoshi; Ozaki Hiroshi; Karaki Hideaki
Positive inotropic effect of endothelin-1 in the neonatal mouse right ventricle.
European journal of pharmacology 2003;472(3):197-204.
2003: Sakamoto Kazuyuki; Hori Masatoshi; Izumi Masanori; Oka Tatsuya; Kohama Kazuhiro; Ozaki Hiroshi; Karaki Hideaki
Inhibition of high K+-induced contraction by the ROCKs inhibitor Y-27632 in vascular smooth muscle: possible involvement of ROCKs in a signal transduction pathway.
Journal of pharmacological sciences 2003;92(1):56-69.
2003: Kim Bokyung; Kim Yoon-Sun; Ahn Jiyun; Kim Junghwan; Cho SungIl; Won Kyung-Jong; Ozaki Hiroshi; Karaki Hideaki; Lee Sang-Mok
Conventional-type protein kinase C contributes to phorbol ester-induced inhibition of rat myometrial tension.
British journal of pharmacology 2003;139(2):408-14.
2003: Tsutsui Shigeki; Itagaki Shin-ichi; Kawamura Seiji; Harada Ken-ichi; Karaki Hideaki; Doi Kunio; Yoshikawa Yasuhiro
D-galactosamine induced hepatocyte apoptosis is inhibited in vivo and in cell culture by a calcium calmodulin antagonist, chlorpromazine, and a calcium channel blocker, verapamil.
Experimental animals / Japanese Association for Laboratory Animal Science 2003;52(1):43-52.
2003: Bannai Makoto; Yoshimoto Ryo; MiTSUI-SAITO Minori; Hori Masatoshi; Nishihara Masugi; Takahashi Katsuhito; Yamamura Hisako; Taniguchi Shun'ichiro; Katsuki Motoya; Ozaki Hiroshi; Karaki Hideaki
Increased locomotor activity, increased food and water intake and decreased PVN neurons in H1 calponin gene-deficient mice.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2003;65(1):153-5.
2002: Ozaki Hiroshi; Hori Masatoshi; Kim Yoon-Sun; Kwon Seong-Chun; Ahn Duck-Sun; Nakazawa Hiroshi; Kobayashi Motomasa; Karaki Hideaki
Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle.
British journal of pharmacology 2002;137(8):1207-12.
2002: Murata Takahisa; Sato Koichi; Hori Masatoshi; Ozaki Hiroshi; Karaki Hideaki
Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension.
The Journal of biological chemistry 2002;277(46):44085-92.
2002: Oka Tatsuya; Sato Koichi; Hori Masatoshi; Ozaki Hiroshi; Karaki Hideaki
FcepsilonRI cross-linking-induced actin assembly mediates calcium signalling in RBL-2H3 mast cells.
British journal of pharmacology 2002;136(6):837-46.
2002: Ozaki Hiroshi; Karaki Hideaki
Organ culture as a useful method for studying the biology of blood vessels and other smooth muscle tissues.
Japanese journal of pharmacology 2002;89(2):93-100.
2002: Oka Tatsuya; Sato Koichi; Hori Masatoshi; Ozaki Hiroshi; Karaki Hideaki
Xestospongin C, a novel blocker of IP3 receptor, attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL-2H3 mast cells.
British journal of pharmacology 2002;135(8):1959-66.
2002: Won K-J; Torihashi S; Mitsui-Saito M; Hori M; Sato K; Suzuki T; Ozaki H; Karaki H
Increased smooth muscle contractility of intestine in the genetic null of the endothelin ETB receptor: a rat model for long segment Hirschsprung's disease.
Gut 2002;50(3):355-60.
2001: Murata T; Yamawaki H; Yoshimoto R; Hori M; Sato K; Ozaki H; Karaki H
Chronic effect of doxorubicin on vascular endothelium assessed by organ culture study.
Life sciences 2001;69(22):2685-95.
2001: Nakazawa H; Hori M; Murata T; Ozaki H; Karaki H
Contribution of chloride channel activation to the elevated muscular tone of the pulmonary artery in monocrotaline-induced pulmonary hypertensive rats.
Japanese journal of pharmacology 2001;86(3):310-5.
2001: Murata T; Yamawaki H; Hori M; Sato K; Ozaki H; Karaki H
Hypoxia impairs endothelium-dependent relaxation in organ cultured pulmonary artery.
European journal of pharmacology 2001;421(1):45-53.
2001: Hori M; Kita M; Torihashi S; Miyamoto S; Won K J; Sato K; Ozaki H; Karaki H
Upregulation of iNOS by COX-2 in muscularis resident macrophage of rat intestine stimulated with LPS.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(5):G930-8.
