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Sven Kathöfer

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Eberhard P Scholz; Nora Niemer; David Hassel; Edgar Zitron; Heinrich F Bürgers; Ramona Bloehs; Claudia Seyler; Daniel Scherer; Dierk Thomas; Sven Kathöfer; Hugo A Katus; Wolfgang A Rottbauer; Christoph A Karle
Biophysical properties of zebrafish ether-à-go-go related gene potassium channels.
J Gierten; Eckhard Ficker; Ramona Bloehs; K Schlömer; Sven Kathöfer; Eberhard P Scholz; Edgar Zitron; Claudia Seyler; Alexander Bauer; Ruediger Becker; Hugo A Katus; Christoph A Karle; Dierk Thomas
Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.
Daniel Scherer; Katharina von Löwenstern; Edgar Zitron; Eberhard P Scholz; Ramona Bloehs; Sven Kathöfer; Dierk Thomas; Alexander Bauer; Hugo A Katus; Christoph A Karle; Claudia Seyler
Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin.

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All Publications

2009: Eberhard P Scholz; Nora Niemer; David Hassel; Edgar Zitron; Heinrich F Bürgers; Ramona Bloehs; Claudia Seyler; Daniel Scherer; Dierk Thomas; Sven Kathöfer; Hugo A Katus; Wolfgang A Rottbauer; Christoph A Karle
Biophysical properties of zebrafish ether-à-go-go related gene potassium channels.
Biochemical and biophysical research communications 2009;381(2):159-64.
2008: J Gierten; Eckhard Ficker; Ramona Bloehs; K Schlömer; Sven Kathöfer; Eberhard P Scholz; Edgar Zitron; Claudia Seyler; Alexander Bauer; Ruediger Becker; Hugo A Katus; Christoph A Karle; Dierk Thomas
Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.
British journal of pharmacology 2008;154(8):1680-90.
2008: Daniel Scherer; Katharina von Löwenstern; Edgar Zitron; Eberhard P Scholz; Ramona Bloehs; Sven Kathöfer; Dierk Thomas; Alexander Bauer; Hugo A Katus; Christoph A Karle; Claudia Seyler
Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin.
Naunyn-Schmiedeberg's archives of pharmacology 2008;378(1):73-83.
2008: Dierk Thomas; Ramona Bloehs; Ronald Koschny; Eckhard Ficker; Jaromir Sykora; Johann Kiehn; Kathrin Schlömer; Jakob Gierten; Sven Kathöfer; Edgar Zitron; Eberhard P Scholz; Claudia Seyler; Hugo A Katus; Christoph A Karle
Doxazosin induces apoptosis of cells expressing hERG K+ channels.
European journal of pharmacology 2008;579(1-3):98-103.
2008: Edgar Zitron; Myriam Günth; Daniel Scherer; Claudia Seyler; Martin Kulzer; Ramona Bloehs; Eberhard P Scholz; Dierk Thomas; Christian Weidenhammer; Sven Kathöfer; Alexander Bauer; Hugo A Katus; Christoph A Karle
Kir2.x inward rectifier potassium channels are differentially regulated by adrenergic alpha1A receptors.
Journal of molecular and cellular cardiology 2008;44(1):84-94.
2007: Eberhard P Scholz; Franziska M Konrad; Daniel L Weiss; Edgar Zitron; Claudia Seyler; Ramona Bloehs; Martin Kulzer; Dierk Thomas; Sven Kathöfer; Alexander Bauer; Martin H Maurer; Gunnar Seemann; Hugo A Katus; Christoph A Karle
Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656.
Naunyn-Schmiedeberg's archives of pharmacology 2007;376(4):275-84.
2007: Eberhard P Scholz; Edgar Zitron; Claudia Seyler; Dierk Thomas; Sven Kathöfer; Jörg Kreuzer; Alexander Bauer; Hugo A Katus; Andrew Remppis; Christoph A Karle; Johannes Greten
Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2007;17(9):666-75.
2007: Daniel Scherer; Claudia Seyler; Martin Kulzer; Myriam Günth; Eberhard P Scholz; Sven Kathöfer; Dierk Thomas; Martin Maurer; Jörg Kreuzer; Alexander Bauer; Hugo A Katus; Christoph A Karle; Edgar Zitron
Activation of inwardly rectifying Kir2.x potassium channels by beta 3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2.
Naunyn-Schmiedeberg's archives of pharmacology 2007;375(5):311-22.
