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John Katzenellenbogen

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Younghoon Kim; John A Katzenellenbogen; Sung Hoon Kim; Melikhan Tanyeri; Charles M Schroeder
Dendrimer probes for enhanced photostability and localization in fluorescence imaging.
Jatinder S Josan; John A Katzenellenbogen
Designer antiandrogens join the race against drug resistance.
Younghoon Kim; Dean Ferracane; John A Katzenellenbogen; Sung Hoon Kim; Charles M Schroeder
Specific labeling of zinc finger proteins using noncanonical amino acids and copper-free click chemistry.

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All Publications

2013: Younghoon Kim; John A Katzenellenbogen; Sung Hoon Kim; Melikhan Tanyeri; Charles M Schroeder
Dendrimer probes for enhanced photostability and localization in fluorescence imaging.
Biophysical journal 2013;104(7):1566-75.
2013: Jatinder S Josan; John A Katzenellenbogen
Designer antiandrogens join the race against drug resistance.
eLife 2013;2():e00692.
2012: Younghoon Kim; Dean Ferracane; John A Katzenellenbogen; Sung Hoon Kim; Charles M Schroeder
Specific labeling of zinc finger proteins using noncanonical amino acids and copper-free click chemistry.
Bioconjugate chemistry 2012;23(9):1891-901.
2012: Dexing Zeng; Dong Zhou; Karen L Wooley; Carmen S Dence; John A Katzenellenbogen; Nam S Lee; Yongjian Liu; Michael J Welch
64Cu Core-labeled nanoparticles with high specific activity via metal-free click chemistry.
ACS nano 2012;6(6):5209-19.
2011: Ramasamy Paulmurugan; Anobel Tamrazi; John A Katzenellenbogen; Tarik F Massoud; Sanjiv S Gambhir
In vitro and in vivo molecular imaging of estrogen receptor α and β homo- and heterodimerization: exploration of new modes of receptor regulation.
Molecular endocrinology (Baltimore, Md.) 2011;25(12):2029-40.
2011: Michael J McLachlan; John A Katzenellenbogen; Huimin Zhao
A new fluorescence complementation biosensor for detection of estrogenic compounds.
Biotechnology and bioengineering 2011;108(12):2794-803.
2011: John A Katzenellenbogen
The 2010 Philip S. Portoghese Medicinal Chemistry Lectureship: addressing the "core issue" in the design of estrogen receptor ligands.
Journal of medicinal chemistry 2011;54(15):5271-82.
2011: Simone Bertini; Andrea De Cupertinis; Carlotta Granchi; Barbara Bargagli; Tiziano Tuccinardi; Adriano Martinelli; Marco Macchia; Jillian Rebecca Gunther; Kathryn E Carlson; John A Katzenellenbogen; Filippo Minutolo
Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.
European journal of medicinal chemistry 2011;46(6):2453-62.
2011: Filippo Minutolo; Marco Macchia; Benita S Katzenellenbogen; John A Katzenellenbogen
Estrogen receptor β ligands: recent advances and biomedical applications.
Medicinal research reviews 2011;31(3):364-442.
2011: M Jeyakumar; Kathryn E Carlson; Jillian R Gunther; John A Katzenellenbogen
Exploration of dimensions of estrogen potency: parsing ligand binding and coactivator binding affinities.
The Journal of biological chemistry 2011;286(15):12971-82.
2010: Steven L Neese; Donna L Korol; John A Katzenellenbogen; Susan L Schantz
Impact of estrogen receptor alpha and beta agonists on delayed alternation in middle-aged rats.
Hormones and behavior 2010;58(5):878-90.
2010: Terry W Moore; Jillian R Gunther; John A Katzenellenbogen
Probing the topological tolerance of multimeric protein interactions: evaluation of an estrogen/synthetic ligand for FK506 binding protein conjugate.
Bioconjugate chemistry 2010;21(10):1880-9.
2010: Jae Hak Lee; Hai-Bing Zhou; Carmen S Dence; Kathryn E Carlson; Michael J Welch; John A Katzenellenbogen
Development of [F-18]fluorine-substituted Tanaproget as a progesterone receptor imaging agent for positron emission tomography.
Bioconjugate chemistry 2010;21(6):1096-104.
2010: Hai-Bing Zhou; Jae Hak Lee; Christopher G Mayne; Kathryn E Carlson; John A Katzenellenbogen
Imaging progesterone receptor in breast tumors: synthesis and receptor binding affinity of fluoroalkyl-substituted analogues of tanaproget.
Journal of medicinal chemistry 2010;53(8):3349-60.
2010: Karen J Kieser; Dong Wook Kim; Kathryn E Carlson; Benita S Katzenellenbogen; John A Katzenellenbogen
Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs).
Journal of medicinal chemistry 2010;53(8):3320-9.
2010: Sung Hoon Kim; Jillian R Gunther; John A Katzenellenbogen
Monitoring a coordinated exchange process in a four-component biological interaction system: development of a time-resolved terbium-based one-donor/three-acceptor multicolor FRET system.
Journal of the American Chemical Society 2010;132(13):4685-92.
2010: Terry W Moore; Christopher G Mayne; John A Katzenellenbogen
Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs).
Molecular endocrinology (Baltimore, Md.) 2010;24(4):683-95.
2010: Tze Howe Charn; Edison Tak-Bun Liu; Edmund C Chang; Yew Kok Lee; John A Katzenellenbogen; Benita S Katzenellenbogen
Genome-wide dynamics of chromatin binding of estrogen receptors alpha and beta: mutual restriction and competitive site selection.
Molecular endocrinology (Baltimore, Md.) 2010;24(1):47-59.
2009: Anna B Williams; Patrick T Weiser; Robert N Hanson; Jillian Rebecca Gunther; John A Katzenellenbogen
Synthesis of biphenyl proteomimetics as estrogen receptor-alpha coactivator binding inhibitors.
Organic letters 2009;11(23):5370-3.
2009: Michael Waibel; Karen J Kieser; Kathryn E Carlson; Fabio Stossi; Benita S Katzenellenbogen; John A Katzenellenbogen
Phenethyl pyridines with non-polar internal substituents as selective ligands for estrogen receptor beta.
European journal of medicinal chemistry 2009;44(9):3560-70.
2009: Michael Waibel; Meri De Angelis; Fabio Stossi; Karen J Kieser; Kathryn E Carlson; Benita S Katzenellenbogen; John A Katzenellenbogen
Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta.
European journal of medicinal chemistry 2009;44(9):3412-24.
2009: Andrew L LaFrate; Kathryn E Carlson; John A Katzenellenbogen
Steroidal bivalent ligands for the estrogen receptor: design, synthesis, characterization and binding affinities.
Bioorganic & medicinal chemistry 2009;17(10):3528-35.
2009: Dong Zhou; Haibing Zhou; Carl C Jenks; Jason S Lewis; John A Katzenellenbogen; Michael J Welch
Bromination from the macroscopic level to the tracer radiochemical level: (76)Br radiolabeling of aromatic compounds via electrophilic substitution.
Bioconjugate chemistry 2009;20(4):808-16.
2009: M Jeyakumar; John A Katzenellenbogen
A dual-acceptor time-resolved Föster resonance energy transfer assay for simultaneous determination of thyroid hormone regulation of corepressor and coactivator binding to the thyroid hormone receptor: Mimicking the cellular context of thyroid hormone action.
Analytical biochemistry 2009;386(1):73-8.
2009: Filippo Minutolo; Simone Bertini; Carlotta Granchi; Teresa Marchitiello; Giovanni Prota; Simona Rapposelli; Tiziano Tuccinardi; Adriano Martinelli; Jillian Rebecca Gunther; Kathryn E Carlson; John A Katzenellenbogen; Marco Macchia
Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta.
Journal of medicinal chemistry 2009;52(3):858-67.
2009: Byung Chul Lee; Carmen S Dence; Haibing Zhou; Ephraim E Parent; Michael J Welch; John A Katzenellenbogen
Fluorine-18 labeling and biodistribution studies on peroxisome proliferator-activated receptor-gamma ligands: potential positron emission tomography imaging agents.
Nuclear medicine and biology 2009;36(2):147-53.
2009: Jillian R Gunther; Yuhong Du; Eric Rhoden; Iestyn Lewis; Brian Revennaugh; Terry W Moore; Sung Hoon Kim; ray dingledine; Haian Fu; John A Katzenellenbogen
A set of time-resolved fluorescence resonance energy transfer assays for the discovery of inhibitors of estrogen receptor-coactivator binding.
Journal of biomolecular screening 2009;14(2):181-93.
2009: Farrokh Dehdashti; Joanne E Mortimer; Kathryn Trinkaus; Michael J Naughton; Matthew Ellis; John A Katzenellenbogen; Michael J Welch; Barry A Siegel
PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer.
Breast cancer research and treatment 2009;113(3):509-17.
