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Richard Karas

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Kazutaka Ueda; Richard H Karas
Emerging evidence of the importance of rapid, non-nuclear estrogen receptor signaling in the cardiovascular system.
Afshin Ehsan; Carol Galayda; Mark Aronovitz; Michael S Conte; Richard H Karas; Adam P McGraw; Iris Z Jaffe
Mineralocorticoid receptor antagonism inhibits vein graft remodeling in mice.
Jin Zhao; Tanya B Kershaw; Qing Lu; Mark Aronovitz; Wendy E Baur; Greta M Haselmann; Gregory A Imbrie; Lakshmanan K Iyer; Richard H Karas
Estrogen receptor-mediated regulation of microRNA inhibits proliferation of vascular smooth muscle cells.

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2013: Kazutaka Ueda; Richard H Karas
Emerging evidence of the importance of rapid, non-nuclear estrogen receptor signaling in the cardiovascular system.
Steroids 2013;78(6):589-96.
2013: Afshin Ehsan; Carol Galayda; Mark Aronovitz; Michael S Conte; Richard H Karas; Adam P McGraw; Iris Z Jaffe
Mineralocorticoid receptor antagonism inhibits vein graft remodeling in mice.
The Journal of thoracic and cardiovascular surgery 2013;145(6):1642-1649.e1.
2013: Jin Zhao; Tanya B Kershaw; Qing Lu; Mark Aronovitz; Wendy E Baur; Greta M Haselmann; Gregory A Imbrie; Lakshmanan K Iyer; Richard H Karas
Estrogen receptor-mediated regulation of microRNA inhibits proliferation of vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(2):257-65.
2013: Paul M Lavigne; Richard H Karas
The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
Journal of the American College of Cardiology 2013;61(4):440-6.
2012: Mikio Kato; Masafumi Myoishi; Guang-Rong Wang; Yuich Abe; Robert Blanton; Timothy J Judson; Richard H Karas; Michael E Mendelsohn
Direct binding and regulation of RhoA protein by cyclic GMP-dependent protein kinase Iα.
The Journal of biological chemistry 2012;287(49):41342-51.
2012: Robert M Blanton; Richard H Karas; David A Kass; Angela M Lane; Robert Piotrowski; Eiki Takimoto; Mark Aronovitz; Michael E Mendelsohn
Protein kinase g iα inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo.
Journal of the American Heart Association 2012;1(5):e003731.
2012: Navin K Kapur; Mark J Aronovitz; Corey Baker; S Ananth Karumanchi; David A Kass; Michelle Letarte; Emily Mackey; Michael E Mendelsohn; Vikram Paruchuri; Xiaoying Qiao; Szuhuei Wilson; Adil A Yunis; Richard H Karas
Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure.
Circulation 2012;125(22):2728-38.
2012: Navin K Kapur; Richard H Karas; Emily E Mackey; Najwa N Mohammad; Vikram Paruchuri; Xiaoying Qiao; Ameer Shah; Chetan Shenoy; Szuhuei Wilson; Adil A Yunis; Michele L Esposito; Iris Z Jaffe
Distinct effects of unfractionated heparin versus bivalirudin on circulating angiogenic peptides.
PloS one 2012;7(4):e34344.
2011: Navin K Kapur; Kevin S Heffernan; Adil A Yunis; Tuan A Nguyen; Mark J Aronovitz; Peter Parpos; Szuhuei Wilson; Corey K Baker; Michele L Esposito; Ameer Shah; Carey Kimmelstiel; Andrew Weintraub; Richard H Karas; Michael Mendelsohn
Elevated soluble fms-like tyrosine kinase-1 levels in acute coronary occlusion.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(2):443-50.
2011: Eshan Patvardhan; Jenny Ruan; Patrick Warner; Kevin S Heffernan; Michael Hession; Richard H Karas; Jeffrey T Kuvin
Augmentation index derived from peripheral arterial tonometry correlates with cardiovascular risk factors.
Cardiology research and practice 2011;2011():253758.
2011: Kevin S Heffernan; Ramya Suryadevara; Eshan A Patvardhan; Paula Mooney; Richard H Karas; Jeffrey T Kuvin
Effect of atenolol vs metoprolol succinate on vascular function in patients with hypertension.
Clinical cardiology 2011;34(1):39-44.
