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Michael Karin

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Haybaeck Johannes; Zeller Nicolas; Wolf Monika Julia; Weber Achim; Wagner Ulrich; Kurrer Michael Odo; Bremer Juliane; Iezzi Giandomenica; Graf Rolf; Clavien Pierre-Alain; Thimme Robert; Blum Hubert; Nedospasov Sergei A; Zatloukal Kurt; Ramzan Muhammad; Ciesek Sandra; Pietschmann Thomas; Marche Patrice N; Karin Michael; Kopf Manfred; Browning Jeffrey L; Aguzzi Adriano; Heikenwalder Mathias
A lymphotoxin-driven pathway to hepatocellular carcinoma.
Enzler Thomas; Chang Xing; Facchinetti Valeria; Melino Gerry; Karin Michael; Su Bing; Gallagher Ewen
MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression.
Hruz Petr; Zinkernagel Annelies S; Jenikova Gabriela; Botwin Gregory J; Hugot Jean-Pierre; Karin Michael; Nizet Victor; Eckmann Lars
NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation.

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All Publications

2009: Haybaeck Johannes; Zeller Nicolas; Wolf Monika Julia; Weber Achim; Wagner Ulrich; Kurrer Michael Odo; Bremer Juliane; Iezzi Giandomenica; Graf Rolf; Clavien Pierre-Alain; Thimme Robert; Blum Hubert; Nedospasov Sergei A; Zatloukal Kurt; Ramzan Muhammad; Ciesek Sandra; Pietschmann Thomas; Marche Patrice N; Karin Michael; Kopf Manfred; Browning Jeffrey L; Aguzzi Adriano; Heikenwalder Mathias
A lymphotoxin-driven pathway to hepatocellular carcinoma.
Cancer cell 2009;16(4):295-308.
2009: Enzler Thomas; Chang Xing; Facchinetti Valeria; Melino Gerry; Karin Michael; Su Bing; Gallagher Ewen
MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3831-8.
2009: Hruz Petr; Zinkernagel Annelies S; Jenikova Gabriela; Botwin Gregory J; Hugot Jean-Pierre; Karin Michael; Nizet Victor; Eckmann Lars
NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12873-8.
2009: Guma Monica; Rius Jordi; Duong-Polk Karen X; Haddad Gabriel G; Lindsey James D; Karin Michael
Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(21):8760-5.
2009: Karin Michael; Gallagher Ewen
TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes.
Immunological reviews 2009;228(1):225-40.
2009: Koch Katherine S; Maeda Shin; He Guobin; Karin Michael; Leffert Hyam L
Targeted deletion of hepatocyte Ikkbeta confers growth advantages.
Biochemical and biophysical research communications 2009;380(2):349-54.
2009: Chu Wen-Ming; Gong Xing; Li Zhi-Wei; Takabayashi Kenji; Ouyang Hong-Hai; Chen Yi; Chen David J; Li Gloria C; Karin Michael; Raz Eyal
Retraction: DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA.
Cell 2009;136(3):565.
2009: Grivennikov Sergei; Karin Eliad; Terzic Janos; Mucida Daniel; Yu Guann-Yi; Vallabhapurapu Sivakumar; Scheller Jürgen; Rose-John Stefan; Cheroutre Hilde; Eckmann Lars; Karin Michael
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.
Cancer cell 2009;15(2):103-13.
2009: Kim Sunhwa; Takahashi Hiroyuki; Lin Wan-Wan; Descargues Pascal; Grivennikov Sergei; Kim Youngjun; Luo Jun-Li; Karin Michael
Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis.
Nature 2009;457(7225):102-6.
2009: Baud Véronique; Karin Michael
Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls.
Nature reviews. Drug discovery 2009;8(1):33-40.
2009: Timmer Anjuli M; Timmer John C; Pence Morgan A; Hsu Li-Chung; Ghochani Mariam; Frey Terrence G; Karin Michael; Salvesen Guy S; Nizet Victor
Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis.
The Journal of biological chemistry 2009;284(2):862-71.
2009: Marinari Barbara; Ballaro Costanza; Koster Maranke I; Giustizieri Maria Laura; Moretti Francesca; Crosti Francesca; Papoutsaki Marina; Karin Michael; Alema Stefano; Chimenti Sergio; Roop Dennis R; Costanzo Antonio
IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias.
The Journal of investigative dermatology 2009;129(1):60-9.
2009: Darash-Yahana Merav; Gillespie John W; Hewitt Stephen M; Chen Yun-Yun K; Maeda Shin; Stein Ilan; Singh Satya P; Bedolla Roble B; Peled Amnon; Troyer Dean A; Pikarsky Eli; Karin Michael; Farber Joshua M
The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers.
PloS one 2009;4(8):e6695.
2009: Vallabhapurapu Sivakumar; Karin Michael
Regulation and function of NF-kappaB transcription factors in the immune system.
Annual review of immunology 2009;27():693-733.
2008: Wang Haopeng; Matsuzawa Atsushi; Brown Scott A; Zhou JingRan; Guy Cliff S; Tseng Ping-Hui; Forbes Karen; Nicholson Thomas P; Sheppard Paul W; Häcker Hans; Karin Michael; Vignali Dario A A
Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(51):20197-202.
2008: Vallabhapurapu Sivakumar; Matsuzawa Atsushi; Zhang Weizhou; Tseng Ping-Hui; Keats Jonathan J; Wang Haopeng; Vignali Dario A A; Bergsagel P Leif; Karin Michael
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.
Nature immunology 2008;9(12):1364-70.
2008: Marinari Barbara; Moretti Francesca; Botti Elisabetta; Giustizieri Maria Laura; Descargues Pascal; Giunta Alessandro; Stolfi Carmine; Ballaro Costanza; Papoutsaki Marina; Alemà Stefano; Monteleone Giovanni; Chimenti Sergio; Karin Michael; Costanzo Antonio
The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(44):17091-6.
2008: Cho Ik-Hyun; Hong Jinpyo; Suh Eun Cheng; Kim Jae Hwan; Lee Hyunkyoung; Lee Jong Eun; Lee Soojin; Kim Chong-Hyun; Kim Dong Woon; Jo Eun-Kyeong; Lee Kyung Eun; Karin Michael; Lee Sung Joong
Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death.
Brain : a journal of neurology 2008;131(Pt 11):3019-33.
2008: Sun B; Karin M
NF-kappaB signaling, liver disease and hepatoprotective agents.
Oncogene 2008;27(48):6228-44.
2008: Stebbins John L; De Surya K; Machleidt Thomas; Becattini Barbara; Vazquez Jesus; Kuntzen Christian; Chen Li-Hsing; Cellitti Jason F; Riel-Mehan Megan; Emdadi Aras; Solinas Giovanni; Karin Michael; Pellecchia Maurizio
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(43):16809-13.
2008: Zhang Xiaoqing; Zhang Guo; Zhang Hai; Karin Michael; Bai Hua; Cai Dongsheng
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity.
Cell 2008;135(1):61-73.
2008: Descargues Pascal; Sil Alok K; Karin Michael
IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer.
The EMBO journal 2008;27(20):2639-47.
2008: Hou Yanjun; Li Fu; Karin Michael; Ostrowski Michael C
Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(10):2926-35.
2008: Nakagawa Hayato; Maeda Shin; Hikiba Yohko; Ohmae Tomoya; Shibata Wataru; Yanai Ayako; Sakamoto Kei; Ogura Keiji; Noguchi Takuya; Karin Michael; Ichijo Hidenori; Omata Masao
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
Gastroenterology 2008;135(4):1311-21.
2008: Eckmann Lars; Nebelsiek Tim; Fingerle Alexander A; Dann Sara M; Mages Jörg; Lang Roland; Robine Sylvie; Kagnoff Martin F; Schmid Roland M; Karin Michael; Arkan Melek C; Greten Florian R
Opposing functions of IKKbeta during acute and chronic intestinal inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):15058-63.
2008: Budanov Andrei V; Karin Michael
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
Cell 2008;134(3):451-60.
2008: Sakurai Toshiharu; He Guobin; Matsuzawa Atsushi; Yu Guann-Yi; Maeda Shin; Hardiman Gary; Karin Michael
Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis.
Cancer cell 2008;14(2):156-65.
2008: Matsuzawa Atsushi; Tseng Ping-Hui; Vallabhapurapu Sivakumar; Luo Jun-Li; Zhang Weizhou; Wang Haopeng; Vignali Dario A A; Gallagher Ewen; Karin Michael
Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.
Science (New York, N.Y.) 2008;321(5889):663-8.
2008: Bernassola Francesca; Karin Michael; Ciechanover Aaron; Melino Gerry
The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
Cancer cell 2008;14(1):10-21.
2008: Shibata Wataru; Maeda Shin; Hikiba Yohko; Yanai Ayako; Sakamoto Kei; Nakagawa Hayato; Ogura Keiji; Karin Michael; Omata Masao
c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice.
Cancer research 2008;68(13):5031-9.
2008: Hsu Li-Chung; Ali Syed R; McGillivray Shauna; Tseng Ping-Hui; Mariathasan Sanjeev; Humke Eric W; Eckmann Lars; Powell Jonathan J; Nizet Victor; Dixit Vishva M; Karin Michael
A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(22):7803-8.
2008: Fong Carol Ho Yan; Bebien Magali; Didierlaurent Arnaud; Nebauer Ruth; Hussell Tracy; Broide David; Karin Michael; Lawrence Toby
An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation.
The Journal of experimental medicine 2008;205(6):1269-76.
2008: Julius C; Heikenwalder M; Schwarz P; Marcel A; Karin M; Prinz M; Pasparakis M; Aguzzi A
Prion propagation in mice lacking central nervous system NF-kappaB signalling.
The Journal of general virology 2008;89(Pt 6):1545-50.
2008: Rius Jordi; Guma Monica; Schachtrup Christian; Akassoglou Katerina; Zinkernagel Annelies S; Nizet Victor; Johnson Randall S; Haddad Gabriel G; Karin Michael
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha.
Nature 2008;453(7196):807-11.
2008: Karin Michael
The IkappaB kinase - a bridge between inflammation and cancer.
Cell research 2008;18(3):334-42.
2008: Naugler Willscott E; Karin Michael
The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer.
