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Angela Kashuba

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Kristine B Patterson; Heather A Prince; Kimberly K Scarsi; Ruili Wang; Julie Dumond; Michael G Hudgens; Amanda J Jenkins; Stephanie Malone; Angela D M Kashuba
Protein binding of lopinavir and ritonavir during 4 phases of pregnancy: implications for treatment guidelines.
Katarina Ilic; Angela D M Kashuba; Celeste Lindley; Erin G Schuetz; Paul W Stewart; Ranjit K Thirumaran; Roy L Hawke; J Heyward Hull; Mei-Ling Chen
The influence of sex, ethnicity, and CYP2B6 genotype on bupropion metabolism as an index of hepatic CYP2B6 activity in humans.
David A Wohl; Suzanne Blevins; Julie Dumond; Joseph J Eron; Michelle Floris-Moore; Michael G Hudgens; Kelley Massengale; Donna Pittard; David Ragan; Amy Richardson; Kendall Walsh; Ruili Wang; Angela D M Kashuba
Raltegravir pharmacokinetics in treatment-naive patients is not influenced by race: results from the raltegravir early therapy in African-Americans living with HIV (REAL) study.

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2013: Kristine B Patterson; Heather A Prince; Kimberly K Scarsi; Ruili Wang; Julie Dumond; Michael G Hudgens; Amanda J Jenkins; Stephanie Malone; Angela D M Kashuba
Protein binding of lopinavir and ritonavir during 4 phases of pregnancy: implications for treatment guidelines.
Journal of acquired immune deficiency syndromes (1999) 2013;63(1):51-8.
2013: Katarina Ilic; Angela D M Kashuba; Celeste Lindley; Erin G Schuetz; Paul W Stewart; Ranjit K Thirumaran; Roy L Hawke; J Heyward Hull; Mei-Ling Chen
The influence of sex, ethnicity, and CYP2B6 genotype on bupropion metabolism as an index of hepatic CYP2B6 activity in humans.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(3):575-81.
2013: David A Wohl; Suzanne Blevins; Julie Dumond; Joseph J Eron; Michelle Floris-Moore; Michael G Hudgens; Kelley Massengale; Donna Pittard; David Ragan; Amy Richardson; Kendall Walsh; Ruili Wang; Angela D M Kashuba
Raltegravir pharmacokinetics in treatment-naive patients is not influenced by race: results from the raltegravir early therapy in African-Americans living with HIV (REAL) study.
Antimicrobial agents and chemotherapy 2013;57(2):784-8.
2012: Julie Dumond; Alan Forrest; Samira M Garonzik; Racheal N Kendrick; Melanie R Nicol; Kristine B Patterson; Myron S Cohen; Angela D M Kashuba
Pharmacokinetic modelling of efavirenz, atazanavir, lamivudine and tenofovir in the female genital tract of HIV-infected pre-menopausal women.
Clinical pharmacokinetics 2012;51(12):809-22.
2012: Kevin C Brown; Myron S Cohen; Steven H Jennings; Stephanie A Malone; Kristine B Patterson; Nicholas J Shaheen; Melissa Spacek; Heather M Asher Prince; Angela D M Kashuba
Single- and multiple-dose pharmacokinetics of darunavir plus ritonavir and etravirine in semen and rectal tissue of HIV-negative men.
Journal of acquired immune deficiency syndromes (1999) 2012;61(2):138-44.
2012: Jessica L Adams; Benjamin N Greener; Angela D M Kashuba
Pharmacology of HIV integrase inhibitors.
Current opinion in HIV and AIDS 2012;7(5):390-400.
2012: Myron S Cohen; Kathryn E Muessig; Kimberly A Powers; M Kumi Smith; Angela D M Kashuba
Antiviral agents and HIV prevention: controversies, conflicts, and consensus.
AIDS (London, England) 2012;26(13):1585-98.
2012: Jessica L Adams; Angela D M Kashuba
Formulation, pharmacokinetics and pharmacodynamics of topical microbicides.
Best practice & research. Clinical obstetrics & gynaecology 2012;26(4):451-62.
2012: Angela D M Kashuba; Kristine B Patterson; Julie Dumond; Myron S Cohen
Pre-exposure prophylaxis for HIV prevention: how to predict success.
Lancet 2012;379(9835):2409-11.
2012: Michael Cohen-Wolkowiez; Laura P James; Angela D M Kashuba; Nancy Newman; Ashley Ross; Janice E Sullivan; Michele C Walsh; Nicole R White; Arlene Zadell; Daniel K Benjamin; Daniele Ouellet
Population pharmacokinetics of piperacillin using scavenged samples from preterm infants.
Therapeutic drug monitoring 2012;34(3):312-9.
2012: Michael Cohen-Wolkowiez; Laura P James; Angela D M Kashuba; Nancy Newman; Daniele Ouellet; Ashley Ross; P Brian Smith; Janice E Sullivan; Michele C Walsh; Nicole R White; Arlene Zadell; Daniel K Benjamin
Population pharmacokinetics of metronidazole evaluated using scavenged samples from preterm infants.
Antimicrobial agents and chemotherapy 2012;56(4):1828-37.
