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Michael Karin

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TOP 3
Weizhou Zhang; Nicholas Borcherding; Majid Ghassemian; Wei Li; Maxim Poustovoitov; Amy Strasner; Wei Tan; Xuefeng Wu; Michael Karin
A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1.
Ning Li; Jorge Moscat; Hisanobu Ogata; Eek Joong Park; Donald P Pizzo; David Tarin; Jelena Todoric; Scott Vandenberg; Xuefeng Wu; Melek C Arkan; Ciǧdem Atay; David Dawson; Thomas J Deerinck; Maria Diaz-Meco; Mert Erkan; Anna S Gukovskaya; Ilya Gukovsky; Ryan G Holzer; Jörg Kleeff; Jun-Hee Lee; Michael Karin
Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice.
Kepeng Wang; Sergei I Grivennikov; Michael Karin
Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases.

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All Publications

2013: Weizhou Zhang; Nicholas Borcherding; Majid Ghassemian; Wei Li; Maxim Poustovoitov; Amy Strasner; Wei Tan; Xuefeng Wu; Michael Karin
A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1.
Cancer cell 2013;23(5):647-59.
2013: Ning Li; Jorge Moscat; Hisanobu Ogata; Eek Joong Park; Donald P Pizzo; David Tarin; Jelena Todoric; Scott Vandenberg; Xuefeng Wu; Melek C Arkan; Ciǧdem Atay; David Dawson; Thomas J Deerinck; Maria Diaz-Meco; Mert Erkan; Anna S Gukovskaya; Ilya Gukovsky; Ryan G Holzer; Jörg Kleeff; Jun-Hee Lee; Michael Karin
Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice.
The Journal of clinical investigation 2013;123(5):2231-43.
2013: Kepeng Wang; Sergei I Grivennikov; Michael Karin
Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases.
Annals of the rheumatic diseases 2013;72 Suppl 2():ii100-3.
2013: Alessandra Mancino; Sylvie Memet; Michael Seed; Xuefeng Wu; Lionel Luron; Marc Bajenoff; Magali Bebien; Jorge Caamano; Hongbo Chi; Carol Fong; Mohamed Habbeddine; Ella Johnson; Michael Karin; Toby Lawrence
I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection.
The EMBO journal 2013;32(6):816-28.
2012: Sergei I Grivennikov; Kenneth E Hung; Dominik Jauch; Hilde Cheroutre; Vincenzo Coppola; Christian Datz; Lars Eckmann; Eric R Fearon; Ying Feng; Daniel Mucida; Christoph H Osterreicher; Mohamed Oukka; Bernd Schnabl; C Andrew Stewart; Koji Taniguchi; Lino Tessarollo; Giorgio Trinchieri; Kepeng Wang; Felix Yarovinsky; Guann-Yi Yu; Michael Karin
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Nature 2012;491(7423):254-8.
2012: Guann-Yi Yu; Sergei Grivennikov; Guobin He; Chih-Wen Hsu; Chia-Yang Li; Martin Tang; Wan-Ting Tsai; Yu Tsai; Lily Hui-Ching Wang; Ming-Sian Wu; Michael Karin
Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production.
Molecular cell 2012;48(2):313-21.
2012: Jun Hee Lee; Ning Li; Jerrold Olefsky; Eek Joong Park; Hae Li Park; Hwan-Woo Park; Guy A Perkins; Miriam Scadeng; Saswata Talukdar; Benoit Viollet; Amber M Wolfe; Mariam Aghajan; Gautam Bandyopadhyay; Ethan Bier; Andrei V Budanov; Mark H Ellisman; Marc Foretz; Insook Jang; Michael Karin
Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.
Cell metabolism 2012;16(3):311-21.
2012: Anthony Gaba; Sergei I Grivennikov; Perry J Blackshear; Mahn Vu Do; Deborah J Stumpo; Michael Karin
Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(5):2089-93.
2012: Monica Guma; Deepa Hammaker; Michael Karin; Katharyn Topolewski; David L Boyle; Maripat Corr; Gary S Firestein
Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6.
Arthritis and rheumatism 2012;64(9):2887-95.
2012: Helena Shaked; Steve Shenouda; Koji Taniguchi; Jin Wang; Yinsheng Wang; Alena Chumanevich; Alexander A Chumanevich; Hans Clevers; Monica Guma; Curtis C Harris; Lorne J Hofseth; Michael Karin
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(35):14007-12.
2012: Ekihiro Seki; David A Brenner; Michael Karin
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches.
Gastroenterology 2012;143(2):307-20.
2012: Joan Font-Burgada; Ekihiro Seki; Michael Karin
CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction.
Cancer cell 2012;21(6):711-2.
2012: Mumtaz Yaseen Balkhi; Zhisong Chen; Denis C Guttridge; Michael Karin; Shuang Liu; Jami Willette-Brown; Feng Zhu; Yinling Hu
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
Blood 2012;119(23):5467-77.
2012: Joseph A DiDonato; Frank Mercurio; Michael Karin
NF-κB and the link between inflammation and cancer.
Immunological reviews 2012;246(1):379-400.
2012: Mariam Aghajan; Ning Li; Michael Karin
Obesity, autophagy and the pathogenesis of liver and pancreatic cancers.
Journal of gastroenterology and hepatology 2012;27 Suppl 2():10-4.
2012: Beicheng Sun; Michael Karin
Obesity, inflammation, and liver cancer.
Journal of hepatology 2012;56(3):704-13.
2012: Mireille Delhase; Michael Karin; Se-Jin Kim; Soo-Youl Kim; Koichi S Kobayashi; Norman Lautsch; Ho Lee; Kazuhiro Murata; Aya Naiki-Ito; Eu-Ree Ahn; Yi Chen; Tomoyuki Shirai; Makoto Nakanishi
TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(4):E177-86.
2012: Magali Bebien; Suzel Davanture; Mary E Hensler; Li-Chung Hsu; Michael Karin; George Y Liu; Victor Nizet; Jin Mo Park; Lena Alexopoulou; Toby Lawrence
The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity.
PLoS pathogens 2012;8(7):e1002812.
2011: Ali Kuraishy; Michael Karin; Sergei I Grivennikov
Tumor promotion via injury- and death-induced inflammation.
Immunity 2011;35(4):467-77.
2011: Ryan G Holzer; Monica Chen; Crystal Choi; Ning Li; Eek Joong Park; Giovanni Solinas; Helen Tran; Michael Karin
Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation.
Cell 2011;147(1):173-84.
2011: John L Stebbins; Li-Hsing Chen; Vida Chen; Surya K De; Michael Karin; Shinichi Kitada; Christian Kuntzen; thomas machleidt; Petra Pavlickova; Maurizio Pellecchia
Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor.
Journal of medicinal chemistry 2011;54(18):6206-14.
2011: Monica Guma; Martin F Kagnoff; Hilde Cheroutre; Lars Eckmann; Helena Shaked; Steve Shenouda; Martina E Spehlmann; Dariusz Stepniak; Ildelfonso Vicente-Suarez; Michael Karin
Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation.
The Journal of experimental medicine 2011;208(9):1889-900.
2011: Elisabetta Botti; Tiziana Castrignanò; Sergio Chimenti; Giovanni Blandino; Paolo D'Onorio De Meo; Francesca De Nicola; Maurizio Fanciulli; Sergio Galanti; Federica Ganci; Luisa Guerrini; Michael Karin; Barbara Marinari; Fabiola Moretti; Graziano Pesole; Valentina Pinetti; Giulia Spallone; Antonio Costanzo
Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):13710-5.
2011: Syed Raza Ali; Sameera Bilgrami; Lars Eckmann; Victor Nizet; Eek Joong Park; Anjuli M Timmer; Michael Karin
Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage.
Immunity 2011;35(1):34-44.
2011: Hans Häcker; Ping-Hui Tseng; Michael Karin
Expanding TRAF function: TRAF3 as a tri-faced immune regulator.
Nature reviews. Immunology 2011;11(7):457-68.
2011: Monica Guma; Lisa M Ronacher; Gary S Firestein; Michael Karin; Maripat Corr
JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis.
Arthritis and rheumatism 2011;63(6):1603-12.
2011: Junghee Kang; Mei Hua Jiang; Hyun Jung Min; Eun-Kyeong Jo; Soojin Lee; Michael Karin; Tae Young Yune; Sung Joong Lee
IKK-β-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury.
European journal of immunology 2011;41(5):1266-77.
2011: Ning Li; Sergei I Grivennikov; Michael Karin
The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment.
Cancer cell 2011;19(4):429-31.
2011: Sergei I Grivennikov; Michael Karin
Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage.
Annals of the rheumatic diseases 2011;70 Suppl 1():i104-8.
2011: Wei Tan; Weizhou Zhang; Amy Strasner; Sergei Grivennikov; Jin Q Cheng; Robert M Hoffman; Michael Karin
Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling.
Nature 2011;470(7335):548-53.
2011: Christoph H Österreicher; Melitta Penz-Österreicher; Sergei I Grivennikov; Monica Guma; Ekaterina K Koltsova; Christian Datz; Roman Sasik; Hardiman Gary; Michael Karin; David A Brenner
Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(1):308-13.
2011: Sunhwa Kim; Michael Karin
Role of TLR2-dependent inflammation in metastatic progression.
Annals of the New York Academy of Sciences 2011;1217():191-206.
2011: Guobin He; Michael Karin
NF-κB and STAT3 - key players in liver inflammation and cancer.
Cell research 2011;21(1):159-68.
2010: Monica Guma; Jun-ichi Kashiwakura; Brian Crain; Yuko Kawakami; Bruce Beutler; Gary S Firestein; Toshiaki Kawakami; Michael Karin; Maripat Corr
JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(51):22122-7.
2010: Weizhou Zhang; Arnon P Kater; George F Widhopf; Han-Yu Chuang; Thomas Enzler; Danelle F James; Maxim Poustovoitov; Ping-Hui Tseng; Siegfried Janz; Carl Hoh; Harvey Herschman; Michael Karin; Thomas Kipps
B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):18956-60.
2010: Florian R Greten; Michael Karin
Peering into the aftermath: JAKi rips STAT3 in cancer.
Nature medicine 2010;16(10):1085-7.
2010: Andrei V Budanov; Jun Hee Lee; Michael Karin
Stressin' Sestrins take an aging fight.
EMBO molecular medicine 2010;2(10):388-400.
2010: Andrew Doedens; Christian Stockmann; Mark P Rubinstein; Debbie Liao; Na Zhang; David G DeNardo; Lisa M Coussens; Michael Karin; Ananda W Goldrath; Randall S Johnson
Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression.
Cancer research 2010;70(19):7465-75.
2010: Sang Yeub Lee; Marina Miller; Jae Youn Cho; Dae Jin Song; Michael Karin; David H Broide
Inactivation of I kappaB-kinase-beta dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation.
International immunopharmacology 2010;10(8):906-12.
2010: Giovanni Solinas; Michael Karin
JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(8):2596-611.
2010: Jun Hee Lee; Rolf Bodmer; Ethan Bier; Michael Karin
Sestrins at the crossroad between stress and aging.
Aging 2010;2(6):369-74.
2010: Janos Terzić; Sergei Grivennikov; Eliad Karin; Michael Karin
Inflammation and colon cancer.
Gastroenterology 2010;138(6):2101-2114.e5.
2010: Sergei I Grivennikov; Florian R Greten; Michael Karin
Immunity, inflammation, and cancer.
Cell 2010;140(6):883-99.
2010: Guobin He; Guann-Yi Yu; Vladislav Temkin; Hisanobu Ogata; Christian Kuntzen; Toshiharu Sakurai; Wolfgang Sieghart; Markus Peck-Radosavljevic; Hyam L Leffert; Michael Karin
Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation.
Cancer cell 2010;17(3):286-97.
2010: Massimo Ammirante; Jun-Li Luo; Sergei Grivennikov; Sergei Nedospasov; Michael Karin
B-cell-derived lymphotoxin promotes castration-resistant prostate cancer.
Nature 2010;464(7286):302-5.
2010: Jun Hee Lee; Andrei V Budanov; Eek Joong Park; Ryan Birse; Teddy E Kim; Guy A Perkins; Karen Ocorr; Mark H Ellisman; Rolf Bodmer; Ethan Bier; Michael Karin
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.
Science (New York, N.Y.) 2010;327(5970):1223-8.