2001: Murata T; Yamawaki H; Hori M; Sato K; Ozaki H; Karaki H
Chronic vascular toxicity of doxorubicin in an organ-cultured artery.
British journal of pharmacology 2001;132(7):1365-73.
2001: Sato K; Horibe K; Amano K; Mitusi-Saito M; Hori M; Matsunaga S; Fusetani N; Ozaki H; Karaki H
Membrane permeabilization induced by discodermin A, a novel marine bioactive peptide.
Toxicon : official journal of the International Society on Toxinology 2001;39(2-3):259-64.
2001: Miyamoto S; Hori M; Izumi M; Ozaki H; Karaki H
Species- and temperature-dependency of the decrease in myofilament Ca2+ sensitivity induced by beta-adrenergic stimulation.
Japanese journal of pharmacology 2001;85(1):75-83.
2000: Anabuki J; Hori M; Hayakawa K; Akahane S; Ozaki H; Karaki H
Muscarinic stimulation does not induce rhoA/ROCK-mediated Ca2+ sensitization of the contractile element in chicken gizzard smooth muscle.
Pflügers Archiv : European journal of physiology 2000;441(2-3):189-99.
2000: Yoshimoto R; Hori M; Takahashi K; Taniguchi S I; Katsuki M; Ozaki H; Karaki H
Ca2+-Sensitization of contraction in the h1 calponin-deficient smooth muscle.
Japanese journal of pharmacology 2000;84(4):474-5.
2000: Yamawaki H; Sato K; Hori M; Ozaki H; Karaki H
Platelet-derived growth factor causes endothelium-independent relaxation of rabbit mesenteric artery via the release of a prostanoid.
British journal of pharmacology 2000;131(8):1546-52.
2000: Takahashi K; Yoshimoto R; Fuchibe K; Fujishige A; Mitsui-Saito M; Hori M; Ozaki H; Yamamura H; Awata N; Taniguchi S; Katsuki M; Tsuchiya T; Karaki H
Regulation of shortening velocity by calponin in intact contracting smooth muscles.
Biochemical and biophysical research communications 2000;279(1):150-7.
2000: Yoshimoto R; Hori M; Ozaki H; Karaki H
Proteolysis of acidic calponin by mu-calpain.
Journal of biochemistry 2000;128(6):1045-9.
2000: Kwon S C; Ozaki H; Karaki H
NO donor sodium nitroprusside inhibits excitation-contraction coupling in guinea pig taenia coli.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(6):G1235-41.
2000: Sato K; Satake N; Shibata S; Adachi Y; Karaki H
Mechanisms of vasoinhibitory effect of cardioprotective agent, CP-060S, in rat aorta.
European journal of pharmacology 2000;400(2-3):225-30.
2000: Yamawaki H; Sato K; Hori M; Ozaki H; Nakamura S; Nakayama H; Doi K; Karaki H
Morphological and functional changes of rabbit mesenteric artery cultured with fetal bovine serum.
Life sciences 2000;67(7):807-20.
2000: Miyamoto S; Izumi M; Hori M; Kobayashi M; Ozaki H; Karaki H
Xestospongin C, a selective and membrane-permeable inhibitor of IP(3) receptor, attenuates the positive inotropic effect of alpha-adrenergic stimulation in guinea-pig papillary muscle.
British journal of pharmacology 2000;130(3):650-4.
2000: Izumi M; Miyamoto S; Hori M; Ozaki H; Karaki H
Negative inotropic effect of endothelin-1 in the mouse right ventricle.
European journal of pharmacology 2000;396(2-3):109-17.
2000: Torihashi S; Ozaki H; Hori M; Kita M; Ohota S; Karaki H
Resident macrophages activated by lipopolysaccharide suppress muscle tension and initiate inflammatory response in the gastrointestinal muscle layer.
Histochemistry and cell biology 2000;113(2):73-80.
1999: Nakazawa H; Hori M; Ozaki H; Karaki H
Mechanisms underlying the impairment of endothelium-dependent relaxation in the pulmonary artery of monocrotaline-induced pulmonary hypertensive rats.
British journal of pharmacology 1999;128(5):1098-104.
1999: Hori M; Matsuura Y; Yoshimoto R; Ozaki H; Yasumoto T; Karaki H
[Actin depolymerizing action by marine toxin, pectenotoxin-2]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():225P-229P.
1999: Miyamoto S; Ozaki H; Hori M; Endoh M; Karaki H
Tight coupling between the rate of rise of Ca2+ transient and peak twitch contraction in guinea-pig papillary muscle.
