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Steinunn Baekkeskov

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Chemicals & Drugs

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Jamil Kanaani; Julia Kolibachuk; Hugo Martinez; Steinunn Baekkeskov
Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters.
Raya B Elagin; Sadguna Balijepalli; Maria J Diacovo; Steinunn Baekkeskov; Juan Carlos Jaume
Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice.
Steinunn Baekkeskov; Jamil Kanaani
Palmitoylation cycles and regulation of protein function (Review).

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All Publications

2010: Jamil Kanaani; Julia Kolibachuk; Hugo Martinez; Steinunn Baekkeskov
Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters.
The Journal of cell biology 2010;190(5):911-25.
2009: Raya B Elagin; Sadguna Balijepalli; Maria J Diacovo; Steinunn Baekkeskov; Juan Carlos Jaume
Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice.
Journal of autoimmunity 2009;33(1):50-7.
2009: Steinunn Baekkeskov; Jamil Kanaani
Palmitoylation cycles and regulation of protein function (Review).
Molecular membrane biology 2009;26(1):42-54.
2008: Jamil Kanaani; George Patterson; Fred Schaufele; Jennifer Lippincott-Schwartz; Steinunn Baekkeskov
A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes.
Journal of cell science 2008;121(Pt 4):437-49.
2005: Jamil Kanaani; Stanley B Prusiner; Julia Diacovo; Steinunn Baekkeskov; Giuseppe Legname
Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro.
Journal of neurochemistry 2005;95(5):1373-86.
2004: Jamil Kanaani; Maria Julia Diacovo; Alaa El-Husseini; David S Bredt; Steinunn Baekkeskov
Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters.
Journal of cell science 2004;117(Pt 10):2001-13.
2002: Jamil Kanaani; Alaa El-Husseini; Andrea Aguilera-Moreno; Julia M Diacovo; David S Bredt; Steinunn Baekkeskov
A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65.
The Journal of cell biology 2002;158(7):1229-38.
2002: N Hayakawa; L D K E Premawardhana; Michael Powell; M Masuda; Clare Arnold; Jane Sanders; M Evans; Shu Chen; Juan Carlos Jaume; Steinunn Baekkeskov; Bernard Rees Smith; Jadwiga Furmaniak
Isolation and characterization of human monoclonal autoantibodies to glutamic acid decarboxylase.
Autoimmunity 2002;35(5):343-55.
2002: Juan Carlos Jaume; Sarah Louise Parry; Anne-Marie Madec; Grete Sønderstrup; Steinunn Baekkeskov
Suppressive effect of glutamic acid decarboxylase 65-specific autoimmune B lymphocytes on processing of T cell determinants located within the antibody epitope.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):665-72.
2002: Tom Wolfe; Adrian Bot; Anna Hughes; Ursula Möhrle; Evelyn Rodrigo; Juan Carlos Jaume; Steinunn Baekkeskov; Matthias von Herrath
Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safety.
European journal of immunology 2002;32(1):113-21.
2000: Steinunn Baekkeskov; Jamil Kanaani; Juan Carlos Jaume; SF Kash
Does GAD have a unique role in triggering IDDM?
Journal of autoimmunity 2000;15(3):279-86.
2000: Y Shi; Jamil Kanaani; V Menard-Rose; Y H Ma; P Y Chang; Douglas Hanahan; A Tobin; G Grodsky; Steinunn Baekkeskov
Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion.
American journal of physiology. Endocrinology and metabolism 2000;279(3):E684-94.
2000: Sang-Mo Kang; D Braat; Darren B Schneider; Robert W O'rourke; Z Lin; Nancy L Ascher; David A Dichek; Steinunn Baekkeskov; Peter G Stock
A non-cleavable mutant of Fas ligand does not prevent neutrophilic destruction of islet transplants.
Transplantation 2000;69(9):1813-7.
2000: U Roll; C W Turck; Stephen E Gitelman; Stephen M Rosenthal; M S Nolte; Umesh Masharani; Anette-G Ziegler; Steinunn Baekkeskov
Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in Type I diabetic patients.
Diabetologia 2000;43(5):598-608.
2000: Robert W O'rourke; Sang-Mo Kang; J A Lower; Sandy Feng; Nancy L Ascher; Steinunn Baekkeskov; Peter G Stock
A dendritic cell line genetically modified to express CTLA4-IG as a means to prolong islet allograft survival.
Transplantation 2000;69(7):1440-6.
