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Klas Kärre

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Anatomy

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Lymphoma

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Genes, MHC Class I

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Rossana Tallerico; Luca Tirinato; Matilde Todaro; Enzo Di Fabrizio; Simone Di Franco; Francesco Dieli; Cinzia Garofalo; Klas Kärre; Rosanna La Rocca; Cristina Maccalli; Ofer Mandelboim; Alessandro Moretta; Camillo Palmieri; Pradeepa N Pangigadde; Giorgio Parmiani; Rosa Sottile; Giorgio Stassi; Ennio Carbone
Human NK cells selective targeting of colon cancer-initiating cells: a role for natural cytotoxicity receptors and MHC class I molecules.
Michal Sternberg-Simon; Björn Onfelt; Yishai Pickman; Petter Brodin; Petter Höglund; Klas Kärre; Karl-Johan Malmberg; Ramit Mehr
Natural killer cell inhibitory receptor expression in humans and mice: a closer look.
Yinghui Li; Sven Pettersson; Shih Wee Seow; Klas Kärre; Parag Kundu; Linda Aronsson; Keh-Chuang Chin; Cristina Teixeira de Matos; Gediminas Greicius
Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APCMin/+ mice.

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All Publications

2013: Rossana Tallerico; Luca Tirinato; Matilde Todaro; Enzo Di Fabrizio; Simone Di Franco; Francesco Dieli; Cinzia Garofalo; Klas Kärre; Rosanna La Rocca; Cristina Maccalli; Ofer Mandelboim; Alessandro Moretta; Camillo Palmieri; Pradeepa N Pangigadde; Giorgio Parmiani; Rosa Sottile; Giorgio Stassi; Ennio Carbone
Human NK cells selective targeting of colon cancer-initiating cells: a role for natural cytotoxicity receptors and MHC class I molecules.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(5):2381-90.
2013: Michal Sternberg-Simon; Björn Onfelt; Yishai Pickman; Petter Brodin; Petter Höglund; Klas Kärre; Karl-Johan Malmberg; Ramit Mehr
Natural killer cell inhibitory receptor expression in humans and mice: a closer look.
Frontiers in immunology 2013;4():65.
2012: Yinghui Li; Sven Pettersson; Shih Wee Seow; Klas Kärre; Parag Kundu; Linda Aronsson; Keh-Chuang Chin; Cristina Teixeira de Matos; Gediminas Greicius
Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APCMin/+ mice.
Carcinogenesis 2012;33(6):1231-8.
2012: Jens Gertow; Klas Kärre; Jonas Mattsson; Mantas Okas; Mats Remberger; Sofia Berglund; Michael Uhlin
Expansion of T-cells from the cord blood graft as a predictive tool for complications and outcome of cord blood transplantation.
Clinical immunology (Orlando, Fla.) 2012;143(2):134-44.
2012: Aniruddha Choudhury; Petter Höglund; Klas Kärre; Rolf Kiessling; Andreas Lundqvist; Kalle Malmberg; Håkan Mellstedt; Annika Scheynius; Ola Winqvist; Anders Osterborg
First International Meeting of the Thematic Centre for Immune Modulatory Therapies for Autoimmunity and Cancer (IMTAC) 13-14 June 2011, Ljusterö, Sweden.
Cancer immunology, immunotherapy : CII 2012;61(4):587-91.
2012: Petter Brodin; Klas Kärre; Tadepally Lakshmikanth; Petter Höglund
Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(5):2218-26.
2011: Susanne E Johansson; Klas Kärre; Stephen J Kent; Erik Rollman; Ivan Stratov; Britta Wahren; Rob J Center; Amy W Chung; Bo Hejdeman; Jorma Hinkula; Louise Berg
NK cell function and antibodies mediating ADCC in HIV-1-infected viremic and controller patients.
Viral immunology 2011;24(5):359-68.
2011: Hai Li; Clemens Spinnler; Laszlo Szekely; Andrea Anichini; Ennio Carbone; Martin Enge; Cinzia Garofalo; Klas Kärre; Tadepally Lakshmikanth; Galina Selivanova
Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2.
Cell cycle (Georgetown, Tex.) 2011;10(19):3346-58.
2011: Elisabeth Franzen-Röhl; Danika Schepis; Maria Lagrelius; Kristina Franck; Petra Jones; Jan-Åke Liljeqvist; Tomas Bergström; Elisabeth Aurelius; Klas Kärre; Louise Berg; Hans Gaines
Increased cell-mediated immune responses in patients with recurrent herpes simplex virus type 2 meningitis.
Clinical and vaccine immunology : CVI 2011;18(4):655-60.
2010: J Gertow; S Berglund; M Okas; Mehmet Uzunel; Louise Berg; Klas Kärre; Jonas Mattsson; Michael Uhlin
Characterization of long-term mixed donor-donor chimerism after double cord blood transplantation.
Clinical and experimental immunology 2010;162(1):146-55.
2010: Hanna Brauner; Marjet Elemans; Sara Lemos; Christian Broberger; Dan Holmberg; Malin Flodström-Tullberg; Klas Kärre; Petter Höglund
Distinct phenotype and function of NK cells in the pancreas of nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(5):2272-80.
