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Anders Karlén
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31
Hallberg, Anders
20
Lindeberg, Gunnar
16
Nyberg, Fred
10
Hacksell, Uli
10
Botros, Milad
9
Samuelsson, Bertil
9
Sköld, Christian
8
Schaal, Wesley
7
Gogoll, Adolf
7
Larhed, Mats
6
Johansson, Anette
6
Plouffe, Bianca
6
Gallo-Payet, Nicole
6
Unge, Torsten
5
Vrang, Lotta
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All Publications
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2009: Nilsson Mikael T; Krajewski Wojciech W; Yellagunda Sujan; Prabhumurthy Savitha; Chamarahally Gayathri N; Siddamadappa Chandrasekharan; Srinivasa Bachally R; Yahiaoui Samir; Larhed Mats; Karlén Anders; Jones T Alwyn; Mowbray Sherry L
Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors.
Journal of molecular biology 2009;393(2):504-13.
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2009: Odell Luke R; Nilsson Mikael T; Gising Johan; Lagerlund Olof; Muthas Daniel; Nordqvist Anneli; Karlén Anders; Larhed Mats
Functionalized 3-amino-imidazo[1,2-a]pyridines: a novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(16):4790-3.
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2008: Andersson Hanna; Demaegdt Heidi; Vauquelin Georges; Lindeberg Gunnar; Karlén Anders; Hallberg Mathias
Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2.
Bioorganic & medicinal chemistry 2008;16(14):6924-35.
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2008: Muthas Daniel; Sabnis Yogesh A; Lundborg Magnus; Karlén Anders
Is it possible to increase hit rates in structure-based virtual screening by pharmacophore filtering? An investigation of the advantages and pitfalls of post-filtering.
Journal of molecular graphics & modelling 2008;26(8):1237-51.
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2008: Nordqvist Anneli; Nilsson Mikael T; Röttger Svenja; Odell Luke R; Krajewski Wojciech W; Evalena Andersson C; Larhed Mats; Mowbray Sherry L; Karlén Anders
Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery.
Bioorganic & medicinal chemistry 2008;16(10):5501-13.
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2008: Nurbo Johanna; Peterson Shane D; Dahl Göran; Helena Danielson U; Karlén Anders; Sandström Anja
Beta-amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitors.
Bioorganic & medicinal chemistry 2008;16(10):5590-605.
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2008: Jacobsson Micael; Gäredal Magnus; Schultz Johan; Karlén Anders
Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening.
Journal of medicinal chemistry 2008;51(9):2777-86.
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2008: Rönn Robert; Lampa Anna; Peterson Shane D; Gossas Thomas; Akerblom Eva; Danielson U Helena; Karlén Anders; Sandström Anja
Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety.
Bioorganic & medicinal chemistry 2008;16(6):2955-67.
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2008: Sköld Christian; Nikiforovich Gregory; Karlén Anders
Modeling binding modes of angiotensin II and pseudopeptide analogues to the AT2 receptor.
Journal of molecular graphics & modelling 2008;26(6):991-1003.
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2007: Nurbo Johanna; Roos Annette K; Muthas Daniel; Wahlström Erik; Ericsson Daniel J; Lundstedt Torbjörn; Unge Torsten; Karlén Anders
Design, synthesis and evaluation of peptide inhibitors of Mycobacterium tuberculosis ribonucleotide reductase.
Journal of peptide science : an official publication of the European Peptide Society 2007;13(12):822-32.
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2007: Lagerlund Olof; Odell Luke R; Mowbray Sherry L; Nilsson Mikael T; Krajewski Wojciech W; Nordqvist Anneli; Karlén Anders; Larhed Mats
Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase.
Combinatorial chemistry & high throughput screening 2007;10(9):783-9.
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2007: Sunnerheim Kerstin; Nordqvist Anneli; Nordlander Göran; Borg-Karlson Anna-Karin; Unelius C Rickard; Bohman Björn; Nordenhem Henrik; Hellqvist Claes; Karlén Anders
Quantitative structure-activity relationships of pine weevil antifeedants, a multivariate approach.
Journal of agricultural and food chemistry 2007;55(23):9365-72.
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2007: Murugaiah A M S; Wallinder Chalotta; Mahalingam A K; Wu Xiongyu; Wan Yiqian; Plouffe Bianca; Botros Milad; Karlén Anders; Hallberg Mathias; Gallo-Payet Nicole; Alterman Mathias
Selective angiotensin II AT(2) receptor agonists devoid of the imidazole ring system.
Bioorganic & medicinal chemistry 2007;15(22):7166-83.