2011: Michael Cohen-Wolkowiez; Daniel K Benjamin; Arlene Bridges; Nicole R White; Angela D M Kashuba
Development of a liquid chromatography-tandem mass spectrometry assay of six antimicrobials in plasma for pharmacokinetic studies in premature infants.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(30):3497-506.
2011: Gretchen S Stuart; Joseph Chintedze; Myron S Cohen; Amanda Corbett; Mina Hosseinipour; Wiza Kumwenda; Gabriel Malunga; Nkhafwire Mkandawire; Agnes Moses; Grace Phiri; Frank Z Stanczyk; Angela D M Kashuba
Combined oral contraceptives and antiretroviral PK/PD in Malawian women: pharmacokinetics and pharmacodynamics of a combined oral contraceptive and a generic combined formulation antiretroviral in Malawi.
Journal of acquired immune deficiency syndromes (1999) 2011;58(2):e40-3.
2011: Salim S Abdool Karim; Angela D M Kashuba; Lise Werner; Quarraisha Abdool Karim
Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women.
Lancet 2011;378(9787):279-81.
2011: Awewura Kwara; Pamela Poethke; Karen T Tashima; Michael H Court; Julie B Dumond; Angela D M Kashuba; Jaclyn Kurpewski; David J Greenblatt
Modest but variable effect of rifampin on steady-state plasma pharmacokinetics of efavirenz in healthy African-American and Caucasian volunteers.
Antimicrobial agents and chemotherapy 2011;55(7):3527-33.
2011: Kevin C Brown; Kristine B Patterson; Stephanie A Malone; Nicholas J Shaheen; Heather M Asher Prince; Julie B Dumond; Melissa B Spacek; Paris E Heidt; Myron S Cohen; Angela D M Kashuba
Single and multiple dose pharmacokinetics of maraviroc in saliva, semen, and rectal tissue of healthy HIV-negative men.
The Journal of infectious diseases 2011;203(10):1484-90.
2011: Kristine Patterson; Steven Jennings; Ron Falcon; Joseph Mrus; Angela D M Kashuba
Darunavir, ritonavir, and etravirine pharmacokinetics in the cervicovaginal fluid and blood plasma of HIV-infected women.
Antimicrobial agents and chemotherapy 2011;55(3):1120-2.
2011: Jill L Schwartz; Alfred Poindexter; Wes Rountree; Vivian Brache; Mitchell D Creinin; Angela D M Kashuba; Brian P Kearney
A multi-compartment, single and multiple dose pharmacokinetic study of the vaginal candidate microbicide 1% tenofovir gel.
PloS one 2011;6(10):e25974.
2010: M R Nicol; Angela D M Kashuba
Pharmacologic opportunities for HIV prevention.
Clinical pharmacology and therapeutics 2010;88(5):598-609.
2010: Mark A Winters; Koen K A Van Rompay; Angela D M Kashuba; Nancy S Shulman; Mark Holodniy
Maternal-fetal pharmacokinetics and dynamics of a single intrapartum dose of maraviroc in rhesus macaques.
Antimicrobial agents and chemotherapy 2010;54(10):4059-63.
2010: Willard Cates; Angela D M Kashuba
The North Carolina contribution to the CAPRISA 004 study: the Global Health Initiative in action.
North Carolina medical journal 2010;71(5):490-1.
2010: Sherry L Farr; Julie A E Nelson; Thokozani J Ng'ombe; Athena P Kourtis; Charles Chasela; Jeffrey A Johnson; Angela D M Kashuba; Gerald L Tegha; Jeffrey Wiener; Joseph J Eron; Harriet N Banda; Mwanangwa Mpaso; Jonathan Lipscomb; Chrissie Matiki; Susan A Fiscus; Denise J Jamieson; Charles van der Horst
Addition of 7 days of zidovudine plus lamivudine to peripartum single-dose nevirapine effectively reduces nevirapine resistance postpartum in HIV-infected mothers in Malawi.
Journal of acquired immune deficiency syndromes (1999) 2010;54(5):515-23.
2010: Julie Dumond; M Vourvahis; Abdel Naser La Rezk; Kristine B Patterson; Hsiao-Chuan Tien; N White; S H Jennings; S O Choi; J Li; M J Wagner; N M La-Beck; M Drulak; J P Sabo; M A Castles; T R Macgregor; Angela D M Kashuba
A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir.
Clinical pharmacology and therapeutics 2010;87(6):735-42.
2010: Amanda E Jones; Kevin C Brown; Rebecca E Werner; Karl Gotzkowsky; Andrea Gaedigk; Mike Blake; David W Hein; Charles van der Horst; Angela D M Kashuba
Variability in drug metabolizing enzyme activity in HIV-infected patients.
European journal of clinical pharmacology 2010;66(5):475-85.
2010: Charles Flexner; Camlin Tierney; Robert Gross; Adriana S A Andrade; Christina Lalama; Susan H Eshleman; Judith Aberg; Ian Sanne; Teresa Parsons; Angela D M Kashuba; Susan L Rosenkranz; Anne Kmack; Elaine Ferguson; Marjorie Dehlinger; Donna Mildvan
Comparison of once-daily versus twice-daily combination antiretroviral therapy in treatment-naive patients: results of AIDS clinical trials group (ACTG) A5073, a 48-week randomized controlled trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010;50(7):1041-52.