2010: Gustaf Vahlne; Katja Lindholm; Anders Meier; Stina Wickström; Tadepally Lakshmikanth; Frank Brennan; Michael Wilken; Rikke Nielsen; François Romagné; Nicolai R Wagtmann; Klas Kärre; MH Johansson
In vivo tumor cell rejection induced by NK cell inhibitory receptor blockade: maintained tolerance to normal cells even in the presence of IL-2.
European journal of immunology 2010;40(3):813-23.
2010: Susanne E Johansson; Bo Hejdeman; Jorma Hinkula; MH Johansson; François Romagné; Britta Wahren; Nicolai R Wagtmann; Klas Kärre; Louise Berg
NK cell activation by KIR-binding antibody 1-7F9 and response to HIV-infected autologous cells in viremic and controller HIV-infected patients.
Clinical immunology (Orlando, Fla.) 2010;134(2):158-68.
2010: Petter Brodin; Tadepally Lakshmikanth; Ramit Mehr; MH Johansson; Adil Doganay Duru; Adnane Achour; Mali Salmon-Divon; Klas Kärre; Petter Höglund; Sofia Johansson
Natural killer cell tolerance persists despite significant reduction of self MHC class I on normal target cells in mice.
PloS one 2010;5(10):.
2010: Mantas Okas; Jens Gertow; Mehmet Uzunel; Helen Karlsson; Magnus Westgren; Klas Kärre; Olle Ringden; Jonas Mattsson; Michael Uhlin
Clinical expansion of cord blood-derived T cells for use as donor lymphocyte infusion after cord blood transplantation.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2010;33(1):96-105.
2009: Sebastian Thams; Petter Brodin; Stefan Plantman; Robert Saxelin; Klas Kärre; Staffan Cullheim
Classical major histocompatibility complex class I molecules in motoneurons: new actors at the neuromuscular junction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(43):13503-15.
2009: D Schepis; Mauro D'Amato; Marie Studahl; T Bergström; Klas Kärre; Louise Berg
Herpes simplex virus infection downmodulates NKG2D ligand expression.
Scandinavian journal of immunology 2009;69(5):429-36.
2009: Tadepally Lakshmikanth; Shannon Burke; Talib Hassan Ali; Silvia Kimpfler; Francesco Ursini; Loredana Ruggeri; Marusca Capanni; Viktor Umansky; Annette Paschen; Antje Sucker; Daniela Pende; Veronika Groh; Roberto Biassoni; Petter Höglund; Masashi Kato; Kazuko Shibuya; Dirk Schadendorf; Andrea Anichini; Soldano Ferrone; Andrea Velardi; Klas Kärre; Akira Shibuya; Ennio Carbone; Francesco Colucci
NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo.
The Journal of clinical investigation 2009;119(5):1251-63.
2009: Petter Brodin; Klas Kärre; Petter Höglund
NK cell education: not an on-off switch but a tunable rheostat.
Trends in immunology 2009;30(4):143-9.
2009: Petter Brodin; Tadepally Lakshmikanth; Sofia Johansson; Klas Kärre; Petter Höglund
The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells.
Blood 2009;113(11):2434-41.
2009: Michael Uhlin; Mantas Okas; Helen Karlsson; Jens Gertow; Lars Henningsohn; Olle Ringdén; Klas Kärre; Victor Levitsky; Jonas Mattsson
Increased frequency and responsiveness of PSA-specific T cells after allogeneic hematopoetic stem-cell transplantation.
Transplantation 2009;87(4):467-72.
2009: Sofia Johansson; Mali Salmon-Divon; MH Johansson; Yishai Pickman; Petter Brodin; Klas Kärre; Ramit Mehr; Petter Höglund
Probing natural killer cell education by Ly49 receptor expression analysis and computational modelling in single MHC class I mice.
PloS one 2009;4(6):e6046.
2009: Danika Schepis; Iva Gunnarsson; Maija-Leena Eloranta; Jon Lampa; Stefan H Jacobson; Klas Kärre; Louise Berg
Increased proportion of CD56bright natural killer cells in active and inactive systemic lupus erythematosus.
Immunology 2009;126(1):140-6.
2008: Klas Kärre
Natural killer cell recognition of missing self.
Nature immunology 2008;9(5):477-80.
2008: Kehmia Titanji; Stefano Sammicheli; Angelo De Milito; Paola Mantegani; Claudio Fortis; Louise Berg; Klas Kärre; Giovanna Travi; Chiara Tassandin; Lucia Lopalco; Bence Rethi; Giuseppe Tambussi; Francesca Chiodi
Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection.
Immunology 2008;123(2):164-70.
2007: Alain Townsend; Claes Ohlén; Judy Bastin; Hans-Gustaf Ljunggren; Linda Foster; Klas Kärre
Pillars article: Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 1989. 340: 443-448.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4301-6.
2007: Cristina Teixeira de Matos; Louise Berg; Jakob Michaëlsson; Li Felländer-Tsai; Klas Kärre; Kalle Söderström
Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion.
Immunology 2007;122(2):291-301.
2007: Y Sundström; C Nilsson; Gunnar Lilja; Klas Kärre; Marita Troye-Blomberg; Louise Berg
The expression of human natural killer cell receptors in early life.
