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Leonid Karawajew

Research Profile

Procedures

Chemicals & Drugs

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Anatomy

Tumor Cells, Cultured

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Infants

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Giuseppe Gaipa; Leonid Karawajew; Wolf-Dieter Ludwig; Oscar Maglia; Renate Panzer-Grümayer; Richard Ratei; Simona Sala; Martin Schrappe; André Schrauder; Angela Schumich; Daniela Silvestri; Maria Grazia Valsecchi; Marinella Veltroni; Tiziana Villa; Alessandra Benetello; Andrea Biondi; Barbara Buldini; Giovanni Cazzaniga; Valentino Conter; Michael Dworzak; Giuseppe Basso
Time point-dependent concordance of flow cytometry and real-time quantitative polymerase chain reaction for minimal residual disease detection in childhood acute lymphoblastic leukemia.
Jana Hof; Leonid Karawajew; Cornelia Eckert; Christian Hagemeier; Günter Henze; Gabriele Körner; Stefanie Krentz; Wolf-Dieter Ludwig; Peter Rhein; Karl Seeger; Shabnam Shalapour; Claudia van Schewick; Arend von Stackelberg; Renate Kirschner-Schwabe
Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia.
Peter Rhein; Rita Mitlohner; Giuseppe Basso; Giuseppe Gaipa; Michael N Dworzak; Renate Kirschner-Schwabe; Christian Hagemeier; Martin Stanulla; Martin Schrappe; Wolf-Dieter Ludwig; Leonid Karawajew; Richard Ratei
CD11b is a therapy resistance- and minimal residual disease-specific marker in precursor B-cell acute lymphoblastic leukemia.

