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Jin Hyen Baek

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Paul W Buehler; Ian Connor; Jin Hyen Baek; Joe Bonaventura; Douglas Kominsky; Christina Lisk; Susan M Majka; Eva Nozik-Grayck; Kurt R Stenmark; Tim Sullivan; David C Irwin
Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.
Jin Hyen Baek; David R Harris; Andre F Palmer; Dominik J Schaer; Yipin Zhou; Paul W Buehler
Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig model.
Jin Hyen Baek; Felice D'Agnillo; Yiping Jia; Claudia P Pereira; Dominik J Schaer; Florence Vallelian; Matthew C Williams; Paul W Buehler
Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.

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2012: Paul W Buehler; Ian Connor; Jin Hyen Baek; Joe Bonaventura; Douglas Kominsky; Christina Lisk; Susan M Majka; Eva Nozik-Grayck; Kurt R Stenmark; Tim Sullivan; David C Irwin
Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.
American journal of physiology. Lung cellular and molecular physiology 2012;303(4):L312-26.
2012: Jin Hyen Baek; David R Harris; Andre F Palmer; Dominik J Schaer; Yipin Zhou; Paul W Buehler
Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig model.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(2):567-81.
2012: Jin Hyen Baek; Felice D'Agnillo; Yiping Jia; Claudia P Pereira; Dominik J Schaer; Florence Vallelian; Matthew C Williams; Paul W Buehler
Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.
The Journal of clinical investigation 2012;122(4):1444-58.
2012: Maimon E Hubbi; Jin Hyen Baek; Daniele M Gilkes; Gregg L Semenza
Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1.
The Journal of biological chemistry 2012;287(9):6139-49.
2011: Dominador J Manalo; Bindu Abraham; Jin Hyen Baek; Paul W Buehler; Evi Struble; Abdu I Alayash
Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1α) and induces hepcidin (Hamp) in rat kidney.
Biochemical and biophysical research communications 2011;416(3-4):421-6.
2011: Bindu Abraham; Jin Hyen Baek; Wayne Hicks; Yiping Jia; Jeffery L Miller; Abdu I Alayash
Isolated Hb Providence β82Asn and β82Asp fractions are more stable than native HbA(0) under oxidative stress conditions.
Biochemistry 2011;50(45):9752-66.
2011: Maimon E Hubbi; Weibo Luo; Jin Hyen Baek; Gregg L Semenza
MCM proteins are negative regulators of hypoxia-inducible factor 1.
Molecular cell 2011;42(5):700-12.
2011: Jin Hyen Baek; Chad E N Reiter; Dominador J Manalo; Paul W Buehler; Robert C Hider; Abdu I Alayash
Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94.
Biochimica et biophysica acta 2011;1809(4-6):262-8.
2008: Dominador J Manalo; Paul W Buehler; Jin Hyen Baek; Omer Butt; Felice D'Agnillo; Abdu I Alayash
Acellular haemoglobin attenuates hypoxia-inducible factor-1alpha (HIF-1alpha) and its target genes in haemodiluted rats.
The Biochemical journal 2008;414(3):461-9.
2008: Janghee Woo; Juna Lee; Young Kwang Chae; Myoung Sook Kim; Jin Hyen Baek; Jong Chul Park; Min Joo Park; Ian M Smith; Barry Trink; Edward Ratovitski; Taekyul Lee; Bumsoo Park; Se Jin Jang; Jean-Charles Soria; Joseph A Califano; David Sidransky; Chulso Moon
Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation.
Cancer letters 2008;264(1):54-62.
2008: Myoung Sook Kim; Xiaofei Chang; Keishi Yamashita; JATIN NAGPAL; Jin Hyen Baek; Guojun Wu ; Barry Trink; Edward Ratovitski; M Mori; David Sidransky
Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma.
Oncogene 2008;27(25):3624-34.
