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Philippe Kastner

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Publications

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Philippe Kastner; Patrick Lutz; Arnaud Dupuis; Marie-Pierre Gaub; Raoul Herbrecht; Susan Chan
Function of Ikaros as a tumor suppressor in B cell acute lymphoblastic leukemia.
MacLean Sellars; Philippe Kastner; Susan Chan
Ikaros in B cell development and function.
Philippe Kastner; Susan Chan
Role of Ikaros in T-cell acute lymphoblastic leukemia.

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All Publications

2013: Philippe Kastner; Patrick Lutz; Arnaud Dupuis; Marie-Pierre Gaub; Raoul Herbrecht; Susan Chan
Function of Ikaros as a tumor suppressor in B cell acute lymphoblastic leukemia.
American journal of blood research 2013;3(1):1-13.
2011: MacLean Sellars; Philippe Kastner; Susan Chan
Ikaros in B cell development and function.
World journal of biological chemistry 2011;2(6):132-9.
2011: Philippe Kastner; Susan Chan
Role of Ikaros in T-cell acute lymphoblastic leukemia.
World journal of biological chemistry 2011;2(6):108-14.
2010: Robin Jeannet; Jérôme Mastio; Alejandra Macias-Garcia; Attila Oravecz; Todd Ashworth; Anne-Solen Geimer Le Lay; Bernard Jost; Stéphanie Le Gras; Jacques Ghysdael; Thomas Gridley; Tasuku Honjo; Freddy Radtke; Jon C Aster; Susan Chan; Philippe Kastner
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.
Blood 2010;116(25):5443-54.
2010: Philippe Kastner; Susan Chan; Walter K Vogel; Ling-Juan Zhang; Acharawan Topark-Ngarm; Olga Golonzhka; Bernard Jost; Stéphanie Le Gras; Michael K Gross; Mark Leid
Bcl11b represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytes.
European journal of immunology 2010;40(8):2143-54.
2010: Ambroise Marçais; Robin Jeannet; Lucie Hernandez; Jean Soulier; François Sigaux; Susan Chan; Philippe Kastner
Genetic inactivation of Ikaros is a rare event in human T-ALL.
Leukemia research 2010;34(4):426-9.
2009: Qi Cai; Andrée Dierich; Mustapha Oulad-Abdelghani; Susan Chan; Philippe Kastner
Helios deficiency has minimal impact on T cell development and function.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2303-11.
2009: MacLean Sellars; Bernardo Reina-San-Martin; Philippe Kastner; Susan Chan
Ikaros controls isotype selection during immunoglobulin class switch recombination.
The Journal of experimental medicine 2009;206(5):1073-87.
2008: Eva Kleinmann; Anne-Solen Geimer Le Lay; MacLean Sellars; Philippe Kastner; Susan Chan
Ikaros represses the transcriptional response to Notch signaling in T-cell development.
Molecular and cellular biology 2008;28(24):7465-75.
2008: Scott H Robbins; Thierry Walzer; Doulaye Dembélé; Christelle Thibault; Axel Defays; Gilles Bessou; Huichun Xu; Eric Vivier; MacLean Sellars; Philippe Pierre; Frank R Sharp; Susan Chan; Philippe Kastner; Marc Dalod
Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling.
Genome biology 2008;9(1):R17.
2008: Philippe Kastner; Susan Chan
PU.1: a crucial and versatile player in hematopoiesis and leukemia.
The international journal of biochemistry & cell biology 2008;40(1):22-7.
2006: David Allman; Marc Dalod; Carine Asselin-Paturel; Thomas Delale; Scott H Robbins; Giorgio Trinchieri; Christine A Biron; Philippe Kastner; Susan Chan
Ikaros is required for plasmacytoid dendritic cell differentiation.
Blood 2006;108(13):4025-34.
2006: Agnès Coste; Maria Cristina Antal; Susan Chan; Philippe Kastner; Manuel Mark; Bert W O'Malley; Johan Auwerx
Absence of the steroid receptor coactivator-3 induces B-cell lymphoma.
