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Khosrow Kashfi

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TOP 3
Ravinder Kodela; Kamran V Nia; Praveen P N Rao; Carlos A Velázquez-Martínez; Mitali Chattopadhyay; Zong Yuan Gan; Satindra Goswami; Khosrow Kashfi
Positional isomers of aspirin are equally potent in inhibiting colon cancer cell growth: differences in mode of cyclooxygenase inhibition.
Khosrow Kashfi
Dysfunctional cell signaling dynamics in oncology: diagnostic, prognostic and treatment opportunities.
Khosrow Kashfi; Kenneth R Olson
Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras.

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All Publications

2013: Ravinder Kodela; Kamran V Nia; Praveen P N Rao; Carlos A Velázquez-Martínez; Mitali Chattopadhyay; Zong Yuan Gan; Satindra Goswami; Khosrow Kashfi
Positional isomers of aspirin are equally potent in inhibiting colon cancer cell growth: differences in mode of cyclooxygenase inhibition.
The Journal of pharmacology and experimental therapeutics 2013;345(1):85-94.
2013: Khosrow Kashfi
Dysfunctional cell signaling dynamics in oncology: diagnostic, prognostic and treatment opportunities.
Biochemical pharmacology 2013;85(5):595-6.
2013: Khosrow Kashfi; Kenneth R Olson
Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras.
Biochemical pharmacology 2013;85(5):689-703.
2013: Niharika Nath; Xiaoping Liu; Lloydine Jacobs; Khosrow Kashfi
Flurbiprofen benzyl nitrate (NBS-242) inhibits the growth of A-431 human epidermoid carcinoma cells and targets β-catenin.
Drug design, development and therapy 2013;7():389-96.
2012: Mitali Chattopadhyay; Ravinder Kodela; Kenneth R Olson; Khosrow Kashfi
NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model.
Biochemical and biophysical research communications 2012;419(3):523-8.
2012: Mitali Chattopadhyay; Yosef M Dastagirzada; Ravinder Kodela; Niharika Nath; Carlos A Velázquez-Martínez; Daniel Boring; Khosrow Kashfi
Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: a general property and evidence of a tissue type-independent effect.
Biochemical pharmacology 2012;83(6):715-22.
2012: Mitali Chattopadhyay; Arpine Barsegian; Daniel Boring; Ravinder Kodela; Niharika Nath; Khosrow Kashfi
Hydrogen sulfide-releasing aspirin suppresses NF-κB signaling in estrogen receptor negative breast cancer cells in vitro and in vivo.
Biochemical pharmacology 2012;83(6):723-32.
2012: Mitali Chattopadhyay; Daniel Boring; Ravinder Kodela; Niharika Nath; Cherease R Street; Carlos A Velázquez-Martínez; Khosrow Kashfi
Hydrogen sulfide-releasing aspirin modulates xenobiotic metabolizing enzymes in vitro and in vivo.
Biochemical pharmacology 2012;83(6):733-40.
2012: Sarthak Jain; Paul Jurasz; Khosrow Kashfi; Susan Tran; Mohamed A M El Gendy; Carlos A Velázquez-Martínez
Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.
Journal of medicinal chemistry 2012;55(2):688-96.
2011: Ravinder Kodela; Niharika Nath; Liliya Pospishill; Daniel Boring; Mitali Chattopadhyay; Lucyna Z Cieciura; James A Crowell; Khosrow Kashfi
Synthesis and biological activity of acetyl-protected hydroxybenzyl diethyl phosphates (EHBP) as potential chemotherapeutic agents.
Bioorganic & medicinal chemistry letters 2011;21(23):7146-50.
2011: Khosrow Kashfi; Randall L Mynatt; Edwards A Park; George A Cook
Membrane microenvironment regulation of carnitine palmitoyltranferases I and II.
Biochemical Society transactions 2011;39(3):833-7.