2010: Wataru Shibata; Shigeo Takaishi; SureshKumar Muthupalani; D Mark Pritchard; Mark T Whary; Arlin Rogers; James G Fox; Kelly S Betz; Klaus H Kaestner; Michael Karin; Timothy C Wang
Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia.
Gastroenterology 2010;138(3):1022-34.e1-10.
2010: Sergei I Grivennikov; Michael Karin
Inflammation and oncogenesis: a vicious connection.
Current opinion in genetics & development 2010;20(1):65-71.
2010: Sergei I Grivennikov; Michael Karin
Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer.
Cytokine & growth factor reviews 2010;21(1):11-9.
2010: Eek Joong Park; Jun Hee Lee; Guann-Yi Yu; Guobin He; Syed Raza Ali; Ryan G Holzer; Christoph H Osterreicher; Hiroyuki Takahashi; Michael Karin
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression.
Cell 2010;140(2):197-208.
2010: Hiroyuki Takahashi; Hisanobu Ogata; Reiko Nishigaki; David H Broide; Michael Karin
Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation.
Cancer cell 2010;17(1):89-97.
2010: Gennaro Napolitano; Michael Karin
Sphingolipids: the oil on the TRAFire that promotes inflammation.
Science signaling 2010;3(141):pe34.
2010: Ping-Hui Tseng; Atsushi Matsuzawa; Weizhou Zhang; Takashi Mino; Dario A A Vignali; Michael Karin
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.
Nature immunology 2010;11(1):70-5.
2009: Monica Guma; Lisa Ronacher; Ru Liu-Bryan; Shinji Takai; Michael Karin; Maripat Corr
Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation.
Arthritis and rheumatism 2009;60(12):3642-50.
2009: Shin Maeda; Yohko Hikiba; Kei Sakamoto; Hayato Nakagawa; Yoshihiro Hirata; Yoku Hayakawa; Ayako Yanai; Keiji Ogura; Michael Karin; Masao Omata
Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression.
Hepatology (Baltimore, Md.) 2009;50(6):1851-60.
2009: Thomas Enzler; Arnon P Kater; Weizhou Zhang; George F Widhopf; Han-Yu Chuang; Jason Lee; Esther Avery; Carlo M Croce; Michael Karin; Thomas J Kipps
Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression.
Blood 2009;114(20):4469-76.
2009: Michael Karin
NF-kappaB as a critical link between inflammation and cancer.
Cold Spring Harbor perspectives in biology 2009;1(5):a000141.
2009: Johannes Haybaeck; Nicolas Zeller; Monika Julia Wolf; Achim Weber; Ulrich Wagner; Michael Odo Kurrer; Juliane Bremer; Giandomenica Iezzi; Rolf Graf; Pierre-Alain Clavien; Robert Thimme; Hubert Blum; Sergei A Nedospasov; Kurt Zatloukal; Muhammad Ramzan; Sandra Ciesek; Thomas Pietschmann; Patrice N Marche; Michael Karin; Manfred Kopf; Jeffrey L Browning; Adriano Aguzzi; Mathias Heikenwalder
A lymphotoxin-driven pathway to hepatocellular carcinoma.
Cancer cell 2009;16(4):295-308.
2009: Thomas Enzler; Xing Chang; Valeria Facchinetti; Gerry Melino; Michael Karin; Bing Su; Ewen Gallagher
MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3831-8.
2009: Petr Hruz; Annelies S Zinkernagel; Gabriela Jenikova; Gregory J Botwin; Jean-Pierre Hugot; Michael Karin; Victor Nizet; Lars Eckmann
NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12873-8.
2009: Monica Guma; Jordi Rius; Karen X Duong-Polk; Gabriel G Haddad; James D Lindsey; Michael Karin
Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(21):8760-5.
2009: Katherine S Koch; Shin Maeda; Guobin He; Michael Karin; Hyam L Leffert
Targeted deletion of hepatocyte Ikkbeta confers growth advantages.
Biochemical and biophysical research communications 2009;380(2):349-54.
2009: Michael Karin; Ewen Gallagher
TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes.
Immunological reviews 2009;228(1):225-40.
2009: Wen-Ming Chu; Xing Gong; Zhi-Wei Li; Kenji Takabayashi; Hong-Hai Ouyang; Yi Chen; David J Chen; Gloria C Li; Michael Karin; Eyal Raz
Retraction: DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA.
Cell 2009;136(3):565.
2009: Sergei Grivennikov; Eliad Karin; Janos Terzic; Daniel Mucida; Guann-Yi Yu; Sivakumar Vallabhapurapu; Jürgen Scheller; Stefan Rose-John; Hilde Cheroutre; Lars Eckmann; Michael Karin
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.
Cancer cell 2009;15(2):103-13.
2009: Anjuli M Timmer; John C Timmer; Morgan A Pence; Li-Chung Hsu; Mariam Ghochani; Terrence G Frey; Michael Karin; Guy S Salvesen; Victor Nizet
Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis.
The Journal of biological chemistry 2009;284(2):862-71.
2009: Merav Darash-Yahana; John W Gillespie; Stephen M Hewitt; Yun-Yun K Chen; Shin Maeda; Ilan Stein; Satya P Singh; Roble B Bedolla; Amnon Peled; Dean A Troyer; Eli Pikarsky; Michael Karin; Joshua M Farber
The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers.
PloS one 2009;4(8):e6695.
2009: Sivakumar Vallabhapurapu; Michael Karin
Regulation and function of NF-kappaB transcription factors in the immune system.
Annual review of immunology 2009;27():693-733.
2009: Sunhwa Kim; Hiroyuki Takahashi; Wan-Wan Lin; Pascal Descargues; Sergei Grivennikov; Youngjun Kim; Jun-Li Luo; Michael Karin
Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis.
Nature 2009;457(7225):102-6.
2009: Véronique Baud; Michael Karin
Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls.
Nature reviews. Drug discovery 2009;8(1):33-40.
2009: Barbara Marinari; Costanza Ballaro; Maranke I Koster; Maria Laura Giustizieri; Francesca Moretti; Francesca Crosti; Marina Papoutsaki; Michael Karin; Stefano Alema; Sergio Chimenti; Dennis R Roop; Antonio Costanzo
IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias.
The Journal of investigative dermatology 2009;129(1):60-9.
2008: Haopeng Wang; Atsushi Matsuzawa; Scott A Brown; JingRan Zhou; Cliff S Guy; Ping-Hui Tseng; Karen Forbes; Thomas P Nicholson; Paul Sheppard; Hans Häcker; Michael Karin; Dario A A Vignali
Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(51):20197-202.
2008: Sivakumar Vallabhapurapu; Atsushi Matsuzawa; Weizhou Zhang; Ping-Hui Tseng; Jonathan J Keats; Haopeng Wang; Dario A A Vignali; P Leif Bergsagel; Michael Karin
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.
Nature immunology 2008;9(12):1364-70.
2008: Barbara Marinari; Fabiola Moretti; Elisabetta Botti; Maria Laura Giustizieri; Pascal Descargues; Alessandro Giunta; Carmine Stolfi; Costanza Ballaro; Marina Papoutsaki; Stefano Alemà; Giovanni Monteleone; Sergio Chimenti; Michael Karin; Antonio Costanzo
The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(44):17091-6.
2008: Ik-Hyun Cho; Jinpyo Hong; Eun Cheng Suh; Jae Hwan Kim; Hyunkyoung Lee; Jong Eun Lee; Sarpong Mr.Samuel; Chong-Hyun Kim; Dong Woon Kim; Eun-Kyeong Jo; Kyung Eun Lee; Michael Karin; Sung Joong Lee
Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death.
Brain : a journal of neurology 2008;131(Pt 11):3019-33.
2008: John L Stebbins; Surya K De; thomas machleidt; Barbara Becattini; Jesus Vazquez; Christian Kuntzen; Li-Hsing Chen; Jason F Cellitti; Megan Riel-Mehan; Aras Emdadi; Giovanni Solinas; Michael Karin; Maurizio Pellecchia
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(43):16809-13.
2008: Pascal Descargues; Alok K Sil; Michael Karin
IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer.
The EMBO journal 2008;27(20):2639-47.
2008: B Sun; Michael Karin
NF-kappaB signaling, liver disease and hepatoprotective agents.
Oncogene 2008;27(48):6228-44.
2008: Xiaoqing Zhang; Guo Zhang; Hai Zhang; Michael Karin; Hua Bai; Dongsheng Cai
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity.
Cell 2008;135(1):61-73.
2008: Yanjun Hou; Fu Li; Michael Karin; Michael C Ostrowski
Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(10):2926-35.
2008: Hayato Nakagawa; Shin Maeda; Yohko Hikiba; Tomoya Ohmae; Wataru Shibata; Ayako Yanai; Kei Sakamoto; Keiji Ogura; Takuya Noguchi; Michael Karin; Hidenori Ichijo; Masao Omata
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
Gastroenterology 2008;135(4):1311-21.
2008: Lars Eckmann; Tim Nebelsiek; Alexander A Fingerle; Sara M Dann; Jörg Mages; Roland Lang; Sylvie Robine; Martin F Kagnoff; Roland M Schmid; Michael Karin; Melek C Arkan; Florian R Greten
Opposing functions of IKKbeta during acute and chronic intestinal inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):15058-63.
2008: Toshiharu Sakurai; Guobin He; Atsushi Matsuzawa; Guann-Yi Yu; Shin Maeda; Hardiman Gary; Michael Karin
Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis.
Cancer cell 2008;14(2):156-65.
2008: Andrei V Budanov; Michael Karin
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
Cell 2008;134(3):451-60.
2008: Atsushi Matsuzawa; Ping-Hui Tseng; Sivakumar Vallabhapurapu; Jun-Li Luo; Weizhou Zhang; Haopeng Wang; Dario A A Vignali; Ewen Gallagher; Michael Karin
Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.
Science (New York, N.Y.) 2008;321(5889):663-8.
2008: Francesca Bernassola; Michael Karin; Aaron Ciechanover; Gerry Melino
The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
Cancer cell 2008;14(1):10-21.
2008: Wataru Shibata; Shin Maeda; Yohko Hikiba; Ayako Yanai; Kei Sakamoto; Hayato Nakagawa; Keiji Ogura; Michael Karin; Masao Omata
c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice.
Cancer research 2008;68(13):5031-9.
2008: Carol Ho Yan Fong; Magali Bebien; Arnaud Didierlaurent; Ruth Nebauer; Tracy Hussell; David Broide; Michael Karin; Toby Lawrence
An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation.
The Journal of experimental medicine 2008;205(6):1269-76.
2008: Jordi Rius; Monica Guma; Christian Schachtrup; Katerina Akassoglou; Annelies S Zinkernagel; Victor Nizet; Randall S Johnson; Gabriel G Haddad; Michael Karin
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha.
Nature 2008;453(7196):807-11.
2008: Li-Chung Hsu; Syed R Ali; Shauna McGillivray; Ping-Hui Tseng; Sanjeev Mariathasan; Eric W Humke; Lars Eckmann; Jonathan J Powell; Victor Nizet; Xiaodong Huang; Michael Karin
A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(22):7803-8.
2008: C Julius; Mathias Heikenwalder; Petra Schwarz; A Marcel; Michael Karin; Marco Prinz; M Pasparakis; Adriano Aguzzi
Prion propagation in mice lacking central nervous system NF-kappaB signalling.
The Journal of general virology 2008;89(Pt 6):1545-50.
2008: Michael Karin
The IkappaB kinase - a bridge between inflammation and cancer.
Cell research 2008;18(3):334-42.
2008: Willscott E (Scott) Naugler; Michael Karin
The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer.
Trends in molecular medicine 2008;14(3):109-19.
2008: Pascal Descargues; Alok K Sil; Yuji Sano; Olexander Korchynskyi; Gangwen Han; Philip Owens; Xiao-Jing Wang; Michael Karin
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2487-92.
2008: Peter Herrlich; Michael Karin; Carsten Weiss
Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response.
Molecular cell 2008;29(3):279-90.
2008: Willscott E (Scott) Naugler; Michael Karin
NF-kappaB and cancer-identifying targets and mechanisms.
Current opinion in genetics & development 2008;18(1):19-26.
2008: Ulrich Meinzer; Sophie Esmiol-Welterlin; Frederick Barreau; Dominique Berrebi; Monique Dussaillant; Stephane Bonacorsi; Fabrice Chareyre; Michiko Niwa-Kawakita; Corinne Alberti; Ghislaine Sterkers; Claude Villard; Thecla Lesuffleur; Michel Peuchmaur; Michael Karin; Lars Eckmann; Marco Giovannini; Vincent Ollendorff; Hans Wolf-Watz; Jean-Pierre Hugot
Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice.