2009: Bridget Trogden; Sung Hoon Kim; Shuyi Lee; John A Katzenellenbogen
Tethered indoles as functionalizable ligands for the estrogen receptor.
Bioorganic & medicinal chemistry letters 2009;19(2):485-8.
2009: Hai-Bing Zhou; Kathryn E Carlson; Fabio Stossi; Benita S Katzenellenbogen; John A Katzenellenbogen
Analogs of methyl-piperidinopyrazole (MPP): antiestrogens with estrogen receptor alpha selective activity.
Bioorganic & medicinal chemistry letters 2009;19(1):108-10.
2008: Andrew L LaFrate; Jillian Rebecca Gunther; Kathryn E Carlson; John A Katzenellenbogen
Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor.
Bioorganic & medicinal chemistry 2008;16(23):10075-84.
2008: Sung Hoon Kim; Jillian Rebecca Gunther; John A Katzenellenbogen
Nonclassical SNAPFL analogue as a Cy5 resonance energy transfer partner.
Organic letters 2008;10(21):4931-4.
2008: Alexander A Parent; Jillian Rebecca Gunther; John A Katzenellenbogen
Blocking estrogen signaling after the hormone: pyrimidine-core inhibitors of estrogen receptor-coactivator binding.
Journal of medicinal chemistry 2008;51(20):6512-30.
2008: Zeynep Madak-Erdogan; Karen J Kieser; Sung Hoon Kim; Barry S Komm; John A Katzenellenbogen; Benita S Katzenellenbogen
Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors.
Molecular endocrinology (Baltimore, Md.) 2008;22(9):2116-27.
2008: Dong Zhou; Terry L Sharp; Nicole M Fettig; Hsiaoju Lee; Jason S Lewis; John A Katzenellenbogen; Michael J Welch
Evaluation of a bromine-76-labeled progestin 16alpha,17alpha-dioxolane for breast tumor imaging and radiotherapy: in vivo biodistribution and metabolic stability studies.
Nuclear medicine and biology 2008;35(6):655-63.
2008: Rebecca Alyea; Stephanie E Laurence; Sung H Kim; Benita S Katzenellenbogen; John A Katzenellenbogen; Cheryl S Watson
The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells.
Journal of neurochemistry 2008;106(4):1525-33.
2008: M Jeyakumar; Paul Webb; John D Baxter; Thomas S Scanlan; John A Katzenellenbogen
Quantification of ligand-regulated nuclear receptor corepressor and coactivator binding, key interactions determining ligand potency and efficacy for the thyroid hormone receptor.
Biochemistry 2008;47(28):7465-76.
2008: Ramasamy Paulmurugan; Anobel Tamrazi; John A Katzenellenbogen; Benita S Katzenellenbogen; Sanjiv S Gambhir
A human estrogen receptor (ER)alpha mutation with differential responsiveness to nonsteroidal ligands: novel approaches for studying mechanism of ER action.
Molecular endocrinology (Baltimore, Md.) 2008;22(7):1552-64.
2008: Ephraim E Parent; Carmen S Dence; Terry L Sharp; Michael J Welch; John A Katzenellenbogen
7alpha-18F-fluoromethyl-dihydrotestosterone and 7alpha-18F-fluoromethyl-nortestosterone: ligands to determine the role of sex hormone-binding globulin for steroidal radiopharmaceuticals.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(6):987-94.
2008: Jillian Rebecca Gunther; Terry W Moore; Margaret L Collins; John A Katzenellenbogen
Amphipathic benzenes are designed inhibitors of the estrogen receptor alpha/steroid receptor coactivator interaction.
ACS chemical biology 2008;3(5):282-6.
2008: Edmund C Chang; Tze Howe Charn; Sung-Hee Park; William G Helferich; Barry S Komm; John A Katzenellenbogen; Benita S Katzenellenbogen
Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding.
Molecular endocrinology (Baltimore, Md.) 2008;22(5):1032-43.
2008: Kendall W. Nettles; John B Bruning; German Gil; Jason Nowak; Sanjay K Sharma; Johnnie Hahm; Kristen Kulp; Richard B Hochberg; Haibing Zhou; John A Katzenellenbogen; Benita S Katzenellenbogen; Younchang Kim; Andrzej Joachmiak; Geoffrey L Greene
NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.
Nature chemical biology 2008;4(4):241-7.
2008: Filippo Minutolo; R Bellini; Simone Bertini; Isabella Carboni; Annalina Lapucci; Letizia Pistolesi; Giovanni Prota; Simona Rapposelli; Francesca Solati; Tiziano Tuccinardi; Adriano Martinelli; Fabio Stossi; Kathryn E Carlson; Benita S Katzenellenbogen; John A Katzenellenbogen; Marco Macchia
Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor beta.
Journal of medicinal chemistry 2008;51(5):1344-51.
2008: Dong Wook Kim; Hwan-Jeong Jeong; Seok Tae Lim; Myung-Hee Sohn; John A Katzenellenbogen; Dae Yoon Chi
Facile nucleophilic fluorination reactions using tert-alcohols as a reaction medium: significantly enhanced reactivity of alkali metal fluorides and improved selectivity.
The Journal of organic chemistry 2008;73(3):957-62.
2008: Jai Woong Seo; Hee Jun Kim; Bon-Su Lee; John A Katzenellenbogen; Dae Yoon Chi
Convenient one-pot synthesis of 2,2-bis-(4-hydroxyphenyl)-cyclopentanone.
The Journal of organic chemistry 2008;73(2):715-8.
2007: Sung Hoon Kim; M Jeyakumar; John A Katzenellenbogen
Dual-mode fluorophore-doped nickel nitrilotriacetic acid-modified silica nanoparticles combine histidine-tagged protein purification with site-specific fluorophore labeling.
Journal of the American Chemical Society 2007;129(43):13254-64.
2007: Andrew L LaFrate; John A Katzenellenbogen
Improved chemical syntheses of 5,6-dihydro-5-fluorouracil.
The Journal of organic chemistry 2007;72(22):8573-6.
2007: Hai-Bing Zhou; Margaret L Collins; Jillian Rebecca Gunther; John S Comninos; John A Katzenellenbogen
Bicyclo[2.2.2]octanes: close structural mimics of the nuclear receptor-binding motif of steroid receptor coactivators.
Bioorganic & medicinal chemistry letters 2007;17(15):4118-22.
2007: Ephraim E Parent; Kathryn E Carlson; John A Katzenellenbogen
Synthesis of 7alpha-(fluoromethyl)dihydrotestosterone and 7alpha-(fluoromethyl)nortestosterone, structurally paired androgens designed to probe the role of sex hormone binding globulin in imaging androgen receptors in prostate tumors by positron emission tomography.
The Journal of organic chemistry 2007;72(15):5546-54.
2007: Hai-Bing Zhou; Kendall W. Nettles; John B Bruning; Younchang Kim; Andrzej Joachimiak; Sanjay Sharma; Kathryn E Carlson; Fabio Stossi; Benita S Katzenellenbogen; Geoffrey L Greene; John A Katzenellenbogen
Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands.
Chemistry & biology 2007;14(6):659-69.
2007: Jai Woong Seo; Dae Yoon Chi; Carmen S Dence; Michael J Welch; John A Katzenellenbogen
Synthesis and biodistribution of fluorine-18-labeled fluorocyclofenils for imaging the estrogen receptor.
Nuclear medicine and biology 2007;34(4):383-90.
2007: Ephraim E Parent; Carmen S Dence; Carl Jenks; Terry L Sharp; Michael J Welch; John A Katzenellenbogen
Synthesis and biological evaluation of [18F]bicalutamide, 4-[76Br]bromobicalutamide, and 4-[76Br]bromo-thiobicalutamide as non-steroidal androgens for prostate cancer imaging.
Journal of medicinal chemistry 2007;50(5):1028-40.
2007: Byung Chul Lee; Kyo Chul Lee; Hsiaoju Lee; Robert H Mach; John A Katzenellenbogen
Strategies for the labeling of halogen-substituted peroxisome proliferator-activated receptor gamma ligands: potential positron emission tomography and single photon emission computed tomography imaging agents.
Bioconjugate chemistry 2007;18(2):514-23.
2007: Byung Chul Lee; Kyo Chul Lee; Hsiaoju Lee; Robert H Mach; John A Katzenellenbogen
Synthesis and binding affinity of a fluorine-substituted peroxisome proliferator-activated gamma (PPARgamma) ligand as a potential positron emission tomography (PET) imaging agent.
Bioconjugate chemistry 2007;18(2):507-13.
2007: Hai-Bing Zhou; Shubin Sheng; Dennis R Compton; Younchang Kim; Andrzej Joachimiak; Sanjay Sharma; Kathryn E Carlson; Benita S Katzenellenbogen; Kendall W. Nettles; Geoffrey L Greene; John A Katzenellenbogen
Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains.