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All Publications

2012: Giuseppe Gaipa; Leonid Karawajew; Wolf-Dieter Ludwig; Oscar Maglia; Renate Panzer-Grümayer; Richard Ratei; Simona Sala; Martin Schrappe; André Schrauder; Angela Schumich; Daniela Silvestri; Maria Grazia Valsecchi; Marinella Veltroni; Tiziana Villa; Alessandra Benetello; Andrea Biondi; Barbara Buldini; Giovanni Cazzaniga; Valentino Conter; Michael Dworzak; Giuseppe Basso
Time point-dependent concordance of flow cytometry and real-time quantitative polymerase chain reaction for minimal residual disease detection in childhood acute lymphoblastic leukemia.
Haematologica 2012;97(10):1582-93.
2011: Jana Hof; Leonid Karawajew; Cornelia Eckert; Christian Hagemeier; Günter Henze; Gabriele Körner; Stefanie Krentz; Wolf-Dieter Ludwig; Peter Rhein; Karl Seeger; Shabnam Shalapour; Claudia van Schewick; Arend von Stackelberg; Renate Kirschner-Schwabe
Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(23):3185-93.
2010: Peter Rhein; Rita Mitlohner; Giuseppe Basso; Giuseppe Gaipa; Michael N Dworzak; Renate Kirschner-Schwabe; Christian Hagemeier; Martin Stanulla; Martin Schrappe; Wolf-Dieter Ludwig; Leonid Karawajew; Richard Ratei
CD11b is a therapy resistance- and minimal residual disease-specific marker in precursor B-cell acute lymphoblastic leukemia.
Blood 2010;115(18):3763-71.
2010: Michael Dworzak; Giuseppe Gaipa; Angela Schumich; Oscar Maglia; Richard Ratei; Marinella Veltroni; Zvenyslava Husak; Giuseppe Basso; Leonid Karawajew; Helmut Gadner; Andrea Biondi
Modulation of antigen expression in B-cell precursor acute lymphoblastic leukemia during induction therapy is partly transient: evidence for a drug-induced regulatory phenomenon. Results of the AIEOP-BFM-ALL-FLOW-MRD-Study Group.
Cytometry. Part B, Clinical cytometry 2010;78(3):147-53.
2009: Richard Ratei; G Basso; M Dworzak; G Gaipa; M Veltroni; Peter Rhein; A Biondi; Martin Schrappe; Wolf-Dieter Ludwig; Leonid Karawajew
Monitoring treatment response of childhood precursor B-cell acute lymphoblastic leukemia in the AIEOP-BFM-ALL 2000 protocol with multiparameter flow cytometry: predictive impact of early blast reduction on the remission status after induction.
Leukemia 2009;23(3):528-34.
2008: Michael Norbert Dworzak; Giuseppe Gaipa; Richard Ratei; Marinella Veltroni; Angela Schumich; Oscar Maglia; Leonid Karawajew; Allessandra Benetello; Ulrike Pötschger; Zvenyslava Husak; Helmut Gadner; Andrea Biondi; Wolf-Dieter Ludwig; Giuseppe Basso
Standardization of flow cytometric minimal residual disease evaluation in acute lymphoblastic leukemia: Multicentric assessment is feasible.
Cytometry. Part B, Clinical cytometry 2008;74(6):331-40.
2008: Doris Steinemann; Gunnar Cario; Martin Stanulla; Leonid Karawajew; Marcel Tauscher; Anja Weigmann; Gudrun Göhring; Wolf-Dieter Ludwig; Jochen Harbott; Bernhard Radlwimmer; Claus Bartram; Peter Lichter; Martin Schrappe; Brigitte Schlegelberger
Copy number alterations in childhood acute lymphoblastic leukemia and their association with minimal residual disease.
Genes, chromosomes & cancer 2008;47(6):471-80.
2008: Richard Ratei; Leonid Karawajew; Richard Schabath; Angelika Ehrfeldt; Fritz Grunert; Wolf-Dieter Ludwig
Differential expression of the carcinoembryonic antigen-related cell adhesion molecules panCD66, CD66a, CD66c and of sialyl-Lewis x (CD15s) on blast cells of acute leukemias.
International journal of hematology 2008;87(2):137-43.
2008: Lüder Hinrich Meyer; Manon Queudeville; Sarah M Eckhoff; Ursula Creutzig; Dirk Reinhardt; Leonid Karawajew; Wolf-Dieter Ludwig; Karsten Stahnke; Klaus-Michael Debatin
Intact apoptosis signaling in myeloid leukemia cells determines treatment outcome in childhood AML.
Blood 2008;111(5):2899-903.
