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Peter Karczewski

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Anatomy

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Myocardial Contraction

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Peter Karczewski; R Kunze; P Hempel; M Bimmler
Agonistic autoantibodies to the α(1) -adrenergic receptor and the β(2) -adrenergic receptor in Alzheimer's and vascular dementia.
Peter Karczewski; Rudolf Kunze; Bernd Lemke; Thoralf Niendorf; Andreas Pohlmann; Babette Wagenhaus; Natali Wisbrun; P Hempel; Marion Bimmler
Antibodies to the α1-adrenergic receptor cause vascular impairments in rat brain as demonstrated by magnetic resonance angiography.
Peter Karczewski; Hannelore Haase; Petra Hempel; Marion Bimmler
Agonistic antibody to the alpha1-adrenergic receptor mobilizes intracellular calcium and induces phosphorylation of a cardiac 15-kDa protein.

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All Publications

2012: Peter Karczewski; R Kunze; P Hempel; M Bimmler
Agonistic autoantibodies to the α(1) -adrenergic receptor and the β(2) -adrenergic receptor in Alzheimer's and vascular dementia.
Scandinavian journal of immunology 2012;75(5):524-30.
2012: Peter Karczewski; Rudolf Kunze; Bernd Lemke; Thoralf Niendorf; Andreas Pohlmann; Babette Wagenhaus; Natali Wisbrun; P Hempel; Marion Bimmler
Antibodies to the α1-adrenergic receptor cause vascular impairments in rat brain as demonstrated by magnetic resonance angiography.
PloS one 2012;7(7):e41602.
2010: Peter Karczewski; Hannelore Haase; Petra Hempel; Marion Bimmler
Agonistic antibody to the alpha1-adrenergic receptor mobilizes intracellular calcium and induces phosphorylation of a cardiac 15-kDa protein.
Molecular and cellular biochemistry 2010;333(1-2):233-42.
2008: Katrin Wenzel; Hannelore Haase; Gerd Wallukat; Wolfgang Derer; Sabine Bartel; Volker Homuth; Florian Herse; Norbert Hubner; Herbert Schulz; Marion Janczikowski; Carsten Lindschau; Christoph Schroeder; Stefan Verlohren; Ingo Morano; Dominik N Muller; Friedrich C Luft; Rainer Dietz; Ralf Dechend; Peter Karczewski
Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension.
PloS one 2008;3(11):e3742.
2007: Gisela Lättig-Tünnemann; Peter Karczewski; Hannelore Haase; M Cristina Cardoso; Ingo Morano
Modulation of muscle contraction by a cell-permeable peptide.
Journal of molecular medicine (Berlin, Germany) 2007;85(12):1405-12.
2006: Valéria Lamounier-Zepter; Monika Ehrhart-Bornstein; Peter Karczewski; Hannelore Haase; Stefan R Bornstein; Ingo Morano
Human adipocytes attenuate cardiomyocyte contraction: characterization of an adipocyte-derived negative inotropic activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(10):1653-9.
2006: Hannelore Haase; Gisela Dobbernack; Gisela Lättig-Tünnemann; Peter Karczewski; Cristina Cardoso; Daria Petzhold; Wolfgang-Peter Schlegel; Steffen Lutter; Petra Pierschalek; Joachim Behlke; Ingo Morano
Minigenes encoding N-terminal domains of human cardiac myosin light chain-1 improve heart function of transgenic rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(7):865-73.
2005: Christiane Woischwill; Peter Karczewski; Holger Bartsch; Hans Peter Luther; Monika Kott; Hannelore Haase; Ingo Morano
Regulation of the human atrial myosin light chain 1 promoter by Ca2+-calmodulin-dependent signaling pathways.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(6):503-11.
2004: Jan Slezak; Igor B Buchwalow; Wolfgang Schulze; Peter Karczewski; Gerd Wallukat; Vera E Samoilova; Ernst-Georg Krause; Joachim Neumann; Hermann Haller
Cellular control of nitric oxide synthase expression and activity in rat cardiomyocytes.
