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Morris Karmazyn

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Venkatesh Rajapurohitam; Eduardo Martinez-Abundis; Farzad Izaddoustdar; Morris Karmazyn
Leptin-induced cardiomyocyte hypertrophy reveals both calcium-dependent and calcium-independent/RhoA-dependent calcineurin activation and NFAT nuclear translocation.
John D Huber; Paul Kaplita; Morris Karmazyn; Raymond Kemper; Charles A Kennedy; Thomas M Kirrane; Jeffrey Madwed; Elizabeth Mainolfi; Nelamangara Nagaraja; Fariba Soleymanzadeh; Alan Swinamer; Jörg Bentzien; Stephen J Boyer; Jennifer Burke; Stéphane De Lombaert; Christian Eickmeier; Xin Guo; James V Haist; Eugene R Hickey; Anne B Eldrup
Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.
Jian Ma; Hao Wang; Qiang Wang; Meng Wei; Guo-Chang Fan; Peter A Greer; Morris Karmazyn; James C Lacefield; Jianmin Li; Weihua Liu; Tianqing Peng
Deficiency of Capn4 gene inhibits nuclear factor-κB (NF-κB) protein signaling/inflammation and reduces remodeling after myocardial infarction.

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All Publications

2012: Venkatesh Rajapurohitam; Eduardo Martinez-Abundis; Farzad Izaddoustdar; Morris Karmazyn
Leptin-induced cardiomyocyte hypertrophy reveals both calcium-dependent and calcium-independent/RhoA-dependent calcineurin activation and NFAT nuclear translocation.
Cellular signalling 2012;24(12):2283-90.
2012: John D Huber; Paul Kaplita; Morris Karmazyn; Raymond Kemper; Charles A Kennedy; Thomas M Kirrane; Jeffrey Madwed; Elizabeth Mainolfi; Nelamangara Nagaraja; Fariba Soleymanzadeh; Alan Swinamer; Jörg Bentzien; Stephen J Boyer; Jennifer Burke; Stéphane De Lombaert; Christian Eickmeier; Xin Guo; James V Haist; Eugene R Hickey; Anne B Eldrup
Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.
Journal of medicinal chemistry 2012;55(16):7114-40.
2012: Jian Ma; Hao Wang; Qiang Wang; Meng Wei; Guo-Chang Fan; Peter A Greer; Morris Karmazyn; James C Lacefield; Jianmin Li; Weihua Liu; Tianqing Peng
Deficiency of Capn4 gene inhibits nuclear factor-κB (NF-κB) protein signaling/inflammation and reduces remodeling after myocardial infarction.
The Journal of biological chemistry 2012;287(33):27480-9.
2012: Melissa Moey; Venkatesh Rajapurohitam; Xiaohong Tracey Gan; Cathy Xiaoling Huang; Edmund M K Lui; Eduardo Martínez-Abundis; Morris Karmazyn
Ginseng reverses established cardiomyocyte hypertrophy and postmyocardial infarction-induced hypertrophy and heart failure.
Circulation. Heart failure 2012;5(4):504-14.
2012: Venkatesh Rajapurohitam; Ana Kilic; Sabzali Javadov; Morris Karmazyn
Role of NF-κB and p38 MAPK activation in mediating angiotensin II and endothelin-1-induced stimulation in leptin production and cardiomyocyte hypertrophy.
Molecular and cellular biochemistry 2012;366(1-2):287-97.
2012: Xiaohong Tracey Gan; Cathy Huang; J Craig Hunter; Sabzali Javadov; Venkatesh Rajapurohitam; Jenny Xue; Morris Karmazyn
Ouabain increases iNOS-dependent nitric oxide generation which contributes to the hypertrophic effect of the glycoside: possible role of peroxynitrite formation.
Molecular and cellular biochemistry 2012;363(1-2):323-33.
2012: Eduardo Martinez-Abundis; Venkatesh Rajapurohitam; Xiaohong Tracey Gan; James V Haist; Morris Karmazyn
The obesity-related peptide leptin sensitizes cardiac mitochondria to calcium-induced permeability transition pore opening and apoptosis.
PloS one 2012;7(7):e41612.
