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Michael Kastan

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Michael B Kastan
A message from the Editor-in-Chief.
Yiting Lim; William Matsui; Akil A Merchant; Hsiang-Hsuan M Yu; YONGGANG ZHANG; Mohammad Hedayati; Michael B Kastan; Theodore L DeWeese
Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation.
Jing Chen; Kexiao Guo; Michael B Kastan
Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA.

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All Publications

2012: Michael B Kastan
A message from the Editor-in-Chief.
Molecular cancer research : MCR 2012;10(12):1513.
2012: Yiting Lim; William Matsui; Akil A Merchant; Hsiang-Hsuan M Yu; YONGGANG ZHANG; Mohammad Hedayati; Michael B Kastan; Theodore L DeWeese
Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation.
International journal of radiation oncology, biology, physics 2012;84(3):800-6.
2012: Jing Chen; Kexiao Guo; Michael B Kastan
Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA.
The Journal of biological chemistry 2012;287(20):16467-76.
2012: Yasmine A Valentin-Vega; Michael B Kastan
A new role for ATM: regulating mitochondrial function and mitophagy.
Autophagy 2012;8(5):840-1.
2012: Babak Razani; Jenny P Ting; Herbert W Virgin; Haitao Wen; Trey Coleman; Roy Emanuel; Chu Feng; Seungmin Hwang; Michael B Kastan; Clay F Semenkovich
Autophagy links inflammasomes to atherosclerotic progression.
Cell metabolism 2012;15(4):534-44.
2012: Yasmine A Valentin-Vega; John L Cleveland; Frank C Dorsey; Douglas R Green; Kirsteen H Maclean; Sandra Milasta; Meredith Steeves; Jacqueline Tait-Mulder; Michael B Kastan
Mitochondrial dysfunction in ataxia-telangiectasia.
Blood 2012;119(6):1490-500.
2010: Jing Chen; Michael B Kastan
5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage.
Genes & development 2010;24(19):2146-56.
2010: Frederick A Derheimer; Michael B Kastan
Multiple roles of ATM in monitoring and maintaining DNA integrity.
FEBS letters 2010;584(17):3675-81.
2010: Wing Leung; Geoffrey Neale; Frederick G. Behm; Rekha Iyengar; David Finkelstein; Michael B Kastan; Ching-Hon Pui
Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemia.
Cancer epidemiology 2010;34(3):303-8.
2010: Md Hasan Zaki; Kelli L Boyd; Peter Vogel; Michael B Kastan; Mohamed Lamkanfi; Thirumala-Devi Kanneganti
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.
Immunity 2010;32(3):379-91.
2010: Angela Alexander; Sheng-Li Cai; Jinhee Kim; Adrian Nanez; Mustafa Sahin; Kirsteen H Maclean; Ken Inoki; Kun-Liang Guan; Jianjun Shen; Maria D Person; Donna F Kusewitt; Gordon B Mills; Michael B Kastan; Cheryl Lyn Walker
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(9):4153-8.
2008: Yaara Ofir-Rosenfeld; Kristy Boggs; Dan Michael; Michael B Kastan; Moshe Oren
Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26.
Molecular cell 2008;32(2):180-9.
2008: Michael D Rainey; Maura E Charlton; Robert V Stanton; Michael B Kastan
Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation.
Cancer research 2008;68(18):7466-74.
2008: Chandtip Chandhasin; Razvan I Ducu; Elijahu Berkovich; Michael B Kastan; Susan J Marriott
Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response.
Journal of virology 2008;82(14):6952-61.
2008: Michael B Kastan
DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture.
Molecular cancer research : MCR 2008;6(4):517-24.
2008: Xi Tang; Zhou-Guang Hui; Xiao-Li Cui; Renu Garg; Michael B Kastan; Bo Xu
A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage.
Molecular and cellular biology 2008;28(8):2559-66.
2008: Elijahu Berkovich; Raymond J Monnat; Michael B Kastan
Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites.
Nature protocols 2008;3(5):915-22.