2010: Mitali Chattopadhyay; Satindra Goswami; Deborah B Rodes; Ravinder Kodela; Carlos A Velazquez; Daniel Boring; James A Crowell; Khosrow Kashfi
NO-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo through S-nitrosylation.
Cancer letters 2010;298(2):204-11.
2010: Niharika Nath; Mitali Chattopadhyay; Liliya Pospishil; Lucyna Z Cieciura; Satindra Goswami; Ravinder Kodela; Joseph E Saavedra; Larry K Keefer; Khosrow Kashfi
JS-K, a nitric oxide-releasing prodrug, modulates ß-catenin/TCF signaling in leukemic Jurkat cells: evidence of an S-nitrosylated mechanism.
Biochemical pharmacology 2010;80(11):1641-9.
2010: Mitali Chattopadhyay; Carlos A Velazquez; April Pruski; Kamran V Nia; Khaled R Abdellatif; Larry K Keefer; Khosrow Kashfi
Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as safe anti-inflammatory, analgesic, antipyretic, antioxidant prodrugs.
The Journal of pharmacology and experimental therapeutics 2010;335(2):443-50.
2010: Niharika Nath; Mitali Chattopadhyay; Ravinder Kodela; Song Tian; Peter Vlismas; Daniel Boring; James A Crowell; Khosrow Kashfi
Modulation of stress genes expression profile by nitric oxide-releasing aspirin in Jurkat T leukemia cells.
Biochemical pharmacology 2010;79(12):1759-71.
2009: Niharika Nath; Rashida Vassell; Mitali Chattopadhyay; Marsel Kogan; Khosrow Kashfi
Nitro-aspirin inhibits MCF-7 breast cancer cell growth: effects on COX-2 expression and Wnt/beta-catenin/TCF-4 signaling.
Biochemical pharmacology 2009;78(10):1298-304.
2009: Khosrow Kashfi
Anti-inflammatory agents as cancer therapeutics.
Advances in pharmacology (San Diego, Calif.) 2009;57():31-89.
2007: Khosrow Kashfi; Basil Rigas
The mechanism of action of nitric oxide-donating aspirin.
Biochemical and biophysical research communications 2007;358(4):1096-101.
2006: Nengtai Ouyang; Jennie L Williams; George J Tsioulias; Jianjun Gao; Michael J Iatropoulos; Levy Kopelovich; Khosrow Kashfi; Basil Rigas
Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model.
Cancer research 2006;66(8):4503-11.
2006: Jianjun Gao; Khosrow Kashfi; Xiaoping Liu; Basil Rigas
NO-donating aspirin induces phase II enzymes in vitro and in vivo.
Carcinogenesis 2006;27(4):803-10.
2005: Adam Spiegel; Thomas R Hundley; Jie Chen; Jianjun Gao; Nengtai Ouyang; Xiaoping Liu; Mae F Go; George J Tsioulias; Khosrow Kashfi; Basil Rigas
NO-donating aspirin inhibits both the expression and catalytic activity of inducible nitric oxide synthase in HT-29 human colon cancer cells.
Biochemical pharmacology 2005;70(7):993-1000.
2005: Khosrow Kashfi; Basil Rigas
Non-COX-2 targets and cancer: expanding the molecular target repertoire of chemoprevention.
Biochemical pharmacology 2005;70(7):969-86.
2005: Prashant S Savle; Nicole E Neptune; Yanyan Yang; Jacques H Rouden; Brett L Kite; Eko W Sugandhi; Richard V Macri; Khosrow Kashfi; Richard D Gandour
Comparison of (+)- and (-)-hemipalmitoylcarnitinium as inhibitors of hepatic mitochondrial carnitine palmitoyltransferases in diabetic rats.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2005;1(5):445-53.
2005: Khosrow Kashfi; Basil Rigas
Is COX-2 a 'collateral' target in cancer prevention?
Biochemical Society transactions 2005;33(Pt 4):724-7.
2005: Khosrow Kashfi; Basil Rigas
Molecular targets of nitric-oxide-donating aspirin in cancer.