Journal of medicinal chemistry 2007;50(2):399-403.
2006: Varsha S Likhite; Fabio Stossi; Kyuri Kim; Benita S Katzenellenbogen; John A Katzenellenbogen
Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity.
Molecular endocrinology (Baltimore, Md.) 2006;20(12):3120-32.
2006: Sung Hoon Kim; John A Katzenellenbogen
Hormone-PAMAM dendrimer conjugates: polymer dynamics and tether structure affect ligand access to receptors.
Angewandte Chemie (International ed. in English) 2006;45(43):7243-8.
2006: Ephraim E Parent; Carl Jenks; Terry Sharp; Michael J Welch; John A Katzenellenbogen
Synthesis and biological evaluation of a nonsteroidal bromine-76-labeled androgen receptor ligand 3-[76Br]bromo-hydroxyflutamide.
Nuclear medicine and biology 2006;33(6):705-13.
2006: Dong Zhou; Kathryn E Carlson; John A Katzenellenbogen; Michael J Welch
Bromine- and iodine-substituted 16alpha,17alpha-dioxolane progestins for breast tumor imaging and radiotherapy: synthesis and receptor binding affinity.
Journal of medicinal chemistry 2006;49(15):4737-44.
2006: Ephraim E Parent; Carmen S Dence; Terry L Sharp; Michael J Welch; John A Katzenellenbogen
Synthesis and biological evaluation of a fluorine-18-labeled nonsteroidal androgen receptor antagonist, N-(3-[18F]fluoro-4-nitronaphthyl)-cis-5-norbornene-endo-2,3-dicarboxylic imide.
Nuclear medicine and biology 2006;33(5):615-24.
2006: Fabio Stossi; Varsha S Likhite; John A Katzenellenbogen; Benita S Katzenellenbogen
Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter.
The Journal of biological chemistry 2006;281(24):16272-8.
2006: Jai Woong Seo; John S Comninos; Dae Yoon Chi; Dong Wook Kim; Kathryn E Carlson; John A Katzenellenbogen
Fluorine-substituted cyclofenil derivatives as estrogen receptor ligands: synthesis and structure-affinity relationship study of potential positron emission tomography agents for imaging estrogen receptors in breast cancer.
Journal of medicinal chemistry 2006;49(8):2496-511.
2005: Meri De Angelis; Fabio Stossi; Michael Waibel; Benita S Katzenellenbogen; John A Katzenellenbogen
Isocoumarins as estrogen receptor beta selective ligands: Isomers of isoflavone phytoestrogens and their metabolites.
Bioorganic & medicinal chemistry 2005;13(23):6529-42.
2005: Hai-Bing Zhou; John S Comninos; Fabio Stossi; Benita S Katzenellenbogen; John A Katzenellenbogen
Synthesis and evaluation of estrogen receptor ligands with bridged oxabicyclic cores containing a diarylethylene motif: estrogen antagonists of unusual structure.
Journal of medicinal chemistry 2005;48(23):7261-74.
2005: Jeongsoo Yoo; Carmen S Dence; Terry L Sharp; John A Katzenellenbogen; Michael J Welch
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
Journal of medicinal chemistry 2005;48(20):6366-78.
2005: John A Katzenellenbogen
Designing effective hybrid toxins.
Chemistry & biology 2005;12(7):719-21.
2005: Anobel Tamrazi; Kathryn E Carlson; Alice L Rodriguez; John A Katzenellenbogen
Coactivator proteins as determinants of estrogen receptor structure and function: spectroscopic evidence for a novel coactivator-stabilized receptor conformation.
Molecular endocrinology (Baltimore, Md.) 2005;19(6):1516-28.
2005: Karuppiah Chockalingam; Zhilei Chen; John A Katzenellenbogen; Huimin Zhao
Directed evolution of specific receptor-ligand pairs for use in the creation of gene switches.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(16):5691-6.
2005: Heather M Bigott; Ephraim Parent; Leonard Luyt; John A Katzenellenbogen; Michael J Welch
Design and synthesis of functionalized cyclopentadienyl tricarbonylmetal complexes for technetium-94m PET imaging of estrogen receptors.
Bioconjugate chemistry 2005;16(2):255-64.
2005: Sung Hoon Kim; Anobel Tamrazi; Kathryn E Carlson; John A Katzenellenbogen
A proteomic microarray approach for exploring ligand-initiated nuclear hormone receptor pharmacology, receptor selectivity, and heterodimer functionality.
Molecular & cellular proteomics : MCP 2005;4(3):267-77.
2005: Meri De Angelis; Fabio Stossi; Kathryn A Carlson; Benita S Katzenellenbogen; John A Katzenellenbogen
Indazole estrogens: highly selective ligands for the estrogen receptor beta.
Journal of medicinal chemistry 2005;48(4):1132-44.
2004: Meri De Angelis; John A Katzenellenbogen
Ring nitrogen-substituted non-steroidal estrogens: pyridine and pyrimidine analogs of the phenol in deoxyhexestrol experience resonance constraints on preferred ligand conformation.
Bioorganic & medicinal chemistry letters 2004;14(23):5835-9.
2004: Dennis R Compton; Shubin Sheng; Kathryn E Carlson; Natalie A Rebacz; In Young Lee; Benita S Katzenellenbogen; John A Katzenellenbogen
Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity.
Journal of medicinal chemistry 2004;47(24):5872-93.
2004: Dennis R Compton; Kathryn E Carlson; John A Katzenellenbogen
Pyrazolo[1,5-a]pyrimidines as estrogen receptor ligands: defining the orientation of a novel heterocyclic core.
Bioorganic & medicinal chemistry letters 2004;14(22):5681-4.
2004: Vimal Selvaraj; Melissa A Zakroczymski; Afia Naaz; Motoko Mukai; Young H Ju; Daniel R Doerge; John A Katzenellenbogen; William G Helferich; Paul S Cooke
Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in mice.
Biology of reproduction 2004;71(3):966-72.
2004: Sung Hoon Kim; Anobel Tamrazi; Kathryn E Carlson; Jonathan R Daniels; In Young Lee; John A Katzenellenbogen
Estrogen receptor microarrays: subtype-selective ligand binding.
Journal of the American Chemical Society 2004;126(15):4754-5.
2004: Rajeev S Muthyala; Young H Ju; Shubin Sheng; Lee D Williams; Daniel R Doerge; Benita S Katzenellenbogen; William G Helferich; John A Katzenellenbogen
Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta.
Bioorganic & medicinal chemistry 2004;12(6):1559-67.
2004: Kyle M Hurth; Mark Joseph Nilges; Kathryn E Carlson; Anobel Tamrazi; R Linn Belford; John A Katzenellenbogen
Ligand-induced changes in estrogen receptor conformation as measured by site-directed spin labeling.
Biochemistry 2004;43(7):1891-907.
2004: Kendall W. Nettles; Jun Sun; James T Radek; Shubin Sheng; Alice L Rodriguez; John A Katzenellenbogen; Benita S Katzenellenbogen; Geoffrey L Greene
Allosteric control of ligand selectivity between estrogen receptors alpha and beta: implications for other nuclear receptors.
Molecular cell 2004;13(3):317-27.
2004: Alice L Rodriguez; Anobel Tamrazi; Margaret L Collins; John A Katzenellenbogen
Design, synthesis, and in vitro biological evaluation of small molecule inhibitors of estrogen receptor alpha coactivator binding.
Journal of medicinal chemistry 2004;47(3):600-11.
2003: Rajeev S Muthyala; Kathryn E Carlson; John A Katzenellenbogen
Exploration of the bicyclo[3.3.1]nonane system as a template for the development of new ligands for the estrogen receptor.
Bioorganic & medicinal chemistry letters 2003;13(24):4485-8.
2003: Anobel Tamrazi; Kathryn E Carlson; John A Katzenellenbogen
Molecular sensors of estrogen receptor conformations and dynamics.
Molecular endocrinology (Baltimore, Md.) 2003;17(12):2593-602.
2003: Leonard Luyt; Heather M Bigott; Michael J Welch; John A Katzenellenbogen
7alpha- and 17alpha-substituted estrogens containing tridentate tricarbonyl rhenium/technetium complexes: synthesis of estrogen receptor imaging agents and evaluation using microPET with technetium-94m.
Bioorganic & medicinal chemistry 2003;11(23):4977-89.
2003: William R Harrington; Shubin Sheng; Daniel Barnett; Larry N Petz; John A Katzenellenbogen; Benita S Katzenellenbogen
Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression.
Molecular and cellular endocrinology 2003;206(1-2):13-22.
2003: Kyo Chul Lee; Byung Seok Moon; Jae Hak Lee; Kyoo-Hyun Chung; John A Katzenellenbogen; Dae Yoon Chi
Synthesis and binding affinities of fluoroalkylated raloxifenes.
