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Gerard Karsenty

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Mathieu Ferron; Andrea Ballabio; Shigeaki Kato; Julie Lacombe; David J Rawlings; Carmine Settembre; Junko Shimazu; Gerard Karsenty
A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts.
Tiffany Zee; Munevver P Makinistoglu; Jan P Tuckermann; Sören Boller; Rudolf Grosschedl; Ildiko Györy; Gerard Karsenty
The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner.
Yoko Yamamoto; Tatsuya Yoshizawa; Taiyong Yu; Ken-Ichi Aihara; Pierre Chambon; Toru Fukuda; Maiko Hoshino; Erina Inoue; Kazuki Inoue; Gerard Karsenty; Shigeaki Kato; Hirotaka Kawano; Daniel Metzger; Yuko Nakamichi; Takashi Sato; Keisuke Sekine; Masayo Shindo; Yuko Shirode-Fukuda; Naoya Tsuji; Tomoyuki Watanabe; Yuuki Imai
Vitamin D receptor in osteoblasts is a negative regulator of bone mass control.

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2013: Mathieu Ferron; Andrea Ballabio; Shigeaki Kato; Julie Lacombe; David J Rawlings; Carmine Settembre; Junko Shimazu; Gerard Karsenty
A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts.
Genes & development 2013;27(8):955-69.
2013: Tiffany Zee; Munevver P Makinistoglu; Jan P Tuckermann; Sören Boller; Rudolf Grosschedl; Ildiko Györy; Gerard Karsenty
The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner.
FEBS letters 2013;587(6):711-6.
2013: Yoko Yamamoto; Tatsuya Yoshizawa; Taiyong Yu; Ken-Ichi Aihara; Pierre Chambon; Toru Fukuda; Maiko Hoshino; Erina Inoue; Kazuki Inoue; Gerard Karsenty; Shigeaki Kato; Hirotaka Kawano; Daniel Metzger; Yuko Nakamichi; Takashi Sato; Keisuke Sekine; Masayo Shindo; Yuko Shirode-Fukuda; Naoya Tsuji; Tomoyuki Watanabe; Yuuki Imai
Vitamin D receptor in osteoblasts is a negative regulator of bone mass control.
Endocrinology 2013;154(3):1008-20.
2013: Emilio Arteaga-Solis; Charles W Emala; Charles Vinson; Jürgen Wess; Tiffany Zee; Gerard Karsenty
Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma.
Cell metabolism 2013;17(1):35-48.
2013: Takashi Watanabe; Maki Asada; Daisuke Harada; Masayo Inagawa; Yoshiaki Ito; Gerard Karsenty; Ken-ichi Katsube; Motoo Kitagawa; Toshihisa Komori; Toshinao Oyama; Sumio Sugano; Yutaka Suzuki; Hiroshi Asahara
MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development.
PLoS genetics 2013;9(1):e1003132.
2012: Gerard Karsenty
Tribute to L. J. Henderson, a remarkable physiologist, and the founder of the American School of Sociology (1878-1942).
American journal of physiology. Cell physiology 2012;303(10):C1001-3.
2012: Grzegorz Sumara; Olga Sumara; Jason K Kim; Gerard Karsenty
Gut-derived serotonin is a multifunctional determinant to fasting adaptation.
Cell metabolism 2012;16(5):588-600.
2012: Jianwen Wei; Lihua Zheng; Bin Zhou; Yu Shi; Ji Wang; Rudolf Grosschedl; X Edward Guo; Hiroyuki Inose; Gerard Karsenty
miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2.
The Journal of cell biology 2012;197(4):509-21.
2012: Ryo Hanyu; Tadayoshi Hayata; Hiroaki Hemmi; Kazuo Kaneko; Gerard Karsenty; Henry M Kronenberg; Hisashi Kurosawa; Shuichi Moriya; M Nagao; Tetsuya Nakamoto; Takuya Notomi; Yoshitomo Saita; Ernestina Schipani; Shu Takeda; Jean-Pierre Vilardaga; Vanessa L Wehbi; Yoichi Ezura; Timothy N Feinstein; Masaki Noda
Anabolic action of parathyroid hormone regulated by the β2-adrenergic receptor.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(19):7433-8.
2012: Gerard Karsenty
The mutual dependence between bone and gonads.
The Journal of endocrinology 2012;213(2):107-14.
2012: Emilio Arteaga-Solis; Andrea Ballabio; Carmine Settembre; Gerard Karsenty
Sulfatases are determinants of alveolar formation.
Matrix biology : journal of the International Society for Matrix Biology 2012;31(4):253-60.
2012: Jane Palsgaard; Grzegorz Sumara; Jonathon N Winnay; Brice Emanuelli; Gerard Karsenty; C Ronald Kahn
Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5).
The Journal of biological chemistry 2012;287(15):12016-26.
2012: Carmine Settembre; Michel C Vellard; Francesco Vetrini; Roberto Zoncu; Serkan Erdin; SerpilUckac Erdin; Valeria Facchinetti; Mathieu Ferron; Tuong Huynh; Gerard Karsenty; Diego L Medina; David M Sabatini; Andrea Ballabio
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
The EMBO journal 2012;31(5):1095-108.
2012: Tiffany Zee; Robert L Levine; Carmine Settembre; Gerard Karsenty
T-cell protein tyrosine phosphatase regulates bone resorption and whole-body insulin sensitivity through its expression in osteoblasts.
Molecular and cellular biology 2012;32(6):1080-8.
2012: Clifford Rosen; Gerard Karsenty; Ormond A MacDougald
Foreword: interactions between bone and adipose tissue and metabolism.
Bone 2012;50(2):429.
2012: Gerard Karsenty; Franck Oury
Biology without walls: the novel endocrinology of bone.
Annual review of physiology 2012;74():87-105.
