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Robert Kastelein

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Jonathan P Sherlock; Scott P Turner; Jennifer H Yearley; Edward P Bowman; Christopher D Buckley; Cheng-Chi Chao; Gérard Eberl; Daniel M Gorman; Jeff Grein; Barbara Joyce-Shaikh; Robert A Kastelein; Drake M Laface; Terrill K McClanahan; Robert H Pierce; Manjiri Sathe; Daniel J Cua
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells.
Corinne Cayatte; Smiley Chen; Daniel J Cua; Charles O Elson; William A Faubion; Jeffrey Grein; Barbara Joyce-Shaikh; Robert A Kastelein; Rene de Waal Malefyt; Maria-Christina Malinao; Terrill K McClanahan; Brent S McKenzie; Erin Murphy; Robert H Pierce; Felix Vega; Beth Basham; Wendy M Blumenschein; Katia Boniface; Edward P Bowman; Maribel Beaumont
Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease.
Steven A Saenz; Mark C Siracusa; Jacqueline G Perrigoue; Sean P Spencer; Joseph F Urban; Joel E Tocker; Alison L Budelsky; Melanie A Kleinschek; Robert A Kastelein; Taku Kambayashi; Avinash Bhandoola; David Artis
IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses.

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All Publications

2012: Jonathan P Sherlock; Scott P Turner; Jennifer H Yearley; Edward P Bowman; Christopher D Buckley; Cheng-Chi Chao; Gérard Eberl; Daniel M Gorman; Jeff Grein; Barbara Joyce-Shaikh; Robert A Kastelein; Drake M Laface; Terrill K McClanahan; Robert H Pierce; Manjiri Sathe; Daniel J Cua
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells.
Nature medicine 2012;18(7):1069-76.
2012: Corinne Cayatte; Smiley Chen; Daniel J Cua; Charles O Elson; William A Faubion; Jeffrey Grein; Barbara Joyce-Shaikh; Robert A Kastelein; Rene de Waal Malefyt; Maria-Christina Malinao; Terrill K McClanahan; Brent S McKenzie; Erin Murphy; Robert H Pierce; Felix Vega; Beth Basham; Wendy M Blumenschein; Katia Boniface; Edward P Bowman; Maribel Beaumont
Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease.
Clinical and translational gastroenterology 2012;3():e10.
2010: Steven A Saenz; Mark C Siracusa; Jacqueline G Perrigoue; Sean P Spencer; Joseph F Urban; Joel E Tocker; Alison L Budelsky; Melanie A Kleinschek; Robert A Kastelein; Taku Kambayashi; Avinash Bhandoola; David Artis
IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses.
Nature 2010;464(7293):1362-6.
2010: Andrew L Rankin; John B Mumm; Erin Murphy; Scott Turner; Ni Yu; Terrill McClanahan; Patricia A Bourne; Robert H Pierce; Robert A Kastelein; Stefan Pflanz
IL-33 induces IL-13-dependent cutaneous fibrosis.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1526-35.
2010: Melanie A Kleinschek; Uwe Müller; Nicole Schütze; Robert Sabat; Reinhard Straubinger; Wendy M Blumenschein; Terrill McClanahan; Robert A Kastelein; Gottfried Alber
Administration of IL-23 engages innate and adaptive immune mechanisms during fungal infection.
International immunology 2010;22(2):81-90.
2009: Caroline Diveu; Mandy J McGeachy; Katia Boniface; Jason S Stumhofer; Manjiri Sathe; Barbara Joyce-Shaikh; Yi Chen; Cristina M Tato; Terrill McClanahan; Rene de Waal Malefyt; Christopher A Hunter; Daniel J Cua; Robert A Kastelein
IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(9):5748-56.
2009: Katia Boniface; Kristian S Bak-Jensen; Ying Li; Wendy M Blumenschein; Mandy J McGeachy; Terrill McClanahan; Brent S McKenzie; Robert A Kastelein; Daniel J Cua; Rene de Waal Malefyt
Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
The Journal of experimental medicine 2009;206(3):535-48.