Trends in molecular medicine 2008;14(3):109-19.
2008: Naugler Willscott E; Karin Michael
NF-kappaB and cancer-identifying targets and mechanisms.
Current opinion in genetics & development 2008;18(1):19-26.
2008: Herrlich Peter; Karin Michael; Weiss Carsten
Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response.
Molecular cell 2008;29(3):279-90.
2008: Descargues Pascal; Sil Alok K; Sano Yuji; Korchynskyi Olexandr; Han Gangwen; Owens Philip; Wang Xiao-Jing; Karin Michael
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2487-92.
2008: Grivennikov Sergei; Karin Michael
Autocrine IL-6 signaling: a key event in tumorigenesis?
Cancer cell 2008;13(1):7-9.
2008: Meinzer Ulrich; Esmiol-Welterlin Sophie; Barreau Frederick; Berrebi Dominique; Dussaillant Monique; Bonacorsi Stephane; Chareyre Fabrice; Niwa-Kawakita Michiko; Alberti Corinne; Sterkers Ghislaine; Villard Claude; Lesuffleur Thecla; Peuchmaur Michel; Karin Michael; Eckmann Lars; Giovannini Marco; Ollendorff Vincent; Wolf-Watz Hans; Hugot Jean-Pierre
Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice.
PloS one 2008;3(7):e2769.
2007: Temkin Vladislav; Karin Michael
From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey.
Immunological reviews 2007;220():8-21.
2007: Solinas Giovanni; Vilcu Cristian; Neels Jaap G; Bandyopadhyay Gautam K; Luo Jun-Li; Naugler Willscott; Grivennikov Sergei; Wynshaw-Boris Anthony; Scadeng Miriam; Olefsky Jerrold M; Karin Michael
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity.
Cell metabolism 2007;6(5):386-97.
2007: Karin Michael
Rsk Tolls the bell for endocytosis in DCs.
Nature immunology 2007;8(11):1197-9.
2007: Drew Devin; Shimada Eriko; Huynh Kim; Bergqvist Simon; Talwar Rashmi; Karin Michael; Ghosh Gourisankar
Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma.
Biochemistry 2007;46(43):12482-90.
2007: Cao Yixue; Luo Jun-Li; Karin Michael
IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(40):15852-7.
2007: Greten Florian R; Arkan Melek C; Bollrath Julia; Hsu Li-Chung; Goode Jason; Miething Cornelius; Göktuna Serkan I; Neuenhahn Michael; Fierer Joshua; Paxian Stephan; Van Rooijen Nico; Xu Yajun; O'Cain Timothy; Jaffee Bruce B; Busch Dirk H; Duyster Justus; Schmid Roland M; Eckmann Lars; Karin Michael
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.
Cell 2007;130(5):918-31.
2007: Van Waes Carter; Yu Ming; Nottingham Liesl; Karin Michael
Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(17):4956-9.
2007: Naugler Willscott E; Sakurai Toshiharu; Kim Sunhwa; Maeda Shin; Kim Kyounghyun; Elsharkawy Ahmed M; Karin Michael
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production.
Science (New York, N.Y.) 2007;317(5834):121-4.
2007: Lin Wan-Wan; Karin Michael
A cytokine-mediated link between innate immunity, inflammation, and cancer.
The Journal of clinical investigation 2007;117(5):1175-83.
2007: Chen Lee-Wei; Chen Pei-Hsuan; Chang Wei-Jung; Wang Jyh-Seng; Karin Michael; Hsu Ching-Mei
IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation.
Critical care medicine 2007;35(5):1332-40.
2007: Mills David M; Bonizzi Giuseppina; Karin Michael; Rickert Robert C
Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6359-64.
2007: Acharyya Swarnali; Villalta S Armando; Bakkar Nadine; Bupha-Intr Tepmanas; Janssen Paul M L; Carathers Micheal; Li Zhi-Wei; Beg Amer A; Ghosh Sankar; Sahenk Zarife; Weinstein Michael; Gardner Katherine L; Rafael-Fortney Jill A; Karin Michael; Tidball James G; Baldwin Albert S; Guttridge Denis C
Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.
The Journal of clinical investigation 2007;117(4):889-901.
2007: Luo Jun-Li; Tan Wei; Ricono Jill M; Korchynskyi Olexandr; Zhang Ming; Gonias Steven L; Cheresh David A; Karin Michael
Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.
Nature 2007;446(7136):690-4.
2007: Zaph Colby; Troy Amy E; Taylor Betsy C; Berman-Booty Lisa D; Guild Katherine J; Du Yurong; Yost Evan A; Gruber Achim D; May Michael J; Greten Florian R; Eckmann Lars; Karin Michael; Artis David
Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis.
Nature 2007;446(7135):552-6.
2007: Lickteig Andrew J; Slitt Angela L; Arkan Melek C; Karin Michael; Cherrington Nathan J
Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(3):402-9.
2007: Koster Maranke I; Dai Daisy; Marinari Barbara; Sano Yuji; Costanzo Antonio; Karin Michael; Roop Dennis R
p63 induces key target genes required for epidermal morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3255-60.
2007: Kim Sunshin; Millet Isabelle; Kim Hun Sik; Kim Ja Young; Han Myoung Sook; Lee Moon-Kyu; Kim Kwang-Won; Sherwin Robert S; Karin Michael; Lee Myung-Shik
NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):1913-8.
2007: Lin R; Maeda S; Liu C; Karin M; Edgington T S
A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas.
Oncogene 2007;26(6):851-8.
2007: Gallagher Ewen; Enzler Thomas; Matsuzawa Atsushi; Anzelon-Mills Amy; Otero Dennis; Holzer Ryan; Janssen Edith; Gao Min; Karin Michael
Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production.
Nature immunology 2007;8(1):57-63.
2007: Endo Tomoyuki; Nishio Mitsufumi; Enzler Thomas; Cottam Howard B; Fukuda Tetsuya; James Danelle F; Karin Michael; Kipps Thomas J
BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway.
Blood 2007;109(2):703-10.
2007: Ruocco Maria Grazia; Karin Michael
Control of osteoclast activity and bone loss by IKK subunits: new targets for therapy.
Advances in experimental medicine and biology 2007;602():125-34.
2006: Chen Fei; Lu Yongju; Castranova Vince; Li Zhiwei; Karin Michael
Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells.
The Journal of biological chemistry 2006;281(48):37142-9.
2006: Karin Michael
Role for IKK2 in muscle: waste not, want not.
The Journal of clinical investigation 2006;116(11):2866-8.
2006: Lu Ziyue; Serghides Lena; Patel Samir N; Degousee Norbert; Rubin Barry B; Krishnegowda Gowdahali; Gowda D Channe; Karin Michael; Kain Kevin C
Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6344-52.
2006: Solinas Giovanni; Naugler Willscott; Galimi Francesco; Lee Myung-Shik; Karin Michael
Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16454-9.
2006: Häcker Hans; Karin Michael
Regulation and function of IKK and IKK-related kinases.
Science's STKE : signal transduction knowledge environment 2006;2006(357):re13.
2006: Enzler Thomas; Bonizzi Giuseppina; Silverman Gregg J; Otero Dennis C; Widhopf George F; Anzelon-Mills Amy; Rickert Robert C; Karin Michael
Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease.
Immunity 2006;25(3):403-15.
2006: Labuda Tord; Christensen Jan Pravsgaard; Rasmussen Susanne; Bonnesen Barbara; Karin Michael; Thomsen Allan Randrup; Odum Niels
MEK kinase 1 is a negative regulator of virus-specific CD8(+) T cells.
European journal of immunology 2006;36(8):2076-84.
2006: Meylan Etienne; Tschopp Jürg; Karin Michael
Intracellular pattern recognition receptors in the host response.
Nature 2006;442(7098):39-44.
2006: Tuncman Gürol; Hirosumi Jiro; Solinas Giovanni; Chang Lufen; Karin Michael; Hotamisligil Gökhan S
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10741-6.
2006: Chae Sungwon; Eckmann Lars; Miyamoto Yukiko; Pothoulakis Charalabos; Karin Michael; Kagnoff Martin F
Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1214-20.
2006: Sakurai Toshiharu; Maeda Shin; Chang Lufen; Karin Michael
Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10544-51.
2006: Scheuner Donalyn; Patel Rupali; Wang Feng; Lee Kuei; Kumar Kotlo; Wu Jun; Nilsson Anders; Karin Michael; Kaufman Randal J
Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis.
The Journal of biological chemistry 2006;281(30):21458-68.
2006: Karin Michael
NF-kappaB and cancer: mechanisms and targets.
Molecular carcinogenesis 2006;45(6):355-61.
2006: Karin Michael
Nuclear factor-kappaB in cancer development and progression.
Nature 2006;441(7092):431-6.
2006: Venuprasad K; Elly Chris; Gao Min; Salek-Ardakani Shahram; Harada Yohsuke; Luo Jun-Li; Yang Chun; Croft Michael; Inoue Kazushi; Karin Michael; Liu Yun-Cai
Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation.
The Journal of clinical investigation 2006;116(4):1117-26.
2006: Karin Michael; Lawrence Toby; Nizet Victor
Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer.
Cell 2006;124(4):823-35.
2006: Chang Lufen; Kamata Hideaki; Solinas Giovanni; Luo Jun-Li; Maeda Shin; Venuprasad K; Liu Yun-Cai; Karin Michael
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.
Cell 2006;124(3):601-13.
2006: Guichard Annabel; Park Jin Mo; Cruz-Moreno Beatriz; Karin Michael; Bier Ethan
Anthrax lethal factor and edema factor act on conserved targets in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3244-9.
2006: Mahieu Tina; Park Jin Mo; Revets Hilde; Pasche Bastian; Lengeling Andreas; Staelens Jan; Wullaert Andy; Vanlaere Ineke; Hochepied Tino; van Roy Frans; Karin Michael; Libert Claude
The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2292-7.
2006: Gallagher Ewen; Gao Min; Liu Yun-Cai; Karin Michael
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1717-22.
2006: Häcker Hans; Redecke Vanessa; Blagoev Blagoy; Kratchmarova Irina; Hsu Li-Chung; Wang Gang G; Kamps Mark P; Raz Eyal; Wagner Hermann; Häcker Georg; Mann Matthias; Karin Michael
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6.