2011: Melissa Moey; Venkatesh Rajapurohitam; Asad Zeidan; Morris Karmazyn
Ginseng (Panax quinquefolius) attenuates leptin-induced cardiac hypertrophy through inhibition of p115Rho guanine nucleotide exchange factor-RhoA/Rho-associated, coiled-coil containing protein kinase-dependent mitogen-activated protein kinase pathway activation.
The Journal of pharmacology and experimental therapeutics 2011;339(3):746-56.
2011: Morris Karmazyn; Melissa Moey; Xiaohong Tracey Gan
Therapeutic potential of ginseng in the management of cardiovascular disorders.
Drugs 2011;71(15):1989-2008.
2011: Fatima Mraiche; Tatsujiro Oka; Xiaohong Tracey Gan; Morris Karmazyn; Larry Fliegel
Activated NHE1 is required to induce early cardiac hypertrophy in mice.
Basic research in cardiology 2011;106(4):603-16.
2011: Asad Zeidan; J Craig Hunter; Sabzali Javadov; Morris Karmazyn
mTOR mediates RhoA-dependent leptin-induced cardiomyocyte hypertrophy.
Molecular and cellular biochemistry 2011;352(1-2):99-108.
2011: Juan Guo; Xiaohong Tracey Gan; James V Haist; Venkatesh Rajapurohitam; Asad Zeidan; Nazo Said Faruq; Morris Karmazyn
Ginseng inhibits cardiomyocyte hypertrophy and heart failure via NHE-1 inhibition and attenuation of calcineurin activation.
Circulation. Heart failure 2011;4(1):79-88.
2011: Sabzali Javadov; Venkatesh Rajapurohitam; Ana Kilić; J Craig Hunter; Asad Zeidan; Nazo Said Faruq; Nelson Escobales; Morris Karmazyn
Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition.
Basic research in cardiology 2011;106(1):99-109.
2010: Ana Kilic; Venkatesh Rajapurohitam; Sharon M Sandberg; Asad Zeidan; J Craig Hunter; Nazo Said Faruq; Candace Y Lee; John C Burnett; Morris Karmazyn
A novel chimeric natriuretic peptide reduces cardiomyocyte hypertrophy through the NHE-1-calcineurin pathway.
Cardiovascular research 2010;88(3):434-42.
2010: Jin Xue; Fatima Mraiche; Dan Zhou; Morris Karmazyn; Tatsujiro Oka; Larry Fliegel; Gabriel G Haddad
Elevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy.
Physiological genomics 2010;42(3):374-83.
2010: Theresa Pang; Venkatesh Rajapurohitam; Michael A Cook; Morris Karmazyn
Differential AMPK phosphorylation sites associated with phenylephrine vs. antihypertrophic effects of adenosine agonists in neonatal rat ventricular myocytes.
American journal of physiology. Heart and circulatory physiology 2010;298(5):H1382-90.
2010: Theresa Pang; Xiaohong Tracey Gan; David J Freeman; Michael A Cook; Morris Karmazyn
Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes.
American journal of physiology. Heart and circulatory physiology 2010;298(2):H545-53.
2010: Xiaohong Tracey Gan; Xiang-Qun Gong; Jenny Xue; James V Haist; Donglin Bai; Morris Karmazyn
Sodium-hydrogen exchange inhibition attenuates glycoside-induced hypertrophy in rat ventricular myocytes.
Cardiovascular research 2010;85(1):79-89.
2009: J Craig Hunter; Asad Zeidan; Sabzali Javadov; Ana Kilić; Venkatesh Rajapurohitam; Morris Karmazyn
Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway.
Journal of molecular and cellular cardiology 2009;47(6):810-8.
2009: Sabzali Javadov; Morris Karmazyn; Nelson Escobales
Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases.
The Journal of pharmacology and experimental therapeutics 2009;330(3):670-8.
2009: Pijush Majumdar; Shali Chen; Biju George; Subhrojit Sen; Morris Karmazyn; Subrata Chakrabarti
Leptin and endothelin-1 mediated increased extracellular matrix protein production and cardiomyocyte hypertrophy in diabetic heart disease.
Diabetes/metabolism research and reviews 2009;25(5):452-63.
2009: Sabzali Javadov; Venkatesh Rajapurohitam; Ana Kilić; Asad Zeidan; Angel Choi; Morris Karmazyn
Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.