2011: Masashi Nagao; Tetsuya Nakamoto; Takuya Notomi; Susan Rittling; Yoshitomo Saita; Shu Takeda; Jean-Pierre Vilardaga; Kathryn Wang; David T Denhardt; Yoichi Ezura; Timothy N Feinstein; Ryo Hanyu; Tadayoshi Hayata; Hiroaki Hemmi; Yayoi Izu; Kazuo Kaneko; Gerard Karsenty; Hisashi Kurosawa; Masaki Noda
Sympathetic control of bone mass regulated by osteopontin.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(43):17767-72.
2011: Gerard Karsenty
Bone endocrine regulation of energy metabolism and male reproduction.
Comptes rendus biologies 2011;334(10):720-4.
2011: Hiroyuki Inose; Gerard Karsenty; Vijay Yadav; Bin Zhou; X Edward Guo; Patricia Ducy
Efficacy of serotonin inhibition in mouse models of bone loss.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(9):2002-11.
2011: Franck Oury; Gerard Karsenty
Towards a serotonin-dependent leptin roadmap in the brain.
Trends in endocrinology and metabolism: TEM 2011;22(9):382-7.
2011: Gerard Karsenty; Michael D Gershon
The importance of the gastrointestinal tract in the control of bone mass accrual.
Gastroenterology 2011;141(2):439-42.
2011: Daisuke Kajimura; Eiichi Hinoi; Mathieu Ferron; Aruna Kode; Kyle J Riley; Bin Zhou; X Edward Guo; Gerard Karsenty
Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrual.
The Journal of experimental medicine 2011;208(4):841-51.
2011: Thomas Landes Clemens; Gerard Karsenty
The osteoblast: an insulin target cell controlling glucose homeostasis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(4):677-80.
2011: Franck Oury; Grzegorz Sumara; Olga Sumara; Mathieu Ferron; Haixin Chang; Charles E Smith; Louis Hermo; Susan Suarez; Bryan L Roth; Patricia Ducy; Gerard Karsenty
Endocrine regulation of male fertility by the skeleton.
Cell 2011;144(5):796-809.
2011: Vijay K Yadav; Franck Oury; Kenji F Tanaka; Kenji Tanaka; Tiffany Thomas; Ying Wang; Serge Cremers; Rene Hen; Andree Krust; Pierre Chambon; Gerard Karsenty
Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications.
The Journal of experimental medicine 2011;208(1):41-52.
2011: Gerard Karsenty; Vijay K Yadav
Regulation of bone mass by serotonin: molecular biology and therapeutic implications.
Annual review of medicine 2011;62():323-31.
2010: Gerard Karsenty; Franck Oury
The central regulation of bone mass, the first link between bone remodeling and energy metabolism.
The Journal of clinical endocrinology and metabolism 2010;95(11):4795-801.
2010: Franck Oury; Vijay K Yadav; Ying Wang; Bin Zhou; X Sherry Liu; X Edward Guo; Laurence H Tecott; Günther Schutz; Anthony R Means; Gerard Karsenty
CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons.
Genes & development 2010;24(20):2330-42.
2010: Patricia Ducy; Gerard Karsenty
The two faces of serotonin in bone biology.
The Journal of cell biology 2010;191(1):7-13.
2010: Harikiran Nistala; Sui Lee-Arteaga; Silvia Smaldone; Gabriella Siciliano; Luca Carta; Robert N Ono; Gerhard Sengle; Emilio Arteaga-Solis; Regis Levasseur; Patricia Ducy; Lynn Y Sakai; Gerard Karsenty; Francesco Ramirez
Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.
The Journal of cell biology 2010;190(6):1107-21.
2010: Mathieu Ferron; Jianwen Wei; Tatsuya Yoshizawa; Andrea Del Fattore; Ronald A DePinho; Anna Teti; Patricia Ducy; Gerard Karsenty
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism.
Cell 2010;142(2):296-308.
2010: Mathieu Ferron; Jianwen Wei; Tatsuya Yoshizawa; Patricia Ducy; Gerard Karsenty
An ELISA-based method to quantify osteocalcin carboxylation in mice.
Biochemical and biophysical research communications 2010;397(4):691-6.
2010: Yu Shi; Franck Oury; Vijay K Yadav; Jürgen Wess; X Sherry Liu; X Edward Guo; Monzur Murshed; Gerard Karsenty
Signaling through the M(3) muscarinic receptor favors bone mass accrual by decreasing sympathetic activity.
Cell metabolism 2010;11(3):231-8.
2010: Morten Frost; Tom Erenskjold Andersen; Vijay Yadav; Kim Brixen; Gerard Karsenty; Moustapha Kassem
Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010;25(3):673-5.
2010: Vijay K Yadav; Santhanam Balaji; Padmanaban S Suresh; X Sherry Liu; Xin Lu; Zhishan Li; X Edward Guo; J John Mann; Anil K Balapure; Michael D Gershon; Rudraiah Medhamurthy; Marc Vidal; Gerard Karsenty; Patricia Ducy
Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis.
Nature medicine 2010;16(3):308-12.
2010: Charlene S Simmonds; Gerard Karsenty; Andrew C Karaplis; Christopher S Kovacs
Parathyroid hormone regulates fetal-placental mineral homeostasis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010;25(3):594-605.
2010: Marie-Therese Rached; Aruna Kode; Barbara C Silva; Dae Young Jung; Susan Gray; Helena Ong; Ji-Hye Paik; Ronald A DePinho; Jason K Kim; Gerard Karsenty; Stavroula Kousteni
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice.
The Journal of clinical investigation 2010;120(1):357-68.
2009: Vijay K Yadav; Gerard Karsenty
Leptin-dependent co-regulation of bone and energy metabolism.
Aging 2009;1(11):954-6.
2009: Cyrille B Confavreux; Robert L Levine; Gerard Karsenty
A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms.
Molecular and cellular endocrinology 2009;310(1-2):21-9.
2009: Vijay Yadav; Franck Oury; Nina Suda; Zhong-Wu Liu; Xiao-Bing Gao; Cyrille Confavreux; Kristen C Klemenhagen; Kenji F Tanaka; Jay A Gingrich; X Edward Guo; Laurence H Tecott; J John Mann; Rene Hen; Tamas L Horvath; Gerard Karsenty
A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.
Cell 2009;138(5):976-89.