2009: Melanie A Kleinschek; Katia Boniface; Svetlana Sadekova; Jeff Grein; Erin E Murphy; Scott P Turner; Lisa Raskin; Bela Desai; William A Faubion; Rene de Waal Malefyt; Robert H Pierce; Terrill McClanahan; Robert A Kastelein
Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation.
The Journal of experimental medicine 2009;206(3):525-34.
2008: Silke M Schulz; Gabriele Köhler; Nicole Schütze; Jens Knauer; Reinhard Straubinger; Alissa A Chackerian; Ellen Witte; Kerstin Wolk; Robert Sabat; Yoichiro Iwakura; Christoph Holscher; Uwe Müller; Robert A Kastelein; Gottfried Alber
Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):7891-901.
2008: Colby Zaph; Yurong Du; Steven A Saenz; Meera G Nair; Jacqueline G Perrigoue; Betsy C Taylor; Amy E Troy; Dmytro E Kobuley; Robert A Kastelein; Daniel J Cua; Yimin Yu; David Artis
Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine.
The Journal of experimental medicine 2008;205(10):2191-8.
2007: Nicholas J Wilson; Katia Boniface; Jason R Chan; Brent S McKenzie; Wendy M Blumenschein; Jeanine D Mattson; Beth Basham; Kathleen Smith; Taiying Chen; Franck Morel; Jean-Claude Lecron; Robert A Kastelein; Daniel J Cua; Terrill McClanahan; Edward P Bowman; Rene de Waal Malefyt
Development, cytokine profile and function of human interleukin 17-producing helper T cells.
Nature immunology 2007;8(9):950-7.
2007: Alissa A Chackerian; Elizabeth Oldham; Erin E Murphy; Jochen Schmitz; Stefan Pflanz; Robert A Kastelein
IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2551-5.
2007: John L Langowski; Robert A Kastelein; Martin Oft
Swords into plowshares: IL-23 repurposes tumor immune surveillance.
Trends in immunology 2007;28(5):207-12.
2007: Jens Knauer; Sabine Siegemund; Uwe Müller; Samiya Al-Robaiy; Robert A Kastelein; Gottfried Alber; Reinhard Straubinger
Borrelia burgdorferi potently activates bone marrow-derived conventional dendritic cells for production of IL-23 required for IL-17 release by T cells.
FEMS immunology and medical microbiology 2007;49(3):353-63.
2007: Melanie A Kleinschek; Alexander M Owyang; Barbara Joyce-Shaikh; Claire L Langrish; Yi Chen; Daniel M Gorman; Wendy M Blumenschein; Terrill McClanahan; Frank Brombacher; Stephen D Hurst; Robert A Kastelein; Daniel J Cua
IL-25 regulates Th17 function in autoimmune inflammation.
The Journal of experimental medicine 2007;204(1):161-70.
2007: Robert A Kastelein; Christopher A Hunter; Daniel J Cua
Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation.
Annual review of immunology 2007;25():221-42.
2006: Jason R Chan; Wendy M Blumenschein; Erin Murphy; Caroline Diveu; Maria T Wiekowski; Susan L Abbondanzo; Linda Lucian; Richard Geissler; Scott J Brodie; Alexa B Kimball; Daniel M Gorman; Kathleen Smith; Rene de Waal Malefyt; Robert A Kastelein; Terrill McClanahan; Edward P Bowman
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis.
The Journal of experimental medicine 2006;203(12):2577-87.
2006: Alissa A Chackerian; Shi-Juan Chen; Scott J Brodie; Jeanine D Mattson; Terrill McClanahan; Robert A Kastelein; Edward P Bowman
Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection.
Infection and immunity 2006;74(11):6092-9.
2006: John L Langowski; Xueqing Zhang; Lingling Wu; Jeanine D Mattson; Taiying Chen; Kathy Smith; Beth Basham; Terrill McClanahan; Robert A Kastelein; Martin Oft
IL-23 promotes tumour incidence and growth.
Nature 2006;442(7101):461-5.
2006: Frédérique Larousserie; Emilie Bardel; Aurore Coulomb-L'Herminé; D Canioni; Nicole Brousse; Robert A Kastelein; Odile Devergne
Variable expression of Epstein-Barr virus-induced gene 3 during normal B-cell differentiation and among B-cell lymphomas.
The Journal of pathology 2006;209(3):360-8.