European journal of pharmacology 1999;377(2-3):199-207.
1999: Yamawaki H; Sato K; Hori M; Ozaki H; Nakamura S; Nakayama H; Doi K; Karaki H
Impairment of EDR by a long-term PDGF treatment in organ-cultured rabbit mesenteric artery.
The American journal of physiology 1999;277(1 Pt 2):H318-23.
1999: Takizawa S; Ozaki H; Karaki H
Possible involvement of K+ channel opening to the interleukin-1 beta-induced inhibition of vascular smooth muscle contraction.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1999;61(4):357-60.
1999: Yamawaki H; Sato K; Hori M; Ozaki H; Karaki H
Impairment of endothelium-dependent relaxation in the arteries cultured with fetal bovine serum.
European journal of pharmacology 1999;366(2-3):237-42.
1999: Amano K; Hori M; Ozaki H; Karaki H
Agonist-dependent difference in the relationship between cytosolic Ca2+ level and release of vascular relaxing factors in the endothelium of rabbit aortic valve.
European journal of pharmacology 1999;366(2-3):215-21.
1998: Ozaki H; Yamawaki H; Sato K; Hori M; Karaki H
[Long-term effects of growth-activating agents on smooth muscle contraction and endothelial function in organ-cultured rabbit mesenteric artery]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1998;112 Suppl 1():63P-67P.
1998: Kim B K; Ozaki H; Hori M; Takahashi K; Karaki H
Increased contractility of rat uterine smooth muscle at the end of pregnancy.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 1998;121(2):165-73.
1998: Arimitsu M; Mitsui-Saito M; Sato K; Ozaki H; Koga Y; Karaki H
Mechanism of relaxant effect of clonidine in isolated bovine tracheal smooth muscle.
The Journal of pharmacology and experimental therapeutics 1998;286(2):681-7.
1998: Yoshimoto R; Mitsui-Saito M; Ozaki H; Karaki H
Effects of adrenomedullin and calcitonin gene-related peptide on contractions of the rat aorta and porcine coronary artery.
British journal of pharmacology 1998;123(8):1645-54.
1998: Saito S Y; Watabe S; Ozaki H; Kobayashi M; Suzuki T; Kobayashi H; Fusetani N; Karaki H
Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A.
Journal of biochemistry 1998;123(4):571-8.
1998: Izumi M; Mitsui-Saito M; Ozaki H; Karaki H
Cicletanine-induced decreases in cytosolic Ca2+ level and contraction in vascular smooth muscle.
Japanese journal of pharmacology 1998;76(1):57-63.
1998: Hori M; Karaki H
Regulatory mechanisms of calcium sensitization of contractile elements in smooth muscle.
Life sciences 1998;62(17-18):1629-33.
1997: Sato K; Horibe K; Saito-Mitsui M; Hori M; Matsunaga S; Fusetani N; Ozaki H; Karaki H
[Effect of discodermin A, an antimicrobial peptide, on the cytoplasm membrane]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1997;110 Suppl 1():199P-204P.
1997: Abe Y; Saito S; Hori M; Ozaki H; Fusetani N; Karaki H
Stellettamide-A, a novel inhibitor of calmodulin, isolated from a marine sponge.
British journal of pharmacology 1997;121(7):1309-14.
1997: Takizawa S; Ozaki H; Karaki H
Interleukin-1beta-induced, nitric oxide-dependent and -independent inhibition of vascular smooth muscle contraction.
European journal of pharmacology 1997;330(2-3):143-50.
1997: Tajimi M; Hori M; Ozaki H; Karaki H
Effect of phorbol esters on cytosolic Ca2+ level, myosin phosphorylation and muscle tension in high K(+)-stimulated bovine tracheal smooth muscle.
Japanese journal of pharmacology 1997;74(2):195-201.
1997: Karaki H; Ozaki H; Hori M; Mitsui-Saito M; Amano K; Harada K; Miyamoto S; Nakazawa H; Won K J; Sato K
Calcium movements, distribution, and functions in smooth muscle.
Pharmacological reviews 1997;49(2):157-230.
1997: Amano K; Sato K; Hori M; Ozaki H; Karaki H
Palytoxin-induced increase in endothelial Ca2+ concentration in the rabbit aortic valve.
Naunyn-Schmiedeberg's archives of pharmacology 1997;355(6):751-8.
1996: Trongvanichnam K; Mitsui-Saito M; Ozaki H; Karaki H
Effects of chronic oral administration of a high dose of nicorandil on in vitro contractility of rat arterial smooth muscle.