2009: Eiichi Hinoi; Nan Gao; Dae Young Jung; Vijay Yadav; Tatsuya Yoshizawa; Daisuke Kajimura; Martin G Myers Jr; Streamson Chua Jr.; Qin Wang; Jason K Kim; Klaus H Kaestner; Gerard Karsenty
An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion.
Annals of the New York Academy of Sciences 2009;1173 Suppl 1():E20-30.
2009: Gerard Karsenty
Integrative physiology. Preface.
Annals of the New York Academy of Sciences 2009;1173 Suppl 1():E1.
2009: Tatsuya Yoshizawa; Eiichi Hinoi; Dae Young Jung; Daisuke Kajimura; Mathieu Ferron; Jin Seo; Jonathan M Graff; Jason K Kim; Gerard Karsenty
The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts.
The Journal of clinical investigation 2009;119(9):2807-17.
2009: Mathieu Ferron; Gerard Karsenty
The gutsy side of bone.
Cell metabolism 2009;10(1):7-8.
2009: Sumin Kang; Shannon Elf; Shaozhong Dong; Taro Hitosugi; Katherine Lythgoe; Ailan Guo; Hong Ruan; Sagar Lonial; Hanna J Khoury; Ifor Williams; Benjamin H Lee; Johannes L Roesel; Gerard Karsenty; André Hanauer; Jack Taunton; Titus Boggon; Ting-Lei Gu; Jing Chen
Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation.
Molecular and cellular biology 2009;29(8):2105-17.
2009: Carmine Settembre; Emilio Arteaga-Solis; Andrea Ballabio; Gerard Karsenty
Self-eating in skeletal development: implications for lysosomal storage disorders.
Autophagy 2009;5(2):228-9.
2009: Gerard Karsenty; Henry M Kronenberg; Carmine Settembre
Genetic control of bone formation.
Annual review of cell and developmental biology 2009;25():629-48.
2008: Eiichi Hinoi; Nan Gao; Dae Young Jung; Vijay Yadav; Tatsuya Yoshizawa; Martin G Myers Jr; Streamson Chua Jr.; Jason K Kim; Klaus kaestner; Gerard Karsenty
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity.
The Journal of cell biology 2008;183(7):1235-42.
2008: Vijay Yadav; Je-Hwang Ryu; Nina Suda; Kenji F Tanaka; Jay A Gingrich; Günther Schütz; Francis H Glorieux; Cherie Y Chiang; Jeffrey D Zajac; Karl L Insogna; J John Mann; René Hen; Patricia Ducy; Gerard Karsenty
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum.
Cell 2008;135(5):825-37.
2008: Carmine Settembre; Emilio Arteaga-Solis; Marc McKee; Raquel de Pablo; Qais Al-Awqati; Andrea Ballabio; Gerard Karsenty
Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification.
Genes & development 2008;22(19):2645-50.
2008: Shingo Sato; Ayako Kimura; Jerfi Ozdemir; Yoshinori Asou; Makiko Miyazaki; Tetsuya Jinno; Keisuke Ae; Xiuyun Liu; Mitsuhiko Osaki; Yasuhiro Takeuchi; Seiji Fukumoto; Hiroshi Kawaguchi; Hirotaka Haro; Kenichi Shinomiya; Gerard Karsenty; Shu Takeda
The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: findings in murine models and in human disease.
Arthritis and rheumatism 2008;58(9):2764-75.
2008: Manvendra Singh; Florent Elefteriou; Gerard Karsenty
Cocaine and amphetamine-regulated transcript may regulate bone remodeling as a circulating molecule.
Endocrinology 2008;149(8):3933-41.
2008: Na Kyung Lee; Gerard Karsenty
Reciprocal regulation of bone and energy metabolism.
Trends in endocrinology and metabolism: TEM 2008;19(5):161-6.
2008: Shu Takeda; Gerard Karsenty
Molecular bases of the sympathetic regulation of bone mass.
Bone 2008;42(5):837-40.
2008: Mathieu Ferron; Eiichi Hinoi; Gerard Karsenty; Patricia Ducy
Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(13):5266-70.
2008: Gerard Karsenty
Transcriptional control of skeletogenesis.
Annual review of genomics and human genetics 2008;9():183-96.
2007: Na Kyung Lee; Hideaki Sowa; Eiichi Hinoi; Mathieu Ferron; Jong Deok Ahn; Cyrille Confavreux; Romain Dacquin; Patrick J Mee; Marc McKee; Dae Young Jung; Zhiyou Zhang; Jason K Kim; Franck Mauvais-Jarvis; Patricia Ducy; Gerard Karsenty
Endocrine regulation of energy metabolism by the skeleton.
Cell 2007;130(3):456-69.
2007: Lihua Zheng; Hwa-Jin Baek; Gerard Karsenty; Monica J Justice
Filamin B represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner.
The Journal of cell biology 2007;178(1):121-8.
2007: Donald A Glass; Gerard Karsenty
In vivo analysis of Wnt signaling in bone.
Endocrinology 2007;148(6):2630-4.
2007: Kiyoshi Hiramatsu; Yutaro Asaba; Sunao Takeshita; Yuji Nimura; Sawako Tatsumi; Nobuyoshi Katagiri; Shumpei Niida; Toshihiro Nakajima; Sakae Tanaka; Masako Ito; Gerard Karsenty; Kyoji Ikeda
Overexpression of gamma-glutamyltransferase in transgenic mice accelerates bone resorption and causes osteoporosis.
Endocrinology 2007;148(6):2708-15.
2007: Mari T Kaartinen; Monzur Murshed; Gerard Karsenty; Marc McKee
Osteopontin upregulation and polymerization by transglutaminase 2 in calcified arteries of Matrix Gla protein-deficient mice.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007;55(4):375-86.
2007: Muriel Roulet; Florence Ruggiero; Gerard Karsenty; Dominique LeGuellec
A comprehensive study of the spatial and temporal expression of the col5a1 gene in mouse embryos: a clue for understanding collagen V function in developing connective tissues.