2008: Kirsteen H Maclean; Frank C Dorsey; John L Cleveland; Michael B Kastan
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.
The Journal of clinical investigation 2008;118(1):79-88.
2007: Christian R Loehberg; Tiia Thompson; Michael B Kastan; Kirsteen H Maclean; Dean G Edwards; Frances S Kittrell; Daniel Medina; Orla M Conneely; Bert W O'Malley
Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis.
Cancer research 2007;67(24):12026-33.
2007: Michael B Kastan
Our cells get stressed too! Implications for human disease.
Blood cells, molecules & diseases 2007;39(2):148-50.
2007: Kirsteen H Maclean; Michael B Kastan; John L Cleveland
Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis.
Molecular cancer research : MCR 2007;5(7):705-11.
2007: Elijahu Berkovich; Raymond J Monnat; Michael B Kastan
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair.
Nature cell biology 2007;9(6):683-90.
2007: Michael B Kastan; Elijahu Berkovich
p53: a two-faced cancer gene.
Nature cell biology 2007;9(5):489-91.
2007: Michael B Kastan
Wild-type p53: tumors can't stand it.
Cell 2007;128(5):837-40.
2006: Jochen G Schneider; Brian N Finck; Jie Ren; Kara N Standley; Masatoshi Takagi; Kirsteen H Maclean; Carlos Bernal-Mizrachi; Anthony J Muslin; Michael B Kastan; Clay F Semenkovich
ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome.
Cell metabolism 2006;4(5):377-89.
2006: John T Sandlund; Michael B Kastan; Wren Kennedy; Frederick G. Behm; Elaine Entrekin; Ching-Hon Pui; David T Kalwinsky; Susana C Raimondi
A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia.
Cancer genetics and cytogenetics 2006;168(1):69-72.
2006: Simon Bekker-Jensen; Claudia Lukas; Risa Kitagawa; Fredrik Melander; Michael B Kastan; Jiri Bartek; Jiri Lukas
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.
The Journal of cell biology 2006;173(2):195-206.
2005: Monica Morales; Jan-Willem F Theunissen; Carla F. Kim; Risa Kitagawa; Michael B Kastan; John H J Petrini
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.
Genes & development 2005;19(24):3043-54.
2005: Michael B Kastan
Cell biology: A BID for the pathway.
Nature 2005;437(7062):1103.
2005: Masatoshi Takagi; Michael J Absalon; Kevin G McLure; Michael B Kastan
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
Cell 2005;123(1):49-63.
2005: Jirina Bartkova; Christopher J Bakkenist; Ewa Rajpert-De Meyts; Niels E Skakkebaek; Maxwell Sehested; Jiri Lukas; Michael B Kastan; Jiri Bartek
ATM activation in normal human tissues and testicular cancer.
Cell cycle (Georgetown, Tex.) 2005;4(6):838-45.
2005: Risa Kitagawa; Michael B Kastan
The ATM-dependent DNA damage signaling pathway.
Cold Spring Harbor symposia on quantitative biology 2005;70():99-109.
2004: Michael B Kastan; Jiri Bartek
Cell-cycle checkpoints and cancer.
Nature 2004;432(7015):316-23.
2004: Kevin G McLure; Masatoshi Takagi; Michael B Kastan
NAD+ modulates p53 DNA binding specificity and function.
Molecular and cellular biology 2004;24(22):9958-67.
2004: Jan Karlseder; Kristina Hoke; Olga K Mirzoeva; Christopher J Bakkenist; Michael B Kastan; John H J Petrini; Titia de Lange
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.
PLoS biology 2004;2(8):E240.
2004: Martin F Arlt; Bo Xu; Sandra G Durkin; Anne M Casper; Michael B Kastan; Thomas W Glover
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function.
Molecular and cellular biology 2004;24(15):6701-9.
2004: Christopher J Bakkenist; Michael B Kastan
Initiating cellular stress responses.
Cell 2004;118(1):9-17.
2004: Christopher J Bakkenist; Michael B Kastan
Phosphatases join kinases in DNA-damage response pathways.
Trends in cell biology 2004;14(7):339-41.
