Klas Kärre

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Thams Sebastian; Brodin Petter; Plantman Stefan; Saxelin Robert; Kärre Klas; Cullheim Staffan
Classical major histocompatibility complex class I molecules in motoneurons: new actors at the neuromuscular junction.
Schepis D; D'Amato M; Studahl M; Bergström T; Kärre K; Berg L
Herpes simplex virus infection downmodulates NKG2D ligand expression.
Lakshmikanth Tadepally; Burke Shannon; Ali Talib Hassan; Kimpfler Silvia; Ursini Francesco; Ruggeri Loredana; Capanni Marusca; Umansky Viktor; Paschen Annette; Sucker Antje; Pende Daniela; Groh Veronika; Biassoni Roberto; Höglund Petter; Kato Masashi; Shibuya Kazuko; Schadendorf Dirk; Anichini Andrea; Ferrone Soldano; Velardi Andrea; Kärre Klas; Shibuya Akira; Carbone Ennio; Colucci Francesco
NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo.

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All Publications

2009: Thams Sebastian; Brodin Petter; Plantman Stefan; Saxelin Robert; Kärre Klas; Cullheim Staffan
Classical major histocompatibility complex class I molecules in motoneurons: new actors at the neuromuscular junction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(43):13503-15.
2009: Schepis D; D'Amato M; Studahl M; Bergström T; Kärre K; Berg L
Herpes simplex virus infection downmodulates NKG2D ligand expression.
Scandinavian journal of immunology 2009;69(5):429-36.
2009: Lakshmikanth Tadepally; Burke Shannon; Ali Talib Hassan; Kimpfler Silvia; Ursini Francesco; Ruggeri Loredana; Capanni Marusca; Umansky Viktor; Paschen Annette; Sucker Antje; Pende Daniela; Groh Veronika; Biassoni Roberto; Höglund Petter; Kato Masashi; Shibuya Kazuko; Schadendorf Dirk; Anichini Andrea; Ferrone Soldano; Velardi Andrea; Kärre Klas; Shibuya Akira; Carbone Ennio; Colucci Francesco
NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo.
The Journal of clinical investigation 2009;119(5):1251-63.
2009: Brodin Petter; Kärre Klas; Höglund Petter
NK cell education: not an on-off switch but a tunable rheostat.
Trends in immunology 2009;30(4):143-9.
2009: Brodin Petter; Lakshmikanth Tadepally; Johansson Sofia; Kärre Klas; Höglund Petter
The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells.
Blood 2009;113(11):2434-41.
2009: Uhlin Michael; Okas Mantas; Karlsson Helen; Gertow Jens; Henningsohn Lars; Ringdén Olle; Kärre Klas; Levitsky Victor; Mattsson Jonas
Increased frequency and responsiveness of PSA-specific T cells after allogeneic hematopoetic stem-cell transplantation.
Transplantation 2009;87(4):467-72.
2009: Schepis Danika; Gunnarsson Iva; Eloranta Maija-Leena; Lampa Jon; Jacobson Stefan H; Kärre Klas; Berg Louise
Increased proportion of CD56bright natural killer cells in active and inactive systemic lupus erythematosus.
Immunology 2009;126(1):140-6.
2009: Johansson Sofia; Salmon-Divon Mali; Johansson Maria H; Pickman Yishai; Brodin Petter; Kärre Klas; Mehr Ramit; Höglund Petter
Probing natural killer cell education by Ly49 receptor expression analysis and computational modelling in single MHC class I mice.
PloS one 2009;4(6):e6046.
2008: Kärre Klas
Natural killer cell recognition of missing self.
Nature immunology 2008;9(5):477-80.
2008: Titanji Kehmia; Sammicheli Stefano; De Milito Angelo; Mantegani Paola; Fortis Claudio; Berg Louise; Kärre Klas; Travi Giovanna; Tassandin Chiara; Lopalco Lucia; Rethi Bence; Tambussi Giuseppe; Chiodi Francesca
Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection.
Immunology 2008;123(2):164-70.
2007: Townsend Alain; Ohlén Claes; Bastin Judy; Ljunggren Hans-Gustaf; Foster Linda; Kärre Klas
Pillars article: Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 1989. 340: 443-448.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4301-6.