The EMBO journal 2006;25(11):2453-64.
2006: Alexis Dumortier; Robin Jeannet; Peggy Kirstetter; Eva Kleinmann; MacLean Sellars; Nuno R. dos Santos; Christelle Thibault; Jochen Barths; Jacques Ghysdael; Jennifer A Punt; Philippe Kastner; Susan Chan
Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice.
Molecular and cellular biology 2006;26(1):209-20.
2005: Thomas Delale; André Paquin; Carine Asselin-Paturel; Marc Dalod; Géraldine Brizard; Elizabeth E M Bates; Philippe Kastner; Susan Chan; Shizuo Akira; Alain P Vicari; Christine A Biron; Giorgio Trinchieri; Francine Brière
MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6723-32.
2005: Jonathan Back; David Allman; Susan Chan; Philippe Kastner
Visualizing PU.1 activity during hematopoiesis.
Experimental hematology 2005;33(4):395-402.
2004: Terrie-Anne Cock; Jonathan Back; Florent Elefteriou; Gerard Karsenty; Philippe Kastner; Susan Chan; Johan Auwerx
Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen.
EMBO reports 2004;5(10):1007-12.
2004: Jonathan Back; Andrée Dierich; Corinne Bronn; Philippe Kastner; Susan Chan
PU.1 determines the self-renewal capacity of erythroid progenitor cells.
Blood 2004;103(10):3615-23.
2003: Doulaye Dembélé; Philippe Kastner
Fuzzy C-means method for clustering microarray data.
Bioinformatics (Oxford, England) 2003;19(8):973-80.
2003: Alexis Dumortier; Peggy Kirstetter; Philippe Kastner; Susan Chan
Ikaros regulates neutrophil differentiation.
Blood 2003;101(6):2219-26.
2002: Peggy Kirstetter; Mireille Thomas; Andrée Dierich; Philippe Kastner; Susan Chan
Ikaros is critical for B cell differentiation and function.
European journal of immunology 2002;32(3):720-30.
2001: Philippe Kastner; S Chan
Function of RARalpha during the maturation of neutrophils.
Oncogene 2001;20(49):7178-85.
2001: Takeshi Imai; Ming Jiang; Philippe Kastner; Pierre Chambon; Daniel Metzger
Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4581-6.
2001: Philippe Kastner; H J Lawrence; C Waltzinger; Norbert B Ghyselinck; Pierre Chambon; Susan Chan
Positive and negative regulation of granulopoiesis by endogenous RARalpha.
Blood 2001;97(5):1314-20.
2000: V Subbarayan; Manuel Mark; N Messadeq; P Rustin; Pierre Chambon; Philippe Kastner
RXRalpha overexpression in cardiomyocytes causes dilated cardiomyopathy but fails to rescue myocardial hypoplasia in RXRalpha-null fetuses.
The Journal of clinical investigation 2000;105(3):387-94.
1999: Manuel Mark; Norbert B Ghyselinck; Olivia Wendling; Valérie Dupé; Bénédicte Mascrez; Philippe Kastner; Pierre Chambon
A genetic dissection of the retinoid signalling pathway in the mouse.
The Proceedings of the Nutrition Society 1999;58(3):609-13.
1999: Wojciech Krezel; Philippe Kastner; Pierre Chambon
Differential expression of retinoid receptors in the adult mouse central nervous system.
Neuroscience 1999;89(4):1291-300.
1998: Bénédicte Mascrez; Manuel Mark; Andrée Dierich; Norbert B Ghyselinck; Philippe Kastner; Pierre Chambon
The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development.
Development (Cambridge, England) 1998;125(23):4691-707.
1998: A C Barros; LC Erway; Wojciech Krezel; T Curran; Philippe Kastner; Pierre Chambon; Douglas Forrest
Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis.
Neuroreport 1998;9(13):2933-7.
1998: Wojciech Krezel; Norbert B Ghyselinck; Tarek A Samad; Valérie Dupé; Philippe Kastner; Emiliana Borrelli; Pierre Chambon
Impaired locomotion and dopamine signaling in retinoid receptor mutant mice.