2006: Eberhard P Scholz; Markus Alter; Edgar Zitron; Claudia Seyler; Sven Kathöfer; Dierk Thomas; Volker A W Kreye; Jörg Kreuzer; Ruediger Becker; Hugo A Katus; Johannes Greten; Christoph A Karle
In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform.
Toxicology letters 2006;165(2):156-66.
2006: Claudia Seyler; Markus Alter; Sven Kathöfer; Edgar Zitron; Eberhard P Scholz; Dierk Thomas; Jörg Kreuzer; Hugo A Katus; Alexander Bauer; Christoph A Karle
Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels.
Naunyn-Schmiedeberg's archives of pharmacology 2006;373(3):212-20.
2006: Claudia Seyler; Edgar Zitron; Daniel Scherer; Sonja Lueck; Ramona Bloehs; Eberhard P Scholz; Marcus Pirot; Sven Kathöfer; Dierk Thomas; Volker A W Kreye; Johann Kiehn; Mathias M Borst; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1.
Journal of molecular medicine (Berlin, Germany) 2006;84(1):46-56.
2005: Edgar Zitron; Eberhard P Scholz; Claudia Seyler; M Pirot; Sven Kathöfer; Dierk Thomas; Johann Kiehn; Hugo A Katus; Ruediger Becker; Christoph A Karle
[Molecular basis of primary electrical heart diseases].
Herzschrittmachertherapie & Elektrophysiologie 2005;16(4):229-38.
2005: Dierk Thomas; Anna-Britt Wimmer; Christoph A Karle; Manuela Licka; Markus Alter; Markus Khalil; Herbert E Ulmer; Sven Kathöfer; Johann Kiehn; Hugo A Katus; Wolfgang Schoels; Michael Koenen; Joerg Zehelein
Dominant-negative I(Ks) suppression by KCNQ1-deltaF339 potassium channels linked to Romano-Ward syndrome.
Cardiovascular research 2005;67(3):487-97.
2005: Eberhard P Scholz; Edgar Zitron; Claudia Seyler; Sonja Lück; Dierk Thomas; Sven Kathöfer; Volker A W Kreye; Hugo A Katus; Johann Kiehn; Wolfgang Schoels; Christoph A Karle
Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation.
Naunyn-Schmiedeberg's archives of pharmacology 2005;371(6):516-25.
2005: Edgar Zitron; Eberhard P Scholz; Robert W Owen; Sonja Lück; Claudia Seyler; Dierk Thomas; Sven Kathöfer; Feraydoon Niroomand; Johann Kiehn; Volker A W Kreye; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
QTc prolongation by grapefruit juice and its potential pharmacological basis: HERG channel blockade by flavonoids.
Circulation 2005;111(7):835-8.
2004: Claudia Seyler; Edgar Zitron; Sonja Lück; Ramona Bloehs; Eberhard P Scholz; Sven Kathöfer; Dierk Thomas; Volker A W Kreye; Hugo A Katus; Wolfgang Schoels; Christoph A Karle; Johann Kiehn
Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action.
Naunyn-Schmiedeberg's archives of pharmacology 2004;370(6):423-35.
2004: Dierk Thomas; Kezhong Wu; Anna-Britt Wimmer; Edgar Zitron; Bettina C Hammerling; Sven Kathöfer; Sonja Lueck; Ramona Bloehs; Volker A W Kreye; Johann Kiehn; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by alpha(1A)-adrenoceptors.
Journal of molecular medicine (Berlin, Germany) 2004;82(12):826-37.
2004: Edgar Zitron; Claudia Seyler; Sonja Lück; Sven Kathöfer; Dierk Thomas; Volker A W Kreye; Johann Kiehn; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
Human cardiac inwardly rectifying current IKir2.2 is upregulated by activation of protein kinase A.
Cardiovascular research 2004;63(3):520-7.
2004: Edgar Zitron; Claudia Seyler; Eberhard P Scholz; Sonja Lück; Ramona Bloehs; Sven Kathöfer; Dierk Thomas; Johann Kiehn; Volker A W Kreye; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone.
Naunyn-Schmiedeberg's archives of pharmacology 2004;370(2):146-56.
2004: Dierk Thomas; Bettina C Hammerling; Kezhong Wu; Anna-Britt Wimmer; Eckhard Ficker; Glenn E Kirsch; Mary C Kochan; Barbara A Wible; Eberhard P Scholz; Edgar Zitron; Sven Kathöfer; Volker A W Kreye; Hugo A Katus; Wolfgang Schoels; Christoph A Karle; Johann Kiehn
Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action.