PloS one 2008;3(7):e2769.
2008: Sergei Grivennikov; Michael Karin
Autocrine IL-6 signaling: a key event in tumorigenesis?
Cancer cell 2008;13(1):7-9.
2007: Vladislav Temkin; Michael Karin
From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey.
Immunological reviews 2007;220():8-21.
2007: Giovanni Solinas; Cristian Vilcu; Jaap G Neels; Gautam K Bandyopadhyay; Jun-Li Luo; Willscott E (Scott) Naugler; Sergei Grivennikov; Anthony Wynshaw-Boris; Miriam Scadeng; Jerrold M Olefsky; Michael Karin
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity.
Cell metabolism 2007;6(5):386-97.
2007: Michael Karin
Rsk Tolls the bell for endocytosis in DCs.
Nature immunology 2007;8(11):1197-9.
2007: Devin Drew; Eriko Shimada; Kim Huynh; Simon Bergqvist; Rashmi Talwar; Michael Karin; riya ghosh
Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma.
Biochemistry 2007;46(43):12482-90.
2007: Yixue Cao; Jun-Li Luo; Michael Karin
IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(40):15852-7.
2007: Florian R Greten; Melek C Arkan; Julia Bollrath; Li-Chung Hsu; Jason Goode; Cornelius Miething; Serkan I Göktuna; Michael Neuenhahn; Joshua Fierer; Stephan Paxian; Nico van Rooijen; Yajun Xu; Timothy O'Cain; Bruce B Jaffee; Dirk H Busch; Justus Duyster; Roland M Schmid; Lars Eckmann; Michael Karin
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.
Cell 2007;130(5):918-31.
2007: Carter Van Waes; Ming Yu; Liesl Nottingham; Michael Karin
Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(17):4956-9.
2007: Willscott E (Scott) Naugler; Toshiharu Sakurai; Sunhwa Kim; Shin Maeda; KYOUNGHYUN Kim; Ahmed M Elsharkawy; Michael Karin
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production.
Science (New York, N.Y.) 2007;317(5834):121-4.
2007: Wan-Wan Lin; Michael Karin
A cytokine-mediated link between innate immunity, inflammation, and cancer.
The Journal of clinical investigation 2007;117(5):1175-83.
2007: Lee-Wei Chen; Pei-Hsuan Chen; Wei-Jung Chang; Jyh-Seng Wang; Michael Karin; Ching-Mei Hsu
IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation.
Critical care medicine 2007;35(5):1332-40.
2007: David M Mills; Giuseppina Bonizzi; Michael Karin; Robert C Rickert
Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6359-64.
2007: Jun-Li Luo; Wei Tan; Jill M Ricono; Olexandr Korchynskyi; Ming Zhang; Steven L Gonias; David A Cheresh; Michael Karin
Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.
Nature 2007;446(7136):690-4.
2007: Swarnali Acharyya; S Armando Villalta; Nadine Bakkar; Tepmanas Bupha-Intr; Paul Janssen; Micheal Carathers; Zhi-Wei Li; Amer A Beg; Sankar Ghosh; Zarife Sahenk; Michael Weinstein; Katherine L Gardner; Jill A Rafael-Fortney; Michael Karin; James G Tidball; Albert S Baldwin; Denis C Guttridge
Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.
The Journal of clinical investigation 2007;117(4):889-901.
2007: Colby Zaph; Amy E Troy; Betsy C Taylor; Lisa D Berman-Booty; Katherine J Guild; Yurong Du; Evan A Yost; Achim D Gruber; Michael May; Florian R Greten; Lars Eckmann; Michael Karin; David Artis
Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis.
Nature 2007;446(7135):552-6.
2007: Andrew J Lickteig; Angela L Slitt; Melek C Arkan; Michael Karin; Nathan J Cherrington
Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(3):402-9.
2007: Maranke I Koster; Daisy Dai; Barbara Marinari; Yuji Sano; Antonio Costanzo; Michael Karin; Dennis R Roop
p63 induces key target genes required for epidermal morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3255-60.
2007: R Lin; S Maeda; C Liu; Michael Karin; Thomas S Edgington
A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas.
Oncogene 2007;26(6):851-8.
2007: Sunshin Kim; Isabelle Millet; Hun Sik Kim; Ja Young Kim; Myoung Sook Han; Moon-Kyu Lee; Kwang-Won Kim; Robert S Sherwin; Michael Karin; Myung-Shik Lee
NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):1913-8.
2007: Tomoyuki Endo; Mitsufumi Nishio; Thomas Enzler; Howard B Cottam; Tetsuya Fukuda; Danelle F James; Michael Karin; Thomas Kipps
BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway.
Blood 2007;109(2):703-10.
2007: Maria Grazia Ruocco; Michael Karin
Control of osteoclast activity and bone loss by IKK subunits: new targets for therapy.
Advances in experimental medicine and biology 2007;602():125-34.
2007: Ewen Gallagher; Thomas Enzler; Atsushi Matsuzawa; Amy Anzelon-Mills; Otero Dennis; Ryan Holzer; edith janssen; Min Gao; Michael Karin
Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production.
Nature immunology 2007;8(1):57-63.
2006: Fei Chen; Yongju Lu; Vincent Castranova; Zhiwei Li; Michael Karin
Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells.
The Journal of biological chemistry 2006;281(48):37142-9.
2006: Michael Karin
Role for IKK2 in muscle: waste not, want not.
The Journal of clinical investigation 2006;116(11):2866-8.
2006: Ziyue Lu; Lena Serghides; Samir N Patel; Norbert Degousee; Barry B Rubin; Gowdahalli Krishnegowda; D Channe Gowda; Michael Karin; Kevin Kain
Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6344-52.
2006: Giovanni Solinas; Willscott E (Scott) Naugler; Francesco Galimi; Myung-Shik Lee; Michael Karin
Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16454-9.
2006: Hans Häcker; Michael Karin
Regulation and function of IKK and IKK-related kinases.
Science's STKE : signal transduction knowledge environment 2006;2006(357):re13.
2006: Thomas Enzler; Giuseppina Bonizzi; Gregg J Silverman; Otero Dennis; George F Widhopf; Amy Anzelon-Mills; Robert C Rickert; Michael Karin
Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease.
Immunity 2006;25(3):403-15.
2006: tord labuda; Jan Pravsgaard Christensen; Susanne Rasmussen; Barbara Bonnesen; Michael Karin; Allan Randrup Thomsen; Niels Odum
MEK kinase 1 is a negative regulator of virus-specific CD8(+) T cells.
European journal of immunology 2006;36(8):2076-84.
2006: Donalyn Scheuner; Rupali Patel; Feng Wang; Kuei Lee; Kotlo Kumar; Jun Wu; Anders Nilsson; Michael Karin; Randal J Kaufman
Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis.
The Journal of biological chemistry 2006;281(30):21458-68.
2006: Sungwon Chae; Lars Eckmann; Yukiko Miyamoto; Charalabos Pothoulakis; Michael Karin; Martin F Kagnoff
Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1214-20.
2006: Gürol Tuncman; Jiro Hirosumi; Giovanni Solinas; Lufen Chang; Michael Karin; Gökhan S Hotamisligil
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10741-6.
2006: Toshiharu Sakurai; Shin Maeda; Lufen Chang; Michael Karin
Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10544-51.
2006: Etienne Meylan; Jürg Tschopp; Michael Karin
Intracellular pattern recognition receptors in the host response.
Nature 2006;442(7098):39-44.
2006: Michael Karin
NF-kappaB and cancer: mechanisms and targets.
Molecular carcinogenesis 2006;45(6):355-61.
2006: Michael Karin
Nuclear factor-kappaB in cancer development and progression.
Nature 2006;441(7092):431-6.
2006: Venuprasad Poojary; Chris Elly; Min Gao; Shahram Salek-Ardakani; Yohsuke Harada; Jun-Li Luo; Chun Yang; Michael Croft; Kazushi Inoue; Michael Karin; Yun-Cai Liu
Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation.
The Journal of clinical investigation 2006;116(4):1117-26.
2006: Annabel Guichard; Jin Mo Park; Beatriz Cruz-Moreno; Michael Karin; Ethan Bier
Anthrax lethal factor and edema factor act on conserved targets in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3244-9.
2006: Michael Karin; Toby Lawrence; Victor Nizet
Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer.
Cell 2006;124(4):823-35.
2006: Tina Mahieu; Jin Mo Park; Hilde Revets; Bastian Pasche; Andreas Lengeling; Jeroen Staelens; Andy Wullaert; Ineke Vanlaere; Tino Hochepied; Frans van Roy; Michael Karin; Claude Libert
The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2292-7.
2006: Lufen Chang; Hideaki Kamata; Giovanni Solinas; Jun-Li Luo; Shin Maeda; Venuprasad Poojary; Yun-Cai Liu; Michael Karin
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.
Cell 2006;124(3):601-13.
2006: Ewen Gallagher; Min Gao; Yun-Cai Liu; Michael Karin
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1717-22.
2006: Hans Häcker; Vanessa Redecke; Blagoy Blagoev; Irina Kratchmarova; Li-Chung Hsu; Gang G Wang; Mark P Kamps; Eyal Raz; Hermann Wagner; Georg Häcker; Matthias Mann; Michael Karin
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6.
Nature 2006;439(7073):204-7.
2006: Michael Karin
Tracking the road from inflammation to cancer: the critical role of IkappaB kinase (IKK).
Harvey lectures 2006;102():133-51.
2005: Paola Briata; Sonia Vanina Forcales; Marco Ponassi; Giorgio Corte; Ching-Yi Chen; Michael Karin; Pier Lorenzo Puri; Roberto Gherzi
p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts.
Molecular cell 2005;20(6):891-903.
2005: David H Broide; Toby Lawrence; Taylor Doherty; Jae Youn Cho; Marina Miller; Kirsti McElwain; Shauna McElwain; Michael Karin
Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(49):17723-8.
2005: Yun-Cai Liu; Josef M Penninger; Michael Karin
Immunity by ubiquitylation: a reversible process of modification.
Nature reviews. Immunology 2005;5(12):941-52.
2005: Jun-Li Luo; Hideaki Kamata; Michael Karin
The anti-death machinery in IKK/NF-kappaB signaling.
Journal of clinical immunology 2005;25(6):541-50.
2005: Maria Grazia Ruocco; Michael Karin
IKK{beta} as a target for treatment of inflammation induced bone loss.
Annals of the rheumatic diseases 2005;64 Suppl 4():iv81-5.
2005: Jun-Li Luo; Hideaki Kamata; Michael Karin
IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy.
The Journal of clinical investigation 2005;115(10):2625-32.
2005: Michael Karin; Florian R Greten
NF-kappaB: linking inflammation and immunity to cancer development and progression.
Nature reviews. Immunology 2005;5(10):749-59.
2005: Min Gao; Michael Karin
Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli.
Molecular cell 2005;19(5):581-93.
2005: Jin Mo Park; Florian R Greten; Athena Wong; Randal J Westrick; J Simon C Arthur; Kinya Otsu; Alexander Hoffmann; Marc Montminy; Michael Karin
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators.
Immunity 2005;23(3):319-29.
2005: Shin Maeda; Hideaki Kamata; Jun-Li Luo; Hyam Leffert; Michael Karin
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis.
Cell 2005;121(7):977-90.
2005: Lars Eckmann; Michael Karin
NOD2 and Crohn's disease: loss or gain of function?
Immunity 2005;22(6):661-7.
2005: Ping Zhang; Justin Chan; Ana-Maria Dragoi; Xing Gong; Stanimir Ivanov; Zhi-Wei Li; Tsung-Hsien Chuang; Tsheng Chuang; Cynthia Tuthill; Yinsheng Wan; Michael Karin; Wen-Ming Chu
Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway.
EMBO reports 2005;6(6):531-7.
2005: Maria Grazia Ruocco; Shin Maeda; Jin Mo Park; Toby Lawrence; Li-Chung Hsu; Yixue Cao; Georg Schett; Erwin F Wagner; Michael Karin
I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.
The Journal of experimental medicine 2005;201(10):1677-87.
2005: Toby Lawrence; Magali Bebien; George Y Liu; Victor Nizet; Michael Karin
IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation.
Nature 2005;434(7037):1138-43.