1999: Jamil Kanaani; DV Lissin; SF Kash; Steinunn Baekkeskov
The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65.
The Journal of biological chemistry 1999;274(52):37200-9.
1999: Ning Tian; C Petersen; SF Kash; Steinunn Baekkeskov; David R Copenhagen; Roger A Nicoll
The role of the synthetic enzyme GAD65 in the control of neuronal gamma-aminobutyric acid release.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12911-6.
1999: SF Kash; Brian G Condie; Steinunn Baekkeskov
Glutamate decarboxylase and GABA in pancreatic islets: lessons from knock-out mice.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1999;31(5):340-4.
1999: H L Schwartz; J M Chandonia; SF Kash; Jamil Kanaani; E Tunnell; A Domingo; Fred Cohen; J Paul Banga; Anne-Marie Madec; W Richter; Steinunn Baekkeskov
High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase.
Journal of molecular biology 1999;287(5):983-99.
1999: SF Kash; Laurence H Tecott; Clyde W Hodge; Steinunn Baekkeskov
Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1698-703.
1998: Takao K Hensch; Michela Fagiolini; Nobuko Mataga; Michael P Stryker; Steinunn Baekkeskov; SF Kash
Local GABA circuit control of experience-dependent plasticity in developing visual cortex.
Science (New York, N.Y.) 1998;282(5393):1504-8.
1997: SF Kash; R S Johnson; Laurence H Tecott; Jeffrey L Noebels; R D Mayfield; Douglas Hanahan; Steinunn Baekkeskov
Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):14060-5.
1997: Sang-Mo Kang; Darren B Schneider; Z Lin; Douglas Hanahan; David A Dichek; P G Stock; Steinunn Baekkeskov
Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction.
Nature medicine 1997;3(7):738-43.
1997: M Namchuk; L Lindsay; Christoph W Turck; Jamil Kanaani; Steinunn Baekkeskov
Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha.
The Journal of biological chemistry 1997;272(3):1548-57.
1996: K Syren; L Lindsay; B Stoehrer; K Jury; F Lühder; Steinunn Baekkeskov; W Richter
Immune reactivity of diabetes-associated human monoclonal autoantibodies defines multiple epitopes and detects two domain boundaries in glutamate decarboxylase.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):5208-14.
1996: Henk-Jan Aanstoot; Sang-Mo Kang; J Kim; L A Lindsay; U Roll; Mikael Knip; M Atkinson; P Mose-Larsen; Stephen Fey; J Ludvigsson; L Landin; J Bruining; N Maclaren; H K Akerblom; Steinunn Baekkeskov
Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes.
The Journal of clinical investigation 1996;97(12):2772-83.
1994: Henk-Jan Aanstoot; E Sigurdsson; M Jaffe; Y Shi; Stephan Christgau; Diederick Grobbee; G Jan Bruining; J L Molenaar; Albert Hofman; Steinunn Baekkeskov
Value of antibodies to GAD65 combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood population.
Diabetologia 1994;37(9):917-24.
1994: J Kim; M Namchuk; T Bugawan; Q Fu; M Jaffe; Y Shi; Henk-Jan Aanstoot; Christoph W Turck; Henry A Erlich; V Lennon; Steinunn Baekkeskov
Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.
The Journal of experimental medicine 1994;180(2):595-606.
1994: Y Shi; B Veit; Steinunn Baekkeskov
Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65.
The Journal of cell biology 1994;124(6):927-34.
1993: J Kim; W Richter; Henk-Jan Aanstoot; Y Shi; Q Fu; R Rajotte; G Warnock; Steinunn Baekkeskov
Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.
Diabetes 1993;42(12):1799-808.
1993: F Radvanyi; Stephan Christgau; Steinunn Baekkeskov; C Jolicoeur; Douglas Hanahan
Pancreatic beta cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: a potentially general technique for isolating physiologically representative cell lines.
Molecular and cellular biology 1993;13(7):4223-32.
1993: W Richter; Y Shi; Steinunn Baekkeskov
Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2832-6.
1993: Steinunn Baekkeskov; Henk-Jan Aanstoot; Q Fu; M Jaffe; J Kim; J Quan; W Richter; Y Shi
The glutamate decarboxylase and 38KD autoantigens in type 1 diabetes: aspects of structure and epitope recognition.
Autoimmunity 1993;15 Suppl():24-6.
1992: C J Møller; Stephan Christgau; M R Williamson; Ole D Madsen; Z P Niu; Elisabeth Bock; Steinunn Baekkeskov
Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas.
