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Christoph Karle

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Chemicals & Drugs

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Long QT Syndrome

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Martin Kulzer; Daniel Scherer; Eberhard P Scholz; Claudia Seyler; Dierk Thomas; Florian Welke; Panagiotis Xynogalos; Rüdiger Becker; Christoph A Karle; Hugo A Katus; Edgar Zitron
Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A.
Claudia Seyler; Ruediger Becker; E Duthil-Straub; J Gierten; Edgar Zitron; R H A Fink; Christoph A Karle; H A Katus; Eberhard P Scholz; Dierk Thomas
TASK1 (K(2P)3.1) K(+) channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation.
Eberhard P Scholz; Claudia Seyler; Dierk Thomas; M Völkers; F Welke; W Zhang; Ramona Bloehs; N Joss; Christoph A Karle; Hugo A Katus; Daniel Scherer; Edgar Zitron
Central role of PKCα in isoenzyme-selective regulation of cardiac transient outward current Ito and Kv4.3 channels.

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All Publications

2012: Martin Kulzer; Daniel Scherer; Eberhard P Scholz; Claudia Seyler; Dierk Thomas; Florian Welke; Panagiotis Xynogalos; Rüdiger Becker; Christoph A Karle; Hugo A Katus; Edgar Zitron
Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A.
Biochemical and biophysical research communications 2012;424(2):315-20.
2012: Claudia Seyler; Ruediger Becker; E Duthil-Straub; J Gierten; Edgar Zitron; R H A Fink; Christoph A Karle; H A Katus; Eberhard P Scholz; Dierk Thomas
TASK1 (K(2P)3.1) K(+) channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation.
British journal of pharmacology 2012;165(5):1467-75.
2011: Eberhard P Scholz; Claudia Seyler; Dierk Thomas; M Völkers; F Welke; W Zhang; Ramona Bloehs; N Joss; Christoph A Karle; Hugo A Katus; Daniel Scherer; Edgar Zitron
Central role of PKCα in isoenzyme-selective regulation of cardiac transient outward current Ito and Kv4.3 channels.
Journal of molecular and cellular cardiology 2011;51(5):722-9.
2011: Benjamin Meder; Eberhard P Scholz; David Hassel; Christoph Wolff; Steffen Just; Ina M Berger; Eva Patzel; Christoph A Karle; Hugo A Katus; Wolfgang Rottbauer
Reconstitution of defective protein trafficking rescues Long-QT syndrome in zebrafish.
Biochemical and biophysical research communications 2011;408(2):218-24.
2010: Eberhard P Scholz; Edgar Zitron; Hugo A Katus; Christoph A Karle
Cardiovascular ion channels as a molecular target of flavonoids.
Cardiovascular therapeutics 2010;28(4):e46-52.
2010: Sabrina Obers; Ingo Staudacher; Eckhard Ficker; Adrienne Dennis; Ronald Koschny; Hande Erdal; Ramona Bloehs; Jana Kisselbach; Christoph A Karle; Patrick A Schweizer; Hugo A Katus; Dierk Thomas
Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine.
Naunyn-Schmiedeberg's archives of pharmacology 2010;381(5):385-400.
2010: Jakob Gierten; Eckhard Ficker; Ramona Bloehs; Patrick A Schweizer; Edgar Zitron; Eberhard P Scholz; Christoph A Karle; Hugo A Katus; Dierk Thomas
The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone.
Naunyn-Schmiedeberg's archives of pharmacology 2010;381(3):261-70.
2010: Dierk Thomas; Markus Khalil; Markus Alter; Patrick A Schweizer; Christoph A Karle; Anna-Britt Wimmer; Manuela Licka; Hugo A Katus; Michael Koenen; Herbert E Ulmer; Joerg Zehelein
Biophysical characterization of KCNQ1 P320 mutations linked to long QT syndrome 1.
Journal of molecular and cellular cardiology 2010;48(1):230-7.
2009: Eberhard P Scholz; Nora Niemer; David Hassel; Edgar Zitron; Heinrich F Bürgers; Ramona Bloehs; Claudia Seyler; Daniel Scherer; Dierk Thomas; Sven Kathöfer; Hugo A Katus; Wolfgang A Rottbauer; Christoph A Karle
Biophysical properties of zebrafish ether-à-go-go related gene potassium channels.