Science (New York, N.Y.) 1998;279(5352):863-7.
1998: Manuel Mark; Norbert B Ghyselinck; Philippe Kastner; Valérie Dupé; Olivia Wendling; Wojciech Krezel; Bénédicte Mascrez; Pierre Chambon
Mesectoderm is a major target of retinoic acid action.
European journal of oral sciences 1998;106 Suppl 1():24-31.
1997: Philippe Kastner; Nadia Messaddeq; Manuel Mark; Olivia Wendling; J M Grondona; S Ward; Norbert B Ghyselinck; Pierre Chambon
Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes.
Development (Cambridge, England) 1997;124(23):4749-58.
1997: Vincent Sapin; Pascal Dollé; Colette Hindelang; Philippe Kastner; Pierre Chambon
Defects of the chorioallantoic placenta in mouse RXRalpha null fetuses.
Developmental biology 1997;191(1):29-41.
1997: V Subbarayan; Philippe Kastner; Manuel Mark; Andrée Dierich; P Gorry; Pierre Chambon
Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms.
Mechanisms of development 1997;66(1-2):131-42.
1997: Manuel Mark; Philippe Kastner; Norbert B Ghyselinck; Wojciech Krezel; Valérie Dupé; Pierre Chambon
[Genetic control of the development by retinoic acid].
Comptes rendus des séances de la Société de biologie et de ses filiales 1997;191(1):77-90.
1997: Philippe Kastner; Manuel Mark; Norbert B Ghyselinck; Wojciech Krezel; Valérie Dupé; J M Grondona; Pierre Chambon
Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development.
Development (Cambridge, England) 1997;124(2):313-26.
1996: Jacques Brocard; Philippe Kastner; Pierre Chambon
Two novel RXR alpha isoforms from mouse testis.
Biochemical and biophysical research communications 1996;229(1):211-8.
1996: Wojciech Krezel; Valérie Dupé; Manuel Mark; Andrée Dierich; Philippe Kastner; Pierre Chambon
RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9010-4.
1996: J M Grondona; Philippe Kastner; Anne Gansmuller; D Décimo; Pierre Chambon; Manuel Mark
Retinal dysplasia and degeneration in RARbeta2/RARgamma2 compound mutant mice.
Development (Cambridge, England) 1996;122(7):2173-88.
1996: Philippe Kastner; Manuel Mark; M Leid; Anne Gansmuller; W Chin; J M Grondona; D Décimo; Wojciech Krezel; Andrée Dierich; Pierre Chambon
Abnormal spermatogenesis in RXR beta mutant mice.
Genes & development 1996;10(1):80-92.
1995: Philippe Kastner; Manuel Mark; Pierre Chambon
Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?
Cell 1995;83(6):859-69.
1995: Manuel Mark; D Lohnes; C Mendelsohn; Valérie Dupé; Jean-Luc Vonesch; Philippe Kastner; Filippo M Rijli; A Bloch-Zupan; Pierre Chambon
Roles of retinoic acid receptors and of Hox genes in the patterning of the teeth and of the jaw skeleton.
The International journal of developmental biology 1995;39(1):111-21.
1994: Philippe Kastner; J M Grondona; Manuel Mark; Anne Gansmuller; Marianne LeMeur; D Decimo; Jean-Luc Vonesch; Pascal Dollé; Pierre Chambon
Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis.
Cell 1994;78(6):987-1003.
1994: Pascal Dollé; V Fraulob; Philippe Kastner; Pierre Chambon
Developmental expression of murine retinoid X receptor (RXR) genes.
Mechanisms of development 1994;45(2):91-104.
1993: A Perez; Philippe Kastner; S Sethi; Yves Lutz; C Reibel; Pierre Chambon
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR.
The EMBO journal 1993;12(8):3171-82.
1993: M Leid; Philippe Kastner; B Durand; A Krust; P Leroy; R Lyons; C Mendelsohn; S Nagpal; Harikrishna Nakshatri; C Reibel
Retinoic acid signal transduction pathways.
Annals of the New York Academy of Sciences 1993;684():19-34.