2010: Haseeb Jafri; Alawi A Alsheikh-Ali; Richard H Karas
Meta-analysis: statin therapy does not alter the association between low levels of high-density lipoprotein cholesterol and increased cardiovascular risk.
Annals of internal medicine 2010;153(12):800-8.
2010: Navin K Kapur; Kevin S Heffernan; Adil A Yunis; Peter Parpos; Michael S Kiernan; Nikhil A Sahasrabudhe; Carey Kimmelstiel; David A Kass; Richard H Karas; Michael Mendelsohn
Usefulness of soluble endoglin as a noninvasive measure of left ventricular filling pressure in heart failure.
The American journal of cardiology 2010;106(12):1770-6.
2010: Adam J Saltzman; Sung W Choi; Alexandra Dabreo; Wendy E Baur; Eric Weiss; Khan Nguyen; Fumiyuki Ishibashi; Flore F Celestin; Darshak H Karia; Natesa G Pandian; Richard H Karas; Sergio Waxman
Endothelial progenitor cells delivered into the pericardial space incorporate into areas of ischemic myocardium.
Cardiovascular revascularization medicine : including molecular interventions 2010;11(4):241-8.
2010: Erica L Brooks; Jeffrey T Kuvin; Richard H Karas
Niacin's role in the statin era.
Expert opinion on pharmacotherapy 2010;11(14):2291-300.
2010: Kevin S Heffernan; Eshan A Patvardhan; Michael Hession; Jenny Ruan; Richard H Karas; Jeffrey T Kuvin
Elevated augmentation index derived from peripheral arterial tonometry is associated with abnormal ventricular-vascular coupling.
Clinical physiology and functional imaging 2010;30(5):313-7.
2010: Erika M Felix-Getzik; Jeffrey T Kuvin; Richard H Karas
Nonoptimal high-density lipoprotein cholesterol levels are highly prevalent in patients presenting with acute coronary syndromes and well-controlled low-density lipoprotein cholesterol levels.
Journal of clinical lipidology 2010;4(4):265-71.
2010: Haseeb Jafri; Alawi A Alsheikh-Ali; Richard H Karas
Baseline and on-treatment high-density lipoprotein cholesterol and the risk of cancer in randomized controlled trials of lipid-altering therapy.
Journal of the American College of Cardiology 2010;55(25):2846-54.
2010: S Sanyal; Jeffrey T Kuvin; Richard H Karas
Niacin and laropiprant.
Drugs of today (Barcelona, Spain : 1998) 2010;46(6):371-8.
2010: C Michael Welzig; Ho-Jin Park; Jack Naggar; Deborah Confalone; Joanne Rhofiry; Julie Shea; Richard H Karas; N A Mark Estes; Jonas B Galper
Differential effects of statins (pravastatin or simvastatin) on ventricular ectopic complexes: Galpha(i2), a possible molecular marker for ventricular irritability.
The American journal of cardiology 2010;105(8):1112-7.
2010: Kevin S Heffernan; Richard H Karas; Eshan A Patvardhan; Jeffrey T Kuvin
Endothelium-dependent vasodilation is associated with exercise capacity in smokers and non-smokers.
Vascular medicine (London, England) 2010;15(2):119-25.
2010: Kevin S Heffernan; Richard H Karas; Eshan A Patvardhan; Haseeb Jafri; Jeffrey T Kuvin
Peripheral arterial tonometry for risk stratification in men with coronary artery disease.
Clinical cardiology 2010;33(2):94-8.
2010: Kevin S Heffernan; Richard H Karas; Paula J Mooney; Ayan R Patel; Jeffrey T Kuvin
Pulse wave amplitude is associated with brachial artery diameter: implications for gender differences in microvascular function.
Vascular medicine (London, England) 2010;15(1):39-45.
2010: Kevin S Heffernan; Craig A Napolitano; Martin S Maron; Eshan A Patvardhan; Ayan R Patel; Natesa G Pandian; Richard H Karas; Jeffrey T Kuvin
Peripheral vascular endothelial function in patients with hypertrophic cardiomyopathy.
The American journal of cardiology 2010;105(1):112-5.
2010: Eshan A Patvardhan; Kevin S Heffernan; Jenny M Ruan; Morgan I Soffler; Richard H Karas; Jeffrey T Kuvin
Assessment of vascular endothelial function with peripheral arterial tonometry: information at your fingertips?
Cardiology in review 2010;18(1):20-8.