European journal of pharmacology 1996;314(1-2):83-90.
1996: Kim B K; Ozaki H; Hori M; Karaki H
Increased inhibitory effect of phorbol ester on cytosolic Ca2+ level and contraction in rat myometrium after gestation.
Japanese journal of pharmacology 1996;72(2):111-8.
1996: Saito S; Watabe S; Ozaki H; Kigoshi H; Yamada K; Fusetani N; Karaki H
Novel actin depolymerizing macrolide aplyronine A.
Journal of biochemistry 1996;120(3):552-5.
1996: Mitsui-Saito M; Karaki H
Carbachol but not acetylcholine inhibits contraction by the protein kinase C-dependent and -independent pathways in the smooth muscle of guinea pig taenia caeci.
Japanese journal of pharmacology 1996;72(1):23-8.
1996: Saito S; Karaki H
A family of novel actin-inhibiting marine toxins.
Clinical and experimental pharmacology & physiology 1996;23(8):743-6.
1996: Takayama M; Ozaki H; Karaki H
Effects of a myosin light chain kinase inhibitor, wortmannin, on cytoplasmic Ca2+ levels, myosin light chain phosphorylation and force in vascular smooth muscle.
Naunyn-Schmiedeberg's archives of pharmacology 1996;354(2):120-7.
1996: Ozaki H; Abe A; Uehigashi Y; Kinoshita M; Hori M; Mitsui-Saito M; Karaki H
Effects of a prostaglandin I2 analog iloprost on cytoplasmic Ca2+ levels and muscle contraction in isolated guinea pig aorta.
Japanese journal of pharmacology 1996;71(3):231-7.
1996: Watabe S; Wada S; Saito S; Matsunaga S; Fusetani N; Ozaki H; Karaki H
Cellular changes of rat embryonic fibroblasts by an actin-polymerization inhibitor, bistheonellide A, from a marine sponge.
Cell structure and function 1996;21(3):199-212.
1996: Trongvanichnam K; Mitsui-Saito M; Ozaki H; Karaki H
Effects of chronic oral administration of isosorbide dinitrate on in vitro contractility of rat arterial smooth muscle.
Japanese journal of pharmacology 1996;71(2):167-73.
1996: Kitajima S; Harada K; Hori M; Ozaki H; Karaki H
Dissociation of P2 purinoceptor-mediated increase in intracellular Ca2+ level from myosin light chain phosphorylation and contraction in rat aorta.
British journal of pharmacology 1996;118(3):543-8.
1996: Trongvanichnam K; Mitsui-Saito M; Ozaki H; Karaki H
Effects of chronic oral administration of levcromakalim on in vitro contractile responses of arterial smooth muscle.
European journal of pharmacology 1996;303(1-2):39-45.
1996: Karaki H; Mitsui-Saito M; Takimoto M; Oda K; Okada T; Ozaki T; Kunieda T
Lack of endothelin ETB receptor binding and function in the rat with a mutant ETB receptor gene.
Biochemical and biophysical research communications 1996;222(1):139-43.
1996: Saito S Y; Hori M; Ozaki H; Karaki H
Cytochalasin D inhibits smooth muscle contraction by directly inhibiting contractile apparatus.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 1996;32(2):51-60.
1996: Kuwahara M; Masuda T; Tsubone H; Sugano S; Karaki H
Cardiovascular responses mediated by two types of endothelin ET(B) receptor in spontaneously hypertensive and Wistar-Kyoto rats.
European journal of pharmacology 1996;296(1):55-63.
1995: Sudjarwo S A; Karaki H
Role of protein kinase C in the endothelin-induced contraction in the rabbit saphenous vein.
European journal of pharmacology 1995;294(1):261-9.
1995: Yoneyama T; Hori M; Tanaka T; Matsuda Y; Karaki H
Endothelin ETA and ETB receptors facilitating parasympathetic neurotransmission in the rabbit trachea.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1084-9.
1995: Han S Z; Ouchi Y; Karaki H; Orimo H
Inhibitory effects of insulin on cytosolic Ca2+ level and contraction in the rat aorta. Endothelium-dependent and -independent mechanisms.
Circulation research 1995;77(4):673-8.
1995: Tajimi M; Hori M; Mitsui M; Ozaki H; Karaki H
Inhibitory effect of forskolin on myosin phosphorylation-dependent and independent contractions in bovine tracheal smooth muscle.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 1995;31(4):129-42.
1995: Kim B K; Ozaki H; Lee S M; Karaki H
Increased sensitivity of rat myometrium to the contractile effect of platelet activating factor before delivery.