2004: Jordi Surrallés; Stephen P Jackson; Maria Jasin; Michael B Kastan; Stephen C West; Hans Joenje
Molecular cross-talk among chromosome fragility syndromes.
Genes & development 2004;18(12):1359-70.
2004: Risa Kitagawa; Christopher J Bakkenist; Peter J McKinnon; Michael B Kastan
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.
Genes & development 2004;18(12):1423-38.
2004: Renu Garg; Shannon Callens; Dae-Sik Lim; Shilpy Sharma; Michael B Kastan; Bo Xu
Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation.
Molecular cancer research : MCR 2004;2(6):362-9.
2004: Christopher J Bakkenist; Rachid Drissi; Jing Wu; Michael B Kastan; Jeffrey S Dome
Disappearance of the telomere dysfunction-induced stress response in fully senescent cells.
Cancer research 2004;64(11):3748-52.
2004: Zuzana Horejsí; Jacob Falck; Christopher J Bakkenist; Michael B Kastan; Jiri Lukas; Jiri Bartek
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation.
Oncogene 2004;23(17):3122-7.
2004: Bo Xu; Michael B Kastan
Analyzing cell cycle checkpoints after ionizing radiation.
Methods in molecular biology (Clifton, N.J.) 2004;281():283-92.
2003: ML Cortés; Christopher J Bakkenist; M V Di Maria; Michael B Kastan; Xandra O Breakefield
HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.
Gene therapy 2003;10(16):1321-7.
2003: Joo Hyeon Lee; Bo Xu; Chang-Hun Lee; Jun-Young Ahn; Min Sup Song; Ho Lee; Shilpy Sharma; Jong-Soo Lee; Michael B Kastan; Dae-Sik Lim
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
Molecular cancer research : MCR 2003;1(9):674-81.
2003: Christopher J Bakkenist; Michael B Kastan
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
Nature 2003;421(6922):499-506.
2003: Michael B Kastan; Gerard P Zambetti
Parc-ing p53 in the cytoplasm.
Cell 2003;112(1):1-2.
2002: Koji Nakanishi; Toshiyasu Taniguchi; Velvizhi Ranganathan; Helen V New; Lisa A Moreau; Maria Stotsky; Christopher G Mathew; Michael B Kastan; David Weaver; Alan D D'Andrea
Interaction of FANCD2 and NBS1 in the DNA damage response.
Nature cell biology 2002;4(12):913-20.
2002: Bo Xu; Anne H O'Donnell; Seong-Tae Kim; Michael B Kastan
Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.
Cancer research 2002;62(16):4588-91.
2002: Toshiyasu Taniguchi; Irene Garcia-Higuera; Bo Xu; Paul R Andreassen; Richard C. Gregory; Seong-Tae Kim; William Stratton Lane; Michael B Kastan; Alan D D'Andrea
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.
Cell 2002;109(4):459-72.
2002: Seong-Tae Kim; Bo Xu; Michael B Kastan
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage.
Genes & development 2002;16(5):560-70.
2002: Bo Xu; Seong-Tae Kim; Dae-Sik Lim; Michael B Kastan
Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation.
Molecular and cellular biology 2002;22(4):1049-59.
2001: Bo Xu; Michael B Kastan
Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation.
Molecular and cellular biology 2001;21(10):3445-50.
2001: Michael B Kastan; Dae-Sik Lim; Seong-Tae Kim; D Yang
ATM--a key determinant of multiple cellular responses to irradiation.
Acta oncologica (Stockholm, Sweden) 2001;40(6):686-8.
2001: Yosef Shiloh; Michael B Kastan
ATM: genome stability, neuronal development, and cancer cross paths.
Advances in cancer research 2001;83():209-54.
2000: D Q Yang; Michael B Kastan
Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.
Nature cell biology 2000;2(12):893-8.
2000: Dae-Sik Lim; Seong-Tae Kim; Bo Xu; richard s maser; J Lin; John H J Petrini; Michael B Kastan
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway.
Nature 2000;404(6778):613-7.