2006: Daniel J Cua; Robert A Kastelein
TGF-beta, a 'double agent' in the immune pathology war.
Nature immunology 2006;7(6):557-9.
2006: Frédérique Larousserie; Pascaline Charlot; Emilie Bardel; Josy Froger; Robert A Kastelein; Odile Devergne
Differential effects of IL-27 on human B cell subsets.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):5890-7.
2006: Yi Chen; Claire L Langrish; Brent S McKenzie; Barbara Joyce-Shaikh; Jason S Stumhofer; Terrill McClanahan; Wendy M Blumenschein; Tatyana Churakovsa; Justin Low; Leonard Presta; Christopher A Hunter; Robert A Kastelein; Daniel J Cua
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis.
The Journal of clinical investigation 2006;116(5):1317-26.
2006: David Yen; Jeanne Cheung; Heleen Scheerens; Frédérique Poulet; Terrill McClanahan; Brent S McKenzie; Melanie A Kleinschek; Alexander M Owyang; Jeanine D Mattson; Wendy M Blumenschein; Erin Murphy; Manjiri Sathe; Daniel J Cua; Robert A Kastelein; Donna Rennick
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.
The Journal of clinical investigation 2006;116(5):1310-6.
2006: Willem W Overwijk; Karin E de Visser; Felicia H Tirion; Laurina A de Jong; Thijs W H Pols; Yme U van der Velden; Jasper G van den Boorn; Anna M Keller; Wim A Buurman; Marc R Theoret; Bianca Blom; Nicholas P Restifo; Ada M Kruisbeek; Robert A Kastelein; John B A G Haanen
Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5213-22.
2006: Alexander M Owyang; Colby Zaph; Emma H Wilson; Katherine J Guild; Terrill McClanahan; Hugh Miller; Daniel J Cua; Michael H Goldschmidt; Christopher A Hunter; Robert A Kastelein; David Artis
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract.
The Journal of experimental medicine 2006;203(4):843-9.
2006: Melanie A Kleinschek; Uwe Müller; Scott J Brodie; Werner Stenzel; Gabriele Kohler; Wendy M Blumenschein; Reinhard Straubinger; Terrill McClanahan; Robert A Kastelein; Gottfried Alber
IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(2):1098-106.
2006: Alejandro V Villarino; Jason S Stumhofer; Christiaan J M Saris; Robert A Kastelein; Frederic J de Sauvage; Christopher A Hunter
IL-27 limits IL-2 production during Th1 differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):237-47.
2006: Brent S McKenzie; Robert A Kastelein; Daniel J Cua
Understanding the IL-23-IL-17 immune pathway.
Trends in immunology 2006;27(1):17-23.
2005: Jochen Schmitz; Alexander M Owyang; Elizabeth Oldham; Yaoli Song; Erin Murphy; Terrill McClanahan; Gerard Zurawski; Mehrdad Moshrefi; Jinzhong Qin; Xiaoxia Li; Daniel M Gorman; J. Fernando Bazan; Robert A Kastelein
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.
Immunity 2005;23(5):479-90.
2005: Frédérique Larousserie; Emilie Bardel; Stefan Pflanz; Bertrand Arnulf; Carmen Lome-Maldonado; Olivier Hermine; Laurence Brégeaud; Monique Perennec; Nicole Brousse; Robert A Kastelein; Odile Devergne
Analysis of interleukin-27 (EBI3/p28) expression in Epstein-Barr virus- and human T-cell leukemia virus type 1-associated lymphomas: heterogeneous expression of EBI3 subunit by tumoral cells.
The American journal of pathology 2005;166(4):1217-28.
2005: Claire L Langrish; Yi Chen; Wendy M Blumenschein; Jeanine D Mattson; Beth Basham; Jonathon D Sedgwick; Terrill McClanahan; Robert A Kastelein; Daniel J Cua
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation.
The Journal of experimental medicine 2005;201(2):233-40.
2004: Claire L Langrish; Brent S McKenzie; Nicholas J Wilson; Rene de Waal Malefyt; Robert A Kastelein; Daniel J Cua
IL-12 and IL-23: master regulators of innate and adaptive immunity.
Immunological reviews 2004;202():96-105.