Scandinavian journal of immunology 2007;66(2-3):335-44.
2007: Claudia S Wagner; Gerdt C Riise; Tomas Bergström; Klas Kärre; Ennio Carbone; Louise Berg
Increased expression of leukocyte Ig-like receptor-1 and activating role of UL18 in the response to cytomegalovirus infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3536-43.
2006: Anthony R French; Hanna Sjölin; Sungjin Kim; Rima Koka; Liping Yang; Deborah A Young; Cristina Cerboni; Elena Tomasello; Averil Ma; Eric Vivier; Klas Kärre; Wayne M Yokoyama
DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):4981-90.
2006: Hanna Sjölin; Scott H Robbins; Gilles Bessou; Asa S Hidmark; Elena Tomasello; Maria Johansson; Håkan Hall; Férose Charifi; Gunilla B Karlsson Hedestam; Christine A Biron; Klas Kärre; Petter Höglund; Eric Vivier; Marc Dalod
DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):2908-16.
2006: Thorbald van Hall; Elisabeth Z Wolpert; Peter van Veelen; Sandra Laban; Michael van der Veer; Marjet Roseboom; Sandra A Bres; Per Grufman; Arnoud de Ru; Hugo D Meiring; Annemieke de Jong; Kees L M C Franken; Antoinette Teixeira; Rob Valentijn; Jan Wouter Drijfhout; Frits Koning; Marcel Camps; Ferry Ossendorp; Klas Kärre; Hans-Gustaf Ljunggren; Cornelis J M Melief; Rienk Offringa
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants.
Nature medicine 2006;12(4):417-24.
2006: Cristina Cerboni; Adnane Achour; Anette Wärnmark; Mehrdad Mousavi-Jazi; Tatyana Sandalova; Mei-Ling Hsu; David Cosman; Klas Kärre; Ennio Carbone
Spontaneous mutations in the human CMV HLA class I homologue UL18 affect its binding to the inhibitory receptor LIR-1/ILT2/CD85j.
European journal of immunology 2006;36(3):732-41.
2006: Adnane Achour; Jakob Michaëlsson; Robert A Harris; Hans-Gustaf Ljunggren; Klas Kärre; Gunter Schneider; Tatyana Sandalova
Structural basis of the differential stability and receptor specificity of H-2Db in complex with murine versus human beta2-microglobulin.
Journal of molecular biology 2006;356(2):382-96.
2005: Tatyana Sandalova; Jakob Michaëlsson; Robert A Harris; Hans-Gustaf Ljunggren; Klas Kärre; Gunter Schneider; Adnane Achour
Expression, refolding and crystallization of murine MHC class I H-2Db in complex with human beta2-microglobulin.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 12):1090-3.
2005: Tatyana Sandalova; Jakob Michaëlsson; Robert A Harris; Jacob Odeberg; Gunter Schneider; Klas Kärre; Adnane Achour
A structural basis for CD8+ T cell-dependent recognition of non-homologous peptide ligands: implications for molecular mimicry in autoreactivity.
The Journal of biological chemistry 2005;280(29):27069-75.
2005: Klas Kärre; Hans-Gustaf Ljunggren; Gerald Piontek; Rolf Kiessling
Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. 1986.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):6566-9.
2005: Sofia Johansson; Maria Johansson; Eleftheria Rosmaraki; Gustaf Vahlne; Ramit Mehr; Mali Salmon-Divon; François Lemonnier; Klas Kärre; Petter Höglund
Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules.
The Journal of experimental medicine 2005;201(7):1145-55.
2004: Alexandre L R Oliveira; Sebastian Thams; Olle Lidman; Fredrik Piehl; Tomas Hökfelt; Klas Kärre; Hans Lindå; Staffan Cullheim
A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(51):17843-8.
2004: Linda Oberg; Sofia Johansson; Jakob Michaëlsson; Elena Tomasello; Eric Vivier; Klas Kärre; Petter Höglund
Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo - role of KARAP/DAP12-dependent and -independent pathways.
European journal of immunology 2004;34(6):1646-53.
2004: Cristina Cerboni; L Oberg; Giuseppe Terrazzano; Serafino Zappacosta; Ennio Carbone; Klas Kärre
Proliferative and cytotoxic response of human natural killer cells exposed to transporter associated with antigen-processing-deficient cells.
Scandinavian journal of immunology 2004;59(2):159-67.
2003: Alexander Rölle; Mehrdad Mousavi-Jazi; Mikael Eriksson; Jacob Odeberg; Cecilia Söderberg-Nauclér; David Cosman; Klas Kärre; Cristina Cerboni
Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):902-8.
2003: Petter Höglund; Klas Kärre; Georg Klein
The uterine cervix--a new member of the family of immunologically exceptional sites?
Cancer immunity 2003;3():6.
2003: Louise Berg; Gerdt C Riise; David Cosman; Tomas Bergström; Sigvard Olofsson; Klas Kärre; Ennio Carbone
LIR-1 expression on lymphocytes, and cytomegalovirus disease in lung-transplant recipients.
Lancet 2003;361(9363):1099-101.
2002: Jakob Michaëlsson; Cristina Teixeira de Matos; Adnane Achour; Lewis L Lanier; Klas Kärre; Kalle Söderström
A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.