Bioorganic & medicinal chemistry 2003;11(17):3649-58.
2003: Dange Vijaykumar; Mohammed Al Qahtani; Michael J Welch; John A Katzenellenbogen
Synthesis and biological evaluation of a fluorine-18 labeled estrogen receptor-alpha selective ligand: [18F] propyl pyrazole triol.
Nuclear medicine and biology 2003;30(4):397-404.
2003: Rajeev S Muthyala; Shubin Sheng; Kathryn E Carlson; Benita S Katzenellenbogen; John A Katzenellenbogen
Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor.
Journal of medicinal chemistry 2003;46(9):1589-602.
2003: Usha Ghosh; Deshanie Ganessunker; Viswajanani J Sattigeri; Kathryn E Carlson; Deborah J Mortensen; Benita S Katzenellenbogen; John A Katzenellenbogen
Estrogenic diazenes: heterocyclic non-steroidal estrogens of unusual structure with selectivity for estrogen receptor subtypes.
Bioorganic & medicinal chemistry 2003;11(4):629-57.
2003: Frank Wüst; Kathryn E Carlson; John A Katzenellenbogen
Synthesis of novel arylpyrazolo corticosteroids as potential ligands for imaging brain glucocorticoid receptors.
Steroids 2003;68(2):177-91.
2003: Jun Sun; Jerome Baudry; John A Katzenellenbogen; Benita S Katzenellenbogen
Molecular basis for the subtype discrimination of the estrogen receptor-beta-selective ligand, diarylpropionitrile.
Molecular endocrinology (Baltimore, Md.) 2003;17(2):247-58.
2003: Anobel Tamrazi; John A Katzenellenbogen
Site-specific fluorescent labeling of estrogen receptors and structure-activity relationships of ligands in terms of receptor dimer stability.
Methods in enzymology 2003;364():37-53.
2002: Anobel Tamrazi; Kathryn E Carlson; Jonathan R Daniels; Kyle M Hurth; John A Katzenellenbogen
Estrogen receptor dimerization: ligand binding regulates dimer affinity and dimer dissociation rate.
Molecular endocrinology (Baltimore, Md.) 2002;16(12):2706-19.
2002: Leonard Luyt; John A Katzenellenbogen
A trithiolate tripodal bifunctional ligand for the radiolabeling of peptides with gallium(III).
Bioconjugate chemistry 2002;13(5):1140-5.
2002: Dange Vijaykumar; Wang Mao; Karen S Kirschbaum; John A Katzenellenbogen
An efficient route for the preparation of a 21-fluoro progestin-16 alpha,17 alpha-dioxolane, a high-affinity ligand for PET imaging of the progesterone receptor.
The Journal of organic chemistry 2002;67(14):4904-10.
2002: Andrew K Shiau; Danielle Barstad; James T Radek; Marvin J Meyers; Kendall W. Nettles; Benita S Katzenellenbogen; John A Katzenellenbogen; David A Agard; Geoffrey L Greene
Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.
Nature structural biology 2002;9(5):359-64.
2002: Eric S Mull; Viswajanani J Sattigeri; Alice L Rodriguez; John A Katzenellenbogen
Aryl cyclopentadienyl tricarbonyl rhenium complexes: novel ligands for the estrogen receptor with potential use as estrogen radiopharmaceuticals.
Bioorganic & medicinal chemistry 2002;10(5):1381-98.
2002: Benita S Katzenellenbogen; John A Katzenellenbogen
Biomedicine. Defining the "S" in SERMs.
Science (New York, N.Y.) 2002;295(5564):2380-1.
2002: Gisele A Nishiguchi; Alice L Rodriguez; John A Katzenellenbogen
Diaryl-dialkyl-substituted pyrazoles: regioselective synthesis and binding affinity for the estrogen receptor.
Bioorganic & medicinal chemistry letters 2002;12(6):947-50.
2002: Jun Sun; Ying R Huang; William R Harrington; Shubin Sheng; John A Katzenellenbogen; Benita S Katzenellenbogen
Antagonists selective for estrogen receptor alpha.
Endocrinology 2002;143(3):941-7.
2002: Richard R Cesati; Gilles Tamagnan; Ronald M Baldwin; Sami S Zoghbi; Robert B Innis; Nora S Kula; Ross J Baldessarini; John A Katzenellenbogen
Synthesis of cyclopentadienyltricarbonyl rhenium phenyltropanes by double ligand transfer: organometallic ligands for the dopamine transporter.
Bioconjugate chemistry 2002;13(1):29-39.
2001: Benita S Katzenellenbogen; Jun Sun; William R Harrington; DM Kraichely; Deshanie Ganessunker; John A Katzenellenbogen
Structure-function relationships in estrogen receptors and the characterization of novel selective estrogen receptor modulators with unique pharmacological profiles.
Annals of the New York Academy of Sciences 2001;949():6-15.
2001: Marvin J Meyers; Jun Sun; Kathryn E Carlson; G A Marriner; Benita S Katzenellenbogen; John A Katzenellenbogen
Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues.
Journal of medicinal chemistry 2001;44(24):4230-51.
2001: DS Mortensen; Alice L Rodriguez; Kathryn E Carlson; Jun Sun; Benita S Katzenellenbogen; John A Katzenellenbogen
Synthesis and biological evaluation of a novel series of furans: ligands selective for estrogen receptor alpha.
Journal of medicinal chemistry 2001;44(23):3838-48.
2001: DS Mortensen; Alice L Rodriguez; Jun Sun; Benita S Katzenellenbogen; John A Katzenellenbogen
Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha.
Bioorganic & medicinal chemistry letters 2001;11(18):2521-4.
2001: R Tedesco; M K Youngman; S R Wilson; John A Katzenellenbogen
Synthesis and evaluation of hexahydrochrysene and tetrahydrobenzofluorene ligands for the estrogen receptor.
Bioorganic & medicinal chemistry letters 2001;11(10):1281-4.
2001: S H Kim; SD Jonson; Michael J Welch; John A Katzenellenbogen
Fluorine-substituted ligands for the peroxisome proliferator-activated receptor gamma (PPARgamma): potential imaging agents for metastatic tumors.
Bioconjugate chemistry 2001;12(3):439-50.
2001: R Tedesco; J A Thomas; Benita S Katzenellenbogen; John A Katzenellenbogen
The estrogen receptor: a structure-based approach to the design of new specific hormone-receptor combinations.
Chemistry & biology 2001;8(3):277-87.
2001: SR Stauffer; Y R Huang; Zachary D Aron; CJ Coletta; Jun Sun; Benita S Katzenellenbogen; John A Katzenellenbogen
Triarylpyrazoles with basic side chains: development of pyrazole-based estrogen receptor antagonists.
Bioorganic & medicinal chemistry 2001;9(1):151-61.
2001: SR Stauffer; Y Huang; CJ Coletta; R Tedesco; John A Katzenellenbogen
Estrogen pyrazoles: defining the pyrazole core structure and the orientation of substituents in the ligand binding pocket of the estrogen receptor.
Bioorganic & medicinal chemistry 2001;9(1):141-50.
2000: SR Stauffer; CJ Coletta; R Tedesco; G Nishiguchi; K Carlson; Jun Sun; Benita S Katzenellenbogen; John A Katzenellenbogen
Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists.
Journal of medicinal chemistry 2000;43(26):4934-47.
2000: Benita S Katzenellenbogen; I Choi; R Delage-Mourroux; Tracy R Ediger; Paolo G V Martini; MM Montano; Jun Sun; KE Weis; John A Katzenellenbogen
Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology.
The Journal of steroid biochemistry and molecular biology 2000;74(5):279-85.
2000: Richard R Cesati; John A Katzenellenbogen
Preparation of hexahydrobenzo[f]isoquinolines using a vinylogous pictet-spengler cyclization.
Organic letters 2000;2(23):3635-8.
2000: Young H Ju; K E Carlson; J Sun; Dorothy R Pathak; Benita S Katzenellenbogen; John A Katzenellenbogen; William G Helferich
Estrogenic effects of extracts from cabbage, fermented cabbage, and acidified brussels sprouts on growth and gene expression of estrogen-dependent human breast cancer (MCF-7) cells.
Journal of agricultural and food chemistry 2000;48(10):4628-34.
2000: DM Kraichely; Jun Sun; John A Katzenellenbogen; Benita S Katzenellenbogen
Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: correlations with biological character and distinct differences among SRC coactivator family members.
Endocrinology 2000;141(10):3534-45.
2000: Y R Huang; John A Katzenellenbogen
Regioselective synthesis of 1,3,5-triaryl-4-alkylpyrazoles: novel ligands for the estrogen receptor.
Organic letters 2000;2(18):2833-6.
2000: SR Stauffer; John A Katzenellenbogen
Solid-phase synthesis of tetrasubstituted pyrazoles, novel ligands for the estrogen receptor.
Journal of combinatorial chemistry 2000;2(4):318-29.