Nature 2006;439(7073):204-7.
2005: Briata Paola; Forcales Sonia Vanina; Ponassi Marco; Corte Giorgio; Chen Ching-Yi; Karin Michael; Puri Pier Lorenzo; Gherzi Roberto
p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts.
Molecular cell 2005;20(6):891-903.
2005: Liu Yun-Cai; Penninger Josef; Karin Michael
Immunity by ubiquitylation: a reversible process of modification.
Nature reviews. Immunology 2005;5(12):941-52.
2005: Broide David H; Lawrence Toby; Doherty Taylor; Cho Jae Youn; Miller Marina; McElwain Kirsti; McElwain Shauna; Karin Michael
Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(49):17723-8.
2005: Luo Jun-Li; Kamata Hideaki; Karin Michael
The anti-death machinery in IKK/NF-kappaB signaling.
Journal of clinical immunology 2005;25(6):541-50.
2005: Ruocco M G; Karin M
IKK{beta} as a target for treatment of inflammation induced bone loss.
Annals of the rheumatic diseases 2005;64 Suppl 4():iv81-5.
2005: Luo Jun-Li; Kamata Hideaki; Karin Michael
IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy.
The Journal of clinical investigation 2005;115(10):2625-32.
2005: Karin Michael; Greten Florian R
NF-kappaB: linking inflammation and immunity to cancer development and progression.
Nature reviews. Immunology 2005;5(10):749-59.
2005: Park Jin Mo; Greten Florian R; Wong Athena; Westrick Randal J; Arthur J Simon C; Otsu Kinya; Hoffmann Alexander; Montminy Marc; Karin Michael
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators.
Immunity 2005;23(3):319-29.
2005: Gao Min; Karin Michael
Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli.
Molecular cell 2005;19(5):581-93.
2005: Maeda Shin; Kamata Hideaki; Luo Jun-Li; Leffert Hyam; Karin Michael
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis.
Cell 2005;121(7):977-90.
2005: Eckmann Lars; Karin Michael
NOD2 and Crohn's disease: loss or gain of function?
Immunity 2005;22(6):661-7.
2005: Zhang Ping; Chan Justin; Dragoi Ana-Maria; Gong Xing; Ivanov Stanimir; Li Zhi-Wei; Chuang Tsung-Hsien; Tuthill Cynthia; Wan Yinsheng; Karin Michael; Chu Wen-Ming
Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway.
EMBO reports 2005;6(6):531-7.
2005: Ruocco Maria Grazia; Maeda Shin; Park Jin Mo; Lawrence Toby; Hsu Li-Chung; Cao Yixue; Schett Georg; Wagner Erwin F; Karin Michael
I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.
The Journal of experimental medicine 2005;201(10):1677-87.
2005: Karin Michael; Gallagher Ewen
From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance.
IUBMB life 2005;57(4-5):283-95.
2005: Lawrence Toby; Bebien Magali; Liu George Y; Nizet Victor; Karin Michael
IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation.
Nature 2005;434(7037):1138-43.
2005: Kamata Hideaki; Honda Shi-Ichi; Maeda Shin; Chang Lufen; Hirata Hajime; Karin Michael
Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases.
Cell 2005;120(5):649-61.
2005: Maeda Shin; Hsu Li-Chung; Liu Hongjun; Bankston Laurie A; Iimura Mitsutoshi; Kagnoff Martin F; Eckmann Lars; Karin Michael
Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing.
Science (New York, N.Y.) 2005;307(5710):734-8.
2005: Arkan Melek C; Hevener Andrea L; Greten Florian R; Maeda Shin; Li Zhi-Wei; Long Jeffrey M; Wynshaw-Boris Anthony; Poli Giuseppe; Olefsky Jerrold; Karin Michael
IKK-beta links inflammation to obesity-induced insulin resistance.
Nature medicine 2005;11(2):191-8.
2005: Karin Michael
Inflammation and cancer: the long reach of Ras.
Nature medicine 2005;11(1):20-1.
2005: Karin Michael
Inflammation-activated protein kinases as targets for drug development.
Proceedings of the American Thoracic Society 2005;2(4):386-90; discussion 394-5.
2004: Park Jin Mo; Ng Vincent H; Maeda Shin; Rest Richard F; Karin Michael
Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists.
The Journal of experimental medicine 2004;200(12):1647-55.
2004: Valledor Annabel F; Hsu Li-Chung; Ogawa Sumito; Sawka-Verhelle Dominique; Karin Michael; Glass Christopher K
Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(51):17813-8.
2004: Drayton Danielle L; Bonizzi Giuseppina; Ying Xiaoyan; Liao Shan; Karin Michael; Ruddle Nancy H
I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6161-8.
2004: Karin M
Mitogen activated protein kinases as targets for development of novel anti-inflammatory drugs.
Annals of the rheumatic diseases 2004;63 Suppl 2():ii62-ii64.
2004: Bonizzi Giuseppina; Bebien Magali; Otero Dennis C; Johnson-Vroom Kirsten E; Cao Yixue; Vu Don; Jegga Anil G; Aronow Bruce J; Ghosh Gourisankar; Rickert Robert C; Karin Michael
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers.
The EMBO journal 2004;23(21):4202-10.
2004: Gao Min; Labuda Tord; Xia Ying; Gallagher Ewen; Fang Deyu; Liu Yun-Cai; Karin Michael
Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch.
Science (New York, N.Y.) 2004;306(5694):271-5.
2004: Luo Jun-Li; Maeda Shin; Hsu Li-Chung; Yagita Hideo; Karin Michael
Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression.
Cancer cell 2004;6(3):297-305.
2004: Sabapathy Kanaga; Hochedlinger Konrad; Nam Shin Yuen; Bauer Anton; Karin Michael; Wagner Erwin F
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation.
Molecular cell 2004;15(5):713-25.
2004: Greten Florian R; Eckmann Lars; Greten Tim F; Park Jin Mo; Li Zhi-Wei; Egan Laurence J; Kagnoff Martin F; Karin Michael
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
Cell 2004;118(3):285-96.
2004: Lee Soojin; Hong Jinpyo; Choi Se-Young; Oh Seog Bae; Park Kyungpyo; Kim Joong Soo; Karin Michael; Lee Sung Joong
CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-kappaB activation.
Journal of neuroimmunology 2004;153(1-2):50-63.
2004: Li Zhi-Wei; Rickert Robert C; Karin Michael
Genetic dissection of antigen receptor induced-NF-kappaB activation.
Molecular immunology 2004;41(6-7):701-14.
2004: Shen Han-Ming; Lin Yong; Choksi Swati; Tran Jamie; Jin Tian; Chang Lufen; Karin Michael; Zhang Jianke; Liu Zheng-gang
Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death.
Molecular and cellular biology 2004;24(13):5914-22.
2004: Gherzi Roberto; Lee Kyung-Yeol; Briata Paola; Wegmüller Daniel; Moroni Christoph; Karin Michael; Chen Ching-Yi
A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.
Molecular cell 2004;14(5):571-83.
2004: Bonizzi Giuseppina; Karin Michael
The two NF-kappaB activation pathways and their role in innate and adaptive immunity.
Trends in immunology 2004;25(6):280-8.
2004: Galijatovic Alema; Beaton Deirdre; Nguyen Nghia; Chen Shujuan; Bonzo Jessica; Johnson Randall; Maeda Shin; Karin Michael; Guengerich F Peter; Tukey Robert H
The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice.
The Journal of biological chemistry 2004;279(23):23969-76.
2004: Sil Alok K; Maeda Shin; Sano Yuji; Roop Dennis R; Karin Michael
IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis.
Nature 2004;428(6983):660-4.
2004: Greten Florian R; Karin Michael
The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer.
Cancer letters 2004;206(2):193-9.
2004: Amir Ruthie E; Haecker Hans; Karin Michael; Ciechanover Aaron
Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase.
Oncogene 2004;23(14):2540-7.
2004: Park Jin Mo; Brady Helen; Ruocco Maria Grazia; Sun Huaiyu; Williams DeeAnn; Lee Susan J; Kato Tomohisa; Richards Normand; Chan Kyle; Mercurio Frank; Karin Michael; Wasserman Steven A
Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila.
Genes & development 2004;18(5):584-94.
2004: Hsu Li-Chung; Park Jin Mo; Zhang Kezhong; Luo Jun-Li; Maeda Shin; Kaufman Randal J; Eckmann Lars; Guiney Donald G; Karin Michael
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.
Nature 2004;428(6980):341-5.
2004: Xia Ying; Karin Michael
The control of cell motility and epithelial morphogenesis by Jun kinases.
Trends in cell biology 2004;14(2):94-101.
2004: Egan Laurence J; Eckmann Lars; Greten Florian R; Chae Sungwon; Li Zhi-Wei; Myhre Gennett M; Robine Sylvie; Karin Michael; Kagnoff Martin F
IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2452-7.
2004: Ohazama Atsushi; Hu Yinling; Schmidt-Ullrich Ruth; Cao Yixue; Scheidereit Claus; Karin Michael; Sharpe Paul T
A dual role for Ikk alpha in tooth development.
Developmental cell 2004;6(2):219-27.
2004: Karin Michael; Yamamoto Yumi; Wang Q May
The IKK NF-kappa B system: a treasure trove for drug development.
Nature reviews. Drug discovery 2004;3(1):17-26.
2003: Chen Fei; Castranova Vince; Li Zhiwei; Karin Michael; Shi Xianglin
Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic.
Cancer research 2003;63(22):7689-93.
2003: Maeda Shin; Chang Lufen; Li Zhi-Wei; Luo Jun-Li; Leffert Hyam; Karin Michael
IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha.
Immunity 2003;19(5):725-37.
2003: Fujita Fumitaka; Taniguchi Yuko; Kato Takashi; Narita Yasuko; Furuya Akiko; Ogawa Tatsuhiro; Sakurai Hiroaki; Joh Takashi; Itoh Makoto; Delhase Mireille; Karin Michael; Nakanishi Makoto
Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.
Molecular and cellular biology 2003;23(21):7780-93.
2003: Kato Tomohisa; Delhase Mireille; Hoffmann Alexander; Karin Michael
CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response.