The Journal of experimental medicine 2002;196(11):1403-14.
2002: Adnane Achour; Jakob Michaëlsson; Robert A Harris; Jacob Odeberg; Per Grufman; Johan K Sandberg; Victor Levitsky; Klas Kärre; Tatyana Sandalova; Gunter Schneider
A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses.
Immunity 2002;17(6):757-68.
2002: Klas Kärre
Clever, cleverer, cleverest.
Nature immunology 2002;3(6):505-6.
2002: Hanna Sjölin; Elena Tomasello; Mehrdad Mousavi-Jazi; Armando Bartolazzi; Klas Kärre; Eric Vivier; Cristina Cerboni
Pivotal role of KARAP/DAP12 adaptor molecule in the natural killer cell-mediated resistance to murine cytomegalovirus infection.
The Journal of experimental medicine 2002;195(7):825-34.
2002: Klas Kärre
Immunology. A perfect mismatch.
Science (New York, N.Y.) 2002;295(5562):2029-31.
2002: Klas Kärre
NK cells, MHC class I molecules and the missing self.
Scandinavian journal of immunology 2002;55(3):221-8.
2002: Jacob Odeberg; Cristina Cerboni; H Browne; Klas Kärre; Erna Möller; Ennio Carbone; Cecilia Söderberg-Nauclér
Human cytomegalovirus (HCMV)-infected endothelial cells and macrophages are less susceptible to natural killer lysis independent of the downregulation of classical HLA class I molecules or expression of the HCMV class I homologue, UL18.
Scandinavian journal of immunology 2002;55(2):149-61.
2002: M Waldenström; Adnane Achour; J Michaelsson; Alexander Rölle; Klas Kärre
The role of an exposed loop in the alpha2 domain in the mouse MHC class I H-2Dd molecule for recognition by the monoclonal antibody 34-5-8S and the NK-cell receptor Ly49A.
Scandinavian journal of immunology 2002;55(2):129-39.
2002: Jonas Sundbäck; Adnane Achour; Jakob Michaëlsson; Hannah Lindström; Klas Kärre
NK cell inhibitory receptor Ly-49C residues involved in MHC class I binding.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):793-800.
2001: A Sjöström; M Eriksson; Cristina Cerboni; MH Johansson; charles sentman; Klas Kärre; Petter Höglund
Acquisition of external major histocompatibility complex class I molecules by natural killer cells expressing inhibitory Ly49 receptors.
The Journal of experimental medicine 2001;194(10):1519-30.
2001: Cristina Cerboni; Mehrdad Mousavi-Jazi; H Wakiguchi; Ennio Carbone; Klas Kärre; Kalle Söderström
Synergistic effect of IFN-gamma and human cytomegalovirus protein UL40 in the HLA-E-dependent protection from NK cell-mediated cytotoxicity.
European journal of immunology 2001;31(10):2926-35.
2001: Jakob Michaëlsson; Adnane Achour; Alexander Rölle; Klas Kärre
MHC class I recognition by NK receptors in the Ly49 family is strongly influenced by the beta 2-microglobulin subunit.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7327-34.
2001: Taku Kambayashi; Jakob Michaëlsson; Linda Fahlén; Benedict J Chambers; charles sentman; Klas Kärre; Hans-Gustaf Ljunggren
Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro.
European journal of immunology 2001;31(3):869-75.
2000: J K Sandberg; Ann-Charlotte Boström; Claudia Devito; B Kohleisen; Volker Erfle; Adnane Achour; M Levi; S Schwartz; Klas Kärre; Britta Wahren; Jorma Hinkula
Human immunodeficiency virus type 1 Nef epitopes recognized in HLA-A2 transgenic mice in response to DNA and peptide immunization.
Virology 2000;273(1):112-9.
2000: Johan K Sandberg; L Franksson; Jonas Sundbäck; J Michaelsson; M Petersson; Adnane Achour; Robert P A Wallin; N E Sherman; T Bergman; H Jörnvall; D F Hunt; Rolf Kiessling; Klas Kärre
T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):25-33.
2000: Ennio Carbone; Giuseppe Terrazzano; A Melián; Delia Zanzi; L Moretta; Steven A Porcelli; Klas Kärre; Serafino Zappacosta
Inhibition of human NK cell-mediated killing by CD1 molecules.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6130-7.
2000: Cristina Cerboni; Mehrdad Mousavi-Jazi; A Linde; Kalle Söderström; Maria Brytting; Britta Wahren; Klas Kärre; Ennio Carbone
Human cytomegalovirus strain-dependent changes in NK cell recognition of infected fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4775-82.
2000: Per Grufman; Klas Kärre
Innate and adaptive immunity to tumors: IL-12 is required for optimal responses.
European journal of immunology 2000;30(4):1088-93.
2000: MH Johansson; Charles J Bieberich; A Kâse-Sjöström; T Yoshioka; E Höglund; Barbara Christy; G Scangos; Klas Kärre; G Jay; Petter Höglund
Differential effects on T cell and NK cell development by tissue-specific expression of H-2D(d) transgene.
European journal of immunology 2000;30(2):525-33.