2007: Gunnar Cario; Shai Izraeli; Anja Teichert; Peter Rhein; Julia Skokowa; Anja Möricke; Martin Zimmermann; André Schrauder; Leonid Karawajew; Wolf-Dieter Ludwig; Karl Welte; Holger J Schünemann; Brigitte Schlegelberger; Martin Schrappe; Martin Stanulla
High interleukin-15 expression characterizes childhood acute lymphoblastic leukemia with involvement of the CNS.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(30):4813-20.
2007: Richard Ratei; Leonid Karawajew; Francis Lacombe; K Jagoda; Giovanni Del Poeta; Jaco Kraan; M De Santiago; János Kappelmayer; E Björklund; Wolf-Dieter Ludwig; Jan W Gratama; Alberto Orfao
Discriminant function analysis as decision support system for the diagnosis of acute leukemia with a minimal four color screening panel and multiparameter flow cytometry immunophenotyping.
Leukemia 2007;21(6):1204-11.
2007: Peter Rhein; Stefanie Scheid; Richard Ratei; Christian Hagemeier; Karl Seeger; Renate Kirschner-Schwabe; A Moericke; Martin Schrappe; Rainer Spang; Wolf-Dieter Ludwig; Leonid Karawajew
Gene expression shift towards normal B cells, decreased proliferative capacity and distinct surface receptors characterize leukemic blasts persisting during induction therapy in childhood acute lymphoblastic leukemia.
Leukemia 2007;21(5):897-905.
2006: Edgar Grinstein; Ying Shan; Leonid Karawajew; Peter J F Snijders; Chris J L M Meijer; hans-dieter royer; Peter Wernet
Cell cycle-controlled interaction of nucleolin with the retinoblastoma protein and cancerous cell transformation.
The Journal of biological chemistry 2006;281(31):22223-35.
2006: Renate Kirschner-Schwabe; Claudio Lottaz; Jörn Tödling; Peter Rhein; Leonid Karawajew; Cornelia Eckert; Arend von Stackelberg; Ute Ungethüm; Dennis Kostka; Andreas E Kulozik; Wolf-Dieter Ludwig; Günter Henze; Rainer Spang; Christian Hagemeier; Karl Seeger
Expression of late cell cycle genes and an increased proliferative capacity characterize very early relapse of childhood acute lymphoblastic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4553-61.
2006: Lüder Hinrich Meyer; Leonid Karawajew; Martin Schrappe; Wolf-Dieter Ludwig; Klaus-Michael Debatin; Karsten Stahnke
Cytochrome c-related caspase-3 activation determines treatment response and relapse in childhood precursor B-cell ALL.
Blood 2006;107(11):4524-31.
2006: Joern Toedling; Peter Rhein; Richard Ratei; Leonid Karawajew; Rainer Spang
Automated in-silico detection of cell populations in flow cytometry readouts and its application to leukemia disease monitoring.
BMC bioinformatics 2006;7():282.
2006: Richard Ratei; Leonid Karawajew; Francis Lacombe; Krystyna Jagoda; Giovanni Del Poeta; Jaco Kraan; Maria De Santiago; János Kappelmayer; Elisabeth Björklund; Wolf-Dieter Ludwig; Jan W Gratama; Alberto Orfao
Normal lymphocytes from leukemic samples as an internal quality control for fluorescence intensity in immunophenotyping of acute leukemias.
Cytometry. Part B, Clinical cytometry 2006;70(1):1-9.
2005: Leonid Karawajew; Peter Rhein; Grit Czerwony; Wolf-Dieter Ludwig
Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species.
Blood 2005;105(12):4767-75.
2004: Karsten Stahnke; A Mohr; J Liu; Lüder Hinrich Meyer; Leonid Karawajew; Klaus-Michael Debatin
Identification of deficient mitochondrial signaling in apoptosis resistant leukemia cells by flow cytometric analysis of intracellular cytochrome c, caspase-3 and apoptosis.
Apoptosis : an international journal on programmed cell death 2004;9(4):457-65.
2004: Ingo Tamm; Stephan Richter; Doreen Oltersdorf; Ursula Creutzig; Jochen Harbott; Frank Scholz; Leonid Karawajew; Wolf-Dieter Ludwig; Christian Wuchter
High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(11):3737-44.
2004: Christian Wuchter; Stephan Richter; Doreen Oltersdorf; Leonid Karawajew; Wolf-Dieter Ludwig; Ingo Tamm
Differences in the expression pattern of apoptosis-related molecules between childhood and adult de novo acute myeloid leukemia.