2000: SR Stauffer; Jun Sun; Benita S Katzenellenbogen; John A Katzenellenbogen
Acyclic amides as estrogen receptor ligands: synthesis, binding, activity and receptor interaction.
Bioorganic & medicinal chemistry 2000;8(6):1293-316.
2000: MB Skaddan; Frank Wüst; SD Jonson; Rosemarie Syhre; Michael J Welch; Hartmut Spies; John A Katzenellenbogen
Radiochemical synthesis and tissue distribution of Tc-99m-labeled 7alpha-substituted estradiol complexes.
Nuclear medicine and biology 2000;27(3):269-78.
2000: S H Kim; John A Katzenellenbogen
Triarylethylene bisphenols with a novel cycle are ligands for the estrogen receptor.
Bioorganic & medicinal chemistry 2000;8(4):785-93.
2000: Benita S Katzenellenbogen; John A Katzenellenbogen
Estrogen receptor transcription and transactivation: Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer.
Breast cancer research : BCR 2000;2(5):335-44.
2000: Benita S Katzenellenbogen; MM Montano; Tracy R Ediger; Jun Sun; K Ekena; G Lazennec; Paolo G V Martini; EM McInerney; R Delage-Mourroux; KE Weis; John A Katzenellenbogen
Estrogen receptors: selective ligands, partners, and distinctive pharmacology.
Recent progress in hormone research 2000;55():163-93; discussion 194-5.
1999: Arvin Gee; Kathryn E Carlson; P G Martini; Benita S Katzenellenbogen; John A Katzenellenbogen
Coactivator peptides have a differential stabilizing effect on the binding of estrogens and antiestrogens with the estrogen receptor.
Molecular endocrinology (Baltimore, Md.) 1999;13(11):1912-23.
1999: Frank Wüst; MB Skaddan; Peter Leibnitz; Hartmut Spies; John A Katzenellenbogen; Bernd Johannsen
Synthesis of novel progestin-rhenium conjugates as potential ligands for the progesterone receptor.
Bioorganic & medicinal chemistry 1999;7(9):1827-35.
1999: Marvin J Meyers; Jun Sun; Kathryn E Carlson; Benita S Katzenellenbogen; John A Katzenellenbogen
Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11, 12-tetrahydrochrysenes.
Journal of medicinal chemistry 1999;42(13):2456-68.
1999: B E Fink; DS Mortensen; SR Stauffer; Zachary D Aron; John A Katzenellenbogen
Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens.
Chemistry & biology 1999;6(4):205-19.
1999: Jun Sun; Marvin J Meyers; B E Fink; R Rajendran; John A Katzenellenbogen; Benita S Katzenellenbogen
Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta.
Endocrinology 1999;140(2):800-4.
1999: SD Jonson; T A Bonasera; Farrokh Dehdashti; ME Cristel; John A Katzenellenbogen; Michael J Welch
Comparative breast tumor imaging and comparative in vitro metabolism of 16alpha-[18F]fluoroestradiol-17beta and 16beta-[18F]fluoromoxestrol in isolated hepatocytes.
Nuclear medicine and biology 1999;26(1):123-30.
1999: TW Spradau; WB Edwards; Carolyn J Anderson; Michael J Welch; John A Katzenellenbogen
Synthesis and biological evaluation of Tc-99m-cyclopentadienyltricarbonyltechnetium-labeled octreotide.
Nuclear medicine and biology 1999;26(1):1-7.
1999: MB Skaddan; John A Katzenellenbogen
Integrated "3+1" oxorhenium(V) complexes as estrogen mimics.
Bioconjugate chemistry 1999;10(1):119-29.
1998: Marvin J Meyers; Kathryn E Carlson; John A Katzenellenbogen
Facile synthesis of high affinity styrylpyridine systems as inherently fluorescent ligands for the estrogen receptor.
Bioorganic & medicinal chemistry letters 1998;8(24):3589-94.
1998: Frank Wüst; K E Carlson; John A Katzenellenbogen; Hartmut Spies; Bernd Johannsen
Synthesis and binding affinities of new 17 alpha-substituted estradiol-rhenium "n + 1" mixed-ligand and thioether-carbonyl complexes.
Steroids 1998;63(12):665-71.
1998: TW Spradau; John A Katzenellenbogen
Ligands for the estrogen receptor, containing cyclopentadienyltricarbonylrhenium units.
Bioorganic & medicinal chemistry letters 1998;8(22):3235-40.
1998: TW Spradau; John A Katzenellenbogen
Protein and peptide labeling with (cyclopentadienyl)tricarbonyl rhenium and technetium.
Bioconjugate chemistry 1998;9(6):765-72.
1998: SD Jonson; D A d'Avignon; John A Katzenellenbogen; Michael J Welch
Methyl hypofluorite in the synthesis of 16-methoxyestradiol stereoisomers.
Steroids 1998;63(9):470-8.
1998: K Ekena; John A Katzenellenbogen; Benita S Katzenellenbogen
Determinants of ligand specificity of estrogen receptor-alpha: estrogen versus androgen discrimination.
The Journal of biological chemistry 1998;273(2):693-9.
1997: Kathryn E Carlson; I Choi; Arvin Gee; Benita S Katzenellenbogen; John A Katzenellenbogen
Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: evidence that an open pocket conformation is required for ligand interaction.
Biochemistry 1997;36(48):14897-905.
1997: R K Hom; John A Katzenellenbogen
Technetium-99m-labeled receptor-specific small-molecule radiopharmaceuticals: recent developments and encouraging results.
Nuclear medicine and biology 1997;24(6):485-98.
1997: John A Katzenellenbogen; Michael J Welch; F Dehdashti
The development of estrogen and progestin radiopharmaceuticals for imaging breast cancer.
Anticancer research 1997;17(3B):1573-6.
1997: T A Bonasera; SD Jonson; T S Pajeau; John A Katzenellenbogen; Michael J Welch
Retardation of 17-oxidation of 16 alpha-[18F]fluoroestradiol-17 beta by substitution of deuterium for hydrogen in the 17 alpha position(6).
Nuclear medicine and biology 1997;24(3):239-49.
1997: A W Scribner; SD Jonson; Michael J Welch; John A Katzenellenbogen
Synthesis, estrogen receptor binding, and tissue distribution of [18F]fluorodoisynolic acids.
Nuclear medicine and biology 1997;24(3):209-24.
1997: K Ekena; KE Weis; John A Katzenellenbogen; Benita S Katzenellenbogen
Different residues of the human estrogen receptor are involved in the recognition of structurally diverse estrogens and antiestrogens.
The Journal of biological chemistry 1997;272(8):5069-75.
1996: P R Kym; K L Hummert; A G Nilsson; M Lubin; John A Katzenellenbogen
Bisphenolic compounds that enhance cell cation transport are found in commercial phenol red.
Journal of medicinal chemistry 1996;39(25):4897-904.
1996: K Ekena; K E Weis; John A Katzenellenbogen; Benita S Katzenellenbogen
Identification of amino acids in the hormone binding domain of the human estrogen receptor important in estrogen binding.
The Journal of biological chemistry 1996;271(33):20053-9.
1996: J E Mortimer; Farrokh Dehdashti; Barry A Siegel; John A Katzenellenbogen; P Fracasso; Michael J Welch
Positron emission tomography with 2-[18F]Fluoro-2-deoxy-D-glucose and 16alpha-[18F]fluoro-17beta-estradiol in breast cancer: correlation with estrogen receptor status and response to systemic therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(6):933-9.
1996: T A Bonasera; James P O'Neil; M Xu; J A Dobkin; PD Cutler; L L Lich; Y S Choe; John A Katzenellenbogen; Michael J Welch
Preclinical evaluation of fluorine-18-labeled androgen receptor ligands in baboons.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1996;37(6):1009-15.
1996: Carmen S Dence; E Napolitano; John A Katzenellenbogen; Michael J Welch
Carbon-11-labeled estrogens as potential imaging agents for breast tumors.
Nuclear medicine and biology 1996;23(4):491-6.
1996: John A Katzenellenbogen; Bert W O'Malley; Benita S Katzenellenbogen
Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones.
Molecular endocrinology (Baltimore, Md.) 1996;10(2):119-31.
1995: D A Seielstad; Kathryn E Carlson; P J Kushner; G L Greene; John A Katzenellenbogen
Analysis of the structural core of the human estrogen receptor ligand binding domain by selective proteolysis/mass spectrometric analysis.
Biochemistry 1995;34(39):12605-15.
1995: Farrokh Dehdashti; J E Mortimer; Barry A Siegel; L K Griffeth; T J Bonasera; M J Fusselman; D D Detert; PD Cutler; John A Katzenellenbogen; Michael J Welch
Positron tomographic assessment of estrogen receptors in breast cancer: comparison with FDG-PET and in vitro receptor assays.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(10):1766-74.