2009: Ho-Jin Park; Yali Zhang; Chuang Du; C Michael Welzig; Christopher Madias; Mark Aronovitz; Serban P Georgescu; Isaac Naggar; Bo Wang; Young-Bum Kim; Robert O Blaustein; Richard H Karas; Ronglih Liao; Clayton E Mathews; Jonas B Galper
Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita mice.
Circulation research 2009;105(3):287-94.
2009: Alawi A Alsheikh-Ali; Richard H Karas
Ezetimibe, and the combination of ezetimibe/simvastatin, and risk of cancer: A post-marketing analysis.
Journal of clinical lipidology 2009;3(2):138-42.
2009: Alawi A Alsheikh-Ali; Richard H Karas
The relationship of statins to rhabdomyolysis, malignancy, and hepatic toxicity: evidence from clinical trials.
Current atherosclerosis reports 2009;11(2):100-4.
2009: Haseeb Jafri; Alawi A Alsheikh-Ali; Paula Mooney; Carey D Kimmelstiel; Richard H Karas; Jeffrey T Kuvin
Extended-release niacin reduces LDL particle number without changing total LDL cholesterol in patients with stable CAD.
Journal of clinical lipidology 2009;3(1):45-50.
2009: Cam Donaldson; Sarah Eder; Corey Baker; Mark Aronovitz; Alexandra Dabreo Weiss; Monica Hall-Porter; Feng Wang; Adam Ackerman; Richard H Karas; Jeffery D Molkentin; Richard D Patten
Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation.
Circulation research 2009;104(2):265-75, 11p following 275.
2008: Alawi A Alsheikh-Ali; Thomas A Trikalinos; david kent; Richard H Karas
Statins, low-density lipoprotein cholesterol, and risk of cancer.
Journal of the American College of Cardiology 2008;52(14):1141-7.
2008: Simon K Michael; Howard K Surks; Yuepeng Wang; Yan Zhu; Robert Blanton; Michelle Jamnongjit; Mark Aronovitz; Wendy E Baur; Kenichi Ohtani; Michael K Wilkerson; Adrian D Bonev; Mark T Nelson; Richard H Karas; Michael Mendelsohn
High blood pressure arising from a defect in vascular function.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(18):6702-7.
2008: Alawi A Alsheikh-Ali; Richard H Karas
The safety of niacin in the US Food and Drug Administration adverse event reporting database.
The American journal of cardiology 2008;101(8A):9B-13B.
2008: Richard D Patten; Isaac Pourati; Mark Aronovitz; Alawi A Alsheikh-Ali; Sarah Eder; Thomas Force; Michael Mendelsohn; Richard H Karas
17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload.
Journal of cardiac failure 2008;14(3):245-53.
2008: Noa Holoshitz; Alawi A Alsheikh-Ali; Richard H Karas
Relative safety of gemfibrozil and fenofibrate in the absence of concomitant cerivastatin use.
The American journal of cardiology 2008;101(1):95-7.
2008: Ho-Jin Park; Serban P Georgescu; Chuang Du; Christopher Madias; Mark Aronovitz; C Michael Welzig; Bo Wang; Ulrike Begley; Yali Zhang; Robert O Blaustein; Richard D Patten; Richard H Karas; Herbert H Van Tol; Timothy F Osborne; Hitoshi Shimano; Ronglih Liao; Mark S Link; Jonas B Galper
Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.
The Journal of clinical investigation 2008;118(1):259-71.
2007: Alawi A Alsheikh-Ali; Jen-Liang Lin; Paul Abourjaily; Dineli Ahearn; Jeffrey T Kuvin; Richard H Karas
Prevalence of low high-density lipoprotein cholesterol in patients with documented coronary heart disease or risk equivalent and controlled low-density lipoprotein cholesterol.
The American journal of cardiology 2007;100(10):1499-501.
2007: Sanjukta Sanyal; Richard H Karas; Jeffrey T Kuvin
Present-day uses of niacin: effects on lipid and non-lipid parameters.
Expert opinion on pharmacotherapy 2007;8(11):1711-7.
2007: Alawi A Alsheikh-Ali; Prasad Maddukuri; Hui Han; Richard H Karas
Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials.
Journal of the American College of Cardiology 2007;50(5):409-18.
2007: Raja C Pullatt; Mamatha Reddy Gadarla; Richard H Karas; Alawi A Alsheikh-Ali; Paul D Thompson
Tendon rupture associated with simvastatin/ezetimibe therapy.