2008: Hannah Lui Park; Myoung Sook Kim; Keishi Yamashita; William H Westra; André Lopes Carvalho; Juna Lee; Wei-Wen Jiang; Jin Hyen Baek; Junwei Liu; Motonobu Osada; Chulso Moon; Joseph A Califano; Masaki Mori; David Sidransky
DCC promoter hypermethylation in esophageal squamous cell carcinoma.
International journal of cancer. Journal international du cancer 2008;122(11):2498-502.
2008: Huafeng Zhang; MARTA BOSCH; Larissa A Shimoda; Yee Sun Tan; Jin Hyen Baek; Jacob B Wesley; Frank J Gonzalez; Gregg L Semenza
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.
The Journal of biological chemistry 2008;283(16):10892-903.
2008: Myoung Sook Kim; Xiaofei Chang; JATIN NAGPAL; Keishi Yamashita; Jin Hyen Baek; S Dasgupta; Guojun Wu ; Motonobu Osada; J-H Woo; William H Westra; Barry Trink; Edward Ratovitski; Chulso Moon; David Sidransky
The N-methyl-D-aspartate receptor type 2A is frequently methylated in human colorectal carcinoma and suppresses cell growth.
Oncogene 2008;27(14):2045-54.
2008: Janghee Woo; Young Kwang Chae; Se Jin Jang; Myoung Sook Kim; Jin Hyen Baek; Jong Chul Park; Barry Trink; Edward Ratovitski; Taekyul Lee; Beomsoo Park; Minjoo Park; Ji Hye Kang; Jean Charles Soria; Juna Lee; Joseph A Califano; David Sidransky; Chulso Moon
Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium.
Biochemical and biophysical research communications 2008;366(2):321-7.
2007: Jin Hyen Baek; Ye V Liu; Karin R McDonald; Jacob B Wesley; Huafeng Zhang; Gregg L Semenza
Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.
The Journal of biological chemistry 2007;282(46):33358-66.
2007: Jin Hyen Baek; Ye V Liu; Karin R McDonald; Jacob B Wesley; Maimon E Hubbi; Hweejo Byun; Gregg L Semenza
Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha.
The Journal of biological chemistry 2007;282(32):23572-80.
2007: Ye V Liu; Jin Hyen Baek; Huafeng Zhang; roberto diez; Robert N Cole; Gregg L Semenza
RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha.
Molecular cell 2007;25(2):207-17.
2006: Myoung Sook Kim; Keishi Yamashita; Jin Hyen Baek; Hannah Lui Park; André Lopes Carvalho; Motonobu Osada; Mohammad Hoque; Sunil Upadhyay; Masaki Mori; Chulso Moon; David Sidransky
N-methyl-D-aspartate receptor type 2B is epigenetically inactivated and exhibits tumor-suppressive activity in human esophageal cancer.
Cancer research 2006;66(7):3409-18.
2006: Balaji Krishnamachary; David Zagzag; Hideko Nagasawa; Karin Rainey; Hiroaki Okuyama; Jin Hyen Baek; Gregg L Semenza
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.
Cancer research 2006;66(5):2725-31.
2006: Nathaniel Hwang; Myoung Sook Kim; Somponnat Sampattavanich; Jin Hyen Baek; Zijun Zhang; Jennifer H Elisseeff
Effects of three-dimensional culture and growth factors on the chondrogenic differentiation of murine embryonic stem cells.
Stem cells (Dayton, Ohio) 2006;24(2):284-91.
2005: Ho-Young Lee; Seung-Hyun Oh; Young-Ah Suh; Jin Hyen Baek; Vassiliki A Papadimitrakopoulou; Suyun Huang; Waun Ki Hong
Response of non-small cell lung cancer cells to the inhibitors of phosphatidylinositol 3-kinase/Akt- and MAPK kinase 4/c-Jun NH2-terminal kinase pathways: an effective therapeutic strategy for lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(16):6065-74.