Cell and tissue research 2007;327(2):323-32.
2006: Florent Elefteriou; M Douglas Benson; Hideaki Sowa; Michael Starbuck; Xiuyun Liu; David Ron; Luis F Parada; Gerard Karsenty
ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae.
Cell metabolism 2006;4(6):441-51.
2006: Gerard Karsenty
Convergence between bone and energy homeostases: leptin regulation of bone mass.
Cell metabolism 2006;4(5):341-8.
2006: Eiichi Hinoi; Peter Bialek; You-Tzung Chen; Marie-Therese Rached; Yoram Groner; Richard R Behringer; David M Ornitz; Gerard Karsenty
Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium.
Genes & development 2006;20(21):2937-42.
2006: Satoru Kamekura; Yosuke Kawasaki; Kazuto Hoshi; Takashi Shimoaka; Hirotaka Chikuda; Zenjiro Maruyama; Toshihisa Komori; Shingo Sato; Shu Takeda; Gerard Karsenty; Kozo Nakamura; Ung-il Chung; Hiroshi Kawaguchi
Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.
Arthritis and rheumatism 2006;54(8):2462-70.
2006: Jong Deok Ahn; Beatrice Dubern; Cecile Lubrano-Berthelier; Karine Clement; Gerard Karsenty
Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency.
Endocrinology 2006;147(7):3196-202.
2006: Gergana Dobreva; Maria Chahrour; Marcel Dautzenberg; Laura Chirivella; Benoît Kanzler; Isabel Fariñas; Gerard Karsenty; Rudolf Grosschedl
SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.
Cell 2006;125(5):971-86.
2006: Monte M Winslow; Minggui Pan; Michael Starbuck; Elena M Gallo; Lei Deng; Gerard Karsenty; Gerald R Crabtree
Calcineurin/NFAT signaling in osteoblasts regulates bone mass.
Developmental cell 2006;10(6):771-82.
2006: Atif Zaheer; Monzur Murshed; Alec M De Grand; Timothy G Morgan; Gerard Karsenty; John V Frangioni
Optical imaging of hydroxyapatite in the calcified vasculature of transgenic animals.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(5):1132-6.
2006: Donald A Glass; Gerard Karsenty
Canonical Wnt signaling in osteoblasts is required for osteoclast differentiation.
Annals of the New York Academy of Sciences 2006;1068():117-30.
2006: Gerard Karsenty; Patricia Ducy
The hypothalamic control of bone mass, implication for the treatment of osteoporosis.
Annales d'endocrinologie 2006;67(2):123.
2006: Jun Guo; Ung-il Chung; Dehong Yang; Gerard Karsenty; F Richard Bringhurst; Henry M Kronenberg
PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways.
Developmental biology 2006;292(1):116-28.
2006: Xueying Wang; Hui-Yi Kua; Yuanyu Hu; Ke Guo; Qi Zeng; Qiang Wu; Huck-Hui Ng; Gerard Karsenty; Benoit de Crombrugghe; James Yeh; Baojie Li
p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling.
The Journal of cell biology 2006;172(1):115-25.
2006: Loning Fu; Millan S Patel; Gerard Karsenty
The circadian modulation of leptin-controlled bone formation.
Progress in brain research 2006;153():177-88.
2006: Donald A Glass; Gerard Karsenty
Molecular bases of the regulation of bone remodeling by the canonical Wnt signaling pathway.
Current topics in developmental biology 2006;73():43-84.
2005: Ivan Lobov; Sujata Rao; Thomas J. Carroll; Jefferson E Vallance; Masataka Ito; Jennifer K Ondr; Savita Kurup; Donald A Glass; Millan S Patel; Weiguo Shu; Edward Morrisey; Andrew P McMahon; Gerard Karsenty; Richard Lang
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature.
Nature 2005;437(7057):417-21.
2005: Loning Fu; Millan S Patel; Allan Bradley; Erwin F Wagner; Gerard Karsenty
The molecular clock mediates leptin-regulated bone formation.
Cell 2005;122(5):803-15.
2005: Guozhi Xiao; Di Jiang; Chunxi Ge; Zhuoran Zhao; Yumei Lai; Heidi Boules; Mattabhorn Phimphilai; xiangli yang; Gerard Karsenty; Renny Franceschi
Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression.
The Journal of biological chemistry 2005;280(35):30689-96.
2005: Hisataka Kondo; Akira Nifuji; Shu Takeda; Yoichi Ezura; Susan R Rittling; David T Denhardt; Kazuhisa Nakashima; Gerard Karsenty; Masaki Noda
Unloading induces osteoblastic cell suppression and osteoclastic cell activation to lead to bone loss via sympathetic nervous system.
The Journal of biological chemistry 2005;280(34):30192-200.
2005: Gerard Karsenty
An aggrecanase and osteoarthritis.
The New England journal of medicine 2005;353(5):522-3.
2005: Karine Clément; Gerard Karsenty
[Neural control of bone remodeling: crucial role of leptin].
Médecine sciences : M/S 2005;21(8-9):681-2.
2005: Ling Li; Ji Zhu; Qisheng Tu; Masato Yamauchi; Jaro Sodek; Gerard Karsenty; Jean Tang; Jake Chen
An in vivo model to study osteogenic gene regulation: targeting an avian retroviral receptor (TVA) to bone with the bone sialoprotein (BSP) promoter.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(8):1403-13.
2005: Akio Sakamoto; Min Chen; Takashi Nakamura; Tao Xie; Gerard Karsenty; Lee S Weinstein
Deficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical bone.
The Journal of biological chemistry 2005;280(22):21369-75.
2005: Donald A Glass; Peter Bialek; Jong Deok Ahn; Michael Starbuck; Millan S Patel; Hans Clevers; Mark M Taketo; Fanxin Long; Andrew P McMahon; Richard Lang; Gerard Karsenty
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.
Developmental cell 2005;8(5):751-64.
2005: Monzur Murshed; Dympna Harmey; José Luis Millán; Marc McKee; Gerard Karsenty
Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone.
Genes & development 2005;19(9):1093-104.