2005: Michael Karin; Ewen Gallagher
From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance.
IUBMB life 2005;57(4-5):283-95.
2005: Hideaki Kamata; Shi-Ichi Honda; Shin Maeda; Lufen Chang; Hajime Hirata; Michael Karin
Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases.
Cell 2005;120(5):649-61.
2005: Shin Maeda; Li-Chung Hsu; Hongjun Liu; Laurie A Bankston; Mitsutoshi Iimura; Martin F Kagnoff; Lars Eckmann; Michael Karin
Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing.
Science (New York, N.Y.) 2005;307(5710):734-8.
2005: Melek C Arkan; Andrea L Hevener; Florian R Greten; Shin Maeda; Zhi-Wei Li; Jeffrey M Long; Anthony Wynshaw-Boris; Giuseppe Poli; Jerrold M Olefsky; Michael Karin
IKK-beta links inflammation to obesity-induced insulin resistance.
Nature medicine 2005;11(2):191-8.
2005: Michael Karin
Inflammation-activated protein kinases as targets for drug development.
Proceedings of the American Thoracic Society 2005;2(4):386-90; discussion 394-5.
2005: Michael Karin
Inflammation and cancer: the long reach of Ras.
Nature medicine 2005;11(1):20-1.
2004: Annabel F Valledor; Li-Chung Hsu; Sumito Ogawa; Dominique Sawka-Verhelle; Michael Karin; Christopher K Glass
Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(51):17813-8.
2004: Jin Mo Park; Vincent H Ng; Shin Maeda; Richard F Rest; Michael Karin
Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists.
The Journal of experimental medicine 2004;200(12):1647-55.
2004: Danielle L Drayton; Giuseppina Bonizzi; Xiaoyan Ying; Shan Liao; Michael Karin; Nancy H Ruddle
I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6161-8.
2004: Michael Karin
Mitogen activated protein kinases as targets for development of novel anti-inflammatory drugs.
Annals of the rheumatic diseases 2004;63 Suppl 2():ii62-ii64.
2004: Giuseppina Bonizzi; Magali Bebien; Otero Dennis; Kirsten E Johnson-Vroom; Yixue Cao; Dung M Vu; anil jegga; Bruce Aronow; riya ghosh; Robert C Rickert; Michael Karin
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers.
The EMBO journal 2004;23(21):4202-10.
2004: Min Gao; tord labuda; Ying Xia; Ewen Gallagher; Deyu Fang; Yun-Cai Liu; Michael Karin
Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch.
Science (New York, N.Y.) 2004;306(5694):271-5.
2004: Kanaga Sabapathy; Konrad Hochedlinger; Shin Yuen Nam; anton bauer; Michael Karin; Erwin F Wagner
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation.
Molecular cell 2004;15(5):713-25.
2004: Jun-Li Luo; Shin Maeda; Li-Chung Hsu; Hideo Yagita; Michael Karin
Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression.
Cancer cell 2004;6(3):297-305.
2004: Florian R Greten; Lars Eckmann; Tim F Greten; Jin Mo Park; Zhi-Wei Li; Laurence J Egan; Martin F Kagnoff; Michael Karin
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
Cell 2004;118(3):285-96.
2004: Soojin Lee; Jinpyo Hong; Se-Young Choi; Seog Bae Oh; Kyungpyo Park; Joong Soo Kim; Michael Karin; Sung Joong Lee
CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-kappaB activation.
Journal of neuroimmunology 2004;153(1-2):50-63.
2004: Zhi-Wei Li; Robert C Rickert; Michael Karin
Genetic dissection of antigen receptor induced-NF-kappaB activation.
Molecular immunology 2004;41(6-7):701-14.
2004: Han-Ming Shen; Yong Lin; Swati Choksi; Jamie Tran; Tian Jin; Lufen Chang; Michael Karin; Jianke Zhang; Zheng-gang Liu
Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death.
Molecular and cellular biology 2004;24(13):5914-22.
2004: Roberto Gherzi; Kyung-Yeol Lee; Paola Briata; Daniel Wegmüller; Christoph Moroni; Michael Karin; Ching-Yi Chen
A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.
Molecular cell 2004;14(5):571-83.
2004: Alema Galijatovic; Deirdre Beaton; Nghia Nguyen; Shujuan Chen; Jessica A Bonzo; Randall Johnson; Shin Maeda; Michael Karin; F Peter Guengerich; Robert H Tukey
The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice.
The Journal of biological chemistry 2004;279(23):23969-76.
2004: Giuseppina Bonizzi; Michael Karin
The two NF-kappaB activation pathways and their role in innate and adaptive immunity.
Trends in immunology 2004;25(6):280-8.
2004: Alok K Sil; Shin Maeda; Yuji Sano; Dennis R Roop; Michael Karin
IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis.
Nature 2004;428(6983):660-4.
2004: Florian R Greten; Michael Karin
The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer.
Cancer letters 2004;206(2):193-9.
2004: Ruthie E Amir; Hans Haecker; Michael Karin; Aaron Ciechanover
Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase.
Oncogene 2004;23(14):2540-7.
2004: Li-Chung Hsu; Jin Mo Park; Kezhong Zhang; Jun-Li Luo; Shin Maeda; Randal J Kaufman; Lars Eckmann; Donald G Guiney; Michael Karin
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.
Nature 2004;428(6980):341-5.
2004: Jin Mo Park; Helen Brady; Maria Grazia Ruocco; Huaiyu Sun; DeeAnn Williams; Susan J Lee; Tomohisa Kato; Normand Richards; Kyle Chan; Frank Mercurio; Michael Karin; Steven A Wasserman
Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila.
Genes & development 2004;18(5):584-94.
2004: Laurence J Egan; Lars Eckmann; Florian R Greten; Sungwon Chae; Zhi-Wei Li; Gennett M Myhre; Sylvie Robine; Michael Karin; Martin F Kagnoff
IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2452-7.
2004: Ying Xia; Michael Karin
The control of cell motility and epithelial morphogenesis by Jun kinases.
Trends in cell biology 2004;14(2):94-101.
2004: Atsushi Ohazama; Yinling Hu; Ruth Schmidt-Ullrich; Yixue Cao; Claus Scheidereit; Michael Karin; Paul T Sharpe
A dual role for Ikk alpha in tooth development.
Developmental cell 2004;6(2):219-27.
2004: Michael Karin; Yumi Yamamoto; Q May Wang
The IKK NF-kappa B system: a treasure trove for drug development.
Nature reviews. Drug discovery 2004;3(1):17-26.
2003: Fei Chen; Vincent Castranova; Zhiwei Li; Michael Karin; Xianglin Shi
Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic.
Cancer research 2003;63(22):7689-93.
2003: Shin Maeda; Lufen Chang; Zhi-Wei Li; Jun-Li Luo; Hyam Leffert; Michael Karin
IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha.
Immunity 2003;19(5):725-37.
2003: Fumitaka Fujita; Yuko Taniguchi; Takashi Kato; Yasuko Narita; Akiko Furuya; Tatsuhiro Ogawa; Hiroaki Sakurai; Takashi Joh; Makoto Itoh; Mireille Delhase; Michael Karin; Makoto Nakanishi
Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.
Molecular and cellular biology 2003;23(21):7780-93.
2003: Tomohisa Kato; Mireille Delhase; Alexander Hoffmann; Michael Karin
CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response.
Molecular cell 2003;12(4):829-39.
2003: Lin Zhang; Wei Wang; Yasuhito Hayashi; James V Jester; David E Birk; Min Gao; Chia-Yang Liu; Winston W-Y Kao; Michael Karin; Ying Xia
A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure.
The EMBO journal 2003;22(17):4443-54.
2003: Makio Hayakawa; Hiroshi Miyashita; Isao Sakamoto; Masatoshi Kitagawa; Hirofumi Tanaka; Hideyo Yasuda; Michael Karin; Kiyomi Kikugawa
Evidence that reactive oxygen species do not mediate NF-kappaB activation.
The EMBO journal 2003;22(13):3356-66.
2003: Shujuan Chen; Nghia Nguyen; Kumiko Tamura; Michael Karin; Robert H Tukey
The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis.
The Journal of biological chemistry 2003;278(21):19526-33.
2003: Zhi-Wei Li; Sidne A Omori; tord labuda; Michael Karin; Robert C Rickert
IKK beta is required for peripheral B cell survival and proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(9):4630-7.
2003: Jonathan Shillingford; Keiko Miyoshi; Gertraud W Robinson; Brian Bierie; Yixue Cao; Michael Karin; Lothar Hennighausen
Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003;51(5):555-65.
2003: Lee-Wei Chen; Laurence J Egan; Zhi-Wei Li; Florian R Greten; Martin F Kagnoff; Michael Karin
The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion.
Nature medicine 2003;9(5):575-81.
2003: Yixue Cao; Michael Karin
NF-kappaB in mammary gland development and breast cancer.
Journal of mammary gland biology and neoplasia 2003;8(2):215-23.
2003: Lufen Chang; Ying Z Jones; Mark H Ellisman; Lawrence S B Goldstein; Michael Karin
JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins.
Developmental cell 2003;4(4):521-33.
2003: Anning Lin; Michael Karin
NF-kappaB in cancer: a marked target.
Seminars in cancer biology 2003;13(2):107-14.
2003: Shin Maeda; Michael Karin
Oncogene at last--c-Jun promotes liver cancer in mice.
Cancer cell 2003;3(2):102-4.
2003: Yolanda Bayon; Maria A Ortiz; Francisco J Lopez-Hernandez; Feng Gao; Michael Karin; Magnus Pfahl; F Javier Piedrafita
Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis.
Molecular and cellular biology 2003;23(3):1061-74.
2002: Jaekyung Shim; Michael Karin
The control of mRNA stability in response to extracellular stimuli.
Molecules and cells 2002;14(3):323-31.
2002: Jaekyung Shim; Hanjo Lim; John R Yates; Michael Karin
Nuclear export of NF90 is required for interleukin-2 mRNA stabilization.
Molecular cell 2002;10(6):1331-44.
2002: Hans Häcker; Michael Karin
Is NF-kappaB2/p100 a direct activator of programmed cell death?
Cancer cell 2002;2(6):431-3.
2002: Jiro Hirosumi; Gürol Tuncman; Lufen Chang; Cem Z Görgün; Teo Uysal; Kazuhisa Maeda; Michael Karin; Gökhan S Hotamisligil
A central role for JNK in obesity and insulin resistance.
Nature 2002;420(6913):333-6.
2002: Yoko Takanami-Ohnishi; Shinya Amano; Sadao Kimura; Sachie Asada; Atsushi Utani; Masumi Maruyama; Hiroyuki Osada; Hajime Tsunoda; Yoko Irukayama-Tomobe; Katsutoshi Goto; Michael Karin; Tatsuhiko Sudo; Yoshitoshi Kasuya
Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity.
The Journal of biological chemistry 2002;277(40):37896-903.
2002: Emmanuel Dejardin; Nathalie M Droin; Mireille Delhase; Elvira Haas; Yixue Cao; Constantin Makris; Zhi-Wei Li; Michael Karin; Carl Ware; Douglas R Green
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
Immunity 2002;17(4):525-35.
2002: Jin Mo Park; Florian R Greten; Zhi-Wei Li; Michael Karin
Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition.
Science (New York, N.Y.) 2002;297(5589):2048-51.
2002: Constantin Makris; Jaclyn L Roberts; Michael Karin
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.
Molecular and cellular biology 2002;22(18):6573-81.
2002: Li Wang; Yoon-Kwang Lee; Donnie Bundman; Yunqing Han; Sundararajah Thevananther; Chang Soo Kim; Steven S Chua; Ping Wei; Richard A Heyman; Michael Karin; David D Moore
Redundant pathways for negative feedback regulation of bile acid production.
Developmental cell 2002;2(6):721-31.
2002: Eitan Shaulian; Michael Karin
AP-1 as a regulator of cell life and death.
Nature cell biology 2002;4(5):E131-6.
2002: Kazuhiko Yoshida; Axcel Behrens; Helen Le-Niculescu; Erwin F Wagner; Takayuki Harada; Junko Imaki; Shigeaki Ohno; Michael Karin
Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection.
Investigative ophthalmology & visual science 2002;43(5):1631-5.
2002: Michael Karin; Yixue Cao; Florian R Greten; Zhi-Wei Li
NF-kappaB in cancer: from innocent bystander to major culprit.