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2007: Axén Andreas; Andersson Hanna; Lindeberg Gunnar; Rönnholm Harriet; Kortesmaa Jarkko; Demaegdt Heidi; Vauquelin Georges; Karlén Anders; Hallberg Mathias
Small potent ligands to the insulin-regulated aminopeptidase (IRAP)/AT(4) receptor.
Journal of peptide science : an official publication of the European Peptide Society 2007;13(7):434-44.
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2007: Sköld Christian; Karlén Anders
Development of CoMFA models of affinity and selectivity to angiotensin II type-1 and type-2 receptors.
Journal of molecular graphics & modelling 2007;26(1):145-53.
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2007: Georgsson Jennie; Sköld Christian; Botros Milad; Lindeberg Gunnar; Nyberg Fred; Karlén Anders; Hallberg Anders; Larhed Mats
Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor.
Journal of medicinal chemistry 2007;50(7):1711-5.
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2007: Ortqvist Pernilla; Peterson Shane D; Kerblom Eva; Gossas Thomas; Sabnis Yogesh A; Fransson Rebecca; Lindeberg Gunnar; Helena Danielson U; Karlén Anders; Sandström Anja
Phenylglycine as a novel P2 scaffold in hepatitis C virus NS3 protease inhibitors.
Bioorganic & medicinal chemistry 2007;15(3):1448-74.
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2006: Sköld Christian; Winiwarter Susanne; Wernevik Johan; Bergström Fredrik; Engström Leif; Allen Ruth; Box Karl; Comer John; Mole Jon; Hallberg Anders; Lennernäs Hans; Lundstedt Torbjörn; Ungell Anna-Lena; Karlén Anders
Presentation of a structurally diverse and commercially available drug data set for correlation and benchmarking studies.
Journal of medicinal chemistry 2006;49(23):6660-71.
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2006: Wu Xiongyu; Wan Yiqian; Mahalingam A K; Murugaiah A M S; Plouffe Bianca; Botros Milad; Karlén Anders; Hallberg Mathias; Gallo-Payet Nicole; Alterman Mathias
Selective angiotensin II AT2 receptor agonists: arylbenzylimidazole structure-activity relationships.
Journal of medicinal chemistry 2006;49(24):7160-8.
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2006: Axén Andreas; Lindeberg Gunnar; Demaegdt Heidi; Vauquelin Georges; Karlén Anders; Hallberg Mathias
Cyclic insulin-regulated aminopeptidase (IRAP)/AT4 receptor ligands.
Journal of peptide science : an official publication of the European Peptide Society 2006;12(11):705-13.
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2006: Rosenström Ulrika; Sköld Christian; Lindeberg Gunnar; Botros Milad; Nyberg Fred; Karlén Anders; Hallberg Anders
Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT1 and AT2 receptors.
Journal of medicinal chemistry 2006;49(20):6133-7.
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2006: Georgsson Jennie; Rosenström Ulrika; Wallinder Charlotta; Beaudry Hélène; Plouffe Bianca; Lindeberg Gunnar; Botros Milad; Nyberg Fred; Karlén Anders; Gallo-Payet Nicole; Hallberg Anders
Short pseudopeptides containing turn scaffolds with high AT2 receptor affinity.
Bioorganic & medicinal chemistry 2006;14(17):5963-72.
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2006: Wannberg Johan; Sabnis Yogesh A; Vrang Lotta; Samuelsson Bertil; Karlén Anders; Hallberg Anders; Larhed Mats
A new structural theme in C2-symmetric HIV-1 protease inhibitors: ortho-substituted P1/P1' side chains.
Bioorganic & medicinal chemistry 2006;14(15):5303-15.
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2006: Jacobsson Micael; Karlén Anders
Ligand bias of scoring functions in structure-based virtual screening.
Journal of chemical information and modeling 2006;46(3):1334-43.
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2006: Peterson Shane D; Schaal Wesley; Karlén Anders
Improved CoMFA modeling by optimization of settings.
Journal of chemical information and modeling 2006;46(1):355-64.
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2005: Erdélyi Máté; Karlén Anders; Gogoll Adolf
A new tool in peptide engineering: a photoswitchable stilbene-type beta-hairpin mimetic.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;12(2):403-12.
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2005: Georgsson Jennie; Sköld Christian; Plouffe Bianca; Lindeberg Gunnar; Botros Milad; Larhed Mats; Nyberg Fred; Gallo-Payet Nicole; Gogoll Adolf; Karlén Anders; Hallberg Anders
Angiotensin II pseudopeptides containing 1,3,5-trisubstituted benzene scaffolds with high AT2 receptor affinity.