Journal of molecular and cellular cardiology 2009;46(6):998-1007.
2009: Na Li; Xiangru Lu; Xiaohui Zhao; Fu-Li Xiang; Anargyros Xenocostas; Morris Karmazyn; Qingping Feng
Endothelial nitric oxide synthase promotes bone marrow stromal cell migration to the ischemic myocardium via upregulation of stromal cell-derived factor-1alpha.
Stem cells (Dayton, Ohio) 2009;27(4):961-70.
2009: Ana Kilić; Sabzali Javadov; Morris Karmazyn
Estrogen exerts concentration-dependent pro-and anti-hypertrophic effects on adult cultured ventricular myocytes. Role of NHE-1 in estrogen-induced hypertrophy.
Journal of molecular and cellular cardiology 2009;46(3):360-9.
2008: Seta Stanbouly; Lorrie A Kirshenbaum; Douglas L Jones; Morris Karmazyn
Sodium hydrogen exchange 1 (NHE-1) regulates connexin 43 expression in cardiomyocytes via reverse mode sodium calcium exchange and c-Jun NH2-terminal kinase-dependent pathways.
The Journal of pharmacology and experimental therapeutics 2008;327(1):105-13.
2008: Morris Karmazyn; Dan Purdham; Venkatesh Rajapurohitam; Asad Zeidan
Signalling mechanisms underlying the metabolic and other effects of adipokines on the heart.
Cardiovascular research 2008;79(2):279-86.
2008: Dan Purdham; Venkatesh Rajapurohitam; Asad Zeidan; Cathy Huang; Garrett J Gross; Morris Karmazyn
A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart.
American journal of physiology. Heart and circulatory physiology 2008;295(1):H441-6.
2008: Morris Karmazyn; Ana Kilić; Sabzali Javadov
The role of NHE-1 in myocardial hypertrophy and remodelling.
Journal of molecular and cellular cardiology 2008;44(4):647-53.
2008: Sabzali Javadov; Angel Choi; Venkatesh Rajapurohitam; Asad Zeidan; Alexei G Basnakian; Morris Karmazyn
NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition.
Cardiovascular research 2008;77(2):416-24.
2008: Ling Chen; Jin Zhang; Tracey X Gan; Ye Chen-Izu; Jeffrey D Hasday; Morris Karmazyn; C William Balke; Steven M Scharf
Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;104(1):218-23.
2008: Asad Zeidan; Sabzali Javadov; Subrata Chakrabarti; Morris Karmazyn
Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei.
Cardiovascular research 2008;77(1):64-72.
2007: Asad Zeidan; Ben Paylor; Karly J Steinhoff; Sabzali Javadov; Venkatesh Rajapurohitam; Subrata Chakrabarti; Morris Karmazyn
Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK- and phosphatidylinositol 3-kinase/protein kinase B-dependent pathways.
The Journal of pharmacology and experimental therapeutics 2007;322(3):1110-6.
2007: Morris Karmazyn; Dan Purdham; Venkatesh Rajapurohitam; Asad Zeidan
Leptin as a cardiac hypertrophic factor: a potential target for therapeutics.
Trends in cardiovascular medicine 2007;17(6):206-11.
2007: David B Thorp; James V Haist; Jennifer Leppard; Kevin J Milne; Morris Karmazyn; Earl G Noble
Exercise training improves myocardial tolerance to ischemia in male but not in female rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(1):R363-71.
2007: Shali Chen; Zia Ali KHAN; Morris Karmazyn; Subrata Chakrabarti
Role of endothelin-1, sodium hydrogen exchanger-1 and mitogen activated protein kinase (MAPK) activation in glucose-induced cardiomyocyte hypertrophy.
Diabetes/metabolism research and reviews 2007;23(5):356-67.
2007: Bernardo V Alvarez; Danielle E Johnson; Daniel Sowah; Daniel Soliman; Peter E Light; Ying Xia; Morris Karmazyn; Joseph R Casey
Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy.
The Journal of physiology 2007;579(Pt 1):127-45.
2007: Sabzali Javadov; Morris Karmazyn
Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;20(1-4):1-22.