2005: Florent Elefteriou; Jong Deok Ahn; Shu Takeda; Michael Starbuck; xiangli yang; Xiuyun Liu; Hisataka Kondo; William G Richards; Tony W Bannon; Masaki Noda; Karine Clement; Christian Vaisse; Gerard Karsenty
Leptin regulation of bone resorption by the sympathetic nervous system and CART.
Nature 2005;434(7032):514-20.
2005: Kenneth R Chien; Gerard Karsenty
Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone.
Cell 2005;120(4):533-44.
2004: Francesca Giacopelli; Renato Marciano; Angela Pistorio; Paolo Catarsi; Silvana Canini; Gerard Karsenty; Roberto Ravazzolo
Polymorphisms in the osteopontin promoter affect its transcriptional activity.
Physiological genomics 2004;20(1):87-96.
2004: Rick B Vega; Koichi Matsuda; Junyoung Oh; Ana C Barbosa; xiangli yang; Eric Meadows; John McAnally; Chris Pomajzl; John M Shelton; James A Richardson; Gerard Karsenty; Eric N Olson
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis.
Cell 2004;119(4):555-66.
2004: xiangli yang; Gerard Karsenty
ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells.
The Journal of biological chemistry 2004;279(45):47109-14.
2004: Terrie-Anne Cock; Jonathan Back; Florent Elefteriou; Gerard Karsenty; Philippe Kastner; Susan Chan; Johan Auwerx
Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen.
EMBO reports 2004;5(10):1007-12.
2004: Catherine M Gordon; Laura K Bachrach; Thomas O Carpenter; Gerard Karsenty; Frank Rauch
Bone health in children and adolescents: a symposium at the annual meeting of the Pediatric Academic Societies/Lawson Wilkins Pediatric Endocrine Society, May 2003.
Current problems in pediatric and adolescent health care 2004;34(6):226-42.
2004: WenFang Wang; You-Gan Wang; Anthony M Reginato; Donald J Glotzer; Naomi Fukai; Sofiya Plotkina; Gerard Karsenty; Bjorn R Olsen
Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice.
Developmental biology 2004;270(2):364-81.
2004: Monzur Murshed; Thorsten Schinke; Marc McKee; Gerard Karsenty
Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins.
The Journal of cell biology 2004;165(5):625-30.
2004: xiangli yang; Koichi Matsuda; Peter Bialek; Sylvie Jacquot; Howard C Masuoka; Thorsten Schinke; Lingzhen Li; Stefano Brancorsini; Paolo Sassone-Corsi; Tim M Townes; André Hanauer; Gerard Karsenty
ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome.
Cell 2004;117(3):387-98.
2004: Florent Elefteriou; Gerard Karsenty
[Bone mass regulation by leptin: a hypothalamic control of bone formation].
Pathologie-biologie 2004;52(3):148-53.
2004: Romain Dacquin; Patrick J Mee; Jitsutaro Kawaguchi; Alan Davis; J A Gallagher; J Nichols; K Lee; Gerard Karsenty; A Smith
Knock-in of nuclear localised beta-galactosidase reveals that the tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collar.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;229(4):826-34.
2004: Florent Elefteriou; Shu Takeda; K Ebihara; J Magre; N Patano; C Ae Kim; Y Ogawa; Xiuyun Liu; Stephanie M Ware; William J Craigen; J J Robert; C Vinson; K Nakao; J Capeau; Gerard Karsenty
Serum leptin level is a regulator of bone mass.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3258-63.
2004: Peter Bialek; Britt Kern; xiangli yang; Marijke Schrock; Drazen Sosic; Nancy Hong; Hua Wu; Kai Yu; David M Ornitz; Eric N Olson; Monica J Justice; Gerard Karsenty
A twist code determines the onset of osteoblast differentiation.
Developmental cell 2004;6(3):423-35.
2004: Romain Dacquin; Rachel A Davey; Catherine Laplace; Regis Levasseur; Howard A Morris; Steven R Goldring; Samuel Gebre-Medhin; Deborah L Galson; Jeffrey D Zajac; Gerard Karsenty
Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo.
The Journal of cell biology 2004;164(4):509-14.
2004: You-Tzung Chen; Regis Levasseur; Sukeshi Vaishnav; Gerard Karsenty; Allan Bradley
Bigenic Cre/loxP, puDeltatk conditional genetic ablation.
Nucleic acids research 2004;32(20):e161.
2004: Yunxia Cui; Lu Huang; Florent Elefteriou; Guoqing Yang; John M Shelton; Jerald E Giles; Orhan K Oz; Tiffany Pourbahrami; Christopher Y H Lu; James A Richardson; Gerard Karsenty; Cai Li
Essential role of STAT3 in body weight and glucose homeostasis.
Molecular and cellular biology 2004;24(1):258-69.
2003: Donald A Glass; Millan S Patel; Gerard Karsenty
A new insight into the formation of osteolytic lesions in multiple myeloma.
The New England journal of medicine 2003;349(26):2479-80.
2003: Florent Elefteriou; Shu Takeda; Xiuyun Liu; Dawna Armstrong; Gerard Karsenty
Monosodium glutamate-sensitive hypothalamic neurons contribute to the control of bone mass.
Endocrinology 2003;144(9):3842-7.
2003: Sunhwa Kim; Takako Koga; Miho Isobe; Britt E Kern; Taeko Yokochi; Y Eugene Chin; Gerard Karsenty; Tadatsugu Taniguchi; Hiroshi Takayanagi
Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation.
Genes & development 2003;17(16):1979-91.
2003: Leonieke Terpstra; Josée Prud'homme; Alice Arabian; Shu Takeda; Gerard Karsenty; Shoukat Dedhar; René St-Arnaud
Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes.
The Journal of cell biology 2003;162(1):139-48.
2003: Karim Fizazi; Jun Yang; Sara Peleg; Charles R Sikes; Erica L Kreimann; Danai D Daliani; Matilde Olive; Kevin A Raymond; Todd J Janus; Christopher J Logothetis; Gerard Karsenty; Nora M Navone
Prostate cancer cells-osteoblast interaction shifts expression of growth/survival-related genes in prostate cancer and reduces expression of osteoprotegerin in osteoblasts.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2587-97.