Molecular cell 2003;12(4):829-39.
2003: Zhang Lin; Wang Wei; Hayashi Yasuhito; Jester James V; Birk David E; Gao Min; Liu Chia-Yang; Kao Winston W-Y; Karin Michael; Xia Ying
A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure.
The EMBO journal 2003;22(17):4443-54.
2003: Hayakawa Makio; Miyashita Hiroshi; Sakamoto Isao; Kitagawa Masatoshi; Tanaka Hirofumi; Yasuda Hideyo; Karin Michael; Kikugawa Kiyomi
Evidence that reactive oxygen species do not mediate NF-kappaB activation.
The EMBO journal 2003;22(13):3356-66.
2003: Li Zhi-Wei; Omori Sidne A; Labuda Tord; Karin Michael; Rickert Robert C
IKK beta is required for peripheral B cell survival and proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(9):4630-7.
2003: Shillingford Jonathan M; Miyoshi Keiko; Robinson Gertraud W; Bierie Brian; Cao Yixue; Karin Michael; Hennighausen Lothar
Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003;51(5):555-65.
2003: Chen Lee-Wei; Egan Laurence; Li Zhi-Wei; Greten Florian R; Kagnoff Martin F; Karin Michael
The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion.
Nature medicine 2003;9(5):575-81.
2003: Chen Shujuan; Nguyen Nghia; Tamura Kumiko; Karin Michael; Tukey Robert H
The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis.
The Journal of biological chemistry 2003;278(21):19526-33.
2003: Cao Yixue; Karin Michael
NF-kappaB in mammary gland development and breast cancer.
Journal of mammary gland biology and neoplasia 2003;8(2):215-23.
2003: Chang Lufen; Jones Ying; Ellisman Mark H; Goldstein Lawrence S B; Karin Michael
JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins.
Developmental cell 2003;4(4):521-33.
2003: Lin Anning; Karin Michael
NF-kappaB in cancer: a marked target.
Seminars in cancer biology 2003;13(2):107-14.
2003: Maeda Shin; Karin Michael
Oncogene at last--c-Jun promotes liver cancer in mice.
Cancer cell 2003;3(2):102-4.
2003: Bayon Yolanda; Ortiz Maria A; Lopez-Hernandez Francisco J; Gao Feng; Karin Michael; Pfahl Magnus; Piedrafita F Javier
Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis.
Molecular and cellular biology 2003;23(3):1061-74.
2002: Shim Jaekyung; Karin Michael
The control of mRNA stability in response to extracellular stimuli.
Molecules and cells 2002;14(3):323-31.
2002: Shim Jaekyung; Lim Hanjo; R Yates John; Karin Michael
Nuclear export of NF90 is required for interleukin-2 mRNA stabilization.
Molecular cell 2002;10(6):1331-44.
2002: Häcker Hans; Karin Michael
Is NF-kappaB2/p100 a direct activator of programmed cell death?
Cancer cell 2002;2(6):431-3.
2002: Hirosumi Jiro; Tuncman Gürol; Chang Lufen; Görgün Cem Z; Uysal K Teoman; Maeda Kazuhisa; Karin Michael; Hotamisligil Gökhan S
A central role for JNK in obesity and insulin resistance.
Nature 2002;420(6913):333-6.
2002: Dejardin Emmanuel; Droin Nathalie M; Delhase Mireille; Haas Elvira; Cao Yixue; Makris Constantin; Li Zhi-Wei; Karin Michael; Ware Carl F; Green Douglas R
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
Immunity 2002;17(4):525-35.
2002: Takanami-Ohnishi Yoko; Amano Shinya; Kimura Sadao; Asada Sachie; Utani Atsushi; Maruyama Masumi; Osada Hiroyuki; Tsunoda Hajime; Irukayama-Tomobe Yoko; Goto Katsutoshi; Karin Michael; Sudo Tatsuhiko; Kasuya Yoshitoshi
Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity.
The Journal of biological chemistry 2002;277(40):37896-903.
2002: Park Jin Mo; Greten Florian R; Li Zhi-Wei; Karin Michael
Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition.
Science (New York, N.Y.) 2002;297(5589):2048-51.
2002: Makris Constantin; Roberts Jaclyn L; Karin Michael
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.
Molecular and cellular biology 2002;22(18):6573-81.
2002: Wang Li; Lee Yoon-Kwang; Bundman Donnie; Han Yunqing; Thevananther Sundararajah; Kim Chang Soo; Chua Steven S; Wei Ping; Heyman Richard A; Karin Michael; Moore David D
Redundant pathways for negative feedback regulation of bile acid production.
Developmental cell 2002;2(6):721-31.
2002: Shaulian Eitan; Karin Michael
AP-1 as a regulator of cell life and death.
Nature cell biology 2002;4(5):E131-6.
2002: Yoshida Kazuhiko; Behrens Axcel; Le-Niculescu Helen; Wagner Erwin F; Harada Takayuki; Imaki Junko; Ohno Shigeaki; Karin Michael
Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection.
Investigative ophthalmology & visual science 2002;43(5):1631-5.
2002: Karin Michael; Cao Yixue; Greten Florian R; Li Zhi-Wei
NF-kappaB in cancer: from innocent bystander to major culprit.
Nature reviews. Cancer 2002;2(4):301-10.
2002: Ghosh Sankar; Karin Michael
Missing pieces in the NF-kappaB puzzle.
Cell 2002;109 Suppl():S81-96.
2002: Han Zuoning; Chang Lufen; Yamanishi Yuji; Karin Michael; Firestein Gary S
Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis.
Arthritis and rheumatism 2002;46(3):818-23.
2002: Karin Michael; Lin Anning
NF-kappaB at the crossroads of life and death.
Nature immunology 2002;3(3):221-7.
2002: Senftleben Uwe; Karin Michael
The IKK/NF-kappa B pathway.
Critical care medicine 2002;30(1 Suppl):S18-26.
2001: Cao Y; Bonizzi G; Seagroves T N; Greten F R; Johnson R; Schmidt E V; Karin M
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.
Cell 2001;107(6):763-75.
2001: Chen C Y; Gherzi R; Ong S E; Chan E L; Raijmakers R; Pruijn G J; Stoecklin G; Moroni C; Mann M; Karin M
AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.
Cell 2001;107(4):451-64.
2001: Tang G; Minemoto Y; Dibling B; Purcell N H; Li Z; Karin M; Lin A
Inhibition of JNK activation through NF-kappaB target genes.
Nature 2001;414(6861):313-7.
2001: Baud V; Karin M
Signal transduction by tumor necrosis factor and its relatives.
Trends in cell biology 2001;11(9):372-7.
2001: Yuan M; Konstantopoulos N; Lee J; Hansen L; Li Z W; Karin M; Shoelson S E
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta.
Science (New York, N.Y.) 2001;293(5535):1673-7.
2001: Senftleben U; Cao Y; Xiao G; Greten F R; Krähn G; Bonizzi G; Chen Y; Hu Y; Fong A; Sun S C; Karin M
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway.
Science (New York, N.Y.) 2001;293(5534):1495-9.
2001: Kim J K; Kim Y J; Fillmore J J; Chen Y; Moore I; Lee J; Yuan M; Li Z W; Karin M; Perret P; Shoelson S E; Shulman G I
Prevention of fat-induced insulin resistance by salicylate.
The Journal of clinical investigation 2001;108(3):437-46.
2001: Karin M; Shaulian E
AP-1: linking hydrogen peroxide and oxidative stress to the control of cell proliferation and death.
IUBMB life 2001;52(1-2):17-24.
2001: Han Z; Boyle D L; Chang L; Bennett B; Karin M; Yang L; Manning A M; Firestein G S
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.
The Journal of clinical investigation 2001;108(1):73-81.
2001: Jiménez B; Volpert O V; Reiher F; Chang L; Muñoz A; Karin M; Bouck N
c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1.
Oncogene 2001;20(26):3443-8.
2001: Karin M; Chang L
AP-1--glucocorticoid receptor crosstalk taken to a higher level.
The Journal of endocrinology 2001;169(3):447-51.
2001: Devin A; Lin Y; Yamaoka S; Li Z; Karin M; Liu Zg
The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF.
Molecular and cellular biology 2001;21(12):3986-94.
2001: Ojo-Amaize E A; Kapahi P; Kakkanaiah V N; Takahashi T; Shalom-Barak T; Cottam H B; Adesomoju A A; Nchekwube E J; Oyemade O A; Karin M; Okogun J I
Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase.
Cellular immunology 2001;209(2):149-57.
2001: Piu F; Aronheim A; Katz S; Karin M
AP-1 repressor protein JDP-2: inhibition of UV-mediated apoptosis through p53 down-regulation.
Molecular and cellular biology 2001;21(9):3012-24.
2001: Shaulian E; Karin M
AP-1 in cell proliferation and survival.
Oncogene 2001;20(19):2390-400.
2001: Arnaiz-Villena A; Karin M; Bendikuze N; Gomez-Casado E; Moscoso J; Silvera C; Oguz F S; Sarper Diler A; De Pacho A; Allende L; Guillen J; Martinez Laso J
HLA alleles and haplotypes in the Turkish population: relatedness to Kurds, Armenians and other Mediterraneans.
Tissue antigens 2001;57(4):308-17.
2001: Hu Y; Baud V; Oga T; Kim K I; Yoshida K; Karin M
IKKalpha controls formation of the epidermis independently of NF-kappaB.
Nature 2001;410(6829):710-4.
2001: Senftleben U; Li Z W; Baud V; Karin M
IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis.
Immunity 2001;14(3):217-30.
2001: Chang L; Karin M
Mammalian MAP kinase signalling cascades.
Nature 2001;410(6824):37-40.
2001: Li N; Banin S; Ouyang H; Li G C; Courtois G; Shiloh Y; Karin M; Rotman G
ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks.
The Journal of biological chemistry 2001;276(12):8898-903.
2001: Cavalli V; Vilbois F; Corti M; Marcote M J; Tamura K; Karin M; Arkinstall S; Gruenberg J
The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex.
Molecular cell 2001;7(2):421-32.
2001: Sabapathy K; Kallunki T; David J P; Graef I; Karin M; Wagner E F
c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation.