2007: de Matos Cristina Teixeira; Berg Louise; Michaëlsson Jakob; Felländer-Tsai Li; Kärre Klas; Söderström Kalle
Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion.
Immunology 2007;122(2):291-301.
2007: Sundström Y; Nilsson C; Lilja G; Kärre K; Troye-Blomberg M; Berg L
The expression of human natural killer cell receptors in early life.
Scandinavian journal of immunology 2007;66(2-3):335-44.
2007: Wagner Claudia S; Riise Gerdt C; Bergström Tomas; Kärre Klas; Carbone Ennio; Berg Louise
Increased expression of leukocyte Ig-like receptor-1 and activating role of UL18 in the response to cytomegalovirus infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3536-43.
2006: French Anthony R; Sjölin Hanna; Kim Sungjin; Koka Rima; Yang Liping; Young Deborah A; Cerboni Cristina; Tomasello Elena; Ma Averil; Vivier Eric; Kärre Klas; Yokoyama Wayne M
DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):4981-90.
2006: Sjölin Hanna; Robbins Scott H; Bessou Gilles; Hidmark Asa; Tomasello Elena; Johansson Maria; Hall Håkan; Charifi Férose; Karlsson Hedestam Gunilla B; Biron Christine A; Kärre Klas; Höglund Petter; Vivier Eric; Dalod Marc
DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):2908-16.
2006: van Hall Thorbald; Wolpert Elisabeth Z; van Veelen Peter; Laban Sandra; van der Veer Michael; Roseboom Marjet; Bres Sandra; Grufman Per; de Ru Arnoud; Meiring Hugo; de Jong Ad; Franken Kees; Teixeira Antoinette; Valentijn Rob; Drijfhout Jan Wouter; Koning Frits; Camps Marcel; Ossendorp Ferry; Kärre Klas; Ljunggren Hans-Gustaf; Melief Cornelis J M; Offringa Rienk
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants.
Nature medicine 2006;12(4):417-24.
2006: Cerboni Cristina; Achour Adnane; Wärnmark Anette; Mousavi-Jazi Mehrdad; Sandalova Tatyana; Hsu Mei-Ling; Cosman David; Kärre Klas; Carbone Ennio
Spontaneous mutations in the human CMV HLA class I homologue UL18 affect its binding to the inhibitory receptor LIR-1/ILT2/CD85j.
European journal of immunology 2006;36(3):732-41.
2006: Achour Adnane; Michaëlsson Jakob; Harris Robert A; Ljunggren Hans-Gustaf; Kärre Klas; Schneider Gunter; Sandalova Tatyana
Structural basis of the differential stability and receptor specificity of H-2Db in complex with murine versus human beta2-microglobulin.
Journal of molecular biology 2006;356(2):382-96.
2005: Sandalova Tatyana; Michaëlsson Jakob; Harris Robert A; Ljunggren Hans-Gustaf; Kärre Klas; Schneider Gunter; Achour Adnane
Expression, refolding and crystallization of murine MHC class I H-2Db in complex with human beta2-microglobulin.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 12):1090-3.
2005: Sandalova Tatyana; Michaëlsson Jakob; Harris Robert A; Odeberg Jacob; Schneider Gunter; Kärre Klas; Achour Adnane
A structural basis for CD8+ T cell-dependent recognition of non-homologous peptide ligands: implications for molecular mimicry in autoreactivity.
The Journal of biological chemistry 2005;280(29):27069-75.
2005: Kärre Klas; Ljunggren Hans Gustaf; Piontek Gerald; Kiessling Rolf
Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. 1986.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):6566-9.
2005: Johansson Sofia; Johansson Maria; Rosmaraki Eleftheria; Vahlne Gustaf; Mehr Ramit; Salmon-Divon Mali; Lemonnier François; Kärre Klas; Höglund Petter
Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules.
The Journal of experimental medicine 2005;201(7):1145-55.
2004: Oliveira Alexandre L R; Thams Sebastian; Lidman Olle; Piehl Fredrik; Hökfelt Tomas; Kärre Klas; Lindå Hans; Cullheim Staffan
A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(51):17843-8.