2005: Myoung Sook Kim; Jin Hyen Baek; Jeong Ae Park; Bang Yeon Hwang; Se Eun Kim; Jung Joon Lee; Kyu-Won Kim
Wilfoside K1N isolated from Cynanchum wilfordii inhibits angiogenesis and tumor cell invasion.
International journal of oncology 2005;26(6):1533-9.
2005: Myoung Sook Kim; Jin Hyen Baek; Devulapalli Chakravarty; David Sidransky; France Carrier
Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA).
Experimental cell research 2005;306(1):94-102.
2005: Jin Hyen Baek; Patrick C Mahon; Jane Oh; Brian Kelly; Balaji Krishnamachary; Mia Pearson; Denise A Chan; Amato J Giaccia; Gregg L Semenza
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
Molecular cell 2005;17(4):503-12.
2003: Myoung Sook Kim; Mellissa Blake; Jin Hyen Baek; Glenda Kohlhagen; Yves Pommier; France Carrier
Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA.
Cancer research 2003;63(21):7291-300.
2001: MS Kim; H J Kwon; You Mie Lee; Jin Hyen Baek; J E Jang; Sae-Won Lee; Eun-Joung Moon; Heui-Soo Kim; Seok-Ki Lee; Hae Young Chung; Chul Woo Kim; Kyu-Won Kim
Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes.
Nature medicine 2001;7(4):437-43.
2001: MS Kim; Jin Hyen Baek; MT Park; T K Sohn; S E Kim; J J Lee; Kyu-Won Kim
Anti-invasive activity of torilin, a sesquiterpene compound isolated from Torilis japonica.
Oncology reports 2001;8(2):359-64.
2001: S H Park; K W Kim; Y S Lee; Jin Hyen Baek; Myoung Sook Kim; Y M Lee; M S Lee; Y J Kim
Hypoglycemia-induced VEGF expression is mediated by intracellular Ca2+ and protein kinase C signaling pathway in HepG2 human hepatoblastoma cells.
International journal of molecular medicine 2001;7(1):91-6.
2000: Jin Hyen Baek; J E Jang; C M Kang; Hae Young Chung; Nam Deuk Kim; Kyu-Won Kim
Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis.
Oncogene 2000;19(40):4621-31.
2000: Yung Hyun Choi; Jin Hyen Baek; M A Yoo; H Y Chung; Nam Deuk Kim; K W Kim
Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells.
International journal of oncology 2000;17(3):565-71.
2000: Dong-Kyoo Kim; Jin Hyen Baek; C M Kang; M A Yoo; Jae-Wook Sung; H Y Chung; Nam Deuk Kim; Y H Choi; S H Lee; K W Kim
Apoptotic activity of ursolic acid may correlate with the inhibition of initiation of DNA replication.
International journal of cancer. Journal international du cancer 2000;87(5):629-36.
1998: Soo-Kyung Bae; Jin Hyen Baek; You Mie Lee; Ok-Hee Lee; Kyu-Won Kim
Hypoxia-induced apoptosis in human hepatocellular carcinoma cells: a possible involvement of the 6-TG-sensitive protein kinase(s)-dependent signaling pathway.
Cancer letters 1998;126(1):97-104.
1997: Jin Hyen Baek; Y S Lee; C M Kang; J A Kim; K S Kwon; Han Chul Son; Kyu-Won Kim
Intracellular Ca2+ release mediates ursolic acid-induced apoptosis in human leukemic HL-60 cells.
International journal of cancer. Journal international du cancer 1997;73(5):725-8.
1997: Y H Park; J A Kim; Jin Hyen Baek; E J Jung; T H Kim; Hongsuk Suh; M H Park; Kyu-Won Kim
Induction of apoptosis in HepG2 human hepatocellular carcinoma cells by a novel derivative of ursodeoxycholic acid (UDCA).
Archives of pharmacal research 1997;20(1):29-33.