Biochemical and biophysical research communications 2009;381(2):159-64.
2009: Daniel Scherer; David Hassel; Ramona Bloehs; Edgar Zitron; Katharina von Löwenstern; Claudia Seyler; Dierk Thomas; Franziska Konrad; Heiner F Bürgers; Gunnar Seemann; Wolfgang Rottbauer; Hugo A Katus; Christoph A Karle; Eberhard P Scholz
Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents.
British journal of pharmacology 2009;156(2):226-36.
2008: Wei Zhang; Edgar Zitron; Ramona Bloehs; Sandra Müller-Krebs; Eberhard P Scholz; Martin Zeier; Hugo Katus; Christoph A Karle; Vedat Schwenger
Dual regulation of renal Kir7.1 potassium channels by protein Kinase A and protein Kinase C.
Biochemical and biophysical research communications 2008;377(3):981-6.
2008: J Gierten; Eckhard Ficker; Ramona Bloehs; K Schlömer; Sven Kathöfer; Eberhard P Scholz; Edgar Zitron; Claudia Seyler; Alexander Bauer; Ruediger Becker; Hugo A Katus; Christoph A Karle; Dierk Thomas
Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.
British journal of pharmacology 2008;154(8):1680-90.
2008: Daniel Scherer; Katharina von Löwenstern; Edgar Zitron; Eberhard P Scholz; Ramona Bloehs; Sven Kathöfer; Dierk Thomas; Alexander Bauer; Hugo A Katus; Christoph A Karle; Claudia Seyler
Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin.
Naunyn-Schmiedeberg's archives of pharmacology 2008;378(1):73-83.
2008: David Hassel; Eberhard P Scholz; Nicole Trano; Oliver Friedrich; Steffen Just; Benjamin Meder; Daniel L Weiss; Edgar Zitron; Sabine Marquart; Britta Vogel; Christoph A Karle; Gunnar Seemann; Mark C Fishman; Hugo A Katus; Wolfgang Rottbauer
Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants.
Circulation 2008;117(7):866-75.
2008: Dierk Thomas; Ramona Bloehs; Ronald Koschny; Eckhard Ficker; Jaromir Sykora; Johann Kiehn; Kathrin Schlömer; Jakob Gierten; Sven Kathöfer; Edgar Zitron; Eberhard P Scholz; Claudia Seyler; Hugo A Katus; Christoph A Karle
Doxazosin induces apoptosis of cells expressing hERG K+ channels.
European journal of pharmacology 2008;579(1-3):98-103.
2008: Edgar Zitron; Myriam Günth; Daniel Scherer; Claudia Seyler; Martin Kulzer; Ramona Bloehs; Eberhard P Scholz; Dierk Thomas; Christian Weidenhammer; Sven Kathöfer; Alexander Bauer; Hugo A Katus; Christoph A Karle
Kir2.x inward rectifier potassium channels are differentially regulated by adrenergic alpha1A receptors.
Journal of molecular and cellular cardiology 2008;44(1):84-94.
2007: Kamilla Kelemen; Claudia Seyler; Edgar Zitron; Alexander Bauer; Eberhard P Scholz; Ramona Bloehs; Dierk Thomas; Johannes Greten; Andrew Remppis; Wolfgang Schoels; Hugo A Katus; Christoph A Karle
Green tea flavonoid epigallocatechin-3-gallate (EGCG) inhibits cardiac hERG potassium channels.
Biochemical and biophysical research communications 2007;364(3):429-35.
2007: Eberhard P Scholz; Franziska M Konrad; Daniel L Weiss; Edgar Zitron; Claudia Seyler; Ramona Bloehs; Martin Kulzer; Dierk Thomas; Sven Kathöfer; Alexander Bauer; Martin H Maurer; Gunnar Seemann; Hugo A Katus; Christoph A Karle
Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656.
Naunyn-Schmiedeberg's archives of pharmacology 2007;376(4):275-84.