2000: Tej K Pandita; Howard B Lieberman; D S Lim; S Dhar; W Zheng; Y Taya; Michael B Kastan
Ionizing radiation activates the ATM kinase throughout the cell cycle.
Oncogene 2000;19(11):1386-91.
2000: Michael B Kastan; Dae-Sik Lim; Seong-Tae Kim; Bo Xu; Shilpy Sharma
Multiple signaling pathways involving ATM.
Cold Spring Harbor symposia on quantitative biology 2000;65():521-6.
2000: Yehiel Ziv; S Banin; D S Lim; Shilpy Sharma; Michael B Kastan; Yosef Shiloh
Expression and assay of recombinant ATM.
Methods in molecular biology (Clifton, N.J.) 2000;99():99-108.
1999: Seong-Tae Kim; Dae-Sik Lim; Shilpy Sharma; Michael B Kastan
Substrate specificities and identification of putative substrates of ATM kinase family members.
The Journal of biological chemistry 1999;274(53):37538-43.
1999: Joseph A DiGiuseppe; Li-Jun Weng; Kenneth Yu; S Fu; Michael B Kastan; D Samid; Steven D Gore
Phenylbutyrate-induced G1 arrest and apoptosis in myeloid leukemia cells: structure-function analysis.
Leukemia 1999;13(8):1243-53.
1999: Joseph A DiGiuseppe; Michael B Kastan; Li-Jun Weng; Steven D Gore
Cytoprotective effects of hematopoietic growth factors on primary human acute myeloid leukemias are not mediated through changes in BCL-2, bax, or p21WAF1/CIP1.
In vivo (Athens, Greece) 1999;13(1):1-6.
1998: CH Westphal; Kathryn P Hoyes; Shilpy Sharma; X Huang; Michael B Kastan; J H Hendry; Philip Leder
Loss of atm radiosensitizes multiple p53 null tissues.
Cancer research 1998;58(24):5637-9.
1998: Nelson Rhodes; T D'Souza; C D Foster; Yehiel Ziv; D G Kirsch; Yosef Shiloh; Michael B Kastan; Peter H Reinhart; Tona M Gilmer
Defective potassium currents in ataxia telangiectasia fibroblasts.
Genes & development 1998;12(23):3686-92.
1998: Shilpy Sharma; Dae-Sik Lim; Karlene A Cimprich; Y Taya; Katsuyuki Tamai; K Sakaguchi; E Appella; Michael B Kastan; Janet D Siliciano
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.
Science (New York, N.Y.) 1998;281(5383):1677-9.
1998: D G Kirsch; Michael B Kastan
Tumor-suppressor p53: implications for tumor development and prognosis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(9):3158-68.
1998: Dae-Sik Lim; D G Kirsch; Shilpy Sharma; JIN HYUN AHN; Yehiel Ziv; L S Newman; R B Darnell; Yosef Shiloh; Michael B Kastan
ATM binds to beta-adaptin in cytoplasmic vesicles.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10146-51.
1998: Shilpy Sharma; Michael B Kastan
Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis.
Oncogene 1998;16(8):957-66.
1997: Janet D Siliciano; Shilpy Sharma; Y Taya; K Sakaguchi; E Appella; Michael B Kastan
DNA damage induces phosphorylation of the amino terminus of p53.
Genes & development 1997;11(24):3471-81.
1997: Lubomir B Smilenov; SE Morgan; W Mellado; SG Sawant; Michael B Kastan; Tej K Pandita
Influence of ATM function on telomere metabolism.
Oncogene 1997;15(22):2659-65.
1997: Faton H Agani; D G Kirsch; S L Friedman; Michael B Kastan; Gregg L Semenza
p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene.
Cancer research 1997;57(20):4474-7.
1997: Su M Metcalfe; Shilpy Sharma; J Milner; R E Morris; S Goldman; Michael B Kastan
Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.
Oncogene 1997;15(14):1635-42.
1997: SE Morgan; Michael B Kastan
Dissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint.
Cancer research 1997;57(16):3386-9.