The American journal of cardiology 2007;100(1):152-3.
2007: Raegan O'Lone; Katrin Knorr; Iris Z Jaffe; Michael E Schaffer; Paolo G V Martini; Richard H Karas; Jadwiga R Bienkowska; Michael Mendelsohn; Ulla Hansen
Estrogen receptors alpha and beta mediate distinct pathways of vascular gene expression, including genes involved in mitochondrial electron transport and generation of reactive oxygen species.
Molecular endocrinology (Baltimore, Md.) 2007;21(6):1281-96.
2007: Inga Peter; Gordon S Huggins; Amanda M Shearman; Arthur Pollak; Christopher Schmid; L Adrienne Cupples; Serkalem Demissie; Richard D Patten; Richard H Karas; David E Housman; Michael Mendelsohn; Ramachandran S Vasan; Emelia Benjamin
Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha gene.
Hypertension 2007;49(5):1000-6.
2007: Christina Kaldany Isacson; Qing Lu; Richard H Karas; Daniel H Cox
RACK1 is a BKCa channel binding protein.
American journal of physiology. Cell physiology 2007;292(4):C1459-66.
2007: Hui Joyce Li; Zaffar Haque; Qing Lu; Li Li; Richard H Karas; Michael Mendelsohn
Steroid receptor coactivator 3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4065-70.
2007: Jeffrey T Kuvin; Anish Mammen; Paula Mooney; Alawi A Alsheikh-Ali; Richard H Karas
Assessment of peripheral vascular endothelial function in the ambulatory setting.
Vascular medicine (London, England) 2007;12(1):13-6.
2007: Alawi A Alsheikh-Ali; Richard H Karas
Safety of lovastatin/extended release niacin compared with lovastatin alone, atorvastatin alone, pravastatin alone, and simvastatin alone (from the United States Food and Drug Administration adverse event reporting system).
The American journal of cardiology 2007;99(3):379-81.
2006: Prem Soman; Devang M Dave; James E Udelson; Hui Han; Husam Z Ouda; Ayan R Patel; Richard H Karas; Jeffrey T Kuvin
Vascular endothelial dysfunction is associated with reversible myocardial perfusion defects in the absence of obstructive coronary artery disease.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2006;13(6):756-60.
2006: Marietta S Ambrose; David DeNofrio; Jeffrey T Kuvin; Natesa G Pandian; Richard H Karas; Ayan R Patel
Low levels of high-density lipoprotein cholesterol are associated with vascular remodeling in cardiac transplant recipients.
Transplantation proceedings 2006;38(9):3016-20.
2006: Alawi A Alsheikh-Ali; Jen-Liang Lin; Paul Abourjaily; Dineli Ahearn; Jeffrey T Kuvin; Richard H Karas
Extent to which accepted serum lipid goals are achieved in a contemporary general medical population with coronary heart disease risk equivalents.
The American journal of cardiology 2006;98(9):1231-3.
2006: Jeffrey T Kuvin; Devang M Dave; Kathleen A Sliney; Paula Mooney; Ayan R Patel; Carey Kimmelstiel; Richard H Karas
Effects of extended-release niacin on lipoprotein particle size, distribution, and inflammatory markers in patients with coronary artery disease.
The American journal of cardiology 2006;98(6):743-5.
2006: Alawi A Alsheikh-Ali; Husam Z Ouda; Natesa G Pandian; Richard H Karas; Jeffrey T Kuvin
Evaluation of peripheral vascular endothelial function with a portable ultrasound device.
Echocardiography (Mount Kisco, N.Y.) 2006;23(8):623-6.
2006: Richard D Patten; Richard H Karas
Estrogen replacement and cardiomyocyte protection.
Trends in cardiovascular medicine 2006;16(3):69-75.
2006: Serkalem Demissie; L Adrienne Cupples; Amanda M Shearman; Kristen M Gruenthal; Inga Peter; Christopher Schmid; Richard H Karas; David E Housman; Michael Mendelsohn; Jose Ordovas
Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study.
Atherosclerosis 2006;185(1):210-8.
2006: Jeffrey T Kuvin; Alawi A Alsheikh-Ali; Richard H Karas
High-density lipoprotein cholesterol-raising strategies.
Journal of cardiovascular pharmacology 2006;47(2):196-204.