Journal of medicinal chemistry 2005;48(21):6620-31.
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2005: Muthas Daniel; Nöteberg Daniel; Sabnis Yogesh A; Hamelink Elizabeth; Vrang Lotta; Samuelsson Bertil; Karlén Anders; Hallberg Anders
Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II.
Bioorganic & medicinal chemistry 2005;13(18):5371-90.
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2005: Rosenström Ulrika; Sköld Christian; Plouffe Bianca; Beaudry Hélène; Lindeberg Gunnar; Botros Milad; Nyberg Fred; Wolf Gunter; Karlén Anders; Gallo-Payet Nicole; Hallberg Anders
New selective AT2 receptor ligands encompassing a gamma-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists.
Journal of medicinal chemistry 2005;48(12):4009-24.
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2005: Ax Anna; Schaal Wesley; Vrang Lotta; Samuelsson Bertil; Hallberg Anders; Karlén Anders
Cyclic sulfamide HIV-1 protease inhibitors, with sidechains spanning from P2/P2' to P1/P1'.
Bioorganic & medicinal chemistry 2005;13(3):755-64.
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2004: Johannesson Petra; Erdélyi Máté; Lindeberg Gunnar; Frändberg Per-Anders; Nyberg Fred; Karlén Anders; Hallberg Anders
AT2-selective angiotensin II analogues containing tyrosine-functionalized 5,5-bicyclic thiazabicycloalkane dipeptide mimetics.
Journal of medicinal chemistry 2004;47(24):6009-19.
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2004: Wan Yiqian; Wallinder Charlotta; Plouffe Bianca; Beaudry Hélène; Mahalingam A K; Wu Xiongyu; Johansson Berndt; Holm Mathias; Botoros Milad; Karlén Anders; Pettersson Anders; Nyberg Fred; Fändriks Lars; Gallo-Payet Nicole; Hallberg Anders; Alterman Mathias
Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist.
Journal of medicinal chemistry 2004;47(24):5995-6008.
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2004: Rosenström U; Sköld C; Lindeberg G; Botros M; Nyberg F; Hallberg A; Karlén A
Synthesis and AT2 receptor-binding properties of angiotensin II analogues.
The journal of peptide research : official journal of the American Peptide Society 2004;64(5):194-201.
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2004: Afzelius Lovisa; Raubacher Florian; Karlén Anders; Jørgensen Flemming Steen; Andersson Tommy B; Masimirembwa Collen M; Zamora Ismael
Structural analysis of CYP2C9 and CYP2C5 and an evaluation of commonly used molecular modeling techniques.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(11):1218-29.
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2004: Wan Yiqian; Wallinder Charlotta; Johansson Berndt; Holm Mathias; Mahalingam A K; Wu Xiongyu; Botros Milad; Karlén Anders; Pettersson Anders; Nyberg Fred; Fändriks Lars; Hallberg Anders; Alterman Mathias
First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo.
Journal of medicinal chemistry 2004;47(6):1536-46.
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2004: Afzelius Lovisa; Zamora Ismael; Masimirembwa Collen M; Karlén Anders; Andersson Tommy B; Mecucci Silvio; Baroni Massimo; Cruciani Gabriele
Conformer- and alignment-independent model for predicting structurally diverse competitive CYP2C9 inhibitors.
Journal of medicinal chemistry 2004;47(4):907-14.
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2004: Rosenström Ulrika; Sköld Christian; Lindeberg Gunnar; Botros Milad; Nyberg Fred; Karlén Anders; Hallberg Anders
A selective AT2 receptor ligand with a gamma-turn-like mimetic replacing the amino acid residues 4-5 of angiotensin II.
Journal of medicinal chemistry 2004;47(4):859-70.
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2004: Roos Annette K; Andersson C Evalena; Bergfors Terese; Jacobsson Micael; Karlén Anders; Unge Torsten; Jones T Alwyn; Mowbray Sherry L
Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site.
Journal of molecular biology 2004;335(3):799-809.
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2003: Lindman Susanna; Lindeberg Gunnar; Frändberg Per-Anders; Nyberg Fred; Karlén Anders; Hallberg Anders
Effect of 3-5 monocyclizations of angiotensin II and 4-aminoPhe6-Ang II on AT2 receptor affinity.
Bioorganic & medicinal chemistry 2003;11(13):2947-54.