2000: Rickard Glas; L Franksson; C Une; M L Eloranta; Claes Ohlén; Anders Orn; Klas Kärre
Recruitment and activation of natural killer (NK) cells in vivo determined by the target cell phenotype. An adaptive component of NK cell-mediated responses.
The Journal of experimental medicine 2000;191(1):129-38.
2000: Jakob Michaëlsson; Adnane Achour; M Salcedo; A Kâse-Sjöström; Jonas Sundbäck; Robert A Harris; Klas Kärre
Visualization of inhibitory Ly49 receptor specificity with soluble major histocompatibility complex class I tetramers.
European journal of immunology 2000;30(1):300-7.
1999: Ennio Carbone; Giuseppe Terrazzano; Giuseppina Ruggiero; Delia Zanzi; A Ottaiano; Clotilde Manzo; Klas Kärre; Serafino Zappacosta
Recognition of autologous dendritic cells by human NK cells.
European journal of immunology 1999;29(12):4022-9.
1999: L Franksson; Jonas Sundbäck; Adnane Achour; J Bernlind; Rickard Glas; Klas Kärre
Peptide dependency and selectivity of the NK cell inhibitory receptor Ly-49C.
European journal of immunology 1999;29(9):2748-58.
1999: Per Grufman; Johan K Sandberg; Elisabeth Z Wolpert; Klas Kärre
Immunization with dendritic cells breaks immunodominance in CTL responses against minor histocompatibility and synthetic peptide antigens.
Journal of leukocyte biology 1999;66(2):268-71.
1999: Per Grufman; Elisabeth Z Wolpert; Johan K Sandberg; Klas Kärre
T cell competition for the antigen-presenting cell as a model for immunodominance in the cytotoxic T lymphocyte response against minor histocompatibility antigens.
European journal of immunology 1999;29(7):2197-204.
1999: MY Olsson-Alheim; Jonas Sundbäck; Klas Kärre; charles sentman
The MHC class I molecule H-2Dp inhibits murine NK cells via the inhibitory receptor Ly49A.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7010-4.
1999: A Martín-Fontecha; Erika Assarsson; Ennio Carbone; Klas Kärre; Hans-Gustaf Ljunggren
Triggering of murine NK cells by CD40 and CD86 (B7-2).
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5910-6.
1999: Johan K Sandberg; Klas Kärre; Rickard Glas
Recognition of the major histocompatibility complex restriction element modulates CD8(+) T cell specificity and compensates for loss of T cell receptor contacts with the specific peptide.
The Journal of experimental medicine 1999;189(6):883-94.
1999: Adnane Achour; Robert A Harris; K Persson; Jonas Sundbäck; charles sentman; Gunter Schneider; Ylva Lindqvist; Klas Kärre
Murine class I major histocompatibility complex H-2Dd: expression, refolding and crystallization.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):260-2.
1998: A Kåse; MH Johansson; MY Olsson-Alheim; Klas Kärre; Petter Höglund
External and internal calibration of the MHC class I-specific receptor Ly49A on murine natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):6133-8.
1998: Elisabeth Z Wolpert; Per Grufman; Johan K Sandberg; A Tegnesjö; Klas Kärre
Immunodominance in the CTL response against minor histocompatibility antigens: interference between responding T cells, rather than with presentation of epitopes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4499-505.
1998: M Waldenström; Jonas Sundbäck; MY Olsson-Alheim; Adnane Achour; Klas Kärre
Impaired MHC class I (H-2Dd)-mediated protection against Ly-49A+ NK cells after amino acid substitutions in the antigen binding cleft.
European journal of immunology 1998;28(9):2872-81.
1998: Adnane Achour; K Persson; Robert A Harris; Jonas Sundbäck; charles sentman; Ylva Lindqvist; Gunter Schneider; Klas Kärre
The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition.
Immunity 1998;9(2):199-208.
1998: Jonas Sundbäck; Mary C Nakamura; M Waldenström; Eréne C Niemi; William Seaman; James C Ryan; Klas Kärre
The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):5971-8.
1998: Johan K Sandberg; Per Grufman; Elisabeth Z Wolpert; L Franksson; Benedict J Chambers; Klas Kärre
Superdominance among immunodominant H-2Kb-restricted epitopes and reversal by dendritic cell-mediated antigen delivery.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3163-9.
1998: Petter Höglund; Rickard Glas; C Ménard; A Kåse; MH Johansson; L Franksson; F Lemmonier; Klas Kärre
Beta2-microglobulin-deficient NK cells show increased sensitivity to MHC class I-mediated inhibition, but self tolerance does not depend upon target cell expression of H-2Kb and Db heavy chains.
European journal of immunology 1998;28(1):370-8.
1997: Elisabeth Z Wolpert; M Petersson; Benedict J Chambers; Johan K Sandberg; Rolf Kiessling; Hans-Gustaf Ljunggren; Klas Kärre
Generation of CD8+ T cells specific for transporter associated with antigen processing deficient cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11496-501.
1997: Flavio Salazar-Onfray; T Nakazawa; V Chhajlani; M Petersson; Klas Kärre; Giuseppe Masucci; E Celis; A Sette; S Southwood; E Appella; Rolf Kiessling
Synthetic peptides derived from the melanocyte-stimulating hormone receptor MC1R can stimulate HLA-A2-restricted cytotoxic T lymphocytes that recognize naturally processed peptides on human melanoma cells.