2005: Inga Peter; Amanda M Shearman; Deborah R Zucker; Christopher Schmid; Serkalem Demissie; L Adrienne Cupples; Martin G Larson; Ramachandran S Vasan; Ralph B D'Agostino; Richard H Karas; Michael Mendelsohn; David E Housman; Daniel Levy
Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study.
Journal of hypertension 2005;23(12):2193-200.
2005: Inga Peter; Amanda M Shearman; Ramachandran S Vasan; Deborah R Zucker; Christopher Schmid; Serkalem Demissie; L Adrienne Cupples; Jeffrey T Kuvin; Richard H Karas; Michael Mendelsohn; David E Housman; Emelia Benjamin
Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women.
American journal of hypertension 2005;18(11):1388-95.
2005: Ayan R Patel; Jeffrey T Kuvin; Kathleen A Sliney; William M Rand; Jessica C Chiang; James E Udelson; Natesa G Pandian; Richard H Karas
Gender-based differences in brachial artery flow-mediated vasodilation as an indicator of significant coronary artery disease.
The American journal of cardiology 2005;96(9):1223-6.
2005: Serban P Georgescu; Joyce H Li; Qing Lu; Richard H Karas; Myles Brown; Michael Mendelsohn
Modulator recognition factor 1, an AT-rich interaction domain family member, is a novel corepressor for estrogen receptor alpha.
Molecular endocrinology (Baltimore, Md.) 2005;19(10):2491-501.
2005: Ayan R Patel; Jeffrey T Kuvin; Kathleen A Sliney; William M Rand; Natesa G Pandian; Richard H Karas
Peripheral vascular endothelial function correlates with exercise capacity in women.
Clinical cardiology 2005;28(9):433-6.
2005: Alawi A Alsheikh-Ali; Marietta S Ambrose; Jeffrey T Kuvin; Richard H Karas
The safety of rosuvastatin as used in common clinical practice: a postmarketing analysis.
Circulation 2005;111(23):3051-7.
2005: Michael Mendelsohn; Richard H Karas
Molecular and cellular basis of cardiovascular gender differences.
Science (New York, N.Y.) 2005;308(5728):1583-7.
2005: Alawi A Alsheikh-Ali; Jeffrey T Kuvin; Richard H Karas
High-density lipoprotein cholesterol in the cardiovascular equation: does the "good" still count?
Atherosclerosis 2005;180(2):217-23.
2005: Jeffrey T Kuvin; M Sidhu; Ayan R Patel; Kathleen A Sliney; Natesa G Pandian; Richard H Karas
Pulse pressure and peripheral arterial vasoreactivity.
Journal of human hypertension 2005;19(6):501-2.
2005: Elad Anter; Kai Chen; Oz M Shapira; Richard H Karas; John F Keaney
p38 mitogen-activated protein kinase activates eNOS in endothelial cells by an estrogen receptor alpha-dependent pathway in response to black tea polyphenols.
Circulation research 2005;96(10):1072-8.
2005: Richard D Patten; David DeNofrio; Mohamad El-Zaru; Rahul Kakkar; Jessica Saunders; Flore Celestin; Kenneth Warner; Hassan Rastegar; Kamal R Khabbaz; James E Udelson; Marvin A Konstam; Richard H Karas
Ventricular assist device therapy normalizes inducible nitric oxide synthase expression and reduces cardiomyocyte apoptosis in the failing human heart.
Journal of the American College of Cardiology 2005;45(9):1419-24.
2005: Alawi A Alsheikh-Ali; Richard H Karas
Adverse events with concomitant amiodarone and statin therapy.
Preventive cardiology 2005;8(2):95-7.
2005: Jeffrey T Kuvin; Ayan R Patel; Kathleen A Sliney; Natesa G Pandian; Richard H Karas
Comparison of flow-mediated dilatation of the brachial artery in coronary patients with low-density lipoprotein cholesterol levels <80 mg/dl versus patients with levels 80 to 100 mg/dl.
The American journal of cardiology 2005;95(1):93-5.
2004: Qing Lu; David C Pallas; Howard K Surks; Wendy E Baur; Michael Mendelsohn; Richard H Karas
Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(49):17126-31.
2004: Alawi A Alsheikh-Ali; Jeffrey T Kuvin; Richard H Karas
Risk of adverse events with fibrates.
The American journal of cardiology 2004;94(7):935-8.
2004: Richard D Patten; Isaac Pourati; Mark Aronovitz; Jason Baur; Flore Celestin; Xin Chen; Ashour Michael; Syed Haq; Simone Nuedling; Christian Grohe; Thomas Force; Michael Mendelsohn; Richard H Karas
17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling.