2004: Linda A Lieberman; Fabiola Cardillo; Alexander M Owyang; Donna Rennick; Daniel J Cua; Robert A Kastelein; Christopher A Hunter
IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1887-93.
2004: Frank A W Verreck; Tjitske de Boer; Dennis M L Langenberg; Marieke A Hoeve; Matthijs Kramer; Elena Vaisberg; Robert A Kastelein; Arend H J Kolk; Rene de Waal Malefyt; Tom H M Ottenhoff
Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4560-5.
2004: Stefan Pflanz; Linda Hibbert; Jeanine D Mattson; Rency Rosales; Elena Vaisberg; J. Fernando Bazan; Joseph H Phillips; Terrill McClanahan; Rene de Waal Malefyt; Robert A Kastelein
WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2225-31.
2004: Frédérique Larousserie; Stefan Pflanz; Aurore Coulomb-L'Herminé; Nicole Brousse; Robert A Kastelein; Odile Devergne
Expression of IL-27 in human Th1-associated granulomatous diseases.
The Journal of pathology 2004;202(2):164-71.
2003: Craig Murphy; Claire L Langrish; Yi Chen; Wendy M Blumenschein; Terrill McClanahan; Robert A Kastelein; Jonathon D Sedgwick; Daniel J Cua
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation.
The Journal of experimental medicine 2003;198(12):1951-7.
2003: Alejandro V Villarino; Linda Hibbert; Linda A Lieberman; Emma Wilson; Tak Mak; Hiroki Yoshida; Robert A Kastelein; Christiaan J M Saris; Christopher A Hunter
The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.
Immunity 2003;19(5):645-55.
2003: Giorgio Trinchieri; Stefan Pflanz; Robert A Kastelein
The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses.
Immunity 2003;19(5):641-4.
2003: Linda Hibbert; Stefan Pflanz; Rene de Waal Malefyt; Robert A Kastelein
IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2003;23(9):513-22.
2003: Frank Brombacher; Robert A Kastelein; Gottfried Alber
Novel IL-12 family members shed light on the orchestration of Th1 responses.
Trends in immunology 2003;24(4):207-12.
2003: Daniel J Cua; Jonathan Sherlock; Yi Chen; Craig Murphy; Barbara Joyce; Brian W P Seymour; Linda Lucian; Wayne To; Sylvia Kwan; Tatyana Churakova; Sandra Zurawski; Maria T Wiekowski; sergio lira; Daniel Gorman; Robert A Kastelein; Jonathon D Sedgwick
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain.
Nature 2003;421(6924):744-8.
2002: Vassili Soumelis; Pedro A Reche; Holger Kanzler; Wei Yuan; Gina Edward; Bernhard Homey; Michel Gilliet; Steve Ho; Svetlana Antonenko; Antti Lauerma; Kathleen Smith; Daniel Gorman; Sandra Zurawski; Jon Abrams; Satish Menon; Terrill McClanahan; Rene de Waal-Malefyt Rd; J. Fernando Bazan; Robert A Kastelein; Yong-Jun Liu
Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.
Nature immunology 2002;3(7):673-80.
2002: Stefan Pflanz; Jacqueline Timans; Jeanne Cheung; Rency Rosales; Holger Kanzler; Jonathan Gilbert; Linda Hibbert; Tatyana Churakova; Marilyn Travis; Elena Vaisberg; Wendy M Blumenschein; Jeanine D Mattson; Janet L Wagner; Wayne To; Sandra Zurawski; Terrill McClanahan; Daniel M Gorman; J. Fernando Bazan; Rene de Waal Malefyt; Donna Rennick; Robert A Kastelein
IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.
Immunity 2002;16(6):779-90.
2002: Christi Parham; Madaline Chirica; Jacqueline Timans; Elena Vaisberg; Marilyn Travis; Jeanne Cheung; Stefan Pflanz; Rebecca Zhang; Komal P Singh; Felix Vega; Wayne To; Janet Wagner; Anne-Marie O'Farrell; Terrill McClanahan; Sandra Zurawski; Charles Hannum; Daniel Gorman; Donna Rennick; Robert A Kastelein; Rene de Waal Malefyt; Kevin W Moore
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5699-708.