British journal of pharmacology 1995;115(7):1211-4.
1995: Karaki H; Sudjarwo S A; Shimamoto N; Wakimasu M; Fujino M
Effects of a potent, non-selective endothelin receptor antagonist, [Thr18, gamma-MeLeu19]-endothelin-1, on the isolated blood vessels.
Biochemical and biophysical research communications 1995;212(2):421-7.
1995: Han S Z; Karaki H; Ouchi Y; Akishita M; Orimo H
17 beta-Estradiol inhibits Ca2+ influx and Ca2+ release induced by thromboxane A2 in porcine coronary artery.
Circulation 1995;91(10):2619-26.
1995: Hori M; Shimizu K; Nakajyo S; Karaki H; Urakawa N
The inhibitory effect of Li+ on contractile elements of intestinal smooth muscle.
Japanese journal of pharmacology 1995;68(1):111-8.
1995: Sudjarwo S A; Hori M; Tanaka T; Matsuda Y; Karaki H
Coupling of the endothelin ETA and ETB receptors to Ca2+ mobilization and Ca2+ sensitization in vascular smooth muscle.
European journal of pharmacology 1995;289(2):197-204.
1995: Yoneyama T; Hori M; Makatani M; Yamamura T; Tanaka T; Matsuda Y; Karaki H
Subtypes of endothelin ETA and ETB receptors mediating tracheal smooth muscle contraction.
Biochemical and biophysical research communications 1995;207(2):668-74.
1995: Orimo H; Han S Z; Tabata R E; Stergiopoulos K; Ouchi Y; Karaki H
Calcium channel blocking substances for prevention of atherosclerosis.
Annals of the New York Academy of Sciences 1995;748():447-60.
1994: Amano K; Hori M; Ozaki H; Matsuda Y; Karaki H
Ca++ mobilization mediated by endothelin ETA receptor in endothelium of rabbit aortic valve.
The Journal of pharmacology and experimental therapeutics 1994;271(3):1359-64.
1994: Karaki H; Sudjarwo S A; Hori M
Novel antagonist of endothelin ETB1 and ETB2 receptors, BQ-788: effects on blood vessel and small intestine.
Biochemical and biophysical research communications 1994;205(1):168-73.
1994: Saito S; Watabe S; Ozaki H; Fusetani N; Karaki H
Mycalolide B, a novel actin depolymerizing agent.
The Journal of biological chemistry 1994;269(47):29710-4.
1994: Karaki H; Sudjarwo S A; Hori M; Tanaka T; Matsuda Y
Endothelin ETB receptor antagonist, RES-701-1: effects on isolated blood vessels and small intestine.
European journal of pharmacology 1994;262(3):255-9.
1994: Sudjarwo S A; Hori M; Tanaka T; Matsuda Y; Okada T; Karaki H
Subtypes of endothelin ETA and ETB receptors mediating venous smooth muscle contraction.
Biochemical and biophysical research communications 1994;200(1):627-33.
1994: Kitajima S; Ozaki H; Karaki H
Role of different subtypes of P2 purinoceptor on cytosolic Ca2+ levels in rat aortic smooth muscle.
European journal of pharmacology 1994;266(3):263-7.
1994: Hori M; Sudjarwo S A; Oda K; Urade Y; Karaki H
Two types of endothelin B receptors mediating relaxation in the guinea pig ileum.
Life sciences 1994;54(10):645-52.
1993: Hori M; Sato K; Miyamoto S; Ozaki H; Karaki H
Different pathways of calcium sensitization activated by receptor agonists and phorbol esters in vascular smooth muscle.
British journal of pharmacology 1993;110(4):1527-31.
1993: Takizawa S; Hori M; Ozaki H; Karaki H
Effects of isoquinoline derivatives, HA1077 and H-7, on cytosolic Ca2+ level and contraction in vascular smooth muscle.
European journal of pharmacology 1993;250(3):431-7.
1993: Abe A; Karaki H
Synergistic effects of cyclic AMP-related vasodilators and the phosphatase inhibitor okadaic acid.
Japanese journal of pharmacology 1993;63(1):129-31.
1993: Kitajima S; Ozaki H; Karaki H
The effects of ATP and alpha,beta-methylene-ATP on cytosolic Ca2+ level and force in rat isolated aorta.
British journal of pharmacology 1993;110(1):263-8.
1993: Hosoya N; Mitsui M; Yazama F; Ishihara H; Ozaki H; Karaki H; Hartshorne D J; Mohri H
Changes in the cytoskeletal structure of cultured smooth muscle cells induced by calyculin-A.