The Journal of experimental medicine 2001;193(3):317-28.
2001: Feng W; Webb P; Nguyen P; Liu X; Li J; Karin M; Kushner P J
Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway.
Molecular endocrinology (Baltimore, Md.) 2001;15(1):32-45.
2001: Karin M; Takahashi T; Kapahi P; Delhase M; Chen Y; Makris C; Rothwarf D; Baud V; Natoli G; Guido F; Li N
Oxidative stress and gene expression: the AP-1 and NF-kappaB connections.
BioFactors (Oxford, England) 2001;15(2-4):87-9.
2000: Chu W; Gong X; Li Z; Takabayashi K; Ouyang H; Chen Y; Lois A; Chen D J; Li G C; Karin M; Raz E
DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA.
Cell 2000;103(6):909-18.
2000: Shaulian E; Schreiber M; Piu F; Beeche M; Wagner E F; Karin M
The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest.
Cell 2000;103(6):897-907.
2000: Yoshida K; Hu Y; Karin M
IkappaB kinase alpha is essential for development of the mammalian cornea and conjunctiva.
Investigative ophthalmology & visual science 2000;41(12):3665-9.
2000: Kapahi P; Takahashi T; Natoli G; Adams S R; Chen Y; Tsien R Y; Karin M
Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase.
The Journal of biological chemistry 2000;275(46):36062-6.
2000: Tamura K; Sudo T; Senftleben U; Dadak A M; Johnson R; Karin M
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.
Cell 2000;102(2):221-31.
2000: Delhase M; Li N; Karin M
Kinase regulation in inflammatory response.
Nature 2000;406(6794):367-8.
2000: Spence J; Gali R R; Dittmar G; Sherman F; Karin M; Finley D
Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain.
Cell 2000;102(1):67-76.
2000: López-Fernández J; Palacios D; Castillo A I; Tolon R M; Aranda A; Karin M
Differentiation of lactotrope precursor GHFT cells in response to fibroblast growth factor-2.
The Journal of biological chemistry 2000;275(28):21653-60.
2000: Makris C; Godfrey V L; Krähn-Senftleben G; Takahashi T; Roberts J L; Schwarz T; Feng L; Johnson R S; Karin M
Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti.
Molecular cell 2000;5(6):969-79.
2000: Wu Z; Woodring P J; Bhakta K S; Tamura K; Wen F; Feramisco J R; Karin M; Wang J Y; Puri P L
p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps.
Molecular and cellular biology 2000;20(11):3951-64.
2000: Chen C Y; Gherzi R; Andersen J S; Gaietta G; Jürchott K; Royer H D; Mann M; Karin M
Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation.
Genes & development 2000;14(10):1236-48.
2000: Xia Y; Makris C; Su B; Li E; Yang J; Nemerow G R; Karin M
MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5243-8.
2000: Tojima Y; Fujimoto A; Delhase M; Chen Y; Hatakeyama S; Nakayama K; Kaneko Y; Nimura Y; Motoyama N; Ikeda K; Karin M; Nakanishi M
NAK is an IkappaB kinase-activating kinase.
Nature 2000;404(6779):778-82.
2000: Cheng J; Yang J; Xia Y; Karin M; Su B
Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation.
Molecular and cellular biology 2000;20(7):2334-42.
2000: Puri P L; Wu Z; Zhang P; Wood L D; Bhakta K S; Han J; Feramisco J R; Karin M; Wang J Y
Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells.
Genes & development 2000;14(5):574-84.
2000: Karin M; Delhase M
The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling.
Seminars in immunology 2000;12(1):85-98.
2000: Rossi A; Kapahi P; Natoli G; Takahashi T; Chen Y; Karin M; Santoro M G
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase.
Nature 2000;403(6765):103-8.
2000: Aronheim A; Karin M
Analysis and identification of protein-protein interactions using protein recruitment systems.
Methods in enzymology 2000;328():47-59.
2000: Sudo T; Karin M
Assays for JNK and p38 mitogen-activated protein kinases.
Methods in enzymology 2000;322():388-92.
2000: Li N; Karin M
Signaling pathways leading to nuclear factor-kappa B activation.
Methods in enzymology 2000;319():273-9.
2000: Karin M; Ben-Neriah Y
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
Annual review of immunology 2000;18():621-63.
1999: Chu W M; Ostertag D; Li Z W; Chang L; Chen Y; Hu Y; Williams B; Perrault J; Karin M
JNK2 and IKKbeta are required for activating the innate response to viral infection.
Immunity 1999;11(6):721-31.
1999: Sabapathy K; Jochum W; Hochedlinger K; Chang L; Karin M; Wagner E F
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2.
Mechanisms of development 1999;89(1-2):115-24.
1999: Karin M
How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex.
Oncogene 1999;18(49):6867-74.
1999: Rothwarf D M; Karin M
The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus.
Science's STKE : signal transduction knowledge environment 1999;1999(5):RE1.
1999: Shaulian E; Karin M
Stress-induced JNK activation is independent of Gadd45 induction.
The Journal of biological chemistry 1999;274(42):29595-8.
1999: Karin M
The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation.
The Journal of biological chemistry 1999;274(39):27339-42.
1999: Li N; Karin M
Is NF-kappaB the sensor of oxidative stress?
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(10):1137-43.
1999: Zandi E; Karin M
Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex.
Molecular and cellular biology 1999;19(7):4547-51.
1999: Li Z W; Chu W; Hu Y; Delhase M; Deerinck T; Ellisman M; Johnson R; Karin M
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.
The Journal of experimental medicine 1999;189(11):1839-45.
1999: Baud V; Liu Z G; Bennett B; Suzuki N; Xia Y; Karin M
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.
Genes & development 1999;13(10):1297-308.
1999: Tian J; Karin M
Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin).
The Journal of biological chemistry 1999;274(21):15173-80.
1999: Hu Y; Baud V; Delhase M; Zhang P; Deerinck T; Ellisman M; Johnson R; Karin M
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase.
Science (New York, N.Y.) 1999;284(5412):316-20.
1999: Delhase M; Hayakawa M; Chen Y; Karin M
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.
Science (New York, N.Y.) 1999;284(5412):309-13.
1999: Schreiber M; Kolbus A; Piu F; Szabowski A; Möhle-Steinlein U; Tian J; Karin M; Angel P; Wagner E F
Control of cell cycle progression by c-Jun is p53 dependent.
Genes & development 1999;13(5):607-19.
1999: Sabapathy K; Hu Y; Kallunki T; Schreiber M; David J P; Jochum W; Wagner E F; Karin M
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.
Current biology : CB 1999;9(3):116-25.
1999: Hettmann T; DiDonato J; Karin M; Leiden J M
An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis.
The Journal of experimental medicine 1999;189(1):145-58.
1999: Le-Niculescu H; Bonfoco E; Kasuya Y; Claret F X; Green D R; Karin M
Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death.
Molecular and cellular biology 1999;19(1):751-63.
1999: Delhase M; Karin M
The I kappa B kinase: a master regulator of NF-kappa B, innate immunity, and epidermal differentiation.
Cold Spring Harbor symposia on quantitative biology 1999;64():491-503.
1998: Xia Y; Wu Z; Su B; Murray B; Karin M
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.
Genes & development 1998;12(21):3369-81.
1998: Li N; Karin M
Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13012-7.
1998: Rothwarf D M; Zandi E; Natoli G; Karin M
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.
Nature 1998;395(6699):297-300.
1998: Zandi E; Chen Y; Karin M
Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate.
Science (New York, N.Y.) 1998;281(5381):1360-3.
1998: Uhlik M; Good L; Xiao G; Harhaj E W; Zandi E; Karin M; Sun S C
NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation.
The Journal of biological chemistry 1998;273(33):21132-6.
1998: Karin M; Delhase M
JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9067-9.
1998: Engelberg D; Mimran A; Martinetto H; Otto J; Simchen G; Karin M; Fink G R
Multicellular stalk-like structures in Saccharomyces cerevisiae.
Journal of bacteriology 1998;180(15):3992-6.
1998: Herdegen T; Claret F X; Kallunki T; Martin-Villalba A; Winter C; Hunter T; Karin M
Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(14):5124-35.
1998: Karin M
Mitogen-activated protein kinase cascades as regulators of stress responses.
Annals of the New York Academy of Sciences 1998;851():139-46.
1998: Chen C Y; Del Gatto-Konczak F; Wu Z; Karin M
Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway.
Science (New York, N.Y.) 1998;280(5371):1945-9.
1998: Galli T; Zahraoui A; Vaidyanathan V V; Raposo G; Tian J M; Karin M; Niemann H; Louvard D
A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells.
Molecular biology of the cell 1998;9(6):1437-48.
1998: Werlen G; Jacinto E; Xia Y; Karin M
Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes.
The EMBO journal 1998;17(11):3101-11.
1998: Karin M
The NF-kappa B activation pathway: its regulation and role in inflammation and cell survival.
The cancer journal from Scientific American 1998;4 Suppl 1():S92-9.
1998: Karin M
New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?
Cell 1998;93(4):487-90.
1998: Jacinto E; Werlen G; Karin M
Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes.
Immunity 1998;8(1):31-41.
1997: Wu Z; Wu J; Jacinto E; Karin M
Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase.
Molecular and cellular biology 1997;17(12):7407-16.
1997: Minden A; Karin M
Regulation and function of the JNK subgroup of MAP kinases.
Biochimica et biophysica acta 1997;1333(2):F85-104.
1997: Zandi E; Rothwarf D M; Delhase M; Hayakawa M; Karin M
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.
Cell 1997;91(2):243-52.
1997: DiDonato J A; Hayakawa M; Rothwarf D M; Zandi E; Karin M
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.
Nature 1997;388(6642):548-54.
1997: Saatcioglu F; Lopez G; West B L; Zandi E; Feng W; Lu H; Esmaili A; Apriletti J W; Kushner P J; Baxter J D; Karin M
Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity.
Molecular and cellular biology 1997;17(8):4687-95.
1997: Aronheim A; Zandi E; Hennemann H; Elledge S J; Karin M
Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.
Molecular and cellular biology 1997;17(6):3094-102.
1997: Barnes P J; Karin M
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.