Nature reviews. Cancer 2002;2(4):301-10.
2002: Sankar Ghosh; Michael Karin
Missing pieces in the NF-kappaB puzzle.
Cell 2002;109 Suppl():S81-96.
2002: Zuoning Han; Lufen Chang; Yuji Yamanishi; Michael Karin; Gary S Firestein
Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis.
Arthritis and rheumatism 2002;46(3):818-23.
2002: Michael Karin; Anning Lin
NF-kappaB at the crossroads of life and death.
Nature immunology 2002;3(3):221-7.
2002: Uwe Senftleben; Michael Karin
The IKK/NF-kappa B pathway.
Critical care medicine 2002;30(1 Suppl):S18-26.
2001: Yixue Cao; Giuseppina Bonizzi; Tiffany N. Seagroves; Florian R Greten; R Johnson; E V Schmidt; Michael Karin
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.
Cell 2001;107(6):763-75.
2001: C Y Chen; Roberto Gherzi; Shao-En Ong; E L Chan; Reinout Raijmakers; G J Pruijn; Georg Stoecklin; Christoph Moroni; M Mann; Michael Karin
AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.
Cell 2001;107(4):451-64.
2001: Guilin Tang; Yuzuru Minemoto; Benjamin C Dibling; NH Purcell; Z Li; Michael Karin; Anning Lin
Inhibition of JNK activation through NF-kappaB target genes.
Nature 2001;414(6861):313-7.
2001: Véronique Baud; Michael Karin
Signal transduction by tumor necrosis factor and its relatives.
Trends in cell biology 2001;11(9):372-7.
2001: Minsheng Yuan; N Konstantopoulos; Junghee Lee; Lone Hansen; Z W Li; Michael Karin; Steven E Shoelson
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta.
Science (New York, N.Y.) 2001;293(5535):1673-7.
2001: Uwe Senftleben; Yixue Cao; Gutian Xiao; Florian R Greten; G Krähn; Giuseppina Bonizzi; Yi Chen; Yinling Hu; A Fong; Shao-Cong Sun; Michael Karin
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway.
Science (New York, N.Y.) 2001;293(5534):1495-9.
2001: Jason K Kim; Yoon-Jung Kim; Jonathan J Fillmore; Yibang Chen; I Moore; J Lee; M Yuan; Z W Li; Michael Karin; Pascale Perret; Steven E Shoelson; Gerald I Shulman
Prevention of fat-induced insulin resistance by salicylate.
The Journal of clinical investigation 2001;108(3):437-46.
2001: Michael Karin; E Shaulian
AP-1: linking hydrogen peroxide and oxidative stress to the control of cell proliferation and death.
IUBMB life 2001;52(1-2):17-24.
2001: Z Han; David L Boyle; Lufen Chang; B Bennett; Michael Karin; L Yang; Anthony Manning; Gary S Firestein
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.
The Journal of clinical investigation 2001;108(1):73-81.
2001: B Jiménez; Olga V Volpert; Frank Reiher; L Chang; Alberto Muñoz; Michael Karin; Noel P Bouck
c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1.
Oncogene 2001;20(26):3443-8.
2001: Michael Karin; L Chang
AP-1--glucocorticoid receptor crosstalk taken to a higher level.
The Journal of endocrinology 2001;169(3):447-51.
2001: Anne Devin; Yong Lin; S Yamaoka; Z Li; Michael Karin
The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF.
Molecular and cellular biology 2001;21(12):3986-94.
2001: Emmanuel A Ojo-Amaize; P Kapahi; Vellalore N Kakkanaiah; T Takahashi; T Shalom-Barak; Howard B Cottam; Akinbo A Adesomoju; Emeka J Nchekwube; Olusola A Oyemade; Michael Karin; Joseph I Okogun
Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase.
Cellular immunology 2001;209(2):149-57.
2001: F Piu; A Aronheim; S Katz; Michael Karin
AP-1 repressor protein JDP-2: inhibition of UV-mediated apoptosis through p53 down-regulation.
Molecular and cellular biology 2001;21(9):3012-24.
2001: E Shaulian; Michael Karin
AP-1 in cell proliferation and survival.
Oncogene 2001;20(19):2390-400.
2001: Yinling Hu; V Baud; T Oga; K I Kim; Kazuhiko Yoshida; Michael Karin
IKKalpha controls formation of the epidermis independently of NF-kappaB.
Nature 2001;410(6829):710-4.
2001: Antonio Arnaiz-Villena; Michael Karin; N Bendikuze; Eduardo Gomez-Casado; Juan Moscoso; C Silvera; F S Oguz; A Sarper Diler; A De Pacho; Luis M Allende; J Guillen; Jorge Martinez-Laso
HLA alleles and haplotypes in the Turkish population: relatedness to Kurds, Armenians and other Mediterraneans.
Tissue antigens 2001;57(4):308-17.
2001: N Li; S Banin; H Ouyang; Gloria C Li; G Courtois; Yosef Shiloh; Michael Karin; Galit Rotman
ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks.
The Journal of biological chemistry 2001;276(12):8898-903.
2001: Uwe Senftleben; Zhi-Wei Li; V Baud; Michael Karin
IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis.
Immunity 2001;14(3):217-30.
2001: Lufen Chang; Michael Karin
Mammalian MAP kinase signalling cascades.
Nature 2001;410(6824):37-40.
2001: Kanaga Sabapathy; T Kallunki; Jean-Pierre David; ISabella Graef; Michael Karin; Erwin F Wagner
c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation.
The Journal of experimental medicine 2001;193(3):317-28.
2001: Valeria Cavalli; Francis Vilbois; Michela Corti; M J Marcote; K Tamura; Michael Karin; Steve Arkinstall; Jean Gruenberg
The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex.
Molecular cell 2001;7(2):421-32.
2001: Michael Karin; T Takahashi; pankaj kapahi; Mireille Delhase; Yi Chen; Constantin Makris; DM Rothwarf; V Baud; Gioacchino Natoli; Francesco Guido; N Li
Oxidative stress and gene expression: the AP-1 and NF-kappaB connections.
BioFactors (Oxford, England) 2001;15(2-4):87-9.
2001: Weijun Feng; Paul Webb; Phuong Nguyen; X Liu; J Li; Michael Karin; Peter J Kushner
Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway.
Molecular endocrinology (Baltimore, Md.) 2001;15(1):32-45.
2000: W Chu; X Gong; Z Li; K Takabayashi; H Ouyang; Yi Chen; A Lois; D J Chen; Gloria C Li; Michael Karin; E Raz
DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA.
Cell 2000;103(6):909-18.
2000: E Shaulian; M Schreiber; F Piu; M Beeche; E F Wagner; Michael Karin
The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest.
Cell 2000;103(6):897-907.
2000: pankaj kapahi; T Takahashi; Gioacchino Natoli; S R Adams; Yi Chen; Roger Y Tsien; Michael Karin
Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase.
The Journal of biological chemistry 2000;275(46):36062-6.
2000: Kazuhiko Yoshida; Yinling Hu; Michael Karin
IkappaB kinase alpha is essential for development of the mammalian cornea and conjunctiva.
Investigative ophthalmology & visual science 2000;41(12):3665-9.
2000: Mireille Delhase; N Li; Michael Karin
Kinase regulation in inflammatory response.
Nature 2000;406(6794):367-8.
2000: K Tamura; T Sudo; Uwe Senftleben; Agnes Dadak; R Johnson; Michael Karin
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.
Cell 2000;102(2):221-31.
2000: J López-Fernández; Daniela Palacios; Ana Isabel Castillo; RM Tolon; Ana Aranda; Michael Karin
Differentiation of lactotrope precursor GHFT cells in response to fibroblast growth factor-2.
The Journal of biological chemistry 2000;275(28):21653-60.
2000: J Spence; R R Gali; Gunnar A G Dittmar; F Sherman; Michael Karin; Daniel Finley
Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain.
Cell 2000;102(1):67-76.
2000: Constantin Makris; Virginia L Godfrey; G Krähn-Senftleben; T Takahashi; J L Roberts; T Schwarz; L Feng; Randall S Johnson; Michael Karin
Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti.
Molecular cell 2000;5(6):969-79.
2000: Zhiqun Wu; Pamela J Woodring; Kunjan S Bhakta; K Tamura; F Wen; James R Feramisco; Michael Karin; Jean Y J Wang; Pier Lorenzo Puri
p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps.
Molecular and cellular biology 2000;20(11):3951-64.
2000: C Y Chen; Roberto Gherzi; J S Andersen; Guido Gaietta; Karsten Jürchott; hans-dieter royer; M Mann; Michael Karin
Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation.
Genes & development 2000;14(10):1236-48.
2000: Ying Xia; Constantin Makris; B Su; E Li; Jianhua Yang; G R Nemerow; Michael Karin
MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5243-8.
2000: Y Tojima; A Fujimoto; M Delhase; Y Chen; S Hatakeyama; Kei-Ichi Nakayama; Y Kaneko; Yuji Nimura; Noboru Motoyama; Kyoji Ikeda; Michael Karin; Makoto Nakanishi
NAK is an IkappaB kinase-activating kinase.
Nature 2000;404(6779):778-82.
2000: Jinke Cheng; Jianhua Yang; Yan Xia; Michael Karin; Bing Su
Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation.
Molecular and cellular biology 2000;20(7):2334-42.
2000: Pier Lorenzo Puri; Zhiqun Wu; Peilin Zhang; Lauren D Wood; Kunjan S Bhakta; J Han; James R Feramisco; Michael Karin; Jean Y J Wang
Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells.
Genes & development 2000;14(5):574-84.
2000: Michael Karin; M Delhase
The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling.
Seminars in immunology 2000;12(1):85-98.
2000: Antonello Rossi; pankaj kapahi; Gioacchino Natoli; T Takahashi; Yi Chen; Michael Karin; M Gabriella Santoro
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase.
Nature 2000;403(6765):103-8.
2000: Ami Aronheim; Michael Karin
Analysis and identification of protein-protein interactions using protein recruitment systems.
Methods in enzymology 2000;328():47-59.
2000: T Sudo; Michael Karin
Assays for JNK and p38 mitogen-activated protein kinases.
Methods in enzymology 2000;322():388-92.
2000: N Li; Michael Karin
Signaling pathways leading to nuclear factor-kappa B activation.
Methods in enzymology 2000;319():273-9.
2000: Michael Karin; Yinon Ben-Neriah
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
Annual review of immunology 2000;18():621-63.
1999: W M Chu; Derek Ostertag; Zhi-Wei Li; Lufen Chang; Yi Chen; Yinling Hu; B Williams; Jacques Perrault; Michael Karin
JNK2 and IKKbeta are required for activating the innate response to viral infection.
Immunity 1999;11(6):721-31.
1999: Kanaga Sabapathy; W Jochum; Konrad Hochedlinger; L Chang; Michael Karin; Erwin F Wagner
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2.
Mechanisms of development 1999;89(1-2):115-24.
1999: Michael Karin
How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex.
Oncogene 1999;18(49):6867-74.
1999: DM Rothwarf; Michael Karin
The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus.
Science's STKE : signal transduction knowledge environment 1999;1999(5):RE1.
1999: E Shaulian; Michael Karin
Stress-induced JNK activation is independent of Gadd45 induction.
The Journal of biological chemistry 1999;274(42):29595-8.
1999: Michael Karin
The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation.
The Journal of biological chemistry 1999;274(39):27339-42.
1999: N Li; Michael Karin
Is NF-kappaB the sensor of oxidative stress?
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(10):1137-43.
1999: Ebrahim Zandi; Michael Karin
Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex.
Molecular and cellular biology 1999;19(7):4547-51.
1999: Zhi-Wei Li; W Chu; Yinling Hu; Mireille Delhase; Thomas J Deerinck; Mark H Ellisman; R Johnson; Michael Karin
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.
The Journal of experimental medicine 1999;189(11):1839-45.
1999: Jianmin Tian; Michael Karin
Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin).
The Journal of biological chemistry 1999;274(21):15173-80.
1999: V Baud; Z G Liu; B Bennett; N Suzuki; Ying Xia; Michael Karin
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.
Genes & development 1999;13(10):1297-308.
1999: Yinling Hu; V Baud; Mireille Delhase; P Zhang; Thomas J Deerinck; Mark H Ellisman; R Johnson; Michael Karin
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase.
Science (New York, N.Y.) 1999;284(5412):316-20.