Haematologica 2004;89(3):363-4.
2004: Ingo Tamm; Stephan Richter; Frank Scholz; Karin Schmelz; Doreen Oltersdorf; Leonid Karawajew; Claudia Schoch; Torsten Haferlach; Wolf-Dieter Ludwig; Christian Wuchter
XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5(6):489-95.
2003: Alexei N Veselkov; Vladimir Ya Maleev; Evgenie N Glibin; Leonid Karawajew; David B Davies
Structure-activity relation for synthetic phenoxazone drugs: evidence for a direct correlation between DNA and pro-apoptotic activity.
European journal of biochemistry / FEBS 2003;270(20):4200-7.
2003: A Löffler; M Gruen; Christian Wuchter; F Schriever; Peter Kufer; Torsten Dreier; Frank Hanakam; Patrick A Baeuerle; Kurt Bommert; Leonid Karawajew; Bernd Dörken; Ralf C Bargou
Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct.
Leukemia 2003;17(5):900-9.
2003: Gerhard Wolff; A Schumacher; A K Nuessler; Velia Ruppert; Leonid Karawajew; E Wehnes; P Neuhaus; Bernd Dörken
Coexpression of p21(WAF1/CIP1) in adenovirus vector transfected human primary hepatocytes prevents apoptosis resulting in improved transgene expression.
Gene therapy 2003;10(8):668-77.
2002: Ingo Tamm; Axel Schumacher; Leonid Karawajew; Velia Ruppert; Wolfgang Arnold; Andreas K Nüssler; Peter Neuhaus; Bernd Dörken; Gerhard Wolff
Adenovirus-mediated gene transfer of P16INK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo.
Cancer gene therapy 2002;9(8):641-50.
2002: Christian Wuchter; Velia Ruppert; Martin Schrappe; Bernd Dörken; Wolf-Dieter Ludwig; Leonid Karawajew
In vitro susceptibility to dexamethasone- and doxorubicin-induced apoptotic cell death in context of maturation stage, responsiveness to interleukin 7, and early cytoreduction in vivo in childhood T-cell acute lymphoblastic leukemia.
Blood 2002;99(11):4109-15.
2002: Hartmut Kuhn; Uta Liebers; Christian Gessner; Leonid Karawajew; Velia Ruppert; Axel Schumacher; Christian Witt; Gerhard Wolff
Infection of cells with replication deficient adenovirus induces cell cycle alterations and leads to downregulation of E2F-1.
Biochimica et biophysica acta 2002;1542(1-3):106-15.
2002: Udo Zacharzowsky; Gerhard Wolff; Monika Kott; Hannelore Haase; Holger Bartsch; Andreas K Nuessler; Leonidas G Baltas; Leonid Karawajew; Ingo Morano
Analysis of the energetic state of heart cells after adenovirus-mediated expression of hALC-1.
Journal of cellular biochemistry 2002;86(3):422-31.
2001: Christian Wuchter; Daniel Krappmann; Zhen Cai; Velia Ruppert; Claus Scheidereit; Bernd Dörken; Wolf-Dieter Ludwig; Leonid Karawajew
In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kappa B activity.
Leukemia 2001;15(6):921-8.
2001: Zhen Cai; Maofang Lin; Wolf-Dieter Ludwig; Leonid Karawajew
[Involvement of mitochondrial membrane potential in the homoharringtonine induced apoptosis of leukemic T-cells].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2001;22(5):238-40.
2001: Zhen Cai; M Lin; Christian Wuchter; Velia Ruppert; Bernd Dörken; Wolf-Dieter Ludwig; Leonid Karawajew
Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation.
Leukemia 2001;15(4):567-74.
2001: Christian Wuchter; Richard Ratei; G Spahn; Claudia Schoch; Jochen Harbott; Susanne Schnittger; Torsten Haferlach; U Creutzig; C Sperling; Leonid Karawajew; Wolf-Dieter Ludwig
Impact of CD133 (AC133) and CD90 expression analysis for acute leukemia immunophenotyping.
Haematologica 2001;86(2):154-61.
2000: Leonid Karawajew; E N Glibin; V Y Maleev; G Czerwony; Bernd Dörken; David B Davies; Alexei N Veselkov
Role of crown-like side chains in the biological activity of substituted-phenoxazone drugs.
Anti-cancer drug design 2000;15(5):331-8.
2000: Christian Wuchter; Leonid Karawajew; Velia Ruppert; Martin Schrappe; Jochen Harbott; Richard Ratei; Bernd Dörken; Wolf-Dieter Ludwig