1995: John A Katzenellenbogen; R E Coleman; R A Hawkins; K A Krohn; Steven M Larson; J Mendelsohn; C Kent Osborne; D Piwnica-Worms; R C Reba; B A Siegel
Tumor receptor imaging: proceedings of the National Cancer Institute workshop, review of current work, and prospective for further investigations.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(8):921-32.
1995: Elio Napolitano; Rita Fiaschi; K E Carlson; John A Katzenellenbogen
11 beta-substituted estradiol derivatives. 2. Potential carbon-11- and iodine-labeled probes for the estrogen receptor.
Journal of medicinal chemistry 1995;38(14):2774-9.
1995: Y S Choe; T A Bonasera; Dae Yoon Chi; Michael J Welch; John A Katzenellenbogen
6 alpha-[18F]fluoroprogesterone: synthesis via halofluorination-oxidation, receptor binding and tissue distribution.
Nuclear medicine and biology 1995;22(5):635-42.
1995: D A Seielstad; Kathryn E Carlson; John A Katzenellenbogen; P J Kushner; G L Greene
Molecular characterization by mass spectrometry of the human estrogen receptor ligand-binding domain expressed in Escherichia coli.
Molecular endocrinology (Baltimore, Md.) 1995;9(6):647-58.
1995: John A Katzenellenbogen
Designing steroid receptor-based radiotracers to image breast and prostate tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(6 Suppl):8S-13S.
1995: Y S Choe; John A Katzenellenbogen
Synthesis of C-6 fluoroandrogens: evaluation of ligands for tumor receptor imaging.
Steroids 1995;60(5):414-22.
1995: R J Miksicek; Kathryn E Carlson; K J Hwang; John A Katzenellenbogen
Studies using fluorescent tetrahydrochrysene estrogens for in situ visualization of the estrogen receptor in living cells.
Molecular endocrinology (Baltimore, Md.) 1995;9(5):592-604.
1995: Y S Choe; P J Lidström; Dae Yoon Chi; T A Bonasera; Michael J Welch; John A Katzenellenbogen
Synthesis of 11 beta-[18F]fluoro-5 alpha-dihydrotestosterone and 11 beta-[18F]fluoro-19-nor-5 alpha-dihydrotestosterone: preparation via halofluorination-reduction, receptor binding, and tissue distribution.
Journal of medicinal chemistry 1995;38(5):816-25.
1995: Dae Yoon Chi; S R Wilson; John A Katzenellenbogen
Crystal structure of doisynolic acid and the structure of other products formed during its synthesis.
Steroids 1995;60(3):261-4.
1995: Elio Napolitano; Rita Fiaschi; K E Carlson; John A Katzenellenbogen
11 beta-Substituted estradiol derivatives, potential high-affinity carbon-11-labeled probes for the estrogen receptor: a structure-affinity relationship study.
Journal of medicinal chemistry 1995;38(3):429-34.
1995: Brad Buckman; T A Bonasera; K S Kirschbaum; Michael J Welch; John A Katzenellenbogen
Fluorine-18-labeled progestin 16 alpha, 17 alpha-dioxolanes: development of high-affinity ligands for the progesterone receptor with high in vivo target site selectivity.
Journal of medicinal chemistry 1995;38(2):328-37.
1995: P R Kym; Kathryn E Carlson; John A Katzenellenbogen
Evaluation of a highly efficient aryl azide photoaffinity labeling reagent for the progesterone receptor.
Bioconjugate chemistry 1995;6(1):115-22.
1994: Brad Buckman; Henry VanBrocklin; C S Dence; Steven Bergmann; Michael J Welch; John A Katzenellenbogen
Synthesis and tissue biodistribution of [omega-11C]palmitic acid. A novel PET imaging agent for cardiac fatty acid metabolism.
Journal of medicinal chemistry 1994;37(15):2481-5.
1994: K E Bergmann; C H Wooge; Kathryn E Carlson; Benita S Katzenellenbogen; John A Katzenellenbogen
Bivalent ligands as probes of estrogen receptor action.
The Journal of steroid biochemistry and molecular biology 1994;49(2-3):139-52.
1994: James P O'Neil; Kathryn E Carlson; Carolyn J Anderson; Michael J Welch; John A Katzenellenbogen
Progestin radiopharmaceuticals labeled with technetium and rhenium: synthesis, binding affinity, and in vivo distribution of a new progestin N2S2-metal conjugate.
Bioconjugate chemistry 1994;5(3):182-93.
1994: Dae Yoon Chi; James P O'Neil; Carolyn J Anderson; Michael J Welch; John A Katzenellenbogen
Homodimeric and heterodimeric bis(amino thiol) oxometal complexes with rhenium(V) and technetium(V). Control of heterodimeric complex formation and an approach to metal complexes that mimic steroid hormones.
Journal of medicinal chemistry 1994;37(7):928-37.
1994: K E Bergmann; Kathryn E Carlson; John A Katzenellenbogen
Hexestrol diazirine photoaffinity labeling reagent for the estrogen receptor.
Bioconjugate chemistry 1994;5(2):141-50.
1994: K E Bergmann; S W Landvatter; P G Rocque; Kathryn E Carlson; Michael J Welch; John A Katzenellenbogen
Oxohexestrol derivatives labeled with fluorine-18. Synthesis, receptor binding and in vivo distribution of two non-steroidal estrogens as potential breast tumor imaging agents.
Nuclear medicine and biology 1994;21(1):25-39.
1994: Henry VanBrocklin; A Liu; Michael J Welch; James P O'Neil; John A Katzenellenbogen
The synthesis of 7 alpha-methyl-substituted estrogens labeled with fluorine-18: potential breast tumor imaging agents.
Steroids 1994;59(1):34-45.
1993: Gregory M Anstead; Kathryn E Carlson; P R Kym; K J Hwang; John A Katzenellenbogen
The effect of acceptor group variation on the solvatochromism of donor-acceptor fluorophores.
Photochemistry and photobiology 1993;58(6):785-94.
1993: P R Kym; Gregory M Anstead; K G Pinney; S R Wilson; John A Katzenellenbogen
Molecular structures, conformational analysis, and preferential modes of binding of 3-aroyl-2-arylbenzo[b]thiophene estrogen receptor ligands: LY117018 and aryl azide photoaffinity labeling analogs.
Journal of medicinal chemistry 1993;36(24):3910-22.
1993: John A Katzenellenbogen; C J Mathias; Henry VanBrocklin; J W Brodack; Michael J Welch
Titration of the in vivo uptake of 16 alpha-[18F]fluoroestradiol by target tissues in the rat: competition by tamoxifen, and implications for quantitating estrogen receptors in vivo and the use of animal models in receptor-binding radiopharmaceutical development.
Nuclear medicine and biology 1993;20(6):735-45.
1993: Henry VanBrocklin; Kathryn E Carlson; John A Katzenellenbogen; Michael J Welch
16 beta-([18F]fluoro)estrogens: systematic investigation of a new series of fluorine-18-labeled estrogens as potential imaging agents for estrogen-receptor-positive breast tumors.
Journal of medicinal chemistry 1993;36(11):1619-29.
1993: M J Kochanny; Henry VanBrocklin; P R Kym; Kathryn E Carlson; James P O'Neil; T A Bonasera; Michael J Welch; John A Katzenellenbogen
Fluorine-18-labeled progestin ketals: synthesis and target tissue uptake selectivity of potential imaging agents for receptor-positive breast tumors.
Journal of medicinal chemistry 1993;36(9):1120-7.
1993: P R Kym; Kathryn E Carlson; John A Katzenellenbogen
Progestin 16 alpha, 17 alpha-dioxolane ketals as molecular probes for the progesterone receptor: synthesis, binding affinity, and photochemical evaluation.
Journal of medicinal chemistry 1993;36(9):1111-9.
1993: Gregory M Anstead; K J Hwang; John A Katzenellenbogen
Characterization of the spectroscopic properties of a tetrahydrochrysene system containing a rigidified hydroxynitrostilbene chromophore: an inherently fluorescent ligand designed for the estrogen receptor.
Photochemistry and photobiology 1993;57(4):616-28.
1993: A N French; S R Wilson; Michael J Welch; John A Katzenellenbogen
A synthesis of 7 alpha-substituted estradiols: synthesis and biological evaluation of a 7 alpha-pentyl-substituted BODIPY fluorescent conjugate and a fluorine-18-labeled 7 alpha-pentylestradiol analog.
Steroids 1993;58(4):157-69.
1993: A N French; Elio Napolitano; Henry VanBrocklin; Robert N Hanson; Michael J Welch; John A Katzenellenbogen
Synthesis, radiolabeling and tissue distribution of 11 beta-fluoroalkyl- and 11 beta-fluoroalkoxy-substituted estrogens: target tissue uptake selectivity and defluorination of a homologous series of fluorine-18-labeled estrogens.