Cancer research 1997;57(19):4348-55.
1997: MY Olsson-Alheim; M Salcedo; Hans-Gustaf Ljunggren; Klas Kärre; charles sentman
NK cell receptor calibration: effects of MHC class I induction on killing by Ly49Ahigh and Ly49Alow NK cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3189-94.
1997: MH Johansson; Charles J Bieberich; G Jay; Klas Kärre; Petter Höglund
Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I transgene.
The Journal of experimental medicine 1997;186(3):353-64.
1997: Ennio Carbone; Giuseppina Ruggiero; Giuseppe Terrazzano; C Palomba; Clotilde Manzo; Silvia Fontana; H Spits; Klas Kärre; Serafino Zappacosta
A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction.
The Journal of experimental medicine 1997;185(12):2053-60.
1997: M Salcedo; Alexander Diehl; MY Olsson-Alheim; Jonas Sundbäck; L Van Kaer; Klas Kärre; Hans-Gustaf Ljunggren
Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3174-80.
1997: Petter Höglund; Jonas Sundbäck; MY Olsson-Alheim; M Johansson; M Salcedo; Claes Ohlén; Hans-Gustaf Ljunggren; charles sentman; Klas Kärre
Host MHC class I gene control of NK-cell specificity in the mouse.
Immunological reviews 1997;155():11-28.
1997: Klas Kärre
How to recognize a foreign submarine.
Immunological reviews 1997;155():5-9.
1997: Petter Höglund; MY Olsson-Alheim; M Johansson; Klas Kärre; charles sentman
Lack of F1 anti-parental resistance in H-2b/d F1 hybrids devoid of beta2-microglobulin.
European journal of immunology 1997;27(1):342-5.
1996: Jonas Sundbäck; Klas Kärre; charles sentman
Cloning of minimally divergent allelic forms of the natural killer (NK) receptor Ly-49C, differentially controlled by host genes in the MHC and NK gene complexes.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):3936-42.
1996: charles sentman; MY Olsson-Alheim; U Lendahl; Klas Kärre
Influence of glycosylphosphatidylinositol-linked H-2Dd molecules on target cell protection and natural killer cell specificity in transgenic mice.
European journal of immunology 1996;26(9):2127-32.
1996: Hans-Gustaf Ljunggren; Rickard Glas; Johan K Sandberg; Klas Kärre
Reactivity and specificity of CD8+ T cells in mice with defects in the MHC class I antigen-presenting pathway.
Immunological reviews 1996;151():123-48.
1996: charles sentman; MY Olsson-Alheim; U Lendahl; Klas Kärre
H-2Dp transgene alters natural killer cell specificity at the target and effector cell levels. Comparison with an H-2Dd transgene.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2423-9.
1996: Ennio Carbone; Giuseppe Terrazzano; Marco COLONna; Loretta Tuosto; Enza Piccolella; L Franksson; G Palazzolo; J J Pérez-Villar; S Fontana; Klas Kärre; Serafino Zappacosta
Natural killer clones recognize specific soluble HLA class I molecules.
European journal of immunology 1996;26(3):683-9.
1996: Johan K Sandberg; Benedict J Chambers; L Van Kaer; Klas Kärre; Hans-Gustaf Ljunggren
TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity.
European journal of immunology 1996;26(2):288-93.
1995: Flavio Salazar-Onfray; M Petersson; L Franksson; M Matsuda; Thomas Blankenstein; Klas Kärre; Rolf Kiessling
IL-10 converts mouse lymphoma cells to a CTL-resistant, NK-sensitive phenotype with low but peptide-inducible MHC class I expression.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(12):6291-8.
1995: Elisabeth Z Wolpert; L Franksson; Klas Kärre
Dominant and cryptic antigens in the MHC class I restricted T cell response across a complex minor histocompatibility barrier: analysis and mapping by elution of cellular peptides.
International immunology 1995;7(6):919-28.
1995: C Ohlén; Petter Höglund; charles sentman; Ennio Carbone; Hans-Gustaf Ljunggren; Beverly H Koller; Klas Kärre
Inhibition of natural killer cell-mediated bone marrow graft rejection by allogeneic major histocompatibility complex class I, but not class II molecules.
European journal of immunology 1995;25(5):1286-91.
1995: Rickard Glas; M Waldenström; Petter Höglund; George Klein; Klas Kärre; Hans-Gustaf Ljunggren
Rejection of tumors in mice with severe combined immunodeficiency syndrome determined by the major histocompatibility complex. Class I expression on the graft.
Cancer research 1995;55(9):1911-6.
1995: charles sentman; M Y Olsson; Klas Kärre
Missing self recognition by natural killer cells in MHC class I transgenic mice. A 'receptor calibration' model for how effector cells adapt to self.
Seminars in immunology 1995;7(2):109-19.
1995: M Y Olsson; Klas Kärre; charles sentman
Altered phenotype and function of natural killer cells expressing the major histocompatibility complex receptor Ly-49 in mice transgenic for its ligand.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1649-53.
1995: Klas Kärre
Express yourself or die: peptides, MHC molecules, and NK cells.
