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Jana Kasparkova
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Research Profile (preview)
Chemicals & Drugs
Physiology
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Anatomy
Phenomena
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Network (preview)
40
Brabec, Viktor
12
Farrell, Nicholas
8
Marini, Victoria
8
Novakova, Olga
7
Gibson, Dan
7
Najajreh, Yousef
5
Natile, Giovanni
4
Sadler, Peter
4
Malina, Jaroslav
4
Vrana, Oldrich
3
Vojtiskova, Marie
3
Perez, Jose Manuel
3
Khazanov, Elena
3
Kostrhunova, Hana
3
Barenholz, Yechezkel
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Geonetwork of Jana Kasparkova (preview)
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All Publications
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2010: Zerzankova Lenka; Suchankova Tereza; Vrana Oldrich; Farrell Nicholas P; Brabec Viktor; Kasparkova Jana
Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles.
Biochemical pharmacology 2010;79(2):112-21.
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2009: Ruhayel Rasha A; Moniodis Joseph J; Yang Xiaohong; Kasparkova Jana; Brabec Viktor; Berners-Price Susan J; Farrell Nicholas P
Factors affecting DNA-DNA interstrand cross-links in the antiparallel 3'-3' sense: a comparison with the 5'-5' directional isomer.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(37):9365-74.
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2009: Krause-Heuer Anwen M; Grünert Renate; Kühne Sybill; Buczkowska Magdalena; Wheate Nial J; Le Pevelen Delphine D; Boag Leanne R; Fisher Dianne M; Kasparkova Jana; Malina Jaroslav; Bednarski Patrick J; Brabec Viktor; Aldrich-Wright Janice R
Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells.
Journal of medicinal chemistry 2009;52(17):5474-84.
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2009: Heringova Pavla; Kasparkova Jana; Brabec Viktor
DNA adducts of antitumor cisplatin preclude telomeric sequences from forming G quadruplexes.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2009;14(6):959-68.
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2008: Bugarcic Tijana; Habtemariam Abraha; Stepankova Jana; Heringova Pavla; Kasparkova Jana; Deeth Robert J; Johnstone Russell D L; Prescimone Alessandro; Parkin Andrew; Parsons Simon; Brabec Viktor; Sadler Peter J
The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes.
Inorganic chemistry 2008;47(24):11470-86.
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2008: Kasparkova Jana; Marini Victoria; Bursova Vendula; Brabec Viktor
Biophysical studies on the stability of DNA intrastrand cross-links of transplatin.
Biophysical journal 2008;95(9):4361-71.
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2008: Castellano-Castillo Maria; Kostrhunova Hana; Marini Victoria; Kasparkova Jana; Sadler Peter J; Malinge Jean-Marc; Brabec Viktor
Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2008;13(6):993-9.
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2008: Hegmans Alexander; Kasparkova Jana; Vrana Oldrich; Kelland Lloyd R; Brabec Viktor; Farrell Nicholas P
Amide-based prodrugs of spermidine-bridged dinuclear platinum. Synthesis, DNA binding, and biological activity.
Journal of medicinal chemistry 2008;51(7):2254-60.
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2008: de Mier-Vinué Jordi; Gay Marina; Montaña Angel M; Sáez Rosa-Isabel; Moreno Virtudes; Kasparkova Jana; Vrana Oldrich; Heringova Pavla; Brabec Viktor; Boccarelli Angela; Coluccia Mauro; Natile Giovanni
Synthesis, biophysical studies, and antiproliferative activity of platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands.
Journal of medicinal chemistry 2008;51(3):424-31.
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2008: Kasparkova Jana; Vojtiskova Marie; Natile Giovanni; Brabec Viktor
Unique properties of DNA interstrand cross-links of antitumor oxaliplatin and the effect of chirality of the carrier ligand.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(4):1330-41.
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2007: Halamikova Anna; Vrana Oldrich; Kasparkova Jana; Brabec Viktor
Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair.
Chembiochem : a European journal of chemical biology 2007;8(16):2008-15.
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2007: Gallmeier Eike; Hucl Tomas; Brody Jonathan R; Dezentje David A; Tahir Khola; Kasparkova Jana; Brabec Viktor; Bachman Kurtis E; Kern Scott E
High-throughput screening identifies novel agents eliciting hypersensitivity in Fanconi pathway-deficient cancer cells.