2004: Oberg Linda; Johansson Sofia; Michaëlsson Jakob; Tomasello Elena; Vivier Eric; Kärre Klas; Höglund Petter
Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo - role of KARAP/DAP12-dependent and -independent pathways.
European journal of immunology 2004;34(6):1646-53.
2004: Cerboni C; Oberg L; Terrazzano G; Zappacosta S; Carbone E; Kärre K
Proliferative and cytotoxic response of human natural killer cells exposed to transporter associated with antigen-processing-deficient cells.
Scandinavian journal of immunology 2004;59(2):159-67.
2003: Rölle Alexander; Mousavi-Jazi Mehrdad; Eriksson Mikael; Odeberg Jenny; Söderberg-Nauclér Cecilia; Cosman David; Kärre Klas; Cerboni Cristina
Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):902-8.
2003: Höglund Petter; Kärre Klas; Klein Georg
The uterine cervix--a new member of the family of immunologically exceptional sites?
Cancer immunity : a journal of the Academy of Cancer Immunology 2003;3():6.
2003: Berg Louise; Riise Gerdt C; Cosman David; Bergström Tomas; Olofsson Sigvard; Kärre Klas; Carbone Ennio
LIR-1 expression on lymphocytes, and cytomegalovirus disease in lung-transplant recipients.
Lancet 2003;361(9363):1099-101.
2002: Achour Adnane; Michaëlsson Jakob; Harris Robert A; Odeberg Jacob; Grufman Per; Sandberg Johan K; Levitsky Victor; Kärre Klas; Sandalova Tatyana; Schneider Gunter
A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses.
Immunity 2002;17(6):757-68.
2002: Michaëlsson Jakob; Teixeira de Matos Cristina; Achour Adnane; Lanier Lewis L; Kärre Klas; Söderström Kalle
A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.
The Journal of experimental medicine 2002;196(11):1403-14.
2002: Kärre Klas
Clever, cleverer, cleverest.
Nature immunology 2002;3(6):505-6.
2002: Sjölin Hanna; Tomasello Elena; Mousavi-Jazi Mehrdad; Bartolazzi Armando; Kärre Klas; Vivier Eric; Cerboni Cristina
Pivotal role of KARAP/DAP12 adaptor molecule in the natural killer cell-mediated resistance to murine cytomegalovirus infection.
The Journal of experimental medicine 2002;195(7):825-34.
2002: Kärre K
NK cells, MHC class I molecules and the missing self.
Scandinavian journal of immunology 2002;55(3):221-8.
2002: Kärre Klas
Immunology. A perfect mismatch.
Science (New York, N.Y.) 2002;295(5562):2029-31.
2002: Odeberg J; Cerboni C; Browne H; Kärre K; Möller E; Carbone E; Söderberg-Nauclér C
Human cytomegalovirus (HCMV)-infected endothelial cells and macrophages are less susceptible to natural killer lysis independent of the downregulation of classical HLA class I molecules or expression of the HCMV class I homologue, UL18.
Scandinavian journal of immunology 2002;55(2):149-61.
2002: Waldenström M; Achour A; Michaelsson J; Rölle A; Kärre K
The role of an exposed loop in the alpha2 domain in the mouse MHC class I H-2Dd molecule for recognition by the monoclonal antibody 34-5-8S and the NK-cell receptor Ly49A.
Scandinavian journal of immunology 2002;55(2):129-39.
2002: Sundbäck Jonas; Achour Adnane; Michaëlsson Jakob; Lindström Hannah; Kärre Klas
NK cell inhibitory receptor Ly-49C residues involved in MHC class I binding.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):793-800.
2001: Sjöström A; Eriksson M; Cerboni C; Johansson M H; Sentman C L; Kärre K; Höglund P
Acquisition of external major histocompatibility complex class I molecules by natural killer cells expressing inhibitory Ly49 receptors.
The Journal of experimental medicine 2001;194(10):1519-30.
2001: Cerboni C; Mousavi-Jazi M; Wakiguchi H; Carbone E; Kärre K; Söderström K
Synergistic effect of IFN-gamma and human cytomegalovirus protein UL40 in the HLA-E-dependent protection from NK cell-mediated cytotoxicity.