1993: D Lohnes; Philippe Kastner; Andrée Dierich; Manuel Mark; Marianne LeMeur; Pierre Chambon
Function of retinoic acid receptor gamma in the mouse.
Cell 1993;73(4):643-58.
1993: G Allenby; M T Bocquel; M Saunders; S Kazmer; J Speck; M Rosenberger; A Lovey; Philippe Kastner; J F Grippo; Pierre Chambon
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(1):30-4.
1992: M Leid; Philippe Kastner; Pierre Chambon
Multiplicity generates diversity in the retinoic acid signalling pathways.
Trends in biochemical sciences 1992;17(10):427-33.
1992: S Nagpal; M Saunders; Philippe Kastner; B Durand; Harikrishna Nakshatri; Pierre Chambon
Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors.
Cell 1992;70(6):1007-19.
1992: Philippe Kastner; A Perez; Yves Lutz; Cécile Rochette-Egly; M P Gaub; B Durand; Michel Lanotte; R Berger; Pierre Chambon
Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.
The EMBO journal 1992;11(2):629-42.
1992: M Leid; Philippe Kastner; R Lyons; Harikrishna Nakshatri; M Saunders; T Zacharewski; J Y Chen; Adrien Staub; Jean-Marie Garnier; S Mader
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.
Cell 1992;68(2):377-95.
1992: D Lohnes; Andrée Dierich; Norbert B Ghyselinck; Philippe Kastner; C Lampron; Marianne LeMeur; Thomas Lufkin; C Mendelsohn; Harikrishna Nakshatri; Pierre Chambon
Retinoid receptors and binding proteins.
Journal of cell science. Supplement 1992;16():69-76.
1991: Hinrich Gronemeyer; M E Meyer; M T Bocquel; Philippe Kastner; B Turcotte; Pierre Chambon
Progestin receptors: isoforms and antihormone action.
The Journal of steroid biochemistry and molecular biology 1991;40(1-3):271-8.
1991: Arthur Zelent; C Mendelsohn; Philippe Kastner; A Krust; Jean-Marie Garnier; F Ruffenach; P Leroy; Pierre Chambon
Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing.
The EMBO journal 1991;10(1):71-81.
1991: P Leroy; A Krust; Arthur Zelent; C Mendelsohn; Jean-Marie Garnier; Philippe Kastner; Andrée Dierich; Pierre Chambon
Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid.
The EMBO journal 1991;10(1):59-69.
1991: Philippe Kastner; A Perez; Yves Lutz; Cécile Rochette-Egly; M P Gaub; Pierre Chambon
[Fusion proteins between PML and alpha-RAR in acute promyelocytic leukemia].
Comptes rendus des séances de la Société de biologie et de ses filiales 1991;185(6):391-401.
1990: Philippe Kastner; M T Bocquel; B Turcotte; Jean-Marie Garnier; K B Horwitz; Pierre Chambon; Hinrich Gronemeyer
Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms.
The Journal of biological chemistry 1990;265(21):12163-7.
1990: Philippe Kastner; A Krust; B Turcotte; U Stropp; Làszlò Tora; Hinrich Gronemeyer; Pierre Chambon
Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.
The EMBO journal 1990;9(5):1603-14.
1990: Philippe Kastner; A Krust; C Mendelsohn; Jean-Marie Garnier; Arthur Zelent; P Leroy; Adrien Staub; Pierre Chambon
Murine isoforms of retinoic acid receptor gamma with specific patterns of expression.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2700-4.
1989: Pascal Dollé; E Ruberte; Philippe Kastner; Martin Petkovich; C M Stoner; L J Gudas; Pierre Chambon
Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse.
Nature 1989;342(6250):702-5.
1989: A Krust; Philippe Kastner; Martin Petkovich; Arthur Zelent; Pierre Chambon
A third human retinoic acid receptor, hRAR-gamma.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5310-4.
1989: Arthur Zelent; A Krust; Martin Petkovich; Philippe Kastner; Pierre Chambon
Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin.
Nature 1989;339(6227):714-7.