Cancer research 2007;67(5):2169-77.
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2006: Heringova Pavla; Woods Julie; Mackay Fiona S; Kasparkova Jana; Sadler Peter J; Brabec Viktor
Transplatin is cytotoxic when photoactivated: enhanced formation of DNA cross-links.
Journal of medicinal chemistry 2006;49(26):7792-8.
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2006: Najajreh Yousef; Ardeli-Tzaraf Yael; Kasparkova Jana; Heringova Pavla; Prilutski Dmitri; Balter Liliana; Jawbry Seba; Khazanov Elena; Perez Jose Manuel; Barenholz Yechezkel; Brabec Viktor; Gibson Dan
Interactions of platinum complexes containing cationic, bicyclic, nonplanar piperidinopiperidine ligands with biological nucleophiles.
Journal of medicinal chemistry 2006;49(15):4674-83.
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2006: Najajreh Yousef; Khazanov Elena; Jawbry Seba; Ardeli-Tzaraf Yael; Perez Jose Manuel; Kasparkova Jana; Brabec Viktor; Barenholz Yechezkel; Gibson Dan
Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies.
Journal of medicinal chemistry 2006;49(15):4665-73.
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2005: Najajreh Yousef; Kasparkova Jana; Marini Victoria; Gibson Dan; Brabec Viktor
Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2005;10(7):722-31.
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2005: Brabec Viktor; Kasparkova Jana
Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2005;8(3):131-46.
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2005: Najajreh Yousef; Prilutski Dmitri; Ardeli-Tzaraf Yael; Perez Jose Manuel; Khazanov Elena; Barenholz Yechezkel; Kasparkova Jana; Brabec Viktor; Gibson Dan
Structure and unique interactions with DNA of a cationic trans-platinum complex with the nonplanar bicyclic piperidinopiperidine ligand.
Angewandte Chemie (International ed. in English) 2005;44(19):2885-7.
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2005: Bursova Vendula; Kasparkova Jana; Hofr Ctirad; Brabec Viktor
Effects of monofunctional adducts of platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes.
Biophysical journal 2005;88(2):1207-14.
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2005: Novakova Olga; Kasparkova Jana; Bursova Vendula; Hofr Ctirad; Vojtiskova Marie; Chen Haimei; Sadler Peter J; Brabec Viktor
Conformation of DNA modified by monofunctional Ru(II) arene complexes: recognition by DNA binding proteins and repair. Relationship to cytotoxicity.
Chemistry & biology 2005;12(1):121-9.
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2005: Marini Victoria; Christofis Petros; Novakova Olga; Kasparkova Jana; Farrell Nicholas; Brabec Viktor
Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)].
Nucleic acids research 2005;33(18):5819-28.
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2004: Kasparkova Jana; Vrana Oldrich; Farrell Nicholas; Brabec Viktor
Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding.
Journal of inorganic biochemistry 2004;98(10):1560-9.
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2004: Kloster Miriam; Kostrhunova Hana; Zaludova Renata; Malina Jaroslav; Kasparkova Jana; Brabec Viktor; Farrell Nicholas
Trifunctional dinuclear platinum complexes as DNA-protein cross-linking agents.
Biochemistry 2004;43(24):7776-86.
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2004: Prokop Radim; Kasparkova Jana; Novakova Olga; Marini Victoria; Pizarro Ana María; Navarro-Ranninger Carmen; Brabec Viktor
DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand.
Biochemical pharmacology 2004;67(6):1097-109.
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2004: Kasparkova Jana; Fojta Miroslav; Farrell Nicholas; Brabec Viktor
Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin.
Nucleic acids research 2004;32(18):5546-52.
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2003: Kasparkova Jana; Novakova Olga; Najajreh Yousef; Gibson Dan; Perez Jose-Manuel; Brabec Viktor
Effects of a piperidine ligand on DNA modification by antitumor cisplatin analogues.
Chemical research in toxicology 2003;16(11):1424-32.