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2003: Andersson Hans O; Fridborg Kerstin; Löwgren Seved; Alterman Mathias; Mühlman Anna; Björsne Magnus; Garg Neeraj; Kvarnström Ingmar; Schaal Wesley; Classon Björn; Karlén Anders; Danielsson U Helena; Ahlsén Göran; Nillroth Ullrika; Vrang Lotta; Oberg Bo; Samuelsson Bertil; Hallberg Anders; Unge Torsten
Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors.
European journal of biochemistry / FEBS 2003;270(8):1746-58.
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2003: Schmidt Boris; Kühn Christian; Ehlert Dennis K; Lindeberg Gunnar; Lindman Susanna; Karlén Anders; Hallberg Anders
A frame shifted disulfide bridged analogue of angiotensin II.
Bioorganic & medicinal chemistry 2003;11(6):985-90.
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2003: Winiwarter Susanne; Ax Fredrik; Lennernäs Hans; Hallberg Anders; Pettersson Curt; Karlén Anders
Hydrogen bonding descriptors in the prediction of human in vivo intestinal permeability.
Journal of molecular graphics & modelling 2003;21(4):273-87.
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2002: Markgren Per-Olof; Schaal Wesley; Hämäläinen Markku; Karlén Anders; Hallberg Anders; Samuelsson Bertil; Danielson U Helena
Relationships between structure and interaction kinetics for HIV-1 protease inhibitors.
Journal of medicinal chemistry 2002;45(25):5430-9.
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2002: Afzelius Lovisa; Masimirembwa Collen M; Karlén Anders; Andersson Tommy B; Zamora Ismael
Discriminant and quantitative PLS analysis of competitive CYP2C9 inhibitors versus non-inhibitors using alignment independent GRIND descriptors.
Journal of computer-aided molecular design 2002;16(7):443-58.
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2002: Johannesson Petra; Lindeberg Gunnar; Johansson Anja; Nikiforovich Gregory V; Gogoll Adolf; Synnergren Barbro; Le Grèves Madeleine; Nyberg Fred; Karlén Anders; Hallberg Anders
Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor.
Journal of medicinal chemistry 2002;45(9):1767-77.
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2001: Lagerquist C; Beigi F; Karlén A; Lennernäs H; Lundahl P
Effects of cholesterol and model transmembrane proteins on drug partitioning into lipid bilayers as analysed by immobilized-liposome chromatography.
The Journal of pharmacy and pharmacology 2001;53(11):1477-87.
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2001: Afzelius L; Zamora I; Ridderström M; Andersson T B; Karlén A; Masimirembwa C M
Competitive CYP2C9 inhibitors: enzyme inhibition studies, protein homology modeling, and three-dimensional quantitative structure-activity relationship analysis.
Molecular pharmacology 2001;59(4):909-19.
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2001: Lindman S; Lindeberg G; Gogoll A; Nyberg F; Karlén A; Hallberg A
Synthesis, receptor binding affinities and conformational properties of cyclic methylenedithioether analogues of angiotensin II.
Bioorganic & medicinal chemistry 2001;9(3):763-72.
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2001: Schaal W; Karlsson A; Ahlsén G; Lindberg J; Andersson H O; Danielson U H; Classon B; Unge T; Samuelsson B; Hultén J; Hallberg A; Karlén A
Synthesis and comparative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors.
Journal of medicinal chemistry 2001;44(2):155-69.
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2000: Hämäläinen M D; Markgren P O; Schaal W; Karlén A; Classon B; Vrang L; Samuelsson B; Hallberg A; Danielson U H
Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor-based screen.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2000;5(5):353-60.
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2000: Lindman S; Lindeberg G; Nyberg F; Karlén A; Hallberg A
Comparison of three gamma-turn mimetic scaffolds incorporated into angiotensin II.
Bioorganic & medicinal chemistry 2000;8(9):2375-83.
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2000: Danelian E; Karlén A; Karlsson R; Winiwarter S; Hansson A; Löfâs S; Lennernäs H; Hämäläinen M D
SPR biosensor studies of the direct interaction between 27 drugs and a liposome surface: correlation with fraction absorbed in humans.
Journal of medicinal chemistry 2000;43(11):2083-6.
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1999: Johannesson P; Lindeberg G; Tong W; Gogoll A; Synnergren B; Nyberg F; Karlén A; Hallberg A
Angiotensin II analogues encompassing 5,9- and 5,10-fused thiazabicycloalkane tripeptide mimetics.
Journal of medicinal chemistry 1999;42(22):4524-37.
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1999: Hultén J; Andersson H O; Schaal W; Danielson H U; Classon B; Kvarnström I; Karlén A; Unge T; Samuelsson B; Hallberg A
Inhibitors of the C(2)-symmetric HIV-1 protease: nonsymmetric binding of a symmetric cyclic sulfamide with ketoxime groups in the P2/P2' side chains.