2007: Eberhard P Scholz; Edgar Zitron; Claudia Seyler; Dierk Thomas; Sven Kathöfer; Jörg Kreuzer; Alexander Bauer; Hugo A Katus; Andrew Remppis; Christoph A Karle; Johannes Greten
Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2007;17(9):666-75.
2007: Wei Zhang; Edgar Zitron; Meike Hömme; Lars Kihm; Christian Morath; Daniel Scherer; Stephan Hegge; Dierk Thomas; Claus Peter Schmitt; Martin Zeier; Hugo Katus; Christoph A Karle; Vedat Schwenger
Aquaporin-1 channel function is positively regulated by protein kinase C.
The Journal of biological chemistry 2007;282(29):20933-40.
2007: Daniel Scherer; Claudia Seyler; Martin Kulzer; Myriam Günth; Eberhard P Scholz; Sven Kathöfer; Dierk Thomas; Martin Maurer; Jörg Kreuzer; Alexander Bauer; Hugo A Katus; Christoph A Karle; Edgar Zitron
Activation of inwardly rectifying Kir2.x potassium channels by beta 3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2.
Naunyn-Schmiedeberg's archives of pharmacology 2007;375(5):311-22.
2007: Eberhard P Scholz; Edgar Zitron; Hugo A Katus; Christoph A Karle; Derliz Mereles
Atrial septal aneurysm mimicking ECG signs of enlarged right atrium.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2007;9(7):475-6.
2006: Eberhard P Scholz; Markus Alter; Edgar Zitron; Claudia Seyler; Sven Kathöfer; Dierk Thomas; Volker A W Kreye; Jörg Kreuzer; Ruediger Becker; Hugo A Katus; Johannes Greten; Christoph A Karle
In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform.
Toxicology letters 2006;165(2):156-66.
2006: Claudia Seyler; Markus Alter; Sven Kathöfer; Edgar Zitron; Eberhard P Scholz; Dierk Thomas; Jörg Kreuzer; Hugo A Katus; Alexander Bauer; Christoph A Karle
Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels.
Naunyn-Schmiedeberg's archives of pharmacology 2006;373(3):212-20.
2006: Dierk Thomas; Christoph A Karle; Johann Kiehn
The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications.
Current pharmaceutical design 2006;12(18):2271-83.
2006: Simon Peth; Christoph A Karle; Christoph Dehnert; Peter Bärtsch; Heimo Mairbäurl
K+ channel activation with minoxidil stimulates nasal-epithelial ion transport and blunts exaggerated hypoxic pulmonary hypertension.
High altitude medicine & biology 2006;7(1):54-63.
2006: Claudia Seyler; Edgar Zitron; Daniel Scherer; Sonja Lueck; Ramona Bloehs; Eberhard P Scholz; Marcus Pirot; Sven Kathöfer; Dierk Thomas; Volker A W Kreye; Johann Kiehn; Mathias M Borst; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1.
Journal of molecular medicine (Berlin, Germany) 2006;84(1):46-56.
2005: Edgar Zitron; Eberhard P Scholz; Claudia Seyler; M Pirot; Sven Kathöfer; Dierk Thomas; Johann Kiehn; Hugo A Katus; Ruediger Becker; Christoph A Karle
[Molecular basis of primary electrical heart diseases].
Herzschrittmachertherapie & Elektrophysiologie 2005;16(4):229-38.
2005: Dierk Thomas; Anna-Britt Wimmer; Christoph A Karle; Manuela Licka; Markus Alter; Markus Khalil; Herbert E Ulmer; Sven Kathöfer; Johann Kiehn; Hugo A Katus; Wolfgang Schoels; Michael Koenen; Joerg Zehelein
Dominant-negative I(Ks) suppression by KCNQ1-deltaF339 potassium channels linked to Romano-Ward syndrome.
Cardiovascular research 2005;67(3):487-97.
2005: Eberhard P Scholz; Edgar Zitron; Claudia Seyler; Sonja Lück; Dierk Thomas; Sven Kathöfer; Volker A W Kreye; Hugo A Katus; Johann Kiehn; Wolfgang Schoels; Christoph A Karle
Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation.