2003: Regis Levasseur; Roberto Barrios; Florent Elefteriou; Donald A Glass; Michael W Lieberman; Gerard Karsenty
Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice.
Endocrinology 2003;144(7):2761-4.
2003: Gerard Karsenty
The complexities of skeletal biology.
Nature 2003;423(6937):316-8.
2003: Qisheng Tu; Min Pi; Gerard Karsenty; Leigh Simpson; Shiguang Liu; L Darryl Quarles
Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background.
The Journal of clinical investigation 2003;111(7):1029-37.
2003: Cai-Bin Cui; Lyndon F Cooper; xiangli yang; Gerard Karsenty; Ikramuddin Aukhil
Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ.
Molecular and cellular biology 2003;23(3):1004-13.
2003: Sherif El-Maadawy; Mari T Kaartinen; Thorsten Schinke; Monzur Murshed; Gerard Karsenty; Marc McKee
Cartilage formation and calcification in arteries of mice lacking matrix Gla protein.
Connective tissue research 2003;44 Suppl 1():272-8.
2003: Shu Takeda; Florent Elefteriou; Gerard Karsenty
Common endocrine control of body weight, reproduction, and bone mass.
Annual review of nutrition 2003;23():403-11.
2003: Chantal Stheneur; Marie-France Dumontier; Claudie Guedes; Marie-Claude Fulchignoni-Lataud; Khadija Tahiri; Gerard Karsenty; Marie-Thérèse Corvol
Basic fibroblast growth factor as a selective inducer of matrix Gla protein gene expression in proliferative chondrocytes.
The Biochemical journal 2003;369(Pt 1):63-70.
2002: Shu Takeda; Florent Elefteriou; Regis Levasseur; Xiuyun Liu; Liping Zhao; Keith L Parker; Dawna Armstrong; Patricia Ducy; Gerard Karsenty
Leptin regulates bone formation via the sympathetic nervous system.
Cell 2002;111(3):305-17.
2002: Benjamin A Byers; Grace K Pavlath; Thomas J Murphy; Gerard Karsenty; Andres J Garcia
Cell-type-dependent up-regulation of in vitro mineralization after overexpression of the osteoblast-specific transcription factor Runx2/Cbfal.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(11):1931-44.
2002: Mei Y Speer; Marc McKee; Robert E Guldberg; Lucy Liaw; Hsueh-Ying Yang; Elyse Tung; Gerard Karsenty; Cecilia M Giachelli
Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo.
The Journal of experimental medicine 2002;196(8):1047-55.
2002: xiangli yang; Gerard Karsenty
Transcription factors in bone: developmental and pathological aspects.
Trends in molecular medicine 2002;8(7):340-5.
2002: Romain Dacquin; Michael Starbuck; Thorsten Schinke; Gerard Karsenty
Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast.
Developmental dynamics : an official publication of the American Association of Anatomists 2002;224(2):245-51.
2002: Tatsuya Kobayashi; Ung-il Chung; Ernestina Schipani; Michael Starbuck; Gerard Karsenty; Takenobu Katagiri; Dale L Goad; Beate Lanske; Henry M Kronenberg
PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps.
Development (Cambridge, England) 2002;129(12):2977-86.
2002: Millan S Patel; Gerard Karsenty
Regulation of bone formation and vision by LRP5.
The New England journal of medicine 2002;346(20):1572-4.
2002: Masaki Kato; Millan S Patel; Regis Levasseur; Ivan Lobov; Benny Hung-Junn Chang; Donald A Glass; Christine Hartmann; Lan Li; Tae-Ho Hwang; CORY BRAYTON; Richard Lang; Gerard Karsenty; Lawrence Chan
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor.
The Journal of cell biology 2002;157(2):303-14.
2002: Gerard Karsenty
[Central control of bone formation].
Annales d'endocrinologie 2002;63(2 Pt 1):145-53.
2002: Gerard Karsenty; Erwin F Wagner
Reaching a genetic and molecular understanding of skeletal development.
Developmental cell 2002;2(4):389-406.
2002: Richard C D'Alonzo; Nagarajan Selvamurugan; Gerard Karsenty; Nicola C Partridge
Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation.
The Journal of biological chemistry 2002;277(1):816-22.
2002: Stuart Tyner; Sundaresan Venkatachalam; Jene Choi; Stephen Jones; Nader Ghebranious; Herbert Igelmann; Xiongbin Lu; Gabrielle Soron; Benjamin Cooper; CORY BRAYTON; Timothy Thompson; Gerard Karsenty; Allan Bradley; Sang Hee Park; Lawrence A Donehower
p53 mutant mice that display early ageing-associated phenotypes.
Nature 2002;415(6867):45-53.
2002: Shuo Chen; Ting Ting Gu; Taduru Sreenath; Ashok Kulkarni; Gerard Karsenty; Mary MacDougall
Spatial expression of Cbfa1/Runx2 isoforms in teeth and characterization of binding sites in the DSPP gene.
Connective tissue research 2002;43(2-3):338-44.
2001: F B Riquet; Lujian Tan; Bob K Choy; Makoto Osaki; Gerard Karsenty; T F Osborne; Philip E. auron; Mary B Goldring
YY1 is a positive regulator of transcription of the Col1a1 gene.
The Journal of biological chemistry 2001;276(42):38665-72.
2001: Jun Yang; Karim Fizazi; Sara Peleg; Charles R Sikes; A Kevin Raymond; N Jamal; Min Hu; Matilde Olive; Luis A. Martinez; Christopher G Wood; Christopher J Logothetis; Gerard Karsenty; Nora M Navone
Prostate cancer cells induce osteoblast differentiation through a Cbfa1-dependent pathway.
Cancer research 2001;61(14):5652-9.
2001: Gerard Karsenty
Minireview: transcriptional control of osteoblast differentiation.
Endocrinology 2001;142(7):2731-3.
2001: Gerard Karsenty
When developmental biology meets human pathology.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5385-6.