Nuclear medicine and biology 1993;20(1):31-47.
1993: Henry VanBrocklin; P A Rocque; H V Lee; Kathryn E Carlson; John A Katzenellenbogen; Michael J Welch
16 beta-[18F]fluoromoxestrol: a potent, metabolically stable positron emission tomography imaging agent for estrogen receptor positive human breast tumors.
Life sciences 1993;53(10):811-9.
1992: K J Hwang; Kathryn E Carlson; Gregory M Anstead; John A Katzenellenbogen
Donor-acceptor tetrahydrochrysenes, inherently fluorescent, high-affinity ligands for the estrogen receptor: binding and fluorescence characteristics and fluorometric assay of receptor.
Biochemistry 1992;31(46):11536-45.
1992: R Rai; John A Katzenellenbogen
Effect of conformational mobility and hydrogen-bonding interactions on the selectivity of some guanidinoaryl-substituted mechanism-based inhibitors of trypsin-like serine proteases.
Journal of medicinal chemistry 1992;35(23):4297-305.
1992: R Rai; John A Katzenellenbogen
Guanidinophenyl-substituted enol lactones as selective, mechanism-based inhibitors of trypsin-like serine proteases.
Journal of medicinal chemistry 1992;35(22):4150-9.
1992: A Liu; Kathryn E Carlson; John A Katzenellenbogen
Synthesis of high affinity fluorine-substituted ligands for the androgen receptor. Potential agents for imaging prostatic cancer by positron emission tomography.
Journal of medicinal chemistry 1992;35(11):2113-29.
1992: J P DiZio; Kathryn E Carlson; C J Bannochie; Michael J Welch; E Von Angerer; John A Katzenellenbogen
Estrogen platinum-diamine complexes: preparation of a non-steroidal estrogen platinum-diamine complex labeled with platinum-191 and a study of its binding to the estrogen receptor in vitro and its tissue distribution in vivo.
The Journal of steroid biochemistry and molecular biology 1992;42(3-4):363-73.
1992: A Liu; C S Dence; Michael J Welch; John A Katzenellenbogen
Fluorine-18-labeled androgens: radiochemical synthesis and tissue distribution studies on six fluorine-substituted androgens, potential imaging agents for prostatic cancer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992;33(5):724-34.
1992: Martin G Pomper; M J Kochanny; A M Thieme; Kathryn E Carlson; Henry VanBrocklin; C J Mathias; Michael J Welch; John A Katzenellenbogen
Fluorine-substituted corticosteroids: synthesis and evaluation as potential receptor-based imaging agents for positron emission tomography of the brain.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1992;19(4):461-80.
1992: K G Pinney; Kathryn E Carlson; John A Katzenellenbogen
Nonsteroidal estrogens bearing acyl azide functions: potential electrophilic and photoaffinity labeling agents for the estrogen receptor.
Steroids 1992;57(5):222-32.
1992: Henry VanBrocklin; Martin G Pomper; Kathryn E Carlson; Michael J Welch; John A Katzenellenbogen
Preparation and evaluation of 17-ethynyl-substituted 16 alpha-[18F]fluoroestradiols: selective receptor-based PET imaging agents.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1992;19(3):363-74.
1992: J P DiZio; Carolyn J Anderson; A Davison; G J Ehrhardt; Kathryn E Carlson; Michael J Welch; John A Katzenellenbogen
Technetium- and rhenium-labeled progestins: synthesis, receptor binding and in vivo distribution of an 11 beta-substituted progestin labeled with technetium-99 and rhenium-186.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992;33(4):558-69.
1991: J P DiZio; R Fiaschi; A Davison; A G Jones; John A Katzenellenbogen
Progestin-rhenium complexes: metal-labeled steroids with high receptor binding affinity, potential receptor-directed agents for diagnostic imaging or therapy.
Bioconjugate chemistry 1991;2(5):353-66.
1991: D J Baek; John A Katzenellenbogen
Halo enol lactone inhibitors of chymotrypsin: burst kinetics and enantioselectivity of inactivation.
Biochemical and biophysical research communications 1991;178(3):1335-42.
1991: Farrokh Dehdashti; A H McGuire; H F Van Brocklin; Barry A Siegel; D P Andriole; L K Griffeth; Martin G Pomper; John A Katzenellenbogen; Michael J Welch
Assessment of 21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone as a positron-emitting radiopharmaceutical for the detection of progestin receptors in human breast carcinomas.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1991;32(8):1532-7.
1991: A H McGuire; Farrokh Dehdashti; Barry A Siegel; A P Lyss; J W Brodack; C J Mathias; M A Mintun; John A Katzenellenbogen; Michael J Welch
Positron tomographic assessment of 16 alpha-[18F] fluoro-17 beta-estradiol uptake in metastatic breast carcinoma.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1991;32(8):1526-31.
1991: K G Pinney; Kathryn E Carlson; Benita S Katzenellenbogen; John A Katzenellenbogen
Efficient and selective photoaffinity labeling of the estrogen receptor using two nonsteroidal ligands that embody aryl azide or tetrafluoroaryl azide photoreactive functions.
Biochemistry 1991;30(9):2421-31.
1991: P E Reed; John A Katzenellenbogen
Beta-substituted beta-phenylpropionyl chymotrypsins. Structural and stereochemical features in stable acyl enzymes.
Journal of medicinal chemistry 1991;34(3):1162-76.
1991: P E Reed; John A Katzenellenbogen
Proline-valine pseudo peptide enol lactones. Effective and selective inhibitors of chymotrypsin and human leukocyte elastase.
The Journal of biological chemistry 1991;266(1):13-21.
1991: A J Liu; John A Katzenellenbogen; Henry VanBrocklin; C J Mathias; Michael J Welch
20-[18F]fluoromibolerone, a positron-emitting radiotracer for androgen receptors: synthesis and tissue distribution studies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1991;32(1):81-8.
1990: Martin G Pomper; Henry VanBrocklin; A M Thieme; R D Thomas; D O Kiesewetter; Kathryn E Carlson; C J Mathias; Michael J Welch; John A Katzenellenbogen
11 beta-methoxy-, 11 beta-ethyl- and 17 alpha-ethynyl-substituted 16 alpha-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity.
Journal of medicinal chemistry 1990;33(12):3143-55.
1990: Gregory M Anstead; C S Peterson; K G Pinney; S R Wilson; John A Katzenellenbogen
Torsionally and hydrophobically modified 2,3-diarylindenes as estrogen receptor ligands.
Journal of medicinal chemistry 1990;33(10):2726-34.
1990: Kathryn E Carlson; John A Katzenellenbogen
A comparative study of the selectivity and efficiency of target tissue uptake of five tritium-labeled androgens in the rat.
Journal of steroid biochemistry 1990;36(6):549-61.
1990: S S Pochapsky; Henry VanBrocklin; Michael J Welch; John A Katzenellenbogen
Synthesis and tissue distribution of fluorine-18 labeled trifluorohexadecanoic acids. Considerations in the development of metabolically blocked myocardial imaging agents.
Bioconjugate chemistry 1990;1(4):231-44.
1990: D J Baek; P E Reed; S B Daniels; John A Katzenellenbogen
Alternate substrate inhibitors of an alpha-chymotrypsin: enantioselective interaction of aryl-substituted enol lactones.
Biochemistry 1990;29(18):4305-11.
1990: K G Pinney; Kathryn E Carlson; John A Katzenellenbogen
[3H]DU41165: a high affinity ligand and novel photoaffinity labeling reagent for the progesterone receptor.
Journal of steroid biochemistry 1990;35(2):179-89.
1990: Martin G Pomper; K G Pinney; Kathryn E Carlson; H van Brocklin; C J Mathias; Michael J Welch; John A Katzenellenbogen
Target tissue uptake selectivity of three fluorine-substituted progestins: potential imaging agents for receptor-positive breast tumors.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1990;17(3):309-19.
1990: Henry VanBrocklin; J W Brodack; C J Mathias; Michael J Welch; John A Katzenellenbogen; J F Keenan; G J Mizejewski
Binding of 16 alpha-[18F]fluoro-17 beta-estradiol to alphafetoprotein in Sprague-Dawley female rats affects blood levels.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1990;17(8):769-73.
1989: Gregory M Anstead; C S Peterson; John A Katzenellenbogen
Hydroxylated 2,3-diarylindenes: synthesis, estrogen receptor binding affinity, and binding orientation considerations.
Journal of steroid biochemistry 1989;33(5):877-87.
1989: Gregory M Anstead; S R Wilson; John A Katzenellenbogen
2-Arylindenes and 2-arylindenones: molecular structures and considerations in the binding orientation of unsymmetrical nonsteroidal ligands to the estrogen receptor.
Journal of medicinal chemistry 1989;32(9):2163-71.