European journal of immunology 2001;31(10):2926-35.
2001: Michaëlsson J; Achour A; Rölle A; Kärre K
MHC class I recognition by NK receptors in the Ly49 family is strongly influenced by the beta 2-microglobulin subunit.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7327-34.
2001: Kambayashi T; Michaëlsson J; Fahlén L; Chambers B J; Sentman C L; Kärre K; Ljunggren H G
Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro.
European journal of immunology 2001;31(3):869-75.
2000: Sandberg J K; Leandersson A C; Devito C; Kohleisen B; Erfle V; Achour A; Levi M; Schwartz S; Kärre K; Wahren B; Hinkula J
Human immunodeficiency virus type 1 Nef epitopes recognized in HLA-A2 transgenic mice in response to DNA and peptide immunization.
Virology 2000;273(1):112-9.
2000: Sandberg J K; Franksson L; Sundbäck J; Michaelsson J; Petersson M; Achour A; Wallin R P; Sherman N E; Bergman T; Jörnvall H; Hunt D F; Kiessling R; Kärre K
T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):25-33.
2000: Carbone E; Terrazzano G; Melián A; Zanzi D; Moretta L; Porcelli S; Kärre K; Zappacosta S
Inhibition of human NK cell-mediated killing by CD1 molecules.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6130-7.
2000: Cerboni C; Mousavi-Jazi M; Linde A; Söderström K; Brytting M; Wahren B; Kärre K; Carbone E
Human cytomegalovirus strain-dependent changes in NK cell recognition of infected fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4775-82.
2000: Grufman P; Kärre K
Innate and adaptive immunity to tumors: IL-12 is required for optimal responses.
European journal of immunology 2000;30(4):1088-93.
2000: Johansson M H; Bieberich C; Kâse-Sjöström A; Yoshioka T; Höglund E; Christy B A; Scangos G; Kärre K; Jay G; Höglund P
Differential effects on T cell and NK cell development by tissue-specific expression of H-2D(d) transgene.
European journal of immunology 2000;30(2):525-33.
2000: Glas R; Franksson L; Une C; Eloranta M L; Ohlén C; Orn A; Kärre K
Recruitment and activation of natural killer (NK) cells in vivo determined by the target cell phenotype. An adaptive component of NK cell-mediated responses.
The Journal of experimental medicine 2000;191(1):129-38.
2000: Michaëlsson J; Achour A; Salcedo M; Kâse-Sjöström A; Sundbäck J; Harris R A; Kärre K
Visualization of inhibitory Ly49 receptor specificity with soluble major histocompatibility complex class I tetramers.
European journal of immunology 2000;30(1):300-7.
1999: Carbone E; Terrazzano G; Ruggiero G; Zanzi D; Ottaiano A; Manzo C; Kärre K; Zappacosta S
Recognition of autologous dendritic cells by human NK cells.
European journal of immunology 1999;29(12):4022-9.
1999: Franksson L; Sundbäck J; Achour A; Bernlind J; Glas R; Kärre K
Peptide dependency and selectivity of the NK cell inhibitory receptor Ly-49C.
European journal of immunology 1999;29(9):2748-58.
1999: Grufman P; Sandberg J K; Wolpert E Z; Kärre K
Immunization with dendritic cells breaks immunodominance in CTL responses against minor histocompatibility and synthetic peptide antigens.
Journal of leukocyte biology 1999;66(2):268-71.
1999: Grufman P; Wolpert E Z; Sandberg J K; Kärre K
T cell competition for the antigen-presenting cell as a model for immunodominance in the cytotoxic T lymphocyte response against minor histocompatibility antigens.
European journal of immunology 1999;29(7):2197-204.
1999: Olsson-Alheim M Y; Sundbäck J; Kärre K; Sentman C L
The MHC class I molecule H-2Dp inhibits murine NK cells via the inhibitory receptor Ly49A.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7010-4.
1999: Martín-Fontecha A; Assarsson E; Carbone E; Kärre K; Ljunggren H G
Triggering of murine NK cells by CD40 and CD86 (B7-2).
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5910-6.
1999: Sandberg J K; Kärre K; Glas R
Recognition of the major histocompatibility complex restriction element modulates CD8(+) T cell specificity and compensates for loss of T cell receptor contacts with the specific peptide.