Naunyn-Schmiedeberg's archives of pharmacology 2005;371(6):516-25.
2005: Edgar Zitron; Eberhard P Scholz; Robert W Owen; Sonja Lück; Claudia Seyler; Dierk Thomas; Sven Kathöfer; Feraydoon Niroomand; Johann Kiehn; Volker A W Kreye; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
QTc prolongation by grapefruit juice and its potential pharmacological basis: HERG channel blockade by flavonoids.
Circulation 2005;111(7):835-8.
2005: Sven Kathofer; Dierk Thomas; Christoph A Karle
The novel antiarrhythmic drug dronedarone: comparison with amiodarone.
Cardiovascular drug reviews 2005;23(3):217-30.
2004: Claudia Seyler; Edgar Zitron; Sonja Lück; Ramona Bloehs; Eberhard P Scholz; Sven Kathöfer; Dierk Thomas; Volker A W Kreye; Hugo A Katus; Wolfgang Schoels; Christoph A Karle; Johann Kiehn
Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action.
Naunyn-Schmiedeberg's archives of pharmacology 2004;370(6):423-35.
2004: Dierk Thomas; Bettina C Hammerling; Anna-Britt Wimmer; Kezhong Wu; Eckhard Ficker; Yuri A Kuryshev; Daniel Scherer; Johann Kiehn; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X).
Cardiovascular research 2004;64(3):467-76.
2004: Dierk Thomas; Kezhong Wu; Anna-Britt Wimmer; Edgar Zitron; Bettina C Hammerling; Sven Kathöfer; Sonja Lueck; Ramona Bloehs; Volker A W Kreye; Johann Kiehn; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by alpha(1A)-adrenoceptors.
Journal of molecular medicine (Berlin, Germany) 2004;82(12):826-37.
2004: Joerg Zehelein; Dierk Thomas; Markus Khalil; Anna-Britt Wimmer; Michael Koenen; Manuela Licka; Kezhong Wu; Johann Kiehn; Konrad Brockmeier; Volker A W Kreye; Christoph A Karle; Hugo A Katus; Herbert E Ulmer; Wolfgang Schoels
Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome.
Biochimica et biophysica acta 2004;1690(3):185-92.
2004: Edgar Zitron; Claudia Seyler; Sonja Lück; Sven Kathöfer; Dierk Thomas; Volker A W Kreye; Johann Kiehn; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
Human cardiac inwardly rectifying current IKir2.2 is upregulated by activation of protein kinase A.
Cardiovascular research 2004;63(3):520-7.
2004: Edgar Zitron; Claudia Seyler; Eberhard P Scholz; Sonja Lück; Ramona Bloehs; Sven Kathöfer; Dierk Thomas; Johann Kiehn; Volker A W Kreye; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone.
Naunyn-Schmiedeberg's archives of pharmacology 2004;370(2):146-56.
2004: Dierk Thomas; Johann Kiehn; Hugo A Katus; Christoph A Karle
Adrenergic regulation of the rapid component of the cardiac delayed rectifier potassium current, I(Kr), and the underlying hERG ion channel.
Basic research in cardiology 2004;99(4):279-87.
2004: Dierk Thomas; Bettina C Hammerling; Kezhong Wu; Anna-Britt Wimmer; Eckhard Ficker; Glenn E Kirsch; Mary C Kochan; Barbara A Wible; Eberhard P Scholz; Edgar Zitron; Sven Kathöfer; Volker A W Kreye; Hugo A Katus; Wolfgang Schoels; Christoph A Karle; Johann Kiehn
Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action.
British journal of pharmacology 2004;142(3):485-94.
2004: Christoph A Karle; Tobias Gehrig; Ralf Wodopia; Sabine Höschele; Volker A W Kreye; Hugo A Katus; Peter Bärtsch; Heimo Mairbäurl
Hypoxia-induced inhibition of whole cell membrane currents and ion transport of A549 cells.
American journal of physiology. Lung cellular and molecular physiology 2004;286(6):L1154-60.
2004: Dierk Thomas; Anna-Britt Wimmer; Kezhong Wu; Bettina C Hammerling; Eckhard Ficker; Yuri A Kuryshev; Johann Kiehn; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin.