Constitutive expression levels of CD95 and Bcl-2 as well as CD95 function and spontaneous apoptosis in vitro do not predict the response to induction chemotherapy and relapse rate in childhood acute lymphoblastic leukaemia.
British journal of haematology 2000;110(1):154-60.
2000: Christian Wuchter; Jochen Harbott; Claudia Schoch; Susanne Schnittger; Arndt Borkhardt; Leonid Karawajew; Richard Ratei; Velia Ruppert; Torsten Haferlach; U Creutzig; Bernd Dörken; Wolf-Dieter Ludwig
Detection of acute leukemia cells with mixed lineage leukemia (MLL) gene rearrangements by flow cytometry using monoclonal antibody 7.1.
Leukemia 2000;14(7):1232-8.
2000: Leonid Karawajew; Velia Ruppert; Christian Wuchter; A Kösser; Martin Schrappe; Bernd Dörken; Wolf-Dieter Ludwig
Inhibition of in vitro spontaneous apoptosis by IL-7 correlates with bcl-2 up-regulation, cortical/mature immunophenotype, and better early cytoreduction of childhood T-cell acute lymphoblastic leukemia.
Blood 2000;96(1):297-306.
1999: Christian Wuchter; Leonid Karawajew; Velia Ruppert; Thomas Büchner; Claudia Schoch; Torsten Haferlach; Richard Ratei; Bernd Dörken; Wolf-Dieter Ludwig
Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, maturation stage, and cytogenetics.
Leukemia 1999;13(12):1943-53.
1998: Richard Ratei; C Sperling; Leonid Karawajew; G Schott; Martin Schrappe; Jochen Harbott; Hansjörg Riehm; Wolf-Dieter Ludwig
Immunophenotype and clinical characteristics of CD45-negative and CD45-positive childhood acute lymphoblastic leukemia.
Annals of hematology 1998;77(3):107-14.
1997: Leonid Karawajew; Christian Wuchter; Velia Ruppert; H Drexler; H J Gruss; Bernd Dörken; Wolf-Dieter Ludwig
Differential CD95 expression and function in T and B lineage acute lymphoblastic leukemia cells.
Leukemia 1997;11(8):1245-52.
1996: David B Davies; Leonid Karawajew; Alexei N Veselkov
1H-NMR structural analysis of ethidium bromide complexation with self-complementary deoxytetranucleotides 5'-d(ApCpGpT), 5'-d(ApGpCpT), and 5'-d(TpGpCpA) in aqueous solution.
Biopolymers 1996;38(6):745-57.
1996: Ralf R Schumann; Dagmar Pfeil; Norbert Lamping; Carsten J Kirschning; G Scherzinger; P Schlag; Leonid Karawajew; F Herrmann
Lipopolysaccharide induces the rapid tyrosine phosphorylation of the mitogen-activated protein kinases erk-1 and p38 in cultured human vascular endothelial cells requiring the presence of soluble CD14.
Blood 1996;87(7):2805-14.
1996: Ralf R Schumann; T Nakarai; HJ Gruss; M A Brach; U von Arnim; Carsten J Kirschning; Leonid Karawajew; Wolf-Dieter Ludwig; J C Renauld; Jerome Ritz; F Herrmann
Transcript synthesis and surface expression of the interleukin-2 receptor (alpha-, beta-, and gamma-chain) by normal and malignant myeloid cells.
Blood 1996;87(6):2419-27.
1995: Leonid Karawajew; Alexei N Veselkov; F Herrmann
Submitogenic concentrations of anti-CD3 monoclonal antibody exert antiapoptotic effects in preactivated CD4+ but not CD8+ human T cells.
Cytokines and molecular therapy 1995;1(4):271-9.
1995: S R Goan; Iduna Fichtner; U Just; Leonid Karawajew; W Schultze; K P Krause; S von Harsdorf; C von Schilling; F Herrmann
The severe combined immunodeficient-human peripheral blood stem cell (SCID-huPBSC) mouse: a xenotransplant model for huPBSC-initiated hematopoiesis.
Blood 1995;86(1):89-100.
1994: M Kiehntopf; M A Brach; T Licht; S Petschauer; Leonid Karawajew; Carsten J Kirschning; F Herrmann
Ribozyme-mediated cleavage of the MDR-1 transcript restores chemosensitivity in previously resistant cancer cells.
The EMBO journal 1994;13(19):4645-52.
1994: C Sott; B Dorner; Leonid Karawajew; F Herrmann; M A Brach
Transforming growth factor-beta relieves stem cell factor-induced proliferation of myelogenous leukemia cells through inhibition of binding of the transcription factor NF-jun.
Blood 1994;84(6):1950-9.