Science (New York, N.Y.) 1995;267(5200):978-9.
1994: G Stuber; G H Leder; W T Storkus; Michael T Lotze; Susanne Modrow; L Székely; Hans Wolf; Eva Klein; Klas Kärre; George Klein
Identification of wild-type and mutant p53 peptides binding to HLA-A2 assessed by a peptide loading-deficient cell line assay and a novel major histocompatibility complex class I peptide binding assay.
European journal of immunology 1994;24(3):765-8.
1994: Rickard Glas; C Ohlén; Petter Höglund; Klas Kärre
The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I.
The Journal of experimental medicine 1994;179(2):661-72.
1993: L Franksson; M Petersson; Rolf Kiessling; Klas Kärre
Immunization against tumor and minor histocompatibility antigens by eluted cellular peptides loaded on antigen processing defective cells.
European journal of immunology 1993;23(10):2606-13.
1993: Petter Höglund; M Waldenström; Klas Kärre
Role of major histocompatibility complex class I alpha 1/alpha 2 domain polymorphism and in vivo expression pattern in tumor resistance: studies with transgenic mice and lymphoma cell transfectants.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993;14(3):175-81.
1993: Ennio Carbone; G Stuber; S Andrée; L Franksson; Eva Klein; A Beretta; Antonio Siccardi; Klas Kärre
Reduced expression of major histocompatibility complex class I free heavy chains and enhanced sensitivity to natural killer cells after incubation of human lymphoid lines with beta 2-microglobulin.
European journal of immunology 1993;23(8):1752-6.
1993: Klas Kärre
Natural killer cells and the MHC class I pathway of peptide presentation.
Seminars in immunology 1993;5(2):127-45.
1993: L Franksson; E George; S Powis; G Butcher; J Howard; Klas Kärre
Tumorigenicity conferred to lymphoma mutant by major histocompatibility complex-encoded transporter gene.
The Journal of experimental medicine 1993;177(1):201-5.
1992: Rickard Glas; L Franksson; C Ohlén; Petter Höglund; Beverly H Koller; Hans-Gustaf Ljunggren; Klas Kärre
Major histocompatibility complex class I-specific and -restricted killing of beta 2-microglobulin-deficient cells by CD8+ cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11381-5.
1992: G Stuber; Susanne Modrow; Petter Höglund; L Franksson; J Elvin; Hans Wolf; Klas Kärre; George Klein
Assessment of major histocompatibility complex class I interaction with Epstein-Barr virus and human immunodeficiency virus peptides by elevation of membrane H-2 and HLA in peptide loading-deficient cells.
European journal of immunology 1992;22(10):2697-703.
1992: Rickard Glas; K Sturmhöfel; G J Hämmerling; Klas Kärre; Hans-Gustaf Ljunggren
Restoration of a tumorigenic phenotype by beta 2-microglobulin transfection to EL-4 mutant cells.
The Journal of experimental medicine 1992;175(3):843-6.
1991: Petter Höglund; C Ohlén; Ennio Carbone; L Franksson; Hans-Gustaf Ljunggren; A Latour; Beverly H Koller; Klas Kärre
Recognition of beta 2-microglobulin-negative (beta 2m-) T-cell blasts by natural killer cells from normal but not from beta 2m- mice: nonresponsiveness controlled by beta 2m- bone marrow in chimeric mice.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):10332-6.
1991: Fumie Aosai; C Ohlen; Hans-Gustaf Ljunggren; Petter Höglund; L Franksson; H Ploegh; A Townsend; Klas Kärre; Hans J Stauss
Different types of allospecific CTL clones identified by their ability to recognize peptide loading-defective target cells.
European journal of immunology 1991;21(11):2767-74.
1991: Klas Kärre
MHC gene control of the natural killer system at the level of the target and the host.
Seminars in cancer biology 1991;2(5):295-309.
1991: Petter Höglund; Rickard Glas; C Ohlén; Hans-Gustaf Ljunggren; Klas Kärre
Alteration of the natural killer repertoire in H-2 transgenic mice: specificity of rapid lymphoma cell clearance determined by the H-2 phenotype of the target.
The Journal of experimental medicine 1991;174(2):327-34.
1991: Hans-Gustaf Ljunggren; C Ohlén; Petter Höglund; L Franksson; Klas Kärre
The RMA-S lymphoma mutant; consequences of a peptide loading defect on immunological recognition and graft rejection.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1991;6():38-44.
1990: M Pérez; Ignacio Algarra; Hans-Gustaf Ljunggren; A Caballero; M J Mialdea; José Juan Gaforio; G Klein; Klas Kärre; Federico Garrido
A weakly tumorigenic phenotype with high MHC class-I expression is associated with high metastatic potential after surgical removal of the primary murine fibrosarcoma.
International journal of cancer. Journal international du cancer 1990;46(2):258-61.
1990: Hans-Gustaf Ljunggren; N J Stam; C Ohlén; Jacques Neefjes; Petter Höglund; M T Heemels; J Bastin; Schumacher Ton; A Townsend; Klas Kärre
Empty MHC class I molecules come out in the cold.
Nature 1990;346(6283):476-80.