Molecular endocrinology (Baltimore, Md.) 1992;6(8):1332-42.
1992: Stephan Christgau; Henk-Jan Aanstoot; H Schierbeck; K Begley; S Tullin; K Hejnaes; Steinunn Baekkeskov
Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain.
The Journal of cell biology 1992;118(2):309-20.
1991: Stephan Christgau; H Schierbeck; Henk-Jan Aanstoot; L Aagaard; K Begley; Hans Kofod; K Hejnaes; Steinunn Baekkeskov
Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble.
The Journal of biological chemistry 1991;266(34):23516.
1991: Stephan Christgau; H Schierbeck; Henk-Jan Aanstoot; L Aagaard; K Begley; Hans Kofod; K Hejnaes; Steinunn Baekkeskov
Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble.
The Journal of biological chemistry 1991;266(31):21257-64.
1990: Steinunn Baekkeskov; Henk-Jan Aanstoot; Stephan Christgau; A Reetz; Michele Solimena; Marilia I Cascalho; Franco Folli; H Richter-Olesen; Pietro De Camilli; P D Camilli
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.
Nature 1990;347(6289):151-6.
1990: M R Christie; Daniel G Pipeleers; Ake Lernmark; Steinunn Baekkeskov
Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes.
The Journal of biological chemistry 1990;265(1):376-81.
1990: E Sigurdsson; Steinunn Baekkeskov
The 64-kDa beta cell membrane autoantigen and other target molecules of humoral autoimmunity in insulin-dependent diabetes mellitus.
Current topics in microbiology and immunology 1990;164():143-68.
1989: Steinunn Baekkeskov; G Warnock; M Christie; R V Rajotte; P M Larsen; Stephen Fey
Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen.
Diabetes 1989;38(9):1133-41.
1989: E J Schoenle; Eugen Boltshauser; Steinunn Baekkeskov; M Landin Olsson; Toni Torresani; A von Felten
Preclinical and manifest diabetes mellitus in young patients with Friedreich's ataxia: no evidence of immune process behind the islet cell destruction.
Diabetologia 1989;32(6):378-81.
1988: S Efrat; S Linde; Hans Kofod; D Spector; M Delannoy; S Grant; Douglas Hanahan; Steinunn Baekkeskov
Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9037-41.
1988: M Christie; M Landin-Olsson; G Sundkvist; G Dahlquist; Ake Lernmark; Steinunn Baekkeskov
Antibodies to a Mr-64,000 islet cell protein in Swedish children with newly diagnosed type 1 (insulin-dependent) diabetes.
Diabetologia 1988;31(8):597-602.
1988: Ake Lernmark; Helle Markholst; H Laursen; G Contreas; M Altieri; Steinunn Baekkeskov; R Herold; W Kastern; Ole D Madsen
[Spontaneous diabetes and diabetes induced by streptozotocin in the rat and mouse].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1988;():15-31.
1987: Ake Lernmark; S Li; Steinunn Baekkeskov; M Christie; Birgitte K Michelsen; J Ursing; M L Olsson; G Sundkvist
Islet-specific immune mechanisms.
Diabetes/metabolism reviews 1987;3(4):959-80.
1987: S Efrat; Steinunn Baekkeskov; D Lane; Douglas Hanahan
Coordinate expression of the endogenous p53 gene in beta cells of transgenic mice expressing hybrid insulin-SV40 T antigen genes.
The EMBO journal 1987;6(9):2699-704.
1987: Steinunn Baekkeskov; M Landin; J K Kristensen; S Srikanta; G J Bruining; T Mandrup-Poulsen; C de Beaufort; J S Soeldner; George S Eisenbarth; F Lindgren
Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes.
The Journal of clinical investigation 1987;79(3):926-34.
1986: I Gerling; Steinunn Baekkeskov; A Lernmark
Islet cell and 64K autoantibodies are associated with plasma IgG in newly diagnosed insulin-dependent diabetic children.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(12):3782-5.
1985: A Lernmark; Steinunn Baekkeskov; I Gerling; W Kastern; C Knutson; Birgitte K Michelsen
Immunological aspects of type 1 and 2 diabetes mellitus.
Advances in experimental medicine and biology 1985;189():107-27.
1985: Birgitte K Michelsen; Steinunn Baekkeskov; T Deufel; W Kastern; Hans Kofod; Ake Lernmark; Henrik Vissing
[Mechanism and genetic control of the autoimmune response directed against beta-pancreatic cells in insulin-dependent diabetes].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1985;():171-82.