The Journal of experimental medicine 1999;189(6):883-94.
1999: Achour A; Harris R A; Persson K; Sundbäck J; Sentman C L; Schneider G; Lindqvist Y; Kärre K
Murine class I major histocompatibility complex H-2Dd: expression, refolding and crystallization.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):260-2.
1998: Kåse A; Johansson M H; Olsson-Alheim M Y; Kärre K; Höglund P
External and internal calibration of the MHC class I-specific receptor Ly49A on murine natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):6133-8.
1998: Wolpert E Z; Grufman P; Sandberg J K; Tegnesjö A; Kärre K
Immunodominance in the CTL response against minor histocompatibility antigens: interference between responding T cells, rather than with presentation of epitopes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4499-505.
1998: Waldenström M; Sundbäck J; Olsson-Alheim M Y; Achour A; Kärre K
Impaired MHC class I (H-2Dd)-mediated protection against Ly-49A+ NK cells after amino acid substitutions in the antigen binding cleft.
European journal of immunology 1998;28(9):2872-81.
1998: Achour A; Persson K; Harris R A; Sundbäck J; Sentman C L; Lindqvist Y; Schneider G; Kärre K
The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition.
Immunity 1998;9(2):199-208.
1998: Sundbäck J; Nakamura M C; Waldenström M; Niemi E C; Seaman W E; Ryan J C; Kärre K
The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):5971-8.
1998: Sandberg J K; Grufman P; Wolpert E Z; Franksson L; Chambers B J; Kärre K
Superdominance among immunodominant H-2Kb-restricted epitopes and reversal by dendritic cell-mediated antigen delivery.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3163-9.
1998: Höglund P; Glas R; Ménard C; Kåse A; Johansson M H; Franksson L; Lemmonier F; Kärre K
Beta2-microglobulin-deficient NK cells show increased sensitivity to MHC class I-mediated inhibition, but self tolerance does not depend upon target cell expression of H-2Kb and Db heavy chains.
European journal of immunology 1998;28(1):370-8.
1997: Salazar-Onfray F; Nakazawa T; Chhajlani V; Petersson M; Kärre K; Masucci G; Celis E; Sette A; Southwood S; Appella E; Kiessling R
Synthetic peptides derived from the melanocyte-stimulating hormone receptor MC1R can stimulate HLA-A2-restricted cytotoxic T lymphocytes that recognize naturally processed peptides on human melanoma cells.
Cancer research 1997;57(19):4348-55.
1997: Wolpert E Z; Petersson M; Chambers B J; Sandberg J K; Kiessling R; Ljunggren H G; Kärre K
Generation of CD8+ T cells specific for transporter associated with antigen processing deficient cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11496-501.
1997: Olsson-Alheim M Y; Salcedo M; Ljunggren H G; Kärre K; Sentman C L
NK cell receptor calibration: effects of MHC class I induction on killing by Ly49Ahigh and Ly49Alow NK cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3189-94.
1997: Johansson M H; Bieberich C; Jay G; Kärre K; Höglund P
Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I transgene.
The Journal of experimental medicine 1997;186(3):353-64.
1997: Carbone E; Ruggiero G; Terrazzano G; Palomba C; Manzo C; Fontana S; Spits H; Kärre K; Zappacosta S
A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction.
The Journal of experimental medicine 1997;185(12):2053-60.
1997: Salcedo M; Diehl A D; Olsson-Alheim M Y; Sundbäck J; Van Kaer L; Kärre K; Ljunggren H G
Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3174-80.
1997: Höglund P; Sundbäck J; Olsson-Alheim M Y; Johansson M; Salcedo M; Ohlén C; Ljunggren H G; Sentman C L; Kärre K
Host MHC class I gene control of NK-cell specificity in the mouse.
Immunological reviews 1997;155():11-28.
1997: Kärre K
How to recognize a foreign submarine.
Immunological reviews 1997;155():5-9.
1997: Höglund P; Olsson-Alheim M Y; Johansson M; Kärre K; Sentman C L
Lack of F1 anti-parental resistance in H-2b/d F1 hybrids devoid of beta2-microglobulin.