2010: S O Choi; Abdel Naser La Rezk; J S Kim; Angela D M Kashuba
Development of an LC-MS method for measuring TNF in human vaginal tissue.
Journal of chromatographic science 2010;48(3):219-23.
2010: Amanda H Corbett; Mina Hosseinipour; Jean Nyirenda; Cecelia Kanyama; Abdel Naser La Rezk; Pax Mkupani; Dorothy Sichali; Hsiao Tien; Angela D M Kashuba; Charles Mwansambo; Ralf Weigel; Peter N Kazembe
Pharmacokinetics of generic and trade formulations of lamivudine, stavudine and nevirapine in HIV-infected Malawian children.
Antiviral therapy 2010;15(1):83-90.
2010: MaryPeace McRae; Abdel Naser La Rezk; Arlene Bridges; Amanda H Corbett; Hsiao-Chuan Tien; Kim L R Brouwer; Angela D M Kashuba
Plasma bile acid concentrations in patients with human immunodeficiency virus infection receiving protease inhibitor therapy: possible implications for hepatotoxicity.
Pharmacotherapy 2010;30(1):17-24.
2010: Jasmine A Talameh; Abdel Naser La Rezk; Angela D M Kashuba
Quantifying the HIV-1 integrase inhibitor raltegravir in female genital tract secretions using high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(1):92-6.
2009: Abdel Naser La Rezk; Nicole R White; Steven H Jennings; Angela D M Kashuba
A novel LC-ESI-MS method for the simultaneous determination of etravirine, darunavir and ritonavir in human blood plasma.
Talanta 2009;79(5):1372-8.
2009: Paul Leger; Rebecca Dillingham; Carole Anne Beauharnais; Angela D M Kashuba; Abdel Naser La Rezk; Daniel W Fitzgerald; Jean William Pape; David W Haas
CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti.
The Journal of infectious diseases 2009;200(6):955-64.
2009: Awewura Kwara; Margaret Lartey; Isaac Boamah; Abdel Naser La Rezk; Joseph Oliver-Commey; Ernest Kenu; Angela D M Kashuba; Michael H Court
Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected Ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation.
Journal of clinical pharmacology 2009;49(9):1079-90.
2009: Julie Dumond; Kristine B Patterson; Allison L Pecha; Rebecca E Werner; Emma Andrews; Bharat Damle; Randall Tressler; Jochen Worsley; Angela D M Kashuba
Maraviroc concentrates in the cervicovaginal fluid and vaginal tissue of HIV-negative women.
Journal of acquired immune deficiency syndromes (1999) 2009;51(5):546-53.
2009: Shailesh K Choudhary; Abdel Naser La Rezk; William L Ince; Manzoor Cheema; L Zhang; Lishan Su; Ronald Swanstrom; Angela D M Kashuba; David M Margolis
Suppression of human immunodeficiency virus type 1 (HIV-1) viremia with reverse transcriptase and integrase inhibitors, CD4+ T-cell recovery, and viral rebound upon interruption of therapy in a new model for HIV treatment in the humanized Rag2-/-{gamma}c-/- mouse.
Journal of virology 2009;83(16):8254-8.
2009: Rosa F Yeh; Abdel Naser La Rezk; Angela D M Kashuba; Julie Dumond; Hiba L Tappouni; Hsiao-Chuan Tien; Ya-Chi Chen; Manoli Vourvahis; Amanda L Horton; Susan A Fiscus; Kristine B Patterson
Genital tract, cord blood, and amniotic fluid exposures of seven antiretroviral drugs during and after pregnancy in human immunodeficiency virus type 1-infected women.
Antimicrobial agents and chemotherapy 2009;53(6):2367-74.