2007: Ying Xia; Sabzali Javadov; Tracey X Gan; Theresa Pang; Michael A Cook; Morris Karmazyn
Distinct KATP channels mediate the antihypertrophic effects of adenosine receptor activation in neonatal rat ventricular myocytes.
The Journal of pharmacology and experimental therapeutics 2007;320(1):14-21.
2006: Asad Zeidan; Morris Karmazyn
Leptin and vascular smooth muscle.
Current vascular pharmacology 2006;4(4):383-93.
2006: Asad Zeidan; Sabzali Javadov; Morris Karmazyn
Essential role of Rho/ROCK-dependent processes and actin dynamics in mediating leptin-induced hypertrophy in rat neonatal ventricular myocytes.
Cardiovascular research 2006;72(1):101-11.
2006: Sabzali Javadov; Dan Purdham; Asad Zeidan; Morris Karmazyn
NHE-1 inhibition improves cardiac mitochondrial function through regulation of mitochondrial biogenesis during postinfarction remodeling.
American journal of physiology. Heart and circulatory physiology 2006;291(4):H1722-30.
2006: Min-Xu Zou; Anju Anne Roy; Qingshi Zhao; Lorrie A Kirshenbaum; Morris Karmazyn; Peter Chidiac
RGS2 is upregulated by and attenuates the hypertrophic effect of alpha1-adrenergic activation in cultured ventricular myocytes.
Cellular signalling 2006;18(10):1655-63.
2006: Venkatesh Rajapurohitam; Sabzali Javadov; Dan Purdham; Lorrie A Kirshenbaum; Morris Karmazyn
An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1.
Journal of molecular and cellular cardiology 2006;41(2):265-74.
2006: Venkatachalem Sathish; Ande Xu; Morris Karmazyn; Stephen M Sims; Njanoor Narayanan
Mechanistic basis of differences in Ca2+ -handling properties of sarcoplasmic reticulum in right and left ventricles of normal rat myocardium.
American journal of physiology. Heart and circulatory physiology 2006;291(1):H88-96.
2006: Sabzali Javadov; Delphine Baetz; Venkatesh Rajapurohitam; Asad Zeidan; Lorrie A Kirshenbaum; Morris Karmazyn
Antihypertrophic effect of Na+/H+ exchanger isoform 1 inhibition is mediated by reduced mitogen-activated protein kinase activation secondary to improved mitochondrial integrity and decreased generation of mitochondrial-derived reactive oxygen species.
The Journal of pharmacology and experimental therapeutics 2006;317(3):1036-43.
2005: Asad Zeidan; Dan Purdham; Venkatesh Rajapurohitam; Sabzali Javadov; Subrata Chakrabarti; Morris Karmazyn
Leptin induces vascular smooth muscle cell hypertrophy through angiotensin II- and endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy.
The Journal of pharmacology and experimental therapeutics 2005;315(3):1075-84.
2005: Morris Karmazyn; M Sawyer; Larry Fliegel
The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention.
Current drug targets. Cardiovascular & haematological disorders 2005;5(4):323-35.
2005: Sabzali Javadov; Cathy Huang; Lorrie A Kirshenbaum; Morris Karmazyn
NHE-1 inhibition improves impaired mitochondrial permeability transition and respiratory function during postinfarction remodelling in the rat.
Journal of molecular and cellular cardiology 2005;38(1):135-43.
2005: Xiaohong Tracey Gan; Venkatesh Rajapurohitam; James V Haist; Peter Chidiac; Michael A Cook; Morris Karmazyn
Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes.
The Journal of pharmacology and experimental therapeutics 2005;312(1):27-34.
2004: Larry Fliegel; Morris Karmazyn
The cardiac Na-H exchanger: a key downstream mediator for the cellular hypertrophic effects of paracrine, autocrine and hormonal factors.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2004;82(6):626-35.
2004: Dan Purdham; Min-Xu Zou; Venkatesh Rajapurohitam; Morris Karmazyn
Rat heart is a site of leptin production and action.
American journal of physiology. Heart and circulatory physiology 2004;287(6):H2877-84.
2004: Ying Xia; Venkatesh Rajapurohitam; Michael A Cook; Morris Karmazyn
Inhibition of phenylephrine induced hypertrophy in rat neonatal cardiomyocytes by the mitochondrial KATP channel opener diazoxide.