Antioxidants & redox signaling 2004;6(2):345-52.
2003: Sabine Bartel; Ernst-Georg Krause; Gerd Wallukat; Peter Karczewski
New insights into beta2-adrenoceptor signaling in the adult rat heart.
Cardiovascular research 2003;57(3):694-703.
2002: Zsolt Balla; Brigitte Hoch; Peter Karczewski; Ingolf E Blasig
Calcium/calmodulin-dependent protein kinase IIdelta 2 and gamma isoforms regulate potassium currents of rat brain capillary endothelial cells under hypoxic conditions.
The Journal of biological chemistry 2002;277(24):21306-14.
2002: Götz Münch; Birgit Bölck; Peter Karczewski; Robert H G Schwinger
Evidence for calcineurin-mediated regulation of SERCA 2a activity in human myocardium.
Journal of molecular and cellular cardiology 2002;34(3):321-34.
2002: P Hempel; Brigitte Hoch; Sabine Bartel; Peter Karczewski
Hypertrophic phenotype of cardiac calcium/calmodulin-dependent protein kinase II is reversed by angiotensin converting enzyme inhibition.
Basic research in cardiology 2002;97 Suppl 1():I96-101.
2001: D Hagemann; Jürgen Bohlender; Brigitte Hoch; Ernst-Georg Krause; Peter Karczewski
Expression of Ca2+/calmodulin-dependent protein kinase II delta-subunit isoforms in rats with hypertensive cardiac hypertrophy.
Molecular and cellular biochemistry 2001;220(1-2):69-76.
2001: Igor B Buchwalow; Wolfgang Schulze; Peter Karczewski; MM Kostic; Gerd Wallukat; Rosemarie Morwinski; Ernst-Georg Krause; J Müller; Martin Paul; Jan Slezak; F C Luft; H Haller
Inducible nitric oxide synthase in the myocard.
Molecular and cellular biochemistry 2001;217(1-2):73-82.
2000: Sabine Bartel; Donathe Vetter; Wolfgang-Peter Schlegel; Gerd Wallukat; Ernst-Georg Krause; Peter Karczewski
Phosphorylation of phospholamban at threonine-17 in the absence and presence of beta-adrenergic stimulation in neonatal rat cardiomyocytes.
Journal of molecular and cellular cardiology 2000;32(12):2173-85.
2000: Peter Molenaar; Sabine Bartel; A Cochrane; Donathe Vetter; H Jalali; Peter G Pohlner; KM Burrell; Peter Karczewski; Ernst-Georg Krause; Alberto J Kaumann
Both beta(2)- and beta(1)-adrenergic receptors mediate hastened relaxation and phosphorylation of phospholamban and troponin I in ventricular myocardium of Fallot infants, consistent with selective coupling of beta(2)-adrenergic receptors to G(s)-protein.
Circulation 2000;102(15):1814-21.
2000: Brigitte Hoch; A M Wobus; Ernst-Georg Krause; Peter Karczewski
delta-Ca(2+)/calmodulin-dependent protein kinase II expression pattern in adult mouse heart and cardiogenic differentiation of embryonic stem cells.
Journal of cellular biochemistry 2000;79(2):293-300.
1999: Sophie Tessier; Peter Karczewski; Ernst-Georg Krause; Y Pansard; C Acar; M Lang-Lazdunski; Jean-Jacques Mercadier; Stéphane N Hatem
Regulation of the transient outward K(+) current by Ca(2+)/calmodulin-dependent protein kinases II in human atrial myocytes.
Circulation research 1999;85(9):810-9.
1999: D Hagemann; Brigitte Hoch; Ernst-Georg Krause; Peter Karczewski
Developmental changes in isoform expression of Ca2+/calmodulin-dependent protein kinase II delta-subunit in rat heart.
Journal of cellular biochemistry 1999;74(2):202-10.