2009: Yvonne Owens Ferguson; Eugenia Eng; Margaret E Bentley; Margarete Sandelowski; Allan Steckler; Elizabeth Randall-David; Ellen G Piwoz; Cynthia Zulu; Charles Chasela; Alice Soko; Martin Tembo; Francis Martinson; Beth Carlton Tohill; Yusuf Ahmed; Peter Kazembe; Denise J Jamieson; Charles van der Horst; Linda S Adair; Yusuf Ahmed; Mounir Ait-Khaled; Sandra Albrecht; Shrikant I Bangdiwala; Ronald Bayer; Margaret Bentley; Brian Bramson; Emily Bobrow; Nicola Boyle; Sal Butera; Charles Chasela; Charity Chavula; Joseph Chimerang'ambe; Maggie Chigwenembe; Maria Chikasema; Norah Chikhungu; David Chilongozi; Grace Chiudzu; Lenesi Chome; Anne Cole; Amanda H Corbett; Amy Corneli; Ann Duerr; Henry Eliya; Sascha Ellington; Joseph J Eron; Sherry Farr; Yvonne Owens Ferguson; Susan A Fiscus; Shannon Galvin; Laura A Guay; Chad Heilig; Irving F Hoffman; Elizabeth Hooten; Mina Hosseinipour; Michael G Hudgens; Stacy Hurst; Lisa Hyde; Denise Jamieson; George Joaki; David Jones; Zebrone Kacheche; Esmie Kamanga; Gift Kamanga; Coxcilly Kampani; Portia Kamthunzi; Deborah Kamwendo; Cecilia Kanyama; Angela D M Kashuba; Damson Kathyola; Dumbani Kayira; Peter N Kazembe; Rodney Knight; Athena Kourtis; Robert Krysiak; Jacob Kumwenda; Edde Loeliger; Misheck Luhanga; Victor Madhlopa; Maganizo Majawa; Alice Maida; Cheryl Marcus; Francis E A Martinson; Navdeep Thoofer; Chrissie Matika; Douglas Mayers; Isabel Mayuni; Marita McDonough; Joyce Meme; Ceppie Merry; Khama Mita; Chimwemwe Mkomawanthu; Gertrude Mndala; Ibrahim Mndala; Agnes Moses; Albans Msika; Wezi Msungama; Beatrice Mtimuni; Jane Muita; Noel Mumba; Bonface Musis; Charles Mwansambo; Gerald Mwapasa; Jacqueline Nkhoma; Richard Pendame; Ellen Piwoz; Byron Raines; Zane Ramdas; John Rublein; Mairin Ryan; Ian Sanne; Christopher Sellers; Diane Shugars; Dorothy Sichali; Wendy Snowden; Alice Soko; Allison Spensley; Jean-Marc Steens; Gerald Tegha; Martin Tembo; Roshan Thomas; Hsiao-Chuan Tien; Beth Tohill; Charles van der Horst; Esther Waalberg; Jeffrey Wiener; Cathy Wilfert; Patricia Wiyo; Onnocent Zgambo; Chifundo Zimba
Evaluating nurses' implementation of an infant-feeding counseling protocol for HIV-infected mothers: The Ban Study in Lilongwe, Malawi.
AIDS education and prevention : official publication of the International Society for AIDS Education 2009;21(2):141-55.
2009: Ngoc Ngo; Zhixia Yan; Tyler N Graf; Daniel R Carrizosa; Angela D M Kashuba; Elizabeth Dees; Nicholas H. Oberlies; Mary F Paine
Identification of a cranberry juice product that inhibits enteric CYP3A-mediated first-pass metabolism in humans.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(3):514-22.
2009: Kevin C Brown; Sunita Paul; Angela D M Kashuba
Drug interactions with new and investigational antiretrovirals.
Clinical pharmacokinetics 2009;48(4):211-41.
2008: Abdel Naser La Rezk; Nicole White; Angela D M Kashuba
An accurate and precise high-performance liquid chromatography method for the rapid quantification of the novel HIV integrase inhibitor raltegravir in human blood plasma after solid phase extraction.
Analytica chimica acta 2008;628(2):204-13.
2008: Abdel Naser La Rezk; Nicole White; Arlene Bridges; Mohamed F Abdel-Megeed; Tarek M Mohamed; Said S Moselhy; Angela D M Kashuba
Studies on antiretroviral drug concentrations in breast milk: validation of a liquid chromatography-tandem mass spectrometric method for the determination of 7 anti-human immunodeficiency virus medications.
Therapeutic drug monitoring 2008;30(5):611-9.
2008: Sarah J Schrieber; Zhiming Wen; Manoli Vourvahis; Philip C Smith; Michael W Fried; Angela D M Kashuba; Roy L Hawke
The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(9):1909-16.
2008: Martin Cranage; Sally Sharpe; Carolina Herrera; Alethea Cope; Mike Dennis; Neil Berry; Claire Ham; Jonathan Luke Heeney; Abdel Naser La Rezk; Angela D M Kashuba; Peter A Anton; Ian McGowan; Robin J Shattock
Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel.
PLoS medicine 2008;5(8):e157; discussion e157.
2008: Patrick J Roberts; Kristan D Rollins; Angela D M Kashuba; Mary F Paine; Andrew C Nelsen; Eric E Williams; Cassandra Moran; Jatinder Lamba; Erin G Schuetz; Roy L Hawke
The influence of CYP3A5 genotype on dexamethasone induction of CYP3A activity in African Americans.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(8):1465-9.
2008: Julie Dumond; Y Sunila Reddy; Luigi Troiani; Jose F Rodriguez; Arlene Bridges; Susan A Fiscus; Geoffrey J Yuen; Myron S Cohen; Angela D M Kashuba
Differential extracellular and intracellular concentrations of zidovudine and lamivudine in semen and plasma of HIV-1-infected men.
Journal of acquired immune deficiency syndromes (1999) 2008;48(2):156-62.
2008: YING-JUN CAO; Charles Flexner; Shelia Dunaway; Jeong-Gun Park; Karin L Klingman; Ilene Wiggins; Jeanne Conley; Christine Radebaugh; Angela D M Kashuba; Ronald T MacFarland; Stephen Becker; Craig W Hendrix
Effect of low-dose ritonavir on the pharmacokinetics of the CXCR4 antagonist AMD070 in healthy volunteers.
Antimicrobial agents and chemotherapy 2008;52(5):1630-4.