Journal of molecular and cellular cardiology 2004;37(5):1063-7.
2004: Ying Xia; Morris Karmazyn
Obligatory role for endogenous endothelin in mediating the hypertrophic effects of phenylephrine and angiotensin II in neonatal rat ventricular myocytes: evidence for two distinct mechanisms for endothelin regulation.
The Journal of pharmacology and experimental therapeutics 2004;310(1):43-51.
2004: Mark Cukiernik; Denise Hileeto; Donal B Downey; Terry Evans; Zia Ali KHAN; Morris Karmazyn; Subrata Chakrabarti
The role of the sodium hydrogen exchanger-1 in mediating diabetes-induced changes in the retina.
Diabetes/metabolism research and reviews 2004;20(1):61-71.
2004: Ling Chen; Chang-xun Chen; Xiaohong Tracey Gan; Norbert Beier; Wolfgang Scholz; Morris Karmazyn
Inhibition and reversal of myocardial infarction-induced hypertrophy and heart failure by NHE-1 inhibition.
American journal of physiology. Heart and circulatory physiology 2004;286(1):H381-7.
2003: Hana Farhangkhoee; Zia Ali KHAN; Suranjana Mukherjee; Mark Cukiernik; Yousef P Barbin; Morris Karmazyn; Subrata Chakrabarti
Heme oxygenase in diabetes-induced oxidative stress in the heart.
Journal of molecular and cellular cardiology 2003;35(12):1439-48.
2003: Morris Karmazyn; Que Liu; Xiaohong Tracey Gan; Brenda J Brix; Larry Fliegel
Aldosterone increases NHE-1 expression and induces NHE-1-dependent hypertrophy in neonatal rat ventricular myocytes.
Hypertension 2003;42(6):1171-6.
2003: Venkatesh Rajapurohitam; Xiaohong Tracey Gan; Lorrie A Kirshenbaum; Morris Karmazyn
The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes.
Circulation research 2003;93(4):277-9.
2003: James V Haist; Claire N Hirst; Morris Karmazyn
Effective protection by NHE-1 inhibition in ischemic and reperfused heart under preconditioning blockade.
American journal of physiology. Heart and circulatory physiology 2003;284(3):H798-803.
2003: Xiaohong Tracey Gan; Subrata Chakrabarti; Morris Karmazyn
Increased endothelin-1 and endothelin receptor expression in myocytes of ischemic and reperfused rat hearts and ventricular myocytes exposed to ischemic conditions and its inhibition by nitric oxide generation.
Canadian journal of physiology and pharmacology 2003;81(2):105-13.
2002: Denise Hileeto; Mark Cukiernik; Suranjana Mukherjee; Terry Evans; Yousef P Barbin; Donal B Downey; Morris Karmazyn; Subrata Chakrabarti
Contributions of endothelin-1 and sodium hydrogen exchanger-1 in the diabetic myocardium.
Diabetes/metabolism research and reviews 2002;18(5):386-94.
2002: Zain Paroo; Michael J (Michael) Meredith; Marius Locke; James V Haist; Morris Karmazyn; Earl G Noble
Redox signaling of cardiac HSF1 DNA binding.
American journal of physiology. Cell physiology 2002;283(2):C404-11.
2002: Zain Paroo; James V Haist; Morris Karmazyn; Earl G Noble
Exercise improves postischemic cardiac function in males but not females: consequences of a novel sex-specific heat shock protein 70 response.
Circulation research 2002;90(8):911-7.
2002: Melanie E Holmes; James Mwanjewe; Sue E Samson; James V Haist; John X Wilson; S Jeffrey Dixon; Morris Karmazyn; Ashok K Grover
Dehydroascorbic acid uptake by coronary artery smooth muscle: effect of intracellular acidification.
The Biochemical journal 2002;362(Pt 2):507-12.
2001: R Daskalopoulos; Jasminka Korcok; P Farhangkhgoee; Morris Karmazyn; Adrian W Gelb; John X Wilson
Propofol protection of sodium-hydrogen exchange activity sustains glutamate uptake during oxidative stress.
Anesthesia and analgesia 2001;93(5):1199-204.