1997: R Baskaran; L D Wood; LL Whitaker; Shilpy Sharma; SE Morgan; Y Xu; C Barlow; David Baltimore; A Wynshaw-Boris; Michael B Kastan; Jean Y J Wang
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation.
Nature 1997;387(6632):516-9.
1997: Joseph A DiGiuseppe; Michael B Kastan
Apoptosis in haematological malignancies.
Journal of clinical pathology 1997;50(5):361-4.
1997: SE Morgan; C Lovly; Tej K Pandita; Y Shiloh; Michael B Kastan
Fragments of ATM which have dominant-negative or complementing activity.
Molecular and cellular biology 1997;17(4):2020-9.
1997: Shilpy Sharma; Michael B Kastan
Role of p53 in apoptosis.
Advances in pharmacology (San Diego, Calif.) 1997;41():429-60.
1997: SE Morgan; Michael B Kastan
p53 and ATM: cell cycle, cell death, and cancer.
Advances in cancer research 1997;71():1-25.
1996: Shilpy Sharma; Michael B Kastan
Signal transduction. Three paths to stress relief.
Nature 1996;384(6606):213-4.
1996: Tej K Pandita; Eric J Hall; Tom K Hei; M A Piatyszek; W E Wright; Chang Q Piao; Raj K Pandita; James Willey; Charles R Geard; Michael B Kastan; J W Shay
Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny.
Oncogene 1996;13(7):1423-30.
1996: C Y Chen; I Hall; T J Lansing; Tona M Gilmer; Thea D Tlsty; Michael B Kastan
Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate.
Cancer research 1996;56(16):3659-62.
1996: T Inaba; T Inukai; T Yoshihara; H Seyschab; R A Ashmun; Shilpy Sharma; S J Laken; Michael B Kastan; A Thomas Look
Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor.
Nature 1996;382(6591):541-4.
1996: S C Goldman; C Y Chen; T J Lansing; Tona M Gilmer; Michael B Kastan
The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization.
The American journal of pathology 1996;148(5):1381-5.
1995: Katherine E Kilpatrick; France Carrier; Martin L Smith; C Y Chen; A J Lee; D W Rusnak; Michael B Kastan; A J Fornace; BR Champion; Tona M Gilmer
The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein.
Hybridoma 1995;14(4):355-9.
1995: Shilpy Sharma; Tona M Gilmer; S B Coutts; Michael B Kastan
Growth factor modulation of p53-mediated growth arrest versus apoptosis.
Genes & development 1995;9(5):600-11.
1995: Michael B Kastan; Shilpy Sharma; C J Leonard
P53, cell cycle control and apoptosis: implications for cancer.
Cancer metastasis reviews 1995;14(1):3-15.
1995: Shilpy Sharma; Michael B Kastan
Induction of apoptosis by tumor suppressor genes and oncogenes.
Seminars in cancer biology 1995;6(1):17-25.
1995: C J Leonard; Shilpy Sharma; Michael B Kastan
The role of p53 in cell-cycle control and apoptosis: implications for cancer.
Important advances in oncology 1995;():33-42.
1994: ML Smith; I T Chen; Qimin Zhan; I Bae; C Y Chen; Tona M Gilmer; Michael B Kastan; Patrick M O'Connor; Albert J Fornace
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
Science (New York, N.Y.) 1994;266(5189):1376-80.
1994: Shilpy Sharma; Antonio C Wolff; C Y Chen; Albert J Fornace; Michael B Kastan
The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.
Cancer research 1994;54(19):5054-8.
1994: R J Slebos; M H Lee; B S Plunkett; T D Kessis; Bart Williams; Tyler Jacks; L Hedrick; Michael B Kastan; Kathleen R Cho
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5320-4.
1994: Qimin Zhan; I Bae; Michael B Kastan; Albert J Fornace
The p53-dependent gamma-ray response of GADD45.
Cancer research 1994;54(10):2755-60.
1994: C Y Chen; J D Oliner; Qimin Zhan; A J Fornace; Bert Vogelstein; Michael B Kastan
Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2684-8.