Circulation research 2004;95(7):692-9.
2004: S Mitchell Harman; Eliot A Brinton; Thomas Clarkson; Christopher B Heward; Harvey S Hecht; Richard H Karas; Debra R Judelson; Frederick Naftolin
Is the WHI relevant to HRT started in the perimenopause?
Endocrine 2004;24(3):195-202.
2004: Frederick Naftolin; Hugh S Taylor; Richard H Karas; Eliot A Brinton; Isadore Newman; Thomas B Clarkson; Michael Mendelsohn; Rogerio A Lobo; Debra R Judelson; Lila E Nachtigall; Christopher B Heward; Harvey Hecht; Michael R Jaff; S Mitchell Harman
The Women's Health Initiative could not have detected cardioprotective effects of starting hormone therapy during the menopausal transition.
Fertility and sterility 2004;81(6):1498-501.
2004: Richard H Karas
Current controversies regarding the cardiovascular effects of hormone therapy.
Clinical obstetrics and gynecology 2004;47(2):489-99.
2004: Alawi A Alsheikh-Ali; Richard H Karas
Adverse events with concomitant use of simvastatin or atorvastatin and thiazolidinediones.
The American journal of cardiology 2004;93(11):1417-8, A9.
2004: Geraldine A Finlay; Brian York; Richard H Karas; Barry L Fanburg; Hongbing Zhang; David J Kwiatkowski; Daniel J Noonan
Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2.
The Journal of biological chemistry 2004;279(22):23114-22.
2004: Christine E Young; Richard H Karas; Jeffrey T Kuvin
High-density lipoprotein cholesterol and coronary heart disease.
Cardiology in review 2004;12(2):107-19.
2003: K Mary Tang; Guang-rong Wang; Ping Lu; Richard H Karas; Mark Aronovitz; Scott P Heximer; Kevin M Kaltenbronn; Kendall J Blumer; David Siderovski; Yan Zhu; Michael Mendelsohn; Mary Tang; Guang Wang
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.
Nature medicine 2003;9(12):1506-12.
2003: Amanda M Shearman; L Adrienne Cupples; Serkalem Demissie; Inga Peter; Christopher Schmid; Richard H Karas; Michael Mendelsohn; David E Housman; Daniel Levy
Association between estrogen receptor alpha gene variation and cardiovascular disease.
JAMA : the journal of the American Medical Association 2003;290(17):2263-70.
2003: Isaac Pourati; Carey Kimmelstiel; William M Rand; Richard H Karas
Statin use is associated with enhanced collateralization of severely diseased coronary arteries.
American heart journal 2003;146(5):876-81.
2003: Jeffrey T Kuvin; Ayan R Patel; Mandeep Sidhu; William M Rand; Kathleen A Sliney; Natesa G Pandian; Richard H Karas
Relation between high-density lipoprotein cholesterol and peripheral vasomotor function.
The American journal of cardiology 2003;92(3):275-9.
2003: Jeffrey T Kuvin; Richard H Karas
The effects of LDL reduction and HDL augmentation on physiologic and inflammatory markers.
Current opinion in cardiology 2003;18(4):295-300.
2003: Jeffrey T Kuvin; Ayan R Patel; Kathleen A Sliney; Natesa G Pandian; Jacob Sheffy; Robert P Schnall; Richard H Karas; James E Udelson
Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude.
American heart journal 2003;146(1):168-74.
2003: Jeffrey T Kuvin; Richard H Karas
Clinical utility of endothelial function testing: ready for prime time?
Circulation 2003;107(25):3243-7.
2003: Maria E Rämet; Mika Rämet; Qing Lu; Moriah Nickerson; Markku Savolainen; Amy Malzone; Richard H Karas
High-density lipoprotein increases the abundance of eNOS protein in human vascular endothelial cells by increasing its half-life.
Journal of the American College of Cardiology 2003;41(12):2288-97.
2003: Martin van Eickels; Richard D Patten; Mark Aronovitz; Alawi A Alsheikh-Ali; Kim Gostyla; Flore Celestin; Christian Grohe; Michael Mendelsohn; Richard H Karas
17-beta-estradiol increases cardiac remodeling and mortality in mice with myocardial infarction.
Journal of the American College of Cardiology 2003;41(11):2084-92.