2001: Ling Chen; Xiaohong Tracey Gan; James V Haist; Q Feng; X Lu; Subrata Chakrabarti; Morris Karmazyn
Attenuation of compensatory right ventricular hypertrophy and heart failure following monocrotaline-induced pulmonary vascular injury by the Na+-H+ exchange inhibitor cariporide.
The Journal of pharmacology and experimental therapeutics 2001;298(2):469-76.
2001: Morris Karmazyn
Role of sodium-hydrogen exchange in cardiac hypertrophy and heart failure: a novel and promising therapeutic target.
Basic research in cardiology 2001;96(4):325-8.
2001: AN Moor; Xiaohong Tracey Gan; Morris Karmazyn; Larry Fliegel
Activation of Na+/H+ exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium.
The Journal of biological chemistry 2001;276(19):16113-22.
2001: Morris Karmazyn
Therapeutic potential of Na-H exchange inhibitors for the treatment of heart failure.
Expert opinion on investigational drugs 2001;10(5):835-43.
2001: K Kusumoto; James V Haist; Morris Karmazyn
Na(+)/H(+) exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats.
American journal of physiology. Heart and circulatory physiology 2001;280(2):H738-45.
2001: Morris Karmazyn; J V Sostaric; Xiaohong Tracey Gan
The myocardial Na+/H+ exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure.
Drugs 2001;61(3):375-89.
2000: S Chen; T Evans; K Mukherjee; Morris Karmazyn; Subrata Chakrabarti
Diabetes-induced myocardial structural changes: role of endothelin-1 and its receptors.
Journal of molecular and cellular cardiology 2000;32(9):1621-9.
2000: N Hoque; Michael A Cook; Morris Karmazyn
Inhibition of alpha(1)-adrenergic-mediated responses in rat ventricular myocytes by adenosine A(1) receptor activation: role of the K(ATP) channel.
The Journal of pharmacology and experimental therapeutics 2000;294(2):770-7.
2000: Morris Karmazyn
Pharmacology and clinical assessment of cariporide for the treatment coronary artery diseases.
Expert opinion on investigational drugs 2000;9(5):1099-108.
2000: H Yoshida; Morris Karmazyn
Na(+)/H(+) exchange inhibition attenuates hypertrophy and heart failure in 1-wk postinfarction rat myocardium.
American journal of physiology. Heart and circulatory physiology 2000;278(1):H300-4.
1999: S Mathur; P Farhangkhgoee; Morris Karmazyn
Cardioprotective effects of propofol and sevoflurane in ischemic and reperfused rat hearts: role of K(ATP) channels and interaction with the sodium-hydrogen exchange inhibitor HOE 642 (cariporide).
Anesthesiology 1999;91(5):1349-60.
1999: Morris Karmazyn; Xiaohong Tracey Gan; R A Humphreys; H Yoshida; K Kusumoto
The myocardial Na(+)-H(+) exchange: structure, regulation, and its role in heart disease.
Circulation research 1999;85(9):777-86.
1999: Xiaohong Tracey Gan; Subrata Chakrabarti; Morris Karmazyn
Modulation of Na+/H+ exchange isoform 1 mRNA expression in isolated rat hearts.
The American journal of physiology 1999;277(3 Pt 2):H993-8.
1999: R R Neviere; Gediminas Cepinskas; W Sean Madorin; N Hoque; Morris Karmazyn; William J Sibbald; Peter R Kvietys
LPS pretreatment ameliorates peritonitis-induced myocardial inflammation and dysfunction: role of myocytes.
The American journal of physiology 1999;277(3 Pt 2):H885-92.
1999: Morris Karmazyn
Mechanisms of protection of the ischemic and reperfused myocardium by sodium-hydrogen exchange inhibition.
Journal of thrombosis and thrombolysis 1999;8(1):33-8.
1999: Morris Karmazyn
The role of the myocardial sodium-hydrogen exchanger in mediating ischemic and reperfusion injury. From amiloride to cariporide.
Annals of the New York Academy of Sciences 1999;874():326-34.
1999: GP Thomas; Morris Karmazyn; Andrew C Zygmunt; Charles Antzelevitch; N Narayanan
The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes.
British journal of pharmacology 1999;126(7):1531-3.
1999: R A Humphreys; James V Haist; Subrata Chakrabarti; Q Feng; J Malcolm O Arnold; Morris Karmazyn
Orally administered NHE1 inhibitor cariporide reduces acute responses to coronary occlusion and reperfusion.