2001: J E Sims; Martin J H Nicklin; J. Fernando Bazan; Jenny L Barton; S J Busfield; John E Ford; Robert A Kastelein; S Kumar; H Lin; Julio Jose Mulero; J Pan; Y Pan; D E Smith; Peter Young
A new nomenclature for IL-1-family genes.
Trends in immunology 2001;22(10):536-7.
2001: N Kadowaki; Steve Ho; Svetlana Antonenko; R W Malefyt; Robert A Kastelein; J. Fernando Bazan; Yong-Jun Liu
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
The Journal of experimental medicine 2001;194(6):863-9.
2001: Maggie Neighbors; X Xu; Franck J Barrat; S R Ruuls; Tatyana Churakova; R Debets; J. Fernando Bazan; Robert A Kastelein; JS Abrams; Anne O'Garra
A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production.
The Journal of experimental medicine 2001;194(3):343-54.
2001: R Debets; Jacqueline Timans; Bernhard Homey; Sandra Zurawski; T R Sana; S Lo; Janet Wagner; G Edwards; Theresa Clifford; Satish Menon; J. Fernando Bazan; Robert A Kastelein
Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1440-6.
2001: Pedro A Reche; Vassili Soumelis; Daniel M Gorman; Theresa Clifford; Marilyn Travis; Sandra Zurawski; J Johnston; Yong-Jun Liu; H Spits; Rene de Waal Malefyt; Robert A Kastelein; J. Fernando Bazan
Human thymic stromal lymphopoietin preferentially stimulates myeloid cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):336-43.
2001: Maria T Wiekowski; Michael W Leach; Ellen W Evans; Lee Sullivan; Shu-Cheng Chen; Galya Vassileva; J. Fernando Bazan; Daniel M Gorman; Robert A Kastelein; Satwant K Narula; sergio lira
Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7563-70.
2001: Joan K Brieland; Craig Jackson; Frederick Menzel; David Loebenberg; Anthony Cacciapuoti; Judith Halpern; S Hurst; Tony Muchamuel; R Debets; Robert A Kastelein; Tatyana Churakova; Jon Abrams; Roberta S Hare; Anne O'Garra
Cytokine networking in lungs of immunocompetent mice in response to inhaled Aspergillus fumigatus.
Infection and immunity 2001;69(3):1554-60.
2000: G Cai; Robert A Kastelein; Christopher A Hunter
Interleukin-18 (IL-18) enhances innate IL-12-mediated resistance to Toxoplasma gondii.
Infection and immunity 2000;68(12):6932-8.
2000: Joan K Brieland; Craig Jackson; S Hurst; David Loebenberg; Tony Muchamuel; R Debets; Robert A Kastelein; Tatyana Churakova; Jon Abrams; Roberta S Hare; Anne O'Garra
Immunomodulatory role of endogenous interleukin-18 in gamma interferon-mediated resolution of replicative Legionella pneumophila lung infection.
Infection and immunity 2000;68(12):6567-73.
2000: B Oppmann; RE Lesley; Bianca Blom; Jacqueline Timans; Y Xu; BE Hunte; Felix Vega; N Yu; J Wang; K Singh; F Zonin; Elena Vaisberg; Tatyana Churakova; M Liu; Daniel Gorman; Janet Wagner; Sandra Zurawski; Ying Liu; JS Abrams; Kevin W Moore; Donna Rennick; Rene de Waal Malefyt; Charles Hannum; J. Fernando Bazan; Robert A Kastelein
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
Immunity 2000;13(5):715-25.
2000: R Debets; Jacqueline Timans; T Churakowa; Sandra Zurawski; Rene de Waal Malefyt; Kevin W Moore; JS Abrams; Anne O'Garra; J. Fernando Bazan; Robert A Kastelein
IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):4950-6.
2000: T R Sana; R Debets; Jacqueline Timans; J. Fernando Bazan; Robert A Kastelein
Computational identification, cloning, and characterization of IL-1R9, a novel interleukin-1 receptor-like gene encoded over an unusually large interval of human chromosome Xq22.2-q22.3.
Genomics 2000;69(2):252-62.
2000: G Cai; T Radzanowski; Eric Villegas; Robert A Kastelein; Christopher A Hunter
Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2619-27.