1994: William G Nelson; Michael B Kastan
DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.
Molecular and cellular biology 1994;14(3):1815-23.
1994: Shilpy Sharma; C Y Chen; M H Lee; Michael B Kastan
DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis.
Cold Spring Harbor symposia on quantitative biology 1994;59():277-86.
1993: Michael B Kastan; S J Kuerbitz
Control of G1 arrest after DNA damage.
Environmental health perspectives 1993;101 Suppl 5():55-8.
1993: W J Slichenmyer; William G Nelson; R J Slebos; Michael B Kastan
Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.
Cancer research 1993;53(18):4164-8.
1993: Ruth W Craig; H L Buchan; Curt I Civin; Michael B Kastan
Altered cytoplasmic/nuclear distribution of the c-myc protein in differentiating ML-1 human myeloid leukemia cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(5):349-57.
1993: T D Kessis; R J Slebos; William G Nelson; Michael B Kastan; B S Plunkett; S M Han; A T Lorincz; L Hedrick; Kathleen R Cho
Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):3988-92.
1992: Michael B Kastan; Qimin Zhan; Wafik S El-Deiry; France Carrier; Tyler Jacks; W V Walsh; B S Plunkett; Bert Vogelstein; Albert J Fornace
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.
Cell 1992;71(4):587-97.
1992: S J Kuerbitz; B S Plunkett; W V Walsh; Michael B Kastan
Wild-type p53 is a cell cycle checkpoint determinant following irradiation.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7491-5.
1991: Michael B Kastan; O Onyekwere; David Sidransky; Bert Vogelstein; Ruth W Craig
Participation of p53 protein in the cellular response to DNA damage.
Cancer research 1991;51(23 Pt 1):6304-11.
1991: Michael B Kastan; A I Radin; S J Kuerbitz; O Onyekwere; C A Wolkow; Curt I Civin; K D Stone; T Woo; Yaddanapudi Ravindranath; Ruth W Craig
Levels of p53 protein increase with maturation in human hematopoietic cells.
Cancer research 1991;51(16):4279-86.
1991: Scott H Kaufmann; S J McLaughlin; Michael B Kastan; L F Liu; Judith E Karp; P J Burke
Topoisomerase II levels during granulocytic maturation in vitro and in vivo.
Cancer research 1991;51(13):3534-43.
1991: Steven D Gore; Michael B Kastan; Curt I Civin
Normal human bone marrow precursors that express terminal deoxynucleotidyl transferase include T-cell precursors and possible lymphoid stem cells.
Blood 1991;77(8):1681-90.
1990: Steven D Gore; Michael B Kastan; Steven Goodman; Curt I Civin
Detection of minimal residual T cell acute lymphoblastic leukemia by flow cytometry.
Journal of immunological methods 1990;132(2):275-86.
1990: Steven D Gore; Michael B Kastan; Curt I Civin
Flow cytometric identification of intracellular antigens: detection of minimal residual leukemia.
Bone marrow transplantation 1990;6 Suppl 1():39-41.
1990: Michael B Kastan; E Schlaffer; J E Russo; O Michael Colvin; Curt I Civin; John Hilton
Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells.
Blood 1990;75(10):1947-50.
1989: Michael B Kastan; K D Stone; Curt I Civin
Nuclear oncoprotein expression as a function of lineage, differentiation stage, and proliferative status of normal human hematopoietic cells.
Blood 1989;74(5):1517-24.
1989: Michael B Kastan; Dennis J Slamon; Curt I Civin
Expression of protooncogene c-myb in normal human hematopoietic cells.
Blood 1989;73(6):1444-51.
1989: Michael B Kastan; L C Strauss; Curt I Civin
The role of hematopoietic growth factors and oncogenes in leukemogenesis.
The American journal of pediatric hematology/oncology 1989;11(3):249-67.
1989: Michael B Kastan; B A Zehnbauer; B G Leventhal; B J Corden; George J Dover
Philadelphia-chromosome positive essential thrombocythemia. Two cases in children.
The American journal of pediatric hematology/oncology 1989;11(4):433-6.