The New England journal of medicine 1997;336(15):1066-71.
1997: Karin M; Liu Z g; Zandi E
AP-1 function and regulation.
Current opinion in cell biology 1997;9(2):240-6.
1997: Auphan N; Didonato J A; Helmberg A; Rosette C; Karin M
Immunoregulatory genes and immunosuppression by glucocorticoids.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1997;19():87-95.
1996: Reach M; Galindo R L; Towb P; Allen J L; Karin M; Wasserman S A
A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo.
Developmental biology 1996;180(1):353-64.
1996: Cavigelli M; Li W W; Lin A; Su B; Yoshioka K; Karin M
The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase.
The EMBO journal 1996;15(22):6269-79.
1996: Kallunki T; Deng T; Hibi M; Karin M
c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions.
Cell 1996;87(5):929-39.
1996: Liu Z G; Baskaran R; Lea-Chou E T; Wood L D; Chen Y; Karin M; Wang J Y
Three distinct signalling responses by murine fibroblasts to genotoxic stress.
Nature 1996;384(6606):273-6.
1996: Liu Z G; Hsu H; Goeddel D V; Karin M
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death.
Cell 1996;87(3):565-76.
1996: Rosette C; Karin M
Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors.
Science (New York, N.Y.) 1996;274(5290):1194-7.
1996: Li Y S; Shyy J Y; Li S; Lee J; Su B; Karin M; Chien S
The Ras-JNK pathway is involved in shear-induced gene expression.
Molecular and cellular biology 1996;16(11):5947-54.
1996: Claret F X; Hibi M; Dhut S; Toda T; Karin M
A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.
Nature 1996;383(6599):453-7.
1996: Didonato J A; Saatcioglu F; Karin M
Molecular mechanisms of immunosuppression and anti-inflammatory activities by glucocorticoids.
American journal of respiratory and critical care medicine 1996;154(2 Pt 2):S11-5.
1996: Collins L R; Minden A; Karin M; Brown J H
Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac.
The Journal of biological chemistry 1996;271(29):17349-53.
1996: Su B; Karin M
Mitogen-activated protein kinase cascades and regulation of gene expression.
Current opinion in immunology 1996;8(3):402-11.
1996: DiDonato J; Mercurio F; Rosette C; Wu-Li J; Suyang H; Ghosh S; Karin M
Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation.
Molecular and cellular biology 1996;16(4):1295-304.
1996: Karin M
The regulation of AP-1 activity by mitogen-activated protein kinases.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1336):127-34.
1996: Johnson N L; Gardner A M; Diener K M; Lange-Carter C A; Gleavy J; Jarpe M B; Minden A; Karin M; Zon L I; Johnson G L
Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death.
The Journal of biological chemistry 1996;271(6):3229-37.
1996: Claret F X; Antakly T; Karin M; Saatcioglu F
A shift in the ligand responsiveness of thyroid hormone receptor alpha induced by heterodimerization with retinoid X receptor alpha.
Molecular and cellular biology 1996;16(1):219-27.
1995: Cavigelli M; Dolfi F; Claret F X; Karin M
Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.
The EMBO journal 1995;14(23):5957-64.
1995: Caelles C; Hennemann H; Karin M
M-phase-specific phosphorylation of the POU transcription factor GHF-1 by a cell cycle-regulated protein kinase inhibits DNA binding.
Molecular and cellular biology 1995;15(12):6694-701.
1995: Auphan N; DiDonato J A; Rosette C; Helmberg A; Karin M
Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis.
Science (New York, N.Y.) 1995;270(5234):286-90.
1995: Karin M
The regulation of AP-1 activity by mitogen-activated protein kinases.
The Journal of biological chemistry 1995;270(28):16483-6.
1995: Karin M; Hunter T
Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus.
Current biology : CB 1995;5(7):747-57.
1995: Minden A; Lin A; Claret F X; Abo A; Karin M
Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs.
Cell 1995;81(7):1147-57.
1995: Yoshioka K; Deng T; Cavigelli M; Karin M
Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):4972-6.
1995: Lin A; Minden A; Martinetto H; Claret F X; Lange-Carter C; Mercurio F; Johnson G L; Karin M
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.
Science (New York, N.Y.) 1995;268(5208):286-90.
1995: Rosette C; Karin M
Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B.
The Journal of cell biology 1995;128(6):1111-9.
1995: DiDonato J A; Mercurio F; Karin M
Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B.
Molecular and cellular biology 1995;15(3):1302-11.
1995: White M A; Nicolette C; Minden A; Polverino A; Van Aelst L; Karin M; Wigler M H
Multiple Ras functions can contribute to mammalian cell transformation.
Cell 1995;80(4):533-41.
1995: Helmberg A; Auphan N; Caelles C; Karin M
Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor.
The EMBO journal 1995;14(3):452-60.
1994: Kallunki T; Su B; Tsigelny I; Sluss H K; Dérijard B; Moore G; Davis R; Karin M
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.
Genes & development 1994;8(24):2996-3007.
1994: Minden A; Lin A; McMahon M; Lange-Carter C; Dérijard B; Davis R J; Johnson G L; Karin M
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK.
Science (New York, N.Y.) 1994;266(5191):1719-23.
1994: Smeal T; Hibi M; Karin M
Altering the specificity of signal transduction cascades: positive regulation of c-Jun transcriptional activity by protein kinase A.
The EMBO journal 1994;13(24):6006-10.
1994: Minden A; Lin A; Smeal T; Dérijard B; Cobb M; Davis R; Karin M
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.
Molecular and cellular biology 1994;14(10):6683-8.
1994: Westwick J K; Weitzel C; Minden A; Karin M; Brenner D A
Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase.
The Journal of biological chemistry 1994;269(42):26396-401.
1994: Saatcioglu F; Claret F X; Karin M
Negative transcriptional regulation by nuclear receptors.
Seminars in cancer biology 1994;5(5):347-59.
1994: Deng T; Karin M
c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK.
Nature 1994;371(6493):171-5.
1994: Aronheim A; Engelberg D; Li N; al-Alawi N; Schlessinger J; Karin M
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.
Cell 1994;78(6):949-61.
1994: Arias J; Alberts A S; Brindle P; Claret F X; Smeal T; Karin M; Feramisco J; Montminy M
Activation of cAMP and mitogen responsive genes relies on a common nuclear factor.
Nature 1994;370(6486):226-9.
1994: Caelles C; Helmberg A; Karin M
p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes.
Nature 1994;370(6486):220-3.
1994: Engelberg D; Zandi E; Parker C S; Karin M
The yeast and mammalian Ras pathways control transcription of heat shock genes independently of heat shock transcription factor.
Molecular and cellular biology 1994;14(7):4929-37.
1994: Inouye C; Remondelli P; Karin M; Elledge S
Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system.
DNA and cell biology 1994;13(7):731-42.
1994: Su B; Jacinto E; Hibi M; Kallunki T; Karin M; Ben-Neriah Y
JNK is involved in signal integration during costimulation of T lymphocytes.
Cell 1994;77(5):727-36.
1994: Trautwein C; van der Geer P; Karin M; Hunter T; Chojkier M
Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements.
The Journal of clinical investigation 1994;93(6):2554-61.
1994: Zhang Q; Didonato J A; Karin M; McKeithan T W
BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins.
Molecular and cellular biology 1994;14(6):3915-26.
1994: Westwick J K; Cox A D; Der C J; Cobb M H; Hibi M; Karin M; Brenner D A
Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6030-4.
1994: Karin M
Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors.
Current opinion in cell biology 1994;6(3):415-24.
1994: Engelberg D; Klein C; Martinetto H; Struhl K; Karin M
The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals.
Cell 1994;77(3):381-90.
1994: Dérijard B; Hibi M; Wu I H; Barrett T; Su B; Deng T; Karin M; Davis R J
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.
Cell 1994;76(6):1025-37.
1993: Theill L E; Karin M
Transcriptional control of GH expression and anterior pituitary development.
Endocrine reviews 1993;14(6):670-89.
1993: Saatcioglu F; Deng T; Karin M
A novel cis element mediating ligand-independent activation by c-ErbA: implications for hormonal regulation.
Cell 1993;75(6):1095-105.
1993: Hibi M; Lin A; Smeal T; Minden A; Karin M
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
Genes & development 1993;7(11):2135-48.
1993: Devary Y; Rosette C; DiDonato J A; Karin M
NF-kappa B activation by ultraviolet light not dependent on a nuclear signal.
Science (New York, N.Y.) 1993;261(5127):1442-5.
1993: Trautwein C; Caelles C; van der Geer P; Hunter T; Karin M; Chojkier M
Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain.
Nature 1993;364(6437):544-7.
1993: Saatcioglu F; Bartunek P; Deng T; Zenke M; Karin M
A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor).
Molecular and cellular biology 1993;13(6):3675-85.
1993: Mercurio F; DiDonato J A; Rosette C; Karin M
p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.
Genes & development 1993;7(4):705-18.
1993: Alberts A S; Deng T; Lin A; Meinkoth J L; Schönthal A; Mumby M C; Karin M; Feramisco J R
Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements.
Molecular and cellular biology 1993;13(4):2104-12.
1993: Lew D; Brady H; Klausing K; Yaginuma K; Theill L E; Stauber C; Karin M; Mellon P L
GHF-1-promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice.
Genes & development 1993;7(4):683-93.
1993: Deng T; Karin M
JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers.
Genes & development 1993;7(3):479-90.
1993: Hattori M; Tugores A; Westwick J K; Veloz L; Leffert H L; Karin M; Brenner D A
Activation of activating protein 1 during hepatic acute phase response.
The American journal of physiology 1993;264(1 Pt 1):G95-103.
1993: Ekström T J; Klump W M; Getman D; Karin M; Taylor P
Promoter elements and transcriptional regulation of the acetylcholinesterase gene.
DNA and cell biology 1993;12(1):63-72.
1993: Skroch P; Buchman C; Karin M
Regulation of human and yeast metallothionein gene transcription by heavy metal ions.
Progress in clinical and biological research 1993;380():113-28.
1993: Lin A; Smeal T; Binetruy B; Deng T; Chambard J C; Karin M
Control of AP-1 activity by signal transduction cascades.
Advances in second messenger and phosphoprotein research 1993;28():255-60.