Journal of cell science 1993;105 ( Pt 4)():883-90.
1993: Karaki H; Sudjarwo S A; Hori M; Takai M; Urade Y; Okada T
Induction of endothelium-dependent relaxation in the rat aorta by IRL 1620, a novel and selective agonist at the endothelin ETB receptor.
British journal of pharmacology 1993;109(2):486-90.
1993: Mitsui M; Karaki H
Contractile and relaxant effects of phorbol ester in the intestinal smooth muscle of guinea-pig taenia caeci.
British journal of pharmacology 1993;109(1):229-33.
1993: Hori M; Saito S; Shin Y Z; Ozaki H; Fusetani N; Karaki H
Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge.
FEBS letters 1993;322(2):151-4.
1993: Mitsui M; Abe A; Tajimi M; Karaki H
Leakage of the fluorescent Ca2+ indicator fura-2 in smooth muscle.
Japanese journal of pharmacology 1993;61(3):165-70.
1993: Hagiwara S; Mitsui M; Karaki H
Effects of felodipine, nifedipine and verapamil on cytosolic Ca2+ and contraction in vascular smooth muscle.
European journal of pharmacology 1993;234(1):1-7.
1993: Karaki H; Sudjarwo S A; Hori M; Sakata K; Urade Y; Takai M; Okada T
ETB receptor antagonist, IRL 1038, selectively inhibits the endothelin-induced endothelium-dependent vascular relaxation.
European journal of pharmacology 1993;231(3):371-4.
1993: Kwon S C; Ozaki H; Hori M; Karaki H
Isoproterenol changes the relationship between cytosolic Ca2+ and contraction in guinea pig taenia caecum.
Japanese journal of pharmacology 1993;61(1):57-64.
1993: Sudjarwo S A; Hori M; Takai M; Urade Y; Okada T; Karaki H
A novel subtype of endothelin B receptor mediating contraction in swine pulmonary vein.
Life sciences 1993;53(5):431-7.
1992: Sudjarwo S A; Hori M; Karaki H
Effect of endothelin-3 on cytosolic calcium level in vascular endothelium and on smooth muscle contraction.
European journal of pharmacology 1992;229(2-3):137-42.
1992: Abe A; Karaki H
Calcium channel blocker-like action of 1,9-dideoxyforskolin in vascular smooth muscle.
Japanese journal of pharmacology 1992;60(4):389-92.
1992: Sanagi M; Ozaki H; Mitsui M; Karaki H
Mechanism of relaxing action of the antiasthmatic drug, azelastine, in isolated porcine tracheal smooth muscle.
European journal of pharmacology 1992;222(2-3):247-55.
1992: Satoh T; Moriyama T; Kuriki H; Karaki H
Calcium channel blocker-like action of reserpine in smooth muscle.
Japanese journal of pharmacology 1992;60(3):291-3.
1992: Kim B K; Mitsui M; Karaki H
The long-term inhibitory effect of a Ca2+ channel blocker, nisoldipine, on cytosolic Ca2+ and contraction in vascular smooth muscle.
European journal of pharmacology 1992;223(2-3):157-62.
1992: Sakata K; Karaki H
Effects of endothelin on cytosolic Ca2+ level and mechanical activity in rat uterine smooth muscle.
European journal of pharmacology 1992;221(1):9-15.
1992: Hori M; Sato K; Sakata K; Ozaki H; Takano-Ohmuro H; Tsuchiya T; Sugi H; Kato I; Karaki H
Receptor agonists induce myosin phosphorylation-dependent and phosphorylation-independent contractions in vascular smooth muscle.
The Journal of pharmacology and experimental therapeutics 1992;261(2):506-12.
1992: Sato K; Hori M; Ozaki H; Takano-Ohmuro H; Tsuchiya T; Sugi H; Karaki H
Myosin phosphorylation-independent contraction induced by phorbol ester in vascular smooth muscle.
The Journal of pharmacology and experimental therapeutics 1992;261(2):497-505.
1992: Abe A; Karaki H
Mechanisms underlying the inhibitory effect of dibutyryl cyclic AMP in vascular smooth muscle.
European journal of pharmacology 1992;211(3):305-11.
1992: Karaki H; Hori M; Sato K; Ozaki H; Takano-Ohmuro H; Tsuchiya T; Sugi H
Regulation of smooth muscle contraction by the myosin light chain phosphorylation-dependent and -independent mechanisms.
Advances in experimental medicine and biology 1992;311():407-8.
1992: Sato K; Karaki H
Activation of protein kinase C is not involved in the vascular contraction induced by receptor agonists.