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2003: Novakova Olga; Kasparkova Jana; Malina Jaroslav; Natile Giovanni; Brabec Viktor
DNA-protein cross-linking by trans-[PtCl(2)(E-iminoether)(2)]. A concept for activation of the trans geometry in platinum antitumor complexes.
Nucleic acids research 2003;31(22):6450-60.
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2003: Kasparkova Jana; Novakova Olga; Marini Victoria; Najajreh Yousef; Gibson Dan; Perez Jose-Manuel; Brabec Viktor
Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand. Mechanistic studies on antitumor action.
The Journal of biological chemistry 2003;278(48):47516-25.
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2003: Kasparkova Jana; Marini Victoria; Najajreh Yousef; Gibson Dan; Brabec Viktor
DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines.
Biochemistry 2003;42(20):6321-32.
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2003: Fojta Miroslav; Pivonkova Hana; Brazdova Marie; Kovarova Lucie; Palecek Emil; Pospisilova Sarka; Vojtesek Borivoj; Kasparkova Jana; Brabec Viktor
Recognition of DNA modified by antitumor cisplatin by "latent" and "active" protein p53.
Biochemical pharmacology 2003;65(8):1305-16.
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2003: Kasparkova Jana; Delalande Olivier; Stros Michal; Elizondo-Riojas Miguel-Angel; Vojtiskova Marie; Kozelka Jiri; Brabec Viktor
Recognition of DNA interstrand cross-link of antitumor cisplatin by HMGB1 protein.
Biochemistry 2003;42(5):1234-44.
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2003: Kasparkova Jana; Novakova Olga; Farrell Nicholas; Brabec Viktor
DNA binding by antitumor trans-[PtCl2(NH3)(thiazole)]. Protein recognition and nucleotide excision repair of monofunctional adducts.
Biochemistry 2003;42(3):792-800.
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2002: Kasparkova Jana; Zehnulova Jana; Farrell Nicholas; Brabec Viktor
DNA interstrand cross-links of the novel antitumor trinuclear platinum complex BBR3464. Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair.
The Journal of biological chemistry 2002;277(50):48076-86.
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2002: Benedetti Michele; Malina Jaroslav; Kasparkova Jana; Brabec Viktor; Natile Giovanni
Chiral discrimination in platinum anticancer drugs.
Environmental health perspectives 2002;110 Suppl 5():779-82.
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2002: Marini Victoria; Kasparkova Jana; Novakova Olga; Monsú Scolaro Luigi; Romeo Raffaello; Brabec Viktor
Biophysical analysis of natural, double-helical DNA modified by a dinuclear platinum(II) organometallic compound in a cell-free medium.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(7-8):725-34.
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2002: Brabec Viktor; Kasparkova Jana
Molecular aspects of resistance to antitumor platinum drugs.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2002;5(3-4):147-61.
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2002: Stehlikova Kristyna; Kostrhunova Hana; Kasparkova Jana; Brabec Viktor
DNA bending and unwinding due to the major 1,2-GG intrastrand cross-link formed by antitumor cis-diamminedichloroplatinum(II) are flanking-base independent.
Nucleic acids research 2002;30(13):2894-8.
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2002: Malina Jaroslav; Kasparkova Jana; Natile Giovanni; Brabec Viktor
Recognition of major DNA adducts of enantiomeric cisplatin analogs by HMG box proteins and nucleotide excision repair of these adducts.
Chemistry & biology 2002;9(5):629-38.
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2001: Zehnulova J; Kasparkova J; Farrell N; Brabec V
Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair of DNA intrastrand cross-links of novel antitumor trinuclear platinum complex BBR3464.
The Journal of biological chemistry 2001;276(25):22191-9.
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2001: Kasparkova J; Pospisilova S; Brabec V
Different recognition of DNA modified by aatitumor cisplatin and its clinically ineffective trans isomer by tumor suppressor protein p53.
The Journal of biological chemistry 2001;276(19):16064-9.
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2000: Brabec V; Neplechova K; Kasparkova J; Farrell N
Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(3):364-8.
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2000: Kasparkova J; Farrell N; Brabec V
Sequence specificity, conformation, and recognition by HMG1 protein of major DNA interstrand cross-links of antitumor dinuclear platinum complexes.
The Journal of biological chemistry 2000;275(21):15789-98.
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