1993: Karin M; Yang-Yen H F; Chambard J C; Deng T; Saatcioglu F
Various modes of gene regulation by nuclear receptors for steroid and thyroid hormones.
European journal of clinical pharmacology 1993;45 Suppl 1():S9-15; discussion S43-4.
1992: Devary Y; Gottlieb R A; Smeal T; Karin M
The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases.
Cell 1992;71(7):1081-91.
1992: Karin M; Smeal T
Control of transcription factors by signal transduction pathways: the beginning of the end.
Trends in biochemical sciences 1992;17(10):418-22.
1992: Trejo J; Chambard J C; Karin M; Brown J H
Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation.
Molecular and cellular biology 1992;12(10):4742-50.
1992: Deng T; Karin M
Construction and expression of a monomeric c-Jun protein that binds and activates transcription of AP-1-responsive genes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8572-6.
1992: Lin A; Frost J; Deng T; Smeal T; al-Alawi N; Kikkawa U; Hunter T; Brenner D; Karin M
Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity.
Cell 1992;70(5):777-89.
1992: Mercurio F; Didonato J; Rosette C; Karin M
Molecular cloning and characterization of a novel Rel/NF-kappa B family member displaying structural and functional homology to NF-kappa B p50/p105.
DNA and cell biology 1992;11(7):523-37.
1992: Hunter T; Karin M
The regulation of transcription by phosphorylation.
Cell 1992;70(3):375-87.
1992: Smeal T; Binetruy B; Mercola D; Grover-Bardwick A; Heidecker G; Rapp U R; Karin M
Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.
Molecular and cellular biology 1992;12(8):3507-13.
1992: Hagiwara M; Alberts A; Brindle P; Meinkoth J; Feramisco J; Deng T; Karin M; Shenolikar S; Montminy M
Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB.
Cell 1992;70(1):105-13.
1992: Theill L E; Hattori K; Lazzaro D; Castrillo J L; Karin M
Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins.
The EMBO journal 1992;11(6):2261-9.
1992: Karin M
Signal transduction from cell surface to nucleus in development and disease.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(8):2581-90.
1992: Li L; Chambard J C; Karin M; Olson E N
Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression.
Genes & development 1992;6(4):676-89.
1992: Angel P; Karin M
Specific members of the Jun protein family regulate collagenase expression in response to various extracellular stimuli.
Matrix (Stuttgart, Germany). Supplement 1992;1():156-64.
1991: Alani R; Brown P; Binétruy B; Dosaka H; Rosenberg R K; Angel P; Karin M; Birrer M J
The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells.
Molecular and cellular biology 1991;11(12):6286-95.
1991: Angel P; Karin M
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Biochimica et biophysica acta 1991;1072(2-3):129-57.
1991: Smeal T; Binetruy B; Mercola D A; Birrer M; Karin M
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73.
Nature 1991;354(6353):494-6.
1991: Yang-Yen H F; Zhang X K; Graupner G; Tzukerman M; Sakamoto B; Karin M; Pfahl M
Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation.
The New biologist 1991;3(12):1206-19.
1991: McCormick A; Brady H; Fukushima J; Karin M
The pituitary-specific regulatory gene GHF1 contains a minimal cell type-specific promoter centered around its TATA box.
Genes & development 1991;5(8):1490-503.
1991: Castrillo J L; Theill L E; Karin M
Function of the homeodomain protein GHF1 in pituitary cell proliferation.
Science (New York, N.Y.) 1991;253(5016):197-9.
1991: Karin M
Signal transduction and gene control.
Current opinion in cell biology 1991;3(3):467-73.
1991: Binétruy B; Smeal T; Karin M
Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain.
Nature 1991;351(6322):122-7.
1991: Devary Y; Gottlieb R A; Lau L F; Karin M
Rapid and preferential activation of the c-jun gene during the mammalian UV response.
Molecular and cellular biology 1991;11(5):2804-11.
1991: Boyle W J; Smeal T; Defize L H; Angel P; Woodgett J R; Karin M; Hunter T
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.
Cell 1991;64(3):573-84.
1990: Karin M; Theill L; Castrillo J L; McCormick A; Brady H
Cell type specific expression of the growth hormone gene and its control by GHF-1.
Nippon Naibunpi Gakkai zasshi 1990;66(12):1205-20.
1990: Hattori M; Tugores A; Veloz L; Karin M; Brenner D A
A simplified method for the preparation of transcriptionally active liver nuclear extracts.
DNA and cell biology 1990;9(10):777-81.
1990: Karin M
Transcriptional control and the integration of cell-autonomous and environmental cues during development.
Current opinion in cell biology 1990;2(6):996-1002.
1990: West A K; Stallings R; Hildebrand C E; Chiu R; Karin M; Richards R I
Human metallothionein genes: structure of the functional locus at 16q13.
Genomics 1990;8(3):513-8.
1990: William F; Wagner F; Karin M; Kraft A S
Multiple doses of diacylglycerol and calcium ionophore are necessary to activate AP-1 enhancer activity and induce markers of macrophage differentiation.
The Journal of biological chemistry 1990;265(30):18166-71.
1990: Yang-Yen H F; Chambard J C; Sun Y L; Smeal T; Schmidt T J; Drouin J; Karin M
Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction.
Cell 1990;62(6):1205-15.
1990: Buchman C; Skroch P; Dixon W; Tullius T D; Karin M
A single amino acid change in CUP2 alters its mode of DNA binding.
Molecular and cellular biology 1990;10(9):4778-87.
1990: Lafyatis R; Kim S J; Angel P; Roberts A B; Sporn M B; Karin M; Wilder R L
Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5' activator protein-1-binding site.
Molecular endocrinology (Baltimore, Md.) 1990;4(7):973-80.
1990: Radler-Pohl A; Pfeuffer I; Karin M; Serfling E
A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter.
The New biologist 1990;2(6):566-73.
1990: McCormick A; Brady H; Theill L E; Karin M
Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues.
Nature 1990;345(6278):829-32.
1990: Kaina B; Lohrer H; Karin M; Herrlich P
Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2710-4.
1990: Allegretto E A; Smeal T; Angel P; Spiegelman B M; Karin M
DNA-binding activity of Jun is increased through its interaction with Fos.
Journal of cellular biochemistry 1990;42(4):193-206.
1990: Kim S J; Angel P; Lafyatis R; Hattori K; Kim K Y; Sporn M B; Karin M; Roberts A B
Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.
Molecular and cellular biology 1990;10(4):1492-7.
1990: Yang-Yen H F; Chiu R; Karin M
Elevation of AP1 activity during F9 cell differentiation is due to increased c-jun transcription.
The New biologist 1990;2(4):351-61.
1990: Karin M; Castrillo J L; Theill L E
Growth hormone gene regulation: a paradigm for cell-type-specific gene activation.
Trends in genetics : TIG 1990;6(3):92-6.
1990: Dollé P; Castrillo J L; Theill L E; Deerinck T; Ellisman M; Karin M
Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity.
Cell 1990;60(5):809-20.
1990: Karin M
Too many transcription factors: positive and negative interactions.
The New biologist 1990;2(2):126-31.
1990: Kim S J; Lafyatis R; Kim K Y; Angel P; Fujiki H; Karin M; Sporn M B; Roberts A B
Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases.
Cell regulation 1990;1(3):269-78.
1990: Karin M; Theill L; Castrillo J L; McCormick A; Brady H
Tissue-specific expression of the growth hormone gene and its control by growth hormone factor-1.
Recent progress in hormone research 1990;46():43-57; discussion 57-8.
1990: Leffert H L; Koch K S; Lu X P; Brenner D A; Karin M; Skelly H F; Rippe R A; Fey G; Chojkier M
Cellular and molecular biology of hepatocyte growth, regeneration and gene expression.
Advances in second messenger and phosphoprotein research 1990;24():352-8.
1989: Theill L E; Castrillo J L; Wu D; Karin M
Dissection of functional domains of the pituitary-specific transcription factor GHF-1.
Nature 1989;342(6252):945-8.
1989: Smeal T; Angel P; Meek J; Karin M
Different requirements for formation of Jun: Jun and Jun: Fos complexes.
Genes & development 1989;3(12B):2091-100.
1989: Chiu R; Angel P; Karin M
Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun.
Cell 1989;59(6):979-86.
1989: Muegge K; Williams T M; Kant J; Karin M; Chiu R; Schmidt A; Siebenlist U; Young H A; Durum S K
Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1.
Science (New York, N.Y.) 1989;246(4927):249-51.
1989: Angel P; Smeal T; Meek J; Karin M
Jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner.
The New biologist 1989;1(1):35-43.
1989: Buchman C; Skroch P; Welch J; Fogel S; Karin M
The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein.
Molecular and cellular biology 1989;9(9):4091-5.
1989: Mercurio F; Karin M
Transcription factors AP-3 and AP-2 interact with the SV40 enhancer in a mutually exclusive manner.
The EMBO journal 1989;8(5):1455-60.
1989: Dana S; Karin M
Induction of human growth hormone promoter activity by the adenosine 3',5'-monophosphate pathway involves a novel responsive element.
Molecular endocrinology (Baltimore, Md.) 1989;3(5):815-21.
1989: Schönthal A; Büscher M; Angel P; Rahmsdorf H J; Ponta H; Hattori K; Chiu R; Karin M; Herrlich P
The Fos and Jun/AP-1 proteins are involved in the downregulation of Fos transcription.
Oncogene 1989;4(5):629-36.
1989: Karin M
Complexities of gene regulation by cAMP.
Trends in genetics : TIG 1989;5(3):65-7.
1989: Castrillo J L; Bodner M; Karin M
Purification of growth hormone-specific transcription factor GHF-1 containing homeobox.
Science (New York, N.Y.) 1989;243(4892):814-7.
1989: Serfling E; Barthelmäs R; Pfeuffer I; Schenk B; Zarius S; Swoboda R; Mercurio F; Karin M
Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes.
The EMBO journal 1989;8(2):465-73.
1989: Brenner D A; O'Hara M; Angel P; Chojkier M; Karin M
Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha.
Nature 1989;337(6208):661-3.
1989: Welch J; Fogel S; Buchman C; Karin M
The CUP2 gene product regulates the expression of the CUP1 gene, coding for yeast metallothionein.