Japanese journal of pharmacology 1992;58 Suppl 2():414P.
1991: Tajimi M; Ozaki H; Sato K; Karaki H
Effect of a novel inhibitor of cyclic AMP phosphodiesterase, E-1020, on cytosolic Ca++ level and contraction in vascular smooth muscle.
Naunyn-Schmiedeberg's archives of pharmacology 1991;344(5):602-10.
1991: Hori M; Magae J; Han Y G; Hartshorne D J; Karaki H
A novel protein phosphatase inhibitor, tautomycin. Effect on smooth muscle.
FEBS letters 1991;285(1):145-8.
1991: Ishihara H; Karaki H
Inhibitory effect of 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8) in vascular smooth muscle.
European journal of pharmacology 1991;197(2-3):181-6.
1991: Karaki H; Sato K; Ozaki H
Different effects of verapamil on cytosolic Ca2+ and contraction in norepinephrine-stimulated vascular smooth muscle.
Japanese journal of pharmacology 1991;55(1):35-42.
1991: Sakata K; Karaki H
Effects of a novel smooth muscle relaxant, KT-362, on contraction and cytosolic Ca2+ level in the rat aorta.
British journal of pharmacology 1991;102(1):174-8.
1990: Karaki H
[Calcium regulation of smooth muscle contractility]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1990;96(6):289-99.
1990: Anabuki J; Hori M; Ozaki H; Kato I; Karaki H
Mechanisms of pinacidil-induced vasodilatation.
European journal of pharmacology 1990;190(3):373-9.
1990: Sato K; Ozaki H; Karaki H
Differential effects of carbachol on cytosolic calcium levels in vascular endothelium and smooth muscle.
The Journal of pharmacology and experimental therapeutics 1990;255(1):114-9.
1990: Ozaki H; Kwon S C; Tajimi M; Karaki H
Changes in cytosolic CA2+ and contraction induced by various stimulants and relaxants in canine tracheal smooth muscle.
Pflügers Archiv : European journal of physiology 1990;416(4):351-9.
1990: Mitsui M; Karaki H
Dual effects of carbachol on cytosolic Ca2+ and contraction in intestinal smooth muscle.
The American journal of physiology 1990;258(5 Pt 1):C787-93.
1990: Sakata K; Karaki H
Phorbol ester-induced release of endothelium-derived relaxing factor.
European journal of pharmacology 1990;179(1-2):207-10.
1990: Mitsui M; Nakao K; Inukai T; Karaki H
Inhibitory effects of cadralazine and its metabolite, ISF-2405, on contractions and the level of cytosolic Ca2+ in vascular smooth muscle.
European journal of pharmacology 1990;178(2):171-7.
1990: Ozaki H; Kasai H; Hori M; Sato K; Ishihara H; Karaki H
Direct inhibition of chicken gizzard smooth muscle contractile apparatus by caffeine.
Naunyn-Schmiedeberg's archives of pharmacology 1990;341(3):262-7.
1990: Ozaki H; Ohyama T; Sato K; Karaki H
Ca2(+)-dependent and independent mechanisms of sustained contraction in vascular smooth muscle of rat aorta.
Japanese journal of pharmacology 1990;52(3):509-12.
1989: Sakata K; Ozaki H; Kwon S C; Karaki H
Effects of endothelin on the mechanical activity and cytosolic calcium level of various types of smooth muscle.
British journal of pharmacology 1989;98(2):483-92.
1989: Karaki H; Mitsui M; Nagase H; Ozaki H; Shibata S; Uemura D
Inhibitory effect of a toxin okadaic acid, isolated from the black sponge on smooth muscle and platelets.
British journal of pharmacology 1989;98(2):590-6.
1989: Ozaki H; Sato K; Sakata K; Karaki H
Endothelin dissociates muscle tension from cytosolic Ca2+ in vascular smooth muscle of rat carotid artery.
Japanese journal of pharmacology 1989;50(4):521-4.
1989: Ishihara H; Ozaki H; Sato K; Hori M; Karaki H; Watabe S; Kato Y; Fusetani N; Hashimoto K; Uemura D
Calcium-independent activation of contractile apparatus in smooth muscle by calyculin-A.
The Journal of pharmacology and experimental therapeutics 1989;250(1):388-96.
1989: Abe A; Karaki H
Effect of forskolin on cytosolic Ca++ level and contraction in vascular smooth muscle.
The Journal of pharmacology and experimental therapeutics 1989;249(3):895-900.
1989: Ozaki H; Moriyama T; Karaki H; Kohama K; Cragoe E J
Direct inhibition of contractile apparatus by analogues of amiloride in the smooth muscle of guinea-pig taenia caecum and chicken gizzard.