2001: B Kern; Jianhe Shen; Michael Starbuck; Gerard Karsenty
Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes.
The Journal of biological chemistry 2001;276(10):7101-7.
2001: S Takeda; J P Bonnamy; M J Owen; Patricia Ducy; Gerard Karsenty
Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice.
Genes & development 2001;15(4):467-81.
2001: Gerard Karsenty
Chondrogenesis just ain't what it used to be.
The Journal of clinical investigation 2001;107(4):405-7.
2001: Michael Amling; Pia Pogoda; Frank Timo Beil; Arndt F Schilling; T Holzmann; Matthias Priemel; Dagmar Blicharski; P Català-Lehnen; Johannes M Rueger; Patricia Ducy; Gerard Karsenty
Central control of bone mass: brainstorming of the skeleton.
Advances in experimental medicine and biology 2001;496():85-94.
2001: S Takeda; Gerard Karsenty
Central control of bone formation.
Journal of bone and mineral metabolism 2001;19(3):195-8.
2001: Gerard Karsenty
Genetic control of skeletal development.
Novartis Foundation symposium 2001;232():6-17; discussion 17-22.
2001: Gerard Karsenty
Leptin controls bone formation through a hypothalamic relay.
Recent progress in hormone research 2001;56():401-15.
2000: Gerard Karsenty
Role of Cbfa1 in osteoblast differentiation and function.
Seminars in cell & developmental biology 2000;11(5):343-6.
2000: Patricia Ducy; Thorsten Schinke; Gerard Karsenty
The osteoblast: a sophisticated fibroblast under central surveillance.
Science (New York, N.Y.) 2000;289(5484):1501-4.
2000: Thomas Günther; Z F Chen; J Kim; Matthias Priemel; Johannes M Rueger; Michael Amling; J M Moseley; T J Martin; D J Anderson; Gerard Karsenty
Genetic ablation of parathyroid glands reveals another source of parathyroid hormone.
Nature 2000;406(6792):199-203.
2000: Guozhi Xiao; Di Jiang; P Thomas; Mark D Benson; Kunliang Guan; Gerard Karsenty; Renny Franceschi
MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1.
The Journal of biological chemistry 2000;275(6):4453-9.
2000: Patricia Ducy; Michael Amling; Shu Takeda; Matthias Priemel; Arndt F Schilling; Frank Timo Beil; J Shen; C Vinson; Johannes M Rueger; Gerard Karsenty
Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass.
Cell 2000;100(2):197-207.
2000: Keith W McLarren; Rita Lo; D Grbavec; K Thirunavukkarasu; Gerard Karsenty; Stefano Stifani
The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfa1.
The Journal of biological chemistry 2000;275(1):530-8.
1999: Gerard Karsenty
The genetic transformation of bone biology.
Genes & development 1999;13(23):3037-51.
1999: Guang Zhou; Yuqing Chen; L Zhou; K Thirunavukkarasu; J Hecht; David Chitayat; B D Gelb; S Pirinen; S A Berry; C R Greenberg; Gerard Karsenty; Brendan Lee
CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasia.
Human molecular genetics 1999;8(12):2311-6.
1999: Thorsten Schinke; Gerard Karsenty
Characterization of Osf1, an osteoblast-specific transcription factor binding to a critical cis-acting element in the mouse Osteocalcin promoters.
The Journal of biological chemistry 1999;274(42):30182-9.
1999: H Vogel; D S Lim; Gerard Karsenty; Milton Finegold; Edward Hasty
Deletion of Ku86 causes early onset of senescence in mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(19):10770-5.
1999: Gerard Karsenty; Patricia Ducy; Michael Starbuck; Matthias Priemel; Jianhe Shen; V Geoffroy; Michael Amling
Cbfa1 as a regulator of osteoblast differentiation and function.
Bone 1999;25(1):107-8.
1999: Patricia Ducy; Michael Starbuck; Matthias Priemel; Jianhe Shen; Gerald J Pinero; V Geoffroy; Michael Amling; Gerard Karsenty
A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development.
Genes & development 1999;13(8):1025-36.
1999: Thorsten Schinke; Marc McKee; Gerard Karsenty
Extracellular matrix calcification: where is the action?
Nature genetics 1999;21(2):150-1.
1998: Guozhi Xiao; Dian Wang; Mark D Benson; Gerard Karsenty; Renny Franceschi
Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor.
The Journal of biological chemistry 1998;273(49):32988-94.
1998: Thorsten Schinke; Marc McKee; R Kiviranta; Gerard Karsenty
Molecular determinants of arterial calcification.
Annals of medicine 1998;30(6):538-41.
1998: J L Frendo; G Xiao; S Fuchs; Renny Franceschi; Gerard Karsenty; Patricia Ducy
Functional hierarchy between two OSE2 elements in the control of osteocalcin gene expression in vivo.
The Journal of biological chemistry 1998;273(46):30509-16.
1998: DA Corral; Michael Amling; Matthias Priemel; Evelyne M Loyer; S Fuchs; Patricia Ducy; R Baron; Gerard Karsenty
Dissociation between bone resorption and bone formation in osteopenic transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13835-40.
1998: Patricia Ducy; Gerard Karsenty
Genetic control of cell differentiation in the skeleton.
Current opinion in cell biology 1998;10(5):614-9.
1998: Di Chen; X Ji; Marie A Harris; Jian Q Feng; Gerard Karsenty; Arkady Celeste; Vicki Rosen; Gregory R Mundy; Stephen E Harris
Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages.
The Journal of cell biology 1998;142(1):295-305.
1998: K Thirunavukkarasu; M Mahajan; Keith W McLarren; Stefano Stifani; Gerard Karsenty
Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfbeta.
Molecular and cellular biology 1998;18(7):4197-208.
1998: Gerard Karsenty
Transcriptional regulation of osteoblast differentiation during development.
Frontiers in bioscience : a journal and virtual library 1998;3():d834-7.
1998: T Katagiri; S Boorla; J L Frendo; B L Hogan; Gerard Karsenty
Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice.