European journal of immunology 1997;27(1):342-5.
1996: Sundbäck J; Kärre K; Sentman C L
Cloning of minimally divergent allelic forms of the natural killer (NK) receptor Ly-49C, differentially controlled by host genes in the MHC and NK gene complexes.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):3936-42.
1996: Sentman C L; Olsson-Alheim M Y; Lendahl U; Kärre K
Influence of glycosylphosphatidylinositol-linked H-2Dd molecules on target cell protection and natural killer cell specificity in transgenic mice.
European journal of immunology 1996;26(9):2127-32.
1996: Ljunggren H G; Glas R; Sandberg J K; Kärre K
Reactivity and specificity of CD8+ T cells in mice with defects in the MHC class I antigen-presenting pathway.
Immunological reviews 1996;151():123-48.
1996: Sentman C L; Olsson-Alheim M Y; Lendahl U; Kärre K
H-2Dp transgene alters natural killer cell specificity at the target and effector cell levels. Comparison with an H-2Dd transgene.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2423-9.
1996: Carbone E; Terrazzano G; Colonna M; Tuosto L; Piccolella E; Franksson L; Palazzolo G; Pérez-Villar J J; Fontana S; Kärre K; Zappacosta S
Natural killer clones recognize specific soluble HLA class I molecules.
European journal of immunology 1996;26(3):683-9.
1996: Sandberg J K; Chambers B J; Van Kaer L; Kärre K; Ljunggren H G
TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity.
European journal of immunology 1996;26(2):288-93.
1995: Salazar-Onfray F; Petersson M; Franksson L; Matsuda M; Blankenstein T; Kärre K; Kiessling R
IL-10 converts mouse lymphoma cells to a CTL-resistant, NK-sensitive phenotype with low but peptide-inducible MHC class I expression.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(12):6291-8.
1995: Wolpert E; Franksson L; Kärre K
Dominant and cryptic antigens in the MHC class I restricted T cell response across a complex minor histocompatibility barrier: analysis and mapping by elution of cellular peptides.
International immunology 1995;7(6):919-28.
1995: Ohlén C; Höglund P; Sentman C L; Carbone E; Ljunggren H G; Koller B; Kärre K
Inhibition of natural killer cell-mediated bone marrow graft rejection by allogeneic major histocompatibility complex class I, but not class II molecules.
European journal of immunology 1995;25(5):1286-91.
1995: Glas R; Waldenström M; Höglund P; Klein G; Kärre K; Ljunggren H G
Rejection of tumors in mice with severe combined immunodeficiency syndrome determined by the major histocompatibility complex. Class I expression on the graft.
Cancer research 1995;55(9):1911-6.
1995: Sentman C L; Olsson M Y; Kärre K
Missing self recognition by natural killer cells in MHC class I transgenic mice. A 'receptor calibration' model for how effector cells adapt to self.
Seminars in immunology 1995;7(2):109-19.
1995: Olsson M Y; Kärre K; Sentman C L
Altered phenotype and function of natural killer cells expressing the major histocompatibility complex receptor Ly-49 in mice transgenic for its ligand.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1649-53.
1995: Kärre K
Express yourself or die: peptides, MHC molecules, and NK cells.
Science (New York, N.Y.) 1995;267(5200):978-9.
1994: Stuber G; Leder G H; Storkus W T; Lotze M T; Modrow S; Székely L; Wolf H; Klein E; Kärre K; Klein G
Identification of wild-type and mutant p53 peptides binding to HLA-A2 assessed by a peptide loading-deficient cell line assay and a novel major histocompatibility complex class I peptide binding assay.
European journal of immunology 1994;24(3):765-8.
1994: Glas R; Ohlén C; Höglund P; Kärre K
The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I.
The Journal of experimental medicine 1994;179(2):661-72.
1993: Franksson L; Petersson M; Kiessling R; Kärre K
Immunization against tumor and minor histocompatibility antigens by eluted cellular peptides loaded on antigen processing defective cells.
European journal of immunology 1993;23(10):2606-13.
1993: Höglund P; Waldenström M; Kärre K
Role of major histocompatibility complex class I alpha 1/alpha 2 domain polymorphism and in vivo expression pattern in tumor resistance: studies with transgenic mice and lymphoma cell transfectants.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993;14(3):175-81.