1999: Mireille Delhase; M Hayakawa; Yi Chen; Michael Karin
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.
Science (New York, N.Y.) 1999;284(5412):309-13.
1999: M Schreiber; Andrea Kolbus; F Piu; Axel Szabowski; Uta Möhle-Steinlein; Jianmin Tian; Michael Karin; Peter Angel; Erwin F Wagner
Control of cell cycle progression by c-Jun is p53 dependent.
Genes & development 1999;13(5):607-19.
1999: Kanaga Sabapathy; Y Hu; T Kallunki; M Schreiber; Jean-Pierre David; W Jochum; Erwin F Wagner; Michael Karin
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.
Current biology : CB 1999;9(3):116-25.
1999: Thore Hettmann; JA DiDonato; Michael Karin; Jeffrey M Leiden
An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis.
The Journal of experimental medicine 1999;189(1):145-58.
1999: Mireille Delhase; Michael Karin
The I kappa B kinase: a master regulator of NF-kappa B, innate immunity, and epidermal differentiation.
Cold Spring Harbor symposia on quantitative biology 1999;64():491-503.
1999: Helen Le-Niculescu; E Bonfoco; Y Kasuya; Francois Claret; D R Green; Michael Karin
Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death.
Molecular and cellular biology 1999;19(1):751-63.
1998: Ying Xia; Zhiqun Wu; B Su; B Murray; Michael Karin
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.
Genes & development 1998;12(21):3369-81.
1998: N Li; Michael Karin
Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13012-7.
1998: DM Rothwarf; Ebrahim Zandi; G Natoli; Michael Karin
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.
Nature 1998;395(6699):297-300.
1998: Ebrahim Zandi; Yi Chen; Michael Karin
Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate.
Science (New York, N.Y.) 1998;281(5381):1360-3.
1998: MT Uhlik; L Good; Gutian Xiao; Edward W Harhaj; E Zandi; Michael Karin; Shao-Cong Sun
NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation.
The Journal of biological chemistry 1998;273(33):21132-6.
1998: Michael Karin; Mireille Delhase
JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9067-9.
1998: David Engelberg; A Mimran; H Martinetto; J Otto; Giora Simchen; Michael Karin; G R Fink
Multicellular stalk-like structures in Saccharomyces cerevisiae.
Journal of bacteriology 1998;180(15):3992-6.
1998: Thomas Herdegen; Francois Claret; Tuula Kallunki; Ana Martin Villalba; Christine Winter; Tony Hunter; Michael Karin
Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(14):5124-35.
1998: Michael Karin
Mitogen-activated protein kinase cascades as regulators of stress responses.
Annals of the New York Academy of Sciences 1998;851():139-46.
1998: C Y Chen; F Del Gatto-Konczak; Zhiqun Wu; Michael Karin
Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway.
Science (New York, N.Y.) 1998;280(5371):1945-9.
1998: Thierry Galli; Ahmed Zahraoui; V V Vaidyanathan; Graça Raposo; Jianmin Tian; Michael Karin; H Niemann; Daniel Louvard
A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells.
Molecular biology of the cell 1998;9(6):1437-48.
1998: G Werlen; Estela Jacinto; Ying Xia; Michael Karin
Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes.
The EMBO journal 1998;17(11):3101-11.
1998: Michael Karin
New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?
Cell 1998;93(4):487-90.
1998: Michael Karin
The NF-kappa B activation pathway: its regulation and role in inflammation and cell survival.
The cancer journal from Scientific American 1998;4 Suppl 1():S92-9.
1998: Estela Jacinto; G Werlen; Michael Karin
Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes.
Immunity 1998;8(1):31-41.
1997: Zhiqun Wu; J Wu; Estela Jacinto; Michael Karin
Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase.
Molecular and cellular biology 1997;17(12):7407-16.
1997: Audrey Minden; Michael Karin
Regulation and function of the JNK subgroup of MAP kinases.
Biochimica et biophysica acta 1997;1333(2):F85-104.
1997: Ebrahim Zandi; DM Rothwarf; M Delhase; M Hayakawa; Michael Karin
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.
Cell 1997;91(2):243-52.
1997: J A DiDonato; M Hayakawa; DM Rothwarf; Ebrahim Zandi; Michael Karin
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.
Nature 1997;388(6642):548-54.
1997: F Saatcioglu; G Lopez; Brian L West; E Zandi; Weijun Feng; H Lu; A Esmaili; James W Apriletti; Peter J Kushner; John D Baxter; Michael Karin
Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity.
Molecular and cellular biology 1997;17(8):4687-95.
1997: A Aronheim; Ebrahim Zandi; H Hennemann; S J Elledge; Michael Karin
Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.
Molecular and cellular biology 1997;17(6):3094-102.
1997: Peter J Barnes; Michael Karin
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.
The New England journal of medicine 1997;336(15):1066-71.
1997: Michael Karin; Z g Liu; Ebrahim Zandi
AP-1 function and regulation.
Current opinion in cell biology 1997;9(2):240-6.
1997: N Auphan; J A Didonato; A Helmberg; C Rosette; Michael Karin
Immunoregulatory genes and immunosuppression by glucocorticoids.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1997;19():87-95.
1996: T Kallunki; T Deng; Masahiko Hibi; Michael Karin
c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions.
Cell 1996;87(5):929-39.
1996: M Reach; R L Galindo; Parmalee C Towb; J L Allen; Michael Karin; Steven A Wasserman
A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo.
Developmental biology 1996;180(1):353-64.
1996: Z G Liu; R Baskaran; E T Lea-Chou; L D Wood; Yan Chen; Michael Karin; Jean Y J Wang
Three distinct signalling responses by murine fibroblasts to genotoxic stress.
Nature 1996;384(6606):273-6.
1996: M Cavigelli; Wilfred Wenfeng Li; A Lin; B Su; K Yoshioka; Michael Karin
The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase.
The EMBO journal 1996;15(22):6269-79.
1996: C Rosette; Michael Karin
Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors.
Science (New York, N.Y.) 1996;274(5290):1194-7.
1996: Z G Liu; H Hsu; D V Goeddel; Michael Karin
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death.
Cell 1996;87(3):565-76.
1996: Yi-Shuan Li; John Y-J Shyy; Song Li; J Lee; B Su; Michael Karin; Shu Chien
The Ras-JNK pathway is involved in shear-induced gene expression.
Molecular and cellular biology 1996;16(11):5947-54.
1996: Francois Claret; Masahiko Hibi; S Dhut; T Toda; Michael Karin
A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.
Nature 1996;383(6599):453-7.
1996: J A Didonato; F Saatcioglu; Michael Karin
Molecular mechanisms of immunosuppression and anti-inflammatory activities by glucocorticoids.
American journal of respiratory and critical care medicine 1996;154(2 Pt 2):S11-5.
1996: L R Collins; Audrey Minden; Michael Karin; Joan Heller Brown
Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac.
The Journal of biological chemistry 1996;271(29):17349-53.
1996: B Su; Michael Karin
Mitogen-activated protein kinase cascades and regulation of gene expression.
Current opinion in immunology 1996;8(3):402-11.
1996: J DiDonato; F Mercurio; C Rosette; J Wu-Li; H Suyang; S Ghosh; Michael Karin
Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation.
Molecular and cellular biology 1996;16(4):1295-304.
1996: Michael Karin
The regulation of AP-1 activity by mitogen-activated protein kinases.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1336):127-34.
1996: N L Johnson; A M Gardner; K M Diener; C A Lange-Carter; J Gleavy; Matthew B Jarpe; Audrey Minden; Michael Karin; L I Zon; Gary L Johnson
Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death.
The Journal of biological chemistry 1996;271(6):3229-37.
1996: Francois Claret; T Antakly; Michael Karin; F Saatcioglu
A shift in the ligand responsiveness of thyroid hormone receptor alpha induced by heterodimerization with retinoid X receptor alpha.
Molecular and cellular biology 1996;16(1):219-27.
1995: M Cavigelli; F Dolfi; Francois Claret; Michael Karin
Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.
The EMBO journal 1995;14(23):5957-64.
1995: C Caelles; H Hennemann; Michael Karin
M-phase-specific phosphorylation of the POU transcription factor GHF-1 by a cell cycle-regulated protein kinase inhibits DNA binding.
Molecular and cellular biology 1995;15(12):6694-701.
1995: N Auphan; J A DiDonato; C Rosette; A Helmberg; Michael Karin
Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis.
Science (New York, N.Y.) 1995;270(5234):286-90.
1995: Michael Karin
The regulation of AP-1 activity by mitogen-activated protein kinases.
The Journal of biological chemistry 1995;270(28):16483-6.
1995: Michael Karin; Tony Hunter
Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus.
Current biology : CB 1995;5(7):747-57.
1995: Audrey Minden; A Lin; Francois Claret; Arie Abo; Michael Karin
Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs.
Cell 1995;81(7):1147-57.
1995: K Yoshioka; T Deng; M Cavigelli; Michael Karin
Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):4972-6.
1995: A Lin; Audrey Minden; H Martinetto; Francois Claret; C Lange-Carter; F Mercurio; Gary L Johnson; Michael Karin
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.
Science (New York, N.Y.) 1995;268(5208):286-90.
1995: C Rosette; Michael Karin
Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B.
The Journal of cell biology 1995;128(6):1111-9.
1995: J A DiDonato; F Mercurio; Michael Karin
Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B.
Molecular and cellular biology 1995;15(3):1302-11.
1995: Michael A White; C Nicolette; Audrey Minden; A Polverino; Linda Van Aelst; Michael Karin; Michael Wigler
Multiple Ras functions can contribute to mammalian cell transformation.
Cell 1995;80(4):533-41.
1995: A Helmberg; N Auphan; C Caelles; Michael Karin
Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor.
The EMBO journal 1995;14(3):452-60.
1994: T Kallunki; B Su; I Tsigelny; H K Sluss; B Dérijard; G Moore; R Davis; Michael Karin
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.
Genes & development 1994;8(24):2996-3007.
1994: T Smeal; Masahiko Hibi; Michael Karin
Altering the specificity of signal transduction cascades: positive regulation of c-Jun transcriptional activity by protein kinase A.
The EMBO journal 1994;13(24):6006-10.
1994: Audrey Minden; A Lin; M McMahon; C Lange-Carter; B Dérijard; Roger J Davis; Gary L Johnson; Michael Karin
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK.
Science (New York, N.Y.) 1994;266(5191):1719-23.
1994: JK Westwick; C Weitzel; Audrey Minden; Michael Karin; David A Brenner
Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase.
The Journal of biological chemistry 1994;269(42):26396-401.
1994: Audrey Minden; A Lin; T Smeal; B Dérijard; M Cobb; R Davis; Michael Karin
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.
Molecular and cellular biology 1994;14(10):6683-8.
1994: F Saatcioglu; Francois Claret; Michael Karin
Negative transcriptional regulation by nuclear receptors.
Seminars in cancer biology 1994;5(5):347-59.
1994: A Aronheim; David Engelberg; N Li; N al-Alawi; J Schlessinger; Michael Karin
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.
Cell 1994;78(6):949-61.
1994: T Deng; Michael Karin
c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK.
Nature 1994;371(6493):171-5.
1994: J Arias; ARTHUR S ALBERTS; Paul K Brindle; Francois Claret; T Smeal; Michael Karin; James R Feramisco; Marc Montminy
Activation of cAMP and mitogen responsive genes relies on a common nuclear factor.
Nature 1994;370(6486):226-9.
1994: C Caelles; A Helmberg; Michael Karin
p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes.
Nature 1994;370(6486):220-3.
1994: David Engelberg; Ebrahim Zandi; Carl S Parker; Michael Karin
The yeast and mammalian Ras pathways control transcription of heat shock genes independently of heat shock transcription factor.
Molecular and cellular biology 1994;14(7):4929-37.
1994: C Inouye; P Remondelli; Michael Karin; S Elledge
Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system.
DNA and cell biology 1994;13(7):731-42.
1994: JK Westwick; Adrienne D Cox; Channing J Der; M H Cobb; Masahiko Hibi; Michael Karin; David A Brenner
Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6030-4.
1994: B Su; Estela Jacinto; Masahiko Hibi; T Kallunki; Michael Karin; Y Ben-Neriah
JNK is involved in signal integration during costimulation of T lymphocytes.
Cell 1994;77(5):727-36.
1994: C Trautwein; P van der Geer; Michael Karin; Tony Hunter; M Chojkier
Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements.