British journal of pharmacology 2004;142(3):485-94.
2003: Eberhard P Scholz; Edgar Zitron; Claudia Seyler; Sonja Lueck; Sven Kathöfer; Dierk Thomas; Slawomir Weretka; Simon Peth; Volker A W Kreye; Wolfgang Schoels; Hugo A Katus; Johann Kiehn; Christoph A Karle
Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine.
Naunyn-Schmiedeberg's archives of pharmacology 2003;368(5):404-14.
2003: Sven Kathöfer; Katja Röckl; Wei Zhang; Dierk Thomas; Hugo Katus; Johann Kiehn; Volker A W Kreye; Wolfgang Schoels; Christoph A Karle
Human beta(3)-adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein.
Naunyn-Schmiedeberg's archives of pharmacology 2003;368(2):119-26.
2003: Dierk Thomas; Wei Zhang; Kezhong Wu; Anna-Britt Wimmer; Bernd Gut; Gunnar Wendt-Nordahl; Sven Kathöfer; Volker A W Kreye; Hugo A Katus; Wolfgang Schoels; Johann Kiehn; Christoph A Karle
Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein.
Cardiovascular research 2003;59(1):14-26.
2003: Dierk Thomas; Bernd Gut; Syrus Karsai; Anna-Britt Wimmer; Kezhong Wu; Gunnar Wendt-Nordahl; Wei Zhang; Sven Kathöfer; Wolfgang Schoels; Hugo A Katus; Johann Kiehn; Christoph A Karle
Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen.
Naunyn-Schmiedeberg's archives of pharmacology 2003;368(1):41-8.
2003: Dierk Thomas; Kezhong Wu; Sven Kathöfer; Hugo A Katus; Wolfgang Schoels; Johann Kiehn; Christoph A Karle
The antipsychotic drug chlorpromazine inhibits HERG potassium channels.
British journal of pharmacology 2003;139(3):567-74.
2002: Christoph A Karle; Edgar Zitron; Wei Zhang; Gunnar Wendt-Nordahl; Sven Kathöfer; Dierk Thomas; Bernd Gut; Eberhard P Scholz; Christian F Vahl; Hugo A Katus; Johann Kiehn
Human cardiac inwardly-rectifying K+ channel Kir(2.1b) is inhibited by direct protein kinase C-dependent regulation in human isolated cardiomyocytes and in an expression system.
Circulation 2002;106(12):1493-9.
2002: Edgar Zitron; Christoph A Karle; Gunnar Wendt-Nordahl; Sven Kathöfer; Wei Zhang; Dierk Thomas; Slawomir Weretka; Johann Kiehn
Bertosamil blocks HERG potassium channels in their open and inactivated states.
British journal of pharmacology 2002;137(2):221-8.
2002: Daniela Roesch-Ely; Regina W von Einsiedel; Sven Kathöfer; Markus Schwaninger; Matthias Weisbrod
Myocarditis with quetiapine.
The American journal of psychiatry 2002;159(9):1607-8.
2002: Zhang Wei; Dierk Thomas; Christoph A Karle; Sven Kathöfer; Johannes Schenkel; Volker A W Kreye; Eckhard Ficker; Barbara A Wible; Johann Kiehn
Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line.
Chinese medical journal 2002;115(5):668-76.
2002: Christoph A Karle; Edgar Zitron; Wei Zhang; Sven Kathöfer; Wolfgang Schoels; Johann Kiehn
Rapid component I(Kr) of the guinea-pig cardiac delayed rectifier K(+) current is inhibited by beta(1)-adrenoreceptor activation, via cAMP/protein kinase A-dependent pathways.
Cardiovascular research 2002;53(2):355-62.
2001: Christoph A Karle; Volker A W Kreye; Dierk Thomas; Katja Röckl; Sven Kathöfer; Wei Zhang; Johann Kiehn
Antiarrhythmic drug carvedilol inhibits HERG potassium channels.
Cardiovascular research 2001;49(2):361-70.
2000: Sven Kathöfer; Wei Zhang; Christoph A Karle; Dierk Thomas; Wolfgang Schoels; Johann Kiehn
Functional coupling of human beta 3-adrenoreceptors to the KvLQT1/MinK potassium channel.
The Journal of biological chemistry 2000;275(35):26743-7.
1999: Dierk Thomas; Wei Zhang; Christoph A Karle; Sven Kathöfer; W Schöls; Wolfgang Kübler; Johann Kiehn
Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A.
The Journal of biological chemistry 1999;274(39):27457-62.