1993: Carbone E; Stuber G; Andrée S; Franksson L; Klein E; Beretta A; Siccardi A G; Kärre K
Reduced expression of major histocompatibility complex class I free heavy chains and enhanced sensitivity to natural killer cells after incubation of human lymphoid lines with beta 2-microglobulin.
European journal of immunology 1993;23(8):1752-6.
1993: Kärre K
Natural killer cells and the MHC class I pathway of peptide presentation.
Seminars in immunology 1993;5(2):127-45.
1993: Franksson L; George E; Powis S; Butcher G; Howard J; Kärre K
Tumorigenicity conferred to lymphoma mutant by major histocompatibility complex-encoded transporter gene.
The Journal of experimental medicine 1993;177(1):201-5.
1992: Glas R; Franksson L; Ohlén C; Höglund P; Koller B; Ljunggren H G; Kärre K
Major histocompatibility complex class I-specific and -restricted killing of beta 2-microglobulin-deficient cells by CD8+ cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11381-5.
1992: Stuber G; Modrow S; Höglund P; Franksson L; Elvin J; Wolf H; Kärre K; Klein G
Assessment of major histocompatibility complex class I interaction with Epstein-Barr virus and human immunodeficiency virus peptides by elevation of membrane H-2 and HLA in peptide loading-deficient cells.
European journal of immunology 1992;22(10):2697-703.
1992: Glas R; Sturmhöfel K; Hämmerling G J; Kärre K; Ljunggren H G
Restoration of a tumorigenic phenotype by beta 2-microglobulin transfection to EL-4 mutant cells.
The Journal of experimental medicine 1992;175(3):843-6.
1991: Höglund P; Ohlén C; Carbone E; Franksson L; Ljunggren H G; Latour A; Koller B; Kärre K
Recognition of beta 2-microglobulin-negative (beta 2m-) T-cell blasts by natural killer cells from normal but not from beta 2m- mice: nonresponsiveness controlled by beta 2m- bone marrow in chimeric mice.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):10332-6.
1991: Aosai F; Ohlen C; Ljunggren H G; Höglund P; Franksson L; Ploegh H; Townsend A; Kärre K; Stauss H J
Different types of allospecific CTL clones identified by their ability to recognize peptide loading-defective target cells.
European journal of immunology 1991;21(11):2767-74.
1991: Kärre K
MHC gene control of the natural killer system at the level of the target and the host.
Seminars in cancer biology 1991;2(5):295-309.
1991: Höglund P; Glas R; Ohlén C; Ljunggren H G; Kärre K
Alteration of the natural killer repertoire in H-2 transgenic mice: specificity of rapid lymphoma cell clearance determined by the H-2 phenotype of the target.
The Journal of experimental medicine 1991;174(2):327-34.
1991: Ljunggren H G; Ohlén C; Höglund P; Franksson L; Kärre K
The RMA-S lymphoma mutant; consequences of a peptide loading defect on immunological recognition and graft rejection.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1991;6():38-44.
1990: Ljunggren H G; Stam N J; Ohlén C; Neefjes J J; Höglund P; Heemels M T; Bastin J; Schumacher T N; Townsend A; Kärre K
Empty MHC class I molecules come out in the cold.
Nature 1990;346(6283):476-80.
1990: Ohlén C; Bastin J; Ljunggren H G; Imreh S; Klein G; Townsend A R; Kärre K
Restoration of H-2b expression and processing of endogenous antigens in the MHC class I pathway by fusion of a lymphoma mutant to L cells of the H-2k haplotype.
European journal of immunology 1990;20(8):1873-6.
1990: Pérez M; Algarra I; Ljunggren H G; Caballero A; Mialdea M J; Gaforio J J; Klein G; Kärre K; Garrido F
A weakly tumorigenic phenotype with high MHC class-I expression is associated with high metastatic potential after surgical removal of the primary murine fibrosarcoma.
International journal of cancer. Journal international du cancer 1990;46(2):258-61.