1999: Meike Kuschel; Ying-Ying Zhou; Harold A Spurgeon; Sabine Bartel; Peter Karczewski; Sheng-Jun Zhang; Ernst-Georg Krause; Edward G Lakatta; Rui-Ping Xiao
beta2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart.
Circulation 1999;99(18):2458-65.
1999: Meike Kuschel; Peter Karczewski; P Hempel; Wolfgang-Peter Schlegel; Ernst-Georg Krause; Sabine Bartel
Ser16 prevails over Thr17 phospholamban phosphorylation in the beta-adrenergic regulation of cardiac relaxation.
The American journal of physiology 1999;276(5 Pt 2):H1625-33.
1999: Brigitte Hoch; R Meyer; Roland Hetzer; Ernst-Georg Krause; Peter Karczewski
Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium.
Circulation research 1999;84(6):713-21.
1999: Robert H G Schwinger; Götz Münch; Birgit Bölck; Peter Karczewski; Ernst-Georg Krause; Erland Erdmann
Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation.
Journal of molecular and cellular cardiology 1999;31(3):479-91.
1999: Alberto J Kaumann; Sabine Bartel; Peter Molenaar; L Sanders; KM Burrell; Donathe Vetter; P Hempel; Peter Karczewski; Ernst-Georg Krause
Activation of beta2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure.
Circulation 1999;99(1):65-72.
1999: Joachim Neumann; Sabine Bartel; T Eschenhagen; A Haverich; S Hirt; Peter Karczewski; Ernst-Georg Krause; Wilhelm Schmitz; H Scholz; B Stein; M Thoenes
Dissociation of the effects of forskolin and dibutyryl cAMP on force of contraction and phospholamban phosphorylation in human heart failure.
Journal of cardiovascular pharmacology 1999;33(1):157-62.
1998: Peter Karczewski; T Hendrischke; W P Wolf; Ingo Morano; Sabine Bartel; J Schrader
Phosphorylation of phospholamban correlates with relaxation of coronary artery induced by nitric oxide, adenosine, and prostacyclin in the pig.
Journal of cellular biochemistry 1998;70(1):49-59.
1998: Brigitte Hoch; Hannelore Haase; Wolfgang Schulze; D Hagemann; Ingo Morano; Ernst-Georg Krause; Peter Karczewski
Differentiation-dependent expression of cardiac delta-CaMKII isoforms.
Journal of cellular biochemistry 1998;68(2):259-68.
1997: Leonidas G Baltas; Peter Karczewski; Sabine Bartel; Ernst-Georg Krause
The endogenous cardiac sarcoplasmic reticulum Ca2+/calmodulin-dependent kinase is activated in response to beta-adrenergic stimulation and becomes Ca2+-independent in intact beating hearts.
FEBS letters 1997;409(2):131-6.
1997: Leonidas G Baltas; Peter Karczewski; Ernst-Georg Krause
Effects of zinc on phospholamban phosphorylation.
Biochemical and biophysical research communications 1997;232(2):394-7.
1997: Peter Karczewski; Meike Kuschel; Leonidas G Baltas; Sabine Bartel; Ernst-Georg Krause
Site-specific phosphorylation of a phospholamban peptide by cyclic nucleotide- and Ca2+/calmodulin-dependent protein kinases of cardiac sarcoplasmic reticulum.
Basic research in cardiology 1997;92 Suppl 1():37-43.
1996: A J Kaumann; L Sanders; J A Lynham; Sabine Bartel; Meike Kuschel; Peter Karczewski; Ernst-Georg Krause
Beta 2-adrenoceptor activation by zinterol causes protein phosphorylation, contractile effects and relaxant effects through a cAMP pathway in human atrium.
Molecular and cellular biochemistry 1996;163-164():113-23.
1996: Hannelore Haase; Sabine Bartel; Peter Karczewski; Ingo Morano; Ernst-Georg Krause
In-vivo phosphorylation of the cardiac L-type calcium channel beta-subunit in response to catecholamines.
Molecular and cellular biochemistry 1996;163-164():99-106.