1989: Kathryn E Carlson; M Coppey; H Magdelenat; John A Katzenellenbogen
Receptor binding of NBD-labeled fluorescent estrogens and progestins in whole cells and cell-free preparations.
Journal of steroid biochemistry 1989;32(3):345-55.
1988: M A Mintun; Michael J Welch; Barry A Siegel; C J Mathias; J W Brodack; A H McGuire; John A Katzenellenbogen
Breast cancer: PET imaging of estrogen receptors.
Radiology 1988;169(1):45-8.
1988: R D Bindal; John A Katzenellenbogen
Bis(4-hydroxyphenyl)[2-(phenoxysulfonyl)phenyl]methane: isolation and structure elucidation of a novel estrogen from commercial preparations of phenol red (phenolsulfonphthalein)
Journal of medicinal chemistry 1988;31(10):1978-83.
1988: R D Bindal; Kathryn E Carlson; Benita S Katzenellenbogen; John A Katzenellenbogen
Lipophilic impurities, not phenolsulfonphthalein, account for the estrogenic activity in commercial preparations of phenol red.
Journal of steroid biochemistry 1988;31(3):287-93.
1988: Gregory M Anstead; John A Katzenellenbogen
Optimizing of 2,3-diarylindenes as fluorescent estrogens: variation of the acceptor group, ortho substitution of the 2-ring, and C-1 methylation.
Journal of medicinal chemistry 1988;31(9):1754-61.
1988: Gregory M Anstead; R J Altenbach; S R Wilson; John A Katzenellenbogen
2,3-Diarylindenes and 2,3-diarylindenones: synthesis, molecular structure, photochemistry, estrogen receptor binding affinity, and comparisons with related triarylethylenes.
Journal of medicinal chemistry 1988;31(7):1316-26.
1988: Martin G Pomper; John A Katzenellenbogen; Michael J Welch; J W Brodack; C J Mathias
21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone: synthesis and target tissue selective uptake of a progestin receptor based radiotracer for positron emission tomography.
Journal of medicinal chemistry 1988;31(7):1360-3.
1988: T L Fevig; M K Mao; John A Katzenellenbogen
Estrogen receptor binding tolerance of 16 alpha-substituted estradiol derivatives.
Steroids 1988;51(5-6):471-97.
1988: S J Brandes; John A Katzenellenbogen
Fundamental considerations in the design of fluorine-18 labeled progestins and androgens as imaging agents for receptor-positive tumors of the breast and prostate.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1988;15(1):53-67.
1988: Michael J Welch; John A Katzenellenbogen; C J Mathias; J W Brodack; Kathryn E Carlson; Dae Yoon Chi; Carmen S Dence; Michael R Kilbourn; J S Perlmutter; M E Raichle
N-(3-[18F]fluoropropyl)-spiperone: the preferred 18F labeled spiperone analog for positron emission tomographic studies of the dopamine receptor.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1988;15(1):83-97.
1988: Kathryn E Carlson; S J Brandes; Martin G Pomper; John A Katzenellenbogen
Uptake of three [3H]progestins by target tissues in vivo: implications for the design of diagnostic imaging agents.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1988;15(4):403-8.
1987: R D Bindal; Kathryn E Carlson; G C Reiner; John A Katzenellenbogen
11 beta-chloromethyl-[3H]estradiol-17 beta: a very high affinity, reversible ligand for the estrogen receptor.
Journal of steroid biochemistry 1987;28(4):361-70.
1987: D M Simpson; J F Elliston; John A Katzenellenbogen
Desmethylnafoxidine aziridine: an electrophilic affinity label for the estrogen receptor with high efficiency and selectivity.
Journal of steroid biochemistry 1987;28(3):233-45.
1987: S J Brandes; John A Katzenellenbogen
Fluorinated androgens and progestins: molecular probes for androgen and progesterone receptors with potential use in positron emission tomography.
Molecular pharmacology 1987;32(3):391-403.
1987: C J Mathias; Michael J Welch; John A Katzenellenbogen; J W Brodack; Michael R Kilbourn; Kathryn E Carlson; D O Kiesewetter
Characterization of the uptake of 16 alpha-([18F]fluoro)-17 beta-estradiol in DMBA-induced mammary tumors.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1987;14(1):15-25.
1986: F G Salituro; Kathryn E Carlson; J F Elliston; Benita S Katzenellenbogen; John A Katzenellenbogen
[125I]iododesethyl tamoxifen aziridine: synthesis and covalent labeling of the estrogen receptor with an iodine-labeled affinity label.
Steroids 1986;48(5-6):287-313.
1986: Michael J Welch; Dae Yoon Chi; C J Mathias; Michael R Kilbourn; J W Brodack; John A Katzenellenbogen
Biodistribution of N-alkyl and N-fluoroalkyl derivatives of spiroperidol; radiopharmaceuticals for PET studies of dopamine receptors.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1986;13(5):523-6.
1986: Dae Yoon Chi; Michael R Kilbourn; John A Katzenellenbogen; J W Brodack; Michael J Welch
Synthesis of no-carrier-added N-([18F]fluoroalkyl)spiperone derivatives.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1986;37(12):1173-80.
1984: G C Reiner; Benita S Katzenellenbogen; R D Bindal; John A Katzenellenbogen
Biological activity and receptor binding of a strongly interacting estrogen in human breast cancer cells.
Cancer research 1984;44(6):2302-8.
1983: K D McElvany; Kathryn E Carlson; John A Katzenellenbogen; Michael J Welch
Factors affecting the target site uptake selectivity of estrogen radiopharmaceuticals: serum binding and endogenous estrogens.
Journal of steroid biochemistry 1983;18(6):635-41.
1983: John A Katzenellenbogen; K E Carlson; D F Heiman; D W Robertson; L L Wei; Benita S Katzenellenbogen
Efficient and highly selective covalent labeling of the estrogen receptor with [3H]tamoxifen aziridine.
The Journal of biological chemistry 1983;258(6):3487-95.
1982: S W Landvatter; John A Katzenellenbogen; K D McElvany; Michael J Welch
(2R*,3S*)-1-[125I]Iodo-2,3-bis(4-hydroxyphenyl)pentane ([125I]iodonorhexestrol) and (2R*,3S*)-1-[77Br]Bromo-2,3-bis(4-hydroxyphenyl)pentane ([77Br]bromonorhexestrol), two gamma-emitting estrogens that show receptor-mediated uptake by target tissues in vivo.
Journal of medicinal chemistry 1982;25(11):1307-12.
1982: S G Senderoff; K D McElvany; Kathryn E Carlson; D F Heiman; John A Katzenellenbogen; Michael J Welch
Methodology for the synthesis and specific activity determination of 16 alpha-[77Br]-bromoestradiol-17 beta and 16 alpha-[77Br]-11 beta-methoxyestradiol-17 beta, two estrogen receptor-binding radiopharmaceuticals.
The International journal of applied radiation and isotopes 1982;33(7):545-51.
1982: K D McElvany; John A Katzenellenbogen; K E Shafer; B A Siegel; S G Senderoff; Michael J Welch
16 alpha-[77Br]bromoestradiol: dosimetry and preliminary clinical studies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1982;23(5):425-30.
1982: K D McElvany; Kathryn E Carlson; Michael J Welch; S G Senderoff; John A Katzenellenbogen
In vivo comparison of 16 alpha[77Br]bromoestradiol-17 beta and 16 alpha-[125I]iodoestradiol-17 beta.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1982;23(5):420-4.
1982: John A Katzenellenbogen; K D McElvany; S G Senderoff; Kathryn E Carlson; S W Landvatter; Michael J Welch
16 alpha-[77Br]bromo-11 beta-methoxyestradiol-17 beta: a gamma-emitting estrogen imaging agent with high uptake and retention by target organs.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1982;23(5):411-9.
1981: John A Katzenellenbogen; S G Senderoff; K D McElvany; H A O'Brien; Michael J Welch
16 alpha-[77Br]bromoestradiol-17 beta: a high specific-activity, gamma-emitting tracer with uptake in rat uterus and uterus and induced mammary tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1981;22(1):42-7.
1980: D F Heiman; S G Senderoff; John A Katzenellenbogen; R J Neeley
Estrogen receptor based imaging agents. 1. Synthesis and receptor binding affinity of some aromatic and D-ring halogenated estrogens.
Journal of medicinal chemistry 1980;23(9):994-1002.
1980: R Goswami; S G Harsy; D F Heiman; John A Katzenellenbogen
Estrogen receptor based imaging agents. 2. Synthesis and receptor binding affinity of side-chain halogenated hexestrol derivatives.
Journal of medicinal chemistry 1980;23(9):1002-8.
1980: John A Katzenellenbogen; Kathryn E Carlson; D F Heiman; R Goswami
Receptor-binding radiopharmaceuticals for imaging breast tumors: estrogen-receptor interactions and selectivity of tissue uptake of halogenated estrogen analogs.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1980;21(6):550-8.