1990: Ohlén C; Bastin J; Ljunggren H G; Foster L; Wolpert E; Klein G; Townsend A R; Kärre K
Resistance to H-2-restricted but not to allo-H2-specific graft and cytotoxic T lymphocyte responses in lymphoma mutant.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):52-8.
1990: Ljunggren H G; Sturmhöfel K; Wolpert E; Hämmerling G J; Kärre K
Transfection of beta 2-microglobulin restores IFN-mediated protection from natural killer cell lysis in YAC-1 lymphoma variants.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):380-6.
1990: Höglund P; Ljunggren H G; Kärre K; Jay G
Role of major histocompatibility complex class-I molecules in tumor rejection. New insights from studies with synthetic peptides and transgenic mice.
Immunologic research 1990;9(4):298-313.
1989: Ohlén C; Kling G; Höglund P; Hansson M; Scangos G; Bieberich C; Jay G; Kärre K
Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice.
Science (New York, N.Y.) 1989;246(4930):666-8.
1989: Algarra I; Ohlén C; Perez M; Ljunggren H G; Klein G; Garrido F; Kärre K
NK sensitivity and lung clearance of MHC-class-I-deficient cells within a heterogeneous fibrosarcoma.
International journal of cancer. Journal international du cancer 1989;44(4):675-80.
1989: Tsai L; Ohlén C; Ljunggren H G; Kärre K; Hansson M; Kiessling R
Effect of IFN-gamma treatment and in vivo passage of murine tumor cell lines on their sensitivity to lymphokine-activated killer (LAK) cell lysis in vitro; association with H-2 expression on the target cells.
International journal of cancer. Journal international du cancer 1989;44(4):669-74.
1989: Townsend A; Ohlén C; Bastin J; Ljunggren H G; Foster L; Kärre K
Association of class I major histocompatibility heavy and light chains induced by viral peptides.
Nature 1989;340(6233):443-8.
1989: Yamasaki T; Ljunggren H G; Ohlén C; Klein G; Kärre K
Enhanced H-2 expression and T-cell-dependent rejection after intracerebral transplantation of the murine lymphoma YAC-1.
Cellular immunology 1989;120(2):387-95.
1989: Ohlén C; Bejarano M T; Grönberg A; Torsteinsdottir S; Franksson L; Ljunggren H G; Klein E; Klein G; Kärre K
Studies of sublines selected for loss of HLA expression from an EBV-transformed lymphoblastoid cell line. Changes in sensitivity to cytotoxic T cells activated by allostimulation and natural killer cells activated by IFN or IL-2.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(9):3336-41.
1989: Ljunggren H G; Pääbo S; Cochet M; Kling G; Kourilsky P; Kärre K
Molecular analysis of H-2-deficient lymphoma lines. Distinct defects in biosynthesis and association of MHC class I heavy chains and beta 2-microglobulin observed in cells with increased sensitivity to NK cell lysis.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(8):2911-7.
1989: Townsend A; Ohlën C; Foster L; Bastin J; Ljunggren H G; Kärre K
A mutant cell in which association of class I heavy and light chains is induced by viral peptides.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():299-308.
1988: Höglund P; Ljunggren H G; Ohlén C; Ahrlund-Richter L; Scangos G; Bieberich C; Jay G; Klein G; Kärre K
Natural resistance against lymphoma grafts conveyed by H-2Dd transgene to C57BL mice.
The Journal of experimental medicine 1988;168(4):1469-74.
1988: Yamasaki T; Klein G; Ljunggren H G; Höglund P; Ohlén C; Petersson M G; Kärre K
Effects of dimethyl sulfoxide treatment on H-2 expression and susceptibility to NK- or cytotoxic T-lymphocyte-mediated lysis of the YAC-1 lymphoma and its beta 2-microglobulin-deficient variant.
Journal of the National Cancer Institute 1988;80(4):263-9.
1988: Ljunggren H G; Yamasaki T; Collins P; Klein G; Kärre K
Selective acceptance of MHC class I-deficient tumor grafts in the brain.
The Journal of experimental medicine 1988;167(2):730-5.
1988: Ljunggren H G; Ohlén C; Höglund P; Yamasaki T; Klein G; Kärre K
Afferent and efferent cellular interactions in natural resistance directed against MHC class I deficient tumor grafts.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(2):671-8.

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