Journal of medicinal chemistry 1999;42(20):4054-61.
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1999: Johannesson P; Lindeberg G; Tong W; Gogoll A; Karlén A; Hallberg A
Bicyclic tripeptide mimetics with reverse turn inducing properties.
Journal of medicinal chemistry 1999;42(4):601-8.
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1998: Winiwarter S; Bonham N M; Ax F; Hallberg A; Lennernäs H; Karlén A
Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach.
Journal of medicinal chemistry 1998;41(25):4939-49.
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1997: Schmidt B; Lindman S; Tong W; Lindeberg G; Gogoll A; Lai Z; Thörnwall M; Synnergren B; Nilsson A; Welch C J; Sohtell M; Westerlund C; Nyberg F; Karlén A; Hallberg A
Design, synthesis, and biological activities of four angiotensin II receptor ligands with gamma-turn mimetics replacing amino acid residues 3-5.
Journal of medicinal chemistry 1997;40(6):903-19.
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1997: Bäckbro K; Löwgren S; Osterlund K; Atepo J; Unge T; Hultén J; Bonham N M; Schaal W; Karlén A; Hallberg A
Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor.
Journal of medicinal chemistry 1997;40(6):898-902.
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1997: Hultén J; Bonham N M; Nillroth U; Hansson T; Zuccarello G; Bouzide A; Aqvist J; Classon B; Danielson U H; Karlén A; Kvarnström I; Samuelsson B; Hallberg A
Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities.
Journal of medicinal chemistry 1997;40(6):885-97.
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1994: Johansson A M; Grol C J; Karlén A; Hacksell U
Dopamine D2 receptor agonists: an analysis of indirect models.
Drug design and discovery 1994;11(2):159-74.
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1993: Jansen J M; Karlén A; Grol C J; Hacksell U
Conformational properties of melatonin and two conformationally restricted agonists: a molecular mechanics and NMR spectroscopic study.
Drug design and discovery 1993;10(2):115-33.
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1989: Karlén A; Helander A; Kenne L; Hacksell U
Topography and conformational preferences of 6,7,8,9-tetrahydro-1-hydroxy-N,N-dipropyl-5H-benzocyclohepten-6- ylamin e. A rationale for the dopaminergic inactivity.
Journal of medicinal chemistry 1989;32(4):765-74.
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1989: Karlén A; Hacksell U; Helander A; Kenne L
Why are benzocycloheptenylamines inactive as dopamine D2-receptor agonists?
Progress in clinical and biological research 1989;291():281-4.
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1988: Mellin C; Björk L; Karlén A; Johansson A M; Sundell S; Kenne L; Nelson D L; Andén N E; Hacksell U
Central dopaminergic and 5-hydroxytryptaminergic effects of C3-methylated derivatives of 8-hydroxy-2-(di-n-propylamino)tetralin.
Journal of medicinal chemistry 1988;31(6):1130-40.
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1988: Arvidsson L E; Karlén A; Norinder U; Kenne L; Sundell S; Hacksell U
Structural factors of importance for 5-hydroxytryptaminergic activity. Conformational preferences and electrostatic potentials of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and some related agents.
Journal of medicinal chemistry 1988;31(1):212-21.
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1987: Johansson A M; Nilsson J L; Karlén A; Hacksell U; Sanchez D; Svensson K; Hjorth S; Carlsson A; Sundell S; Kenne L
C1- and C3-methyl-substituted derivatives of 7-hydroxy-2-(di-n-propylamino)tetralin: activities at central dopamine receptors.
Journal of medicinal chemistry 1987;30(10):1827-37.
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1987: Johansson A M; Nilsson J L; Karlén A; Hacksell U; Svensson K; Carlsson A; Kenne L; Sundell S
C3-methylated 5-hydroxy-2-(dipropylamino)tetralins: conformational and steric parameters of importance for central dopamine receptor activation.
Journal of medicinal chemistry 1987;30(7):1135-44.
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1986: Johansson A M; Karlén A; Grol C J; Sundell S; Kenne L; Hacksell U
Dopaminergic 2-aminotetralins: affinities for dopamine D2-receptors, molecular structures, and conformational preferences.
Molecular pharmacology 1986;30(3):258-69.
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1986: Karlén A; Johansson A M; Kenne L; Arvidsson L E; Hacksell U
Conformational analysis of the dopamine-receptor agonist 5-hydroxy-2-(dipropylamino)tetralin and its C(2)-methyl-substituted derivative.
Journal of medicinal chemistry 1986;29(6):917-24.
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