1999: G Cai; Robert A Kastelein; Christopher A Hunter
IL-10 enhances NK cell proliferation, cytotoxicity and production of IFN-gamma when combined with IL-18.
European journal of immunology 1999;29(9):2658-65.
1999: N Patel; E C Brinkman-Van der Linden; S W Altmann; K Gish; S Balasubramanian; Jacqueline Timans; D Peterson; M P Bell; J. Fernando Bazan; A Varki; Robert A Kastelein
OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily.
The Journal of biological chemistry 1999;274(32):22729-38.
1999: W Walker; M Aste-Amezaga; Robert A Kastelein; Giorgio Trinchieri; Christopher A Hunter
IL-18 and CD28 use distinct molecular mechanisms to enhance NK cell production of IL-12-induced IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5894-901.
1998: F L Rock; Hardiman Gary; Jacqueline Timans; Robert A Kastelein; J. Fernando Bazan
A family of human receptors structurally related to Drosophila Toll.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):588-93.
1997: Christopher A Hunter; Jacqueline Timans; P Pisacane; Satish Menon; G Cai; W Walker; M Aste-Amezaga; R Chizzonite; J. Fernando Bazan; Robert A Kastelein
Comparison of the effects of interleukin-1 alpha, interleukin-1 beta and interferon-gamma-inducing factor on the production of interferon-gamma by natural killer.
European journal of immunology 1997;27(11):2787-92.
1997: Hardiman Gary; N A Jenkins; N G Copeland; D J Gilbert; DK Garcia; Susan Naylor; Robert A Kastelein; J. Fernando Bazan
Genetic structure and chromosomal mapping of MyD88.
Genomics 1997;45(2):332-9.
1997: D Robinson; K Shibuya; A Mui; F Zonin; E Murphy; T Sana; S B Hartley; Satish Menon; Robert A Kastelein; J. Fernando Bazan; Anne O'Garra
IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.
Immunity 1997;7(4):571-81.
1997: Hardiman Gary; Robert A Kastelein; J. Fernando Bazan
Isolation, characterization and chromosomal localization of human WNT10B.
Cytogenetics and cell genetics 1997;77(3-4):278-82.
1996: M J Guimarães; D Peterson; A Vicari; BG Cocks; N G Copeland; D J Gilbert; N A Jenkins; D A Ferrick; Robert A Kastelein; J. Fernando Bazan; Albert Zlotnik
Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism?
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15086-91.
1996: Hardiman Gary; F L Rock; S Balasubramanian; Robert A Kastelein; J. Fernando Bazan
Molecular characterization and modular analysis of human MyD88.
Oncogene 1996;13(11):2467-75.
1996: F L Rock; D Peterson; B C Weig; Robert A Kastelein; J. Fernando Bazan
Binding of leptin to the soluble ectodomain of recombinant leptin receptor: a kinetic analysis by surface plasmon resonance.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(12):748-50.
1996: F L Rock; S W Altmann; M van Heek; Robert A Kastelein; J. Fernando Bazan
The leptin haemopoietic cytokine fold is stabilized by an intrachain disulfide bond.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(12):649-52.
1996: N Patel; J M Herrman; Jacqueline Timans; Robert A Kastelein
Functional replacement of cytokine receptor extracellular domains by leucine zippers.
The Journal of biological chemistry 1996;271(48):30386-91.
1996: J Kennedy; D L Rossi; Sandra Zurawski; F Vega; Robert A Kastelein; J L Wagner; C H Hannum; Albert Zlotnik
Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(8):611-7.
1996: J. Fernando Bazan; Jacqueline Timans; Robert A Kastelein
A newly defined interleukin-1?
Nature 1996;379(6566):591.
1995: S W Altmann; Jacqueline Timans; F L Rock; J. Fernando Bazan; Robert A Kastelein
Expression and purification of a synthetic human obese gene product.
Protein expression and purification 1995;6(6):722-6.
1995: Marcus O Muench; Maria-Grazia Roncarolo; Satish Menon; Y Xu; Robert A Kastelein; Sandra Zurawski; C H Hannum; J Culpepper; F Lee; R Namikawa
FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver.
Blood 1995;85(4):963-72.