1990: C Ohlén; J Bastin; Hans-Gustaf Ljunggren; Stefan Imreh; George Klein; A R Townsend; Klas Kärre
Restoration of H-2b expression and processing of endogenous antigens in the MHC class I pathway by fusion of a lymphoma mutant to L cells of the H-2k haplotype.
European journal of immunology 1990;20(8):1873-6.
1990: C Ohlén; J Bastin; Hans-Gustaf Ljunggren; L Foster; E Wolpert; George Klein; A R Townsend; Klas Kärre
Resistance to H-2-restricted but not to allo-H2-specific graft and cytotoxic T lymphocyte responses in lymphoma mutant.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):52-8.
1990: Hans-Gustaf Ljunggren; K Sturmhöfel; E Wolpert; G J Hämmerling; Klas Kärre
Transfection of beta 2-microglobulin restores IFN-mediated protection from natural killer cell lysis in YAC-1 lymphoma variants.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):380-6.
1990: Petter Höglund; Hans-Gustaf Ljunggren; Klas Kärre; G Jay
Role of major histocompatibility complex class-I molecules in tumor rejection. New insights from studies with synthetic peptides and transgenic mice.
Immunologic research 1990;9(4):298-313.
1989: C Ohlén; G Kling; Petter Höglund; M Hansson; G Scangos; Charles J Bieberich; G Jay; Klas Kärre
Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice.
Science (New York, N.Y.) 1989;246(4930):666-8.
1989: Ignacio Algarra; C Ohlén; M Perez; Hans-Gustaf Ljunggren; G Klein; Federico Garrido; Klas Kärre
NK sensitivity and lung clearance of MHC-class-I-deficient cells within a heterogeneous fibrosarcoma.
International journal of cancer. Journal international du cancer 1989;44(4):675-80.
1989: L Tsai; C Ohlén; Hans-Gustaf Ljunggren; Klas Kärre; M Hansson; Rolf Kiessling
Effect of IFN-gamma treatment and in vivo passage of murine tumor cell lines on their sensitivity to lymphokine-activated killer (LAK) cell lysis in vitro; association with H-2 expression on the target cells.
International journal of cancer. Journal international du cancer 1989;44(4):669-74.
1989: A Townsend; C Ohlén; J Bastin; Hans-Gustaf Ljunggren; L Foster; Klas Kärre
Association of class I major histocompatibility heavy and light chains induced by viral peptides.
Nature 1989;340(6233):443-8.
1989: T Yamasaki; Hans-Gustaf Ljunggren; C Ohlén; George Klein; Klas Kärre
Enhanced H-2 expression and T-cell-dependent rejection after intracerebral transplantation of the murine lymphoma YAC-1.
Cellular immunology 1989;120(2):387-95.
1989: C Ohlén; Maria Teresa Bejarano; A Grönberg; S Torsteinsdottir; L Franksson; Hans-Gustaf Ljunggren; Eva Klein; George Klein; Klas Kärre
Studies of sublines selected for loss of HLA expression from an EBV-transformed lymphoblastoid cell line. Changes in sensitivity to cytotoxic T cells activated by allostimulation and natural killer cells activated by IFN or IL-2.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(9):3336-41.
1989: Hans-Gustaf Ljunggren; S Pääbo; M Cochet; G Kling; P Kourilsky; Klas Kärre
Molecular analysis of H-2-deficient lymphoma lines. Distinct defects in biosynthesis and association of MHC class I heavy chains and beta 2-microglobulin observed in cells with increased sensitivity to NK cell lysis.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(8):2911-7.
1989: A Townsend; C Ohlën; L Foster; J Bastin; Hans-Gustaf Ljunggren; Klas Kärre
A mutant cell in which association of class I heavy and light chains is induced by viral peptides.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():299-308.
1988: Petter Höglund; Hans-Gustaf Ljunggren; C Ohlén; Lars Ahrlund-Richter; G Scangos; Charles J Bieberich; G Jay; George Klein; Klas Kärre
Natural resistance against lymphoma grafts conveyed by H-2Dd transgene to C57BL mice.
The Journal of experimental medicine 1988;168(4):1469-74.
1988: T Yamasaki; George Klein; Hans-Gustaf Ljunggren; Petter Höglund; C Ohlén; M G Petersson; Klas Kärre
Effects of dimethyl sulfoxide treatment on H-2 expression and susceptibility to NK- or cytotoxic T-lymphocyte-mediated lysis of the YAC-1 lymphoma and its beta 2-microglobulin-deficient variant.
Journal of the National Cancer Institute 1988;80(4):263-9.
1988: Hans-Gustaf Ljunggren; T Yamasaki; P Collins; George Klein; Klas Kärre
Selective acceptance of MHC class I-deficient tumor grafts in the brain.
The Journal of experimental medicine 1988;167(2):730-5.
1988: Hans-Gustaf Ljunggren; C Ohlén; Petter Höglund; T Yamasaki; George Klein; Klas Kärre
Afferent and efferent cellular interactions in natural resistance directed against MHC class I deficient tumor grafts.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(2):671-8.
1978: George Klein; Gunnar Klein; Klas Kärre; R Kiessling
'Hybrid resistance' against parental tumors: One or several genetic patterns?
Immunogenetics 1978;7(1):391-404.