2008: Ann C Collier; Camlin Tierney; Gerald F Downey; Susan H Eshleman; Angela D M Kashuba; Karin Klingman; Emanuel N Vergis; Gary E Pakes; James F Rooney; Alex Rinehart; John W Mellors
Randomized study of dual versus single ritonavir-enhanced protease inhibitors for protease inhibitor-experienced patients with HIV.
HIV clinical trials 2008;9(2):91-102.
2008: Hiba L Tappouni; John C Rublein; Brian J Donovan; Stephanie B Hollowell; Hsiao-Chuan Tien; Sherene S Min; Dickens Theodore; Abdel Naser La Rezk; Philip C Smith; Melanie N Tallman; Ralph H Raasch; Angela D M Kashuba
Effect of omeprazole on the plasma concentrations of indinavir when administered alone and in combination with ritonavir.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2008;65(5):422-8.
2008: Awewura Kwara; Allison Delong; Abdel Naser La Rezk; Joseph Hogan; Heather Burtwell; Stacy Chapman; Carla C Moreira; Jaclynn Kurpewski; Jessica Ingersoll; Angela M Caliendo; Angela D M Kashuba; Susan Cu-Uvin
Antiretroviral drug concentrations and HIV RNA in the genital tract of HIV-infected women receiving long-term highly active antiretroviral therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;46(5):719-25.
2008: Manoli Vourvahis; Hiba L Tappouni; Kristine B Patterson; Ya-Chi Chen; Abdel Naser La Rezk; Susan A Fiscus; Brian P Kearney; James F Rooney; James Hui; Myron S Cohen; Angela D M Kashuba
The pharmacokinetics and viral activity of tenofovir in the male genital tract.
Journal of acquired immune deficiency syndromes (1999) 2008;47(3):329-33.
2008: Myron S Cohen; Angela D M Kashuba
Antiretroviral therapy for prevention of HIV infection: new clues from an animal model.
PLoS medicine 2008;5(2):e30.
2007: Byung Hwa Jung; Abdel Naser La Rezk; Arlene Bridges; Amanda H Corbett; Angela D M Kashuba
Simultaneous determination of 17 antiretroviral drugs in human plasma for quantitative analysis with liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC 2007;21(10):1095-104.
2007: Julie Dumond; Rosa F Yeh; Kristine B Patterson; Amanda H Corbett; Byung Hwa Jung; Abdel Naser La Rezk; Arlene Bridges; Paul W. Stewart; Myron S Cohen; Angela D M Kashuba
Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxis.
AIDS (London, England) 2007;21(14):1899-907.
2007: Abdel Naser La Rezk; Mohamed F Abdel-Megeed; Angela D M Kashuba
Development of a highly efficient extraction technique and specific multiplex assay for measuring antiretroviral drug concentrations in breast milk.
Therapeutic drug monitoring 2007;29(4):429-36.
2007: Manoli Vourvahis; Angela D M Kashuba
Mechanisms of pharmacokinetic and pharmacodynamic drug interactions associated with ritonavir-enhanced tipranavir.
Pharmacotherapy 2007;27(6):888-909.
2007: Myron S Cohen; Cynthia Gay; Angela D M Kashuba; Sally Blower; Lynn Paxton
Narrative review: antiretroviral therapy to prevent the sexual transmission of HIV-1.
Annals of internal medicine 2007;146(8):591-601.
2007: Sun Ok Choi; Abdel Naser La Rezk; Angela D M Kashuba
High-performance liquid chromatography assay for the determination of the HIV-protease inhibitor tipranavir in human plasma in combination with nine other antiretroviral medications.
Journal of pharmaceutical and biomedical analysis 2007;43(4):1562-7.
2007: Mina Hosseinipour; Amanda H Corbett; Cecelia Kanyama; Idah Mshali; Severiano Phakati; Abdel Naser La Rezk; Charles van der Horst; Angela D M Kashuba
Pharmacokinetic comparison of generic and trade formulations of lamivudine, stavudine and nevirapine in HIV-infected Malawian adults.
AIDS (London, England) 2007;21(1):59-64.
2007: G W Hogeland; S Swindells; J C McNabb; Angela D M Kashuba; G C Yee; Celeste Lindley
Lopinavir/ritonavir reduces bupropion plasma concentrations in healthy subjects.
Clinical pharmacology and therapeutics 2007;81(1):69-75.
2006: Abdel Naser La Rezk; Kevin C Brown; Angela D M Kashuba
A simple and sensitive bioanalytical assay for simultaneous determination of omeprazole and its three major metabolites in human blood plasma using RP-HPLC after a simple liquid-liquid extraction procedure.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;844(2):314-21.
2006: Mary Peace McRae; Carolina M Lowe; Xianbin Tian; David L Bourdet; Richard H Ho; Brenda F Leake; Richard B Kim; Kim L R Brouwer; Angela D M Kashuba
Ritonavir, saquinavir, and efavirenz, but not nevirapine, inhibit bile acid transport in human and rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 2006;318(3):1068-75.
2006: Abdel Naser La Rezk; Rustin D Crutchley; Rosa F Yeh; Angela D M Kashuba
Full validation of an analytical method for the HIV-protease inhibitor atazanavir in combination with 8 other antiretroviral agents and its applicability to therapeutic drug monitoring.
Therapeutic drug monitoring 2006;28(4):517-25.