Biochemical Society transactions 2005;33(Pt 4):701-4.
2005: Basil Rigas; Khosrow Kashfi
Cancer prevention: a new era beyond cyclooxygenase-2.
The Journal of pharmacology and experimental therapeutics 2005;314(1):1-8.
2005: Khosrow Kashfi; Simona Borgo; Jennie L Williams; Jie Chen; Jianjun Gao; Athanasios Glekas; Francesca Benedini; Piero Del Soldato; Basil Rigas
Positional isomerism markedly affects the growth inhibition of colon cancer cells by nitric oxide-donating aspirin in vitro and in vivo.
The Journal of pharmacology and experimental therapeutics 2005;312(3):978-88.
2005: Jianjun Gao; Khosrow Kashfi; Basil Rigas
In vitro metabolism of nitric oxide-donating aspirin: the effect of positional isomerism.
The Journal of pharmacology and experimental therapeutics 2005;312(3):989-97.
2005: Niharika Nath; Georges Labaze; Basil Rigas; Khosrow Kashfi
NO-donating aspirin inhibits the growth of leukemic Jurkat cells and modulates beta-catenin expression.
Biochemical and biophysical research communications 2005;326(1):93-9.
2004: Basil Rigas; Khosrow Kashfi
Nitric-oxide-donating NSAIDs as agents for cancer prevention.
Trends in molecular medicine 2004;10(7):324-30.
2004: Raymond K Yeh; Jie Chen; Jennie L Williams; Mehdi Baluch; Thomas R Hundley; Raphael E Rosenbaum; Srinivas Kalala; Frank Traganos; Francesca Benardini; Piero Del Soldato; Khosrow Kashfi; Basil Rigas
NO-donating nonsteroidal antiinflammatory drugs (NSAIDs) inhibit colon cancer cell growth more potently than traditional NSAIDs: a general pharmacological property?
Biochemical pharmacology 2004;67(12):2197-205.
2004: Jennie L Williams; Khosrow Kashfi; Nengtai Ouyang; Piero Del Soldato; Levy Kopelovich; Basil Rigas
NO-donating aspirin inhibits intestinal carcinogenesis in Min (APC(Min/+)) mice.
Biochemical and biophysical research communications 2004;313(3):784-8.
2003: Jennie L Williams; Niharika Nath; Jie Chen; Thomas R Hundley; Jianjun Gao; Levy Kopelovich; Khosrow Kashfi; Basil Rigas
Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB, and NO synthase 2 inhibition: implications for chemoprevention.
Cancer research 2003;63(22):7613-8.
2003: Niharika Nath; Khosrow Kashfi; Jie Chen; Basil Rigas
Nitric oxide-donating aspirin inhibits beta-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear beta-catenin-TCF association.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12584-9.
2002: Khosrow Kashfi; Yassir Ryan; Leon L Qiao; Jennie L Williams; Jie Chen; Piero Del Soldato; Frank Traganos; Basil Rigas; Yassir Ryann
Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: evidence of a tissue type-independent effect.
The Journal of pharmacology and experimental therapeutics 2002;303(3):1273-82.
2002: Chatargy S Kaza; Khosrow Kashfi; Basil Rigas
Colon cancer prevention with NO-releasing NSAIDs.
Prostaglandins & other lipid mediators 2002;67(2):107-20.
2001: G Merritt; E T Aliprandis; F Prada; Basil Rigas; Khosrow Kashfi
The retinoid fenretinide inhibits proliferation and downregulates cyclooxygenase-2 gene expression in human colon adenocarcinoma cell lines.
Cancer letters 2001;164(1):15-23.
1997: E T Aliprandis; G Merritt; F Prada; Basil Rigas; Khosrow Kashfi
Fenretinide inhibits phorbol ester-induced cyclooxygenase-2 expression in human colon adenocarcinoma cells.
Biochemical Society transactions 1997;25(3):457S.