The Journal of clinical investigation 1994;93(6):2554-61.
1994: Q Zhang; J A Didonato; Michael Karin; Timothy W McKeithan
BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins.
Molecular and cellular biology 1994;14(6):3915-26.
1994: Michael Karin
Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors.
Current opinion in cell biology 1994;6(3):415-24.
1994: David Engelberg; C Klein; H Martinetto; K Struhl; Michael Karin
The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals.
Cell 1994;77(3):381-90.
1994: B Dérijard; Masahiko Hibi; I H Wu; Tamera Barrett; B Su; T Deng; Michael Karin; Roger J Davis
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.
Cell 1994;76(6):1025-37.
1993: F Saatcioglu; T Deng; Michael Karin
A novel cis element mediating ligand-independent activation by c-ErbA: implications for hormonal regulation.
Cell 1993;75(6):1095-105.
1993: L E Theill; Michael Karin
Transcriptional control of GH expression and anterior pituitary development.
Endocrine reviews 1993;14(6):670-89.
1993: Masahiko Hibi; A Lin; T Smeal; Audrey Minden; Michael Karin
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
Genes & development 1993;7(11):2135-48.
1993: Y Devary; C Rosette; J A DiDonato; Michael Karin
NF-kappa B activation by ultraviolet light not dependent on a nuclear signal.
Science (New York, N.Y.) 1993;261(5127):1442-5.
1993: C Trautwein; C Caelles; P van der Geer; Tony Hunter; Michael Karin; M Chojkier
Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain.
Nature 1993;364(6437):544-7.
1993: F Saatcioglu; Petr Bartunek; T Deng; Martin Zenke; Michael Karin
A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor).
Molecular and cellular biology 1993;13(6):3675-85.
1993: F Mercurio; J A DiDonato; C Rosette; Michael Karin
p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.
Genes & development 1993;7(4):705-18.
1993: ARTHUR S ALBERTS; T Deng; A Lin; Judy L Meinkoth; Axel H Schönthal; Marc C Mumby; Michael Karin; James R Feramisco
Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements.
Molecular and cellular biology 1993;13(4):2104-12.
1993: D Lew; H Brady; K Klausing; K Yaginuma; L E Theill; C Stauber; Michael Karin; Pamela L Mellon
GHF-1-promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice.
Genes & development 1993;7(4):683-93.
1993: T Deng; Michael Karin
JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers.
Genes & development 1993;7(3):479-90.
1993: P Skroch; C Buchman; Michael Karin
Regulation of human and yeast metallothionein gene transcription by heavy metal ions.
Progress in clinical and biological research 1993;380():113-28.
1993: M Hattori; A Tugores; J K Westwick; L Veloz; Hyam L Leffert; Michael Karin; David A Brenner
Activation of activating protein 1 during hepatic acute phase response.
The American journal of physiology 1993;264(1 Pt 1):G95-103.
1993: T J Ekström; W M Klump; D Getman; Michael Karin; Palmer Taylor
Promoter elements and transcriptional regulation of the acetylcholinesterase gene.
DNA and cell biology 1993;12(1):63-72.
1993: A Lin; T Smeal; B Binetruy; T Deng; J C Chambard; Michael Karin
Control of AP-1 activity by signal transduction cascades.
Advances in second messenger and phosphoprotein research 1993;28():255-60.
1993: Michael Karin; H F Yang-Yen; J C Chambard; T Deng; F Saatcioglu
Various modes of gene regulation by nuclear receptors for steroid and thyroid hormones.
European journal of clinical pharmacology 1993;45 Suppl 1():S9-15; discussion S43-4.
1992: Y Devary; Roberta Anne Gottlieb; T Smeal; Michael Karin
The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases.
Cell 1992;71(7):1081-91.
1992: Michael Karin; T Smeal
Control of transcription factors by signal transduction pathways: the beginning of the end.
Trends in biochemical sciences 1992;17(10):418-22.
1992: JoAnn Trejo; J C Chambard; Michael Karin; Joan Heller Brown
Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation.
Molecular and cellular biology 1992;12(10):4742-50.
1992: T Deng; Michael Karin
Construction and expression of a monomeric c-Jun protein that binds and activates transcription of AP-1-responsive genes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8572-6.
1992: A Lin; Jeffrey A Frost; T Deng; T Smeal; N al-Alawi; U Kikkawa; Tony Hunter; David A Brenner; Michael Karin
Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity.
Cell 1992;70(5):777-89.
1992: F Mercurio; J Didonato; C Rosette; Michael Karin
Molecular cloning and characterization of a novel Rel/NF-kappa B family member displaying structural and functional homology to NF-kappa B p50/p105.
DNA and cell biology 1992;11(7):523-37.
1992: Tony Hunter; Michael Karin
The regulation of transcription by phosphorylation.
Cell 1992;70(3):375-87.
1992: T Smeal; B Binetruy; Dan Mercola; A Grover-Bardwick; Gisela Heidecker; U R Rapp; Michael Karin
Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.
Molecular and cellular biology 1992;12(8):3507-13.
1992: M Hagiwara; ARTHUR S ALBERTS; Paul K Brindle; Judy L Meinkoth; James R Feramisco; T Deng; Michael Karin; Shirish Shenolikar; Marc Montminy
Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB.
Cell 1992;70(1):105-13.
1992: L E Theill; K Hattori; Lazzaro Domenico; Jose Luis Castrillo; Michael Karin
Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins.
The EMBO journal 1992;11(6):2261-9.
1992: Michael Karin
Signal transduction from cell surface to nucleus in development and disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(8):2581-90.
1992: Li Li; J C Chambard; Michael Karin; E N Olson
Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression.
Genes & development 1992;6(4):676-89.
1992: Peter Angel; Michael Karin
Specific members of the Jun protein family regulate collagenase expression in response to various extracellular stimuli.
Matrix (Stuttgart, Germany). Supplement 1992;1():156-64.
1991: T Smeal; B Binetruy; Dan Mercola; Michael J Birrer; Michael Karin
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73.
Nature 1991;354(6353):494-6.
1991: Peter Angel; Michael Karin
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Biochimica et biophysica acta 1991;1072(2-3):129-57.
1991: Rhoda M Alani; P Brown; B Binétruy; H Dosaka; R K Rosenberg; P Angel; Michael Karin; Michael J Birrer
The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells.
Molecular and cellular biology 1991;11(12):6286-95.
1991: H F Yang-Yen; Xiao-kun Zhang; G Graupner; M Tzukerman; B Sakamoto; Michael Karin; Magnus Pfahl
Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation.
The New biologist 1991;3(12):1206-19.
1991: A McCormick; H Brady; J Fukushima; Michael Karin
The pituitary-specific regulatory gene GHF1 contains a minimal cell type-specific promoter centered around its TATA box.
Genes & development 1991;5(8):1490-503.
1991: Jose Luis Castrillo; L E Theill; Michael Karin
Function of the homeodomain protein GHF1 in pituitary cell proliferation.
Science (New York, N.Y.) 1991;253(5016):197-9.
1991: Michael Karin
Signal transduction and gene control.
Current opinion in cell biology 1991;3(3):467-73.
1991: B Binétruy; T Smeal; Michael Karin
Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain.
Nature 1991;351(6322):122-7.
1991: Y Devary; Roberta Anne Gottlieb; Lester F Lau; Michael Karin
Rapid and preferential activation of the c-jun gene during the mammalian UV response.
Molecular and cellular biology 1991;11(5):2804-11.
1991: william boyle; T Smeal; Bas Defize; Peter Angel; J R Woodgett; Michael Karin; Tony Hunter
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.
Cell 1991;64(3):573-84.
1990: Michael Karin; L Theill; Jose Luis Castrillo; A McCormick; H Brady
Cell type specific expression of the growth hormone gene and its control by GHF-1.
Nihon Naibunpi Gakkai zasshi 1990;66(12):1205-20.
1990: M Hattori; A Tugores; L Veloz; Michael Karin; David A Brenner
A simplified method for the preparation of transcriptionally active liver nuclear extracts.
DNA and cell biology 1990;9(10):777-81.
1990: Michael Karin
Transcriptional control and the integration of cell-autonomous and environmental cues during development.
Current opinion in cell biology 1990;2(6):996-1002.
1990: Adrian K West; R Stallings; C E Hildebrand; R Chiu; Michael Karin; R I Richards
Human metallothionein genes: structure of the functional locus at 16q13.
Genomics 1990;8(3):513-8.
1990: F William; F Wagner; Michael Karin; Andrew Kraft
Multiple doses of diacylglycerol and calcium ionophore are necessary to activate AP-1 enhancer activity and induce markers of macrophage differentiation.
The Journal of biological chemistry 1990;265(30):18166-71.
1990: H F Yang-Yen; J C Chambard; Y L Sun; T Smeal; T J Schmidt; J Drouin; Michael Karin
Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction.
Cell 1990;62(6):1205-15.
1990: C Buchman; P Skroch; W Dixon; T D Tullius; Michael Karin
A single amino acid change in CUP2 alters its mode of DNA binding.
Molecular and cellular biology 1990;10(9):4778-87.
1990: Robert Lafyatis; Seong-Jin Kim; P Angel; Anita B Roberts; Michael B. Sporn; Michael Karin; Ronald L Wilder
Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5' activator protein-1-binding site.
Molecular endocrinology (Baltimore, Md.) 1990;4(7):973-80.
1990: A McCormick; H Brady; L E Theill; Michael Karin
Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues.
Nature 1990;345(6278):829-32.
1990: A Radler-Pohl; I Pfeuffer; Michael Karin; Edgar Serfling
A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter.
The New biologist 1990;2(6):566-73.
1990: Bernd Kaina; H Lohrer; Michael Karin; Peter Herrlich
Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2710-4.
1990: E A Allegretto; T Smeal; Peter Angel; Bruce M Spiegelman; Michael Karin
DNA-binding activity of Jun is increased through its interaction with Fos.
Journal of cellular biochemistry 1990;42(4):193-206.
1990: Seong-Jin Kim; P Angel; Robert Lafyatis; K Hattori; K Y Kim; Michael B. Sporn; Michael Karin; Anita B Roberts
Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.
Molecular and cellular biology 1990;10(4):1492-7.
1990: H F Yang-Yen; R Chiu; Michael Karin
Elevation of AP1 activity during F9 cell differentiation is due to increased c-jun transcription.
The New biologist 1990;2(4):351-61.
1990: Pascal Dollé; Jose Luis Castrillo; L E Theill; Thomas J Deerinck; M Ellisman; Michael Karin
Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity.
Cell 1990;60(5):809-20.
1990: Michael Karin; Jose Luis Castrillo; L E Theill
Growth hormone gene regulation: a paradigm for cell-type-specific gene activation.
Trends in genetics : TIG 1990;6(3):92-6.
1990: Michael Karin
Too many transcription factors: positive and negative interactions.
The New biologist 1990;2(2):126-31.
1990: Seong-Jin Kim; Robert Lafyatis; K Y Kim; P Angel; H Fujiki; Michael Karin; Michael B. Sporn; Anita B Roberts
Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases.
Cell regulation 1990;1(3):269-78.
1990: Michael Karin; L Theill; Jose Luis Castrillo; A McCormick; H Brady
Tissue-specific expression of the growth hormone gene and its control by growth hormone factor-1.
Recent progress in hormone research 1990;46():43-57; discussion 57-8.
1990: Hyam L Leffert; Katherine S Koch; X P Lu; David A Brenner; Michael Karin; H F Skelly; Richard A Rippe; G Fey; M Chojkier
Cellular and molecular biology of hepatocyte growth, regeneration and gene expression.
Advances in second messenger and phosphoprotein research 1990;24():352-8.
1989: R Chiu; Peter Angel; Michael Karin
Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun.
Cell 1989;59(6):979-86.
1989: L E Theill; Jose Luis Castrillo; D Wu; Michael Karin
Dissection of functional domains of the pituitary-specific transcription factor GHF-1.
Nature 1989;342(6252):945-8.
1989: T Smeal; Peter Angel; J Meek; Michael Karin
Different requirements for formation of Jun: Jun and Jun: Fos complexes.
Genes & development 1989;3(12B):2091-100.
1989: Kathrin Muegge; T M Williams; J Kant; Michael Karin; R Chiu; A Schmidt; U Siebenlist; Howard A Young; Scott K Durum
Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1.
Science (New York, N.Y.) 1989;246(4927):249-51.
1989: Peter Angel; T Smeal; J Meek; Michael Karin
Jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner.