1996: Sabine Bartel; Peter Karczewski; Ernst-Georg Krause
G proteins, adenylyl cyclase and related phosphoproteins in the developing rat heart.
Molecular and cellular biochemistry 1996;163-164():31-8.
1996: Brigitte Hoch; Gudrun Lutsch; W P Schlegel; J Stahl; Gerd Wallukat; Sabine Bartel; Ernst-Georg Krause; Rainer Benndorf; Peter Karczewski
HSP25 in isolated perfused rat hearts: localization and response to hyperthermia.
Molecular and cellular biochemistry 1996;160-161():231-9.
1996: Sabine Bartel; B Stein; Thomas Eschenhagen; U Mende; J Neumann; W Schmitz; Ernst-Georg Krause; Peter Karczewski; H Scholz
Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts.
Molecular and cellular biochemistry 1996;157(1-2):171-9.
1995: Leonidas G Baltas; Peter Karczewski; Ernst-Georg Krause
The cardiac sarcoplasmic reticulum phospholamban kinase is a distinct delta-CaM kinase isozyme.
FEBS letters 1995;373(1):71-5.
1995: B Sabine; R Willenbrock; Hannelore Haase; Peter Karczewski; Gerd Wallukat; R Dietz; Ernst-Georg Krause
Cyclic GMP-mediated phospholamban phosphorylation in intact cardiomyocytes.
Biochemical and biophysical research communications 1995;214(1):75-80.
1995: Sabine Bartel; Peter Karczewski; Ingo Morano; Ernst-Georg Krause
Function of C-protein and troponin I phosphorylation in the heart.
Annals of the New York Academy of Sciences 1995;752():243-5.
1994: Sabine Bartel; Ingo Morano; H D Hunger; H Katus; H T Pask; Peter Karczewski; Ernst-Georg Krause
Cardiac troponin I and tension generation of skinned fibres in the developing rat heart.
Journal of molecular and cellular cardiology 1994;26(9):1123-31.
1993: Hannelore Haase; Peter Karczewski; R Beckert; Ernst-Georg Krause
Phosphorylation of the L-type calcium channel beta subunit is involved in beta-adrenergic signal transduction in canine myocardium.
FEBS letters 1993;335(2):217-22.
1993: Sabine Bartel; Peter Karczewski; Ernst-Georg Krause
Protein phosphorylation and cardiac function: cholinergic-adrenergic interaction.
Cardiovascular research 1993;27(11):1948-53.
1993: Peter Karczewski; Sabine Bartel; Ernst-Georg Krause
Protein phosphorylation in the regulation of cardiac contractility and vascular smooth muscle tone.
Current opinion in nephrology and hypertension 1993;2(1):33-40.
1990: Peter Karczewski; Sabine Bartel; Ernst-Georg Krause
Differential sensitivity to isoprenaline of troponin I and phospholamban phosphorylation in isolated rat hearts.
The Biochemical journal 1990;266(1):115-22.
1989: Sabine Bartel; Peter Karczewski; Ernst-Georg Krause
Phosphorylation of phospholamban and troponin I in the ischemic and reperfused heart: attenuation and restoration of isoprenaline responsiveness.
Biomedica biochimica acta 1989;48(2-3):S108-13.
1987: Peter Karczewski; Sabine Bartel; Hannelore Haase; Ernst-Georg Krause
Isoproterenol induces both cAMP- and calcium-dependent phosphorylation of phospholamban in canine heart in vivo.
Biomedica biochimica acta 1987;46(8-9):S433-9.
1986: Sabine Bartel; Ernst-Georg Krause; Peter Karczewski
Metabolic and contractile changes in ischaemic rat hearts after isoproterenol administration: effect of reperfusion.
Biomedica biochimica acta 1986;45(1-2):S215-8.
1983: Ernst-Georg Krause; Sabine Bartel; Peter Karczewski; K F Lindenau
Cyclic nucleotides and changes in protein kinase activity ratio in the ischemic and nonischemic myocardium.
Advances in myocardiology 1983;4():521-30.