2003: Heather M Abourjaily; Alawi A Alsheikh-Ali; Richard H Karas
Comparison of the frequency of adverse events in patients treated with atorvastatin or simvastatin.
The American journal of cardiology 2003;91(8):999-1002, A7.
2003: Ayan R Patel; Jeffrey T Kuvin; David DeNofrio; Debra Kinan; Kathleen A Sliney; Kalyani P Eranki; Natesa G Pandian; James E Udelson; Marvin A Konstam; Richard H Karas
Peripheral vascular endothelial function correlates with exercise capacity in cardiac transplant recipients.
The American journal of cardiology 2003;91(7):897-9.
2003: Jeffrey T Kuvin; Noyan Gokce; Monika Holbrook; Liza M Hunter; Ayan R Patel; Kathleen A Sliney; Donald E Craven; J Thomas Grayston; John F Keaney; Richard H Karas; Joseph A Vita
Effect of short-term antibiotic treatment on Chlamydia pneumoniae and peripheral endothelial function.
The American journal of cardiology 2003;91(6):732-5.
2003: Qing Lu; Howard K Surks; Heather Ebling; Wendy E Baur; Donald Brown; David C Pallas; Richard H Karas
Regulation of estrogen receptor alpha-mediated transcription by a direct interaction with protein phosphatase 2A.
The Journal of biological chemistry 2003;278(7):4639-45.
2002: Jeffrey T Kuvin; Mika Rämet; Ayan R Patel; Natesa G Pandian; Michael E Mendelsohn; Richard H Karas
A novel mechanism for the beneficial vascular effects of high-density lipoprotein cholesterol: enhanced vasorelaxation and increased endothelial nitric oxide synthase expression.
American heart journal 2002;144(1):165-72.
2002: Alawi A Alsheikh-Ali; Heather M Abourjaily; Richard H Karas
Risk of adverse events with concomitant use of atorvastatin or simvastatin and glucose-lowering drugs (thiazolidinediones, metformin, sulfonylurea, insulin, and acarbose).
The American journal of cardiology 2002;89(11):1308-10.
2002: Gary Pare; Andrée Krust; Richard H Karas; Sonia Dupont; Mark Aronovitz; Pierre Chambon; Michael Mendelsohn
Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury.
Circulation research 2002;90(10):1087-92.
2002: Qing Lu; Heather Ebling; Jens Mittler; Wendy E Baur; Richard H Karas
MAP kinase mediates growth factor-induced nuclear translocation of estrogen receptor alpha.
FEBS letters 2002;516(1-3):1-8.
2002: Samir Saba; Wei Zhu; Mark Aronovitz; N A Mark Estes; Paul J Wang; Michael Mendelsohn; Richard H Karas
Effects of estrogen on cardiac electrophysiology in female mice.
Journal of cardiovascular electrophysiology 2002;13(3):276-80.
2002: Yan Zhu; Zhao Bian; Ping Lu; Richard H Karas; Lin Bao; Daniel Cox; Jeffrey B Hodgin; Philip W Shaul; Peter Thoren; Oliver Smithies; Jan-�ke GUSTAFSSON; Michael Mendelsohn
Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta.
Science (New York, N.Y.) 2002;295(5554):505-8.
2001: Jeffrey T Kuvin; Ayan R Patel; Kathleen A Sliney; Natesa G Pandian; William M Rand; James E Udelson; Richard H Karas
Peripheral vascular endothelial function testing as a noninvasive indicator of coronary artery disease.
Journal of the American College of Cardiology 2001;38(7):1843-9.
2001: Richard H Karas; H Schulten; G Pare; Mark Aronovitz; C Ohlsson; J A Gustafsson; Michael Mendelsohn
Effects of estrogen on the vascular injury response in estrogen receptor alpha, beta (double) knockout mice.
Circulation research 2001;89(6):534-9.
2001: Simone Nuedling; Richard H Karas; Michael Mendelsohn; J A Katzenellenbogen; Benita S Katzenellenbogen; Rainer Meyer; Hans Vetter; Christian Grohé
Activation of estrogen receptor beta is a prerequisite for estrogen-dependent upregulation of nitric oxide synthases in neonatal rat cardiac myocytes.
FEBS letters 2001;502(3):103-8.
2001: Richard H Karas; Martin van Eickels; J P Lydon; S Roddy; M Kwoun; Mark Aronovitz; Wendy E Baur; Orla M Conneely; Bert W O'Malley; Michael Mendelsohn
A complex role for the progesterone receptor in the response to vascular injury.