2006: Amanda H Corbett; Kristine B Patterson; Hsiao-Chuan Tien; Leslie A Kalvass; Joseph J Eron; Linh T Ngo; Michael L Lim; Angela D M Kashuba
Dose separation does not overcome the pharmacokinetic interaction between fosamprenavir and lopinavir/ritonavir.
Antimicrobial agents and chemotherapy 2006;50(8):2756-61.
2006: Ya-Chi Chen; S Karl Gotzkowsky; Anne N Nafziger; Robert W Kulawy; Mario L Rocci; Joseph S Bertino; Angela D M Kashuba
Poor correlation between 6beta-hydroxycortisol:cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activity.
British journal of clinical pharmacology 2006;62(2):187-95.
2006: Myong-Jin Kim; Anne N Nafziger; Angela D M Kashuba; Julia Kirchheiner; Steffen Bauer; Andrea Gaedigk; Joseph S Bertino
Effects of fluvastatin and cigarette smoking on CYP2C9 activity measured using the probe S-warfarin.
European journal of clinical pharmacology 2006;62(6):431-6.
2006: Rosa F Yeh; Vincent E Gaver; Kristine B Patterson; Abdel Naser La Rezk; Faustina Baxter-Meheux; Michael J Blake; Joseph J Eron; Cheri E Klein; John C Rublein; Angela D M Kashuba
Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteers.
Journal of acquired immune deficiency syndromes (1999) 2006;42(1):52-60.
2005: Tatiana Shelepova; Anne N Nafziger; Jennifer Victory; Angela D M Kashuba; Elizabeth Rowland; Yanhua Zhang; Edward Sellers; Gregory Kearns; J Steven Leeder; Andrea Gaedigk; Joseph S Bertino
Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Journal of clinical pharmacology 2005;45(12):1413-21.
2005: Myron S Cohen; Angela D M Kashuba; Cynthia Gay
HIV antiretroviral postexposure prophylaxis: a cautionary note.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;41(10):1514-6.
2005: Abdel Naser La Rezk; Rustin D Crutchley; Angela D M Kashuba
Simultaneous quantification of emtricitabine and tenofovir in human plasma using high-performance liquid chromatography after solid phase extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;822(1-2):201-8.
2005: Angela D M Kashuba
Drug-drug interactions and the pharmacotherapy of HIV infection.
Topics in HIV medicine : a publication of the International AIDS Society, USA 2005;13(2):64-9.
2005: Angela D M Kashuba; Camlin Tierney; Gerald F Downey; Edward P Acosta; Emanuel N Vergis; Karin L Klingman; John W Mellors; Susan H Eshleman; Trevor R Scott; Ann C Collier
Combining fosamprenavir with lopinavir/ritonavir substantially reduces amprenavir and lopinavir exposure: ACTG protocol A5143 results.
AIDS (London, England) 2005;19(2):145-52.
2004: Sherene S Min; Amanda H Corbett; Abdel Naser La Rezk; Susan Cu-Uvin; Susan A Fiscus; Leslie Petch; Myron S Cohen; Angela D M Kashuba
Protease inhibitor and nonnucleoside reverse transcriptase inhibitor concentrations in the genital tract of HIV-1-infected women.
Journal of acquired immune deficiency syndromes (1999) 2004;37(5):1577-80.
2004: Michael L Lim; Sherene S Min; Joseph J Eron; Richard Bertz; Marjorie Robinson; Andrea Gaedigk; Angela D M Kashuba
Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction.
Journal of acquired immune deficiency syndromes (1999) 2004;36(5):1034-40.
2004: Amanda H Corbett; Joseph J Eron; Susan A Fiscus; Abdel Naser La Rezk; Angela D M Kashuba
The pharmacokinetics, safety, and initial virologic response of a triple-protease inhibitor salvage regimen containing amprenavir, saquinavir, and ritonavir.
Journal of acquired immune deficiency syndromes (1999) 2004;36(4):921-8.
2004: Mary Jayne Kennedy; Susan M Abdel-Rahman; Angela D M Kashuba; J Steven Leeder
Comparison of various urine collection intervals for caffeine and dextromethorphan phenotyping in children.
Journal of clinical pharmacology 2004;44(7):708-14.
2004: Abdel Naser La Rezk; Richard R Tidwell; Angela D M Kashuba
High-performance liquid chromatography assay for the quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;805(2):241-7.
2004: Joseph D Ma; Anne N Nafziger; Angela D M Kashuba; Myong-Jin Kim; Andrea Gaedigk; Elizabeth Rowland; Jooran S Kim; Joseph S Bertino
Limited sampling strategy of S-warfarin concentrations, but not warfarin S/R ratios, accurately predicts S-warfarin AUC during baseline and inhibition in CYP2C9 extensive metabolizers.
Journal of clinical pharmacology 2004;44(6):570-6.
2004: David A Wohl; Christopher D Pilcher; Scott Evans; Manuel Revuelta; Grace A McComsey; Yijun Yang; Robert Zackin; Beverly Alston; Stacey Welch; Michael Basar; Angela D M Kashuba; Pualani Kondo; Ana Martinez; Jeffrey Giardini; Joseph Quinn; Melvin Littles; Harry Wingfield; Susan L Koletar
Absence of sustained hyperlactatemia in HIV-infected patients with risk factors for mitochondrial toxicity.