Developmental genetics 1998;22(4):340-8.
1998: Gerard Karsenty
Genetics of skeletogenesis.
Developmental genetics 1998;22(4):301-13.
1998: V Geoffroy; DA Corral; L Zhou; Brendan Lee; Gerard Karsenty
Genomic organization, expression of the human CBFA1 gene, and evidence for an alternative splicing event affecting protein function.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(1):54-7.
1997: Brendan Lee; K Thirunavukkarasu; L Zhou; L Pastore; A Baldini; J Hecht; V Geoffroy; Patricia Ducy; Gerard Karsenty
Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia.
Nature genetics 1997;16(3):307-10.
1997: Patricia Ducy; R Zhang; V Geoffroy; A L Ridall; Gerard Karsenty
Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation.
Cell 1997;89(5):747-54.
1997: G Luo; Patricia Ducy; Marc McKee; Gerald J Pinero; Evelyne M Loyer; Richard R Behringer; Gerard Karsenty
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein.
Nature 1997;386(6620):78-81.
1997: Ren Zhang; Patricia Ducy; Gerard Karsenty
1,25-dihydroxyvitamin D3 inhibits Osteocalcin expression in mouse through an indirect mechanism.
The Journal of biological chemistry 1997;272(1):110-6.
1996: P Galéra; R W Park; Patricia Ducy; M G Mattéi; Gerard Karsenty
c-Krox binds to several sites in the promoter of both mouse type I collagen genes. Structure/function study and developmental expression analysis.
The Journal of biological chemistry 1996;271(35):21331-9.
1996: Patricia Ducy; C Desbois; B Boyce; G Pinero; B Story; C Dunstan; E Smith; J Bonadio; Steven A Goldstein; C Gundberg; Allan Bradley; Gerard Karsenty
Increased bone formation in osteocalcin-deficient mice.
Nature 1996;382(6590):448-52.
1996: Gerard Karsenty; G Luo; C Hofmann; A Bradley
BMP 7 is required for nephrogenesis, eye development, and skeletal patterning.
Annals of the New York Academy of Sciences 1996;785():98-107.
1996: Patricia Ducy; V Geoffroy; Gerard Karsenty
Study of osteoblast-specific expression of one mouse osteocalcin gene: characterization of the factor binding to OSE2.
Connective tissue research 1996;35(1-4):7-14.
1995: V Geoffroy; Patricia Ducy; Gerard Karsenty
A PEBP2 alpha/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element.
The Journal of biological chemistry 1995;270(52):30973-9.
1995: G Luo; C Hofmann; A L Bronckers; M Sohocki; Allan Bradley; Gerard Karsenty
BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.
Genes & development 1995;9(22):2808-20.
1995: Patricia Ducy; Gerard Karsenty
Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene.
Molecular and cellular biology 1995;15(4):1858-69.
1995: C Desbois; Gerard Karsenty
Osteocalcin cluster: implications for functional studies.
Journal of cellular biochemistry 1995;57(3):379-83.
1995: G Luo; R D'Souza; D Hogue; Gerard Karsenty
The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995;10(2):325-34.
1994: P Galéra; M Musso; Patricia Ducy; Gerard Karsenty
c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9372-6.
1994: C Desbois; Michael F Seldin; Gerard Karsenty
Localization of the osteocalcin gene cluster on mouse chromosome 3.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(5):321-2.
1994: C Desbois; D A Hogue; Gerard Karsenty
The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression.
The Journal of biological chemistry 1994;269(2):1183-90.
1992: H Goldberg; T Helaakoski; Lee Ann Garrett-Sinha; Gerard Karsenty; A Pellegrino; Guillermina Lozano; SANKAR MAITY; Benoit de Crombrugghe
Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells.
The Journal of biological chemistry 1992;267(27):19622-30.
1991: Gerard Karsenty; Roberto Ravazzolo; Benoit de Crombrugghe
Purification and functional characterization of a DNA-binding protein that interacts with a negative element in the mouse alpha 1(I) collagen promoter.
The Journal of biological chemistry 1991;266(36):24842-8.
1991: Benoit de Crombrugghe; T Vuorio; Gerard Karsenty; SANKAR MAITY; E C Rutheshouser; H Goldberg
Transcriptional control mechanisms for the expression of type I collagen genes.
Annals of the rheumatic diseases 1991;50 Suppl 4():872-6.
1991: Samuel W Beenken; Gerard Karsenty; L Raycroft; Guillermina Lozano
An intron binding protein is required for transformation ability of p53.
Nucleic acids research 1991;19(17):4747-52.
1991: Roberto Ravazzolo; Gerard Karsenty; Benoit de Crombrugghe
A fibroblast-specific factor binds to an upstream negative control element in the promoter of the mouse alpha 1(I) collagen gene.
The Journal of biological chemistry 1991;266(12):7382-7.
1990: Gerard Karsenty; Benoit de Crombrugghe
Two different negative and one positive regulatory factors interact with a short promoter segment of the alpha 1 (I) collagen gene.
The Journal of biological chemistry 1990;265(17):9934-42.
1990: Benoit de Crombrugghe; T Vuorio; Gerard Karsenty
Control of type I collagen genes in scleroderma and normal fibroblasts.
Rheumatic diseases clinics of North America 1990;16(1):109-23.
1990: Benoit de Crombrugghe; Gerard Karsenty; SANKAR MAITY; T Vuorio; P Rossi; E C Ruteshouser; S H McKinney; Guillermina Lozano
Transcriptional mechanisms controlling types I and III collagen genes.
Annals of the New York Academy of Sciences 1990;580():88-96.
1988: Gerard Karsenty; P Golumbek; Benoit de Crombrugghe
Point mutations and small substitution mutations in three different upstream elements inhibit the activity of the mouse alpha 2(I) collagen promoter.
The Journal of biological chemistry 1988;263(27):13909-15.
1988: SANKAR MAITY; P T Golumbek; Gerard Karsenty; B de Crombrugghe
Selective activation of transcription by a novel CCAAT binding factor.
Science (New York, N.Y.) 1988;241(4865):582-5.