The Journal of clinical investigation 2001;108(4):611-8.
2001: Jeffrey T Kuvin; Ayan R Patel; Richard H Karas
Need for standardization of noninvasive assessment of vascular endothelial function.
American heart journal 2001;141(3):327-8.
2001: Ayan R Patel; Jeffrey T Kuvin; Natesa G Pandian; J J Smith; James E Udelson; M E Mendelsohn; M A Konstam; Richard H Karas
Heart failure etiology affects peripheral vascular endothelial function after cardiac transplantation.
Journal of the American College of Cardiology 2001;37(1):195-200.
1999: Richard H Karas; Jeffrey B Hodgin; M Kwoun; John Krege; Mark Aronovitz; William C Mackey; Jan-�ke GUSTAFSSON; Kenneth S Korach; Oliver Smithies; Michael Mendelsohn
Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15133-6.
1999: M E Mendelsohn; Richard H Karas
The protective effects of estrogen on the cardiovascular system.
The New England journal of medicine 1999;340(23):1801-11.
1998: Richard H Karas; M E Mendelsohn
Rapid vasomotor effects of estrogen: men are part of the club.
Chest 1998;114(6):1508-9.
1998: V Lindner; S K Kim; Richard H Karas; G G Kuiper; J A Gustafsson; M E Mendelsohn
Increased expression of estrogen receptor-beta mRNA in male blood vessels after vascular injury.
Circulation research 1998;83(2):224-9.
1998: Richard H Karas; E A Gauer; H E Bieber; Wendy E Baur; Michael Mendelsohn
Growth factor activation of the estrogen receptor in vascular cells occurs via a mitogen-activated protein kinase-independent pathway.
The Journal of clinical investigation 1998;101(12):2851-61.
1997: Christian Grohé; S Kahlert; K Löbbert; Michael Stimpel; Richard H Karas; Hans Vetter; Ludwig Neyses
Cardiac myocytes and fibroblasts contain functional estrogen receptors.
FEBS letters 1997;416(1):107-12.
1997: Mark D Iafrati; Richard H Karas; Mark Aronovitz; S Kim; T R Sullivan; D B Lubahn; Thomas F O'Donnell; Kenneth S Korach; Michael Mendelsohn
Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice.
Nature medicine 1997;3(5):545-8.
1997: S Kahlert; Christian Grohé; Richard H Karas; K Löbbert; Ludwig Neyses; Hans Vetter
Effects of estrogen on skeletal myoblast growth.
Biochemical and biophysical research communications 1997;232(2):373-8.
1996: Christian Grohé; S Kahlert; K Löbbert; Rainer Meyer; KW Linz; Richard H Karas; Hans Vetter
Modulation of hypertensive heart disease by estrogen.
Steroids 1996;61(4):201-4.
1996: H Koike; Richard H Karas; W E Baur; Thomas F O'Donnell; M E Mendelsohn
Differential-display polymerase chain reaction identifies nucleophosmin as an estrogen-regulated gene in human vascular smooth muscle cells.
Journal of vascular surgery 1996;23(3):477-82.
1995: Richard H Karas; W E Baur; M van Eickles; M E Mendelsohn
Human vascular smooth muscle cells express an estrogen receptor isoform.
FEBS letters 1995;377(2):103-8.
1995: T R Sullivan; Richard H Karas; Mark Aronovitz; G T Faller; J P Ziar; J J Smith; Thomas F O'Donnell; M E Mendelsohn
Estrogen inhibits the response-to-injury in a mouse carotid artery model.
The Journal of clinical investigation 1995;96(5):2482-8.
1994: M E Mendelsohn; Richard H Karas
Estrogen and the blood vessel wall.
Current opinion in cardiology 1994;9(5):619-26.
1994: Richard H Karas; B L Patterson; M E Mendelsohn
Human vascular smooth muscle cells contain functional estrogen receptor.
Circulation 1994;89(5):1943-50.
1992: W D Funk; D T Pak; Richard H Karas; Woodring E Wright; Jerry W Shay
A transcriptionally active DNA-binding site for human p53 protein complexes.
Molecular and cellular biology 1992;12(6):2866-71.
1991: Richard H Karas; R Sanders Williams
Molecular mechanisms of skeletal muscle adaptations to exercise.
Trends in cardiovascular medicine 1991;1(8):341-6.