The American journal of physiology 1999;276(2 Pt 2):H749-57.
1998: GP Thomas; Stephen M Sims; Michael A Cook; Morris Karmazyn
Hydrogen peroxide-induced stimulation of L-type calcium current in guinea pig ventricular myocytes and its inhibition by adenosine A1 receptor activation.
The Journal of pharmacology and experimental therapeutics 1998;286(3):1208-14.
1998: Morris Karmazyn
The myocardial sodium-hydrogen exchanger (NHE) and its role in mediating ischemic and reperfusion injury.
The Keio journal of medicine 1998;47(2):65-72.
1998: Subrata Chakrabarti; Xiaohong Tracey Gan; A Merry; Morris Karmazyn; Anders A F Sima
Augmented retinal endothelin-1, endothelin-3, endothelinA and endothelinB gene expression in chronic diabetes.
Current eye research 1998;17(3):301-7.
1998: Xiaohong Tracey Gan; Michael A Cook; M P Moffat; Morris Karmazyn
Protective effects against hydrogen peroxide-induced toxicity by activators of the ATP-sensitive potassium channel in isolated rat hearts.
Journal of molecular and cellular cardiology 1998;30(1):33-41.
1997: S Mathur; Morris Karmazyn
Interaction between anesthetics and the sodium-hydrogen exchange inhibitor HOE 642 (cariporide) in ischemic and reperfused rat hearts.
Anesthesiology 1997;87(6):1460-9.
1997: K M Zimmer; Morris Karmazyn
Prostaglandins attenuate cardiac contractile dysfunction produced by free radical generation but not by hydrogen peroxide.
Molecular and cellular biochemistry 1997;176(1-2):171-8.
1997: Subrata Chakrabarti; AN Hoque; Morris Karmazyn
A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide).
Journal of molecular and cellular cardiology 1997;29(11):3169-74.
1997: GP Thomas; Stephen M Sims; Morris Karmazyn
Differential effects of endothelin-1 on basal and isoprenaline-enhanced Ca2+ current in guinea-pig ventricular myocytes.
The Journal of physiology 1997;503 ( Pt 1)():55-65.
1997: AN Hoque; Morris Karmazyn
Effect of sodium-hydrogen exchange inhibition on functional and metabolic impairment produced by oxidative stress in the isolated rat heart.
Canadian journal of physiology and pharmacology 1997;75(4):326-34.
1997: AN Hoque; James V Haist; Morris Karmazyn
Na(+)-H+ exchange inhibition protects against mechanical, ultrastructural, and biochemical impairment induced by low concentrations of lysophosphatidylcholine in isolated rat hearts.
Circulation research 1997;80(1):95-102.
1996: Morris Karmazyn
The sodium-hydrogen exchange system in the heart: its role in ischemic and reperfusion injury and therapeutic implications.
The Canadian journal of cardiology 1996;12(10):1074-82.
1996: Y Ebihara; Morris Karmazyn
Inhibition of beta- but not alpha 1-mediated adrenergic responses in isolated hearts and cardiomyocytes by nitric oxide and 8-bromo cyclic GMP.
Cardiovascular research 1996;32(3):622-9.
1996: Xiaohong Tracey Gan; Michael A Cook; M P Moffat; Morris Karmazyn
Transient ischemia in the presence of an adenosine deaminase plus a nucleoside transport inhibitor confers protection against contractile depression produced by hydrogen peroxide. Possible role of glycogen.
Journal of molecular and cellular cardiology 1996;28(5):1165-76.
1996: M L Myers; Morris Karmazyn
Improved cardiac function after prolonged hypothermic ischemia with the Na+/H+ exchange inhibitor HOE 694.
The Annals of thoracic surgery 1996;61(5):1400-6.
1996: Y Ebihara; James V Haist; Morris Karmazyn
Modulation of endothelin-1 effects on rat hearts and cardiomyocytes by nitric oxide and 8-bromo cyclic GMP.
Journal of molecular and cellular cardiology 1996;28(2):265-77.
1996: Michael A Cook; Morris Karmazyn
Cardioprotective actions of adenosine and adenosine analogs.