Naunyn-Schmiedeberg's archives of pharmacology 2004;369(5):462-72.
2004: Dierk Thomas; Christoph A Karle; Johann Kiehn
Modulation of HERG potassium channel function by drug action.
Annals of medicine 2004;36 Suppl 1():41-6.
2004: Dierk Thomas; Ruediger Becker; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
Radiation therapy-induced electrical reset of an implantable cardioverter defibrillator device located outside the irradiation field.
Journal of electrocardiology 2004;37(1):73-4.
2003: Dierk Thomas; Johann Kiehn; Hugo A Katus; Christoph A Karle
Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): molecular mechanisms and restoration of intracellular protein processing.
Cardiovascular research 2003;60(2):235-41.
2003: Eberhard P Scholz; Edgar Zitron; Claudia Seyler; Sonja Lueck; Sven Kathöfer; Dierk Thomas; Slawomir Weretka; Simon Peth; Volker A W Kreye; Wolfgang Schoels; Hugo A Katus; Johann Kiehn; Christoph A Karle
Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine.
Naunyn-Schmiedeberg's archives of pharmacology 2003;368(5):404-14.
2003: Dierk Thomas; Sven Kathofer; Wei Zhang; Kezhong Wu; Anna-Britt Wimmer; Edgar Zitron; Volker A W Kreye; Hugo A Katus; Wolfgang Schoels; Christoph A Karle; Johann Kiehn
Acute effects of dronedarone on both components of the cardiac delayed rectifier K+ current, HERG and KvLQT1/minK potassium channels.
British journal of pharmacology 2003;140(5):996-1002.
2003: Sven Kathöfer; Katja Röckl; Wei Zhang; Dierk Thomas; Hugo Katus; Johann Kiehn; Volker A W Kreye; Wolfgang Schoels; Christoph A Karle
Human beta(3)-adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein.
Naunyn-Schmiedeberg's archives of pharmacology 2003;368(2):119-26.
2003: Dierk Thomas; Wei Zhang; Kezhong Wu; Anna-Britt Wimmer; Bernd Gut; Gunnar Wendt-Nordahl; Sven Kathöfer; Volker A W Kreye; Hugo A Katus; Wolfgang Schoels; Johann Kiehn; Christoph A Karle
Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein.
Cardiovascular research 2003;59(1):14-26.
2003: Dierk Thomas; Bernd Gut; Syrus Karsai; Anna-Britt Wimmer; Kezhong Wu; Gunnar Wendt-Nordahl; Wei Zhang; Sven Kathöfer; Wolfgang Schoels; Hugo A Katus; Johann Kiehn; Christoph A Karle
Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen.
Naunyn-Schmiedeberg's archives of pharmacology 2003;368(1):41-8.
2003: Dierk Thomas; Kezhong Wu; Sven Kathöfer; Hugo A Katus; Wolfgang Schoels; Johann Kiehn; Christoph A Karle
The antipsychotic drug chlorpromazine inhibits HERG potassium channels.
British journal of pharmacology 2003;139(3):567-74.
2003: Slawomir Weretka; Jochen Michaelsen; Ruediger Becker; Christoph A Karle; Frederik Voss; Thomas Hilbel; Brigitte R Osswald; Malte L Bahner; Julia C Senges; Wolfgang M Kuebler; Wolfgang Schoels
Ventricular oversensing: a study of 101 patients implanted with dual chamber defibrillators and two different lead systems.
Pacing and clinical electrophysiology : PACE 2003;26(1 Pt 1):65-70.
2002: Christoph A Karle; Edgar Zitron; Wei Zhang; Gunnar Wendt-Nordahl; Sven Kathöfer; Dierk Thomas; Bernd Gut; Eberhard P Scholz; Christian F Vahl; Hugo A Katus; Johann Kiehn
Human cardiac inwardly-rectifying K+ channel Kir(2.1b) is inhibited by direct protein kinase C-dependent regulation in human isolated cardiomyocytes and in an expression system.
Circulation 2002;106(12):1493-9.