The New biologist 1989;1(1):35-43.
1989: C Buchman; P Skroch; J Welch; S Fogel; Michael Karin
The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein.
Molecular and cellular biology 1989;9(9):4091-5.
1989: F Mercurio; Michael Karin
Transcription factors AP-3 and AP-2 interact with the SV40 enhancer in a mutually exclusive manner.
The EMBO journal 1989;8(5):1455-60.
1989: S Dana; Michael Karin
Induction of human growth hormone promoter activity by the adenosine 3',5'-monophosphate pathway involves a novel responsive element.
Molecular endocrinology (Baltimore, Md.) 1989;3(5):815-21.
1989: A Schönthal; M Büscher; Peter Angel; HJ Rahmsdorf; Helmut Ponta; K Hattori; R Chiu; Michael Karin; Peter Herrlich
The Fos and Jun/AP-1 proteins are involved in the downregulation of Fos transcription.
Oncogene 1989;4(5):629-36.
1989: Michael Karin
Complexities of gene regulation by cAMP.
Trends in genetics : TIG 1989;5(3):65-7.
1989: David A Brenner; M O'Hara; P Angel; M Chojkier; Michael Karin
Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha.
Nature 1989;337(6208):661-3.
1989: Jose Luis Castrillo; M Bodner; Michael Karin
Purification of growth hormone-specific transcription factor GHF-1 containing homeobox.
Science (New York, N.Y.) 1989;243(4892):814-7.
1989: Edgar Serfling; R Barthelmäs; I Pfeuffer; B Schenk; S Zarius; R Swoboda; F Mercurio; Michael Karin
Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes.
The EMBO journal 1989;8(2):465-73.
1989: J Welch; S Fogel; C Buchman; Michael Karin
The CUP2 gene product regulates the expression of the CUP1 gene, coding for yeast metallothionein.
The EMBO journal 1989;8(1):255-60.
1988: Thomas H Haugen; Lubomir P Turek; F M Mercurio; Timothy P Cripe; B J Olson; R D Anderson; D Seidl; Michael Karin; J Schiller
Sequence-specific and general transcriptional activation by the bovine papillomavirus-1 E2 trans-activator require an N-terminal amphipathic helix-containing E2 domain.
The EMBO journal 1988;7(13):4245-53.
1988: Peter Angel; K Hattori; T Smeal; Michael Karin
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1.
Cell 1988;55(5):875-85.
1988: K Hattori; Peter Angel; M M Le Beau; Michael Karin
Structure and chromosomal localization of the functional intronless human JUN protooncogene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9148-52.
1988: M Bodner; Jose Luis Castrillo; L E Theill; Thomas J Deerinck; M Ellisman; Michael Karin
The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein.
Cell 1988;55(3):505-18.
1988: A McCormick; D Wu; Jose Luis Castrillo; S Dana; J Strobl; E B Thompson; Michael Karin
Extinction of growth hormone expression in somatic cell hybrids involves repression of the specific trans-activator GHF-1.
Cell 1988;55(2):379-89.
1988: T W Hai; F Liu; E A Allegretto; Michael Karin; M R Green
A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1.
Genes & development 1988;2(10):1216-26.
1988: M Büscher; HJ Rahmsdorf; M Litfin; Michael Karin; Peter Herrlich
Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element.
Oncogene 1988;3(3):301-11.
1988: R Chiu; william boyle; J Meek; T Smeal; Tony Hunter; Michael Karin
The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes.
Cell 1988;54(4):541-52.
1988: E P Slater; A C Cato; Michael Karin; J D Baxter; Miguel Beato
Progesterone induction of metallothionein-IIA gene expression.
Molecular endocrinology (Baltimore, Md.) 1988;2(6):485-91.
1988: M A Harrington; Peter A Jones; M Imagawa; Michael Karin
Cytosine methylation does not affect binding of transcription factor Sp1.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(7):2066-70.
1988: Peter Angel; E A Allegretto; S T Okino; K Hattori; william boyle; Tony Hunter; Michael Karin
Oncogene jun encodes a sequence-specific trans-activator similar to AP-1.
Nature 1988;332(6160):166-71.
1988: Tony Hunter; Peter Angel; william boyle; R Chiu; E Freed; K L Gould; C M Isacke; Michael Karin; R A Lindberg; P van der Geer
Targets for signal-transducing protein kinases.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():131-42.
1987: H Dinter; R Chiu; M Imagawa; Michael Karin; K A Jones
In vitro activation of the HIV-1 enhancer in extracts from cells treated with a phorbol ester tumor promoter.
The EMBO journal 1987;6(13):4067-71.
1987: M Imagawa; R Chiu; Michael Karin
Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP.
Cell 1987;51(2):251-60.
1987: R Chiu; M Imagawa; R J Imbra; J R Bockoven; Michael Karin
Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters.
Nature 1987;329(6140):648-51.
1987: M Bodner; Michael Karin
A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells.
Cell 1987;50(2):267-75.
1987: Peter Angel; M Imagawa; R Chiu; B Stein; R J Imbra; HJ Rahmsdorf; C Jonat; Peter Herrlich; Michael Karin
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor.
Cell 1987;49(6):729-39.
1987: Seymour Packman; R D Palmiter; Michael Karin; C O'Toole
Metallothionein messenger RNA regulation in the mottled mouse and Menkes kinky hair syndrome.
The Journal of clinical investigation 1987;79(5):1338-42.
1987: R J Imbra; Michael Karin
Metallothionein gene expression is regulated by serum factors and activators of protein kinase C.
Molecular and cellular biology 1987;7(4):1358-63.
1987: C Lefevre; M Imagawa; S Dana; J Grindlay; M Bodner; Michael Karin
Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.
The EMBO journal 1987;6(4):971-81.
1987: Michael Karin; A Haslinger; A Heguy; Therese A Dietlin; T Cooke
Metal-responsive elements act as positive modulators of human metallothionein-IIA enhancer activity.
Molecular and cellular biology 1987;7(2):606-13.
1987: W Lee; A Haslinger; Michael Karin; Robert Tjian
Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40.
Nature 1987;325(6102):368-72.
1987: Thomas H Haugen; Timothy P Cripe; G D Ginder; Michael Karin; Lubomir P Turek
Trans-activation of an upstream early gene promoter of bovine papilloma virus-1 by a product of the viral E2 gene.
The EMBO journal 1987;6(1):145-52.
1987: Michael Karin; A Haslinger; A Heguy; Therese A Dietlin; R Imbra
Transcriptional control mechanisms which regulate the expression of human metallothionein genes.
Experientia. Supplementum 1987;52():401-5.
1986: R J Imbra; Michael Karin
Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer.
Nature 1986;323(6088):555-8.
1986: A Heguy; A West; R I Richards; Michael Karin
Structure and tissue-specific expression of the human metallothionein IB gene.
Molecular and cellular biology 1986;6(6):2149-57.
1986: H Scholer; A Haslinger; A Heguy; H Holtgreve; Michael Karin
In vivo competition between a metallothionein regulatory element and the SV40 enhancer.
Science (New York, N.Y.) 1986;232(4746):76-80.
1985: A Haslinger; Michael Karin
Upstream promoter element of the human metallothionein-IIA gene can act like an enhancer element.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(24):8572-6.
1985: E P Slater; O Rabenau; Michael Karin; J D Baxter; M Beato
Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene.
Molecular and cellular biology 1985;5(11):2984-92.
1985: Michael Karin; R J Imbra; A Heguy; G Wong
Interleukin 1 regulates human metallothionein gene expression.
Molecular and cellular biology 1985;5(10):2866-9.
1985: Michael Karin
Metallothioneins: proteins in search of function.
Cell 1985;41(1):9-10.
1985: M M Le Beau; M O Diaz; Michael Karin; J D Rowley
Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia.
Nature 1985;313(6004):709-11.
1985: E P Slater; T R Anderson; Peter A Cattini; Norman L Eberhardt; Michael Karin; Pamela L Mellon; J D Baxter
Tissue-specific influences affect glucocorticoid regulatory element actions on the human growth hormone gene promotor.
Transactions of the Association of American Physicians 1985;98():66-73.
1984: Michael Karin; R L Eddy; W M Henry; L L Haley; M G Byers; TB Shows
Human metallothionein genes are clustered on chromosome 16.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(17):5494-8.
1984: Michael Karin; H Holtgreve
Nucleotide sequence requirements for transient expression of human metallothionein-IIA-thymidine kinase fusion genes.
DNA (Mary Ann Liebert, Inc.) 1984;3(4):319-26.
1984: R I Richards; A Heguy; Michael Karin
Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids.
Cell 1984;37(1):263-72.
1984: Michael Karin; A Haslinger; H Holtgreve; R I Richards; P Krauter; H M Westphal; M Beato
Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene.
Nature 1984;308(5959):513-9.
1984: Michael Karin; R I Richards
The human metallothionein gene family: structure and expression.
Environmental health perspectives 1984;54():111-5.
1984: Michael Karin; A Haslinger; H Holtgreve; G Cathala; E Slater; J D Baxter
Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5'-flanking DNA.
Cell 1984;36(2):371-9.
1984: Michael Karin; Norman L Eberhardt; Synthia H Mellon; N Malich; R I Richards; E P Slater; A Barta; J A Martial; J D Baxter; G Cathala
Expression and hormonal regulation of the rat growth hormone gene in transfected mouse L cells.
DNA (Mary Ann Liebert, Inc.) 1984;3(2):147-55.
1984: N C Lan; Michael Karin; T Nguyen; A Weisz; M J Birnbaum; N L Eberhardt; J D Baxter
Mechanisms of glucocorticoid hormone action.
Journal of steroid biochemistry 1984;20(1):77-88.
1984: Michael Karin; R Najarian; A Haslinger; P Valenzuela; J Welch; S Fogel
Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(2):337-41.
1983: J W Welch; S Fogel; G Cathala; Michael Karin
Industrial yeasts display tandem gene iteration at the CUP1 region.
Molecular and cellular biology 1983;3(8):1353-61.
1983: Michael Karin; G Cathala; M C Nguyen-Huu
Expression and regulation of a human metallothionein gene carried on an autonomously replicating shuttle vector.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(13):4040-4.
1983: G Cathala; J F Savouret; B Mendez; Brian L West; Michael Karin; J A Martial; J D Baxter
A method for isolation of intact, translationally active ribonucleic acid.
DNA (Mary Ann Liebert, Inc.) 1983;2(4):329-35.
1982: Michael Karin; R I Richards
Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene.
Nature 1982;299(5886):797-802.
1982: Michael Karin; R I Richards
Human metallothionein genes: molecular cloning and sequence analysis of the mRNA.
Nucleic acids research 1982;10(10):3165-73.
1981: Michael Karin; R D Andersen; harvey Herschman
Induction of metallothionein mRNA in HeLa cells by dexamethasone and by heavy metals.
European journal of biochemistry / FEBS 1981;118(3):527-31.
1981: Michael Karin; B Mintz
Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells.
The Journal of biological chemistry 1981;256(7):3245-52.
1981: Michael Karin; harvey Herschman
Induction of metallothionein in HeLa cells by dexamethasone and zinc.
European journal of biochemistry / FEBS 1981;113(2):267-72.
1981: Michael Karin; E P Slater; harvey Herschman
Regulation of metallothionein synthesis in HeLa cells by heavy metals and glucocorticoids.
Journal of cellular physiology 1981;106(1):63-74.
1980: Michael Karin; R D Andersen; E Slater; K Smith; harvey Herschman
Metallothionein mRNA induction in HeLa cells in response to zinc or dexamethasone is a primary induction response.
Nature 1980;286(5770):295-7.
1980: Michael Karin; harvey Herschman
Characterization of the metallothioneins induced in HeLa cells by dexamethasone and zinc.
European journal of biochemistry / FEBS 1980;107(2):395-401.
1980: Michael Karin; harvey Herschman
Glucocorticoid hormone receptor mediated induction of metallothionein synthesis in HeLa cells.
Journal of cellular physiology 1980;103(1):35-40.
1980: Michael Karin; harvey Herschman; D Weinstein
Primary induction of metallothionein by dexamethasone in culture rat hepatocytes.
Biochemical and biophysical research communications 1980;92(3):1052-69.
1979: Michael Karin; harvey Herschman
Dexamethasone stimulation of metallothionein synthesis in HeLa cell cultures.
Science (New York, N.Y.) 1979;204(4389):176-7.