Journal of acquired immune deficiency syndromes (1999) 2004;35(3):274-8.
2004: Mary Jayne Kennedy; Charity D Scripture; Angela D M Kashuba; Christy S Scott; Andrea Gaedigk; Gregory L Kearns
Activities of cytochrome P450 1A2, N-acetyltransferase 2, xanthine oxidase, and cytochrome P450 2D6 are unaltered in children with cystic fibrosis.
Clinical pharmacology and therapeutics 2004;75(3):163-71.
2004: Jeffrey A Sunman; Roy L Hawke; Edward LeCluyse; Angela D M Kashuba
Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(3):359-63.
2003: Siwaporn Chainuvati; Anne N Nafziger; J Steven Leeder; Andrea Gaedigk; Gregory L Kearns; Edward Sellers; Yanhua Zhang; Angela D M Kashuba; Elizabeth Rowland; Joseph S Bertino
Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Clinical pharmacology and therapeutics 2003;74(5):437-47.
2003: Abdel Naser La Rezk; Richard R Tidwell; Angela D M Kashuba
Simultaneous determination of six HIV nucleoside analogue reverse transcriptase inhibitors and nevirapine by liquid chromatography with ultraviolet absorbance detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;791(1-2):137-47.
2003: Y Sunila Reddy; Angela D M Kashuba; John Gerber; Veronica Miller
Roundtable report: importance of antiretroviral drug concentrations in sanctuary sites and viral reservoirs.
AIDS research and human retroviruses 2003;19(3):167-76.
2003: Jennifer A Lowry; Gregory L Kearns; Susan M Abdel-Rahman; Anne N Nafziger; Irim S Khan; Angela D M Kashuba; Erin G Schuetz; Joseph S Bertino; John N van den Anker; J Steven Leeder
Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo.
Clinical pharmacology and therapeutics 2003;73(3):209-22.
2003: Mary Peace McRae; Kim L R Brouwer; Angela D M Kashuba
Cytokine regulation of P-glycoprotein.
Drug metabolism reviews 2003;35(1):19-33.
2002: Y Sunila Reddy; S Karl Gotzkowsky; Joseph J Eron; Julie Y Kim; William D Fiske; Susan A Fiscus; Leslie Petch; Myron S Cohen; Angela D M Kashuba
Pharmacokinetic and pharmacodynamic investigation of efavirenz in the semen and blood of human immunodeficiency virus type 1-infected men.
The Journal of infectious diseases 2002;186(9):1339-43.
2002: Janyce F Rogers; Anne N Nafziger; Angela D M Kashuba; Daniel S Streetman; Mario L Rocci; Edna F Choo; Grant R Wilkinson; Joseph S Bertino
Single plasma concentrations of 1'-hydroxymidazolam or the ratio of 1'-hydroxymidazolam:midazolam do not predict midazolam clearance in healthy subjects.
Journal of clinical pharmacology 2002;42(10):1079-82.
2002: Naumann I Chaudry; Joseph J Eron; Odin J Naderer; Arlene S Pereira; Mary Beth Wire; Susan A Fiscus; Angela D M Kashuba
Effects of formulation and dosing strategy on amprenavir concentrations in the seminal plasma of human immunodeficiency virus type 1-infected men.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2002;35(6):760-2.
2002: Abdel Naser La Rezk; Richard R Tidwell; Angela D M Kashuba
Simple and rapid quantification of the non-nucleoside reverse transcriptase inhibitors nevirapine, delavirdine, and efavirenz in human blood plasma using high-performance liquid chromatography with ultraviolet absorbance detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;774(1):79-88.
2002: Amanda H Corbett; Michael L Lim; Angela D M Kashuba
Kaletra (lopinavir/ritonavir).
The Annals of pharmacotherapy 2002;36(7-8):1193-203.
2002: Mina Hosseinipour; Myron S Cohen; Pietro L Vernazza; Angela D M Kashuba
Can antiretroviral therapy be used to prevent sexual transmission of human immunodeficiency virus type 1?
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2002;34(10):1391-5.
2002: Jooran S Kim; Anne N Nafziger; Shirley M Tsunoda; Edna E Choo; Daniel S Streetman; Angela D M Kashuba; Robert W Kulawy; Debra J Beck; Mario L Rocci; Grant R Wilkinson; David J Greenblatt; Joseph S Bertino
Limited sampling strategy to predict AUC of the CYP3A phenotyping probe midazolam in adults: application to various assay techniques.
Journal of clinical pharmacology 2002;42(4):376-82.
2002: Amanda H Corbett; Angela D M Kashuba
Fosamprenavir. Vertex Pharmaceuticals/GlaxoSmithKline.
Current opinion in investigational drugs (London, England : 2000) 2002;3(3):384-90.
2002: Myron S Cohen; Mina Hosseinipour; Angela D M Kashuba; Salvatore Butera
Use of antiretroviral drugs to prevent sexual transmission of HIV.
Current clinical topics in infectious diseases 2002;22():214-51.