2002: Edgar Zitron; Christoph A Karle; Gunnar Wendt-Nordahl; Sven Kathöfer; Wei Zhang; Dierk Thomas; Slawomir Weretka; Johann Kiehn
Bertosamil blocks HERG potassium channels in their open and inactivated states.
British journal of pharmacology 2002;137(2):221-8.
2002: Zhang Wei; Dierk Thomas; Christoph A Karle; Sven Kathöfer; Johannes Schenkel; Volker A W Kreye; Eckhard Ficker; Barbara A Wible; Johann Kiehn
Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line.
Chinese medical journal 2002;115(5):668-76.
2002: Alexander Bauer; Ruediger Becker; Christoph A Karle; Kirsten D Schreiner; Julia C Senges; Frederik Voss; Patricia Kraft; Wolfgang M Kuebler; Wolfgang Schoels
Effects of the I(Kr)-blocking agent dofetilide and of the I(Ks)-blocking agent chromanol 293b on regional disparity of left ventricular repolarization in the intact canine heart.
Journal of cardiovascular pharmacology 2002;39(3):460-7.
2002: Christoph A Karle; Edgar Zitron; Wei Zhang; Sven Kathöfer; Wolfgang Schoels; Johann Kiehn
Rapid component I(Kr) of the guinea-pig cardiac delayed rectifier K(+) current is inhibited by beta(1)-adrenoreceptor activation, via cAMP/protein kinase A-dependent pathways.
Cardiovascular research 2002;53(2):355-62.
2002: Christoph A Karle; Dierk Thomas; Johann Kiehn
The antiarrhythmic drug BRL-32872.
Cardiovascular drug reviews 2002;20(2):111-20.
2002: Christoph A Karle; Alexander Bauer; Slawomir Weretka; Edgar Zitron; Adel Abushi; Volker A W Kreye; Wolfgang Schoels
Vascular effects of class-III antiarrhythmic drugs: chromanol 293B, but not dofetilide blocks the smooth muscle delayed rectifier K+ channel.
Basic research in cardiology 2002;97(1):17-25.
2002: Christoph A Karle; Johann Kiehn
An ion channel 'addicted' to ether, alcohol and cocaine: the HERG potassium channel.
Cardiovascular research 2002;53(1):6-8.
2001: Slawomir Weretka; Ruediger Becker; Thomas Hilbel; Christoph A Karle; Brigitte R Osswald; Wolfgang M Kuebler; Wolfgang Schoels
Far-field R wave oversensing in a dual chamber arrhythmia management device: predisposing factors and practical implications.
Pacing and clinical electrophysiology : PACE 2001;24(8 Pt 1):1240-6.
2001: Christoph A Karle; Volker A W Kreye; Dierk Thomas; Katja Röckl; Sven Kathöfer; Wei Zhang; Johann Kiehn
Antiarrhythmic drug carvedilol inhibits HERG potassium channels.
Cardiovascular research 2001;49(2):361-70.
2000: Sven Kathöfer; Wei Zhang; Christoph A Karle; Dierk Thomas; Wolfgang Schoels; Johann Kiehn
Functional coupling of human beta 3-adrenoreceptors to the KvLQT1/MinK potassium channel.
The Journal of biological chemistry 2000;275(35):26743-7.
1999: Dierk Thomas; Wei Zhang; Christoph A Karle; Sven Kathöfer; W Schöls; Wolfgang Kübler; Johann Kiehn
Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A.
The Journal of biological chemistry 1999;274(39):27457-62.
1999: Johann Kiehn; Dierk Thomas; Christoph A Karle; W Schöls; Wolfgang Kübler
Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels.
Naunyn-Schmiedeberg's archives of pharmacology 1999;359(3):212-9.
1998: Johann Kiehn; Christoph A Karle; Dierk Thomas; X Yao; Johannes Brachmann; Wolfgang Kübler
HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways.
The Journal of biological chemistry 1998;273(39):25285-91.
1998: Christoph A Karle; X Yao; Volker A W Kreye
A K+ single channel and whole-cell clamp study on the effects of levocromakalim in guinea pig portal vein cells.
Naunyn-Schmiedeberg's archives of pharmacology 1998;358(3):374-81.