Biochemical pharmacology 1989;38(6):915-22.
1989: Ishihara H; Martin B L; Brautigan D L; Karaki H; Ozaki H; Kato Y; Fusetani N; Watabe S; Hashimoto K; Uemura D
Calyculin A and okadaic acid: inhibitors of protein phosphatase activity.
Biochemical and biophysical research communications 1989;159(3):871-7.
1988: Karaki H; Sato K; Ozaki H; Murakami K
Effects of sodium nitroprusside on cytosolic calcium level in vascular smooth muscle.
European journal of pharmacology 1988;156(2):259-66.
1988: Sato K; Ozaki H; Karaki H
Multiple effects of caffeine on contraction and cytosolic free Ca2+ levels in vascular smooth muscle of rat aorta.
Naunyn-Schmiedeberg's archives of pharmacology 1988;338(4):443-8.
1988: Ozaki H; Satoh T; Karaki H; Ishida Y
Regulation of metabolism and contraction by cytoplasmic calcium in the intestinal smooth muscle.
The Journal of biological chemistry 1988;263(28):14074-9.
1988: Satoh T; Karaki H
Release of prostaglandins during the contraction of rat aorta induced by ouabain and K+-free solution.
Japanese journal of pharmacology 1988;48(2):249-55.
1988: Karaki H; Nagase H; Ohizumi Y; Satake N; Shibata S
Palytoxin-induced contraction and release of endogenous noradrenaline in rat tail artery.
British journal of pharmacology 1988;95(1):183-8.
1988: Ahn H Y; Karaki H
Inhibitory effects of procaine on contraction and calcium movement in vascular and intestinal smooth muscles.
British journal of pharmacology 1988;94(3):789-96.
1988: Karaki H; Sato K; Ozaki H
Different effects of norepinephrine and KCl on the cytosolic Ca2+-tension relationship in vascular smooth muscle of rat aorta.
European journal of pharmacology 1988;151(2):325-8.
1988: Sato K; Ozaki H; Karaki H
Changes in cytosolic calcium level in vascular smooth muscle strip measured simultaneously with contraction using fluorescent calcium indicator fura 2.
The Journal of pharmacology and experimental therapeutics 1988;246(1):294-300.
1988: Karaki H; Mitsui M
Verapamil-sensitive and less sensitive contractions in the intestinal smooth muscle of the guinea-pig taenia caeci.
Japanese journal of pharmacology 1988;46(4):325-30.
1988: Abe A; Karaki H
Inhibitory effects of forskolin on vascular smooth muscle of rabbit aorta.
Japanese journal of pharmacology 1988;46(3):293-301.
1988: Ahn H Y; Karaki H; Urakawa N
Inhibitory effects of caffeine on contractions and calcium movement in vascular and intestinal smooth muscle.
British journal of pharmacology 1988;93(2):267-74.
1988: Karaki H; Weiss G B
Calcium release in smooth muscle.
Life sciences 1988;42(2):111-22.
1987: Ozaki H; Ishihara H; Kohama K; Nonomura Y; Shibata S; Karaki H
Calcium-independent phosphorylation of smooth muscle myosin light chain by okadaic acid isolated from black sponge (Halichondria okadai).
The Journal of pharmacology and experimental therapeutics 1987;243(3):1167-73.
1987: Ozaki H; Sato K; Satoh T; Karaki H
Simultaneous recordings of calcium signals and mechanical activity using fluorescent dye fura 2 in isolated strips of vascular smooth muscle.
Japanese journal of pharmacology 1987;45(3):429-33.
1987: Karaki H; Nagase H
Low temperature augments the endothelium-dependent relaxation in isolated rat aorta.
European journal of pharmacology 1987;142(1):129-32.
1987: Ozaki H; Kojima T; Moriyama T; Karaki H; Urakawa N; Kohama K; Nonomura Y
Inhibition by amiloride of contractile elements in smooth muscle of guinea pig taenia cecum and chicken gizzard.
The Journal of pharmacology and experimental therapeutics 1987;243(1):370-7.
1987: Nagase H; Karaki H
Palytoxin-induced contraction and release of prostaglandins and norepinephrine in the aorta.
The Journal of pharmacology and experimental therapeutics 1987;242(3):1120-5.
1987: Murakami K; Karaki H; Urakawa N
Comparison of the inhibitory effects of nicorandil, nitroglycerin and isosorbide dinitrate on vascular smooth muscle of rabbit aorta.
European journal of pharmacology 1987;141(2):195-202.

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