EXS 1996;76():325-44.
1996: John R Bend; Morris Karmazyn
Role of eicosanoids in the ischemic and reperfused myocardium.
EXS 1996;76():243-62.
1996: Morris Karmazyn
The role of endothelins in cardiac function in health and disease.
EXS 1996;76():209-30.
1995: M L Myers; S Mathur; G H Li; Morris Karmazyn
Sodium-hydrogen exchange inhibitors improve postischemic recovery of function in the perfused rabbit heart.
Cardiovascular research 1995;29(2):209-14.
1994: N Khandoudi; J Ho; Morris Karmazyn
Role of Na(+)-H+ exchange in mediating effects of endothelin-1 on normal and ischemic/reperfused hearts.
Circulation research 1994;75(2):369-78.
1994: N Khandoudi; M P Moffat; Morris Karmazyn
Adenosine-sensitive alpha 1-adrenoceptor effects on reperfused ischaemic hearts: comparison with phorbol ester.
British journal of pharmacology 1994;112(4):1007-16.
1993: M P Moffat; Morris Karmazyn
Protective effects of the potent Na/H exchange inhibitor methylisobutyl amiloride against post-ischemic contractile dysfunction in rat and guinea-pig hearts.
Journal of molecular and cellular cardiology 1993;25(8):959-71.
1993: Morris Karmazyn; M P Moffat
Role of Na+/H+ exchange in cardiac physiology and pathophysiology: mediation of myocardial reperfusion injury by the pH paradox.
Cardiovascular research 1993;27(6):915-24.
1993: M P Moffat; C A Ward; John R Bend; T Mock; P Farhangkhoee; Morris Karmazyn
Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes.
The American journal of physiology 1993;264(4 Pt 2):H1154-60.
1993: Morris Karmazyn; James V Haist
Calcium dependent positive inotropic effects of low phorbol ester concentrations in isolated rat hearts.
Cardiovascular research 1993;27(3):390-5.
1993: Morris Karmazyn
Na+/H+ exchange inhibitors reverse lactate-induced depression in postischaemic ventricular recovery.
British journal of pharmacology 1993;108(1):50-6.
1993: Morris Karmazyn; M Ray; James V Haist
Comparative effects of Na+/H+ exchange inhibitors against cardiac injury produced by ischemia/reperfusion, hypoxia/reoxygenation, and the calcium paradox.
Journal of cardiovascular pharmacology 1993;21(1):172-8.
1992: Morris Karmazyn; Michael A Cook
Adenosine A1 receptor activation attenuates cardiac injury produced by hydrogen peroxide.
Circulation research 1992;71(5):1101-10.
1992: J Duan; Morris Karmazyn
Protective effects of amiloride on the ischemic reperfused rat heart. Relation to mitochondrial function.
European journal of pharmacology 1992;210(2):149-57.
1991: J E Watson; Morris Karmazyn
Concentration-dependent effects of protein kinase C-activating and -nonactivating phorbol esters on myocardial contractility, coronary resistance, energy metabolism, prostacyclin synthesis, and ultrastructure in isolated rat hearts. Effects of amiloride.
Circulation research 1991;69(4):1114-31.
1991: Morris Karmazyn
The 1990 Merck Frosst Award. Ischemic and reperfusion injury in the heart. Cellular mechanisms and pharmacological interventions.
Canadian journal of physiology and pharmacology 1991;69(6):719-30.
1990: Morris Karmazyn; M P Moffat
Positive inotropic effects of low concentrations of leukotrienes C4 and D4 in rat heart.
The American journal of physiology 1990;259(4 Pt 2):H1239-46.
1990: Morris Karmazyn; J E Watson; M P Moffat
Mechanisms for cardiac depression induced by phorbol myristate acetate in working rat hearts.
British journal of pharmacology 1990;100(4):826-30.
1989: Morris Karmazyn
Synthesis and relevance of cardiac eicosanoids with particular emphasis on ischemia and reperfusion.
Canadian journal of physiology and pharmacology 1989;67(8):912-21.
1989: M P Moffat; Gregory R Ferrier; Morris Karmazyn
A direct role of endogenous prostaglandins in reperfusion-induced cardiac arrhythmias.
Canadian journal of physiology and pharmacology 1989;67(7):772-9.