The EMBO journal 1989;8(1):255-60.
1988: Hattori K; Angel P; Le Beau M M; Karin M
Structure and chromosomal localization of the functional intronless human JUN protooncogene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9148-52.
1988: Angel P; Hattori K; Smeal T; Karin M
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1.
Cell 1988;55(5):875-85.
1988: Haugen T H; Turek L P; Mercurio F M; Cripe T P; Olson B J; Anderson R D; Seidl D; Karin M; Schiller J
Sequence-specific and general transcriptional activation by the bovine papillomavirus-1 E2 trans-activator require an N-terminal amphipathic helix-containing E2 domain.
The EMBO journal 1988;7(13):4245-53.
1988: Bodner M; Castrillo J L; Theill L E; Deerinck T; Ellisman M; Karin M
The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein.
Cell 1988;55(3):505-18.
1988: McCormick A; Wu D; Castrillo J L; Dana S; Strobl J; Thompson E B; Karin M
Extinction of growth hormone expression in somatic cell hybrids involves repression of the specific trans-activator GHF-1.
Cell 1988;55(2):379-89.
1988: Hai T W; Liu F; Allegretto E A; Karin M; Green M R
A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1.
Genes & development 1988;2(10):1216-26.
1988: Büscher M; Rahmsdorf H J; Litfin M; Karin M; Herrlich P
Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element.
Oncogene 1988;3(3):301-11.
1988: Chiu R; Boyle W J; Meek J; Smeal T; Hunter T; Karin M
The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes.
Cell 1988;54(4):541-52.
1988: Slater E P; Cato A C; Karin M; Baxter J D; Beato M
Progesterone induction of metallothionein-IIA gene expression.
Molecular endocrinology (Baltimore, Md.) 1988;2(6):485-91.
1988: Harrington M A; Jones P A; Imagawa M; Karin M
Cytosine methylation does not affect binding of transcription factor Sp1.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(7):2066-70.
1988: Angel P; Allegretto E A; Okino S T; Hattori K; Boyle W J; Hunter T; Karin M
Oncogene jun encodes a sequence-specific trans-activator similar to AP-1.
Nature 1988;332(6160):166-71.
1988: Hunter T; Angel P; Boyle W J; Chiu R; Freed E; Gould K L; Isacke C M; Karin M; Lindberg R A; van der Geer P
Targets for signal-transducing protein kinases.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():131-42.
1987: Dinter H; Chiu R; Imagawa M; Karin M; Jones K A
In vitro activation of the HIV-1 enhancer in extracts from cells treated with a phorbol ester tumor promoter.
The EMBO journal 1987;6(13):4067-71.
1987: Imagawa M; Chiu R; Karin M
Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP.
Cell 1987;51(2):251-60.
1987: Chiu R; Imagawa M; Imbra R J; Bockoven J R; Karin M
Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters.
Nature 1987;329(6140):648-51.
1987: Bodner M; Karin M
A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells.
Cell 1987;50(2):267-75.
1987: Angel P; Imagawa M; Chiu R; Stein B; Imbra R J; Rahmsdorf H J; Jonat C; Herrlich P; Karin M
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor.
Cell 1987;49(6):729-39.
1987: Packman S; Palmiter R D; Karin M; O'Toole C
Metallothionein messenger RNA regulation in the mottled mouse and Menkes kinky hair syndrome.
The Journal of clinical investigation 1987;79(5):1338-42.
1987: Imbra R J; Karin M
Metallothionein gene expression is regulated by serum factors and activators of protein kinase C.
Molecular and cellular biology 1987;7(4):1358-63.
1987: Lefevre C; Imagawa M; Dana S; Grindlay J; Bodner M; Karin M
Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.
The EMBO journal 1987;6(4):971-81.
1987: Karin M; Haslinger A; Heguy A; Dietlin T; Cooke T
Metal-responsive elements act as positive modulators of human metallothionein-IIA enhancer activity.
Molecular and cellular biology 1987;7(2):606-13.
1987: Haugen T H; Cripe T P; Ginder G D; Karin M; Turek L P
Trans-activation of an upstream early gene promoter of bovine papilloma virus-1 by a product of the viral E2 gene.
The EMBO journal 1987;6(1):145-52.
1987: Lee W; Haslinger A; Karin M; Tjian R
Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40.
Nature 1987;325(6102):368-72.
1987: Karin M; Haslinger A; Heguy A; Dietlin T; Imbra R
Transcriptional control mechanisms which regulate the expression of human metallothionein genes.
Experientia. Supplementum 1987;52():401-5.
1986: Imbra R J; Karin M
Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer.
Nature 1986;323(6088):555-8.
1986: Heguy A; West A; Richards R I; Karin M
Structure and tissue-specific expression of the human metallothionein IB gene.
Molecular and cellular biology 1986;6(6):2149-57.
1986: Scholer H; Haslinger A; Heguy A; Holtgreve H; Karin M
In vivo competition between a metallothionein regulatory element and the SV40 enhancer.
Science (New York, N.Y.) 1986;232(4746):76-80.
1985: Haslinger A; Karin M
Upstream promoter element of the human metallothionein-IIA gene can act like an enhancer element.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(24):8572-6.
1985: Slater E P; Rabenau O; Karin M; Baxter J D; Beato M
Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene.
Molecular and cellular biology 1985;5(11):2984-92.
1985: Karin M; Imbra R J; Heguy A; Wong G
Interleukin 1 regulates human metallothionein gene expression.
Molecular and cellular biology 1985;5(10):2866-9.
1985: Karin M
Metallothioneins: proteins in search of function.
Cell 1985;41(1):9-10.
1985: Le Beau M M; Diaz M O; Karin M; Rowley J D
Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia.
Nature 1985;313(6004):709-11.
1985: Slater E P; Anderson T R; Cattini P A; Eberhardt N L; Karin M; Mellon P L; Baxter J D
Tissue-specific influences affect glucocorticoid regulatory element actions on the human growth hormone gene promotor.
Transactions of the Association of American Physicians 1985;98():66-73.
1984: Karin M; Eddy R L; Henry W M; Haley L L; Byers M G; Shows T B
Human metallothionein genes are clustered on chromosome 16.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(17):5494-8.
1984: Karin M; Holtgreve H
Nucleotide sequence requirements for transient expression of human metallothionein-IIA-thymidine kinase fusion genes.
DNA (Mary Ann Liebert, Inc.) 1984;3(4):319-26.
1984: Richards R I; Heguy A; Karin M
Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids.
Cell 1984;37(1):263-72.
1984: Karin M; Haslinger A; Holtgreve H; Richards R I; Krauter P; Westphal H M; Beato M
Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene.
Nature 1984;308(5959):513-9.
1984: Karin M; Richards R I
The human metallothionein gene family: structure and expression.
Environmental health perspectives 1984;54():111-5.
1984: Karin M; Haslinger A; Holtgreve H; Cathala G; Slater E; Baxter J D
Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5'-flanking DNA.
Cell 1984;36(2):371-9.
1984: Lan N C; Karin M; Nguyen T; Weisz A; Birnbaum M J; Eberhardt N L; Baxter J D
Mechanisms of glucocorticoid hormone action.
Journal of steroid biochemistry 1984;20(1):77-88.
1984: Karin M; Najarian R; Haslinger A; Valenzuela P; Welch J; Fogel S
Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(2):337-41.
1984: Karin M; Eberhardt N L; Mellon S H; Malich N; Richards R I; Slater E P; Barta A; Martial J A; Baxter J D; Cathala G
Expression and hormonal regulation of the rat growth hormone gene in transfected mouse L cells.
DNA (Mary Ann Liebert, Inc.) 1984;3(2):147-55.
1983: Welch J W; Fogel S; Cathala G; Karin M
Industrial yeasts display tandem gene iteration at the CUP1 region.
Molecular and cellular biology 1983;3(8):1353-61.
1983: Karin M; Cathala G; Nguyen-Huu M C
Expression and regulation of a human metallothionein gene carried on an autonomously replicating shuttle vector.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(13):4040-4.
1983: Cathala G; Savouret J F; Mendez B; West B L; Karin M; Martial J A; Baxter J D
A method for isolation of intact, translationally active ribonucleic acid.
DNA (Mary Ann Liebert, Inc.) 1983;2(4):329-35.
1982: Karin M; Richards R I
Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene.
Nature 1982;299(5886):797-802.
1982: Karin M; Richards R I
Human metallothionein genes: molecular cloning and sequence analysis of the mRNA.
Nucleic acids research 1982;10(10):3165-73.
1981: Karin M; Andersen R D; Herschman H R
Induction of metallothionein mRNA in HeLa cells by dexamethasone and by heavy metals.
European journal of biochemistry / FEBS 1981;118(3):527-31.
1981: Karin M; Mintz B
Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells.
The Journal of biological chemistry 1981;256(7):3245-52.
1981: Karin M; Herschman H R
Induction of metallothionein in HeLa cells by dexamethasone and zinc.
European journal of biochemistry / FEBS 1981;113(2):267-72.
1981: Karin M; Slater E P; Herschman H R
Regulation of metallothionein synthesis in HeLa cells by heavy metals and glucocorticoids.
Journal of cellular physiology 1981;106(1):63-74.
1980: Karin M; Andersen R D; Slater E; Smith K; Herschman H R
Metallothionein mRNA induction in HeLa cells in response to zinc or dexamethasone is a primary induction response.
Nature 1980;286(5770):295-7.
1980: Karin M; Herschman H R
Characterization of the metallothioneins induced in HeLa cells by dexamethasone and zinc.
European journal of biochemistry / FEBS 1980;107(2):395-401.
1980: Karin M; Herschman H R
Glucocorticoid hormone receptor mediated induction of metallothionein synthesis in HeLa cells.
Journal of cellular physiology 1980;103(1):35-40.
1980: Karin M; Herschman H R; Weinstein D
Primary induction of metallothionein by dexamethasone in culture rat hepatocytes.
Biochemical and biophysical research communications 1980;92(3):1052-69.
1979: Karin M; Herschman H R
Dexamethasone stimulation of metallothionein synthesis in HeLa cell cultures.
Science (New York, N.Y.) 1979;204(4389):176-7.

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