2001: H L Jordan; Arlene S Pereira; Myron S Cohen; Angela D M Kashuba
Domestic cat model for predicting human nucleoside analogue pharmacokinetics in blood and seminal plasma.
Antimicrobial agents and chemotherapy 2001;45(7):2173-6.
2001: Daniel S Streetman; Angela D M Kashuba; Joseph S Bertino; Robert W Kulawy; Mario L Rocci; Anne N Nafziger
Use of midazolam urinary metabolic ratios for cytochrome P450 3A (CYP3A) phenotyping.
Pharmacogenetics 2001;11(4):349-55.
2001: S Becker; A Fisher; Charles Flexner; John G Gerber; R Haubrich; Angela D M Kashuba; Andrew Luber; S C Piscitelli
Pharmacokinetic parameters of protease inhibitors and the Cmin/IC50 ratio: call for consensus.
Journal of acquired immune deficiency syndromes (1999) 2001;27(2):210-1.
2000: Vural Ozdemir; Werner Kalow; Bing-Kou Tang; A D Paterson; S E Walker; Laszlo Endrenyi; Angela D M Kashuba
Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method.
Pharmacogenetics 2000;10(5):373-88.
1999: Arlene S Pereira; Angela D M Kashuba; Susan A Fiscus; James Edwin Hall; Richard R Tidwell; L Troiani; John A Dunn; Joseph J Eron; Myron S Cohen
Nucleoside analogues achieve high concentrations in seminal plasma: relationship between drug concentration and virus burden.
The Journal of infectious diseases 1999;180(6):2039-43.
1999: Angela D M Kashuba; Anne N Nafziger; Gregory L Kearns; J Steven Leeder; RR Gotschall; Andrea Gaedigk; Joseph S Bertino
Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity.
Pharmacogenetics 1999;9(4):453-62.
1999: Angela D M Kashuba; JR Dyer; L M Kramer; Ralph H Raasch; Joseph J Eron; Myron S Cohen
Antiretroviral-drug concentrations in semen: implications for sexual transmission of human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 1999;43(8):1817-26.
1999: Anne N Nafziger; Joseph S Bertino; A I Goss-Bley; Angela D M Kashuba
Incidence of sexual dysfunction in healthy volunteers on fluvoxamine therapy.
The Journal of clinical psychiatry 1999;60(3):187-90.
1999: Angela D M Kashuba; Anne N Nafziger; George L Drusano; Joseph S Bertino
Optimizing aminoglycoside therapy for nosocomial pneumonia caused by gram-negative bacteria.
Antimicrobial agents and chemotherapy 1999;43(3):623-9.
1998: Angela D M Kashuba; Anne N Nafziger; Gregory L Kearns; J Steven Leeder; C S Shirey; RR Gotschall; Andrea Gaedigk; Joseph S Bertino
Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping.
Pharmacogenetics 1998;8(5):403-10.
1998: Angela D M Kashuba; Joseph S Bertino; Mario L Rocci; Robert W Kulawy; Debra J Beck; Anne N Nafziger
Quantification of 3-month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam.
Clinical pharmacology and therapeutics 1998;64(3):269-77.
1998: Angela D M Kashuba; Anne N Nafziger; Gregory L Kearns; J Steven Leeder; RR Gotschall; Mario L Rocci; Robert W Kulawy; Debra J Beck; Joseph S Bertino
Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.
Clinical pharmacology and therapeutics 1998;64(3):257-68.
1998: Angela D M Kashuba; Joseph S Bertino; Anne N Nafziger
Dosing of aminoglycosides to rapidly attain pharmacodynamic goals and hasten therapeutic response by using individualized pharmacokinetic monitoring of patients with pneumonia caused by gram-negative organisms.
Antimicrobial agents and chemotherapy 1998;42(7):1842-4.
1998: Angela D M Kashuba; Joseph S Bertino; Gregory L Kearns; J Steven Leeder; A W James; RR Gotschall; Anne N Nafziger
Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping.
Clinical pharmacology and therapeutics 1998;63(5):540-51.
1998: EF Trépanier; Anne N Nafziger; G L Kearns; Angela D M Kashuba; Guy W Amsden
Absence of effect of terbinafine on the activity of CYP1A2, NAT-2, and xanthine oxidase.
Journal of clinical pharmacology 1998;38(5):424-8.
1998: Angela D M Kashuba; Anne N Nafziger
Physiological changes during the menstrual cycle and their effects on the pharmacokinetics and pharmacodynamics of drugs.
Clinical pharmacokinetics 1998;34(3):203-18.
1998: Angela D M Kashuba; Guy W Amsden
Bronchopulmonary pharmacokinetics of clarithromycin and azithromycin.
Antimicrobial agents and chemotherapy 1998;42(2):481-2.
1996: Angela D M Kashuba; CH Ballow; Alan Forrest
Development and evaluation of a Bayesian pharmacokinetic estimator and optimal, sparse sampling strategies for ceftazidime.
Antimicrobial agents and chemotherapy 1996;40(8):1860-5.
1996: Angela D M Kashuba; CH Ballow
Legionella urinary antigen testing: potential impact on diagnosis and antibiotic therapy.
Diagnostic microbiology and infectious disease 1996;24(3):129-39.