1995: S W Altmann; Robert A Kastelein
Rational design of a mouse granulocyte macrophage-colony-stimulating factor receptor antagonist.
The Journal of biological chemistry 1995;270(5):2233-40.
1995: S W Altmann; N Patel; Robert A Kastelein
Involvement of the fourth alpha-helix of mouse granulocyte-macrophage colony-stimulating factor in binding to the alpha-subunit of the receptor complex.
Growth factors (Chur, Switzerland) 1995;12(4):251-62.
1994: C Hannum; J Culpepper; D Campbell; Terrill McClanahan; Sandra Zurawski; J. Fernando Bazan; Robert A Kastelein; Susan Hudak; J Wagner; J Mattson
Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs.
Nature 1994;368(6472):643-8.
1993: Timothy Doherty; Robert A Kastelein; Satish Menon; S Andrade; Robert L Coffman
Modulation of murine macrophage function by IL-13.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):7151-60.
1993: Robert A Kastelein; A B Shanafelt
GM-CSF receptor: interactions and activation.
Oncogene 1993;8(2):231-6.
1992: A B Shanafelt; Robert A Kastelein
High affinity ligand binding is not essential for granulocyte-macrophage colony-stimulating factor receptor activation.
The Journal of biological chemistry 1992;267(35):25466-72.
1992: N J Meropol; S W Altmann; A B Shanafelt; Robert A Kastelein; G D Johnson; Michael B Prystowsky
Requirement of hydrophilic amino-terminal residues for granulocyte-macrophage colony-stimulating factor bioactivity and receptor binding.
The Journal of biological chemistry 1992;267(20):14266-9.
1992: F Rousset; E Garcia; T Defrance; C Péronne; N Vezzio; D H Hsu; Robert A Kastelein; Kevin W Moore; Jacques Banchereau
Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1890-3.
1991: A B Shanafelt; Atsushi Miyajima; T Kitamura; Robert A Kastelein
The amino-terminal helix of GM-CSF and IL-5 governs high affinity binding to their receptors.
The EMBO journal 1991;10(13):4105-12.
1991: Rene de Waal Malefyt; J Haanen; H Spits; M G Roncarolo; A te Velde; Carl Figdor; K Johnson; Robert A Kastelein; H Yssel; J E de Vries
Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.
The Journal of experimental medicine 1991;174(4):915-24.
1991: H Ishida; G Yang; N Harada; R L Hastings; B E Castle; Robert A Kastelein; Atsushi Miyajima; M Howard
Evaluation of murine interleukin 4 (IL-4) receptor expression using anti-receptor monoclonal antibodies and S1 nuclease protection analyses.
Cellular immunology 1991;136(1):142-54.
1991: A B Shanafelt; K E Johnson; Robert A Kastelein
Identification of critical amino acid residues in human and mouse granulocyte-macrophage colony-stimulating factor and their involvement in species specificity.
The Journal of biological chemistry 1991;266(21):13804-10.
1991: P Vieira; Rene de Waal Malefyt; M N Dang; K E Johnson; Robert A Kastelein; D F Fiorentino; J E deVries; M G Roncarolo; TR Mosmann; Kevin W Moore
Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1172-6.
1990: N F Go; B E Castle; R Barrett; Robert A Kastelein; W Dang; TR Mosmann; Kevin W Moore; M Howard
Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.
The Journal of experimental medicine 1990;172(6):1625-31.
1989: A B Shanafelt; Robert A Kastelein
Identification of critical regions in mouse granulocyte-macrophage colony-stimulating factor by scanning-deletion analysis.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):4872-6.
1988: H Spits; H Yssel; X Paliard; Robert A Kastelein; Carl Figdor; Jan E de Vries
IL-4 inhibits IL-2-mediated induction of human lymphokine-activated killer cells, but not the generation of antigen-specific cytotoxic T lymphocytes in mixed leukocyte cultures.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(1):29-36.
1987: T R Mosmann; T Yokota; Robert A Kastelein; Sandra Zurawski; N Arai; Y Takebe
Species-specificity of T cell stimulating activities of IL 2 and BSF-1 (IL 4): comparison of normal and recombinant, mouse and human IL 2 and BSF-1 (IL 4).
Journal of immunology (Baltimore, Md. : 1950) 1987;138(6):1813-6.